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Articles published in
Proc Natl Acad Sci U S A
    June 2026
  1. RIVERA-LUGO R, Garcia Castillo J, Lobanovska M, Tang E, et al
    Avoidance of MAIT cells is an essential determinant of Listeria monocytogenes pathogenesis.
    Proc Natl Acad Sci U S A. 2026;123:e2601925123.
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  2. WU X, Jin L, Wang Q, Wang R, et al
    TadA-mediated A-to-I mRNA editing rewires redox metabolism to promote dominance of epidemic Klebsiella pneumoniae clones.
    Proc Natl Acad Sci U S A. 2026;123:e2536397123.
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  3. HSIEH YP
    Potassium controls skin adaptation in Candida auris.
    Proc Natl Acad Sci U S A. 2026;123:e2611972123.
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  4. ANAYA-SANCHEZ A, Ragunathan PT, Hung A, Van Alst AJ, et al
    Host methylglyoxal activates the Listeria virulence program, allowing bacteria to evade inflammatory phagocytes by cell-to-cell spread.
    Proc Natl Acad Sci U S A. 2026;123:e2534912123.
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  5. TARIQUE AA, Emming S, Kelk D, Logan J, et al
    Multiple defects in macrophage antibacterial responses support intracellular survival of Mycobacterium abscessus in cystic fibrosis.
    Proc Natl Acad Sci U S A. 2026;123:e2537320123.
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  6. BIAN Z, Wilhoit K, Liber J, Peer A, et al
    Meiosis-specific genes play roles in ploidy reduction in Cryptococcus neoformans titan cells.
    Proc Natl Acad Sci U S A. 2026;123:e2522069123.
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    May 2026
  7. WURSTER S, Pantaleon Garcia J, Wang Y, Albert ND, et al
    Early adjunct anti-PD-L1 immunotherapy improves outcomes and restores infection-induced immune paralysis in mice with invasive pulmonary mucormycosis.
    Proc Natl Acad Sci U S A. 2026;123:e2512042123.
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  8. DOOKIE R, Narciso AR, Gaytan MO, Narayana Moorthy A, et al
    Pneumococcal membrane particles promote serotype-independent cellular and humoral immunity and protect against pneumococcal colonization.
    Proc Natl Acad Sci U S A. 2026;123:e2537226123.
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  9. COHEN BLM, Croke K, Hanage WP, Cohen T, et al
    Migration-linked TB epidemics: How TB elimination in high-income countries depends on the success of TB control in high-burden settings.
    Proc Natl Acad Sci U S A. 2026;123:e2611864123.
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  10. GAYTAN MO, Dookie RS, Chakraborty S, Narayana Moorthy A, et al
    Identification of immunostimulatory antigens in Group A Streptococcus-derived vesicles.
    Proc Natl Acad Sci U S A. 2026;123:e2537351123.
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  11. COMANI VB, De Bei O, Paris G, Marchetti M, et al
    Refining the mechanism of heme acquisition from free hemoglobin by Staphylococcus aureus IsdH.
    Proc Natl Acad Sci U S A. 2026;123:e2601134123.
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  12. WANG Y, Han X, Wang L, Wang J, et al
    TLR1 deficiency associates with immune dysregulation and colitis.
    Proc Natl Acad Sci U S A. 2026;123:e2517429123.
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    April 2026
  13. GREEN ER, Negretti NM, Brunner TH, Shealy NG, et al
    The intestinal microbiota impacts nutritional immunity and resistance to Acinetobacter baumannii pneumonia.
    Proc Natl Acad Sci U S A. 2026;123:e2534432123.
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  14. COLOMER-WINTER C, Nair ZJ, Chua JYJ, Jabli S, et al
    A two-component system signaling hub controls enterococcal membrane remodeling in response to daptomycin.
    Proc Natl Acad Sci U S A. 2026;123:e2532437123.
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  15. WEI Z, Li C, Song F, Zhang X, et al
    A farnesol-sensing triad in Pseudomonas aeruginosa drives interkingdom predation on Candida albicans via signal transduction.
    Proc Natl Acad Sci U S A. 2026;123:e2529531123.
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  16. MEDINA D, Martins RA, Prist PR, Buttimer S, et al
    Connecting habitats, boosting disease resistance: Spatial connectivity enhances amphibian microbiome defenses against fungal pathogen.
    Proc Natl Acad Sci U S A. 2026;123:e2520745123.
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  17. GARO LP, Brueck K, Walachowski S, Jayaraman A, et al
    Proton-activated chloride channel 1 is essential for innate host defense against bacterial sepsis.
    Proc Natl Acad Sci U S A. 2026;123:e2515768123.
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    March 2026
  18. LIPMAN DJ
    Genomic epidemiology of Salmonella and Campylobacter in poultry production: Quantifying the contribution of primary breeders.
    Proc Natl Acad Sci U S A. 2026;123:e2536554123.
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  19. JO J, Upadhyay T, You X, Bennett JM, et al
    Unique structural and ligand-binding properties of the Staphylococcus aureus serine hydrolase FphE.
    Proc Natl Acad Sci U S A. 2026;123:e2532683123.
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  20. IM HN, Lee Y, Song Y, Hahn H, et al
    Structural insights into SetA-mediated Rab1 glucosylation and PI3P-guided localization during early Legionella infection.
    Proc Natl Acad Sci U S A. 2026;123:e2535016123.
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  21. ADDINGTON E, Wale KR, Horsburgh E, Fargeas M, et al
    Catabolism of serine enantiomers represses enterohemorrhagic Escherichia coli virulence factors via modulation of the nitrogen stress response.
    Proc Natl Acad Sci U S A. 2026;123:e2532916123.
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  22. DONG Y, Ji X, Dong T, Wang Y, et al
    Reprogrammed SimCells for antimicrobial therapy.
    Proc Natl Acad Sci U S A. 2026;123:e2517118123.
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  23. LIEW JH, Norman A, Illouz M, Teo TH, et al
    Smooth-to-rough morphotype switching, a mechanism of phage resistance in Mycobacterium abscessus.
    Proc Natl Acad Sci U S A. 2026;123:e2531197123.
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  24. DODD PJ, Horton KC
    A global analysis of patterns of tuberculosis exposure and transmission.
    Proc Natl Acad Sci U S A. 2026;123:e2526321123.
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    February 2026
  25. AGARWAL H, Ben H, Chaini A, Gurnani B, et al
    beta(2)-microglobulin inhibits Escherichia coli biofilm formation via selectively blocking curli assembly.
    Proc Natl Acad Sci U S A. 2026;123:e2515986123.
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  26. JOHNSON JE, Agrawal K, Al-Lamki RS, Zhang F, et al
    T cell receptors for antigen on intraepithelial cytolytic T lymphocytes in celiac disease engage enterocyte HLA-E and HLA-B.
    Proc Natl Acad Sci U S A. 2026;123:e2525433123.
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    January 2026
  27. KATHARIOS-LANWERMEYER S, Zarrella TM, Godsil M, Severin S, et al
    A quorum-sensing molecule from Pseudomonas aeruginosa induces defensive multicellularity in a coinfecting pathogen.
    Proc Natl Acad Sci U S A. 2026;123:e2513122123.
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  28. MCDONOUGH LD, Li S, Munsamy-Govender V, Gwin CM, et al
    An activator of a two-component system controls cell separation and intrinsic drug resistance in Mycobacterium tuberculosis.
    Proc Natl Acad Sci U S A. 2026;123:e2519608123.
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  29. VELEZ AZ, Radin JN, Kennedy EN, Parsons JB, et al
    The innate immune protein calprotectin ablates the bactericidal activity of beta-lactam antibiotics.
    Proc Natl Acad Sci U S A. 2026;123:e2513462123.
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  30. TURCOTTE EA, Kim K, Eislmayr KD, Goers L, et al
    Shigella OspF blocks rapid p38-dependent priming of the NAIP-NLRC4 inflammasome.
    Proc Natl Acad Sci U S A. 2026;123:e2510950123.
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  31. TONELLI BA, Youngflesh C, Tingley MW
    An ecological cascade links climatic variability to avian irruptions and zoonotic salmonellosis outbreaks.
    Proc Natl Acad Sci U S A. 2026;123:e2511209123.
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  32. GAO J, Xu W, Zhou Z, Lu L, et al
    Legionella effector Ceg10 acetylates RPS20 to inhibit host translation and induce cell cycle arrest.
    Proc Natl Acad Sci U S A. 2026;123:e2517995123.
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  33. HERNANDEZ-BIRD J, He B, VanOtterloo LM, Billings EB, et al
    Resistance, heteroresistance, and fitness costs drive colistin treatment failure during Acinetobacter baumannii pneumonia.
    Proc Natl Acad Sci U S A. 2026;123:e2515303123.
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    December 2025
  34. NIELSEN BF, Park SW, Howerton E, Lorentzen OF, et al
    Complex multiannual cycles of Mycoplasma pneumoniae: Persistence and the role of stochasticity.
    Proc Natl Acad Sci U S A. 2025;122:e2509184122.
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  35. BANERJEE A, Pickelner S, Smith F, Tenuta LMA, et al
    Fluoride triggers lysis in Streptococcus mutans by inhibition of the Clp protease complex, leading to an unabated competence cascade.
    Proc Natl Acad Sci U S A. 2025;122:e2511884122.
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  36. JANET-MAITRE M, Di Venanzio G, Jackson-Litteken CD, Scott NE, et al
    Intracellular Acinetobacter baumannii acts as a transient reservoir in lung infection via a "persist and resist" strategy.
    Proc Natl Acad Sci U S A. 2025;122:e2511369122.
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  37. TRAN PM, Anaya-Sanchez A, Ji DX, Schwarz MCR, et al
    Cell envelope maintenance by PhoP is essential for Mycobacterium tuberculosis methylglyoxal resistance.
    Proc Natl Acad Sci U S A. 2025;122:e2523024122.
    >> Share

  38. ESTEVES NC, Tao R, Pu Q, Banerjee A, et al
    Nitric oxide promotes rapid development of motility to accelerate biofilm dispersal in Vibrio cholerae.
    Proc Natl Acad Sci U S A. 2025;122:e2526864122.
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  39. ANGELES-SOLANO M, Tabashsum Z, Liu JD, Lifschin ZJ, et al
    Antibiotics accumulate in Klebsiella pneumoniae liver abscesses but fail to eliminate antibiotic-tolerant populations.
    Proc Natl Acad Sci U S A. 2025;122:e2524436122.
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    November 2025
  40. LIYAYI IK, Bera AK, Perera YR, Ferdausi N, et al
    A periplasmic zinc capture protein enhances the resistance of Neisseria gonorrhoeae to nutritional immunity.
    Proc Natl Acad Sci U S A. 2025;122:e2426176122.
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  41. KAPITAN M, Niemiec MJ, Millet N, Brandt P, et al
    Synergistic interactions between Candida albicans and Enterococcus faecalis promote toxin-dependent host cell damage.
    Proc Natl Acad Sci U S A. 2025;122:e2505310122.
    >> Share

  42. SONG C, Sun L, Wang J, Liu S, et al
    ENKD1 attenuates antibacterial immunity by facilitating TRIM21-mediated RUBCN degradation to suppress LC3-associated phagocytosis.
    Proc Natl Acad Sci U S A. 2025;122:e2501953122.
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  43. TATARA AM, Lightbown S, Kang S, Jung WH, et al
    Scaffold vaccination for prevention of orthopedic device infection.
    Proc Natl Acad Sci U S A. 2025;122:e2409562122.
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  44. BRODY SM, Kalinka E, Prostak SM, Carvalho T, et al
    Homology-mediated transformation of frog-killing fungus Batrachochytrium dendrobatidis illuminates chytrid development and pathogenesis.
    Proc Natl Acad Sci U S A. 2025;122:e2507572122.
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    October 2025
  45. DANCHUK SN, Duffy SC, Sullivan J, Beenish Rufai S, et al
    Virulence hierarchies within the Mycobacterium tuberculosis complex.
    Proc Natl Acad Sci U S A. 2025;122:e2507104122.
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  46. SUN S, Bian Z, Xu Z, Choi Y, et al
    Unisexual reproduction in the global human fungal pathogen Cryptococcus neoformans.
    Proc Natl Acad Sci U S A. 2025;122:e2521779122.
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  47. ROSS BN, Evans E, Diggle F, Briaud P, et al
    The role of colony morphotype in shaping gene essentiality in Mycobacteroides abscessus.
    Proc Natl Acad Sci U S A. 2025;122:e2500719122.
    >> Share

  48. BERRYHILL BA, Gil-Gil T, Witzany C, Goldberg DA, et al
    The role of innate immunity, antibiotics, and bacteriophages in the course of bacterial infections and their treatment.
    Proc Natl Acad Sci U S A. 2025;122:e2507914122.
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    September 2025
  49. FOUNTAIN AJ, Bohning J, McLaughlin SH, Morgan TE, et al
    Structural and functional analysis of the Mycobacterium tuberculosis MmpS5L5 efflux pump presages increased bedaquiline resistance.
    Proc Natl Acad Sci U S A. 2025;122:e2516660122.
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  50. RAGOTTE RJ, Liang H, Tam J, Miletic S, et al
    De novo design of potent inhibitors of clostridial family toxins.
    Proc Natl Acad Sci U S A. 2025;122:e2509329122.
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  51. LE MOUELLIC W, Levillain F, Wu TD, Caouaille M, et al
    Inorganic sulfate is critical for Mycobacterium tuberculosis lung tissue colonization and redox balance.
    Proc Natl Acad Sci U S A. 2025;122:e2503966122.
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  52. CARD KJ, Crozier D, Durmaz A, Gray J, et al
    Evolution under vancomycin selection drives divergent collateral sensitivity patterns in Staphylococcus aureus.
    Proc Natl Acad Sci U S A. 2025;122:e2507962122.
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  53. REUBER EE, Hickey E, Pradhan A, Sprute R, et al
    Glycan microarray analysis of Candida-related antibodies in human and mice sera guides biomarker discovery and vaccine development.
    Proc Natl Acad Sci U S A. 2025;122:e2505340122.
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  54. KOLESKE B, Rajagopalan S, Schill C, Lun S, et al
    Loss of the ESX-5 secretion locus in Mycobacterium tuberculosis reshapes the mycomembrane and enhances ESX-1 substrate secretion.
    Proc Natl Acad Sci U S A. 2025;122:e2509997122.
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  55. WANG ER, Cho K, Harrison GA, Smelyansky SR, et al
    Metabolic rewiring of isoniazid sensitivity in Mycobacterium tuberculosis.
    Proc Natl Acad Sci U S A. 2025;122:e2421336122.
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    August 2025
  56. BRUMFIELD KD, Usmani M, Long DM, Lupari HA, et al
    Climate change and Vibrio: Environmental determinants for predictive risk assessment.
    Proc Natl Acad Sci U S A. 2025;122:e2420423122.
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  57. JAISHANKAR J, Yang H, O'Keefe IP, Tenaglia BM, et al
    A critical role for Vibrio parahaemolyticus LPS to mediate evasion of host immune response during infection.
    Proc Natl Acad Sci U S A. 2025;122:e2426547122.
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  58. OIDE H, Kubori T, Nagai H, Nozawa T, et al
    Phosphatidic acid production on the vacuole harboring Legionella pneumophila is a signal for recognition of interferon-induced GTPases.
    Proc Natl Acad Sci U S A. 2025;122:e2420096122.
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  59. LUO G, Wen Y, Wang M, Wang H, et al
    A granulin-positive macrophage subtype in mycobacterial granulomas alleviates tissue damage by limiting excessive inflammation.
    Proc Natl Acad Sci U S A. 2025;122:e2413946122.
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    July 2025
  60. RIDELFI M, Vezzani G, Roscioli E, Batani G, et al
    A multifunctional anti-O-Antigen human monoclonal antibody protects against Shigella sonnei infection in vivo.
    Proc Natl Acad Sci U S A. 2025;122:e2426211122.
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  61. DUNCAN RP, Scheele BC, Clulow S
    Thermal mismatch models derived from occurrence data predict pathogen prevalence in frogs.
    Proc Natl Acad Sci U S A. 2025;122:e2423706122.
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  62. JONES BS, Pareek V, Hu DD, Weaver SD, et al
    N-acetyltransferases required for iron uptake and aminoglycoside resistance promote virulence lipid production in Mycobacterium marinum.
    Proc Natl Acad Sci U S A. 2025;122:e2502577122.
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  63. LIU B, Su Y, Sun H, Yang B, et al
    Vamp3/syntaxin 4 mediates the basolateral membrane fusion of TfR transcytosis across the BBB and is exploited by pathogenic E. coli.
    Proc Natl Acad Sci U S A. 2025;122:e2500285122.
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  64. CHAUHAN K, Datta D, Kapoor Y, Passricha N, et al
    A Mycobacterium tuberculosis secreted virulence factor Rv1435c/hsr1 disrupts host snRNP biogenesis.
    Proc Natl Acad Sci U S A. 2025;122:e2423349122.
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  65. Retraction for Ruby and Novick, Plasmid interactions in Staphylococcus aureus: Nonadditivity of compatible plasmid DNA pools.
    Proc Natl Acad Sci U S A. 2025;122:e2515266122.
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  66. VATARECK E, Rick T, Oswaldo Gomez N, Bandyopadhyay A, et al
    Epigenetic cellular memory in Pseudomonas aeruginosa generates phenotypic variation in response to host environments.
    Proc Natl Acad Sci U S A. 2025;122:e2415345122.
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  67. PARK Y, Sisley TA, Stone MC, Corrigan RM, et al
    SpbR controls lipoteichoic acid length by directly inhibiting signal peptidase SpsB in Staphylococcus aureus.
    Proc Natl Acad Sci U S A. 2025;122:e2426464122.
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  68. KOCHANOWSKY JA, Betts EL, Encinas G, Amoah J, et al
    Trichomonas vaginalis extracellular vesicles suppress IFNepsilon-mediated responses driven by its intracellular bacterial symbiont Mycoplasma hominis.
    Proc Natl Acad Sci U S A. 2025;122:e2508297122.
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    June 2025
  69. KUHN HW, Smither MR, Jin RJ, Collins CA, et al
    LDL receptor-mediated endocytosis of Escherichia coli alpha-hemolysin mediates renal epithelial toxicity.
    Proc Natl Acad Sci U S A. 2025;122:e2505482122.
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  70. RASOAMALALA F, Ramasindrazana B, Parany MJ, Rahajandraibe S, et al
    Unraveling the role of rat and flea population dynamics on the seasonality of plague epidemics in Madagascar.
    Proc Natl Acad Sci U S A. 2025;122:e2502161122.
    >> Share

  71. DAS L, Chen B, Rajagopalan S, Vilcheze C, et al
    Mycobacteriophage-mediated gene transfer enables in vitro drug screening and in vivo tracking of Mycobacterium leprae.
    Proc Natl Acad Sci U S A. 2025;122:e2508271122.
    >> Share

  72. COLQUHOUN JM, Brzezinski CU, Ji A, Marotta J, et al
    Repurposing a drug to punish carbapenem-resistant Acinetobacter baumannii.
    Proc Natl Acad Sci U S A. 2025;122:e2423650122.
    >> Share

  73. ZHANG Y, Xiao G, Ding H, Zou Q, et al
    Direct sensing of host ferric iron by an archetype histidine kinase mediates virulence of an enteric pathogen.
    Proc Natl Acad Sci U S A. 2025;122:e2507874122.
    >> Share

  74. PEARSON T, Furstenau T, Wood C, Rigas V, et al
    Population sequencing for phylogenetic diversity and transmission analyses.
    Proc Natl Acad Sci U S A. 2025;122:e2424797122.
    >> Share

  75. LOPEZ-PEREZ M, Balasubramanian D, Campos-Lopez A, Crist C, et al
    Allelic variations and gene cluster modularity act as nonlinear bottlenecks for cholera emergence.
    Proc Natl Acad Sci U S A. 2025;122:e2417915122.
    >> Share

  76. WINSOR NJ, Tsang DK, Ranger A, Singh O, et al
    The IL-18 receptor is expressed on murine small-intestinal enterochromaffin cells and executes a recovery program upon injury.
    Proc Natl Acad Sci U S A. 2025;122:e2417149122.
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  77. XING Y, Hernandez Santos HJ, Qiu L, Ritter SR, et al
    Phage-induced protection against lethal bacterial reinfection.
    Proc Natl Acad Sci U S A. 2025;122:e2423286122.
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    May 2025
  78. PETTYGROVE BA, Nygaard TK, Borgogna TR, Malachowa N, et al
    Staphylococcus aureus SaeR/S-regulated factors overcome human complement-mediated inhibition of aggregation to evade neutrophil killing.
    Proc Natl Acad Sci U S A. 2025;122:e2412447122.
    >> Share

  79. YANG B, Rutkowski N, Ruta A, Gray-Gaillard E, et al
    Murine gut microbiota dysbiosis via enteric infection modulates the foreign body response to a distal biomaterial implant.
    Proc Natl Acad Sci U S A. 2025;122:e2422169122.
    >> Share

  80. SANTAMARIA C, Biegas KJ, Lim PN, Cabral J, et al
    Trehalose dimycolate inhibits phagosome maturation and promotes intracellular M. tuberculosis growth via noncanonical SNARE interactions.
    Proc Natl Acad Sci U S A. 2025;122:e2423292122.
    >> Share

  81. ROSSEN ND, Touhara KK, Castro J, Harrington AM, et al
    Population imaging of enterochromaffin cell activity reveals regulation by somatostatin.
    Proc Natl Acad Sci U S A. 2025;122:e2501525122.
    >> Share

  82. DARTOIS V, Lan T, Ganapathy US, Wong CF, et al
    Next-generation rifamycins for the treatment of mycobacterial infections.
    Proc Natl Acad Sci U S A. 2025;122:e2423842122.
    >> Share

  83. KAWAGISHI Y, Murase K, Grebenshchikova A, Iibushi J, et al
    Bacterial extracellular vesicles target different bacterial species, impairing cell division and diminishing their pathogenicity.
    Proc Natl Acad Sci U S A. 2025;122:e2416652122.
    >> Share

    April 2025
  84. FOUNTAIN AJ, Waller NJE, Cheung CY, Jowsey W, et al
    Verapamil and its metabolite norverapamil inhibit the Mycobacterium tuberculosis MmpS5L5 efflux pump to increase bedaquiline activity.
    Proc Natl Acad Sci U S A. 2025;122:e2426827122.
    >> Share

  85. AMBROGI M, Hernandez LL, Strand DW, Kumar S, et al
    A 5-HT-mediated urethral defense against urinary tract infections.
    Proc Natl Acad Sci U S A. 2025;122:e2409754122.
    >> Share

  86. ARAKAWA M, Uriu K, Saito K, Hirose M, et al
    HEATR3 recognizes membrane rupture and facilitates xenophagy in response to Salmonella invasion.
    Proc Natl Acad Sci U S A. 2025;122:e2420544122.
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  87. Correction for Quach et al., Deep learning-driven bacterial cytological profiling to determine antimicrobial mechanisms in Mycobacterium tuberculosis.
    Proc Natl Acad Sci U S A. 2025;122:e2504475122.
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    March 2025
  88. MYCHACK A, Evans D, Gilles T, James MJ, et al
    Staphylococcus aureus uses a GGDEF protein to recruit diacylglycerol kinase to the membrane for lipid recycling.
    Proc Natl Acad Sci U S A. 2025;122:e2414696122.
    >> Share

  89. YANG Z, Zhang L, Ottavi S, Geri JB, et al
    ACOD1-mediated lysosomal membrane permeabilization contributes to Mycobacterium tuberculosis-induced macrophage death.
    Proc Natl Acad Sci U S A. 2025;122:e2425309122.
    >> Share

  90. LIM J, Van AB, Koprowski K, Wester M, et al
    Amplification-free, OR-gated CRISPR-Cascade reaction for pathogen detection in blood samples.
    Proc Natl Acad Sci U S A. 2025;122:e2420166122.
    >> Share

  91. MISHRA S, Singh PR, Hu X, Lopez-Quezada L, et al
    Candidate transmission survival genome of Mycobacterium tuberculosis.
    Proc Natl Acad Sci U S A. 2025;122:e2425981122.
    >> Share

  92. SAHA S, Roy S, Hazra A, Das D, et al
    S-nitrosylation-triggered secretion of mycobacterial PknG leads to phosphorylation of SODD to prevent apoptosis of infected macrophages.
    Proc Natl Acad Sci U S A. 2025;122:e2404106122.
    >> Share

  93. OLUOCH PO, Koh EI, Proulx MK, Reames CJ, et al
    Chemical genetic interactions elucidate pathways controlling tuberculosis antibiotic efficacy during infection.
    Proc Natl Acad Sci U S A. 2025;122:e2417525122.
    >> Share

    February 2025
  94. PERAULT AI, John AS, DuMont AL, Shopsin B, et al
    Enterobacter hormaechei replaces virulence with carbapenem resistance via porin loss.
    Proc Natl Acad Sci U S A. 2025;122:e2414315122.
    >> Share

  95. LU Z, Zhang Y, Zhong Y, Qiang L, et al
    A bacterial effector manipulates host lysosomal protease activity-dependent plasticity in cell death modalities to facilitate infection.
    Proc Natl Acad Sci U S A. 2025;122:e2406715122.
    >> Share

  96. ZHANG B, Orning P, Lehman JW, Dinis A, et al
    Raver1 links Ripk1 RNA splicing to caspase-8-mediated pyroptotic cell death, inflammation, and pathogen resistance.
    Proc Natl Acad Sci U S A. 2025;122:e2420802122.
    >> Share

  97. LI Y, Pham T, Hipsher K, Lee CWJ, et al
    Identification of a protective antigen reveals the trade-off between iron acquisition and antigen exposure in a global fungal pathogen.
    Proc Natl Acad Sci U S A. 2025;122:e2420898122.
    >> Share

  98. WYLLIE RM, Jensen PA
    The MutRS quorum-sensing system controls lantibiotic mutacin production in the human pathogen Streptococcus mutans.
    Proc Natl Acad Sci U S A. 2025;122:e2421164122.
    >> Share

  99. CREMIN M, Ramirez VT, Sanchez K, Tay E, et al
    Substance P receptor signaling contributes to host maladaptive responses during enteric bacterial infection.
    Proc Natl Acad Sci U S A. 2025;122:e2415287122.
    >> Share

  100. TEPEKULE B, Barcik W, Staiger WI, Bergada-Pijuan J, et al
    Computational and in vitro evaluation of probiotic treatments for nasal Staphylococcus aureus decolonization.
    Proc Natl Acad Sci U S A. 2025;122:e2412742122.
    >> Share

  101. QUACH D, Sharp M, Ahmed S, Ames L, et al
    Deep learning-driven bacterial cytological profiling to determine antimicrobial mechanisms in Mycobacterium tuberculosis.
    Proc Natl Acad Sci U S A. 2025;122:e2419813122.
    >> Share

  102. ZHANG M, Zhao Y, Cui H, Huang W, et al
    CO(2) potentiates echinocandin efficacy during invasive candidiasis therapy via dephosphorylation of Hsp90 by Ptc2 in condensates.
    Proc Natl Acad Sci U S A. 2025;122:e2417721122.
    >> Share

    January 2025
  103. PRIYA M, Gupta SK, Koundal A, Kapoor S, et al
    Itaconate mechanism of action and dissimilation in Mycobacterium tuberculosis.
    Proc Natl Acad Sci U S A. 2025;122:e2423114122.
    >> Share

  104. SCHLOSSER S, Ullrich AL, Modares NF, Schmitz MA, et al
    Salmonella infection accelerates postnatal maturation of the intestinal epithelium.
    Proc Natl Acad Sci U S A. 2025;122:e2403344122.
    >> Share

    December 2024
  105. GAO H, Wei X, Li K, Cao Y, et al
    Cold-blooded vertebrate utilizes behavioral fever to alleviate T cell apoptosis and optimize antimicrobial immunity.
    Proc Natl Acad Sci U S A. 2024;121:e2408969121.
    >> Share

  106. SYED AK, Baral R, Van Vlack ER, Gil-Marques ML, et al
    Biofilm formation by Staphylococcus aureus is triggered by a drop in the levels of a cyclic dinucleotide.
    Proc Natl Acad Sci U S A. 2024;121:e2417323121.
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  107. DAI L, Wu Z, Sahin O, Zhao S, et al
    Mutation-based mechanism and evolution of the potent multidrug efflux pump RE-CmeABC in Campylobacter.
    Proc Natl Acad Sci U S A. 2024;121:e2415823121.
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  108. LI Y, Bel S, Benjamin JL, Ruhn KA, et al
    BCL2 regulates antibacterial autophagy in the intestinal epithelium.
    Proc Natl Acad Sci U S A. 2024;121:e2410205121.
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  109. KAHNE SC, Yoo JH, Chen J, Nakedi K, et al
    Identification of a depupylation regulator for an essential enzyme in Mycobacterium tuberculosis.
    Proc Natl Acad Sci U S A. 2024;121:e2407239121.
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    November 2024
  110. KASHYAP MP, Mishra B, Sinha R, Jin L, et al
    CD2 expressing innate lymphoid and T cells are critical effectors of immunopathogenesis in hidradenitis suppurativa.
    Proc Natl Acad Sci U S A. 2024;121:e2409274121.
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  111. ANGABO S, Pandi K, David K, Steinmetz O, et al
    CD47 and thrombospondin-1 contribute to immune evasion by Porphyromonas gingivalis.
    Proc Natl Acad Sci U S A. 2024;121:e2405534121.
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  112. RADLINSKI LC, Rogers AWL, Bechtold L, Masson HLP, et al
    Salmonella virulence factors induce amino acid malabsorption in the ileum to promote ecosystem invasion of the large intestine.
    Proc Natl Acad Sci U S A. 2024;121:e2417232121.
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  113. ZHANG Y, McWhorter KL, Rosen PC, Klaus JR, et al
    Combatting melioidosis with chemical synthetic lethality.
    Proc Natl Acad Sci U S A. 2024;121:e2406771121.
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  114. MARSHALL EKP, Nunes C, Burbaud S, Vincent CM, et al
    Microbial metabolism disrupts cytokine activity to impact host immune response.
    Proc Natl Acad Sci U S A. 2024;121:e2405719121.
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  115. DEBANDE L, Sabbah A, Kuhn L, Ngondo RP, et al
    SPATEs promote the survival of Shigella to the plasma complement system upon local hemorrhage and bacteremia.
    Proc Natl Acad Sci U S A. 2024;121:e2319951121.
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  116. FACHI JL, Oliveira S, Gilfillan S, Antonova AU, et al
    NKp46(+) ILC3s promote early neutrophil defense against Clostridioides difficile infection through GM-CSF secretion.
    Proc Natl Acad Sci U S A. 2024;121:e2416182121.
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    October 2024
  117. LI D, Zhang X, Yao Y, Sun X, et al
    Structure and function of Mycobacterium tuberculosis EfpA as a lipid transporter and its inhibition by BRD-8000.3.
    Proc Natl Acad Sci U S A. 2024;121:e2412653121.
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  118. YANG YH, Xie KF, Yang S, Wang H, et al
    BLNK negatively regulates innate antifungal immunity through inhibiting c-Cbl-mediated macrophage migration.
    Proc Natl Acad Sci U S A. 2024;121:e2400920121.
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  119. RYCROFT JA, Giorgio RT, Sargen M, Helaine S, et al
    Tracking the progeny of bacterial persisters using a CRISPR-based genomic recorder.
    Proc Natl Acad Sci U S A. 2024;121:e2405983121.
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  120. MA Q, Li J, Yu S, Zhou J, et al
    YkuR functions as a protein deacetylase in Streptococcus mutans.
    Proc Natl Acad Sci U S A. 2024;121:e2407820121.
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  121. ABHIMANYU, Longlax SC, Nishiguchi T, Ladki M, et al
    TCA metabolism regulates DNA hypermethylation in LPS and Mycobacterium tuberculosis-induced immune tolerance.
    Proc Natl Acad Sci U S A. 2024;121:e2404841121.
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    September 2024
  122. LOPATTO EDB, Pinkner JS, Sanick DA, Potter RF, et al
    Conformational ensembles in Klebsiella pneumoniae FimH impact uropathogenesis.
    Proc Natl Acad Sci U S A. 2024;121:e2409655121.
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  123. SHEIKH A, Ganguli D, Vickers TJ, Singer BB, et al
    Host-derived CEACAM-laden vesicles engage enterotoxigenic Escherichia coli for elimination and toxin neutralization.
    Proc Natl Acad Sci U S A. 2024;121:e2410679121.
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  124. LOY CJ, Servellita V, Sotomayor-Gonzalez A, Bliss A, et al
    Plasma cell-free RNA signatures of inflammatory syndromes in children.
    Proc Natl Acad Sci U S A. 2024;121:e2403897121.
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  125. PELAYO P, Hussain FA, Werlang CA, Wu CM, et al
    Prevotella are major contributors of sialidases in the human vaginal microbiome.
    Proc Natl Acad Sci U S A. 2024;121:e2400341121.
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  126. WANG X, Dou Y, Hu J, Chan CH, et al
    Conserved moonlighting protein pyruvate dehydrogenase induces robust protection against Staphylococcus aureus infection.
    Proc Natl Acad Sci U S A. 2024;121:e2321939121.
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    August 2024
  127. SONG S, Yang S, Zheng R, Yin D, et al
    Adaptive evolution of carbapenem-resistant hypervirulent Klebsiella pneumoniae in the urinary tract of a single patient.
    Proc Natl Acad Sci U S A. 2024;121:e2400446121.
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  128. GUAN J, Tang L, Wang Y, Fu M, et al
    Microsporidian EnP1 alters host cell H2B monoubiquitination and prevents ferroptosis facilitating microsporidia survival.
    Proc Natl Acad Sci U S A. 2024;121:e2400657121.
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  129. HANSEN KH, Byeon CH, Liu Q, Drace T, et al
    Structure of biofilm-forming functional amyloid PSMalpha1 from Staphylococcus aureus.
    Proc Natl Acad Sci U S A. 2024;121:e2406775121.
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  130. HARMAN-MCKENNA VK, Eshraghisamani R, Shafer N, De Buck J, et al
    Lining the small intestine with mycobacteriophages protects from Mycobacterium avium subsp. paratuberculosis and eliminates fecal shedding.
    Proc Natl Acad Sci U S A. 2024;121:e2318627121.
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  131. DUNCAN RP, Moustafa DA, Lewin GR, Diggle FL, et al
    Improvement of a mouse infection model to capture Pseudomonas aeruginosa chronic physiology in cystic fibrosis.
    Proc Natl Acad Sci U S A. 2024;121:e2406234121.
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    July 2024
  132. SCHWARTZ L, Simoni A, Yan P, Salamon K, et al
    Insulin receptor orchestrates kidney antibacterial defenses.
    Proc Natl Acad Sci U S A. 2024;121:e2400666121.
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  133. KUNKLE DE, Cai Y, Eichman BF, Skaar EP, et al
    An interstrand DNA crosslink glycosylase aids Acinetobacter baumannii pathogenesis.
    Proc Natl Acad Sci U S A. 2024;121:e2402422121.
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  134. Correction for Rengarajan et al., Mycobacterium tuberculosis Rv2224c modulates innate immune responses.
    Proc Natl Acad Sci U S A. 2024;121:e2410437121.
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    June 2024
  135. PEREZ AJ, Lamanna MM, Bruce KE, Touraev MA, et al
    Elongasome core proteins and class A PBP1a display zonal, processive movement at the midcell of Streptococcus pneumoniae.
    Proc Natl Acad Sci U S A. 2024;121:e2401831121.
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  136. OGUNLADE B, Tadesse LF, Li H, Vu N, et al
    Rapid, antibiotic incubation-free determination of tuberculosis drug resistance using machine learning and Raman spectroscopy.
    Proc Natl Acad Sci U S A. 2024;121:e2315670121.
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  137. HERRERA A, Packer MM, Rosas-Lemus M, Minasov G, et al
    Vibrio MARTX toxin processing and degradation of cellular Rab GTPases by the cytotoxic effector Makes Caterpillars Floppy.
    Proc Natl Acad Sci U S A. 2024;121:e2316143121.
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  138. COHEN SB, Urdahl KB
    Weaponizing the bystander T cell army to fight tuberculosis.
    Proc Natl Acad Sci U S A. 2024;121:e2407559121.
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  139. NEBO ID, Frew JW, Gudjonsson JE, Petukhova L, et al
    Tissue comparability and bias in hidradenitis suppurativa transcriptomic studies.
    Proc Natl Acad Sci U S A. 2024;121:e2404503121.
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  140. JIN L, Kashyap MP, Haque ST, Li C, et al
    Reply to Nebo et al.: Pathogenesis of advanced hidradenitis suppurativa: Are there differences based on anatomical location, gender, and race?
    Proc Natl Acad Sci U S A. 2024;121:e2405298121.
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    May 2024
  141. ROWEKAMP I, Maschirow L, Rabes A, Fiocca Vernengo F, et al
    IL-33 controls IL-22-dependent antibacterial defense by modulating the microbiota.
    Proc Natl Acad Sci U S A. 2024;121:e2310864121.
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  142. GAO L, Tian T, Xiong T, Zhang X, et al
    Type VII secretion system extracellular protein B targets STING to evade host anti-Staphylococcus aureus immunity.
    Proc Natl Acad Sci U S A. 2024;121:e2402764121.
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  143. PATERSON RL, La Manna MP, Arena De Souza V, Walker A, et al
    An HLA-E-targeted TCR bispecific molecule redirects T cell immunity against Mycobacterium tuberculosis.
    Proc Natl Acad Sci U S A. 2024;121:e2318003121.
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  144. FACHI JL, Di Luccia B, Gilfillan S, Chang HW, et al
    Deficiency of IL-22-binding protein enhances the ability of the gut microbiota to protect against enteric pathogens.
    Proc Natl Acad Sci U S A. 2024;121:e2321836121.
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    April 2024
  145. IRACANE E, Arias-Sarda C, Maufrais C, Ene IV, et al
    Identification of an active RNAi pathway in Candida albicans.
    Proc Natl Acad Sci U S A. 2024;121:e2315926121.
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  146. CHEVEE V, Hullahalli K, Dailey KG, Guereca L, et al
    Temporal and spatial dynamics of Listeria monocytogenes central nervous system infection in mice.
    Proc Natl Acad Sci U S A. 2024;121:e2320311121.
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  147. DATTA M, Via LE, Dartois V, Weiner DM, et al
    Normalizing granuloma vasculature and matrix improves drug delivery and reduces bacterial burden in tuberculosis-infected rabbits.
    Proc Natl Acad Sci U S A. 2024;121:e2321336121.
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  148. FORTUNE SM
    The Titanic question in TB control: Should we worry about the bummock?
    Proc Natl Acad Sci U S A. 2024;121:e2403321121.
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    March 2024
  149. ROSAY T, Jimenez AG, Sperandio V
    Glucuronic acid confers colonization advantage to enteric pathogens.
    Proc Natl Acad Sci U S A. 2024;121:e2400226121.
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  150. KEITH M, Park de la Torriente A, Chalka A, Vallejo-Trujillo A, et al
    Predictive phage therapy for Escherichia coli urinary tract infections: Cocktail selection for therapy based on machine learning models.
    Proc Natl Acad Sci U S A. 2024;121:e2313574121.
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  151. PATTERSON B, Dinkele R, Gessner S, Koch A, et al
    Aerosolization of viable Mycobacterium tuberculosis bacilli by tuberculosis clinic attendees independent of sputum-Xpert Ultra status.
    Proc Natl Acad Sci U S A. 2024;121:e2314813121.
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  152. DAI R, Yang S, Pang T, Tian M, et al
    Identification of a negative-strand RNA virus with natural plant and fungal hosts.
    Proc Natl Acad Sci U S A. 2024;121:e2319582121.
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  153. SCHWARTZMAN JA, Lebreton F, Salamzade R, Shea T, et al
    Global diversity of enterococci and description of 18 previously unknown species.
    Proc Natl Acad Sci U S A. 2024;121:e2310852121.
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