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Articles published in
Proc Natl Acad Sci U S A
    November 2026
  1. HUANG L, Gao S, Li Q, Jin F, et al
    A glycan superbinder reveals polysialylated-CD56 as a precision biomarker for pancreatic cancer.
    Proc Natl Acad Sci U S A. 2026;123:e2611747123.
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  2. OMAR-HMEADI M, Matuseviciene L, Liu L, Lund PE, et al
    Pancreatic delta cells are resistant to auto- and paracrine inhibition in human type-2 diabetes.
    Proc Natl Acad Sci U S A. 2026;123:e2601168123.
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    October 2026
  3. SAKUMA S, Zhao S, Hildreth A, Liu G, et al
    Omega-3 fatty acids reprogram tumor-associated macrophage cytokine signaling and suppress pancreatic cancer growth.
    Proc Natl Acad Sci U S A. 2026;123:e2618288123.
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    September 2026
  4. JIANG Y, Pagen C, Yin G, Zhang Z, et al
    IRE1alpha-XBP1s signaling links lipid homeostasis to hypoxic maladaptation and KRAS inhibitor responses in pancreatic ductal adenocarcinoma.
    Proc Natl Acad Sci U S A. 2026;123:e2612523123.
    >> Share

  5. YANG F, Lin B, Yuan Y, Yuan Z, et al
    Inflammatory memory inactivates AMPK-stimulated DDR1 degradation to enable pancreatic cancer growth.
    Proc Natl Acad Sci U S A. 2026;123:e2616901123.
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  6. RAICH MK, Brauns F, Muller T, Reichert M, et al
    Multicellular rosette formation guides epithelial tissue assembly in pancreatic ductal adenocarcinoma cell organoids.
    Proc Natl Acad Sci U S A. 2026;123:e2512284123.
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  7. SHEN Y, Sun Q, Wang Y, Tian S, et al
    Targeting CTGF(+) cancer-associated fibroblasts disrupts tumor-stroma crosstalk in pancreatic ductal adenocarcinoma.
    Proc Natl Acad Sci U S A. 2026;123:e2535905123.
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    June 2026
  8. LIANG G, Nguyen HV, Zhu J, Tiriac H, et al
    HDAC inhibition sensitizes pancreatic tumors to DNA damage by global redistribution of the transcriptional machinery.
    Proc Natl Acad Sci U S A. 2026;123:e2536040123.
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  9. JANG I, Duffey A, Itkin-Ansari P, Arvan P, et al
    Coordinated expression and assembly of BiP, p58(IPK), and ER chaperone complexes maximize proinsulin folding in pancreatic beta cells.
    Proc Natl Acad Sci U S A. 2026;123:e2533617123.
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  10. LIAKI V, Barrambana S, Kostopoulou M, Lechuga CG, et al
    A targeted combination therapy achieves effective pancreatic cancer regression and prevents tumor resistance.
    Proc Natl Acad Sci U S A. 2026;123:e2610708123.
    >> Share

    May 2026
  11. TESTA E, Dezi C, Lovat F, Piro G, et al
    Fra-2 controls the response to the KRAS inhibitor MRTX-1133 in pancreatic ductal adenocarcinoma.
    Proc Natl Acad Sci U S A. 2026;123:e2601788123.
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  12. MILCAREK AT, Yeon M, Esposito C, Kulkarni P, et al
    Mitochondrial double-stranded RNA fuels pancreatic cancer growth via RIG-I/TLR3 inflammation.
    Proc Natl Acad Sci U S A. 2026;123:e2528281123.
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  13. Retraction for Liaki et al., A targeted combination therapy achieves effective pancreatic cancer regression and prevents tumor resistance.
    Proc Natl Acad Sci U S A. 2026;123:e2612385123.
    >> Share

    March 2026
  14. RAMSEY EL, Dobersch S, Freie B, Hong NH, et al
    MondoA mediates transcriptional coordination between the MYC network and the integrated stress response in pancreatic cancer.
    Proc Natl Acad Sci U S A. 2026;123:e2524659123.
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    February 2026
  15. ZHAO H, Chen H, Kang Z, Huang X, et al
    Genetic recording of pancreatic beta cell proliferation.
    Proc Natl Acad Sci U S A. 2026;123:e2507877123.
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    January 2026
  16. ANTONUCCI L, Watari K, Feng Y, Qi J, et al
    Selective targeting of NRF2-high pancreatic ductal adenocarcinoma with an NQO1-activatable prodrug.
    Proc Natl Acad Sci U S A. 2026;123:e2511733123.
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  17. LU H, Liu Y, Chiang HY, Zhang H, et al
    Exploring the interplay between protein conformational changes and phosphorylation in a pancreatic cancer cell and stellate cell coculture system.
    Proc Natl Acad Sci U S A. 2026;123:e2511839122.
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    December 2025
  18. LIAKI V, Barrambana S, Kostopoulou M, Lechuga CG, et al
    A targeted combination therapy achieves effective pancreatic cancer regression and prevents tumor resistance.
    Proc Natl Acad Sci U S A. 2025;122:e2523039122.
    >> Share

    November 2025
  19. LI YR, Shen X, Zhu E, Li Z, et al
    Targeting orthotopic and metastatic pancreatic cancer with allogeneic stem cell-engineered mesothelin-redirected CAR-NKT cells.
    Proc Natl Acad Sci U S A. 2025;122:e2517786122.
    >> Share

  20. YANG X, Wang Y, Zhou J, Li S, et al
    Engineering a spatiotemporal macrophage circuit via STING phase separation to override immune suppression in pancreatic cancer.
    Proc Natl Acad Sci U S A. 2025;122:e2504718122.
    >> Share

    September 2025
  21. CHUANG PK, Chung C, Liao KS, Wong CH, et al
    Improving the efficacy of anti-SSEA4 antibody in pancreatic cancer immunotherapy with glyco-optimization and immune checkpoint blockade.
    Proc Natl Acad Sci U S A. 2025;122:e2517415122.
    >> Share

    August 2025
  22. YUAN S, Yang X, Bremmer AM, Wang Y, et al
    Programmable immunoprobiotics orchestrate antitumor immune response with Pin1 inhibition for pancreatic cancer treatment.
    Proc Natl Acad Sci U S A. 2025;122:e2507711122.
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    July 2025
  23. MORESCO P, Kastan JP, Yang JI, Prabakar R, et al
    Signal peptide-independent secretion of keratin-19 by pancreatic cancer cells.
    Proc Natl Acad Sci U S A. 2025;122:e2426218122.
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    April 2025
  24. VINAIXA J, Martinez-Bosch N, Gibert J, Manero-Ruperez N, et al
    Nuclear Galectin-1 promotes KRAS-dependent activation of pancreatic cancer stellate cells.
    Proc Natl Acad Sci U S A. 2025;122:e2424051122.
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    March 2025
  25. ZHU Q, Yu C, Chen Y, Luo W, et al
    Dual mRNA nanoparticles strategy for enhanced pancreatic cancer treatment and beta-elemene combination therapy.
    Proc Natl Acad Sci U S A. 2025;122:e2418306122.
    >> Share

    October 2024
  26. YANG Y, Wang B, Dong H, Lin H, et al
    The mitochondrial enzyme pyruvate carboxylase restricts pancreatic beta-cell senescence by blocking p53 activation.
    Proc Natl Acad Sci U S A. 2024;121:e2401218121.
    >> Share

    August 2024
  27. KITAMURA RA, Hummel D, Ustione A, Piston DW, et al
    Dual role of neuroplastin in pancreatic beta cells: Regulating insulin secretion and promoting islet inflammation.
    Proc Natl Acad Sci U S A. 2024;121:e2411234121.
    >> Share

  28. SU W, Kochen Rossi J, Nuevo-Tapioles C, Chen T, et al
    UPF1 deficiency enhances mitochondrial ROS which promotes an immunosuppressive microenvironment in pancreatic ductal adenocarcinoma.
    Proc Natl Acad Sci U S A. 2024;121:e2401996121.
    >> Share

    July 2024
  29. AMIT U, Uslu U, Verginadis II, Kim MM, et al
    Proton radiation boosts the efficacy of mesothelin-targeting chimeric antigen receptor T cell therapy in pancreatic cancer.
    Proc Natl Acad Sci U S A. 2024;121:e2403002121.
    >> Share

  30. LI J, Moresco P, Fearon DT
    Intratumoral NKT cell accumulation promotes antitumor immunity in pancreatic cancer.
    Proc Natl Acad Sci U S A. 2024;121:e2403917121.
    >> Share

    April 2024
  31. HIYOSHI H, Sakuma K, Asano S, Napier SC, et al
    Identification and removal of unexpected proliferative off-target cells emerging after iPSC-derived pancreatic islet cell implantation.
    Proc Natl Acad Sci U S A. 2024;121:e2320883121.
    >> Share

  32. MURTHY D, Attri KS, Suresh V, Rajacharya GH, et al
    The MUC1-HIF-1alpha signaling axis regulates pancreatic cancer pathogenesis through polyamine metabolism remodeling.
    Proc Natl Acad Sci U S A. 2024;121:e2315509121.
    >> Share

    August 2023
  33. DASGUPTA A, Gibbard DF, Schmitt RE, Arneson-Wissink PC, et al
    A TGF-beta/KLF10 signaling axis regulates atrophy-associated genes to induce muscle wasting in pancreatic cancer.
    Proc Natl Acad Sci U S A. 2023;120:e2215095120.
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    May 2023
  34. CHANDA D, Thoudam T, Sinam IS, Lim CW, et al
    Upregulation of the ERRgamma-VDAC1 axis underlies the molecular pathogenesis of pancreatitis.
    Proc Natl Acad Sci U S A. 2023;120:e2219644120.
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    March 2023

  35. Correction for Taylor et al., Human pancreatic islet microRNAs implicated in diabetes and related traits by large-scale genetic analysis.
    Proc Natl Acad Sci U S A. 2023;120:e2302726120.
    >> Share

  36. MELLO SS, Flowers BM, Mazur PK, Lee JJ, et al
    Multifaceted role for p53 in pancreatic cancer suppression.
    Proc Natl Acad Sci U S A. 2023;120:e2211937120.
    >> Share


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