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Articles published in
Proc Natl Acad Sci U S A
    July 2025
  1. ZOU Y, Wang Z, Jiang Q, Kong X, et al
    UFMylation: A supervisor of the HIF1alpha pathway and a potential therapeutic target for anti-PD-1 combination therapy in hypoxic tumors.
    Proc Natl Acad Sci U S A. 2025;122:e2500562122.
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  2. SURYAWANSHI RK, Patil CD, Borase H, Shukla D, et al
    Akt isoform specificity drives intrinsic immune regulation during HSV-1 infection.
    Proc Natl Acad Sci U S A. 2025;122:e2504962122.
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  3. GUO J, Li K, Ming Y, Pan Y, et al
    A circular RNA overcomes acquired resistance to BET inhibitors by antagonizing IGF2BP2-mediated c-MYC translation in TNBC.
    Proc Natl Acad Sci U S A. 2025;122:e2504320122.
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  4. LIM J, Jung HD, Park SY, Jeon M, et al
    Genome-scale knockout simulation and clustering analysis of drug-resistant breast cancer cells reveal drug sensitization targets.
    Proc Natl Acad Sci U S A. 2025;122:e2425384122.
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    June 2025
  5. ZENG W, Guo H, Liu Q, Wong WH, et al
    Improving polygenic prediction from whole-genome sequencing data by leveraging predicted epigenomic features.
    Proc Natl Acad Sci U S A. 2025;122:e2419202122.
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  6. OZAKI MK, Zhang Y, Bartlett AQ, de Wilde E, et al
    Reproductive state controls transcription in the murine liver, with implications for breast cancer liver metastasis.
    Proc Natl Acad Sci U S A. 2025;122:e2420174122.
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  7. CROWTHER AJ, Kashem SW, Jewell ME, Le Chang H, et al
    Keratinocyte-TRPV1 sensory neuron interactions in a genetically controllable mouse model of chronic neuropathic itch.
    Proc Natl Acad Sci U S A. 2025;122:e2411724122.
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  8. DING Q, Liu J, Wang Y, Kim J, et al
    Dual-laser "808 and 1,064 nm" strategy that circumvents the Achilles' heel of photothermal therapy.
    Proc Natl Acad Sci U S A. 2025;122:e2503574122.
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  9. ZERILLO L, Zotti T, Tutela A, Madera JR, et al
    The CARD14sh-BCL10-MALT1 complex regulates MAVS-mediated antiviral response in keratinocytes.
    Proc Natl Acad Sci U S A. 2025;122:e2500711122.
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  10. SHARMA B, Aswin K, Jain T, Nasreen A, et al
    Mgat4b-mediated selective N-glycosylation regulates melanocyte development and melanoma progression.
    Proc Natl Acad Sci U S A. 2025;122:e2423831122.
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    May 2025
  11. FERRERO G, Cardamone MD, Luca F, Bourk E, et al
    Nonproteolytic ubiquitination regulates chromatin occupancy by the NCoR/SMRT/HDAC3 corepressor complex in MCF-7 breast cancer cells.
    Proc Natl Acad Sci U S A. 2025;122:e2502805122.
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    April 2025
  12. FOFFI E, Rugolo F, Ramamurthy N, Haight J, et al
    B cell-derived acetylcholine mitigates skin inflammation in mice through alpha9 nicotinic acetylcholine receptor-mediated signaling.
    Proc Natl Acad Sci U S A. 2025;122:e2501960122.
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  13. CHEN YF, Zhang QH, Zhang ZW, Zhou YJ, et al
    SNX10 deficiency impairs sensitivity to anti-HER2 antibody-drug conjugates via altering HER2 trafficking in HER2-positive breast cancer.
    Proc Natl Acad Sci U S A. 2025;122:e2417586122.
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  14. ZHAO X, Zhao Y, Li Z, Liu H, et al
    Proximity-activated DNA scanning encoded sequencing for massive access to membrane proteins nanoscale organization.
    Proc Natl Acad Sci U S A. 2025;122:e2425000122.
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    March 2025
  15. NAZERAI L, Tsiavou C, Vardouli L, Schmiegelow K, et al
    Thiopurine therapy enhances immune checkpoint inhibitor efficacy in low-mutational burden melanoma: A promising anticancer approach.
    Proc Natl Acad Sci U S A. 2025;122:e2423246122.
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  16. STAROSTECKA M, Jeong H, Hasenfeld P, Benito-Garagorri E, et al
    Structural variant and nucleosome occupancy dynamics postchemotherapy in a HER2+ breast cancer organoid model.
    Proc Natl Acad Sci U S A. 2025;122:e2415475122.
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    February 2025
  17. YI J, Du J, Chen X, Nie RC, et al
    A circRNA-mRNA pairing mechanism regulates tumor growth and endocrine therapy resistance in ER-positive breast cancer.
    Proc Natl Acad Sci U S A. 2025;122:e2420383122.
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  18. LEI L, Song Y, Yang L, Wang Y, et al
    Triethylamine-mediated protonation-deprotonation unlocks dual-drug self assembly to suppress breast cancer progression and metastasis.
    Proc Natl Acad Sci U S A. 2025;122:e2416796122.
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    January 2025
  19. KRAKOWIAK PA, Flores ME, Cuddy SR, Whitford AL, et al
    Co-option of mitochondrial nucleic acid-sensing pathways by HSV-1 UL12.5 for reactivation from latent infection.
    Proc Natl Acad Sci U S A. 2025;122:e2413965122.
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  20. CORRALES RM, Vincent J, Crobu L, Neish R, et al
    Tubulin detyrosination shapes Leishmania cytoskeletal architecture and virulence.
    Proc Natl Acad Sci U S A. 2025;122:e2415296122.
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  21. QIN G, Shao X, Liu X, Xu J, et al
    A signaling molecule from intratumor bacteria promotes trastuzumab resistance in breast cancer cells.
    Proc Natl Acad Sci U S A. 2025;122:e2421710122.
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  22. ZHENG M, Wang S, Tang K, Kong R, et al
    The CYLD-PARP1 feedback loop regulates DNA damage repair and chemosensitivity in breast cancer cells.
    Proc Natl Acad Sci U S A. 2025;122:e2413890121.
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    December 2024
  23. GONZALEZ-FERNANDEZ M, Perry C, Gerhards NM, Francica P, et al
    Docetaxel response in BRCA1,p53-deficient mammary tumor cells is affected by Huntingtin and BAP1.
    Proc Natl Acad Sci U S A. 2024;121:e2402849121.
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  24. CATTA-PRETA CMC, Ghosh K, Sacks DL, Ferreira TR, et al
    Single-cell atlas of Leishmania development in sandflies reveals the heterogeneity of transmitted parasites and their role in infection.
    Proc Natl Acad Sci U S A. 2024;121:e2406776121.
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  25. SINHA A, Saini KK, Chandramouli A, Tripathi K, et al
    ACSL4-mediated H3K9 and H3K27 hyperacetylation upregulates SNAIL to drive TNBC metastasis.
    Proc Natl Acad Sci U S A. 2024;121:e2408049121.
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  26. MATSUZAKI T, Fujii M, Noro H, Togo S, et al
    Simultaneous visualization of membrane fluidity and morphology defines adhesion signatures of cancer cells.
    Proc Natl Acad Sci U S A. 2024;121:e2412914121.
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  27. ROUBILLE S, Escure T, Juillard F, Corpet A, et al
    The HUSH epigenetic repressor complex silences PML nuclear body-associated HSV-1 quiescent genomes.
    Proc Natl Acad Sci U S A. 2024;121:e2412258121.
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    November 2024
  28. KASHYAP MP, Mishra B, Sinha R, Jin L, et al
    CD2 expressing innate lymphoid and T cells are critical effectors of immunopathogenesis in hidradenitis suppurativa.
    Proc Natl Acad Sci U S A. 2024;121:e2409274121.
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  29. LADAK RJ, Choi JH, Luo J, Chen OJ, et al
    The 4EHP-mediated translational repression of cGAS impedes the host immune response against DNA viruses.
    Proc Natl Acad Sci U S A. 2024;121:e2413018121.
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  30. DING X, Liang J, Sharko AC, Hilimire TA, et al
    Mediator kinase inhibitors suppress triple-negative breast cancer growth and extend tumor suppression by mTOR and AKT inhibitors.
    Proc Natl Acad Sci U S A. 2024;121:e2414501121.
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  31. ARULRAJ T, Wang H, Deshpande A, Varadhan R, et al
    Virtual patient analysis identifies strategies to improve the performance of predictive biomarkers for PD-1 blockade.
    Proc Natl Acad Sci U S A. 2024;121:e2410911121.
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    October 2024
  32. VALCIKOVA B, Vadovicova N, Smolkova K, Zacpalova M, et al
    eIF4F controls ERK MAPK signaling in melanomas with BRAF and NRAS mutations.
    Proc Natl Acad Sci U S A. 2024;121:e2321305121.
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  33. LI C, Kaur A, Pavlidaki A, Spenle C, et al
    Targeting the MAtrix REgulating MOtif abolishes several hallmarks of cancer, triggering antitumor immunity.
    Proc Natl Acad Sci U S A. 2024;121:e2404485121.
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  34. BALDASSARRI I, Tavakol DN, Graney PL, Chramiec AG, et al
    An engineered model of metastatic colonization of human bone marrow reveals breast cancer cell remodeling of the hematopoietic niche.
    Proc Natl Acad Sci U S A. 2024;121:e2405257121.
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  35. ASEMOTA S, Effah W, Holt J, Johnson D, et al
    A molecular switch from tumor suppressor to oncogene in ER+ve breast cancer: Role of androgen receptor, JAK-STAT, and lineage plasticity.
    Proc Natl Acad Sci U S A. 2024;121:e2406837121.
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    September 2024
  36. FENG X, Yang C, Huang Y, Su D, et al
    In vivo CRISPR screens identify Mga as an immunotherapy target in triple-negative breast cancer.
    Proc Natl Acad Sci U S A. 2024;121:e2406325121.
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  37. LOY CJ, Servellita V, Sotomayor-Gonzalez A, Bliss A, et al
    Plasma cell-free RNA signatures of inflammatory syndromes in children.
    Proc Natl Acad Sci U S A. 2024;121:e2403897121.
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    August 2024
  38. MUKOHARA F, Iwata K, Ishino T, Inozume T, et al
    Somatic mutations in tumor-infiltrating lymphocytes impact on antitumor immunity.
    Proc Natl Acad Sci U S A. 2024;121:e2320189121.
    >> Share

  39. PIRONON N, Bourrat E, Prost C, Chen M, et al
    Splice modulation strategy applied to deep intronic variants in COL7A1 causing recessive dystrophic epidermolysis bullosa.
    Proc Natl Acad Sci U S A. 2024;121:e2401781121.
    >> Share

  40. CHIANG HC, Qi L, Mitra P, Huang Y, et al
    R-loop functions in Brca1-associated mammary tumorigenesis.
    Proc Natl Acad Sci U S A. 2024;121:e2403600121.
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    July 2024
  41. SHAH OS, Nasrazadani A, Foldi J, Atkinson JM, et al
    Spatial molecular profiling of mixed invasive ductal and lobular breast cancers reveals heterogeneity in intrinsic molecular subtypes, oncogenic signatures, and mutations.
    Proc Natl Acad Sci U S A. 2024;121:e2322068121.
    >> Share

  42. ZIN I, China A, Khan K, Nag JK, et al
    AKT-dependent nuclear localization of EPRS1 activates PARP1 in breast cancer cells.
    Proc Natl Acad Sci U S A. 2024;121:e2303642121.
    >> Share

  43. ZHOU Q, Yu H, Chen Y, Ren J, et al
    The CRL3(KCTD10) ubiquitin ligase-USP18 axis coordinately regulates cystine uptake and ferroptosis by modulating SLC7A11.
    Proc Natl Acad Sci U S A. 2024;121:e2320655121.
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    June 2024
  44. DI LEO L, Pagliuca C, Kishk A, Rizza S, et al
    AMBRA1 levels predict resistance to MAPK inhibitors in melanoma.
    Proc Natl Acad Sci U S A. 2024;121:e2400566121.
    >> Share

  45. RUAN ML, Ni WX, Chu JCH, Lam TL, et al
    Iridium(III) carbene complexes as potent girdin inhibitors against metastatic cancers.
    Proc Natl Acad Sci U S A. 2024;121:e2316615121.
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  46. NEBO ID, Frew JW, Gudjonsson JE, Petukhova L, et al
    Tissue comparability and bias in hidradenitis suppurativa transcriptomic studies.
    Proc Natl Acad Sci U S A. 2024;121:e2404503121.
    >> Share

  47. JIN L, Kashyap MP, Haque ST, Li C, et al
    Reply to Nebo et al.: Pathogenesis of advanced hidradenitis suppurativa: Are there differences based on anatomical location, gender, and race?
    Proc Natl Acad Sci U S A. 2024;121:e2405298121.
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    May 2024

  48. Correction for Ichimura et al., Autoimmunity against melanoma differentiation-associated gene 5 induces interstitial lung disease mimicking dermatomyositis in mice.
    Proc Natl Acad Sci U S A. 2024;121:e2408646121.
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  49. CHEN J, Liu X, Zou Y, Gong J, et al
    A high-fat diet promotes cancer progression by inducing gut microbiota-mediated leucine production and PMN-MDSC differentiation.
    Proc Natl Acad Sci U S A. 2024;121:e2306776121.
    >> Share

  50. ASHOKAN A, Sarkar S, Kamran MZ, Surnar B, et al
    Simultaneous targeting of peripheral and brain tumors with a therapeutic nanoparticle to disrupt metabolic adaptability at both sites.
    Proc Natl Acad Sci U S A. 2024;121:e2318119121.
    >> Share

  51. GOYETTE MA, Stevens LE, DePinho CR, Seehawer M, et al
    Cancer-stromal cell interactions in breast cancer brain metastases induce glycocalyx-mediated resistance to HER2-targeting therapies.
    Proc Natl Acad Sci U S A. 2024;121:e2322688121.
    >> Share

    April 2024
  52. MONDAL DK, Xie C, Pascal GJ, Buraschi S, et al
    Decorin suppresses tumor lymphangiogenesis: A mechanism to curtail cancer progression.
    Proc Natl Acad Sci U S A. 2024;121:e2317760121.
    >> Share

  53. ICHIMURA Y, Konishi R, Shobo M, Tanaka R, et al
    Autoimmunity against melanoma differentiation-associated gene 5 induces interstitial lung disease mimicking dermatomyositis in mice.
    Proc Natl Acad Sci U S A. 2024;121:e2313070121.
    >> Share

  54. PIRES L, Khattak S, Pratavieira S, Calcada C, et al
    Femtosecond pulsed laser photodynamic therapy activates melanin and eradicates malignant melanoma.
    Proc Natl Acad Sci U S A. 2024;121:e2316303121.
    >> Share

    March 2024
  55. WANG D, Tang M, Zhang P, Yang K, et al
    Activation of ERbeta hijacks the splicing machinery to trigger R-loop formation in triple-negative breast cancer.
    Proc Natl Acad Sci U S A. 2024;121:e2306814121.
    >> Share

  56. GOUPIL E, Lacroix L, Briere J, Guga S, et al
    OSGN-1 is a conserved flavin-containing monooxygenase required to stabilize the intercellular bridge in late cytokinesis.
    Proc Natl Acad Sci U S A. 2024;121:e2308570121.
    >> Share

  57. TAYLOR-PHILLIPS S, Jenkinson D, Stinton C, Kunar MA, et al
    Fatigue and vigilance in medical experts detecting breast cancer.
    Proc Natl Acad Sci U S A. 2024;121:e2309576121.
    >> Share

  58. LAMIA KA
    Telling time in tumor samples reveals diversity of clock disruption.
    Proc Natl Acad Sci U S A. 2024;121:e2401496121.
    >> Share


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