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Articles published in
J Clin Invest
    September 2024
  1. XING W, Feng H, Jiang B, Gao B, et al
    Itm2a expression marks periosteal skeletal stem cells that contribute to bone fracture healing.
    J Clin Invest. 2024;134:e176528.
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    August 2024
  2. BORDENAVE J, Gajda D, Michonneau D, Vallet N, et al
    Deciphering bone marrow engraftment after allogeneic stem cell transplantation in humans using single cell analyses.
    J Clin Invest. 2024 Aug 29:e180331. doi: 10.1172/JCI180331.
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  3. WALKER NM, Ibuki Y, McLinden AP, Misumi K, et al
    MNK-driven eIF4E phosphorylation regulates the fibrogenic transformation of mesenchymal cells and chronic lung allograft dysfunction.
    J Clin Invest. 2024;134:e168393.
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  4. SCHLEICHER WE, Hoag B, De Dominici M, DeGregori J, et al
    CHIP: a clonal odyssey of the bone marrow niche.
    J Clin Invest. 2024;134:e180068.
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    July 2024
  5. WU K, Zhang Y, Yin-DeClue H, Sun K, et al
    A correctable immune niche for epithelial stem-cell reprogramming and post-viral lung diseases.
    J Clin Invest. 2024 Jul 25:e183092. doi: 10.1172/JCI183092.
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    June 2024
  6. MAROM R, Song IW, Busse EC, Washington ME, et al
    The IFITM5 mutation in osteogenesis imperfecta type V is associated with an ERK/SOX9-dependent osteoprogenitor differentiation defect.
    J Clin Invest. 2024;134:e170369.
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    May 2024
  7. SELGRADE DF, Fullenkamp DE, Chychula IA, Li B, et al
    Susceptibility to innate immune activation in genetically mediated myocarditis.
    J Clin Invest. 2024;134:e180254.
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  8. SAUL D, Doolittle ML, Rowsey JL, Froemming MN, et al
    Osteochondroprogenitor cells and neutrophils expressing p21 and senescence markers modulate fracture repair.
    J Clin Invest. 2024;134:e179834.
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  9. LENARDIC A, Domenig SA, Zvick J, Bundschuh N, et al
    Generation of allogenic and xenogeneic functional muscle stem cells for intramuscular transplantation.
    J Clin Invest. 2024 May 7:e166998. doi: 10.1172/JCI166998.
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    April 2024
  10. MOE A, Rayasam A, Sauber G, Shah RK, et al
    Type 2 cannabinoid receptor expression on microglial cells regulates neuroinflammation during graft versus host disease.
    J Clin Invest. 2024 Apr 25:e175205. doi: 10.1172/JCI175205.
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  11. SONG X, Tiek D, Miki S, Huang T, et al
    RNA splicing analysis deciphers developmental hierarchies and reveals therapeutic targets in adult glioma.
    J Clin Invest. 2024;134:e173789.
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  12. KEAN LS, Blazar BR
    Major breakthroughs in hematopoietic stem cell transplantation and future challenges in clinical implementation.
    J Clin Invest. 2024;134:e179944.
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  13. NORTH D, Chakraverty R
    The road to refractory graft-versus-host disease is paved with good intentions.
    J Clin Invest. 2024;134:e177728.
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  14. ZHANG P, Fleming P, Andoniou CE, Waltner OG, et al
    IL-6-mediated endothelial injury impairs antiviral humoral immunity after bone marrow transplantation.
    J Clin Invest. 2024;134:e174184.
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    March 2024
  15. MA H, Lu C, Ziegler J, Liu A, et al
    Absence of Stat1 in donor CD4+ T cells promotes the expansion of Tregs and reduces graft-versus-host disease in mice.
    J Clin Invest. 2024;134:e180350.
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  16. ORAVECZ-WILSON K, Lauder E, Taylor A, Maneix L, et al
    Autophagy differentially regulates tissue tolerance of distinct target organs in graft-versus-host disease models.
    J Clin Invest. 2024;134:e167369.
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    January 2024
  17. LUO M, Bao L, Xue Y, Zhu M, et al
    ZMYND8 protects breast cancer stem cells against oxidative stress and ferroptosis through activation of NRF2.
    J Clin Invest. 2024;134:e171166.
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  18. SUN YL, Hennessey EE, Heins H, Yang P, et al
    Human pluripotent stem cell modeling of alveolar type 2 cell dysfunction caused by ABCA3 mutations.
    J Clin Invest. 2024;134:e164274.
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  19. HAIDER N, Kahn CR
    Interactions among insulin resistance, epigenetics, and donor sex in gene expression regulation of iPSC-derived myoblasts.
    J Clin Invest. 2024;134:e172333.
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  20. SIEW JJ, Chen HM, Chiu FL, Lee CW, et al
    Galectin-3 aggravates microglial activation and tau transmission in tauopathy.
    J Clin Invest. 2024;134:e165523.
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    December 2023
  21. MASON EC, Menon S, Schneider BR, Gaskill CF, et al
    Activation of mTOR signaling in adult lung microvascular progenitor cells accelerates lung aging.
    J Clin Invest. 2023;133:e171430.
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    November 2023
  22. AVNI B, Neiman D, Shaked ED, Gal-Rosenberg O, et al
    Chronic graft versus host disease detected by tissue-specific cell-free DNA methylation biomarkers.
    J Clin Invest. 2023 Nov 16:e163541. doi: 10.1172/JCI163541.
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  23. LI M, Nishimura T, Takeuchi Y, Hongu T, et al
    FXYD3 functionally demarcates an ancestral breast cancer stem cell subpopulation with features of drug-tolerant persisters.
    J Clin Invest. 2023;133:e166666.
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  24. VAZQUEZ-ARMENDARIZ AI, Tata PR
    Recent advances in lung organoid development and applications in disease modeling.
    J Clin Invest. 2023;133:e170500.
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  25. LOVEWELL RR, Hong J, Kundu S, Fielder CM, et al
    LAIR-1 agonism as a therapy for acute myeloid leukemia.
    J Clin Invest. 2023;133:e169519.
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    October 2023
  26. KABRA M, Shahi PK, Wang Y, Sinha D, et al
    Nonviral base editing of KCNJ13 mutation preserves vision in a model of inherited retinal channelopathy.
    J Clin Invest. 2023;133:e171356.
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    August 2023
  27. YU C, Sheng Y, Yu F, Ni H, et al
    Foxm1 haploinsufficiency drives clonal hematopoiesis and promotes a stress-related transition to hematologic malignancy in mice.
    J Clin Invest. 2023;133:e163911.
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  28. LI Q, Wang X, Song Q, Yang S, et al
    Donor T cell STAT3 deficiency enables tissue PD-L1-dependent prevention of graft-versus-host disease while preserving graft-versus-leukemia activity.
    J Clin Invest. 2023;133:e165723.
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  29. BRANDSTADTER JD, Outen R, Maillard I
    Having it both ways: how STAT3 deficiency blocks graft-versus-host disease while preserving graft-versus-leukemia activity.
    J Clin Invest. 2023;133:e172251.
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  30. LOGAN BR, Fu D, Howard A, Fei M, et al
    Validated graft-specific biomarkers identify patients at risk for chronic graft-versus-host disease and death.
    J Clin Invest. 2023;133:e168575.
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    July 2023
  31. SHAH AH, Rivas SR, Doucet-O'Hare TT, Govindarajan V, et al
    Human endogenous retrovirus K contributes to a stem cell niche in glioblastoma.
    J Clin Invest. 2023;133:e167929.
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    June 2023
  32. LIN Y, Gu Q, Lu S, Pan Z, et al
    Ruxolitinib improves hematopoietic regeneration by restoring mesenchymal stromal cell function in acute graft-versus-host disease.
    J Clin Invest. 2023 Jun 20:e162201. doi: 10.1172/JCI162201.
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  33. PASUPULETI SK, Ramdas B, Burns SS, Palam LR, et al
    Obesity-induced inflammation exacerbates clonal hematopoiesis.
    J Clin Invest. 2023;133:e163968.
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    May 2023
  34. KERKERING J, Muinjonov B, Rosiewicz KS, Diecke S, et al
    iPSC-derived reactive astrocytes from patients with multiple-sclerosis protect cocultured neurons in inflammatory conditions.
    J Clin Invest. 2023 May 23:e164637. doi: 10.1172/JCI164637.
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  35. EADE KT, Ansell BRE, Giles S, Fallon R, et al
    iPSC-derived retinal pigmented epithelial cells from patients with macular telangiectasia show decreased mitochondrial function.
    J Clin Invest. 2023;133:e163771.
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    February 2023
  36. MEERMEIER EW, Bergsagel PL
    Revisiting checkpoint inhibitors for myeloma: maintenance after stem cell transplant.
    J Clin Invest. 2023;133:e167346.
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  37. WANG YM, Taggart CB, Huber JF, Davies SM, et al
    Daytime-restricted parenteral feeding is associated with earlier oral intake in children following stem cell transplant.
    J Clin Invest. 2023;133:e167275.
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    January 2023
  38. LEE D, Gimple RC, Wu X, Prager BC, et al
    Superenhancer activation of KLHDC8A drives glioma ciliation and hedgehog signaling.
    J Clin Invest. 2023;133:e163592.
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    December 2022
  39. CHOI KM, Kim JJ, Yoo J, Kim KS, et al
    The interferon-inducible protein viperin controls cancer metabolic reprogramming to enhance cancer progression.
    J Clin Invest. 2022;132:e157302.
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  40. MINNIE SA, Waltner OG, Ensbey KS, Olver SD, et al
    TIGIT inhibition and lenalidomide synergistically promote anti-myeloma immune responses after stem cell transplantation in mice.
    J Clin Invest. 2022 Dec 13:e157907. doi: 10.1172/JCI157907.
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    November 2022
  41. LU C, Ma H, Song L, Wang H, et al
    IFNGR/STAT1 signaling in recipient hematopoietic antigen presenting cells suppresses graft-versus-host disease.
    J Clin Invest. 2022 Nov 29:e125986. doi: 10.1172/JCI125986.
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  42. KUROKAWA K, Wang TC, Hayakawa Y
    R-spondin 3 governs secretory differentiation in the gastric oxyntic glands.
    J Clin Invest. 2022;132.
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    October 2022
  43. YIN N, Jin G, Ma Y, Zhao H, et al
    SZT2 maintains hematopoietic stem cell homeostasis via nutrient-mediated mTORC1 regulation.
    J Clin Invest. 2022;132.
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    September 2022
  44. SCHUTT S, Wu Y, Kharel A, Bastian D, et al
    The druggable transcription factor Fli-1 regulates T cell immunity and tolerance in graft-versus-host disease.
    J Clin Invest. 2022 Sep 8. pii: 143950. doi: 10.1172/JCI143950.
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    August 2022
  45. DULMOVITS BM, Olson TS
    Does immune destruction drive all forms of bone marrow failure?
    J Clin Invest. 2022;132.
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    July 2022
  46. EVANS EJ JR, DeGregori J
    Dissecting stepwise mutational impairment of megakaryopoiesis in a model of Down syndrome-associated leukemia.
    J Clin Invest. 2022;132.
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  47. JAKUBISON BL, Sarkar T, Gudmundsson KO, Singh S, et al
    ID2 and HIF-1alpha collaborate to protect quiescent hematopoietic stem cells from activation, differentiation, and exhaustion.
    J Clin Invest. 2022;132.
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    June 2022
  48. SELLAR RS, Sperling AS, Slabicki M, Gasser JA, et al
    Degradation of GSPT1 causes TP53-independent cell death in leukemia whilst sparing normal hematopoietic stem cells.
    J Clin Invest. 2022 Jun 28. pii: 153514. doi: 10.1172/JCI153514.
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  49. FERRARA J, Prado-Acosta M
    Graft-versus-host disease: establishing IL-33 as an important costimulatory molecule.
    J Clin Invest. 2022;132.
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  50. LIN Q, Wu L, Chatla S, Chowdhury FA, et al
    Hematopoietic stem cell regeneration through paracrine regulation of the Wnt5a/Prox1 signaling axis.
    J Clin Invest. 2022;132.
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  51. GASPARINI SJ, Tessmer K, Reh M, Wieneke S, et al
    Transplanted human cones incorporate into the retina and function in a murine cone degeneration model.
    J Clin Invest. 2022;132.
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  52. CASADO JA, Valeri A, Sanchez-Dominguez R, Vela P, et al
    Upregulation of NKG2D ligands impairs hematopoietic stem cell function in Fanconi anemia.
    J Clin Invest. 2022 Jun 7. pii: 142842. doi: 10.1172/JCI142842.
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  53. WICKS EE, Semenza GL
    Hypoxia-inducible factors: cancer progression and clinical translation.
    J Clin Invest. 2022;132.
    >> Share

  54. LIANG J, Huang G, Liu X, Taghavifar F, et al
    The ZIP8/SIRT1 axis regulates alveolar progenitor cell renewal in aging and idiopathic pulmonary fibrosis.
    J Clin Invest. 2022;132.
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    May 2022
  55. KTENA YP, Koldobskiy MA, Barbato MI, Fu HH, et al
    Donor T-cell DNMT3a regulates alloreactivity in murine models of hematopoietic stem cell transplantation.
    J Clin Invest. 2022 May 24. pii: 158047. doi: 10.1172/JCI158047.
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  56. DWYER GK, Mathews LR, Villegas JA, Lucas A, et al
    IL-33 acts as a costimulatory signal to generate alloreactive Th1 cells in graft-versus-host disease.
    J Clin Invest. 2022 May 3. pii: 150927. doi: 10.1172/JCI150927.
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    February 2022
  57. JIANG L, Hao Y, Shao C, Wu Q, et al
    ADAR1-mediated RNA editing links ganglioside catabolism to glioblastoma stem cell maintenance.
    J Clin Invest. 2022 Feb 8. pii: 143397. doi: 10.1172/JCI143397.
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  58. BUTLER PC, Gale EA
    Reversing type 1 diabetes with stem cell-derived islets: a step closer to the dream?
    J Clin Invest. 2022;132.
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  59. SEEBAUER CT, Graus MS, Huang L, McCann A, et al
    Non-beta blocker enantiomers of propranolol and atenolol inhibit vasculogenesis in infantile hemangioma.
    J Clin Invest. 2022;132.
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    January 2022
  60. GUAN Y, Hasipek M, Jiang D, Tiwari AD, et al
    Eltrombopag inhibits TET dioxygenase to contribute to hematopoietic stem cell expansion in aplastic anemia.
    J Clin Invest. 2022 Jan 27. pii: 149856. doi: 10.1172/JCI149856.
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  61. OLIVA AD, Gupta R, Issa K, Abi Hachem R, et al
    Aging-related olfactory loss is associated with olfactory stem cell transcriptional alterations in humans.
    J Clin Invest. 2022 Jan 6. pii: 155506. doi: 10.1172/JCI155506.
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  62. LI Z, Duan H, Jia Y, Zhao C, et al
    Long-term corneal recovery by simultaneous delivery of hPSC-derived corneal endothelial precursors and nicotinamide.
    J Clin Invest. 2022;132.
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    November 2021
  63. PERSAUD SP, Ritchey JK, Kim S, Lim S, et al
    Antibody-drug conjugates plus Janus kinase inhibitors enable MHC-mismatched allogeneic hematopoietic stem cell transplantation.
    J Clin Invest. 2021 Nov 2. pii: 145501. doi: 10.1172/JCI145501.
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  64. TOKARZ VL, Delgado-Olguin P, Klip A
    Deprogram and reprogram to solve the riddle of insulin resistance.
    J Clin Invest. 2021;131.
    >> Share

  65. BRAEUER RR, Walker NM, Misumi K, Mazzoni-Putman S, et al
    Transcription factor FOXF1 identifies compartmentally distinct mesenchymal cells with a role in lung allograft fibrogenesis.
    J Clin Invest. 2021;131.
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    October 2021
  66. CHEN Z, Lu T, Huang L, Wang Z, et al
    Circular RNA cia-MAF drives self-renewal and metastasis of liver tumor-initiating cells via transcription factor MAFF.
    J Clin Invest. 2021;131.
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    August 2021
  67. QIAN J, LeSavage BL, Hubka KM, Ma C, et al
    Cancer-associated mesothelial cells promote ovarian cancer chemoresistance through paracrine osteopontin signaling.
    J Clin Invest. 2021;131.
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    June 2021
  68. TANG XY, Xu L, Wang J, Hong Y, et al
    DSCAM/PAK1 pathway suppression reverses neurogenesis deficits in iPSC-derived cerebral organoids from patients with Down syndrome.
    J Clin Invest. 2021;131.
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  69. LOONG JH, Wong TL, Tong M, Sharma R, et al
    Glucose deprivation-induced aberrant FUT1-mediated fucosylation drives cancer stemness in hepatocellular carcinoma.
    J Clin Invest. 2021;131.
    >> Share

    April 2021
  70. WANG L, Liu Y, Stratigopoulos G, Panigrahi S, et al
    Bardet-Biedl syndrome proteins regulate intracellular signaling and neuronal function in patient-specific iPSC-derived neurons.
    J Clin Invest. 2021;131.
    >> Share

    March 2021
  71. MUSCARELLA AM, Aguirre S, Hao X, Waldvogel SM, et al
    Exploiting bone niches: progression of disseminated tumor cells to metastasis.
    J Clin Invest. 2021;131.
    >> Share

  72. OSUKA S, Zhu D, Zhang Z, Li C, et al
    N-cadherin upregulation mediates adaptive radioresistance in glioblastoma.
    J Clin Invest. 2021;131.
    >> Share


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