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Articles published in
Proc Natl Acad Sci U S A
    March 2021
  1. MULLER K, Honcharova-Biletska H, Koppe C, Egger M, et al
    JNK signaling prevents biliary cyst formation through a CASPASE-8-dependent function of RIPK1 during aging.
    Proc Natl Acad Sci U S A. 2021;118.
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  2. PICCOLO P, Ferriero R, Barbato A, Attanasio S, et al
    Up-regulation of miR-34b/c by JNK and FOXO3 protects from liver fibrosis.
    Proc Natl Acad Sci U S A. 2021;118.
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    January 2021
  3. CHIBAYA L, Karim B, Zhang H, Jones SN, et al
    Mdm2 phosphorylation by Akt regulates the p53 response to oxidative stress to promote cell proliferation and tumorigenesis.
    Proc Natl Acad Sci U S A. 2021;118.
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  4. WANG Q, Kim SY, Matsushita H, Wang Z, et al
    Oral administration of PEGylated TLR7 ligand ameliorates alcohol-associated liver disease via the induction of IL-22.
    Proc Natl Acad Sci U S A. 2021;118.
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    December 2020
  5. CONCILLI M, Petruzzelli R, Parisi S, Catalano F, et al
    Pharmacoproteomics pinpoints HSP70 interaction for correction of the most frequent Wilson disease-causing mutant of ATP7B.
    Proc Natl Acad Sci U S A. 2020;117:32453-32463.
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  6. BAILEY AL, Kang LI, de Assis Barros D'Elia Zanella LGF, Silveira CGT, et al
    Consumptive coagulopathy of severe yellow fever occurs independently of hepatocellular tropism and massive hepatic injury.
    Proc Natl Acad Sci U S A. 2020;117:32648-32656.
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  7. CHEN W, Li X, Liu C, He J, et al
    beta-Cyclodextrin modified Pt(II) metallacycle-based supramolecular hyperbranched polymer assemblies for DOX delivery to liver cancer cells.
    Proc Natl Acad Sci U S A. 2020;117:30942-30948.
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  8. YUEH MF, He F, Chen C, Vu C, et al
    Triclosan leads to dysregulation of the metabolic regulator FGF21 exacerbating high fat diet-induced nonalcoholic fatty liver disease.
    Proc Natl Acad Sci U S A. 2020;117:31259-31266.
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    November 2020
  9. FLORES-COSTA R, Duran-Guell M, Casulleras M, Lopez-Vicario C, et al
    Stimulation of soluble guanylate cyclase exerts antiinflammatory actions in the liver through a VASP/NF-kappaB/NLRP3 inflammasome circuit.
    Proc Natl Acad Sci U S A. 2020;117:28263-28274.
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  10. LIU S, Luttrell LM, Premont RT, Rockey DC, et al
    Reply to Schierwagen et al.: beta-Arrestins in liver disease.
    Proc Natl Acad Sci U S A. 2020;117:27085-27086.
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  11. SCHIERWAGEN R, Dietrich P, Klein S, Uschner FE, et al
    beta-Arrestin2 is increased in liver fibrosis in humans and rodents.
    Proc Natl Acad Sci U S A. 2020;117:27082-27084.
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    October 2020
  12. WANG C, Tang H, Geng A, Dai B, et al
    Rational combination therapy for hepatocellular carcinoma with PARP1 and DNA-PK inhibitors.
    Proc Natl Acad Sci U S A. 2020;117:26356-26365.
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    September 2020
  13. FISHBEIN A, Wang W, Yang H, Yang J, et al
    Resolution of eicosanoid/cytokine storm prevents carcinogen and inflammation-initiated hepatocellular cancer progression.
    Proc Natl Acad Sci U S A. 2020;117:21576-21587.
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    August 2020
  14. ITATANI Y, Yamamoto T, Zhong C, Molinolo AA, et al
    Suppressing neutrophil-dependent angiogenesis abrogates resistance to anti-VEGF antibody in a genetic model of colorectal cancer.
    Proc Natl Acad Sci U S A. 2020 Aug 19. pii: 2008112117.
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    July 2020
  15. WU H, Reizel T, Wang YJ, Lapiro JL, et al
    A negative reciprocal regulatory axis between cyclin D1 and HNF4alpha modulates cell cycle progression and metabolism in the liver.
    Proc Natl Acad Sci U S A. 2020;117:17177-17186.
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    June 2020
  16. TAN S, Zhao J, Sun Z, Cao S, et al
    Hepatocyte-specific TAK1 deficiency drives RIPK1 kinase-dependent inflammation to promote liver fibrosis and hepatocellular carcinoma.
    Proc Natl Acad Sci U S A. 2020;117:14231-14242.
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    May 2020
  17. LIU S, Luttrell LM, Premont RT, Rockey DC, et al
    beta-Arrestin2 is a critical component of the GPCR-eNOS signalosome.
    Proc Natl Acad Sci U S A. 2020;117:11483-11492.
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  18. LUTHER J, Khan S, Gala MK, Kedrin D, et al
    Hepatic gap junctions amplify alcohol liver injury by propagating cGAS-mediated IRF3 activation.
    Proc Natl Acad Sci U S A. 2020;117:11667-11673.
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  19. NILSSON A, Haanstra JR, Engqvist M, Gerding A, et al
    Quantitative analysis of amino acid metabolism in liver cancer links glutamate excretion to nucleotide synthesis.
    Proc Natl Acad Sci U S A. 2020;117:10294-10304.
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    April 2020
  20. NOZAKI Y, Petersen MC, Zhang D, Vatner DF, et al
    Metabolic control analysis of hepatic glycogen synthesis in vivo.
    Proc Natl Acad Sci U S A. 2020;117:8166-8176.
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    March 2020
  21. LUUKKONEN PK, Dufour S, Lyu K, Zhang XM, et al
    Effect of a ketogenic diet on hepatic steatosis and hepatic mitochondrial metabolism in nonalcoholic fatty liver disease.
    Proc Natl Acad Sci U S A. 2020;117:7347-7354.
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  22. LIU M, Yan Q, Sun Y, Nam Y, et al
    A hepatocyte differentiation model reveals two subtypes of liver cancer with different oncofetal properties and therapeutic targets.
    Proc Natl Acad Sci U S A. 2020;117:6103-6113.
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  23. JIANG H, Cao HJ, Ma N, Bao WD, et al
    Chromatin remodeling factor ARID2 suppresses hepatocellular carcinoma metastasis via DNMT1-Snail axis.
    Proc Natl Acad Sci U S A. 2020;117:4770-4780.
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    January 2020
  24. WOOTON-KEE CR, Robertson M, Zhou Y, Dong B, et al
    Metabolic dysregulation in the Atp7b (-/-) Wilson's disease mouse model.
    Proc Natl Acad Sci U S A. 2020;117:2076-2083.
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  25. WINKLER I, Bitter C, Winkler S, Weichenhan D, et al
    Identification of Ppargamma-modulated miRNA hubs that target the fibrotic tumor microenvironment.
    Proc Natl Acad Sci U S A. 2020;117:454-463.
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    October 2019
  26. TRUONG B, Allegri G, Liu XB, Burke KE, et al
    Lipid nanoparticle-targeted mRNA therapy as a treatment for the inherited metabolic liver disorder arginase deficiency.
    Proc Natl Acad Sci U S A. 2019;116:21150-21159.
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    September 2019
  27. LIU K, Theusch E, Zhou Y, Ashuach T, et al
    GeneFishing to reconstruct context specific portraits of biological processes.
    Proc Natl Acad Sci U S A. 2019;116:18943-18950.
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    July 2019
  28. KINGSTON BR, Syed AM, Ngai J, Sindhwani S, et al
    Assessing micrometastases as a target for nanoparticles using 3D microscopy and machine learning.
    Proc Natl Acad Sci U S A. 2019;116:14937-14946.
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  29. WANG L, Mazagova M, Pan C, Yang S, et al
    YIPF6 controls sorting of FGF21 into COPII vesicles and promotes obesity.
    Proc Natl Acad Sci U S A. 2019 Jul 9. pii: 1904360116.
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  30. HUA G, Zein N, Paulen L, Chambon P, et al
    The glucocorticoid receptor agonistic modulators CpdX and CpdX-D3 do not generate the debilitating effects of synthetic glucocorticoids.
    Proc Natl Acad Sci U S A. 2019;116:14200-14209.
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  31. TORRES C, Mancinelli G, Cordoba-Chacon J, Viswakarma N, et al
    p110gamma deficiency protects against pancreatic carcinogenesis yet predisposes to diet-induced hepatotoxicity.
    Proc Natl Acad Sci U S A. 2019 Jul 2. pii: 1813012116.
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  32. MIYAUCHI T, Uchida Y, Kadono K, Hirao H, et al
    Up-regulation of FOXO1 and reduced inflammation by beta-hydroxybutyric acid are essential diet restriction benefits against liver injury.
    Proc Natl Acad Sci U S A. 2019;116:13533-13542.
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    June 2019
  33. AMOASII L, Sanchez-Ortiz E, Fujikawa T, Elmquist JK, et al
    NURR1 activation in skeletal muscle controls systemic energy homeostasis.
    Proc Natl Acad Sci U S A. 2019;116:11299-11308.
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  34. MCLOUGHLIN MR, Orlicky DJ, Prigge JR, Krishna P, et al
    TrxR1, Gsr, and oxidative stress determine hepatocellular carcinoma malignancy.
    Proc Natl Acad Sci U S A. 2019;116:11408-11417.
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    May 2019
  35. BASURAY S, Wang Y, Smagris E, Cohen JC, et al
    Accumulation of PNPLA3 on lipid droplets is the basis of associated hepatic steatosis.
    Proc Natl Acad Sci U S A. 2019;116:9521-9526.
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    April 2019
  36. PARK MJ, D'Alecy LG, Anderson MA, Basrur V, et al
    Constitutive release of CPS1 in bile and its role as a protective cytokine during acute liver injury.
    Proc Natl Acad Sci U S A. 2019;116:9125-9134.
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    March 2019
  37. WANG Y, Liang H, Jin F, Yan X, et al
    Injured liver-released miRNA-122 elicits acute pulmonary inflammation via activating alveolar macrophage TLR7 signaling pathway.
    Proc Natl Acad Sci U S A. 2019;116:6162-6171.
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  38. BESSE-PATIN A, Jeromson S, Levesque-Damphousse P, Secco B, et al
    PGC1A regulates the IRS1:IRS2 ratio during fasting to influence hepatic metabolism downstream of insulin.
    Proc Natl Acad Sci U S A. 2019;116:4285-4290.
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    January 2019
  39. CORDERO-HERRERA I, Kozyra M, Zhuge Z, McCann Haworth S, et al
    AMP-activated protein kinase activation and NADPH oxidase inhibition by inorganic nitrate and nitrite prevent liver steatosis.
    Proc Natl Acad Sci U S A. 2019;116:217-226.
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    December 2018
  40. FENG Z, Zou X, Chen Y, Wang H, et al
    Modulation of HIF-2alpha PAS-B domain contributes to physiological responses.
    Proc Natl Acad Sci U S A. 2018;115:13240-13245.
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  41. BIDKHORI G, Benfeitas R, Klevstig M, Zhang C, et al
    Metabolic network-based stratification of hepatocellular carcinoma reveals three distinct tumor subtypes.
    Proc Natl Acad Sci U S A. 2018;115:E11874-E11883.
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    November 2018
  42. JIANG P, Sun K, Tong YK, Cheng SH, et al
    Preferred end coordinates and somatic variants as signatures of circulating tumor DNA associated with hepatocellular carcinoma.
    Proc Natl Acad Sci U S A. 2018;115:E10925-E10933.
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    October 2018
  43. KODAMA T, Yi J, Newberg JY, Tien JC, et al
    Molecular profiling of nonalcoholic fatty liver disease-associated hepatocellular carcinoma using SB transposon mutagenesis.
    Proc Natl Acad Sci U S A. 2018;115:E10417-E10426.
    >> Share

  44. DOW M, Pyke RM, Tsui BY, Alexandrov LB, et al
    Integrative genomic analysis of mouse and human hepatocellular carcinoma.
    Proc Natl Acad Sci U S A. 2018;115:E9879-E9888.
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  45. WANG R, Li Y, Tsung A, Huang H, et al
    iNOS promotes CD24(+)CD133(+) liver cancer stem cell phenotype through a TACE/ADAM17-dependent Notch signaling pathway.
    Proc Natl Acad Sci U S A. 2018 Oct 8. pii: 1722100115.
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  46. HUANG Z, Zhang M, Plec AA, Estill SJ, et al
    ACSS2 promotes systemic fat storage and utilization through selective regulation of genes involved in lipid metabolism.
    Proc Natl Acad Sci U S A. 2018;115:E9499-E9506.
    >> Share

    September 2018
  47. SONNTAG R, Giebeler N, Nevzorova YA, Bangen JM, et al
    Cyclin E1 and cyclin-dependent kinase 2 are critical for initiation, but not for progression of hepatocellular carcinoma.
    Proc Natl Acad Sci U S A. 2018;115:9282-9287.
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    June 2018
  48. DAI J, Liang K, Zhao S, Jia W, et al
    Chemoproteomics reveals baicalin activates hepatic CPT1 to ameliorate diet-induced obesity and hepatic steatosis.
    Proc Natl Acad Sci U S A. 2018 Jun 11. pii: 1801745115.
    >> Share

    May 2018
  49. REGNAULT C, Usal M, Veyrenc S, Couturier K, et al
    Unexpected metabolic disorders induced by endocrine disruptors in Xenopus tropicalis provide new lead for understanding amphibian decline.
    Proc Natl Acad Sci U S A. 2018;115:E4416-E4425.
    >> Share

    April 2018
  50. BUNG N, Roy A, Chen B, Das D, et al
    Human hydroxymethylbilane synthase: Molecular dynamics of the pyrrole chain elongation identifies step-specific residues that cause AIP.
    Proc Natl Acad Sci U S A. 2018;115:E4071-E4080.
    >> Share

  51. QIN XY, Suzuki H, Honda M, Okada H, et al
    Prevention of hepatocellular carcinoma by targeting MYCN-positive liver cancer stem cells with acyclic retinoid.
    Proc Natl Acad Sci U S A. 2018 Apr 23. pii: 1802279115.
    >> Share

  52. BUGIDE S, Green MR, Wajapeyee N
    Inhibition of Enhancer of zeste homolog 2 (EZH2) induces natural killer cell-mediated eradication of hepatocellular carcinoma cells.
    Proc Natl Acad Sci U S A. 2018;115:E3509-E3518.
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    March 2018
  53. LANASPA MA, Kuwabara M, Andres-Hernando A, Li N, et al
    High salt intake causes leptin resistance and obesity in mice by stimulating endogenous fructose production and metabolism.
    Proc Natl Acad Sci U S A. 2018 Mar 5. pii: 1713837115.
    >> Share

    January 2018
  54. GENG Y, Michowski W, Chick JM, Wang YE, et al
    Kinase-independent function of E-type cyclins in liver cancer.
    Proc Natl Acad Sci U S A. 2018;115:1015-1020.
    >> Share

    December 2017
  55. HE X, Sun Y, Lei N, Fan X, et al
    MicroRNA-351 promotes schistosomiasis-induced hepatic fibrosis by targeting the vitamin D receptor.
    Proc Natl Acad Sci U S A. 2017 Dec 18. pii: 1715965115.
    >> Share

    November 2017
  56. YAO K, Peng C, Zhang Y, Zykova TA, et al
    RSK2 phosphorylates T-bet to attenuate colon cancer metastasis and growth.
    Proc Natl Acad Sci U S A. 2017 Nov 13. pii: 201710756.
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    March 2017
  57. MESCHIA JF
    Alpha-1 antitrypsin dysfunction and large artery stroke.
    Proc Natl Acad Sci U S A. 2017 Mar 27. pii: 201702751.
    >> Share

    October 2016
  58. WOZNIAK AL, Long A, Jones-Jamtgaard KN, Weinman SA, et al
    Hepatitis C virus promotes virion secretion through cleavage of the Rab7 adaptor protein RILP.
    Proc Natl Acad Sci U S A. 2016 Oct 17. pii: 201607277.
    >> Share

  59. ZHANG Z, Turer E, Li X, Zhan X, et al
    Insulin resistance and diabetes caused by genetic or diet-induced KBTBD2 deficiency in mice.
    Proc Natl Acad Sci U S A. 2016 Oct 5. pii: 201614467.
    >> Share


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