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Articles published in
Oncogene
    December 2025
  1. ZHANG Y, Xiong C, Jiang Z, Wang X, et al
    Unveiling EMC6 as a novel pathogenic determinant in hepatocellular carcinoma: orchestration of lipid metabolism through regulation of lipid droplet-associated enzyme HSD17B13.
    Oncogene. 2025 Dec 3. doi: 10.1038/s41388-025-03649.
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    November 2025
  2. CHEN W, Lin C, Wang L, Yu Z, et al
    Hepatitis B virus X protein promotes the progression and immune escape of hepatocellular carcinoma by activating KLF16-C12orf49-PD-L1 axis.
    Oncogene. 2025 Nov 14. doi: 10.1038/s41388-025-03625.
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  3. HUANG H, Xiang Y, Deng Y, Liu Q, et al
    WBP11 inhibits UFL1-mediated UFMylation of NONO to drive hepatocellular carcinoma progression.
    Oncogene. 2025 Nov 3. doi: 10.1038/s41388-025-03620.
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    October 2025
  4. CHEN Q, Liang Y, Li Y, Li X, et al
    PSME3 drives Tregs infiltration and anti-PD1 resistance in hepatocellular carcinoma by regulating FBXL7/PTEN-mediated metabolic reprogramming.
    Oncogene. 2025 Oct 15. doi: 10.1038/s41388-025-03593.
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  5. TSUCHIYA H, Hanaki T, Sakabe T, Tokuyasu N, et al
    Immune evasion from macrophages by NEAT1-induced CD24 in liver cancer.
    Oncogene. 2025;44:3652-3664.
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    September 2025
  6. LI J, Mao S, Yang S, Lou Y, et al
    Targeting JMJD6/PPARgamma/GPX4 axis overcomes ferroptosis resistance and enhances therapeutic efficacy in hepatocellular carcinoma.
    Oncogene. 2025 Sep 30. doi: 10.1038/s41388-025-03581.
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  7. WU Z, Duan W, Xiong Y, Liu J, et al
    Publisher Correction: NeuroD1 drives a KAT2A-FDFT1 signaling axis to promote cholesterol biosynthesis and hepatocellular carcinoma progression via histone H3K27 acetylation.
    Oncogene. 2025 Sep 22. doi: 10.1038/s41388-025-03574.
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  8. ZHAO J, Cui M, Yao X, Jiang Z, et al
    Targeting TFAM downregulation mediated mtDNA-NLRP3 pathway suppresses TAM infiltration and HCC progression.
    Oncogene. 2025;44:2956-2969.
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  9. WU Z, Duan W, Xiong Y, Liu J, et al
    NeuroD1 drives a KAT2A-FDFT1 signaling axis to promote cholesterol biosynthesis and hepatocellular carcinoma progression via histone H3K27 acetylation.
    Oncogene. 2025 Sep 1. doi: 10.1038/s41388-025-03534.
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    August 2025
  10. SUN C, Cai S, Yang J, Du M, et al
    OTUB1 antagonizes TRIM21 to induce deubiquitination of SPHK1 and promote the progression of hepatocellular carcinoma.
    Oncogene. 2025 Aug 30. doi: 10.1038/s41388-025-03556.
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  11. HAN H, Gong C, Zhang Y, Liu C, et al
    RBM30 recruits DOT1L to activate STAT1 transcription and drive immune evasion in hepatocellular carcinoma.
    Oncogene. 2025 Aug 29. doi: 10.1038/s41388-025-03550.
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  12. HAN J, Wang F, Lan Y, Wang J, et al
    Retraction Note to: KIFC1 regulated by miR-532-3p promotes epithelial-to-mesenchymal transition and metastasis of hepatocellular carcinoma via gankyrin/AKT signaling.
    Oncogene. 2025 Aug 11. doi: 10.1038/s41388-025-03527.
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    July 2025
  13. GUO S, Zhang Q, Ma J, Zou Y, et al
    PABPN1-C5 axis promotes hepatocellular carcinoma progression via NF-kappaB activation.
    Oncogene. 2025 Jul 28. doi: 10.1038/s41388-025-03501.
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    May 2025
  14. GENG X, Li M, Zhang L, Cai Y, et al
    P5CS deacetylation mediated by SIRT2 facilitates tumor growth by enhancing mitochondrial respiration in hepatocellular carcinoma.
    Oncogene. 2025 May 27. doi: 10.1038/s41388-025-03456.
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  15. SOUDAH N, Baskin A, Darash-Yahana M, Darlyuk-Saadon I, et al
    Erk1(R84H) is an oncoprotein that causes hepatocellular carcinoma in mice and imposes a rigorous negative feedback loop.
    Oncogene. 2025 May 20. doi: 10.1038/s41388-025-03437.
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  16. DENG L, Tang J, Yang H, Cheng C, et al
    Retraction Note: MTA1 modulated by miR-30e contributes to epithelial-to-mesenchymal transition in hepatocellular carcinoma through an ErbB2-dependent pathway.
    Oncogene. 2025 May 12. doi: 10.1038/s41388-025-03433.
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  17. SHU Y, Tao Q, Xu Q, Chen Y, et al
    Loss of NUMB promotes hepatomegaly and hepatocellular carcinoma through the AKT/glycogen/hippo signaling.
    Oncogene. 2025 May 3. doi: 10.1038/s41388-025-03430.
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  18. SHA N, Zhou B, Hou G, Xi Z, et al
    The protection of UCK2 protein stability by GART maintains pyrimidine salvage synthesis for HCC growth under glucose limitation.
    Oncogene. 2025;44:1078-1092.
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    April 2025
  19. HU H, Zhan X, Xiong Y, Yuan R, et al
    Non-classic deubiquitinase USP13 inhibits bladder cancer metastasis through destabilizing cytoplasmic KDM3A.
    Oncogene. 2025 Apr 19. doi: 10.1038/s41388-025-03410.
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  20. ZHANG H, Kong X, Qu H, Gao Y, et al
    MYCBP2-mediated HNF4alpha ubiquitination reprogrammed lipid metabolism in MASH-associated hepatocellular carcinoma.
    Oncogene. 2025 Apr 3. doi: 10.1038/s41388-025-03373.
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  21. LI D, Gao Z, Zhang Z, Chen H, et al
    Suprabasin promotes gastric cancer liver metastasis via hepatic stellate cells-mediated EGF/CCL2/JAK2 intercellular signaling pathways.
    Oncogene. 2025 Apr 3. doi: 10.1038/s41388-025-03370.
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  22. ZHANG GP, Song ZB, Chen DH, Yu Y, et al
    Syntaxin-6 mediated autophagy confers lenvatinib resistance in hepatocellular carcinoma.
    Oncogene. 2025 Apr 3. doi: 10.1038/s41388-025-03371.
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  23. LU Y, Li X, Liu H, Xue J, et al
    Retraction Note: beta-Trcp and CK1delta-mediated degradation of LZTS2 activates PI3K/AKT signaling to drive tumorigenesis and metastasis in hepatocellular carcinoma.
    Oncogene. 2025;44:931.
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    March 2025
  24. JIANG S, Jiang L, Xu Y, Ma Y, et al
    USP5 deubiquitinates and stabilizes IMPDH2, to promote hepatocellular carcinoma progression.
    Oncogene. 2025 Mar 31. doi: 10.1038/s41388-025-03355.
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  25. ZHOU J, Wang J, Yang L, Fu T, et al
    N6-methyadenosine-modified YWHAE mRNA promotes proliferation and inhibits ferroptosis in hepatoblastoma by mediating SLC7A11 expression.
    Oncogene. 2025 Mar 12. doi: 10.1038/s41388-025-03334.
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  26. ZHU J, Wang L, Nie X, Ou S, et al
    RBMS3-loss impedes TRIM21-induced ubiquitination of ANGPT2 in an RNA-independent manner and drives sorafenib resistance in hepatocellular carcinoma.
    Oncogene. 2025 Mar 11. doi: 10.1038/s41388-025-03335.
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  27. LIANG Y, Qiao L, Qian Q, Zhang R, et al
    Integrated single-cell and spatial transcriptomic profiling reveals that CD177(+) Tregs enhance immunosuppression through apoptosis and resistance to immunotherapy in hepatocellular carcinoma.
    Oncogene. 2025 Mar 7. doi: 10.1038/s41388-025-03330.
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  28. ZHANG B, Zhou Y, Xu X, Xu G, et al
    RBM39 promotes hepatocarcinogenesis by regulating RFX1's alternative splicing and subsequent activation of integrin signaling pathway.
    Oncogene. 2025 Mar 3. doi: 10.1038/s41388-025-03327.
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  29. XU J, Li Y, Wang G, Chen D, et al
    Impaired mitochondrial degradation of CHCHD2 promotes metabolic dysfunction-associated steatohepatitis-related hepatocellular carcinoma by upregulating VEGFA.
    Oncogene. 2025 Mar 1. doi: 10.1038/s41388-025-03321.
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    February 2025
  30. LI Y, Ouyang Q, Chen Z, Zhou D, et al
    Novel role of general transcript factor IIH subunit 2 (GTF2H2) in the development and sex disparity of hepatocellular carcinoma.
    Oncogene. 2025 Feb 19. doi: 10.1038/s41388-025-03301.
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    November 2024
  31. ZHUANG M, Liu J, Li Y, Zhang J, et al
    PD-L1 promotes tumor metastasis by regulating the infiltration of FGFBP2(+)Tm cells in colorectal cancer.
    Oncogene. 2024 Nov 18. doi: 10.1038/s41388-024-03223.
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    October 2024
  32. XING H, Gu X, Liu Y, Xu L, et al
    NSUN2 regulates Wnt signaling pathway depending on the m5C RNA modification to promote the progression of hepatocellular carcinoma.
    Oncogene. 2024 Oct 7. doi: 10.1038/s41388-024-03184.
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  33. LI X, Hu Z, Shi Q, Qiu W, et al
    Elevated choline drives KLF5-dominated transcriptional reprogramming to facilitate liver cancer progression.
    Oncogene. 2024;43:3121-3136.
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  34. LIU Z, Hu Q, Luo Q, Zhang G, et al
    NUP37 accumulation mediated by TRIM28 enhances lipid synthesis to accelerate HCC progression.
    Oncogene. 2024;43:3255-3267.
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    September 2024
  35. XIE P, Wu M, Wang H, Zhang B, et al
    GOLM1 dictates acquired Lenvatinib resistance by a GOLM1-CSN5 positive feedback loop upon EGFR signaling activation in hepatocellular carcinoma.
    Oncogene. 2024 Sep 9. doi: 10.1038/s41388-024-03153.
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  36. DU J, Bai D, Gu C, Zhao J, et al
    Sorafenib-mediated cleavage of p62 initiates cellular senescence as a mechanism to evade its anti-hepatocellular carcinoma efficacy.
    Oncogene. 2024 Sep 4. doi: 10.1038/s41388-024-03142.
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    August 2024
  37. HAN H, Shi Q, Zhang Y, Ding M, et al
    RBM12 drives PD-L1-mediated immune evasion in hepatocellular carcinoma by increasing JAK1 mRNA translation.
    Oncogene. 2024 Aug 26. doi: 10.1038/s41388-024-03140.
    >> Share

  38. CUI M, Liu Z, Wang S, Bae S, et al
    CRISPR-based dissection of microRNA-23a ~ 27a ~ 24-2 cluster functionality in hepatocellular carcinoma.
    Oncogene. 2024 Aug 7. doi: 10.1038/s41388-024-03115.
    >> Share

  39. TANG X, Gao L, Jiang X, Hou Z, et al
    Single-cell profiling reveals altered immune landscape and impaired NK cell function in gastric cancer liver metastasis.
    Oncogene. 2024;43:2635-2646.
    >> Share

    July 2024
  40. ZHANG T, Zhao F, Hu Y, Wei J, et al
    Environmental monobutyl phthalate exposure promotes liver cancer via reprogrammed cholesterol metabolism and activation of the IRE1alpha-XBP1s pathway.
    Oncogene. 2024;43:2355-2370.
    >> Share

  41. LI W, Guo Z, Zhou Z, Zhou Z, et al
    Distinguishing high-metastasis-potential circulating tumor cells through fluidic shear stress in a bloodstream-like microfluidic circulatory system.
    Oncogene. 2024;43:2295-2306.
    >> Share

    June 2024
  42. GU J, Xu X, Li X, Yue L, et al
    Tumor-resident microbiota contributes to colorectal cancer liver metastasis by lactylation and immune modulation.
    Oncogene. 2024 Jun 18. doi: 10.1038/s41388-024-03080.
    >> Share

  43. KE R, Viswakarma N, Menhart M, Singh SK, et al
    MLK3 promotes prooncogenic signaling in hepatocellular carcinoma via TGFbeta pathway.
    Oncogene. 2024 Jun 10. doi: 10.1038/s41388-024-03055.
    >> Share

  44. LI X, He W, Chen X, Zhang Y, et al
    TRIM45 facilitates NASH-progressed HCC by promoting fatty acid synthesis via catalyzing FABP5 ubiquitylation.
    Oncogene. 2024;43:2063-2077.
    >> Share

    March 2024
  45. DENG T, Zhao J, Tong Y, Chen Z, et al
    Crosstalk between endothelial progenitor cells and HCC through periostin/CCL2/CD36 supports formation of the pro-metastatic microenvironment in HCC.
    Oncogene. 2024;43:944-961.
    >> Share

    February 2024
  46. ZHANG T, Zhao F, Zhang Y, Shi JH, et al
    Targeting the IRE1alpha-XBP1s axis confers selective vulnerability in hepatocellular carcinoma with activated Wnt signaling.
    Oncogene. 2024 Feb 28. doi: 10.1038/s41388-024-02988.
    >> Share

  47. FENG Z, Yin J, Zhang Z, Chen Z, et al
    O-GlcNAcylation of E3 ubiquitin ligase SKP2 promotes hepatocellular carcinoma proliferation.
    Oncogene. 2024 Feb 23. doi: 10.1038/s41388-024-02977.
    >> Share

  48. LI B, Xiong X, Xu J, Peng D, et al
    METTL3-mediated m(6)A modification of lncRNA TSPAN12 promotes metastasis of hepatocellular carcinoma through SENP1-depentent deSUMOylation of EIF3I.
    Oncogene. 2024 Feb 19. doi: 10.1038/s41388-024-02970.
    >> Share

    January 2024
  49. GENG L, Zhu M, Luo D, Chen H, et al
    TKT-PARP1 axis induces radioresistance by promoting DNA double-strand break repair in hepatocellular carcinoma.
    Oncogene. 2024 Jan 12. doi: 10.1038/s41388-023-02935.
    >> Share

  50. GU X, Li P, Gao X, Ru Y, et al
    RNA 5-methylcytosine writer NSUN5 promotes hepatocellular carcinoma cell proliferation via a ZBED3-dependent mechanism.
    Oncogene. 2024 Jan 5. doi: 10.1038/s41388-023-02931.
    >> Share

    December 2023
  51. WANG C, Chen Z, Yi Y, Ding Y, et al
    RBM45 reprograms lipid metabolism promoting hepatocellular carcinoma via Rictor and ACSL1/ACSL4.
    Oncogene. 2023 Dec 1. doi: 10.1038/s41388-023-02902.
    >> Share

    November 2023
  52. CAO K, Wang R, Li L, Liao Y, et al
    Targeting DDX11 promotes PARP inhibitor sensitivity in hepatocellular carcinoma by attenuating BRCA2-RAD51 mediated homologous recombination.
    Oncogene. 2023 Nov 25. doi: 10.1038/s41388-023-02898.
    >> Share

  53. CHEN J, Ning D, Du P, Liu Q, et al
    USP11 potentiates HGF/AKT signaling and drives metastasis in hepatocellular carcinoma.
    Oncogene. 2023 Nov 16. doi: 10.1038/s41388-023-02847.
    >> Share

  54. LIU F, Liao Z, Zhang Z
    MYC in liver cancer: mechanisms and targeted therapy opportunities.
    Oncogene. 2023;42:3303-3318.
    >> Share

    September 2023
  55. ZHOU J, Xu W, Wu Y, Wang M, et al
    GPR37 promotes colorectal cancer liver metastases by enhancing the glycolysis and histone lactylation via Hippo pathway.
    Oncogene. 2023 Sep 25. doi: 10.1038/s41388-023-02841.
    >> Share

  56. YU A, Yu P, Zhu Y, Zhu R, et al
    Glucose-induced and ChREBP: MLX-mediated lipogenic program promotes hepatocellular carcinoma development.
    Oncogene. 2023 Sep 9. doi: 10.1038/s41388-023-02831.
    >> Share

  57. DU D, Qin M, Shi L, Liu C, et al
    RNA binding motif protein 45-mediated phosphorylation enhances protein stability of ASCT2 to promote hepatocellular carcinoma progression.
    Oncogene. 2023 Sep 1. doi: 10.1038/s41388-023-02795.
    >> Share

  58. QIAO X, Lin J, Shen J, Chen Y, et al
    FBXO28 suppresses liver cancer invasion and metastasis by promoting PKA-dependent SNAI2 degradation.
    Oncogene. 2023;42:2878-2891.
    >> Share


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