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Articles published in
Proc Natl Acad Sci U S A
    October 2026
  1. WU H, Shen X, Zhao T, Zhang H, et al
    Mechanotherapy enhances nanodrug uptake by overcoming the actin cytoskeleton damping effect.
    Proc Natl Acad Sci U S A. 2026;123:e2600686123.
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  2. KE M, Kim JW, Xu M, Wang J, et al
    Desulfinylation of the deubiquitinase USP7 by SRXN1 attenuates oxidative acute liver injury.
    Proc Natl Acad Sci U S A. 2026;123:e2620180123.
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  3. YU L, Ajiro M, Majerciak V, Lobanov A, et al
    SRSF3 plays a key role in liver cancer sex disparity by facilitating hepatocyte expression of ERalpha and FOXA.
    Proc Natl Acad Sci U S A. 2026;123:e2536317123.
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  4. NUOVO GJ, Heineman TC, Tili E, Croce CM, et al
    MicroRNA-driven regulation of immunosuppressive microenvironment in hepatocellular carcinoma.
    Proc Natl Acad Sci U S A. 2026;123:e2618249123.
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    September 2026
  5. NEMATI H, Suijkerbuijk SJE, de Graaf J
    Cell competition driven by secreted ligands: Modeling liver metastasis of colorectal cancer.
    Proc Natl Acad Sci U S A. 2026;123:e2531078123.
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    August 2026
  6. ZHANG D, Liu X, Ma D, Liao L, et al
    Macrophages diverge into profibrotic SAMs and proresolving ReM2 cells to regulate liver fibrosis.
    Proc Natl Acad Sci U S A. 2026;123:e2611441123.
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  7. MU J, Dong J, Chen J, Sima P, et al
    CXCR4-targeted dual softener for inducing senescence therapy in hepatic fibrosis.
    Proc Natl Acad Sci U S A. 2026;123:e2600215123.
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  8. LU Y, Gan L, Ru W, Guo Y, et al
    Co-phase separation of KRI1 and NPM1 sustains nucleolar integrity and ribosome biogenesis to fuel liver cancer progression.
    Proc Natl Acad Sci U S A. 2026;123:e2535921123.
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    July 2026
  9. JOHANNS M, Berthier A, Vandel J, Courquet S, et al
    The circadian clock controls hepatic stellate cell activation via a BMAL1/CK1epsilon/REV-ERBalpha/transgelin signaling pathway.
    Proc Natl Acad Sci U S A. 2026;123:e2611767123.
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  10. ZHANG S, Wang H, Cho Y, Rocha HL, et al
    Quantitative calibration of a spatial QSP model identifies fibroblast impact on HCC immunotherapy.
    Proc Natl Acad Sci U S A. 2026;123:e2525799123.
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    June 2026
  11. KLUIVER TA, Nordin A, Lu Y, Guo X, et al
    Differential Wnt/beta-catenin signaling via TCF7L2/LEF1 binding specificity shapes cellular and tumor phenotypes.
    Proc Natl Acad Sci U S A. 2026;123:e2528450123.
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  12. SU Q, Yang Y, Ren J, Zhang Y, et al
    RNF126 is a peroxisomal fate switch enabling redifferentiation therapy in hepatocellular carcinoma.
    Proc Natl Acad Sci U S A. 2026;123:e2535777123.
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  13. HUANG X, Hao J, Wang S, Deng B, et al
    mRNA-laden LNP-enabled in situ CAR-macrophage alleviates liver fibrosis via inhibiting activated HSCs and modulating the immune microenvironment.
    Proc Natl Acad Sci U S A. 2026;123:e2534673123.
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    May 2026
  14. CHEN L, Wang D, Qin W, Wang G, et al
    Mitochondrial fusion heterogeneity drives bidirectional tumor phenotypic transition in combined hepatocellular-cholangiocarcinoma.
    Proc Natl Acad Sci U S A. 2026;123:e2521310123.
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    April 2026
  15. OYABU M, Sakaue M, Kubo A, Yoshioka K, et al
    Loss of FoxO in skeletal muscle leads to disrupted muscle metabolism and exacerbates starvation-induced hepatic steatosis.
    Proc Natl Acad Sci U S A. 2026;123:e2600036123.
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  16. ZENG W, Liu CC, Li S, Zhou Y, et al
    Toward the simultaneous detection of multiple diseases with a highly cost-effective cell-free DNA methylome test.
    Proc Natl Acad Sci U S A. 2026;123:e2518347123.
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    February 2026
  17. QIN XY, Xu Y, Mishra H, Shirakami Y, et al
    Oncogenic function and transcriptional dynamics of MYCN in liver tumorigenesis.
    Proc Natl Acad Sci U S A. 2026;123:e2521923123.
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  18. HANNA BS, Langston PK, Marin-Rodero M, Ramirez RN, et al
    Regulatory T cells safeguard liver health during metabolic-associated steatohepatitis.
    Proc Natl Acad Sci U S A. 2026;123:e2536314123.
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  19. ZHANG L, Ren C, He M, Chen X, et al
    Mitochondrial transfer in the HSC-HCC-macrophage network shapes hepatocellular carcinoma progression.
    Proc Natl Acad Sci U S A. 2026;123:e2512592123.
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    January 2026
  20. LI D, Loneker AE, Safraou Y, Ford J, et al
    Cholesterol-containing lipid crystals can directly stiffen the rat steatotic liver before fibrosis.
    Proc Natl Acad Sci U S A. 2026;123:e2518060123.
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    December 2025
  21. QIN Q, Chen W, King CD, Kumar SP, et al
    Identification of an IRF-ZBP1-caspase-8-NINJ1 axis in driving PANoptosis and pathology during alcohol-associated liver disease.
    Proc Natl Acad Sci U S A. 2025;122:e2525296122.
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  22. ANGELES-SOLANO M, Tabashsum Z, Liu JD, Lifschin ZJ, et al
    Antibiotics accumulate in Klebsiella pneumoniae liver abscesses but fail to eliminate antibiotic-tolerant populations.
    Proc Natl Acad Sci U S A. 2025;122:e2524436122.
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    November 2025
  23. WORMSER L, Fritz V, Kappelmann-Fenzl M, Rachinger N, et al
    The liver talks back: NPY orchestrates attraction of cancer cells and CHK2-dependent clonogenicity in the metastatic niche.
    Proc Natl Acad Sci U S A. 2025;122:e2518418122.
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  24. ALDOBIYAN I, Elliston ELK, Heyer-Chauhan N, Arold ST, et al
    The mechanism of pathogenic alpha(1)-antitrypsin aggregation in the human liver.
    Proc Natl Acad Sci U S A. 2025;122:e2507535122.
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  25. CISOWSKI J, El Zowalaty AE, Sayin SI, Czarnota P, et al
    BRAF inhibition increases TGFbeta2 production and stimulates metastasis in mice with endogenous BRAF(V600E)-induced hepatocellular carcinoma.
    Proc Natl Acad Sci U S A. 2025;122:e2503044122.
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    October 2025
  26. GU L, Du Y, Nazmul Hasan M, Clayton YD, et al
    Adipose cullin 3 mediates the antiobesity effect of pan neddylation inhibitors.
    Proc Natl Acad Sci U S A. 2025;122:e2515947122.
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    September 2025
  27. YUAN Y, Niu Y, Huang Z, Shi Y, et al
    USP14-mediated metabolic competition impairs CD8+ T cell immunosurveillance in hepatocellular carcinoma.
    Proc Natl Acad Sci U S A. 2025;122:e2510576122.
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    August 2025
  28. CHEN P, Geng H, Ma B, Zhang Y, et al
    Integrating spatial omics and single-cell mass spectrometry imaging reveals tumor-host metabolic interplay in hepatocellular carcinoma.
    Proc Natl Acad Sci U S A. 2025;122:e2505789122.
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    July 2025
  29. WU J, Gao M, Wu X, Liu Y, et al
    PI(4)P recruits CIDE proteins to promote the formation of unilocular lipid droplets during adipogenesis and hepatic steatosis.
    Proc Natl Acad Sci U S A. 2025;122:e2504219122.
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    June 2025
  30. OZAKI MK, Zhang Y, Bartlett AQ, de Wilde E, et al
    Reproductive state controls transcription in the murine liver, with implications for breast cancer liver metastasis.
    Proc Natl Acad Sci U S A. 2025;122:e2420174122.
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    May 2025
  31. ZHANG Y, Zuo A, Ba Y, Liu S, et al
    Cancer-associated fibroblast-derived SEMA3C facilitates colorectal cancer liver metastasis via NRP2-mediated MAPK activation.
    Proc Natl Acad Sci U S A. 2025;122:e2423077122.
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  32. SAKUMA I, Gaspar RC, Nasiri AR, Dufour S, et al
    Liver lipid droplet cholesterol content is a key determinant of metabolic dysfunction-associated steatohepatitis.
    Proc Natl Acad Sci U S A. 2025;122:e2502978122.
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    February 2025
  33. QIAN X, Zhou Q, Ouyang Y, Wu X, et al
    Transferrin promotes fatty acid oxidation and liver tumor growth through PHD2-mediated PPARalpha hydroxylation in an iron-dependent manner.
    Proc Natl Acad Sci U S A. 2025;122:e2412473122.
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    January 2025
  34. SUN L, Hu P, Yang H, Ren J, et al
    ADARp110 promotes hepatocellular carcinoma progression via stabilization of CD24 mRNA.
    Proc Natl Acad Sci U S A. 2025;122:e2409724122.
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  35. XU X, Penjweini R, Szekvolgyi L, Karanyi Z, et al
    Endonuclease G promotes hepatic mitochondrial respiration by selectively increasing mitochondrial tRNA(Thr) production.
    Proc Natl Acad Sci U S A. 2025;122:e2411298122.
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  36. WANG J, Liao L, Miao B, Yang B, et al
    Deciphering the role of the MALT1-RC3H1 axis in regulating GPX4 protein stability.
    Proc Natl Acad Sci U S A. 2025;122:e2419625121.
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  37. SHI W, Yi X, Ruan H, Wang D, et al
    An animal model recapitulates human hepatic diseases associated with GATA6 mutations.
    Proc Natl Acad Sci U S A. 2025;122:e2317801121.
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    October 2024
  38. JIANG L, Qi X, Lai M, Zhou J, et al
    WDR20 prevents hepatocellular carcinoma senescence by orchestrating the simultaneous USP12/46-mediated deubiquitination of c-Myc.
    Proc Natl Acad Sci U S A. 2024;121:e2407904121.
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  39. BAI J, Jiang P, Ji L, Lam WKJ, et al
    Histone modifications of circulating nucleosomes are associated with changes in cell-free DNA fragmentation patterns.
    Proc Natl Acad Sci U S A. 2024;121:e2404058121.
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    August 2024
  40. GANGULY S, Rosenthal SB, Ishizuka K, Troutman TD, et al
    Lipid-associated macrophages' promotion of fibrosis resolution during MASH regression requires TREM2.
    Proc Natl Acad Sci U S A. 2024;121:e2405746121.
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    April 2024
  41. SHERMAN DJ, Liu L, Mamrosh JL, Xie J, et al
    The fatty liver disease-causing protein PNPLA3-I148M alters lipid droplet-Golgi dynamics.
    Proc Natl Acad Sci U S A. 2024;121:e2318619121.
    >> Share

  42. BAKIRI L, Hasenfuss SC, Guio-Carrion A, Thomsen MK, et al
    Liver cancer development driven by the AP-1/c-Jun~Fra-2 dimer through c-Myc.
    Proc Natl Acad Sci U S A. 2024;121:e2404188121.
    >> Share

  43. GU L, Du Y, Chen J, Hasan MN, et al
    Cullin 3 RING E3 ligase inactivation causes NRF2-dependent NADH reductive stress, hepatic lipodystrophy, and systemic insulin resistance.
    Proc Natl Acad Sci U S A. 2024;121:e2320934121.
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    February 2024
  44. DAS A, Cheng H, Wang Y, Kinch LN, et al
    The ubiquitin E3 ligase BFAR promotes degradation of PNPLA3.
    Proc Natl Acad Sci U S A. 2024;121:e2312291121.
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    January 2024
  45. HULLAHALLI K, Dailey KG, Hasegawa Y, Johnson WE, et al
    Reverse transcriptase inhibitors prevent liver abscess formation during Escherichia coli bloodstream infection.
    Proc Natl Acad Sci U S A. 2024;121:e2319162121.
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    December 2023
  46. SAKUMA I, Gaspar RC, Luukkonen PK, Kahn M, et al
    Lysophosphatidic acid triggers inflammation in the liver and white adipose tissue in rat models of 1-acyl-sn-glycerol-3-phosphate acyltransferase 2 deficiency and overnutrition.
    Proc Natl Acad Sci U S A. 2023;120:e2312666120.
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  47. HULLAHALLI K, Dailey KG, Hasegawa Y, Torres E, et al
    Genetic and immune determinants of E. coli liver abscess formation.
    Proc Natl Acad Sci U S A. 2023;120:e2310053120.
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    November 2023
  48. YUAN D, Hu J, Ju X, Putz EM, et al
    NMDAR antagonists suppress tumor progression by regulating tumor-associated macrophages.
    Proc Natl Acad Sci U S A. 2023;120:e2302126120.
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