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Articles published in
J Med Chem
    October 2026
  1. LOBANOV V, Lupien A, Vocat A, Singh R, et al
    Antivirulence Benzothiophenes Inhibit Intracellular Mycobacterium tuberculosis by Targeting the Sensor Histidine Kinase MprB.
    J Med Chem. 2026;69:23968-23990.
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  2. GAO Z, Hao W, Cui C, Chen M, et al
    Design, Synthesis, and Biological Evaluation of Novel Tetrazole-Containing Tetrahydroisoquinoline Derivatives as Putative CYP51 Inhibitors against Candida Species.
    J Med Chem. 2026;69:23810-23834.
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  3. KUSHWAHA R, Chakraborty D, Mandal A, Upadhyay A, et al
    Re(I)-BODIPY Photosensitizer for Infected Wound Healing in the Rat Model under Green Light.
    J Med Chem. 2026;69:23706-23722.
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  4. FANG J, Meng L, Hong S, Zhang J, et al
    Leveraging the Iron-Probe-MurB Interaction: An Enhanced Platform for PET Imaging of Bacterial Infections.
    J Med Chem. 2026;69:21777-21788.
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  5. LIN S, Zhang Q, Tan S, Lou L, et al
    Phenothiazine-Driven Autophagic Response in Macrophages as an Anti-cutaneous Tuberculosis Approach.
    J Med Chem. 2026;69:22355-22369.
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    September 2026
  6. FEI F, Burnside CM, Lun S, Wee D, et al
    Structural and Mechanistic Studies of ADEPs Yield Potent Antibacterials and a Drug Formulation Strategy for Tuberculosis.
    J Med Chem. 2026 Sep 1. doi: 10.1021/acs.jmedchem.6c00893.
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    August 2026
  7. MARTIN DP, Teng M, Nammalwar B, Perez C, et al
    Discovery and Optimization of Novel Nonhydroxamate LpxC Inhibitors for the Treatment of Multidrug-Resistant Gram-Negative Infections.
    J Med Chem. 2026;69:18692-18704.
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  8. ZHANG T, Zhao J, Praveen P, Parisi K, et al
    Unveiling the Potential of Magainin Derivatives against Candida Species.
    J Med Chem. 2026;69:18992-19004.
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    July 2026
  9. LUO Z, Sun Y, Gao Z, Liu N, et al
    Rational Design and Discovery of CZx-243: A Highly Stable and Orally Bioavailable Triazole CYP51 Inhibitor for the Treatment of Invasive Fungal Infections.
    J Med Chem. 2026;69:17189-17210.
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  10. LI S, Hao W, Ye Z, Mo G, et al
    Screening of Cell-Penetrating Peptides To Enhance the Therapeutic Efficacy of alpha-Helical Antimicrobial Peptides against Intracellular Bacterial Infections.
    J Med Chem. 2026;69:16455-16475.
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  11. YU Z, Li Y, Liu J, Xu Q, et al
    Novel High-Efficacy Antimicrobial Peptides Derived from Myxinidin and their Therapeutic Efficacy in Bacterial Pneumonia.
    J Med Chem. 2026;69:16997-17024.
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  12. ZHAO X, Liu H, Lin X, Fontaine J, et al
    Design of Right-Handed D-Sulfonyl-gamma-AApeptides with Broad-Spectrum Antimicrobial Activity.
    J Med Chem. 2026;69:16911-16925.
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  13. KIM YG, O'Driscoll M, Horgan C, Boya BR, et al
    Lauric Acid- and BDSF-Derived N-Acyl Sulfonamides as Potent Antibiofilm and Antivirulence Agents against Staphylococcus aureus.
    J Med Chem. 2026 Jul 9. doi: 10.1021/acs.jmedchem.6c01485.
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  14. ZHANG S, Liu Z, Zhang N, Wu S, et al
    Discovery of Guanidyl-Stapled Aurein1.2 Peptides with Potent In Vivo Antimicrobial Activities.
    J Med Chem. 2026;69:15558-15569.
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  15. TAMHAEV R, Recchia D, Zahorszka M, Stelitano G, et al
    Rational Design of Diaryl Ether-Based Dual Inhibitors Targeting Successive Essential Enzymes HadAB and InhA in Mycobacterium tuberculosis.
    J Med Chem. 2026 Jul 7. doi: 10.1021/acs.jmedchem.6c01302.
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    June 2026
  16. SUN Y, Li R, Yin K, Zhang J, et al
    Computer-Aided Rational Modification of Hst 5 Based on Ssa1/2 and the Antifungal Activity of the Derivatives against Candida spp.
    J Med Chem. 2026 Jun 22. doi: 10.1021/acs.jmedchem.5c03652.
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  17. ZHAO Z, Zhang M, Yang K, Liao X, et al
    Synthesis of Novel Isoxazoline Derivatives with Selective Inhibition of the Drug Efflux Pump Mdr1 to Reverse Drug Resistance of Candida albicans In Vitro and In Vivo.
    J Med Chem. 2026 Jun 16. doi: 10.1021/acs.jmedchem.5c03625.
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  18. DIAMANTI E, Cremers AJH, Li Y, Exapicheidou I, et al
    Targeting the Energy-Coupling Factor Transporters: A Novel Antibiotic Drug Target in Streptococcus pneumoniae.
    J Med Chem. 2026 Jun 12. doi: 10.1021/acs.jmedchem.5c03638.
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  19. MERRICK CE, Chakraborty M, Van Wazer JM, O'Connor LD, et al
    A Siderophore-Antibiotic Heterodimer Imaging Agent Enables In Vivo PET Imaging of S. aureus Infections.
    J Med Chem. 2026;69:13652-13669.
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  20. URBANOWICZ KA, Marek-Urban PH, Wrochna K, Rogalska M, et al
    C-BODIPY Dyads Based on Fused-Ring Organoboron Scaffolds for Efficient Photodynamic Therapy Targeting Candida albicans Yeast and Biofilms.
    J Med Chem. 2026 Jun 1. doi: 10.1021/acs.jmedchem.6c00280.
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    May 2026
  21. THARRA PR, Youse MS, Abutaleb NS, Abdelsattar AS, et al
    Structure-Activity Relationship Studies for 1,3,4-Thiadiazole-Based Bacterial Carbonic Anhydrase Inhibitors with In Vivo Efficacy against Drug-Resistant Neisseria gonorrhoeae.
    J Med Chem. 2026;69:12183-12204.
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  22. ZOU P, Tu J, Liu R, He Q, et al
    Discovery of New Pyrazolone Derivatives for Treating Invasive Fungal Infections by Iron Homeostasis Disruption.
    J Med Chem. 2026;69:11382-11396.
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  23. ZHOU YB, Wu X, Li YJ, Zhao SY, et al
    Discovery of Catechol-Benzothiazole Conjugates as Antibacterial Synergists against Pseudomonas aeruginosa by Inhibiting Biofilm Formation.
    J Med Chem. 2026;69:11258-11291.
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  24. SHAO H, Wu X, Cheng S, Wang B, et al
    Rhodanine-Inspired Development of Dual-Action Mycobacterium tuberculosis Protein Tyrosine Phosphatase B Inhibitors.
    J Med Chem. 2026 May 6. doi: 10.1021/acs.jmedchem.6c00103.
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    April 2026
  25. MOSALLAM N, O'Neill PM, Lisauskaite M, Woodley CM, et al
    Second-Generation Anti-Tubercular Squaramides Targeting Complex V of the Respiratory Chain of Mycobacterium tuberculosis Displaying Enhanced Metabolic Stability.
    J Med Chem. 2026 Apr 23. doi: 10.1021/acs.jmedchem.5c03274.
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  26. LIU Q, Engelhart CA, Wallach JB, Ge P, et al
    Design, Synthesis and Biological Evaluation of Potent Piperazine-Based BioA Inhibitors Targeting Biotin Biosynthesis in Mycobacterium tuberculosis.
    J Med Chem. 2026 Apr 22. doi: 10.1021/acs.jmedchem.5c03325.
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    March 2026
  27. XU T, Wang T, Hu L, Han N, et al
    Identification of Rutaecarpine-Pyridinium Quaternary Ammonium Conjugates Exhibiting Dual Mechanisms of Membrane-Targeting and DNA Topo I Inhibition as Potent Antimicrobials against Methicillin-Resistant Staphylococcus aureus.
    J Med Chem. 2026 Mar 30. doi: 10.1021/acs.jmedchem.5c03478.
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  28. KANG J, Lee D, Kim MK, Ahn JH, et al
    New Multitarget Inhibitor Potentiates Antimicrobial Activity of Aztreonam against Metallo-beta-lactamase-Producing Pseudomonas aeruginosa Including IMP-Types.
    J Med Chem. 2026;69:5560-5574.
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    February 2026
  29. VALDERRAMA K, Horlacher O, Publicola G, Eisenring P, et al
    Optimizing the Antibiotic Potency and Metabolic Stability of Pyridomycin Using a Semisynthetic Approach.
    J Med Chem. 2026;69:2496-2508.
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  30. XUE R, Luo C, Dou L, Yu X, et al
    Design and Synthesis of Membrane-Targeting Poly-Ruthenium Complexes Containing Quaternary Ammonium Cations with Potential Antibacterial Activity against Methicillin-Resistant Staphylococcus aureus (MRSA).
    J Med Chem. 2026 Feb 4. doi: 10.1021/acs.jmedchem.5c02644.
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    January 2026
  31. WEN R, Xing G, Li H, Yang J, et al
    Design, Synthesis, and Biological Evaluation of Acid-Responsive Bifunctional Molecules with Dual Anti-Helicobacter pylori and Acid Suppression Activities.
    J Med Chem. 2026;69:1342-1357.
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  32. ZHANG W, Chen J, Fang M, Song M, et al
    Discovery and Structural Optimization of Spirodioxynaphthalene-Based Mdr1 Efflux Pump Inhibitor to Combat Azole Resistance in Candida albicans.
    J Med Chem. 2026 Jan 14. doi: 10.1021/acs.jmedchem.5c03455.
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  33. SINGH S, Ng PS, Lakshmanan U, Mathiyazakan V, et al
    A Series of Pyrazolo-Quinazoline Amines Inhibits the Cytochrome bd Oxidase in Mycobacterium tuberculosis.
    J Med Chem. 2026 Jan 13. doi: 10.1021/acs.jmedchem.5c01616.
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    December 2025
  34. YE J, Kan CH, Liu J, Tsang TF, et al
    Dithioether Inhibitors of Bacterial RNA Polymerase-Sigma Factor Interactions Exhibit In Vivo Efficacy against MRSA.
    J Med Chem. 2025;68:25352-25374.
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  35. KUMAR TA, Birua S, Mallojjala SC, Mukherjee P, et al
    A Mycobacteria-Specific Prodrug to Overcome Phenotypic AMR in Mycobacterium tuberculosis.
    J Med Chem. 2025 Dec 1. doi: 10.1021/acs.jmedchem.5c01848.
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    November 2025
  36. TAN YM, Wei YJ, Ahmad N, Zhang SL, et al
    Identification of Novel Benzopyridonyl Cyanovinylpyrimidines as Potential Broad-Spectrum Antibacterial Members.
    J Med Chem. 2025;68:24232-24259.
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  37. JIANG S, Zhang W, Tian L, Zeng C, et al
    Rational Leucine-Centric Design Confers Enhanced Proteolytic Stability and Reduced Toxicity of Antimicrobial Peptides against Multidrug-Resistant Bacterial Infections.
    J Med Chem. 2025;68:23006-23023.
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  38. CHAUDHARY K, Agrahari B, Sonker H, Dewan S, et al
    Discovery of Ruthenium(Arene) Metalloantibiotics: Advancing Selective and Potent Therapeutics against Gram-Negative Acinetobacter baumannii.
    J Med Chem. 2025;68:22264-22287.
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  39. DOMINGUEZ-CISNEROS H, Konai MM, Kim C, Rana N, et al
    Antibacterial Benzimidazole-2-Methanamines as Allosteric Modulators of Streptococcus pneumoniae Penicillin-Binding Protein 2x.
    J Med Chem. 2025 Nov 10. doi: 10.1021/acs.jmedchem.5c02273.
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    October 2025
  40. PODDAR SK, Dey K, Zheng G
    Harnessing Chimeric Degrader Technologies for Antimicrobial Innovation.
    J Med Chem. 2025;68:20930-20963.
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  41. KOVAR O, Kufa M, Finger V, Soukup O, et al
    Scaffold Hopping in Tuberculosis Drug Discovery: Principles, Applications, and Case Studies.
    J Med Chem. 2025 Oct 7. doi: 10.1021/acs.jmedchem.5c01100.
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    September 2025
  42. LEE JK, Lee CY, Son M, Kim B, et al
    A Novel Peptide Antibiotic Targeting Gram-Negative Infections Designed from Mycobacterium tuberculosis Adenylate Kinase.
    J Med Chem. 2025 Sep 4. doi: 10.1021/acs.jmedchem.5c01412.
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    August 2025
  43. HOLLY KJ, Tharra PR, Abutaleb NS, Nocentini A, et al
    Hit-to-Lead Optimization of Acetazolamide-Based Bacterial Carbonic Anhydrase Inhibitors with Efficacy In Vivo for Treatment of Vancomycin-Resistant Enterococci Septicemia.
    J Med Chem. 2025 Aug 29. doi: 10.1021/acs.jmedchem.5c01584.
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  44. SONKER H, Dewan S, Chaudhary K, Agrahari B, et al
    Water-Soluble Ruthenium(II) p-Cymene Complexes Mitigating Intracellular S. aureus Infection: Bridging Antibacterial Defense and Anticancer Therapy.
    J Med Chem. 2025;68:17897-17916.
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  45. DUAN M, Huang X, Qiu C, Sun L, et al
    Multiparameter Optimization of Broad-Spectrum Antibacterial Activity, ADMET Properties, and MAO-A/B Inhibition of Novel Biaryloxazolidinone-Hydrazone Derivatives: Identification of a Lead with In Vivo Efficacy against Linezolid-Resistant Staphylococcu
    J Med Chem. 2025 Aug 15. doi: 10.1021/acs.jmedchem.5c00037.
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  46. NI D, Liu G
    Iron Uptake Systems: Chemical Tools for Advancing Infectious Disease Treatment and Diagnosis.
    J Med Chem. 2025;68:15285-15338.
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  47. DAVIS SH, Mathieson M, Buchanan KI, Dawson A, et al
    Design and Development of Lysyl tRNA Synthetase Inhibitors, for the Treatment of Tuberculosis.
    J Med Chem. 2025 Aug 1. doi: 10.1021/acs.jmedchem.5c01331.
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    July 2025
  48. AMBROSIO FA, Marchese E, Listro R, Linciano P, et al
    In Silico-Guided Discovery and In Vitro Evaluation of Natural Sortase A Inhibitors to Fight Multidrug-Resistant Staphylococcus aureus.
    J Med Chem. 2025 Jul 30. doi: 10.1021/acs.jmedchem.5c01009.
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  49. LONG HZ, Tang W, Huang MY, Yang GB, et al
    Discovery of Dual-Acting Biofilm Inhibitors against Pseudomonas aeruginosa by the Coupling of 3-Hydroxypyridin-4(1H)-ones with N-Phenylamide QS Inhibitors.
    J Med Chem. 2025;68:14756-14781.
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  50. LUO J, Yin J, Xie G, Li Z, et al
    Discovery of SaClpP-Selective Imipridone Derivatives as Novel Antistaphylococcal Agents.
    J Med Chem. 2025;68:14555-14568.
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  51. KAVANAGH ME, McLean KJ, Gilbert SH, Amadi CN, et al
    Fragment-Based Development of Small Molecule Inhibitors Targeting Mycobacterium tuberculosis Cholesterol Metabolism.
    J Med Chem. 2025 Jul 13. doi: 10.1021/acs.jmedchem.5c00478.
    >> Share

  52. SINGH M, Boomgaren M, Bakht P, Ihle P, et al
    Design and SAR Analysis of Phenylboronic Acid-Based Inhibitors for Sensitizing KPC-2-Producing Klebsiella pneumoniae to beta-Lactam Antibiotics.
    J Med Chem. 2025;68:13421-13435.
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    June 2025
  53. CHEN Y, Li Y, Nahar KS, Hasan MM, et al
    New Generation Modified Azole Antifungals against Multidrug-Resistant Candida auris.
    J Med Chem. 2025 Jun 23. doi: 10.1021/acs.jmedchem.5c01253.
    >> Share

  54. LIN J, Yang W, Xin J, Cao H, et al
    Lead Optimization and Target Identification of Carboline Antifungal Agents.
    J Med Chem. 2025;68:11502-11515.
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  55. NEGI A, Perveen S, Kour H, Singh PP, et al
    Keeping Up with the Q's: Mechanistic Insights and Validation of Quinoline and Quinazoline Scaffolds as Potent Drugs against Tuberculosis.
    J Med Chem. 2025 Jun 10. doi: 10.1021/acs.jmedchem.4c02568.
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    May 2025
  56. SONKER H, Chaudhary K, Agrahari B, Dewan S, et al
    De Novo 3-(Phenylcarbamoyl) Benzoate Analogues: Efficacy against Multidrug-Resistant S. aureus and Elucidation of the Biodistribution Profile.
    J Med Chem. 2025;68:10329-10345.
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  57. PUJARI AK, Kirar S, Gogde K, Rawat K, et al
    Designing Lignin-Based Nanophotocomposites as Reactive Oxygen Species Generators for Inactivating Candida Strains.
    J Med Chem. 2025 May 12. doi: 10.1021/acs.jmedchem.5c00482.
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  58. ANTONINI G, Fares M, Hauck D, Mala P, et al
    Toward Dual-Target Glycomimetics against Two Bacterial Lectins to Fight Pseudomonas aeruginosa-Burkholderia cenocepacia Infections: A Biophysical Study.
    J Med Chem. 2025;68:9681-9693.
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  59. TIAN L, Wang T, Luan L, Meng Z, et al
    Terminally Symmetric beta-Turn Peptides for Multidrug-Resistant Bacterial Infections.
    J Med Chem. 2025;68:9341-9356.
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  60. HEIDTMANN CV, Fisker CD, Logstrup S, Eriksen PG, et al
    Linker and Head-Group Exploration of Anti-MRSA Triaromatic Pleuromutilins.
    J Med Chem. 2025;68:9479-9500.
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    April 2025
  61. XIE Y, Wang X, Chang T, Chen Z, et al
    Novel Aryl Sulfonium Modification on Vancomycin to Tackle MRSA and VRE In Vitro and In Vivo through Dual Enhanced Cell-Wall and Membrane Inhibition.
    J Med Chem. 2025;68:8310-8329.
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  62. LIANG T, Tu J, He Q, Zou P, et al
    Discovery of New Pyrazolone Carbothioamide Derivatives as Potent Antifungal Agents for the Treatment of Candidiasis and Cryptococcosis.
    J Med Chem. 2025;68:8439-8454.
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  63. XU T, Xue Z, Li X, Zhang M, et al
    Development of Membrane-Targeting Osthole Derivatives Containing Pyridinium Quaternary Ammonium Moieties with Potent Anti-Methicillin-Resistant Staphylococcus aureus Properties.
    J Med Chem. 2025;68:7459-7475.
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  64. LIU K, Liu Y, Wang Q, Nazare M, et al
    PaAP-Activatable NIR Probe for Diagnosing, Imaging, and Discovering Small-Molecule Therapeutics against Implant-Associated Biofilm Infections.
    J Med Chem. 2025;68:7827-7838.
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    March 2025
  65. ZHANG ZM, Zhao SY, Liu WQ, Wu X, et al
    Hybrid Molecules of Benzothiazole and Hydroxamic Acid as Dual-Acting Biofilm Inhibitors with Antibacterial Synergistic Effect against Pseudomonas aeruginosa Infections.
    J Med Chem. 2025;68:6210-6232.
    >> Share

  66. HE Y, Su J, Li M, Fareed MS, et al
    Discovery of Cationic Lugdunin Derivatives with Membrane-Disrupting Activity against Resistant Bacteria via Radical Reactions and Amino Acid Mutations.
    J Med Chem. 2025;68:5699-5718.
    >> Share

  67. CARDOSO J, Pinto E, Sousa E, Resende DISP, et al
    Redefining Antifungal Treatment: The Innovation of Metal-Based Compounds.
    J Med Chem. 2025;68:5006-5023.
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  68. SHARMA P, Jiang Q, Li SG, Ocke E, et al
    Evolution of Small Molecule Inhibitors of Mycobacterium tuberculosis Menaquinone Biosynthesis.
    J Med Chem. 2025 Mar 4. doi: 10.1021/acs.jmedchem.4c03156.
    >> Share

  69. CAZZANIGA G, Mori M, Griego A, Scarpa E, et al
    Nanoenabling MbtI Inhibitors for Next-Generation Tuberculosis Therapy.
    J Med Chem. 2025 Mar 3. doi: 10.1021/acs.jmedchem.4c02386.
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    February 2025
  70. ZIMMERMANN T, Feng J, Fischer S, de Campos LJ, et al
    Structural Optimization of Covalent Inhibitors for Deubiquitinase ChlaDUB1 of Chlamydia trachomatis as Antibiotic Agents.
    J Med Chem. 2025 Feb 28. doi: 10.1021/acs.jmedchem.4c02464.
    >> Share

  71. XU L, Wang Y, Hu S, Pei Y, et al
    Discovery of Metabolic Reprogramming 2-Quinolones as Effective Antimicrobials for MRSA-Infected Wound Therapy.
    J Med Chem. 2025;68:3004-3019.
    >> Share

    January 2025
  72. LI G, Chen W, Guan H, Lai Z, et al
    Dendritic Antifungal Peptides as Potent Agents against Drug-Resistant Candida albicans and Biofilm.
    J Med Chem. 2025 Jan 27. doi: 10.1021/acs.jmedchem.4c02598.
    >> Share

  73. ZHANG M, Yang W, Liu N, Tu J, et al
    Lanosterol 14alpha-Demethylase (CYP51)/Heat Shock Protein 90 (Hsp90) Dual Inhibitors for the Treatment of Invasive Candidiasis.
    J Med Chem. 2025;68:1668-1681.
    >> Share

  74. YAN X, Yang C, Li B, Bian Y, et al
    Positive Charge-Concentrated Dimeric Lipopeptides with Enhanced Protease Resistance: A Potential Solution for Systemic Bacterial Infections.
    J Med Chem. 2025;68:1397-1416.
    >> Share

  75. ZHANG T, Wu W, Zhao Y, Ding Z, et al
    Structure-Guided Development of ClpP Agonists with Potent Therapeutic Activities against Staphylococcus aureus Infection.
    J Med Chem. 2025 Jan 6. doi: 10.1021/acs.jmedchem.4c02562.
    >> Share

    December 2024
  76. LIU X, Wang D, Wei X, Yang D, et al
    Selectively Antagonizing the NOD1-Mediated Inflammatory Signaling Pathway Mitigates the Gastric Inflammation Induced by Helicobacter pylori Infection.
    J Med Chem. 2024;67:22145-22167.
    >> Share

  77. DA SILVA FF, Paz JD, Rambo RS, Goncalves GA, et al
    Unveiling the Antimycobacterial Potential of Novel 4-Alkoxyquinolines: Insights into Selectivity, Mechanism of Action, and In Vivo Exposure.
    J Med Chem. 2024;67:21781-21794.
    >> Share

  78. RANI N, Rajmani RS, Surolia A
    Identification of an Isoxazole Derivative as an Antitubercular Compound for Targeting the FadD Enzymes of Mycobacterium tuberculosis.
    J Med Chem. 2024 Dec 18. doi: 10.1021/acs.jmedchem.4c01844.
    >> Share

  79. LIU K, Xia J, Li Y, Li BB, et al
    Discovery of Novel Coumarin Pleuromutilin Derivatives as Potent Anti-MRSA Agents.
    J Med Chem. 2024;67:21030-21048.
    >> Share

  80. BERIDA T, Lindsley CW
    Move over COVID, Tuberculosis Is Once again the Leading Cause of Death from a Single Infectious Disease.
    J Med Chem. 2024 Dec 9. doi: 10.1021/acs.jmedchem.4c02876.
    >> Share

    November 2024
  81. LIU JJ, Liu J, Huang YS, Chen WM, et al
    Cyclic Diguanylate G-Quadruplex Inducer-Quorum Sensing Inhibitor Hybrids as Bifunctional Anti-biofilm and Anti-virulence Agents Against Pseudomonas aeruginosa.
    J Med Chem. 2024;67:18911-18929.
    >> Share

    October 2024
  82. YAN D, Kong H, Qu Y, Li R, et al
    Development of Phloroglucinol-Linked Tris-Quaternary Ammonium Salt Antimicrobial Peptide Mimics with Low Cytotoxicity and Broad-Spectrum Antibacterial Activity.
    J Med Chem. 2024;67:18576-18592.
    >> Share

    September 2024
  83. MIAO ZY, Zhang XY, Long HZ, Lin J, et al
    Hybrids of 3-Hydroxypyridin-4(1H)-ones and Long-Chain 4-Aminoquinolines as Potent Biofilm Inhibitors of Pseudomonas aeruginosa Potentiate Tobramycin and Polymyxin B Activity.
    J Med Chem. 2024;67:16835-16857.
    >> Share

  84. MAJI S, Akhtar S, Halder S, Chatterjee I, et al
    Corannulene Amino Acid-Derived Water-Soluble Amphiphilic Buckybowls as Broad-Spectrum Membrane Targeting Antibacterial Agents.
    J Med Chem. 2024;67:15041-15060.
    >> Share

  85. SKUDLAREK JW, Cooke AJ, Mitchell HJ, Babaoglu K, et al
    Cerastecin Inhibition of the Lipooligosaccharide Transporter MsbA to Combat Acinetobacter baumannii: From Screening Impurity to In Vivo Efficacy.
    J Med Chem. 2024;67:15620-15675.
    >> Share

  86. YOUSE MS, Abutaleb NS, Nocentini A, S Abdelsattar A, et al
    Optimization of Ethoxzolamide Analogs with Improved Pharmacokinetic Properties for In Vivo Efficacy against Neisseria gonorrhoeae.
    J Med Chem. 2024;67:15537-15556.
    >> Share

  87. YANG R, Cui L, Xu S, Zhong Y, et al
    Membrane-Targeting Amphiphilic Honokiol Derivatives Containing an Oxazole Moiety as Potential Antibacterials against Methicillin-Resistant Staphylococcus aureus.
    J Med Chem. 2024 Sep 11. doi: 10.1021/acs.jmedchem.4c01860.
    >> Share

    August 2024
  88. LI K, Tolentino Collado J, Marden JA, Pollard AC, et al
    Biological Evaluation of d-[(18)F]Fluoroalanine and d-[(18)F]Fluoroalanine-d(3) as Positron Emission Tomography Imaging Tracers for Bacterial Infection.
    J Med Chem. 2024;67:13975-13984.
    >> Share

  89. CHARRIA-GIRON E, Zeng H, Gorelik TE, Pahl A, et al
    Arcopilins: A New Family of Staphylococcus aureus Biofilm Disruptors from the Soil Fungus Arcopilus navicularis.
    J Med Chem. 2024 Aug 14. doi: 10.1021/acs.jmedchem.4c00585.
    >> Share

  90. PELLICCIA S, Russomanno P, Barone S, Mateu B, et al
    A First-in-Class Pyrazole-isoxazole Enhanced Antifungal Activity of Voriconazole: Synergy Studies in an Azole-Resistant Candida albicans Strain, Computational Investigation and in Vivo Validation in a Galleria mellonella Fungal Infection Model.
    J Med Chem. 2024 Aug 8. doi: 10.1021/acs.jmedchem.4c01109.
    >> Share

  91. YAN Z, Li Q, Li X, Wang H, et al
    Discovery of Novel alpha,beta-Unsaturated Amide Derivatives as Candidate Antifungals to Overcome Fungal Resistance.
    J Med Chem. 2024;67:12601-12617.
    >> Share

    July 2024
  92. YU Z, Liang YC, Berton S, Liu L, et al
    Small Molecule Targeting PPM1A Activates Autophagy for Mycobacterium tuberculosis Host-Directed Therapy.
    J Med Chem. 2024 Jul 3. doi: 10.1021/acs.jmedchem.4c00513.
    >> Share

    June 2024
  93. ZHANG L, Yang J, Xu X, Zhang J, et al
    Discovery and Optimization of Novel SaFabI Inhibitors as Specific Therapeutic Agents for MRSA Infection.
    J Med Chem. 2024;67:10096-10134.
    >> Share

  94. MULAR A, Hubmann I, Petrik M, Bendova K, et al
    Biomimetic Analogues of the Desferrioxamine E Siderophore for PET Imaging of Invasive Aspergillosis: Targeting Properties and Species Specificity.
    J Med Chem. 2024 Jun 22. doi: 10.1021/acs.jmedchem.4c00887.
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  95. ZIMMERMANN T, Feng J, de Campos LJ, Knight LA, et al
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    J Med Chem. 2024 Jun 19. doi: 10.1021/acs.jmedchem.4c00230.
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  96. RUEEDI G, Panchaud P, Friedli A, Specklin JL, et al
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    May 2024
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    Construction and Activity Evaluation of Novel Bifunctional Inhibitors and a COF Carrier Based on a Fungal Infection Microenvironment.
    J Med Chem. 2024;67:8420-8444.
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  98. WANG X, Jin X, Zhao F, Xu Z, et al
    Structure-Based Optimization of Novel Sterol 24-C-Methyltransferase Inhibitors for the Treatment of Candida albicans Infections.
    J Med Chem. 2024 May 19. doi: 10.1021/acs.jmedchem.4c00470.
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  99. HE Y, Ruan S, Liang G, Hao J, et al
    A Nonbactericidal Anionic Antimicrobial Peptide Provides Prophylactic and Therapeutic Efficacies against Bacterial Infections in Mice by Immunomodulatory-Antithrombotic Duality.
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    April 2024
  100. NI T, Hao Y, Ding Z, Chi X, et al
    Discovery of a Novel Potent Tetrazole Antifungal Candidate with High Selectivity and Broad Spectrum.
    J Med Chem. 2024;67:6238-6252.
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    March 2024
  101. YANG W, Liu R, Li Z, Tu J, et al
    Discovery of New Tricyclic Oxime Sampangine Derivatives as Potent Antifungal Agents for the Treatment of Cryptococcosis and Candidiasis.
    J Med Chem. 2024;67:4726-4738.
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  102. MUSZALSKA-KOLOS I, Dwiecki PM
    Searching for Conjugates as New Structures for Antifungal Therapies.
    J Med Chem. 2024;67:4298-4321.
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  103. FRANCO AR, Sadones O, Romerio A, Artusa V, et al
    Novel TLR4-Activating Vaccine Adjuvant Enhances the Production of Enterococcus faecium-binding Antibodies.
    J Med Chem. 2024 Mar 21. doi: 10.1021/acs.jmedchem.3c02215.
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  104. XU T, Yan X, Kang A, Yang L, et al
    Development of Membrane-Targeting Fluorescent 2-Phenyl-1H-phenanthro[9,10-d]imidazole-Antimicrobial Peptide Mimic Conjugates against Methicillin-Resistant Staphylococcus aureus.
    J Med Chem. 2024 Mar 16. doi: 10.1021/acs.jmedchem.4c00436.
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  105. HEIDTMANN CV, Fejer AR, Staerk K, Pedersen M, et al
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    J Med Chem. 2024;67:3692-3710.
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  106. XIE F, Hao Y, Liu Y, Bao J, et al
    From Synergy to Monotherapy: Discovery of Novel 2,4,6-Trisubstituted Triazine Hydrazone Derivatives with Potent Antifungal Potency In Vitro and In Vivo.
    J Med Chem. 2024;67:4007-4025.
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  107. HUANG Z, Gou X, Hang X, Shi T, et al
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    J Med Chem. 2024 Mar 11. doi: 10.1021/acs.jmedchem.3c02355.
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    February 2024
  108. MADDIRALA AR, Pinkner JS, Tamadonfar K, Sanick D, et al
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    J Med Chem. 2024 Feb 3. doi: 10.1021/acs.jmedchem.3c02128.
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    September 2023
  109. WANG J, Song Y, Huang Z, Lin W, et al
    Coupling a Virulence-Targeting Moiety with Ru-Based AMP Mimics Efficiently Improved Its Anti-Infective Potency and Therapeutic Index.
    J Med Chem. 2023;66:13304-13318.
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