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Articles published in
J Gastroenterol
    March 2026
  1. KOYAMA K, Takahashi K, Ono Y, Oyama K, et al
    Extracellular vesicle-encapsulated microRNA-425 promotes tumor development and serves as a biomarker for pancreatic ductal adenocarcinoma.
    J Gastroenterol. 2026 Mar 10. doi: 10.1007/s00535-026-02382.
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  2. KOYAMA T, Nawa N, Nishimura H, Hanafusa M, et al
    Regional differences for the risk of in-hospital mortality after pancreaticoduodenectomy: a cross-sectional study analyzing data from a Japanese nationwide database including 86,339 patients.
    J Gastroenterol. 2026 Mar 2. doi: 10.1007/s00535-026-02357.
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    February 2026
  3. NISHIDA T, Sugimoto A, Matsumoto K
    Prognostic value of functional assessment in sarcopenia among pancreatic cancer patients.
    J Gastroenterol. 2026 Feb 27. doi: 10.1007/s00535-026-02376.
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  4. SHIMAMOTO N, Sumiyama K, Fujita Y
    Extracellular vesicle biomarkers in pancreatic ductal adenocarcinoma: from bulk detection to single-extracellular vesicle profiling and endoscopic liquid biopsy.
    J Gastroenterol. 2026 Feb 6. doi: 10.1007/s00535-026-02350.
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  5. YANG A, Pan C, Gu C, Luo B, et al
    YAP1-driven tumor-like cancer-associated fibroblasts modulate biomechanics of pancreatic ductal adenocarcinoma.
    J Gastroenterol. 2026 Feb 3. doi: 10.1007/s00535-026-02346.
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  6. ROBATEL S, Hillen H, Mutisheva I, Muller JC, et al
    Agonistic GITR treatment enhances antitumor immune responses and suppresses tumor progression in pancreatic ductal adenocarcinoma.
    J Gastroenterol. 2026 Feb 1. doi: 10.1007/s00535-026-02347.
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    January 2026
  7. REN H, Fei H, Niu P, Xu X, et al
    An interpretable machine learning model for predicting survival in pancreatic cancer via SHAP: a multicenter study.
    J Gastroenterol. 2026 Jan 30. doi: 10.1007/s00535-026-02348.
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  8. UEMATSU Y, Matsuda S, Kitago M, Uemura S, et al
    Preoperative CD44v6-positive extracellular vesicles as a prognostic biomarker in pancreatic ductal adenocarcinoma.
    J Gastroenterol. 2026 Jan 11. doi: 10.1007/s00535-026-02343.
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  9. IKEMOTO J, Ishii Y, Hanada K, Sasaki T, et al
    Clinical outcomes and recurrence patterns in pancreatic ductal adenocarcinoma diagnosed at an early stage: insights from a multicenter cohort study in Japan.
    J Gastroenterol. 2026 Jan 3. doi: 10.1007/s00535-025-02340.
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    November 2025
  10. ZHU M, Douchi D, Murakami K, Itoh T, et al
    Correction: Molecular insights into HER2/ERBB2 amplification and carcinogenesis in gallbladder cancer associated with pancreaticobiliary maljunction.
    J Gastroenterol. 2025 Nov 26. doi: 10.1007/s00535-025-02329.
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  11. MATSUMOTO R, Kikuta K, Takikawa T, Nakai Y, et al
    Mortality and cancer risk in patients with chronic pancreatitis in japan: insights into the importance of surveillance for pancreatic cancer.
    J Gastroenterol. 2025 Nov 18. doi: 10.1007/s00535-025-02321.
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  12. MASAMUNE A, Masson E, Zou WB, Rygiel AM, et al
    TRPV6-related pancreatitis: natural history and the impact of the pancreas-specific deletion on pancreatitis in mice.
    J Gastroenterol. 2025 Nov 17. doi: 10.1007/s00535-025-02323.
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  13. HAYASHI N, Takahara T, Yasuda I, Kawanaka H, et al
    Development of novel serum peptide biomarkers for screening pancreatic cancer.
    J Gastroenterol. 2025 Nov 5. doi: 10.1007/s00535-025-02314.
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    October 2025
  14. ZHU M, Douchi D, Murakami K, Itoh T, et al
    Molecular insights into HER2/ERBB2 amplification and carcinogenesis in gallbladder cancer associated with pancreaticobiliary maljunction.
    J Gastroenterol. 2025 Oct 4. doi: 10.1007/s00535-025-02303.
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    September 2025
  15. WANG X, Zhang Y, Li A, Zhou C, et al
    STYK1 as a targetable vulnerability enhances the efficacy of anti-PD-L1 therapy in pancreatic cancer.
    J Gastroenterol. 2025 Sep 19. doi: 10.1007/s00535-025-02291.
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    July 2025
  16. TANAKA Y, Masamune A, Matsumoto R, Takikawa T, et al
    Nationwide epidemiological survey of acute pancreatitis in Japan, 2021: the impact of the COVID-19 pandemic and revised clinical guidelines.
    J Gastroenterol. 2025 Jul 31. doi: 10.1007/s00535-025-02284.
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  17. EMORI T, Itonaga M, Ashida R, Ishihara T, et al
    Impact of sarcopenia and changes in skeletal muscle mass on prognosis of patients with pancreatic ductal adenocarcinoma receiving chemotherapy with first-line gemcitabine and nab-paclitaxel: a prospective study.
    J Gastroenterol. 2025 Jul 17. doi: 10.1007/s00535-025-02283.
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    June 2025
  18. LIU S, Su J, Zhao H, Bai R, et al
    Correction: Identification of novel plasma proteins as promising noninvasive biomarker for early diagnosis and surveillance of pancreatic ductal adenocarcinoma.
    J Gastroenterol. 2025 Jun 27. doi: 10.1007/s00535-025-02274.
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  19. LEI S, Zhang Z, Zeng Z, Cao W, et al
    aGenome-scale activation screen reveals lncRNA HNF1A-AS1 promotes pancreatic cancer metastasis through interacting with U2SURP to increase CD44 alternative splicing.
    J Gastroenterol. 2025 Jun 15. doi: 10.1007/s00535-025-02272.
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    May 2025
  20. NISHIWADA S, Nakamura K, Ozu N, Terai T, et al
    An axon guidance-related microRNA panel identifies perivascular plexus local recurrence following curative surgery in patients with pancreatic cancer.
    J Gastroenterol. 2025 May 10. doi: 10.1007/s00535-025-02260.
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  21. ENDO G, Ishigaki K, Nakai Y, Nishio H, et al
    Factors associated with actionable gene aberrations in pancreatic cancer based on the C-CAT database.
    J Gastroenterol. 2025 May 2. doi: 10.1007/s00535-025-02253.
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  22. MANAKA T, Takikawa T, Tarasawa K, Kikuta K, et al
    Current status and trends in ERCP and post-ERCP pancreatitis in Japan: a nationwide observational study.
    J Gastroenterol. 2025 May 2. doi: 10.1007/s00535-025-02254.
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    April 2025
  23. LIU S, Su J, Zhao H, Bai R, et al
    Identification of novel plasma proteins as promising noninvasive biomarker for early diagnosis and surveillance of pancreatic ductal adenocarcinoma.
    J Gastroenterol. 2025 Apr 26. doi: 10.1007/s00535-025-02252.
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    March 2025
  24. WU Z, Yang J, Ma Z, Chen Y, et al
    Nuclear magnetic resonance-based metabolomics and risk of pancreatic cancer: a prospective analysis in the UK Biobank.
    J Gastroenterol. 2025 Mar 12. doi: 10.1007/s00535-025-02237.
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    January 2025
  25. ABU-SERIE MM, Gutierrez-Garcia AK, Enman M, Vaish U, et al
    Ferroptosis- and stemness inhibition-mediated therapeutic potency of ferrous oxide nanoparticles-diethyldithiocarbamate using a co-spheroid 3D model of pancreatic cancer.
    J Gastroenterol. 2025 Jan 31. doi: 10.1007/s00535-025-02213.
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  26. IMAOKA H, Ikeda M, Kobayashi S, Ohba A, et al
    Correction: Efficacy of liposomal irinotecan + 5-FU/LV vs. S-1 in gemcitabine-refractory metastatic pancreatic cancer: a real-world study using inverse probability of treatment weighting.
    J Gastroenterol. 2025 Jan 29. doi: 10.1007/s00535-025-02215.
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  27. HU K, Zhao X, Zhang N, Ma J, et al
    Effect of tumor microenvironment in pancreatic cancer on the loss of beta-cell mass: implications for type 3c diabetes.
    J Gastroenterol. 2025 Jan 6. doi: 10.1007/s00535-024-02204.
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    December 2024
  28. DEVASAHAYAM AROKIA BALAYA R, Sen P, Grant CW, Zenka R, et al
    An integrative multi-omics analysis reveals a multi-analyte signature of pancreatic ductal adenocarcinoma in serum.
    J Gastroenterol. 2024 Dec 12. doi: 10.1007/s00535-024-02197.
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  29. KUGIYAMA N, Nagaoka K, Yamada R, Watanabe T, et al
    Serum Mac2-binding protein glycosylated isomer (M2BPGi) as a prognostic biomarker in pancreatic ductal adenocarcinoma: iCAFs-derived M2BPGi drives tumor invasion.
    J Gastroenterol. 2024 Dec 11. doi: 10.1007/s00535-024-02195.
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  30. NOTOYA G, Kishikawa T, Yasugi K, Iwata T, et al
    WWP1 inhibition suppresses the proliferation of pancreatic cancer cells by regulating the PI3K-AKT pathway.
    J Gastroenterol. 2024 Dec 10. doi: 10.1007/s00535-024-02192.
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    November 2024
  31. IMAOKA H, Ikeda M, Kobayashi S, Ohba A, et al
    Efficacy of liposomal irinotecan + 5-FU/LV vs. S-1 in gemcitabine-refractory metastatic pancreatic cancer: a real-world study using inverse probability of treatment weighting.
    J Gastroenterol. 2024 Nov 30. doi: 10.1007/s00535-024-02186.
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  32. ISHIGAKI K, Tokito Y, Takahara N, Nishio H, et al
    Association between homologous recombination deficiency and time to treatment failure to platinum-based chemotherapy for pancreatic cancer by using the C-CAT database.
    J Gastroenterol. 2024 Nov 21. doi: 10.1007/s00535-024-02173.
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    September 2024
  33. MIKI M, Masuda A, Takenaka M, Shiomi H, et al
    Association of pancreatic atrophy patterns with intraductal extension of early pancreatic ductal adenocarcinoma: a multicenter retrospective study.
    J Gastroenterol. 2024 Sep 16. doi: 10.1007/s00535-024-02149.
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    August 2024
  34. WANG P, Huang B, Liu Y, Tan X, et al
    Corynoline protects chronic pancreatitis via binding to PSMA2 and alleviating pancreatic fibrosis.
    J Gastroenterol. 2024 Aug 15. doi: 10.1007/s00535-024-02145.
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    June 2024
  35. HIDAKA Y, Tanoue S, Ayukawa T, Takumi K, et al
    Impact of pancreatic ductal occlusion on postoperative outcomes in pancreatic head cancer patients undergoing neoadjuvant therapy.
    J Gastroenterol. 2024 Jun 20. doi: 10.1007/s00535-024-02125.
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  36. MINAGA K, Otsuka Y, Watanabe T
    High-mobility group box 1: friend or foe in pancreatitis.
    J Gastroenterol. 2024 Jun 17. doi: 10.1007/s00535-024-02123.
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  37. ZHAO LJ, Chen P, Huang L, He WQ, et al
    Heparan sulfate acts as an activator of the NLRP3 inflammasome promoting inflammatory response in the development of acute pancreatitis.
    J Gastroenterol. 2024 Jun 12. doi: 10.1007/s00535-024-02127.
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    May 2024
  38. HOKKOKU D, Sasaki K, Kobayashi S, Shimbo T, et al
    High-mobility group box 1 fragment ameliorates chronic pancreatitis induced by caerulein in mice.
    J Gastroenterol. 2024 May 10. doi: 10.1007/s00535-024-02112.
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    April 2024
  39. MATSUMOTO K, Fujimori N, Ichihara K, Takeno A, et al
    Patient-derived organoids of pancreatic ductal adenocarcinoma for subtype determination and clinical outcome prediction.
    J Gastroenterol. 2024 Apr 29. doi: 10.1007/s00535-024-02103.
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    February 2024
  40. NAGAO K, Sakai A, Tsumura H, Iemoto T, et al
    Pancreatic injury in patients treated with immune checkpoint inhibitors: a retrospective multicenterstudy.
    J Gastroenterol. 2024 Feb 29. doi: 10.1007/s00535-024-02083.
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    January 2024
  41. KASHIRO A, Kobayashi M, Oh T, Miyamoto M, et al
    Clinical development of a blood biomarker using apolipoprotein-A2 isoforms for early detection of pancreatic cancer.
    J Gastroenterol. 2024 Jan 23. doi: 10.1007/s00535-023-02072.
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  42. ABE S, Masuda A, Matsumoto T, Inoue J, et al
    Impact of intratumoral microbiome on tumor immunity and prognosis in human pancreatic ductal adenocarcinoma.
    J Gastroenterol. 2024 Jan 20. doi: 10.1007/s00535-023-02069.
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    November 2023
  43. SAKAKIDA T, Ishikawa T, Doi T, Morita R, et al
    Genomic profile and clinical features of MSI-H and TMB-high pancreatic cancers: real-world data from C-CAT database.
    J Gastroenterol. 2023 Nov 25. doi: 10.1007/s00535-023-02058.
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  44. TAKEUCHI C, Sato J, Yamamichi N, Kageyama-Yahara N, et al
    Marked intestinal trans-differentiation by autoimmune gastritis along with ectopic pancreatic and pulmonary trans-differentiation.
    J Gastroenterol. 2023 Nov 14. doi: 10.1007/s00535-023-02055.
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    September 2023
  45. OZONO Y, Kawakami H, Uchiyama N, Hatada H, et al
    Current status and issues in genomic analysis using EUS-FNA/FNB specimens in hepatobiliary-pancreatic cancers.
    J Gastroenterol. 2023 Sep 12. doi: 10.1007/s00535-023-02037.
    >> Share

  46. OKUSAKA T, Saiura A, Shimada K, Ikeda M, et al
    Incidence and risk factors for venous thromboembolism in the Cancer-VTE Registry pancreatic cancer subcohort.
    J Gastroenterol. 2023 Sep 7. doi: 10.1007/s00535-023-02033.
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    August 2023
  47. FISCHMAN M, Elias A, Klein A, Cohen Y, et al
    The association between phosphate level at admission and early mortality in acute pancreatitis.
    J Gastroenterol. 2023 Aug 18. doi: 10.1007/s00535-023-02034.
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    July 2023
  48. OYAMA H, Hamada T, Nakai Y, Tanaka M, et al
    Clinical trajectory of intraductal papillary mucinous neoplasms progressing to pancreatic carcinomas during long-term surveillance: a prospective series of 100 carcinoma cases.
    J Gastroenterol. 2023 Jul 29. doi: 10.1007/s00535-023-02028.
    >> Share

  49. ASHINA S, Masuda A, Yamakawa K, Hamada T, et al
    A comprehensive analysis of tumor-stromal collagen in relation to pathological, molecular, and immune characteristics and patient survival in pancreatic ductal adenocarcinoma.
    J Gastroenterol. 2023 Jul 21. doi: 10.1007/s00535-023-02020.
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    June 2023
  50. TOMIMARU Y, Eguchi H, Shimomura Y, Kitamura T, et al
    Standard versus delayed initiation of S-1 adjuvant chemotherapy after surgery for pancreatic cancer: a secondary analysis of a nationwide cohort by the Japan Pancreas Society.
    J Gastroenterol. 2023 Jun 17. doi: 10.1007/s00535-023-01988.
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    May 2023
  51. KAWASAKI Y, Hijioka S, Nagashio Y, Maruki Y, et al
    Efficacy of endoscopic ultrasound-guided tissue acquisition for solid pancreatic lesions 20 mm or less in diameter suspected as neuroendocrine tumors or requiring differentiation.
    J Gastroenterol. 2023 May 8. doi: 10.1007/s00535-023-01995.
    >> Share

    April 2023
  52. SAKAI A, Masuda A, Kodama Y
    Does early intervention for infected pancreatic necrosis lead to better clinical outcomes compared to delayed intervention?
    J Gastroenterol. 2023 Apr 30. doi: 10.1007/s00535-023-01994.
    >> Share

  53. MURAKAMI M, Fujimori N, Nakata K, Nakamura M, et al
    Machine learning-based model for prediction and feature analysis of recurrence in pancreatic neuroendocrine tumors G1/G2.
    J Gastroenterol. 2023 Apr 26. doi: 10.1007/s00535-023-01987.
    >> Share

  54. SAKAKIDA T, Ishikawa T, Doi T, Morita R, et al
    Genomic landscape and clinical features of rare subtypes of pancreatic cancer: analysis with the national database of Japan.
    J Gastroenterol. 2023 Apr 7. doi: 10.1007/s00535-023-01986.
    >> Share


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