August 2022
1. CHAN CY, Chiu DK, Yuen VW, Law CT, et al
   CFI-402257, a TTK inhibitor, effectively suppresses hepatocellular carcinoma.
   Proc Natl Acad Sci U S A. 2022;119:e2119514119.
   

   >> Share

   
   
2. KE H, Guay KP, Flotte TR, Gierasch LM, et al
   Secretion of functional alpha1-antitrypsin is cell type dependent: Implications for intramuscular delivery for gene therapy.
   Proc Natl Acad Sci U S A. 2022;119:e2206103119.
   

   >> Share

   
   April 2022
3. CHENG MT, Chen Y, Chen ZP, Liu X, et al
   Structural insights into the activation of autoinhibited human lipid flippase ATP8B1 upon substrate binding.
   Proc Natl Acad Sci U S A. 2022;119:e2118656119.
   

   >> Share

   
   March 2022
4. KAPS L, Huppertsberg A, Choteschovsky N, Klefenz A, et al
   pH-degradable, bisphosphonate-loaded nanogels attenuate liver fibrosis by repolarization of M2-type macrophages.
   Proc Natl Acad Sci U S A. 2022;119:e2122310119.
   

   >> Share

   
   
5. JOUFFE C, Weger BD, Martin E, Atger F, et al
   Disruption of the circadian clock component BMAL1 elicits an endocrine adaption impacting on insulin sensitivity and liver disease.
   Proc Natl Acad Sci U S A. 2022;119:e2200083119.
   

   >> Share

   
   January 2022
6. GAO T, Liu T, Ko CJ, Zhang L, et al
   Myeloid cell TBK1 restricts inflammatory responses.
   Proc Natl Acad Sci U S A. 2022;119.
   

   >> Share

   
   November 2021
7. VASHISTH M, Cho S, Irianto J, Xia Y, et al
   Scaling concepts in 'omics: Nuclear lamin-B scales with tumor growth and often predicts poor prognosis, unlike fibrosis.
   Proc Natl Acad Sci U S A. 2021;118.
   

   >> Share

   
   
8. HO WW, Gomes-Santos IL, Aoki S, Datta M, et al
   Dendritic cell paucity in mismatch repair-proficient colorectal cancer liver metastases limits immune checkpoint blockade efficacy.
   Proc Natl Acad Sci U S A. 2021;118.
   

   >> Share

   
   October 2021
9. KAN X, Zhang F, Zhou G, Ji H, et al
   Interventional real-time optical imaging guidance for complete tumor ablation.
   Proc Natl Acad Sci U S A. 2021;118.
   

   >> Share

   
   
10. DENG J, Yang H, Haak VM, Yang J, et al
    Eicosanoid regulation of debris-stimulated metastasis.
    Proc Natl Acad Sci U S A. 2021;118.
    

    >> Share

    
    September 2021
11. LUCERO MY, Tang Y, Zhang CJ, Su S, et al
    Activity-based photoacoustic probe for biopsy-free assessment of copper in murine models of Wilson's disease and liver metastasis.
    Proc Natl Acad Sci U S A. 2021;118.
    

    >> Share

    
    July 2021
12. BUGIDE S, Gupta R, Green MR, Wajapeyee N, et al
    EZH2 inhibits NK cell-mediated antitumor immunity by suppressing CXCL10 expression in an HDAC10-dependent manner.
    Proc Natl Acad Sci U S A. 2021;118.
    

    >> Share

    
    
13. NISHIO T, Koyama Y, Liu X, Rosenthal SB, et al
    Immunotherapy-based targeting of MSLN(+) activated portal fibroblasts is a strategy for treatment of cholestatic liver fibrosis.
    Proc Natl Acad Sci U S A. 2021;118.
    

    >> Share

    
    
14. DUCIMETIERE L, Lucchiari G, Litscher G, Nater M, et al
    Conventional NK cells and tissue-resident ILC1s join forces to control liver metastasis.
    Proc Natl Acad Sci U S A. 2021;118.
    

    >> Share

    
    June 2021
15. PATEL SJ, Protchenko O, Shakoury-Elizeh M, Baratz E, et al
    The iron chaperone and nucleic acid-binding activities of poly(rC)-binding protein 1 are separable and independently essential.
    Proc Natl Acad Sci U S A. 2021;118.
    

    >> Share

    
    April 2021
16. DARLYUK-SAADON I, Bai C, Heng CKM, Gilad N, et al
    Active p38alpha causes macrovesicular fatty liver in mice.
    Proc Natl Acad Sci U S A. 2021;118.
    

    >> Share

    
    March 2021
17. MULLER K, Honcharova-Biletska H, Koppe C, Egger M, et al
    JNK signaling prevents biliary cyst formation through a CASPASE-8-dependent function of RIPK1 during aging.
    Proc Natl Acad Sci U S A. 2021;118.
    

    >> Share

    
    
18. PICCOLO P, Ferriero R, Barbato A, Attanasio S, et al
    Up-regulation of miR-34b/c by JNK and FOXO3 protects from liver fibrosis.
    Proc Natl Acad Sci U S A. 2021;118.
    

    >> Share

    
    January 2021
19. CHIBAYA L, Karim B, Zhang H, Jones SN, et al
    Mdm2 phosphorylation by Akt regulates the p53 response to oxidative stress to promote cell proliferation and tumorigenesis.
    Proc Natl Acad Sci U S A. 2021;118.
    

    >> Share

    
    
20. WANG Q, Kim SY, Matsushita H, Wang Z, et al
    Oral administration of PEGylated TLR7 ligand ameliorates alcohol-associated liver disease via the induction of IL-22.
    Proc Natl Acad Sci U S A. 2021;118.
    

    >> Share

    
    December 2020
21. CONCILLI M, Petruzzelli R, Parisi S, Catalano F, et al
    Pharmacoproteomics pinpoints HSP70 interaction for correction of the most frequent Wilson disease-causing mutant of ATP7B.
    Proc Natl Acad Sci U S A. 2020;117:32453-32463.
    

    >> Share

    
    
22. BAILEY AL, Kang LI, de Assis Barros D'Elia Zanella LGF, Silveira CGT, et al
    Consumptive coagulopathy of severe yellow fever occurs independently of hepatocellular tropism and massive hepatic injury.
    Proc Natl Acad Sci U S A. 2020;117:32648-32656.
    

    >> Share

    
    
23. CHEN W, Li X, Liu C, He J, et al
    beta-Cyclodextrin modified Pt(II) metallacycle-based supramolecular hyperbranched polymer assemblies for DOX delivery to liver cancer cells.
    Proc Natl Acad Sci U S A. 2020;117:30942-30948.
    

    >> Share

    
    
24. YUEH MF, He F, Chen C, Vu C, et al
    Triclosan leads to dysregulation of the metabolic regulator FGF21 exacerbating high fat diet-induced nonalcoholic fatty liver disease.
    Proc Natl Acad Sci U S A. 2020;117:31259-31266.
    

    >> Share

    
    November 2020
25. FLORES-COSTA R, Duran-Guell M, Casulleras M, Lopez-Vicario C, et al
    Stimulation of soluble guanylate cyclase exerts antiinflammatory actions in the liver through a VASP/NF-kappaB/NLRP3 inflammasome circuit.
    Proc Natl Acad Sci U S A. 2020;117:28263-28274.
    

    >> Share

    
    
26. LIU S, Luttrell LM, Premont RT, Rockey DC, et al
    Reply to Schierwagen et al.: beta-Arrestins in liver disease.
    Proc Natl Acad Sci U S A. 2020;117:27085-27086.
    

    >> Share

    
    
27. SCHIERWAGEN R, Dietrich P, Klein S, Uschner FE, et al
    beta-Arrestin2 is increased in liver fibrosis in humans and rodents.
    Proc Natl Acad Sci U S A. 2020;117:27082-27084.
    

    >> Share

    
    October 2020
28. WANG C, Tang H, Geng A, Dai B, et al
    Rational combination therapy for hepatocellular carcinoma with PARP1 and DNA-PK inhibitors.
    Proc Natl Acad Sci U S A. 2020;117:26356-26365.
    

    >> Share

    
    September 2020
29. FISHBEIN A, Wang W, Yang H, Yang J, et al
    Resolution of eicosanoid/cytokine storm prevents carcinogen and inflammation-initiated hepatocellular cancer progression.
    Proc Natl Acad Sci U S A. 2020;117:21576-21587.
    

    >> Share

    
    August 2020
30. ITATANI Y, Yamamoto T, Zhong C, Molinolo AA, et al
    Suppressing neutrophil-dependent angiogenesis abrogates resistance to anti-VEGF antibody in a genetic model of colorectal cancer.
    Proc Natl Acad Sci U S A. 2020 Aug 19. pii: 2008112117.
    

    >> Share

    
    July 2020
31. WU H, Reizel T, Wang YJ, Lapiro JL, et al
    A negative reciprocal regulatory axis between cyclin D1 and HNF4alpha modulates cell cycle progression and metabolism in the liver.
    Proc Natl Acad Sci U S A. 2020;117:17177-17186.
    

    >> Share

    
    June 2020
32. TAN S, Zhao J, Sun Z, Cao S, et al
    Hepatocyte-specific TAK1 deficiency drives RIPK1 kinase-dependent inflammation to promote liver fibrosis and hepatocellular carcinoma.
    Proc Natl Acad Sci U S A. 2020;117:14231-14242.
    

    >> Share

    
    May 2020
33. LIU S, Luttrell LM, Premont RT, Rockey DC, et al
    beta-Arrestin2 is a critical component of the GPCR-eNOS signalosome.
    Proc Natl Acad Sci U S A. 2020;117:11483-11492.
    

    >> Share

    
    
34. LUTHER J, Khan S, Gala MK, Kedrin D, et al
    Hepatic gap junctions amplify alcohol liver injury by propagating cGAS-mediated IRF3 activation.
    Proc Natl Acad Sci U S A. 2020;117:11667-11673.
    

    >> Share

    
    
35. NILSSON A, Haanstra JR, Engqvist M, Gerding A, et al
    Quantitative analysis of amino acid metabolism in liver cancer links glutamate excretion to nucleotide synthesis.
    Proc Natl Acad Sci U S A. 2020;117:10294-10304.
    

    >> Share

    
    April 2020
36. NOZAKI Y, Petersen MC, Zhang D, Vatner DF, et al
    Metabolic control analysis of hepatic glycogen synthesis in vivo.
    Proc Natl Acad Sci U S A. 2020;117:8166-8176.
    

    >> Share

    
    March 2020
37. LUUKKONEN PK, Dufour S, Lyu K, Zhang XM, et al
    Effect of a ketogenic diet on hepatic steatosis and hepatic mitochondrial metabolism in nonalcoholic fatty liver disease.
    Proc Natl Acad Sci U S A. 2020;117:7347-7354.
    

    >> Share

    
    
38. LIU M, Yan Q, Sun Y, Nam Y, et al
    A hepatocyte differentiation model reveals two subtypes of liver cancer with different oncofetal properties and therapeutic targets.
    Proc Natl Acad Sci U S A. 2020;117:6103-6113.
    

    >> Share

    
    
39. JIANG H, Cao HJ, Ma N, Bao WD, et al
    Chromatin remodeling factor ARID2 suppresses hepatocellular carcinoma metastasis via DNMT1-Snail axis.
    Proc Natl Acad Sci U S A. 2020;117:4770-4780.
    

    >> Share

    
    January 2020
40. WOOTON-KEE CR, Robertson M, Zhou Y, Dong B, et al
    Metabolic dysregulation in the Atp7b (-/-) Wilson's disease mouse model.
    Proc Natl Acad Sci U S A. 2020;117:2076-2083.
    

    >> Share

    
    
41. WINKLER I, Bitter C, Winkler S, Weichenhan D, et al
    Identification of Ppargamma-modulated miRNA hubs that target the fibrotic tumor microenvironment.
    Proc Natl Acad Sci U S A. 2020;117:454-463.
    

    >> Share

    
    October 2019
42. TRUONG B, Allegri G, Liu XB, Burke KE, et al
    Lipid nanoparticle-targeted mRNA therapy as a treatment for the inherited metabolic liver disorder arginase deficiency.
    Proc Natl Acad Sci U S A. 2019;116:21150-21159.
    

    >> Share

    
    September 2019
43. LIU K, Theusch E, Zhou Y, Ashuach T, et al
    GeneFishing to reconstruct context specific portraits of biological processes.
    Proc Natl Acad Sci U S A. 2019;116:18943-18950.
    

    >> Share

    
    July 2019
44. KINGSTON BR, Syed AM, Ngai J, Sindhwani S, et al
    Assessing micrometastases as a target for nanoparticles using 3D microscopy and machine learning.
    Proc Natl Acad Sci U S A. 2019;116:14937-14946.
    

    >> Share

    
    
45. WANG L, Mazagova M, Pan C, Yang S, et al
    YIPF6 controls sorting of FGF21 into COPII vesicles and promotes obesity.
    Proc Natl Acad Sci U S A. 2019 Jul 9. pii: 1904360116.
    

    >> Share

    
    
46. HUA G, Zein N, Paulen L, Chambon P, et al
    The glucocorticoid receptor agonistic modulators CpdX and CpdX-D3 do not generate the debilitating effects of synthetic glucocorticoids.
    Proc Natl Acad Sci U S A. 2019;116:14200-14209.
    

    >> Share

    
    
47. TORRES C, Mancinelli G, Cordoba-Chacon J, Viswakarma N, et al
    p110gamma deficiency protects against pancreatic carcinogenesis yet predisposes to diet-induced hepatotoxicity.
    Proc Natl Acad Sci U S A. 2019 Jul 2. pii: 1813012116.
    

    >> Share

    
    
48. MIYAUCHI T, Uchida Y, Kadono K, Hirao H, et al
    Up-regulation of FOXO1 and reduced inflammation by beta-hydroxybutyric acid are essential diet restriction benefits against liver injury.
    Proc Natl Acad Sci U S A. 2019;116:13533-13542.
    

    >> Share

    
    

Free Medical Abstracts
Privacy Policy
Sponsors
Share