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Articles published in
Proc Natl Acad Sci U S A
    April 2024
  1. SHERMAN DJ, Liu L, Mamrosh JL, Xie J, et al
    The fatty liver disease-causing protein PNPLA3-I148M alters lipid droplet-Golgi dynamics.
    Proc Natl Acad Sci U S A. 2024;121:e2318619121.
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  2. BAKIRI L, Hasenfuss SC, Guio-Carrion A, Thomsen MK, et al
    Liver cancer development driven by the AP-1/c-Jun~Fra-2 dimer through c-Myc.
    Proc Natl Acad Sci U S A. 2024;121:e2404188121.
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  3. GU L, Du Y, Chen J, Hasan MN, et al
    Cullin 3 RING E3 ligase inactivation causes NRF2-dependent NADH reductive stress, hepatic lipodystrophy, and systemic insulin resistance.
    Proc Natl Acad Sci U S A. 2024;121:e2320934121.
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    February 2024
  4. DAS A, Cheng H, Wang Y, Kinch LN, et al
    The ubiquitin E3 ligase BFAR promotes degradation of PNPLA3.
    Proc Natl Acad Sci U S A. 2024;121:e2312291121.
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    January 2024
  5. HULLAHALLI K, Dailey KG, Hasegawa Y, Johnson WE, et al
    Reverse transcriptase inhibitors prevent liver abscess formation during Escherichia coli bloodstream infection.
    Proc Natl Acad Sci U S A. 2024;121:e2319162121.
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    December 2023
  6. SAKUMA I, Gaspar RC, Luukkonen PK, Kahn M, et al
    Lysophosphatidic acid triggers inflammation in the liver and white adipose tissue in rat models of 1-acyl-sn-glycerol-3-phosphate acyltransferase 2 deficiency and overnutrition.
    Proc Natl Acad Sci U S A. 2023;120:e2312666120.
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  7. HULLAHALLI K, Dailey KG, Hasegawa Y, Torres E, et al
    Genetic and immune determinants of E. coli liver abscess formation.
    Proc Natl Acad Sci U S A. 2023;120:e2310053120.
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    November 2023
  8. YUAN D, Hu J, Ju X, Putz EM, et al
    NMDAR antagonists suppress tumor progression by regulating tumor-associated macrophages.
    Proc Natl Acad Sci U S A. 2023;120:e2302126120.
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    August 2023
  9. FANG LZ, Linehan V, Licursi M, Alberto CO, et al
    Prostaglandin E(2) activates melanin-concentrating hormone neurons to drive diet-induced obesity.
    Proc Natl Acad Sci U S A. 2023;120:e2302809120.
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    July 2023
  10. LIU B, Shen H, He J, Jin B, et al
    Cytoskeleton remodeling mediated by circRNA-YBX1 phase separation suppresses the metastasis of liver cancer.
    Proc Natl Acad Sci U S A. 2023;120:e2220296120.
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  11. GU Z, Wang L, Dong Q, Xu K, et al
    Aberrant LYZ expression in tumor cells serves as the potential biomarker and target for HCC and promotes tumor progression via csGRP78.
    Proc Natl Acad Sci U S A. 2023;120:e2215744120.
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    May 2023
  12. GU L, Zhu Y, Lee M, Nguyen A, et al
    Angiotensin II receptor inhibition ameliorates liver fibrosis and enhances hepatocellular carcinoma infiltration by effector T cells.
    Proc Natl Acad Sci U S A. 2023;120:e2300706120.
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  13. ZHANG J, Ning Y, Zhu H, Rotile NJ, et al
    Fast detection of liver fibrosis with collagen-binding single-nanometer iron oxide nanoparticles via T(1)-weighted MRI.
    Proc Natl Acad Sci U S A. 2023;120:e2220036120.
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    April 2023
  14. LONEKER AE, Alisafaei F, Kant A, Li D, et al
    Lipid droplets are intracellular mechanical stressors that impair hepatocyte function.
    Proc Natl Acad Sci U S A. 2023;120:e2216811120.
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    January 2023
  15. LUUKKONEN PK, Sakuma I, Gaspar RC, Mooring M, et al
    Inhibition of HSD17B13 protects against liver fibrosis by inhibition of pyrimidine catabolism in nonalcoholic steatohepatitis.
    Proc Natl Acad Sci U S A. 2023;120:e2217543120.
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  16. QU M, Zhang G, Qu H, Vu A, et al
    Circadian regulator BMAL1::CLOCK promotes cell proliferation in hepatocellular carcinoma by controlling apoptosis and cell cycle.
    Proc Natl Acad Sci U S A. 2023;120:e2214829120.
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    December 2022
  17. CHEN W, Wen L, Bao Y, Tang Z, et al
    Gut flora disequilibrium promotes the initiation of liver cancer by modulating tryptophan metabolism and up-regulating SREBP2.
    Proc Natl Acad Sci U S A. 2022;119:e2203894119.
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  18. ZHAO C, Matalonga J, Lancman JJ, Liu L, et al
    Regenerative failure of intrahepatic biliary cells in Alagille syndrome rescued by elevated Jagged/Notch/Sox9 signaling.
    Proc Natl Acad Sci U S A. 2022;119:e2201097119.
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    November 2022
  19. OSBORN LJ, Schultz K, Massey W, DeLucia B, et al
    A gut microbial metabolite of dietary polyphenols reverses obesity-driven hepatic steatosis.
    Proc Natl Acad Sci U S A. 2022;119:e2202934119.
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  20. ZHOU Q, Kang G, Jiang P, Qiao R, et al
    Epigenetic analysis of cell-free DNA by fragmentomic profiling.
    Proc Natl Acad Sci U S A. 2022;119:e2209852119.
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    October 2022
  21. TAO Z, Cui Y, Xu X, Han T, et al
    FGFR redundancy limits the efficacy of FGFR4-selective inhibitors in hepatocellular carcinoma.
    Proc Natl Acad Sci U S A. 2022;119:e2208844119.
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    September 2022
  22. LIU F, Gai X, Wu Y, Zhang B, et al
    Oncogenic beta-catenin stimulation of AKT2-CAD-mediated pyrimidine synthesis is targetable vulnerability in liver cancer.
    Proc Natl Acad Sci U S A. 2022;119:e2202157119.
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  23. YAMADA K, Motohashi S, Oikawa T, Tago N, et al
    Extended-synaptotagmin 1 engages in unconventional protein secretion mediated via SEC22B(+) vesicle pathway in liver cancer.
    Proc Natl Acad Sci U S A. 2022;119:e2202730119.
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    August 2022
  24. CHAN CY, Chiu DK, Yuen VW, Law CT, et al
    CFI-402257, a TTK inhibitor, effectively suppresses hepatocellular carcinoma.
    Proc Natl Acad Sci U S A. 2022;119:e2119514119.
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  25. KE H, Guay KP, Flotte TR, Gierasch LM, et al
    Secretion of functional alpha1-antitrypsin is cell type dependent: Implications for intramuscular delivery for gene therapy.
    Proc Natl Acad Sci U S A. 2022;119:e2206103119.
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    April 2022
  26. CHENG MT, Chen Y, Chen ZP, Liu X, et al
    Structural insights into the activation of autoinhibited human lipid flippase ATP8B1 upon substrate binding.
    Proc Natl Acad Sci U S A. 2022;119:e2118656119.
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    March 2022
  27. KAPS L, Huppertsberg A, Choteschovsky N, Klefenz A, et al
    pH-degradable, bisphosphonate-loaded nanogels attenuate liver fibrosis by repolarization of M2-type macrophages.
    Proc Natl Acad Sci U S A. 2022;119:e2122310119.
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  28. JOUFFE C, Weger BD, Martin E, Atger F, et al
    Disruption of the circadian clock component BMAL1 elicits an endocrine adaption impacting on insulin sensitivity and liver disease.
    Proc Natl Acad Sci U S A. 2022;119:e2200083119.
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    January 2022
  29. GAO T, Liu T, Ko CJ, Zhang L, et al
    Myeloid cell TBK1 restricts inflammatory responses.
    Proc Natl Acad Sci U S A. 2022;119.
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    November 2021
  30. VASHISTH M, Cho S, Irianto J, Xia Y, et al
    Scaling concepts in 'omics: Nuclear lamin-B scales with tumor growth and often predicts poor prognosis, unlike fibrosis.
    Proc Natl Acad Sci U S A. 2021;118.
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  31. HO WW, Gomes-Santos IL, Aoki S, Datta M, et al
    Dendritic cell paucity in mismatch repair-proficient colorectal cancer liver metastases limits immune checkpoint blockade efficacy.
    Proc Natl Acad Sci U S A. 2021;118.
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    October 2021
  32. KAN X, Zhang F, Zhou G, Ji H, et al
    Interventional real-time optical imaging guidance for complete tumor ablation.
    Proc Natl Acad Sci U S A. 2021;118.
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  33. DENG J, Yang H, Haak VM, Yang J, et al
    Eicosanoid regulation of debris-stimulated metastasis.
    Proc Natl Acad Sci U S A. 2021;118.
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    September 2021
  34. LUCERO MY, Tang Y, Zhang CJ, Su S, et al
    Activity-based photoacoustic probe for biopsy-free assessment of copper in murine models of Wilson's disease and liver metastasis.
    Proc Natl Acad Sci U S A. 2021;118.
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    July 2021
  35. BUGIDE S, Gupta R, Green MR, Wajapeyee N, et al
    EZH2 inhibits NK cell-mediated antitumor immunity by suppressing CXCL10 expression in an HDAC10-dependent manner.
    Proc Natl Acad Sci U S A. 2021;118.
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  36. NISHIO T, Koyama Y, Liu X, Rosenthal SB, et al
    Immunotherapy-based targeting of MSLN(+) activated portal fibroblasts is a strategy for treatment of cholestatic liver fibrosis.
    Proc Natl Acad Sci U S A. 2021;118.
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  37. DUCIMETIERE L, Lucchiari G, Litscher G, Nater M, et al
    Conventional NK cells and tissue-resident ILC1s join forces to control liver metastasis.
    Proc Natl Acad Sci U S A. 2021;118.
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    June 2021
  38. PATEL SJ, Protchenko O, Shakoury-Elizeh M, Baratz E, et al
    The iron chaperone and nucleic acid-binding activities of poly(rC)-binding protein 1 are separable and independently essential.
    Proc Natl Acad Sci U S A. 2021;118.
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    April 2021
  39. DARLYUK-SAADON I, Bai C, Heng CKM, Gilad N, et al
    Active p38alpha causes macrovesicular fatty liver in mice.
    Proc Natl Acad Sci U S A. 2021;118.
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    March 2021
  40. SONG JS, Chang CC, Wu CH, Dinh TK, et al
    A highly selective and potent CXCR4 antagonist for hepatocellular carcinoma treatment.
    Proc Natl Acad Sci U S A. 2021;118:e2015433118.
    >> Share

  41. MULLER K, Honcharova-Biletska H, Koppe C, Egger M, et al
    JNK signaling prevents biliary cyst formation through a CASPASE-8-dependent function of RIPK1 during aging.
    Proc Natl Acad Sci U S A. 2021;118.
    >> Share

  42. PICCOLO P, Ferriero R, Barbato A, Attanasio S, et al
    Up-regulation of miR-34b/c by JNK and FOXO3 protects from liver fibrosis.
    Proc Natl Acad Sci U S A. 2021;118.
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    January 2021
  43. CHIBAYA L, Karim B, Zhang H, Jones SN, et al
    Mdm2 phosphorylation by Akt regulates the p53 response to oxidative stress to promote cell proliferation and tumorigenesis.
    Proc Natl Acad Sci U S A. 2021;118.
    >> Share

  44. WANG Q, Kim SY, Matsushita H, Wang Z, et al
    Oral administration of PEGylated TLR7 ligand ameliorates alcohol-associated liver disease via the induction of IL-22.
    Proc Natl Acad Sci U S A. 2021;118.
    >> Share


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