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Articles published in
J Med Chem
    July 2024
  1. YU Z, Liang YC, Berton S, Liu L, et al
    Small Molecule Targeting PPM1A Activates Autophagy for Mycobacterium tuberculosis Host-Directed Therapy.
    J Med Chem. 2024 Jul 3. doi: 10.1021/acs.jmedchem.4c00513.
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    June 2024
  2. ZHANG L, Yang J, Xu X, Zhang J, et al
    Discovery and Optimization of Novel SaFabI Inhibitors as Specific Therapeutic Agents for MRSA Infection.
    J Med Chem. 2024;67:10096-10134.
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  3. MULAR A, Hubmann I, Petrik M, Bendova K, et al
    Biomimetic Analogues of the Desferrioxamine E Siderophore for PET Imaging of Invasive Aspergillosis: Targeting Properties and Species Specificity.
    J Med Chem. 2024 Jun 22. doi: 10.1021/acs.jmedchem.4c00887.
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  4. ZIMMERMANN T, Feng J, de Campos LJ, Knight LA, et al
    Structure-Based Design and Synthesis of Covalent Inhibitors for Deubiquitinase and Acetyltransferase ChlaDUB1 of Chlamydia trachomatis.
    J Med Chem. 2024 Jun 19. doi: 10.1021/acs.jmedchem.4c00230.
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  5. RUEEDI G, Panchaud P, Friedli A, Specklin JL, et al
    Discovery and Structure-Activity Relationship of Cadazolid: A First-In-Class Quinoxolidinone Antibiotic for the Treatment of Clostridioides difficile Infection.
    J Med Chem. 2024;67:9465-9484.
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    May 2024
  6. YU S, He YQ, Liu Y, Ji S, et al
    Construction and Activity Evaluation of Novel Bifunctional Inhibitors and a COF Carrier Based on a Fungal Infection Microenvironment.
    J Med Chem. 2024;67:8420-8444.
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  7. WANG X, Jin X, Zhao F, Xu Z, et al
    Structure-Based Optimization of Novel Sterol 24-C-Methyltransferase Inhibitors for the Treatment of Candida albicans Infections.
    J Med Chem. 2024 May 19. doi: 10.1021/acs.jmedchem.4c00470.
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  8. HE Y, Ruan S, Liang G, Hao J, et al
    A Nonbactericidal Anionic Antimicrobial Peptide Provides Prophylactic and Therapeutic Efficacies against Bacterial Infections in Mice by Immunomodulatory-Antithrombotic Duality.
    J Med Chem. 2024;67:7487-7503.
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    April 2024
  9. NI T, Hao Y, Ding Z, Chi X, et al
    Discovery of a Novel Potent Tetrazole Antifungal Candidate with High Selectivity and Broad Spectrum.
    J Med Chem. 2024;67:6238-6252.
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    March 2024
  10. YANG W, Liu R, Li Z, Tu J, et al
    Discovery of New Tricyclic Oxime Sampangine Derivatives as Potent Antifungal Agents for the Treatment of Cryptococcosis and Candidiasis.
    J Med Chem. 2024;67:4726-4738.
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  11. MUSZALSKA-KOLOS I, Dwiecki PM
    Searching for Conjugates as New Structures for Antifungal Therapies.
    J Med Chem. 2024;67:4298-4321.
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  12. FRANCO AR, Sadones O, Romerio A, Artusa V, et al
    Novel TLR4-Activating Vaccine Adjuvant Enhances the Production of Enterococcus faecium-binding Antibodies.
    J Med Chem. 2024 Mar 21. doi: 10.1021/acs.jmedchem.3c02215.
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  13. XU T, Yan X, Kang A, Yang L, et al
    Development of Membrane-Targeting Fluorescent 2-Phenyl-1H-phenanthro[9,10-d]imidazole-Antimicrobial Peptide Mimic Conjugates against Methicillin-Resistant Staphylococcus aureus.
    J Med Chem. 2024 Mar 16. doi: 10.1021/acs.jmedchem.4c00436.
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  14. HEIDTMANN CV, Fejer AR, Staerk K, Pedersen M, et al
    Hit-to-Lead Identification and Validation of a Triaromatic Pleuromutilin Antibiotic Candidate.
    J Med Chem. 2024;67:3692-3710.
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  15. XIE F, Hao Y, Liu Y, Bao J, et al
    From Synergy to Monotherapy: Discovery of Novel 2,4,6-Trisubstituted Triazine Hydrazone Derivatives with Potent Antifungal Potency In Vitro and In Vivo.
    J Med Chem. 2024;67:4007-4025.
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  16. HUANG Z, Gou X, Hang X, Shi T, et al
    Design, Synthesis, and Biological Evaluation of 5-(5-Iodo-2-isopropyl-4-methoxyphenoxy)pyrimidine-2,4-diamine (AF-353) Derivatives as Novel DHFR Inhibitors against Staphylococcus aureus.
    J Med Chem. 2024 Mar 11. doi: 10.1021/acs.jmedchem.3c02355.
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    February 2024
  17. NEGI A, Perveen S, Gupta R, Singh PP, et al
    Unraveling Dilemmas and Lacunae in the Escalating Drug Resistance of Mycobacterium tuberculosis to Bedaquiline, Delamanid, and Pretomanid.
    J Med Chem. 2024 Feb 13. doi: 10.1021/acs.jmedchem.3c01892.
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  18. CUI Y, Lanne A, Peng X, Browne E, et al
    Azetidines Kill Multidrug-Resistant Mycobacterium tuberculosis without Detectable Resistance by Blocking Mycolate Assembly.
    J Med Chem. 2024 Feb 8. doi: 10.1021/acs.jmedchem.3c01643.
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  19. MADDIRALA AR, Pinkner JS, Tamadonfar K, Sanick D, et al
    Discovery of Orally Bioavailable FmlH Lectin Antagonists as Treatment for Urinary Tract Infections.
    J Med Chem. 2024 Feb 3. doi: 10.1021/acs.jmedchem.3c02128.
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    January 2024
  20. GUO W, Yang Z, Wang K, Li W, et al
    Discovery of Unique Bis-Substituted Aromatic Amide Derivatives as Novel Highly Potent Antibiotics for Combating Methicillin-Resistant Staphylococcus aureus (MRSA).
    J Med Chem. 2024 Jan 30. doi: 10.1021/acs.jmedchem.3c02064.
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  21. SOUKARIEH F, Mashabi A, Richardson W, Oton EV, et al
    Design, Synthesis, and Evaluation of New 1H-Benzo[d]imidazole Based PqsR Inhibitors as Adjuvant Therapy for Pseudomonas aeruginosa Infections.
    J Med Chem. 2024;67:1008-1023.
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  22. YANG L, Hu X, Lu Y, Xu R, et al
    Discovery of N-(1-(6-Oxo-1,6-dihydropyrimidine)-pyrazole) Acetamide Derivatives as Novel Noncovalent DprE1 Inhibitors against Mycobacterium tuberculosis.
    J Med Chem. 2024 Jan 17. doi: 10.1021/acs.jmedchem.3c01703.
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  23. GALLARDO-MACIAS R, Russo R, Sherwood M, Jaskowski M, et al
    Small Molecule Benzothiophene with In Vivo Efficacy in a Mouse Model of Drug-Resistant Enterococcus faecium Infection.
    J Med Chem. 2024 Jan 15. doi: 10.1021/acs.jmedchem.3c01846.
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  24. SANYAL K, Haldar J, Lindsley CW, Chibale K, et al
    Call for Papers: Fungal Pathogens - Life Cycle, Infection, Host Immunity and Drug Discovery.
    J Med Chem. 2024;67:1.
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  25. CUN WY, Bate CE, Srikhanta YN, Hutton ML, et al
    Design, Synthesis, and Evaluation of Cephamycin-Based Antisporulation Agents targeting Clostridioides difficile.
    J Med Chem. 2024;67:450-466.
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  26. LI C, Zhou Z, Wang W, Zhao Y, et al
    Development of Antibacterial Peptides with Membrane Disruption and Folate Pathway Inhibitory Activities against Methicillin-Resistant Staphylococcus aureus.
    J Med Chem. 2024 Jan 3. doi: 10.1021/acs.jmedchem.3c01360.
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  27. YUE C, Yuan Z, Xu G, Guan XN, et al
    Structure-Guided Design, Synthesis, and Antivirulence Assessment of Covalent Staphylococcus aureus Sortase A Inhibitors.
    J Med Chem. 2024 Jan 3. doi: 10.1021/acs.jmedchem.3c01615.
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    December 2023
  28. RENARD S, Versluys S, Taillier T, Dubarry N, et al
    Optimization of the Antibacterial Spectrum and the Developability Profile of the Novel-Class Natural Product Corramycin.
    J Med Chem. 2023;66:16869-16887.
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  29. OLIVEIRA NJC, Dos Santos Junior VS, Pierotte IC, Leocadio VAT, et al
    Discovery of Lead 2-Thiazolylhydrazones with Broad-Spectrum and Potent Antifungal Activity.
    J Med Chem. 2023;66:16628-16645.
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  30. LIN H, Song L, Zhou S, Fan C, et al
    A Hybrid Antimicrobial Peptide Targeting Staphylococcus aureus with a Dual Function of Inhibiting Quorum Sensing Signaling and an Antibacterial Effect.
    J Med Chem. 2023 Dec 15. doi: 10.1021/acs.jmedchem.3c02027.
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  31. LIN Y, Jung H, Bulman CA, Ng J, et al
    Discovery of New Broad-Spectrum Anti-Infectives for Eukaryotic Pathogens Using Bioorganometallic Chemistry.
    J Med Chem. 2023;66:15867-15882.
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  32. MIAO ZY, Zhang XY, Yang MH, Huang YJ, et al
    3-Hydroxypyridin-4(1H)-one Derivatives as pqs Quorum Sensing Inhibitors Attenuate Virulence and Reduce Antibiotic Resistance in Pseudomonas aeruginosa.
    J Med Chem. 2023;66:15823-15846.
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  33. LI L, Wu H, Wang J, Ji Z, et al
    Discovery of Novel 8-Hydroxyquinoline Derivatives with Potent In Vitro and In Vivo Antifungal Activity.
    J Med Chem. 2023;66:16364-16376.
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  34. YANG Y, Zhao N, Xu X, Zhou Y, et al
    Discovery and Mechanistic Study of Novel Mycobacterium tuberculosis ClpP1P2 Inhibitors.
    J Med Chem. 2023 Dec 13. doi: 10.1021/acs.jmedchem.3c01054.
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    November 2023
  35. CEBULA J, Fink K, Goldeman W, Szermer-Olearnik B, et al
    Structural Patterns Enhancing the Antibacterial Activity of Metallacarborane-Based Antibiotics.
    J Med Chem. 2023;66:14948-14962.
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    October 2023
  36. KARAN S, Cho MY, Lee H, Kim HM, et al
    Hypoxia-Directed and Self-Immolative Theranostic Agent: Imaging and Treatment of Cancer and Bacterial Infections.
    J Med Chem. 2023;66:14175-14187.
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  37. BARBACHYN MR
    Identification of a 1,2,4-Oxadiazole with Potent and Specific Activity against Clostridioides difficile, the Causative Bacterium of C. difficile Infection, an Urgent Public Health Threat.
    J Med Chem. 2023;66:13888-13890.
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  38. WANG F, Wu J, Yuan M, Yan Z, et al
    Novel Nitric Oxide Donor-Azole Conjugation Strategy for Efficient Treatment of Cryptococcus neoformans Infections.
    J Med Chem. 2023;66:14221-14240.
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  39. LIMWONGYUT J, Moreland AS, Zhang K, Raynor M, et al
    Amidine-Based Cationic Conjugated Oligoelectrolytes with Antimicrobial Activity against Pseudomonas aeruginosa Biofilms.
    J Med Chem. 2023;66:14303-14314.
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  40. KIM D, Lee J, Shyaka C, Kwak JH, et al
    Identification of Micrococcin P2-Derivatives as Antibiotic Candidates against Two Gram-Positive Pathogens.
    J Med Chem. 2023;66:14263-14277.
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  41. QIAN Y, Birhanu BT, Yang J, Ding D, et al
    A Potent and Narrow-Spectrum Antibacterial against Clostridioides difficile Infection.
    J Med Chem. 2023;66:13891-13899.
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  42. NANDAKUMAR M, Ollodart A, Fleck N, Kapadia NR, et al
    Dual Inhibition of Mycobacterium tuberculosis and the Host TGFBR1 by an Anilinoquinazoline.
    J Med Chem. 2023 Oct 23. doi: 10.1021/acs.jmedchem.3c01273.
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  43. PESLALZ P, Grieshober M, Kraus F, Bleisch A, et al
    Unnatural Endotype B PPAPs as Novel Compounds with Activity against Mycobacterium tuberculosis.
    J Med Chem. 2023 Oct 12. doi: 10.1021/acs.jmedchem.3c01172.
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  44. WANG X, Jin X, Xie Z, Zhang H, et al
    Benzamidine Conjugation Converts Expelled Potential Active Agents into Antifungals against Drug-Resistant Fungi.
    J Med Chem. 2023;66:13684-13704.
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    September 2023
  45. YAN Z, Huang Y, Zhao D, Li Z, et al
    Developing Novel Coumarin-Containing Azoles Antifungal Agents by the Scaffold Merging Strategy for Treating Azole-Resistant Candidiasis.
    J Med Chem. 2023;66:13247-13265.
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  46. WANG Q, Tu J, Yang W, Liang T, et al
    Discovery of Pyrazolone Carbothioamide Derivatives as Inhibitors of the Pdr1-KIX Interaction for Combinational Treatment of Azole-Resistant Candidiasis.
    J Med Chem. 2023;66:11893-11904.
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  47. GOGDE K, Paul S, Pujari AK, Yadav AK, et al
    Synthesis of Metallo-Chromone Porphyrin Nano-Starch Sensitizers as Photodynamic Therapeutics for the Eradication of Enterococci Dental Pathogens.
    J Med Chem. 2023 Sep 6. doi: 10.1021/acs.jmedchem.3c01087.
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    August 2023
  48. DEY S, Patel A, Haloi N, Srimayee S, et al
    Quinoline Thiourea-Based Zinc Ionophores with Antibacterial Activity.
    J Med Chem. 2023;66:11078-11093.
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    July 2023
  49. SARKAR S, Mayer Bridwell AE, Good JAD, Wang ER, et al
    Design, Synthesis, and Evaluation of Novel Delta(2)-Thiazolino 2-Pyridone Derivatives That Potentiate Isoniazid Activity in an Isoniazid-Resistant Mycobacterium tuberculosis Mutant.
    J Med Chem. 2023 Jul 24. doi: 10.1021/acs.jmedchem.3c00358.
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  50. VENNARD C, Oropo T, Sintim HO
    Engineered Vancomycin, with Increased Interactions with Peptidoglycan Stem Peptide, Conquers Non-tuberculosis Mycobacteria.
    J Med Chem. 2023 Jul 21. doi: 10.1021/acs.jmedchem.3c01219.
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    June 2023
  51. KOTEVA K, Xu M, Wang W, Fiebig-Comyn AA, et al
    Synthetic Biology Facilitates Semisynthetic Development of Type V Glycopeptide Antibiotics Targeting Vancomycin-Resistant Enterococcus.
    J Med Chem. 2023 Jun 14. doi: 10.1021/acs.jmedchem.3c00633.
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  52. BENDOVA K, Raclavsky V, Novotny R, Luptakova D, et al
    [(68)Ga]Ga-Ornibactin for Burkholderia cepacia complex Infection Imaging Using Positron Emission Tomography.
    J Med Chem. 2023;66:7584-7593.
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  53. AHIRWAR P, Kozlovskaya V, Nijampatnam B, Rojas EM, et al
    Hydrogel-Encapsulated Biofilm Inhibitors Abrogate the Cariogenic Activity of Streptococcus mutans.
    J Med Chem. 2023 Jun 7. doi: 10.1021/acs.jmedchem.3c00272.
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    May 2023
  54. MALWAL SR, Mazurek B, Ko J, Xie P, et al
    Investigation into the Mechanism of Action of the Tuberculosis Drug Candidate SQ109 and Its Metabolites and Analogues in Mycobacteria.
    J Med Chem. 2023 May 26. doi: 10.1021/acs.jmedchem.3c00398.
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  55. KONG H, Qin S, Yan D, Shen B, et al
    Development of Aromatic-Linked Diamino Acid Antimicrobial Peptide Mimics with Low Hemolytic Toxicity and Excellent Activity against Methicillin-Resistant Staphylococcus aureus (MRSA).
    J Med Chem. 2023 May 16. doi: 10.1021/acs.jmedchem.2c01583.
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    April 2023
  56. LANG M, Ganapathy US, Mann L, Abdelaziz R, et al
    Synthesis and Characterization of Phenylalanine Amides Active against Mycobacterium abscessus and Other Mycobacteria.
    J Med Chem. 2023;66:5079-5098.
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  57. TAN YM, Wang Y, Li S, Zhang SL, et al
    Azolylpyrimidinediols as Novel Structural Scaffolds of DNA-Groove Binders against Intractable Acinetobacter baumannii.
    J Med Chem. 2023;66:4910-4931.
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  58. LI Z, Huang Y, Tu J, Yang W, et al
    Discovery of BRD4-HDAC Dual Inhibitors with Improved Fungal Selectivity and Potent Synergistic Antifungal Activity against Fluconazole-Resistant Candida albicans.
    J Med Chem. 2023 Apr 10. doi: 10.1021/acs.jmedchem.3c00165.
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    March 2023
  59. DURCIK M, Cotman AE, Toplak Z, Mozina S, et al
    New Dual Inhibitors of Bacterial Topoisomerases with Broad-Spectrum Antibacterial Activity and In Vivo Efficacy against Vancomycin-Intermediate Staphylococcus aureus.
    J Med Chem. 2023 Mar 6. doi: 10.1021/acs.jmedchem.2c01905.
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    February 2023
  60. PATIL NA, Ma W, Jiang X, He X, et al
    Critical Role of Position 10 Residue in the Polymyxin Antimicrobial Activity.
    J Med Chem. 2023;66:2865-2876.
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  61. TENG P, Shao H, Huang B, Xie J, et al
    Small Molecular Mimetics of Antimicrobial Peptides as a Promising Therapy To Combat Bacterial Resistance.
    J Med Chem. 2023;66:2211-2234.
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  62. WANG YY, Zhang XY, Zhong XL, Huang YJ, et al
    Design and Synthesis of 3-Hydroxy-pyridin-4(1H)-ones-Ciprofloxacin Conjugates as Dual Antibacterial and Antibiofilm Agents against Pseudomonas aeruginosa.
    J Med Chem. 2023;66:2169-2193.
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  63. LI C, Tian X, Huang Z, Gou X, et al
    Structure-Activity Relationship of Novel Pyrimidine Derivatives with Potent Inhibitory Activities against Mycobacterium tuberculosis.
    J Med Chem. 2023 Feb 3. doi: 10.1021/acs.jmedchem.2c01647.
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    January 2023
  64. HUANG Y, Liu N, Pan Z, Li Z, et al
    BET-HDAC Dual Inhibitors for Combinational Treatment of Breast Cancer and Concurrent Candidiasis.
    J Med Chem. 2023;66:1239-1253.
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  65. BHATTARAI P, Hegde P, Li W, Prathipati PK, et al
    Structural Determinants of Indole-2-carboxamides: Identification of Lead Acetamides with Pan Antimycobacterial Activity.
    J Med Chem. 2023;66:170-187.
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    December 2022
  66. CHENG W, Xu T, Cui L, Xue Z, et al
    Discovery of Amphiphilic Xanthohumol Derivatives as Membrane-Targeting Antimicrobials against Methicillin-Resistant Staphylococcus aureus.
    J Med Chem. 2022 Dec 30. doi: 10.1021/acs.jmedchem.2c01793.
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  67. MANDAL M, Xiao L, Pan W, Scapin G, et al
    Rapid Evolution of a Fragment-like Molecule to Pan-Metallo-Beta-Lactamase Inhibitors: Initial Leads toward Clinical Candidates.
    J Med Chem. 2022;65:16234-16251.
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  68. YANG R, Hou E, Cheng W, Yan X, et al
    Membrane-Targeting Neolignan-Antimicrobial Peptide Mimic Conjugates to Combat Methicillin-Resistant Staphylococcus aureus (MRSA) Infections.
    J Med Chem. 2022 Dec 13. doi: 10.1021/acs.jmedchem.2c01674.
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    November 2022
  69. GUO X, Yan T, Rao J, An Y, et al
    Novel Feleucin-K3-Derived Peptides Modified with Sulfono-gamma-AA Building Blocks Targeting Pseudomonas aeruginosa and Methicillin-Resistant Staphylococcus aureus Infections.
    J Med Chem. 2022 Nov 9. doi: 10.1021/acs.jmedchem.2c01396.
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  70. SAINI V, Mehta D, Gupta S, Kumar S, et al
    Targeting Vancomycin-Resistant Enterococci (VRE) Infections and Van Operon-Mediated Drug Resistance Using Dimeric Cholic Acid-Peptide Conjugates.
    J Med Chem. 2022 Nov 4. doi: 10.1021/acs.jmedchem.2c01293.
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    October 2022
  71. MEIERS J, Rox K, Titz A
    Lectin-Targeted Prodrugs Activated by Pseudomonas aeruginosa for Self-Destructive Antibiotic Release.
    J Med Chem. 2022;65:13988-14014.
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  72. KUBINSKI K, Maslyk M, Janeczko M, Goldeman W, et al
    Metallacarborane Derivatives as Innovative Anti-Candida albicans Agents.
    J Med Chem. 2022 Oct 11. doi: 10.1021/acs.jmedchem.2c01167.
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    September 2022
  73. ZHANG W, Lun S, Wang SS, Cai YP, et al
    Structure-Based Optimization of Coumestan Derivatives as Polyketide Synthase 13-Thioesterase(Pks13-TE) Inhibitors with Improved hERG Profiles for Mycobacterium tuberculosis Treatment.
    J Med Chem. 2022 Sep 29. doi: 10.1021/acs.jmedchem.2c01064.
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  74. ANG CW, Lee BM, Jackson CJ, Wang Y, et al
    Nitroimidazopyrazinones with Oral Activity against Tuberculosis and Chagas Disease in Mouse Models of Infection.
    J Med Chem. 2022 Sep 16. doi: 10.1021/acs.jmedchem.2c00972.
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    August 2022
  75. LI L, Wu H, Zhu S, Ji Z, et al
    Discovery of Novel 7-Hydroxy-5-oxo-4,5-dihydrothieno[3,2-b]pyridine-6-carboxamide Derivatives with Potent and Selective Antifungal Activity against Cryptococcus Species.
    J Med Chem. 2022;65:11257-11269.
    >> Share

  76. HE T, Xu L, Hu Y, Tang X, et al
    Lysine-Tethered Stable Bicyclic Cationic Antimicrobial Peptide Combats Bacterial Infection in Vivo.
    J Med Chem. 2022;65:10523-10533.
    >> Share

  77. LI C, Liu S, Dong B, Li C, et al
    Discovery and Mechanistic Study of Mycobacterium tuberculosis PafA Inhibitors.
    J Med Chem. 2022 Aug 4. doi: 10.1021/acs.jmedchem.2c00289.
    >> Share

  78. ZHAO H, Gao Y, Li W, Sheng L, et al
    Design, Synthesis, and Biological Evaluation of Pyrrole-2-carboxamide Derivatives as Mycobacterial Membrane Protein Large 3 Inhibitors for Treating Drug-Resistant Tuberculosis.
    J Med Chem. 2022 Aug 1. doi: 10.1021/acs.jmedchem.2c00718.
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    July 2022
  79. BEN HUR D, Kapach G, Wani NA, Kiper E, et al
    Antimicrobial Peptides against Multidrug-Resistant Pseudomonas aeruginosa Biofilm from Cystic Fibrosis Patients.
    J Med Chem. 2022;65:9050-9062.
    >> Share

    June 2022
  80. BURASTERO O, Defelipe LA, Gola G, Tateosian NL, et al
    Cosolvent Sites-Based Discovery of Mycobacterium Tuberculosis Protein Kinase G Inhibitors.
    J Med Chem. 2022 Jun 23. doi: 10.1021/acs.jmedchem.1c02012.
    >> Share

  81. ZHANG X, Wang M, Zhu X, Peng Y, et al
    Development of Lipo-gamma-AA Peptides as Potent Antifungal Agents.
    J Med Chem. 2022;65:8029-8039.
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    May 2022
  82. WU Y, Jiang W, Cong Z, Chen K, et al
    An Effective Strategy to Develop Potent and Selective Antifungal Agents from Cell Penetrating Peptides in Tackling Drug-Resistant Invasive Fungal Infections.
    J Med Chem. 2022;65:7296-7311.
    >> Share

  83. FERNANDES GFS, Thompson AM, Castagnolo D, Denny WA, et al
    Tuberculosis Drug Discovery: Challenges and New Horizons.
    J Med Chem. 2022 May 25. doi: 10.1021/acs.jmedchem.2c00227.
    >> Share

  84. KOKOT M, Anderluh M, Hrast M, Minovski N, et al
    The Structural Features of Novel Bacterial Topoisomerase Inhibitors That Define Their Activity on Topoisomerase IV.
    J Med Chem. 2022;65:6431-6440.
    >> Share

  85. NACLERIO GA, Abutaleb NS, Onyedibe KI, Karanja C, et al
    Mechanistic Studies and In Vivo Efficacy of an Oxadiazole-Containing Antibiotic.
    J Med Chem. 2022;65:6612-6630.
    >> Share

  86. LI W, Yun Z, Ji C, Tu J, et al
    Discovery of Novel Sertraline Derivatives as Potent Anti-Cryptococcus Agents.
    J Med Chem. 2022;65:6541-6554.
    >> Share

    April 2022
  87. GURVIC D, Leach AG, Zachariae U
    Data-Driven Derivation of Molecular Substructures That Enhance Drug Activity in Gram-Negative Bacteria.
    J Med Chem. 2022;65:6088-6099.
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  88. LELLA M, Oh MW, Kuo SH, Lau GW, et al
    Attenuating the Streptococcus pneumoniae Competence Regulon Using Urea-Bridged Cyclic Dominant-Negative Competence-Stimulating Peptide Analogs.
    J Med Chem. 2022 Apr 22. doi: 10.1021/acs.jmedchem.2c00148.
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  89. YIN W, Wu T, Liu L, Jiang H, et al
    Species-Selective Targeting of Fungal Hsp90: Design, Synthesis, and Evaluation of Novel 4,5-Diarylisoxazole Derivatives for the Combination Treatment of Azole-Resistant Candidiasis.
    J Med Chem. 2022;65:5539-5564.
    >> Share

    March 2022
  90. MA Z, He S, Yuan Y, Zhuang Z, et al
    Design, Synthesis, and Characterization of TNP-2198, a Dual-Targeted Rifamycin-Nitroimidazole Conjugate with Potent Activity against Microaerophilic and Anaerobic Bacterial Pathogens.
    J Med Chem. 2022;65:4481-4495.
    >> Share

  91. KOBAURI P, Galenkamp NS, Schulte AM, de Vries J, et al
    Hypothesis-Driven, Structure-Based Design in Photopharmacology: The Case of eDHFR Inhibitors.
    J Med Chem. 2022;65:4798-4817.
    >> Share

    February 2022
  92. ACEBRON-GARCIA-DE-EULATE M, Mayol-Llinas J, Holland MTO, Kim SY, et al
    Discovery of Novel Inhibitors of Uridine Diphosphate-N-Acetylenolpyruvylglucosamine Reductase (MurB) from Pseudomonas aeruginosa, an Opportunistic Infectious Agent Causing Death in Cystic Fibrosis Patients.
    J Med Chem. 2022;65:2149-2173.
    >> Share

  93. MODAK B, Girkar S, Narayan R, Kapoor S, et al
    Mycobacterial Membranes as Actionable Targets for Lipid-Centric Therapy in Tuberculosis.
    J Med Chem. 2022 Feb 8. doi: 10.1021/acs.jmedchem.1c01870.
    >> Share

    January 2022
  94. OTTAVI S, Scarry SM, Mosior J, Ling Y, et al
    In Vitro and In Vivo Inhibition of the Mycobacterium tuberculosis Phosphopantetheinyl Transferase PptT by Amidinoureas.
    J Med Chem. 2022 Jan 19. doi: 10.1021/acs.jmedchem.1c01565.
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  95. SHYAM M, Verma H, Bhattacharje G, Mukherjee P, et al
    Mycobactin Analogues with Excellent Pharmacokinetic Profile Demonstrate Potent Antitubercular Specific Activity and Exceptional Efflux Pump Inhibition.
    J Med Chem. 2022;65:234-256.
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  96. HU Y, Li H, Qu R, He T, et al
    Lysine Stapling Screening Provides Stable and Low Toxic Cationic Antimicrobial Peptides Combating Multidrug-Resistant Bacteria In Vitro and In Vivo.
    J Med Chem. 2022;65:579-591.
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  97. LIU J, Hou JS, Chang YQ, Peng LJ, et al
    New Pqs Quorum Sensing System Inhibitor as an Antibacterial Synergist against Multidrug-Resistant Pseudomonas aeruginosa.
    J Med Chem. 2022;65:688-709.
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  98. LEE D, Lee E, Jang S, Kim K, et al
    Discovery of Mycobacterium tuberculosis Rv3364c-Derived Small Molecules as Potential Therapeutic Agents to Target SNX9 for Sepsis.
    J Med Chem. 2022 Jan 4. doi: 10.1021/acs.jmedchem.1c01551.
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    November 2021
  99. TRAN W, Kusay AS, Hawkins PME, Cheung CY, et al
    Synthetic Sansanmycin Analogues as Potent Mycobacterium tuberculosis Translocase I Inhibitors.
    J Med Chem. 2021 Nov 30. doi: 10.1021/acs.jmedchem.1c01407.
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  100. CHOI JW, Lee KT, Kim S, Lee YR, et al
    Optimization and Evaluation of Novel Antifungal Agents for the Treatment of Fungal Infection.
    J Med Chem. 2021;64:15912-15935.
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    October 2021
  101. PRATAP VERMA D, Ansari MM, Verma NK, Saroj J, et al
    Tandem Repeat of a Short Human Chemerin-Derived Peptide and Its Nontoxic d-Lysine-Containing Enantiomer Display Broad-Spectrum Antimicrobial and Antitubercular Activities.
    J Med Chem. 2021;64:15349-15366.
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  102. FRIDIANTO KT, Li M, Hards K, Negatu DA, et al
    Functionalized Dioxonaphthoimidazoliums: A Redox Cycling Chemotype with Potent Bactericidal Activities against Mycobacterium tuberculosis.
    J Med Chem. 2021 Oct 27. doi: 10.1021/acs.jmedchem.1c01383.
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  103. CHEN Z, Song K, Shang Y, Xiong Y, et al
    Selection and Identification of Novel Antibacterial Agents against Planktonic Growth and Biofilm Formation of Enterococcus faecalis.
    J Med Chem. 2021 Oct 16. doi: 10.1021/acs.jmedchem.1c00939.
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    August 2021
  104. PEUKERT C, Langer LNB, Wegener SM, Tutov A, et al
    Optimization of Artificial Siderophores as (68)Ga-Complexed PET Tracers for In Vivo Imaging of Bacterial Infections.
    J Med Chem. 2021;64:12359-12378.
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  105. GOU S, Li B, Ouyang X, Ba Z, et al
    Novel Broad-Spectrum Antimicrobial Peptide Derived from Anoplin and Its Activity on Bacterial Pneumonia in Mice.
    J Med Chem. 2021;64:11247-11266.
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    July 2021
  106. KATO I, Ukai Y, Kondo N, Nozu K, et al
    Identification of Thiazoyl Guanidine Derivatives as Novel Antifungal Agents Inhibiting Ergosterol Biosynthesis for Treatment of Invasive Fungal Infections.
    J Med Chem. 2021;64:10482-10496.
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