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Lancet
    April 2024
  1. GE Z, Kan J, Gao X, Raza A, et al
    Ticagrelor alone versus ticagrelor plus aspirin from month 1 to month 12 after percutaneous coronary intervention in patients with acute coronary syndromes (ULTIMATE-DAPT): a randomised, placebo-controlled, double-blind clinical trial.
    Lancet. 2024 Apr 5:S0140-6736(24)00473-2. doi: 10.1016/S0140-6736(24)00473.
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  2. PARK SJ, Ahn JM, Kang DY, Yun SC, et al
    Preventive percutaneous coronary intervention versus optimal medical therapy alone for the treatment of vulnerable atherosclerotic coronary plaques (PREVENT): a multicentre, open-label, randomised controlled trial.
    Lancet. 2024 Apr 4:S0140-6736(24)00413-6. doi: 10.1016/S0140-6736(24)00413.
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  3. Global burden of 288 causes of death and life expectancy decomposition in 204 countries and territories and 811 subnational locations, 1990-2021: a systematic analysis for the Global Burden of Disease Study 2021.
    Lancet. 2024 Apr 3:S0140-6736(24)00367-2. doi: 10.1016/S0140-6736(24)00367.
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    March 2024
  4. VAHL TP, Thourani VH, Makkar RR, Hamid N, et al
    Transcatheter aortic valve implantation in patients with high-risk symptomatic native aortic regurgitation (ALIGN-AR): a prospective, multicentre, single-arm study.
    Lancet. 2024 Mar 26:S0140-6736(23)02806-4. doi: 10.1016/S0140-6736(23)02806.
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  5. MELLO A, Stehr D, Bujarski K, Duchaine B, et al
    Visualising facial distortions in prosopometamorphopsia.
    Lancet. 2024;403:1176.
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  6. Global fertility in 204 countries and territories, 1950-2021, with forecasts to 2100: a comprehensive demographic analysis for the Global Burden of Disease Study 2021.
    Lancet. 2024 Mar 19:S0140-6736(24)00550-6. doi: 10.1016/S0140-6736(24)00550.
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  7. CHEN WG, Edwards E, Iyengar S, Finkelstein R, et al
    Music and medicine: quickening the tempo of progress.
    Lancet. 2024 Mar 18:S0140-6736(24)00477-X. doi: 10.1016/S0140-6736(24)00477.
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  8. Global age-sex-specific mortality, life expectancy, and population estimates in 204 countries and territories and 811 subnational locations, 1950-2021, and the impact of the COVID-19 pandemic: a comprehensive demographic analysis for the Global Burden
    Lancet. 2024 Mar 8:S0140-6736(24)00476-8. doi: 10.1016/S0140-6736(24)00476.
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    February 2024
  9. CONSOLI A, Gory B
    Long-term results of mechanical thrombectomy for large ischaemic stroke.
    Lancet. 2024 Feb 8:S0140-6736(24)00158-2. doi: 10.1016/S0140-6736(24)00158.
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  10. SARRAJ A, Abraham MG, Hassan AE, Blackburn S, et al
    Endovascular thrombectomy plus medical care versus medical care alone for large ischaemic stroke: 1-year outcomes of the SELECT2 trial.
    Lancet. 2024 Feb 8:S0140-6736(24)00050-3. doi: 10.1016/S0140-6736(24)00050.
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    January 2024
  11. BEN-SHLOMO Y, Darweesh S, Llibre-Guerra J, Marras C, et al
    The epidemiology of Parkinson's disease.
    Lancet. 2024;403:283-292.
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    November 2023
  12. FROST R, Avgerinou C, Kalwarowsky S, Mahmood F, et al
    Enabling health and maintaining independence for older people at home (HomeHealth trial): a multicentre randomised controlled trial.
    Lancet. 2023;402 Suppl 1:S42.
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  13. BARRADO-MARTIN Y, Frost R, Catchpole J, Rookes T, et al
    Goal setting as part of a holistic intervention to promote independence in older people with mild frailty: a process evaluation alongside a randomised controlled trial.
    Lancet. 2023;402 Suppl 1:S1.
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  14. LIU L, Li X, Marshall IJ, Bhalla A, et al
    Trajectories of depressive symptoms 10 years after stroke and associated risk factors: a prospective cohort study.
    Lancet. 2023;402 Suppl 1:S64.
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    October 2023
  15. MESSERLI FH, Bangalore S, Mandrola JM
    beta blockers switched to first-line therapy in hypertension.
    Lancet. 2023 Oct 13:S0140-6736(23)01733-6. doi: 10.1016/S0140-6736(23)01733.
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  16. DIPPEL DWJ, Roozenbeek B
    Thrombectomy for acute ischaemic stroke without advanced imaging.
    Lancet. 2023 Oct 10:S0140-6736(23)02229-8. doi: 10.1016/S0140-6736(23)02229.
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  17. BENDSZUS M, Fiehler J, Subtil F, Bonekamp S, et al
    Endovascular thrombectomy for acute ischaemic stroke with established large infarct: multicentre, open-label, randomised trial.
    Lancet. 2023 Oct 10:S0140-6736(23)02032-9. doi: 10.1016/S0140-6736(23)02032.
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    August 2023
  18. MAKKAR RR, Kapadia S, Chakravarty T, Cubeddu RJ, et al
    Outcomes of repeat transcatheter aortic valve replacement with balloon-expandable valves: a registry study.
    Lancet. 2023 Aug 31:S0140-6736(23)01636-7. doi: 10.1016/S0140-6736(23)01636.
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  19. MAJOIE CB, Cavalcante F, Gralla J, Yang P, et al
    Value of intravenous thrombolysis in endovascular treatment for large-vessel anterior circulation stroke: individual participant data meta-analysis of six randomised trials.
    Lancet. 2023 Aug 25:S0140-6736(23)01142-X. doi: 10.1016/S0140-6736(23)01142.
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  20. HANKEY GJ
    Does thrombolysis add value to thrombectomy for acute ischaemic stroke?
    Lancet. 2023 Aug 25:S0140-6736(23)01202-3. doi: 10.1016/S0140-6736(23)01202.
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  21. WILKOFF BL, Filippatos G, Leclercq C, Gold MR, et al
    Adaptive versus conventional cardiac resynchronisation therapy in patients with heart failure (AdaptResponse): a global, prospective, randomised controlled trial.
    Lancet. 2023 Aug 24:S0140-6736(23)00912-1. doi: 10.1016/S0140-6736(23)00912.
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    July 2023
  22. STRANDELL A, Hellgren M
    Time to stop routine prescription of low-molecular-weight heparin to women with recurrent pregnancy loss and inherited thrombophilia.
    Lancet. 2023;402:6-7.
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    June 2023
  23. HUANG C, Huang L, Wang Y, Li X, et al
    6-month consequences of COVID-19 in patients discharged from hospital: a cohort study.
    Lancet. 2023 Jun 12:S0140-6736(23)00810-3. doi: 10.1016/S0140-6736(23)00810.
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    May 2023
  24. MA L, Hu X, Song L, Chen X, et al
    The third Intensive Care Bundle with Blood Pressure Reduction in Acute Cerebral Haemorrhage Trial (INTERACT3): an international, stepped wedge cluster randomised controlled trial.
    Lancet. 2023 May 24:S0140-6736(23)00806-1. doi: 10.1016/S0140-6736(23)00806.
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    April 2023
  25. WARDLAW JM
    Even more benefit with endovascular treatment for patients with acute ischaemic stroke: MR CLEAN-LATE.
    Lancet. 2023;401:1317-1319.
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  26. HAWKEY C
    Helicobacter pylori eradication and aspirin: a puzzle yet to be solved - Author's reply.
    Lancet. 2023;401:1266.
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  27. GATTA L, Zullo A, Vaira D
    Helicobacter pylori eradication and aspirin: a puzzle yet to be solved.
    Lancet. 2023;401:1265-1266.
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  28. LI Y, Liang Z, Stone GW, Han Y, et al
    BRIGHT-4 trial: bivalirudin strikes back - Authors' reply.
    Lancet. 2023;401:1158.
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  29. PIRIOU PG, Manigold T, Letocart V, Guerin P, et al
    BRIGHT-4 trial: bivalirudin strikes back.
    Lancet. 2023;401:1157-1158.
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    March 2023
  30. OLTHUIS SGH, Pirson FAV, Pinckaers FME, Hinsenveld WH, et al
    Endovascular treatment versus no endovascular treatment after 6-24 h in patients with ischaemic stroke and collateral flow on CT angiography (MR CLEAN-LATE) in the Netherlands: a multicentre, open-label, blinded-endpoint, randomised, controlled, phase
    Lancet. 2023 Mar 29:S0140-6736(23)00575-5. doi: 10.1016/S0140-6736(23)00575.
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  31. KLOK FA, Siegerink B
    Ordinal outcomes add value to clinical trials.
    Lancet. 2023;401:995.
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  32. HE J, Ouyang N, Guo X, Sun G, et al
    Effectiveness of a non-physician community health-care provider-led intensive blood pressure intervention versus usual care on cardiovascular disease (CRHCP): an open-label, blinded-endpoint, cluster-randomised trial.
    Lancet. 2023 Mar 2:S0140-6736(22)02603-4. doi: 10.1016/S0140-6736(22)02603.
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    February 2023
  33. WANG Y, Li S, Pan Y, Li H, et al
    Tenecteplase versus alteplase in acute ischaemic cerebrovascular events (TRACE-2): a phase 3, multicentre, open-label, randomised controlled, non-inferiority trial.
    Lancet. 2023 Feb 8:S0140-6736(22)02600-9. doi: 10.1016/S0140-6736(22)02600.
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  34. MENON BK, Singh N, Sylaja PN
    Tenecteplase use in patients with acute ischaemic stroke.
    Lancet. 2023 Feb 8:S0140-6736(22)02633-2. doi: 10.1016/S0140-6736(22)02633.
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    January 2023
  35. WERRING DJ, Banerjee G
    Convexity subarachnoid haemorrhage.
    Lancet. 2023;401:193-194.
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    November 2022

  36. Personalised cooler dialysate for patients receiving maintenance haemodialysis (MyTEMP): a pragmatic, cluster-randomised trial.
    Lancet. 2022;400:1693-1703.
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  37. YANG P, Song L, Zhang Y, Zhang X, et al
    Intensive blood pressure control after endovascular thrombectomy for acute ischaemic stroke (ENCHANTED2/MT): a multicentre, open-label, blinded-endpoint, randomised controlled trial.
    Lancet. 2022;400:1585-1596.
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  38. MISTRY EA, Nguyen TN
    Blood pressure goals after mechanical thrombectomy: a moving target.
    Lancet. 2022;400:1558-1559.
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    October 2022
  39. BISTERVELS IM, Buchmuller A, Wiegers HMG, Ni Ainle F, et al
    Intermediate-dose versus low-dose low-molecular-weight heparin in pregnant and post-partum women with a history of venous thromboembolism (Highlow study): an open-label, multicentre, randomised, controlled trial.
    Lancet. 2022 Oct 28. pii: S0140-6736(22)02128.
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  40. MACKENZIE IS, Hawkey CJ, Ford I, Greenlaw N, et al
    Allopurinol versus usual care in UK patients with ischaemic heart disease (ALL-HEART): a multicentre, prospective, randomised, open-label, blinded-endpoint trial.
    Lancet. 2022;400:1195-1205.
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    September 2022
  41. SHOAMANESH A, Mundl H, Smith EE, Masjuan J, et al
    Factor XIa inhibition with asundexian after acute non-cardioembolic ischaemic stroke (PACIFIC-Stroke): an international, randomised, double-blind, placebo-controlled, phase 2b trial.
    Lancet. 2022 Sep 2. pii: S0140-6736(22)01588.
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  42. DIENER HC, Rothwell PM
    Antithrombotic drugs in secondary stroke prevention: still some way to go.
    Lancet. 2022 Sep 2. pii: S0140-6736(22)01703.
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    July 2022
  43. MACSWEENEY S, Subramanian G, Podlasek A, Auer D, et al
    Urgent need to update NICE guidelines on imaging for transient ischaemic attack.
    Lancet. 2022 Jul 12. pii: S0140-6736(22)01281.
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  44. KHATRI P
    Intravenous thrombolysis before thrombectomy for acute ischaemic stroke.
    Lancet. 2022;400:76-78.
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  45. MITCHELL PJ, Yan B, Churilov L, Dowling RJ, et al
    Endovascular thrombectomy versus standard bridging thrombolytic with endovascular thrombectomy within 4.5 h of stroke onset: an open-label, blinded-endpoint, randomised non-inferiority trial.
    Lancet. 2022;400:116-125.
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  46. FISCHER U, Kaesmacher J, Strbian D, Eker O, et al
    Thrombectomy alone versus intravenous alteplase plus thrombectomy in patients with stroke: an open-label, blinded-outcome, randomised non-inferiority trial.
    Lancet. 2022;400:104-115.
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    June 2022
  47. SANDSET EC, Tsvigoulis G
    Tenecteplase for acute ischaemic stroke.
    Lancet. 2022 Jun 28. pii: S0140-6736(22)01107.
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  48. MENON BK, Buck BH, Singh N, Deschaintre Y, et al
    Intravenous tenecteplase compared with alteplase for acute ischaemic stroke in Canada (AcT): a pragmatic, multicentre, open-label, registry-linked, randomised, controlled, non-inferiority trial.
    Lancet. 2022 Jun 28. pii: S0140-6736(22)01054.
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    May 2022
  49. DELGADO-LISTA J, Alcala-Diaz JF, Torres-Pena JD, Quintana-Navarro GM, et al
    Long-term secondary prevention of cardiovascular disease with a Mediterranean diet and a low-fat diet (CORDIOPREV): a randomised controlled trial.
    Lancet. 2022 May 4. pii: S0140-6736(22)00122.
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    April 2022
  50. PICCINI JP, Caso V, Connolly SJ, Fox KAA, et al
    Safety of the oral factor XIa inhibitor asundexian compared with apixaban in patients with atrial fibrillation (PACIFIC-AF): a multicentre, randomised, double-blind, double-dummy, dose-finding phase 2 study.
    Lancet. 2022;399:1383-1390.
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    March 2022

  51. Progress in health among regions of Ethiopia, 1990-2019: a subnational country analysis for the Global Burden of Disease Study 2019.
    Lancet. 2022 Mar 11. pii: S0140-6736(21)02868.
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    February 2022
  52. ALMEKHLAFI MA, Coutts SB
    Anti-thrombotics cause harm in the setting of stroke thrombectomy.
    Lancet. 2022 Feb 28. pii: S0140-6736(22)00335.
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  53. VAN DER STEEN W, van de Graaf RA, Chalos V, Lingsma HF, et al
    Safety and efficacy of aspirin, unfractionated heparin, both, or neither during endovascular stroke treatment (MR CLEAN-MED): an open-label, multicentre, randomised controlled trial.
    Lancet. 2022 Feb 28. pii: S0140-6736(22)00014.
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    January 2022
  54. SHAH SJ, Borlaug BA, Chung ES, Cutlip DE, et al
    Atrial shunt device for heart failure with preserved and mildly reduced ejection fraction (REDUCE LAP-HF II): a randomised, multicentre, blinded, sham-controlled trial.
    Lancet. 2022 Jan 31. pii: S0140-6736(22)00016.
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    November 2021
  55. JOVIN TG, Nogueira RG, Lansberg MG, Demchuk AM, et al
    Thrombectomy for anterior circulation stroke beyond 6 h from time last known well (AURORA): a systematic review and individual patient data meta-analysis.
    Lancet. 2021 Nov 11. pii: S0140-6736(21)01341.
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  56. DIPPEL D, Roozenbeek B
    Late thrombectomy for ischaemic stroke.
    Lancet. 2021 Nov 11. pii: S0140-6736(21)02097.
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    October 2021
  57. KIM CJ, Park MW, Kim MC, Choo EH, et al
    Unguided de-escalation from ticagrelor to clopidogrel in stabilised patients with acute myocardial infarction undergoing percutaneous coronary intervention (TALOS-AMI): an investigator-initiated, open-label, multicentre, non-inferiority, randomised tr
    Lancet. 2021;398:1305-1316.
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    September 2021
  58. TULAMO R, Venermo M
    Intervention for asymptomatic carotid artery stenosis.
    Lancet. 2021;398:1025-1027.
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    August 2021
  59. SVENNBERG E, Friberg L, Frykman V, Al-Khalili F, et al
    Clinical outcomes in systematic screening for atrial fibrillation (STROKESTOP): a multicentre, parallel group, unmasked, randomised controlled trial.
    Lancet. 2021 Aug 27. pii: S0140-6736(21)01637.
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  60. HALLIDAY A, Bulbulia R, Bonati LH, Chester J, et al
    Second asymptomatic carotid surgery trial (ACST-2): a randomised comparison of carotid artery stenting versus carotid endarterectomy.
    Lancet. 2021 Aug 27. pii: S0140-6736(21)01910.
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  61. JOSEPH P, Roshandel G, Gao P, Pais P, et al
    Fixed-dose combination therapies with and without aspirin for primary prevention of cardiovascular disease: an individual participant data meta-analysis.
    Lancet. 2021 Aug 27. pii: S0140-6736(21)01827.
    >> Share

  62. FREEDMAN B, Lowres N
    High-intensity atrial fibrillation screening to prevent stroke.
    Lancet. 2021 Aug 27. pii: S0140-6736(21)01785.
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  63. LOWRES N, Freedman B
    Population screening for atrial fibrillation to prevent stroke.
    Lancet. 2021 Aug 27. pii: S0140-6736(21)01750.
    >> Share

  64. SVENDSEN JH, Diederichsen SZ, Hojberg S, Krieger DW, et al
    Implantable loop recorder detection of atrial fibrillation to prevent stroke (The LOOP Study): a randomised controlled trial.
    Lancet. 2021 Aug 27. pii: S0140-6736(21)01698.
    >> Share


  65. Age-stratified and blood-pressure-stratified effects of blood-pressure-lowering pharmacotherapy for the prevention of cardiovascular disease and death: an individual participant-level data meta-analysis.
    Lancet. 2021 Aug 26. pii: S0140-6736(21)01921.
    >> Share

  66. BURKART KG, Brauer M, Aravkin AY, Godwin WW, et al
    Estimating the cause-specific relative risks of non-optimal temperature on daily mortality: a two-part modelling approach applied to the Global Burden of Disease Study.
    Lancet. 2021;398:685-697.
    >> Share

    July 2021
  67. KATSOULARIS I, Fonseca-Rodriguez O, Farrington P, Lindmark K, et al
    Risk of acute myocardial infarction and ischaemic stroke following COVID-19 in Sweden: a self-controlled case series and matched cohort study.
    Lancet. 2021 Jul 29. pii: S0140-6736(21)00896.
    >> Share

  68. MAFHAM M, Baigent C
    What is the association of COVID-19 with heart attacks and strokes?
    Lancet. 2021 Jul 29. pii: S0140-6736(21)01071.
    >> Share

    May 2021
  69. KOO BK, Kang J, Park KW, Rhee TM, et al
    Aspirin versus clopidogrel for chronic maintenance monotherapy after percutaneous coronary intervention (HOST-EXAM): an investigator-initiated, prospective, randomised, open-label, multicentre trial.
    Lancet. 2021 May 14. pii: S0140-6736(21)01063.
    >> Share


  70. Pharmacological blood pressure lowering for primary and secondary prevention of cardiovascular disease across different levels of blood pressure: an individual participant-level data meta-analysis.
    Lancet. 2021;397:1625-1636.
    >> Share

    April 2021
  71. VAN DER MEIJ A, Wermer MJH
    Vagus nerve stimulation: a potential new treatment for ischaemic stroke.
    Lancet. 2021;397:1520-1521.
    >> Share

  72. DAWSON J, Liu CY, Francisco GE, Cramer SC, et al
    Vagus nerve stimulation paired with rehabilitation for upper limb motor function after ischaemic stroke (VNS-REHAB): a randomised, blinded, pivotal, device trial.
    Lancet. 2021;397:1545-1553.
    >> Share

  73. GALLI M, Benenati S, Capodanno D, Franchi F, et al
    Guided versus standard antiplatelet therapy in patients undergoing percutaneous coronary intervention: a systematic review and meta-analysis.
    Lancet. 2021;397:1470-1483.
    >> Share

  74. BAYAS A, Menacher M, Christ M, Behrens L, et al
    Bilateral superior ophthalmic vein thrombosis, ischaemic stroke, and immune thrombocytopenia after ChAdOx1 nCoV-19 vaccination.
    Lancet. 2021 Apr 14. pii: S0140-6736(21)00872.
    >> Share

    March 2021
  75. TUNA MA, Rothwell PM
    Diagnosis of non-consensus transient ischaemic attacks with focal, negative, and non-progressive symptoms: population-based validation by investigation and prognosis.
    Lancet. 2021;397:902-912.
    >> Share

    February 2021
  76. BENJAMIN LA, Phiri T, Simister R, Solomon T, et al
    Recognising HIV infection in systems of care for stroke.
    Lancet. 2021;397:794.
    >> Share

  77. PANDIAN JD, Kalkonde Y, Sebastian IA, Bosch J, et al
    Recognising HIV infection in systems of care for stroke - Authors' reply.
    Lancet. 2021;397:794-795.
    >> Share

  78. LANGLEY RE, Gilbert DC, Duong T, Clarke NW, et al
    Transdermal oestradiol for androgen suppression in prostate cancer: long-term cardiovascular outcomes from the randomised Prostate Adenocarcinoma Transcutaneous Hormone (PATCH) trial programme.
    Lancet. 2021;397:581-591.
    >> Share

    December 2020
  79. SCOTT IU, Campochiaro PA, Newman NJ, Biousse V, et al
    Retinal vascular occlusions.
    Lancet. 2020;396:1927-1940.
    >> Share

    November 2020
  80. GENCER B, Marston NA, Im K, Cannon CP, et al
    Efficacy and safety of lowering LDL cholesterol in older patients: a systematic review and meta-analysis of randomised controlled trials.
    Lancet. 2020;396:1637-1643.
    >> Share

  81. THOMALLA G, Boutitie F, Ma H, Koga M, et al
    Intravenous alteplase for stroke with unknown time of onset guided by advanced imaging: systematic review and meta-analysis of individual patient data.
    Lancet. 2020 Nov 6. pii: S0140-6736(20)32163.
    >> Share

    October 2020
  82. PANDIAN JD, Kalkonde Y, Sebastian IA, Felix C, et al
    Stroke systems of care in low-income and middle-income countries: challenges and opportunities.
    Lancet. 2020;396:1443-1451.
    >> Share

  83. LANGHORNE P, Audebert HJ, Cadilhac DA, Kim J, et al
    Stroke systems of care in high-income countries: what is optimal?
    Lancet. 2020;396:1433-1442.
    >> Share

    September 2020

  84. NCD Countdown 2030: pathways to achieving Sustainable Development Goal target 3.4.
    Lancet. 2020;396:918-934.
    >> Share

  85. MAKKAR RR, Cheng W, Waksman R, Satler LF, et al
    Self-expanding intra-annular versus commercially available transcatheter heart valves in high and extreme risk patients with severe aortic stenosis (PORTICO IDE): a randomised, controlled, non-inferiority trial.
    Lancet. 2020;396:669-683.
    >> Share


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