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Articles published in
J Clin Invest
    October 2025
  1. DUVAL AJ, Seker-Polat F, Rogozinska M, Kinali M, et al
    SOX9 drives a stem-like transcriptional state and platinum resistance in high-grade serous ovarian cancer.
    J Clin Invest. 2025;135:e186467.
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    September 2025
  2. PARK SH, Cheon DH, Kim YM, Choi Y, et al
    NFAT5 dictates crosstalk between intestinal epithelial regenerative capacity and microbiota in murine colitis models.
    J Clin Invest. 2025;135:e183093.
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  3. JI L, Yan J, Losurdo NA, Wang H, et al
    Mutations in the spliceosomal gene SNW1 cause neurodevelopment disorders with microcephaly.
    J Clin Invest. 2025;135:e186119.
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  4. YANG J, Jiang Z, Fitzgerald DC, Ma C, et al
    Retraction of Adult neural stem cells expressing IL-10 confer potent immunomodulation and remyelination in experimental autoimmune encephalitis.
    J Clin Invest. 2025;135:e198608.
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  5. DENG Z, Law CS, Kurra S, Simchoni N, et al
    Activated STING in the thymic epithelium alters T cell development and selection leading to autoimmunity.
    J Clin Invest. 2025;135:e180252.
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  6. ORAVECZ-WILSON K, Lauder E, Taylor A, Maneix L, et al
    Corrigendum to Autophagy differentially regulates tissue tolerance of distinct target organs in graft-versus-host disease models.
    J Clin Invest. 2025;135:e198274.
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    August 2025
  7. XU T, Heon-Roberts R, Moore T, Dubot P, et al
    Neuraminidase 1 secondary deficiency contributes to CNS pathology in neurological mucopolysaccharidoses via brain protein hypersialylation.
    J Clin Invest. 2025;135:e177430.
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    July 2025
  8. SAKA S, Lu Z, Wang Y, Liu P, et al
    Chromatin factor YY1 controls fetal hematopoietic stem cell migration and engraftment in mice.
    J Clin Invest. 2025 Jul 29:e188140. doi: 10.1172/JCI188140.
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  9. SHAO JS, Lai AC, Huang WC, Wu KC, et al
    Pulmonary fibroblast-derived stem cell factor promotes neutrophilic asthma by augmenting IL-17A production from ILC3s.
    J Clin Invest. 2025 Jul 17:e187372. doi: 10.1172/JCI187372.
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  10. SINGH AK, Bernabucci M, Dvorak NM, Haghighijoo Z, et al
    Sensory neuron-expressed FGF13 controls nociceptive signaling in diabetic neuropathy models.
    J Clin Invest. 2025;135:e183749.
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  11. HUGHES EP, Syage AR, Mirzaei Mehrabad E, Lane TE, et al
    OCA-B promotes pathogenic maturation of stem-like CD4+ T cells and autoimmune demyelination.
    J Clin Invest. 2025;135:e187862.
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    June 2025
  12. TOMISHIMA SA, Kim DD, Porter N, Guha I, et al
    The E3 ubiquitin ligase Cul5 regulates hematopoietic stem cell function for steady-state hematopoiesis in mice.
    J Clin Invest. 2025 Jun 26:e180913. doi: 10.1172/JCI180913.
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    May 2025
  13. D'ADDIO F, Amabile G, Assi E, Maestroni A, et al
    TMEM219 signaling promotes intestinal stem cell death and exacerbates colitis.
    J Clin Invest. 2025;135:e185783.
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  14. SCHLEGEL N
    Promoting mucosal healing by targeting TMEM219-dependent intestinal epithelial stem cell defects in inflammatory bowel disease.
    J Clin Invest. 2025;135:e192640.
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  15. HUANG Y, Xie X, Liu M, Zhang Y, et al
    Restoring mitochondrial function promotes hematopoietic reconstitution from cord blood following cryopreservation-related functional decline.
    J Clin Invest. 2025;135:e183607.
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    April 2025
  16. GATTU AK, Tanzer M, Yaron-Barir TM, Johnson JL, et al
    Cell-intrinsic insulin signaling defects in human iPS cell-derived hepatocytes in type 2 diabetes.
    J Clin Invest. 2025;135:e183513.
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  17. GAO C, Dai Y, Spezza PA, Boasiako P, et al
    Megakaryocytes transfer mitochondria to bone marrow mesenchymal stromal cells to lower platelet activation.
    J Clin Invest. 2025;135:e189801.
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  18. KANG M, Choi J, Han J, Araki T, et al
    Aberrant ERK signaling in astrocytes impairs learning and memory in RASopathy-associated BRAF mutant mouse models.
    J Clin Invest. 2025;135:e176631.
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    March 2025
  19. DELAFONTAINE S, Meyts I
    Oncostatin M silence and neopeptide: the value of exploring patients with rare inherited bone marrow failure.
    J Clin Invest. 2025;135:e190955.
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    February 2025
  20. LI H, Liu P, Xu S, Li Y, et al
    FOXP1 controls mesenchymal stem cell commitment and senescence during skeletal aging.
    J Clin Invest. 2025;135:e191424.
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  21. WEI W, Gao X, Qian J, Li L, et al
    Beclin 1 prevents ISG15-mediated cytokine storms to secure fetal hematopoiesis and survival.
    J Clin Invest. 2025;135:e177375.
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    January 2025
  22. HAMAMOTO K, Zhu G, Lai Q, Lesperance J, et al
    HoxBlinc lncRNA reprograms CTCF-independent TADs to drive leukemic transcription and HSC dysregulation in NUP98-rearranged leukemia.
    J Clin Invest. 2025;135:e184743.
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  23. CUI X, Hou L, Yan B, Liu J, et al
    Sex dimorphism in the mouse bone marrow niche regulates hematopoietic engraftment via sex-specific Kdm5c/Cxcl12 signaling.
    J Clin Invest. 2025 Jan 21:e182125. doi: 10.1172/JCI182125.
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  24. GRIFFITH JW, Luster AD
    No bones about it: regulatory T cells promote fracture healing.
    J Clin Invest. 2025;135:e188368.
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  25. LI J, Bai J, Pham VT, Hashimoto M, et al
    Loss of Cpt1a results in elevated glucose-fueled mitochondrial oxidative phosphorylation and defective hematopoietic stem cells.
    J Clin Invest. 2025 Jan 9:e184069. doi: 10.1172/JCI184069.
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  26. CHEN S, Huang C, Li K, Cheng M, et al
    Tumor-initiating cells escape tumor immunity via CCL8 from tumor-associated macrophages in mice.
    J Clin Invest. 2025;135:e180893.
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  27. CHEN YT, Jiang MM, Leynes C, Adeyeye M, et al
    ATRX silences Cartpt expression in osteoblastic cells during skeletal development.
    J Clin Invest. 2025;135:e163587.
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  28. CAMPBELL K, Li Q
    Clonal hematopoiesis JAKs up plaque formation.
    J Clin Invest. 2025;135:e187529.
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  29. WANG BZ, Morsink MA, Kim SW, Luo LJ, et al
    Cardiac fibroblast BAG3 regulates TGFBR2 signaling and fibrosis in dilated cardiomyopathy.
    J Clin Invest. 2025;135:e181630.
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    December 2024
  30. SAARELA D, Lis P, Gomes S, Nirujogi RS, et al
    Tagless LysoIP for immunoaffinity enrichment of native lysosomes from clinical samples.
    J Clin Invest. 2024;135:e183592.
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  31. DEFAMIE V, Aliar K, Sarkar S, Vyas F, et al
    Metalloproteinase inhibitors regulate biliary progenitor cells through sDLK1 in organoid models of liver injury.
    J Clin Invest. 2024;135:e164997.
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  32. KIM Y, Kim SW, Saul D, Neyazi M, et al
    Regulation of sarcomere formation and function in the healthy heart requires a titin intronic enhancer.
    J Clin Invest. 2024;135:e183353.
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  33. WU Q, Yu C, Yu F, Guo Y, et al
    Evi1 governs Kdm6b-mediated histone demethylation to regulate the Laptm4b-driven mTOR pathway in hematopoietic progenitor cells.
    J Clin Invest. 2024;134:e173403.
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  34. PEACH T, Quattrocelli M
    The muscle stem cell case of Benjamin Button: rejuvenating muscle regenerative capacity through nutraceuticals.
    J Clin Invest. 2024;134:e185054.
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  35. WANG Q, Hu T, Zhang Q, Zhang Y, et al
    Fusobacterium nucleatum promotes colorectal cancer through neogenesis of tumor stem cells.
    J Clin Invest. 2024 Dec 10:e181595. doi: 10.1172/JCI181595.
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    November 2024
  36. NAYAK RC, Emberesh S, Trump LR, Wellendorf AM, et al
    G-CSF resistance of ELANE-mutant neutropenia depends on SERF1-containing truncated-neutrophil elastase aggregates.
    J Clin Invest. 2024;135:e177342.
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  37. WANG S, Huang T, Wu Q, Yuan H, et al
    Lactate reprograms glioblastoma immunity through CBX3-regulated histone lactylation.
    J Clin Invest. 2024;134:e176851.
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  38. ANCEL S, Michaud J, Migliavacca E, Jomard C, et al
    Nicotinamide and pyridoxine stimulate muscle stem cell expansion and enhance regenerative capacity during aging.
    J Clin Invest. 2024 Nov 12:e163648. doi: 10.1172/JCI163648.
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  39. PALLAVICINI G, Moccia A, Iegiani G, Parolisi R, et al
    Modeling primary microcephaly with human brain organoids reveals fundamental roles of CIT kinase activity.
    J Clin Invest. 2024;134:e175435.
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    October 2024
  40. LIU Q, Huang J, Ding H, Tao Y, et al
    Flavin-containing monooxygenase 2 confers cardioprotection in ischemia models through its disulfide bond catalytic activity.
    J Clin Invest. 2024;134:e177077.
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  41. SINHA S, Callow BW, Farfel AP, Roy S, et al
    Breast cancers that disseminate to bone marrow acquire aggressive phenotypes through CX43-related tumor-stroma tunnels.
    J Clin Invest. 2024;134:e170953.
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  42. GHOTBI E, Tchegnon E, Chen Z, Li S, et al
    Transcription factor KROX20 marks epithelial stem cells for hair follicle formation.
    J Clin Invest. 2024 Oct 3:e180160. doi: 10.1172/JCI180160.
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  43. CHEN CL, Tsukamoto H, Liu JC, Kashiwabara C, et al
    Reciprocal regulation by TLR4 and TGF-beta in tumor-initiating stem-like cells.
    J Clin Invest. 2024;134:e186923.
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    September 2024
  44. YANG H, Ping X, Zhou J, Ailifeire H, et al
    Reversible cold-induced lens opacity in a hibernator reveals a molecular target for treating cataracts.
    J Clin Invest. 2024;134:e169666.
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  45. LIU H, Zhao XF, Lu YN, Hayes LR, et al
    CRISPR/Cas13d targeting suppresses repeat-associated non-AUG translation of C9orf72 hexanucleotide repeat RNA.
    J Clin Invest. 2024;134:e179016.
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  46. DESCHAMPS P, Wacheux M, Gosseye A, Morabito M, et al
    CXCL8 secreted by immature granulocytes inhibits WT hematopoiesis in chronic myelomonocytic leukemia.
    J Clin Invest. 2024;134:e180738.
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  47. XING W, Feng H, Jiang B, Gao B, et al
    Itm2a expression marks periosteal skeletal stem cells that contribute to bone fracture healing.
    J Clin Invest. 2024;134:e176528.
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    August 2024
  48. BORDENAVE J, Gajda D, Michonneau D, Vallet N, et al
    Deciphering bone marrow engraftment after allogeneic stem cell transplantation in humans using single cell analyses.
    J Clin Invest. 2024 Aug 29:e180331. doi: 10.1172/JCI180331.
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  49. WALKER NM, Ibuki Y, McLinden AP, Misumi K, et al
    MNK-driven eIF4E phosphorylation regulates the fibrogenic transformation of mesenchymal cells and chronic lung allograft dysfunction.
    J Clin Invest. 2024;134:e168393.
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  50. SRIDHAR A, DeSantiago J, Chen H, Pavel MA, et al
    Modulation of NOX2 causes obesity-mediated atrial fibrillation.
    J Clin Invest. 2024;134:e175447.
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  51. SCHLEICHER WE, Hoag B, De Dominici M, DeGregori J, et al
    CHIP: a clonal odyssey of the bone marrow niche.
    J Clin Invest. 2024;134:e180068.
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    July 2024
  52. WU K, Zhang Y, Yin-DeClue H, Sun K, et al
    A correctable immune niche for epithelial stem-cell reprogramming and post-viral lung diseases.
    J Clin Invest. 2024 Jul 25:e183092. doi: 10.1172/JCI183092.
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    June 2024
  53. MAROM R, Song IW, Busse EC, Washington ME, et al
    The IFITM5 mutation in osteogenesis imperfecta type V is associated with an ERK/SOX9-dependent osteoprogenitor differentiation defect.
    J Clin Invest. 2024;134:e170369.
    >> Share

    May 2024
  54. SELGRADE DF, Fullenkamp DE, Chychula IA, Li B, et al
    Susceptibility to innate immune activation in genetically mediated myocarditis.
    J Clin Invest. 2024;134:e180254.
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  55. SAUL D, Doolittle ML, Rowsey JL, Froemming MN, et al
    Osteochondroprogenitor cells and neutrophils expressing p21 and senescence markers modulate fracture repair.
    J Clin Invest. 2024;134:e179834.
    >> Share

  56. LEOW DM, Ng YK, Wang LC, Koh HW, et al
    Hepatocyte-intrinsic SMN deficiency drives metabolic dysfunction and liver steatosis in spinal muscular atrophy.
    J Clin Invest. 2024;134:e173702.
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  57. LENARDIC A, Domenig SA, Zvick J, Bundschuh N, et al
    Generation of allogenic and xenogeneic functional muscle stem cells for intramuscular transplantation.
    J Clin Invest. 2024 May 7:e166998. doi: 10.1172/JCI166998.
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    April 2024
  58. MOE A, Rayasam A, Sauber G, Shah RK, et al
    Type 2 cannabinoid receptor expression on microglial cells regulates neuroinflammation during graft versus host disease.
    J Clin Invest. 2024 Apr 25:e175205. doi: 10.1172/JCI175205.
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  59. SONG X, Tiek D, Miki S, Huang T, et al
    RNA splicing analysis deciphers developmental hierarchies and reveals therapeutic targets in adult glioma.
    J Clin Invest. 2024;134:e173789.
    >> Share

  60. KEAN LS, Blazar BR
    Major breakthroughs in hematopoietic stem cell transplantation and future challenges in clinical implementation.
    J Clin Invest. 2024;134:e179944.
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  61. NORTH D, Chakraverty R
    The road to refractory graft-versus-host disease is paved with good intentions.
    J Clin Invest. 2024;134:e177728.
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  62. ZHANG P, Fleming P, Andoniou CE, Waltner OG, et al
    IL-6-mediated endothelial injury impairs antiviral humoral immunity after bone marrow transplantation.
    J Clin Invest. 2024;134:e174184.
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    March 2024
  63. MA H, Lu C, Ziegler J, Liu A, et al
    Absence of Stat1 in donor CD4+ T cells promotes the expansion of Tregs and reduces graft-versus-host disease in mice.
    J Clin Invest. 2024;134:e180350.
    >> Share

  64. ORAVECZ-WILSON K, Lauder E, Taylor A, Maneix L, et al
    Autophagy differentially regulates tissue tolerance of distinct target organs in graft-versus-host disease models.
    J Clin Invest. 2024;134:e167369.
    >> Share

    January 2024
  65. LUO M, Bao L, Xue Y, Zhu M, et al
    ZMYND8 protects breast cancer stem cells against oxidative stress and ferroptosis through activation of NRF2.
    J Clin Invest. 2024;134:e171166.
    >> Share


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