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Multiple Sclerosis

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Articles published in
PLoS One
    January 2026
  1. CARDINI R, Gervasoni E, Germanotta M, Aprile IG, et al
    Consensus on recommended evaluation tools in multiple sclerosis (CORE-MS): A Delphi study protocol on balance and gait assessment.
    PLoS One. 2026;21:e0337440.
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  2. YANG B, Molton I, Humbert A, Baylor C, et al
    Environmental influences on community participation among people with multiple sclerosis: A mixed methods study.
    PLoS One. 2026;21:e0342678.
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  3. DENG Q, Bai Q, Yang Y, Tang W, et al
    A new mechanism regulating microglial NLRP3 inflammasome: FMR1 mediates NLRP3 mRNA stability.
    PLoS One. 2026;21:e0341867.
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  4. AKBARI H, Ragerdi-Kashani I, Rezaei-Yazdi F, Pasbakhsh P, et al
    Effect of transplanted oligodendrocyte precursor cells derived from inflammatory and non-inflammatory microenvironment on remyelination in a chronic cuprizone model.
    PLoS One. 2026;21:e0343039.
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  5. GIORDANO A, De Panfilis L, Zagarella RM, Di Domenico G, et al
    Communication competences of multiple sclerosis neurologists during advance care planning conversations: A multi-observer study.
    PLoS One. 2026;21:e0336183.
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    January 2025
  6. SIEBALD F, Grittner U, Otto C, Bereuter C, et al
    Ultrasound pupillometry for the detection of a relative afferent pupillary defect (RAPD): Systematic evaluation in patients with optic neuritis and comparison with infrared video pupillometry.
    PLoS One. 2025;20:e0315712.
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  7. VAN REENEN EC, van Nistelrooij IAM, Visser LH, de Beukelaar JWK, et al
    The liminal space between hope and grief: The phenomenon of uncertainty as experienced by people living with relapsing-remitting multiple sclerosis.
    PLoS One. 2025;20:e0315501.
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  8. JAALKHOROL M, Dashtseren A, Magnaibayar G, Bat-Orgil B, et al
    Factors associated with vitamin D levels in Mongolian patients with multiple sclerosis.
    PLoS One. 2025;20:e0317279.
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  9. COSTA V, Aluan K, Schiavetti I, Bason C, et al
    Study protocol: Exploratory trial of Forza, an osmotin-based nutraceutical as adjuvant for the treatment of progressive multiple sclerosis.
    PLoS One. 2025;20:e0311214.
    >> Share

  10. KHDAIR SI, Al-Khareisha L, Abusara OH, Hammad AM, et al
    HLA-class II genes association with multiple sclerosis: An immunogenetic prediction among multiple sclerosis Jordanian patients.
    PLoS One. 2025;20:e0318824.
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  11. DE DIOS PEREZ B, Booth V, das Nair R, Evangelou N, et al
    Vocational rehabilitation for people with multiple sclerosis in the national health service of the United Kingdom: A realist evaluation.
    PLoS One. 2025;20:e0319287.
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  12. RUSSO JS, Mahoney T, Kokorin K, Reynolds A, et al
    Towards developing brain-computer interfaces for people with Multiple Sclerosis.
    PLoS One. 2025;20:e0319811.
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  13. ETEMADIFAR M, Shoeib S, Salari M, Etemadifar M, et al
    Gynecologic health of women with multiple sclerosis: An overview on the current status and findings of Pap tests in a low-income setting.
    PLoS One. 2025;20:e0320069.
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  14. GOETTFRIED E, Barket R, Hershman R, Delazer M, et al
    Face exploration, emotion recognition, and emotional enhancement of memory in relapsing-remitting multiple sclerosis.
    PLoS One. 2025;20:e0319967.
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  15. SCHLAEGER S, Muhlau M, Gilbert G, Vavasour I, et al
    Sensitivity of multi-parametric quantitative magnetic resonance imaging for multiple sclerosis pathology.
    PLoS One. 2025;20:e0318415.
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  16. ZANGENEH Z, Rostamian M, Motamedi H, Alvandi A, et al
    The potential effectiveness of probiotics in reducing multiple sclerosis progression in preclinical and clinical studies: A worldwide systematic review and meta-analysis.
    PLoS One. 2025;20:e0319755.
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  17. OMER N, Wilczynski E, Zlotzover S, Helft C, et al
    Validation of a data-driven multicomponent T2 analysis for quantifying myelin content in the cuprizone mouse model of multiple sclerosis.
    PLoS One. 2025;20:e0323614.
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  18. YOUNG G, Nguyen VS, Howlett-Prieto Q, Abuaf AF, et al
    Validation of retroactively derived T1 relaxation values from 3D T1-weighted images with clinical and MRI measures of disability in multiple sclerosis.
    PLoS One. 2025;20:e0323898.
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  19. OZTURK HK, Slanar O, Michalickova D
    Safety and efficacy of antigen-specific therapeutic approaches for multiple sclerosis: Systematic review.
    PLoS One. 2025;20:e0320814.
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  20. DE DIOS PEREZ B, Kendrick D, das Nair R, Evangelou N, et al
    Optimising access to vocational rehabilitation through multiple sclerosis charities: Protocol for a feasibility randomised controlled trial.
    PLoS One. 2025;20:e0325570.
    >> Share

  21. GONG X, Xue X, Gao R, Feng S, et al
    Application of telemedicine in fatigue management for patients with multiple sclerosis: A scoping review.
    PLoS One. 2025;20:e0327563.
    >> Share

  22. MIRMOSAYYEB O, Vaheb S, Afshari-Safavi A, Shaygannejad A, et al
    Long-term effects of air pollution on the incidence and progression of multiple sclerosis: A population cohort study in Isfahan, Iran.
    PLoS One. 2025;20:e0327635.
    >> Share

  23. AL-EITAN L, Darabseh S
    VDR gene variants FokI and ApaI: Factors associated with susceptibility to multiple sclerosis.
    PLoS One. 2025;20:e0332473.
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  24. LI L, Olcer M, Wang Z, Song Y, et al
    IFN-beta therapy rescues dysregulated IFN-stimulated proteins, serum cytokines, and neurotrophic factors in multiple sclerosis: Multiplex analysis of short-term and long-term IFN responses.
    PLoS One. 2025;20:e0330867.
    >> Share

  25. AL-EITAN L, Ataa A
    Investigating genetic links of vitamin D metabolism pathway genes (CYP2R1, CYP27B1, CYP24A1, and DBP) in Multiple Sclerosis patients.
    PLoS One. 2025;20:e0333924.
    >> Share

  26. SOLARI A, De Panfilis L, Zagarella RM, Ghirotto L, et al
    Advance care planning in multiple sclerosis (ConCure-SM): A multicenter single-arm pilot and feasibility study.
    PLoS One. 2025;20:e0331220.
    >> Share

  27. SHEMIRANI F, Pingel WR, Titcomb TJ, Salari-Moghaddam A, et al
    Correction: The effect of dietary interventions on inflammatory biomarkers among people with multiple sclerosis: A protocol for systematic review and meta-analysis of randomized controlled trials.
    PLoS One. 2025;20:e0334893.
    >> Share

  28. LTEIF MR, Kalot J, Jaouni ME, Khoury SJ, et al
    E-health literacy levels of multiple sclerosis patients in Lebanon.
    PLoS One. 2025;20:e0335084.
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  29. JIANG L, Jin Y, Han Y, Fu J, et al
    TRIM37-mediated stabilization of PEX5 via monoubiquitination attenuates oxidative stress and demyelination in multiple sclerosis insights from EAE and LPC-induced experimental models.
    PLoS One. 2025;20:e0335198.
    >> Share

  30. FAHY A, Coote S, Maguire R
    Evaluation of MoveSmart MS - an online structured exercise, Social Cognitive Theory-based behavioural coaching and peer support programme - on anxiety in multiple sclerosis.
    PLoS One. 2025;20:e0336493.
    >> Share

  31. SURESHKUMAR A, Simpson R, Bayley M, Kastner M, et al
    The use of implementation strategies to promote the uptake of psychological therapies among people with multiple sclerosis: A scoping review protocol.
    PLoS One. 2025;20:e0337105.
    >> Share

  32. TABATABAEE S, Eissazade N, Mirzaasgari Z, Tabatabaee SM, et al
    Trans-orbital sonography of the optic nerve in multiple sclerosis.
    PLoS One. 2025;20:e0336564.
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  33. SALMAN F, Bergsland N, Dwyer MG, Reeves JA, et al
    Impact of processing and analysis methodology on thalamic susceptibility assessment in multiple sclerosis.
    PLoS One. 2025;20:e0332478.
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  34. KREITER D, Franken N, Bouweriks D, Knippenberg S, et al
    Spinal cord lesions in relapsing-remitting multiple sclerosis: Prognostic value of intrathecal production of immunoglobulins.
    PLoS One. 2025;20:e0337515.
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  35. VESTITO L, Schenone C, Casazza F, Modenesi R, et al
    Impact of anodal tDCS and virtual reality on cognitive dysfunction in patients with Multiple Sclerosis: Protocol of a double blind, randomized, prospective, controlled study.
    PLoS One. 2025;20:e0337405.
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  36. BUCHKA S, Havla J, On BI, Rehms R, et al
    Individual-level surrogacy of MRI lesions for disease severity in RRMS: Methods to quantify predictive power and their application to longitudinal data from recent trials.
    PLoS One. 2025;20:e0337893.
    >> Share

    January 2024
  37. TOLF A, Gauffin H, Burman J, Landtblom AM, et al
    Experiences of being treated with autologous haematopoietic stem cell transplantation for aggressive multiple sclerosis: A qualitative interview study.
    PLoS One. 2024;19:e0297573.
    >> Share

  38. SHEMIRANI F, Pingel WR, Titcomb TJ, Salari-Moghaddam A, et al
    The effect of dietary interventions on inflammatory biomarkers among people with multiple sclerosis: A protocol for systematic review and meta-analysis of randomized controlled trials.
    PLoS One. 2024;19:e0297510.
    >> Share

  39. DADVAR A, Jameie M, Azizmohammad Looha M, Parsaei M, et al
    Potential efficacy of caffeine ingestion on balance and mobility in patients with multiple sclerosis: Preliminary evidence from a single-arm pilot clinical trial.
    PLoS One. 2024;19:e0297235.
    >> Share

  40. JOZEF M, Locatelli I, Brecl Jakob G, Savsek L, et al
    Psychometric evaluation of the 5-item Medication Adherence Report Scale questionnaire in persons with multiple sclerosis.
    PLoS One. 2024;19:e0294116.
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  41. LIU Z, Fan T, Mo X, Kan J, et al
    Association between multiple sclerosis and cancer risk: A two-sample Mendelian randomization study.
    PLoS One. 2024;19:e0298271.
    >> Share

  42. CARATIS F, Opielka M, Hausmann M, Velasco-Estevez M, et al
    The proton-sensing receptors TDAG8 and GPR4 are differentially expressed in human and mouse oligodendrocytes: Exploring their role in neuroinflammation and multiple sclerosis.
    PLoS One. 2024;19:e0283060.
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  43. LEREIM RR, Nytrova P, Guldbrandsen A, Havrdova EK, et al
    Natalizumab promotes anti-inflammatory and repair effects in multiple sclerosis.
    PLoS One. 2024;19:e0300914.
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  44. BRNABIC AJM, Curtis SE, Johnston JA, Lo A, et al
    Incidence of type 2 diabetes, cardiovascular disease and chronic kidney disease in patients with multiple sclerosis initiating disease-modifying therapies: Retrospective cohort study using a frequentist model averaging statistical framework.
    PLoS One. 2024;19:e0300708.
    >> Share

  45. IMRAISH A, Abu Thiab T, Alsalem M, Dahbour S, et al
    The neuroprotective effect of human primary astrocytes in multiple sclerosis: In vitro model.
    PLoS One. 2024;19:e0300203.
    >> Share

  46. KAMPAITE A, Gustafsson R, York EN, Foley P, et al
    Brain connectivity changes underlying depression and fatigue in relapsing-remitting multiple sclerosis: A systematic review.
    PLoS One. 2024;19:e0299634.
    >> Share

  47. YAGHOOBPOOR S, Fathi M, Vakili K, Sayehmiri F, et al
    Insulin-like growth factor-1 (IGF-1) levels in multiple sclerosis patients: A systematic review and meta-analysis.
    PLoS One. 2024;19:e0297091.
    >> Share

  48. LOMER NB, Asalemi KA, Saberi A, Sarlak K, et al
    Predictors of multiple sclerosis progression: A systematic review of conventional magnetic resonance imaging studies.
    PLoS One. 2024;19:e0300415.
    >> Share

  49. HARRISON DM, Allette YM, Zeng Y, Cohen A, et al
    Meningeal contrast enhancement in multiple sclerosis: Assessment of field strength, acquisition delay, and clinical relevance.
    PLoS One. 2024;19:e0300298.
    >> Share

  50. BALDASSO BD, Raza SZ, Islam SS, Burry IB, et al
    Disrupted hemodynamic response within dorsolateral prefrontal cortex during cognitive tasks among people with multiple sclerosis-related fatigue.
    PLoS One. 2024;19:e0303211.
    >> Share

  51. STEFANOVIC M, Jovanovic I, Zivkovic M, Stankovic A, et al
    Pathway analysis of peripheral blood CD8+ T cell transcriptome shows differential regulation of sphingolipid signaling in multiple sclerosis and glioblastoma.
    PLoS One. 2024;19:e0305042.
    >> Share

  52. LI L, Zhang M, Gu M, Li J, et al
    The causal relationship between autoimmune diseases and age-related macular degeneration: A two-sample mendelian randomization study.
    PLoS One. 2024;19:e0303170.
    >> Share

  53. CAMPANIONI S, Veiga C, Prieto-Gonzalez JM, Gonzalez-Novoa JA, et al
    Explainable machine learning on baseline MRI predicts multiple sclerosis trajectory descriptors.
    PLoS One. 2024;19:e0306999.
    >> Share

  54. LI B, Zhang L, Li Q, Zhang J, et al
    Multiple sclerosis and abnormal spermatozoa: A bidirectional two-sample mendelian randomization study.
    PLoS One. 2024;19:e0308815.
    >> Share

  55. KAKUCS Z, Illes Z, Hayden Z, Berki T, et al
    Osteopontin predicts late-time salience network-related functional connectivity in multiple sclerosis.
    PLoS One. 2024;19:e0309563.
    >> Share

  56. SOKRATOUS D, Charalambous CC, Zamba-Papanicolaou E, Michailidou K, et al
    A 12-week in-phase bilateral upper limb exercise protocol promoted neuroplastic and clinical changes in people with relapsing remitting multiple sclerosis: A registered report randomized single-case concurrent multiple baseline study.
    PLoS One. 2024;19:e0299611.
    >> Share

  57. SABOYA-GALINDO P, Mejia-Salgado G, Cifuentes-Gonzalez C, Rodriguez-Rodriguez CA, et al
    Uveitis characteristics and multiple sclerosis phenotype of patients with multiple sclerosis-associated uveitis: A systematic review and meta-analysis.
    PLoS One. 2024;19:e0307455.
    >> Share

  58. TISELL A, Soderberg K, Link Y, Lundberg P, et al
    Diffuse white matter pathology in multiple sclerosis during treatment with dimethyl fumarate-An observational study of changes in normal-appearing white matter using proton magnetic resonance spectroscopy.
    PLoS One. 2024;19:e0309547.
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  59. FABER W, Stillebroer AB
    Addressing bladder and bowel challenges in dutch multiple sclerosis patients: Symptom prevalence and patient referral pathways.
    PLoS One. 2024;19:e0310691.
    >> Share

  60. NAFARI A, Vaheb S, Afshari-Safavi A, Ravankhah Z, et al
    Cancer and mortality risks among people with multiple sclerosis: A population-based study in Isfahan, Iran.
    PLoS One. 2024;19:e0312707.
    >> Share

  61. IAQUINTO S, Ineichen BV, Salmen A, Kuhle J, et al
    Factors associated with low health-related quality of life in persons with multiple sclerosis: A quantile-based segmentation approach.
    PLoS One. 2024;19:e0312486.
    >> Share

  62. MARIC GD, Pekmezovic TD, Tamas OS, Veselinovic ND, et al
    Investigation of differences between chronological and vascular age in persons with multiple sclerosis.
    PLoS One. 2024;19:e0311117.
    >> Share

  63. SANTISTEBAN L, Teremetz M, Irazusta J, Lindberg PG, et al
    Correction: Outcome measures used in trials on gait rehabilitation in multiple sclerosis: A systematic literature review.
    PLoS One. 2024;19:e0314427.
    >> Share

  64. NAJMI EA, Mirzaasgari Z, Motamed MR, Aslani A, et al
    Carotid intima-media thickness and risk of atherosclerosis in multiple sclerosis: A cross-sectional study.
    PLoS One. 2024;19:e0314031.
    >> Share

  65. ZURRER WE, Cannon AE, Ewing E, Bruschweiler D, et al
    STEED: A data mining tool for automated extraction of experimental parameters and risk of bias items from in vivo publications.
    PLoS One. 2024;19:e0311358.
    >> Share

  66. MIRMOSAYYEB O, Yazdan Panah M, Mokary Y, Mohammadi M, et al
    Neuroimaging markers and disability scales in multiple sclerosis: A systematic review and meta-analysis.
    PLoS One. 2024;19:e0312421.
    >> Share

  67. RASOULI S, Dakkali MS, Ghazvini A, Azarbad R, et al
    Predictive model for converting optic neuritis to multiple sclerosis; decision tree in focus.
    PLoS One. 2024;19:e0309702.
    >> Share

  68. SHRIWASH N, Aiman A, Singh P, Basir SF, et al
    Understanding the role of potential biomarkers in attenuating multiple sclerosis progression via multiomics and network-based approach.
    PLoS One. 2024;19:e0314428.
    >> Share

  69. KOOSHKI A, Farmani R, Amirabadizadeh A, Mehrpour O, et al
    Essential and toxic metal concentrations in biological samples of multiple sclerosis patients: A systematic review and meta-analysis.
    PLoS One. 2024;19:e0313851.
    >> Share

  70. BIGDELI A, Ghaderi-Zefrehei M, Lesch BJ, Behmanesh M, et al
    Bioinformatics analysis of myelin-microbe interactions suggests multiple types of molecular mimicry in the pathogenesis of multiple sclerosis.
    PLoS One. 2024;19:e0308817.
    >> Share

    January 2023
  71. SOKRATOUS D, Charalambous CC, Papanicolaou EZ, Michailidou K, et al
    Investigation of in-phase bilateral exercise effects on corticospinal plasticity in relapsing remitting multiple sclerosis: A registered report single-case concurrent multiple baseline design across five subjects.
    PLoS One. 2023;18:e0272114.
    >> Share

  72. ERSOY T, Hocaoglu E
    A 3-DoF robotic platform for the rehabilitation and assessment of reaction time and balance skills of MS patients.
    PLoS One. 2023;18:e0280505.
    >> Share

  73. SEDIGHI B, Haghdoost A, Jangipour Afshar P, Abna Z, et al
    Multiple sclerosis and COVID-19: A retrospective study in Iran.
    PLoS One. 2023;18:e0283538.
    >> Share

  74. LAICHINGER K, Bombach P, Dunschede J, Ruschil C, et al
    No evidence of oligoclonal bands, intrathecal immunoglobulin synthesis and B cell recruitment in acute ischemic stroke.
    PLoS One. 2023;18:e0283476.
    >> Share

  75. ZAFEIRI L, Akerfeldt T, Tolf A, Carlson K, et al
    Anti-Mullerian hormone and pregnancy after autologous hematopoietic stem cell transplantation for multiple sclerosis.
    PLoS One. 2023;18:e0284288.
    >> Share

  76. BENINI S, Pellegrini E, Descovich C, Lugaresi A, et al
    Burden and resources in caregivers of people with multiple sclerosis: A qualitative study.
    PLoS One. 2023;18:e0265297.
    >> Share

  77. STAHL D, Friberg E
    Formal help for persons with multiple sclerosis-Background factors associated with usage of personal assistance and home help in Sweden.
    PLoS One. 2023;18:e0286010.
    >> Share

  78. EVEREST E, Uygunoglu U, Tutuncu M, Bulbul A, et al
    Prospective outcome analysis of multiple sclerosis cases reveals candidate prognostic cerebrospinal fluid markers.
    PLoS One. 2023;18:e0287463.
    >> Share

  79. GOODIN DS, Khankhanian P, Gourraud PA, Vince N, et al
    Multiple sclerosis: Exploring the limits and implications of genetic and environmental susceptibility.
    PLoS One. 2023;18:e0285599.
    >> Share

  80. ESCHWEILER M, McCrum C, Giannouli E
    A registered report of a crossover study on the effects of face masks on walking adaptability in people with Parkinson's disease and multiple sclerosis.
    PLoS One. 2023;18:e0286402.
    >> Share

  81. VILADES E, Cordon B, Perez-Velilla J, Orduna E, et al
    Evaluation of multiple sclerosis severity using a new OCT tool.
    PLoS One. 2023;18:e0288581.
    >> Share

  82. NAISBY J, Wilson-Menzfeld G, Baker K, Morris R, et al
    Yoga and Multiple Sclerosis: Maintaining engagement in physical activity.
    PLoS One. 2023;18:e0288319.
    >> Share

  83. FRAGKIADAKI E, Cotterill N, Rice C, Smith JA, et al
    Evaluation of the feasibility and acceptability of an integrative group psychological intervention for people with Multiple Sclerosis: A study protocol.
    PLoS One. 2023;18:e0288295.
    >> Share

  84. RAZIA R, Majeed F, Amin R, Mukhtar S, et al
    Predictive value of alpha-synuclein expression in peripheral blood of multiple sclerosis patients: A two-dimensional assessment of a selected biomarker.
    PLoS One. 2023;18:e0285022.
    >> Share

  85. MACHADO A, Azad A, Pettersson E, Hillert J, et al
    Gender differences in earnings among people with multiple sclerosis and associations with type of occupation and family composition: A population-based study with matched references.
    PLoS One. 2023;18:e0288998.
    >> Share

  86. MEIJBOOM R, York EN, Kampaite A, Harris MA, et al
    Patterns of brain atrophy in recently-diagnosed relapsing-remitting multiple sclerosis.
    PLoS One. 2023;18:e0288967.
    >> Share

  87. HERNANDEZ M, Ramon-Julvez U, Vilades E, Cordon B, et al
    Explainable artificial intelligence toward usable and trustworthy computer-aided diagnosis of multiple sclerosis from Optical Coherence Tomography.
    PLoS One. 2023;18:e0289495.
    >> Share

  88. HARRIS VK, Wollowitz J, Greenwald J, Carlson AL, et al
    Mesenchymal stem cell-neural progenitors are enriched in cell signaling molecules implicated in their therapeutic effect in multiple sclerosis.
    PLoS One. 2023;18:e0290069.
    >> Share

  89. POLICK CS, Ploutz-Snyder R, Braley TJ, Connell CM, et al
    Fatigue, pain interference, and psychiatric morbidity in multiple sclerosis: The role of childhood stress.
    PLoS One. 2023;18:e0292233.
    >> Share

  90. WOCHATZ M, Schraplau A, Engel T, Zecher MM, et al
    Correction: Application of eccentric training in various clinical populations: Protocol for a multi-centered pilot and feasibility study in people with low back pain and people with multiple sclerosis.
    PLoS One. 2023;18:e0293225.
    >> Share

  91. O'MALLEY N, Coote S, Staunton FM, O'Connor E, et al
    A core outcome set for evaluating the effectiveness of mixed-diagnosis falls prevention interventions for people with Multiple Sclerosis, Parkinson's Disease and stroke.
    PLoS One. 2023;18:e0294193.
    >> Share

  92. KRAKENES T, Wergeland S, Al-Sharabi N, Mohamed-Ahmed S, et al
    The neuroprotective potential of mesenchymal stem cells from bone marrow and human exfoliated deciduous teeth in a murine model of demyelination.
    PLoS One. 2023;18:e0293908.
    >> Share

  93. WILF-YARKONI A, Feldmann K, Rubarth K, Dorsch EM, et al
    Effectiveness of oral prednisone tapering following intravenous methylprednisolone for acute optic neuritis in multiple sclerosis.
    PLoS One. 2023;18:e0288366.
    >> Share


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