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Multiple Sclerosis

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Articles published in
J Clin Invest
    May 2024
  1. GHORBANI S, Li C, Lozinski BM, Moezzi D, et al
    Fibulin-2 is an extracellular matrix inhibitor of oligodendrocytes relevant to multiple sclerosis.
    J Clin Invest. 2024 May 14:e176910. doi: 10.1172/JCI176910.
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    December 2023
  2. JOHANN L, Soldati S, Muller K, Lampe J, et al
    A20 regulates lymphocyte adhesion in murine neuroinflammation by restricting endothelial ICOSL expression in the CNS.
    J Clin Invest. 2023;133:e168314.
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    September 2023
  3. CLARKSON BD, Grund EM, Standiford MM, Mirchia K, et al
    CD8+ T cells recognizing a neuron-restricted antigen injure axons in a model of multiple sclerosis.
    J Clin Invest. 2023 Sep 7:e162788. doi: 10.1172/JCI162788.
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    August 2023
  4. OWENS GP, Fellin TJ, Matschulat A, Salas V, et al
    Pathogenic myelin specific antibodies in multiple sclerosis target conformational proteolipid protein 1 anchored membrane domains.
    J Clin Invest. 2023 Aug 10:e162731. doi: 10.1172/JCI162731.
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    May 2023
  5. KERKERING J, Muinjonov B, Rosiewicz KS, Diecke S, et al
    iPSC-derived reactive astrocytes from patients with multiple-sclerosis protect cocultured neurons in inflammatory conditions.
    J Clin Invest. 2023 May 23:e164637. doi: 10.1172/JCI164637.
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    Clostridium epsilon toxin is excessive in multiple sclerosis and provokes multifocal lesions in mouse models.
    J Clin Invest. 2023;133:e169643.
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  7. MA Y, Sannino D, Linden JR, Haigh S, et al
    Epsilon toxin-producing Clostridium perfringens colonize the multiple sclerosis gut microbiome overcoming CNS immune privilege.
    J Clin Invest. 2023;133:e163239.
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    April 2023
  8. ANTEL JP, Kennedy TE, Kuhlmann T
    Seeking neuroprotection in multiple sclerosis: an ongoing challenge.
    J Clin Invest. 2023;133:e168595.
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  9. KAPELL H, Fazio L, Dyckow J, Schwarz S, et al
    Neuron-oligodendrocyte potassium shuttling at nodes of Ranvier protects against inflammatory demyelination.
    J Clin Invest. 2023;133:e164223.
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    October 2022
  10. ASASHIMA H, Axisa PP, Pham THG, Longbrake EE, et al
    Impaired TIGIT expression on B cells drives circulating follicular helper T cell expansion in multiple sclerosis.
    J Clin Invest. 2022;132.
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    September 2022
  11. HORWITZ RI, Hayes-Conroy A, Singer BH, Cullen MR, et al
    Falling down the biological rabbit hole: Epstein-Barr virus, biography, and multiple sclerosis.
    J Clin Invest. 2022;132.
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    May 2022
  12. FUJIWARA M, Raheja R, Garo LP, Ajay AK, et al
    microRNA-92a promotes CNS autoimmunity by modulating the regulatory and inflammatory T cell balance.
    J Clin Invest. 2022;132.
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  13. TYLER KL
    The enigmatic links between Epstein-Barr virus infection and multiple sclerosis.
    J Clin Invest. 2022;132.
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    July 2021
  14. GHEZZI L, Cantoni C, Pinget GV, Zhou Y, et al
    Targeting the gut to treat multiple sclerosis.
    J Clin Invest. 2021;131.
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    June 2021
  15. SINGH AK, Netea MG, Bishai WR
    BCG turns 100: its nontraditional uses against viruses, cancer, and immunologic diseases.
    J Clin Invest. 2021;131.
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    November 2020
  16. POMPURA SL, Wagner A, Kitz A, Laperche J, et al
    Oleic acid restores suppressive defects in tissue-resident FOXP3 regulatory T cells from patients with multiple sclerosis.
    J Clin Invest. 2020 Nov 10. pii: 138519. doi: 10.1172/JCI138519.
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    April 2020
  17. LI Z, Korhonen EA, Merlini A, Strauss J, et al
    Angiopoietin-2 blockade ameliorates autoimmune neuroinflammation by inhibiting leukocyte recruitment into the CNS.
    J Clin Invest. 2020;130:1977-1990.
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