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Articles published in
Proc Natl Acad Sci U S A
    September 2025
  1. ZHANG X, Liu Q, Liu C, Wang Z, et al
    Oxytocin and vasopressin enhance social pain empathy via common and distinct of neural expressions, genetic pathways, and networks.
    Proc Natl Acad Sci U S A. 2025;122:e2520651122.
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    August 2025
  2. WANG C, Ji H, Wang H, Chen Z, et al
    Unraveling the neuroimmune mechanisms in cancer-induced bone pain: New horizons for therapeutic intervention of the two-phase paradigm.
    Proc Natl Acad Sci U S A. 2025;122:e2503779122.
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    July 2025
  3. KANG SJ, Liu S, Kim JH, Kim DI, et al
    Thalamic CGRP neurons define a spinothalamic pathway for affective pain.
    Proc Natl Acad Sci U S A. 2025;122:e2505889122.
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  4. LANCON K, Tian J, Bach H, Drapeau P, et al
    Synergistic deficits in parvalbumin interneurons and dopamine signaling drive ACC dysfunction in chronic pain.
    Proc Natl Acad Sci U S A. 2025;122:e2502558122.
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  5. WAXMAN SG, Vasylyev DV
    Inhibiting Nav1.8 for pain: Lessons from patients and from neurons.
    Proc Natl Acad Sci U S A. 2025;122:e2511228122.
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    May 2025
  6. STRATTON HJ, Dolatyari M, Kopruszinski C, Ghetti A, et al
    A prolactin-targeting antibody to prevent stress-induced peripheral nociceptor sensitization and female postoperative pain.
    Proc Natl Acad Sci U S A. 2025;122:e2501229122.
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    March 2025
  7. TOBORI S, Tamada K, Uemura N, Sawada K, et al
    Spinal TRPC3 promotes neuropathic pain and coordinates phospholipase C-induced mechanical hypersensitivity.
    Proc Natl Acad Sci U S A. 2025;122:e2416828122.
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  8. OGGERO S, Voisin MB, Picco F, Huerta MA, et al
    Activation of proresolving macrophages in dorsal root ganglia attenuates persistent arthritis pain.
    Proc Natl Acad Sci U S A. 2025;122:e2416343122.
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    January 2025
  9. WIRT JL, Assis Ferreira L, Jesus CHA, Woodward TJ, et al
    Efficacy of GABA aminotransferase inactivator OV329 in models of neuropathic and inflammatory pain without tolerance or addiction.
    Proc Natl Acad Sci U S A. 2025;122:e2318833121.
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    December 2024
  10. PATTISON LA, Rickman RH, Hilton H, Dannawi M, et al
    Activation of the proton-sensing GPCR, GPR65 on fibroblast-like synoviocytes contributes to inflammatory joint pain.
    Proc Natl Acad Sci U S A. 2024;121:e2410653121.
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    November 2024
  11. CHEN T, Liu WB, Zhu SJ, Aji A, et al
    Differential modulation of pain and associated anxiety by GABAergic neuronal circuits in the lateral habenula.
    Proc Natl Acad Sci U S A. 2024;121:e2409443121.
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    October 2024
  12. CHANG D, Caterina MJ
    Pinning down a perpetrator in postsurgical eye pain.
    Proc Natl Acad Sci U S A. 2024;121:e2417221121.
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    August 2024
  13. GARZA-CARBAJAL A, Bavencoffe A, Herrera JJ, Johnson KN, et al
    Mechanism of gabapentinoid potentiation of opioid effects on cyclic AMP signaling in neuropathic pain.
    Proc Natl Acad Sci U S A. 2024;121:e2405465121.
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  14. GUZIKEVITS M, Gordon-Hecker T, Rekhtman D, Salameh S, et al
    Sex bias in pain management decisions.
    Proc Natl Acad Sci U S A. 2024;121:e2401331121.
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    July 2024
  15. QIU H, Miraucourt LS, Petitjean H, Xu M, et al
    Parvalbumin gates chronic pain through the modulation of firing patterns in inhibitory neurons.
    Proc Natl Acad Sci U S A. 2024;121:e2403777121.
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    June 2024
  16. LEE SA, Lee JJ, Han J, Choi M, et al
    Brain representations of affective valence and intensity in sustained pleasure and pain.
    Proc Natl Acad Sci U S A. 2024;121:e2310433121.
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    February 2024
  17. HUANG Z, Zhang Y, Wang S, Qi R, et al
    FOXD3-mediated transactivation of ALKBH5 promotes neuropathic pain via m(6)A-dependent stabilization of 5-HT3A mRNA in sensory neurons.
    Proc Natl Acad Sci U S A. 2024;121:e2312861121.
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    December 2023
  18. YOUSUF MS, Sahn JJ, Yang H, David ET, et al
    Highly specific sigma(2)R/TMEM97 ligand FEM-1689 alleviates neuropathic pain and inhibits the integrated stress response.
    Proc Natl Acad Sci U S A. 2023;120:e2306090120.
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  19. CHEN M, Shin M, Ware TB, Donvito G, et al
    Endocannabinoid biosynthetic enzymes regulate pain response via LKB1-AMPK signaling.
    Proc Natl Acad Sci U S A. 2023;120:e2304900120.
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    November 2023
  20. GOMEZ K, Santiago U, Nelson TS, Allen HN, et al
    A peptidomimetic modulator of the Ca(V)2.2 N-type calcium channel for chronic pain.
    Proc Natl Acad Sci U S A. 2023;120:e2305215120.
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