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Articles published in
Proc Natl Acad Sci U S A
    December 2025
  1. TRAN PM, Anaya-Sanchez A, Ji DX, Schwarz MCR, et al
    Cell envelope maintenance by PhoP is essential for Mycobacterium tuberculosis methylglyoxal resistance.
    Proc Natl Acad Sci U S A. 2025;122:e2523024122.
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    October 2025
  2. DANCHUK SN, Duffy SC, Sullivan J, Beenish Rufai S, et al
    Virulence hierarchies within the Mycobacterium tuberculosis complex.
    Proc Natl Acad Sci U S A. 2025;122:e2507104122.
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    September 2025
  3. FOUNTAIN AJ, Bohning J, McLaughlin SH, Morgan TE, et al
    Structural and functional analysis of the Mycobacterium tuberculosis MmpS5L5 efflux pump presages increased bedaquiline resistance.
    Proc Natl Acad Sci U S A. 2025;122:e2516660122.
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  4. LE MOUELLIC W, Levillain F, Wu TD, Caouaille M, et al
    Inorganic sulfate is critical for Mycobacterium tuberculosis lung tissue colonization and redox balance.
    Proc Natl Acad Sci U S A. 2025;122:e2503966122.
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  5. KOLESKE B, Rajagopalan S, Schill C, Lun S, et al
    Loss of the ESX-5 secretion locus in Mycobacterium tuberculosis reshapes the mycomembrane and enhances ESX-1 substrate secretion.
    Proc Natl Acad Sci U S A. 2025;122:e2509997122.
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  6. WANG ER, Cho K, Harrison GA, Smelyansky SR, et al
    Metabolic rewiring of isoniazid sensitivity in Mycobacterium tuberculosis.
    Proc Natl Acad Sci U S A. 2025;122:e2421336122.
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    July 2025
  7. CHAUHAN K, Datta D, Kapoor Y, Passricha N, et al
    A Mycobacterium tuberculosis secreted virulence factor Rv1435c/hsr1 disrupts host snRNP biogenesis.
    Proc Natl Acad Sci U S A. 2025;122:e2423349122.
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    May 2025
  8. SANTAMARIA C, Biegas KJ, Lim PN, Cabral J, et al
    Trehalose dimycolate inhibits phagosome maturation and promotes intracellular M. tuberculosis growth via noncanonical SNARE interactions.
    Proc Natl Acad Sci U S A. 2025;122:e2423292122.
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    April 2025
  9. FOUNTAIN AJ, Waller NJE, Cheung CY, Jowsey W, et al
    Verapamil and its metabolite norverapamil inhibit the Mycobacterium tuberculosis MmpS5L5 efflux pump to increase bedaquiline activity.
    Proc Natl Acad Sci U S A. 2025;122:e2426827122.
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  10. Correction for Quach et al., Deep learning-driven bacterial cytological profiling to determine antimicrobial mechanisms in Mycobacterium tuberculosis.
    Proc Natl Acad Sci U S A. 2025;122:e2504475122.
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    March 2025
  11. YANG Z, Zhang L, Ottavi S, Geri JB, et al
    ACOD1-mediated lysosomal membrane permeabilization contributes to Mycobacterium tuberculosis-induced macrophage death.
    Proc Natl Acad Sci U S A. 2025;122:e2425309122.
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  12. MISHRA S, Singh PR, Hu X, Lopez-Quezada L, et al
    Candidate transmission survival genome of Mycobacterium tuberculosis.
    Proc Natl Acad Sci U S A. 2025;122:e2425981122.
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  13. SAHA S, Roy S, Hazra A, Das D, et al
    S-nitrosylation-triggered secretion of mycobacterial PknG leads to phosphorylation of SODD to prevent apoptosis of infected macrophages.
    Proc Natl Acad Sci U S A. 2025;122:e2404106122.
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  14. OLUOCH PO, Koh EI, Proulx MK, Reames CJ, et al
    Chemical genetic interactions elucidate pathways controlling tuberculosis antibiotic efficacy during infection.
    Proc Natl Acad Sci U S A. 2025;122:e2417525122.
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    February 2025
  15. LU Z, Zhang Y, Zhong Y, Qiang L, et al
    A bacterial effector manipulates host lysosomal protease activity-dependent plasticity in cell death modalities to facilitate infection.
    Proc Natl Acad Sci U S A. 2025;122:e2406715122.
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  16. QUACH D, Sharp M, Ahmed S, Ames L, et al
    Deep learning-driven bacterial cytological profiling to determine antimicrobial mechanisms in Mycobacterium tuberculosis.
    Proc Natl Acad Sci U S A. 2025;122:e2419813122.
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    January 2025
  17. PRIYA M, Gupta SK, Koundal A, Kapoor S, et al
    Itaconate mechanism of action and dissimilation in Mycobacterium tuberculosis.
    Proc Natl Acad Sci U S A. 2025;122:e2423114122.
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    December 2024
  18. KAHNE SC, Yoo JH, Chen J, Nakedi K, et al
    Identification of a depupylation regulator for an essential enzyme in Mycobacterium tuberculosis.
    Proc Natl Acad Sci U S A. 2024;121:e2407239121.
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    October 2024
  19. LI D, Zhang X, Yao Y, Sun X, et al
    Structure and function of Mycobacterium tuberculosis EfpA as a lipid transporter and its inhibition by BRD-8000.3.
    Proc Natl Acad Sci U S A. 2024;121:e2412653121.
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  20. ABHIMANYU, Longlax SC, Nishiguchi T, Ladki M, et al
    TCA metabolism regulates DNA hypermethylation in LPS and Mycobacterium tuberculosis-induced immune tolerance.
    Proc Natl Acad Sci U S A. 2024;121:e2404841121.
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    July 2024

  21. Correction for Rengarajan et al., Mycobacterium tuberculosis Rv2224c modulates innate immune responses.
    Proc Natl Acad Sci U S A. 2024;121:e2410437121.
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    June 2024
  22. OGUNLADE B, Tadesse LF, Li H, Vu N, et al
    Rapid, antibiotic incubation-free determination of tuberculosis drug resistance using machine learning and Raman spectroscopy.
    Proc Natl Acad Sci U S A. 2024;121:e2315670121.
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  23. COHEN SB, Urdahl KB
    Weaponizing the bystander T cell army to fight tuberculosis.
    Proc Natl Acad Sci U S A. 2024;121:e2407559121.
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    May 2024
  24. PATERSON RL, La Manna MP, Arena De Souza V, Walker A, et al
    An HLA-E-targeted TCR bispecific molecule redirects T cell immunity against Mycobacterium tuberculosis.
    Proc Natl Acad Sci U S A. 2024;121:e2318003121.
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    April 2024
  25. DATTA M, Via LE, Dartois V, Weiner DM, et al
    Normalizing granuloma vasculature and matrix improves drug delivery and reduces bacterial burden in tuberculosis-infected rabbits.
    Proc Natl Acad Sci U S A. 2024;121:e2321336121.
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  26. FORTUNE SM
    The Titanic question in TB control: Should we worry about the bummock?
    Proc Natl Acad Sci U S A. 2024;121:e2403321121.
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    March 2024
  27. PATTERSON B, Dinkele R, Gessner S, Koch A, et al
    Aerosolization of viable Mycobacterium tuberculosis bacilli by tuberculosis clinic attendees independent of sputum-Xpert Ultra status.
    Proc Natl Acad Sci U S A. 2024;121:e2314813121.
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    January 2024
  28. CHUGH S, Tiwari P, Suri C, Gupta SK, et al
    Polyphosphate kinase-1 regulates bacterial and host metabolic pathways involved in pathogenesis of Mycobacterium tuberculosis.
    Proc Natl Acad Sci U S A. 2024;121:e2309664121.
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    November 2023
  29. HORTON KC, Richards AS, Emery JC, Esmail H, et al
    Reevaluating progression and pathways following Mycobacterium tuberculosis infection within the spectrum of tuberculosis.
    Proc Natl Acad Sci U S A. 2023;120:e2221186120.
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    August 2023
  30. LIANG J, Liu F, Xu P, Shangguan W, et al
    Molecular recognition of trehalose and trehalose analogues by Mycobacterium tuberculosis LpqY-SugABC.
    Proc Natl Acad Sci U S A. 2023;120:e2307625120.
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    July 2023
  31. VARGAS R JR, Luna MJ, Freschi L, Marin M, et al
    Phase variation as a major mechanism of adaptation in Mycobacterium tuberculosis complex.
    Proc Natl Acad Sci U S A. 2023;120:e2301394120.
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    June 2023
  32. GONG Y, Wei C, Wang J, Mu N, et al
    Structure of the priming arabinosyltransferase AftA required for AG biosynthesis of Mycobacterium tuberculosis.
    Proc Natl Acad Sci U S A. 2023;120:e2302858120.
    >> Share


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