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Articles published in
J Med Chem
    May 2023
  1. MALWAL SR, Mazurek B, Ko J, Xie P, et al
    Investigation into the Mechanism of Action of the Tuberculosis Drug Candidate SQ109 and Its Metabolites and Analogues in Mycobacteria.
    J Med Chem. 2023 May 26. doi: 10.1021/acs.jmedchem.3c00398.
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  2. KONG H, Qin S, Yan D, Shen B, et al
    Development of Aromatic-Linked Diamino Acid Antimicrobial Peptide Mimics with Low Hemolytic Toxicity and Excellent Activity against Methicillin-Resistant Staphylococcus aureus (MRSA).
    J Med Chem. 2023 May 16. doi: 10.1021/acs.jmedchem.2c01583.
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    April 2023
  3. LANG M, Ganapathy US, Mann L, Abdelaziz R, et al
    Synthesis and Characterization of Phenylalanine Amides Active against Mycobacterium abscessus and Other Mycobacteria.
    J Med Chem. 2023;66:5079-5098.
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  4. TAN YM, Wang Y, Li S, Zhang SL, et al
    Azolylpyrimidinediols as Novel Structural Scaffolds of DNA-Groove Binders against Intractable Acinetobacter baumannii.
    J Med Chem. 2023;66:4910-4931.
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  5. LI Z, Huang Y, Tu J, Yang W, et al
    Discovery of BRD4-HDAC Dual Inhibitors with Improved Fungal Selectivity and Potent Synergistic Antifungal Activity against Fluconazole-Resistant Candida albicans.
    J Med Chem. 2023 Apr 10. doi: 10.1021/acs.jmedchem.3c00165.
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    March 2023
  6. DURCIK M, Cotman AE, Toplak Z, Mozina S, et al
    New Dual Inhibitors of Bacterial Topoisomerases with Broad-Spectrum Antibacterial Activity and In Vivo Efficacy against Vancomycin-Intermediate Staphylococcus aureus.
    J Med Chem. 2023 Mar 6. doi: 10.1021/acs.jmedchem.2c01905.
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    February 2023
  7. PATIL NA, Ma W, Jiang X, He X, et al
    Critical Role of Position 10 Residue in the Polymyxin Antimicrobial Activity.
    J Med Chem. 2023;66:2865-2876.
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  8. TENG P, Shao H, Huang B, Xie J, et al
    Small Molecular Mimetics of Antimicrobial Peptides as a Promising Therapy To Combat Bacterial Resistance.
    J Med Chem. 2023;66:2211-2234.
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  9. WANG YY, Zhang XY, Zhong XL, Huang YJ, et al
    Design and Synthesis of 3-Hydroxy-pyridin-4(1H)-ones-Ciprofloxacin Conjugates as Dual Antibacterial and Antibiofilm Agents against Pseudomonas aeruginosa.
    J Med Chem. 2023;66:2169-2193.
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  10. LI C, Tian X, Huang Z, Gou X, et al
    Structure-Activity Relationship of Novel Pyrimidine Derivatives with Potent Inhibitory Activities against Mycobacterium tuberculosis.
    J Med Chem. 2023 Feb 3. doi: 10.1021/acs.jmedchem.2c01647.
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    January 2023
  11. HUANG Y, Liu N, Pan Z, Li Z, et al
    BET-HDAC Dual Inhibitors for Combinational Treatment of Breast Cancer and Concurrent Candidiasis.
    J Med Chem. 2023;66:1239-1253.
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  12. BHATTARAI P, Hegde P, Li W, Prathipati PK, et al
    Structural Determinants of Indole-2-carboxamides: Identification of Lead Acetamides with Pan Antimycobacterial Activity.
    J Med Chem. 2023;66:170-187.
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    December 2022
  13. CHENG W, Xu T, Cui L, Xue Z, et al
    Discovery of Amphiphilic Xanthohumol Derivatives as Membrane-Targeting Antimicrobials against Methicillin-Resistant Staphylococcus aureus.
    J Med Chem. 2022 Dec 30. doi: 10.1021/acs.jmedchem.2c01793.
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  14. MANDAL M, Xiao L, Pan W, Scapin G, et al
    Rapid Evolution of a Fragment-like Molecule to Pan-Metallo-Beta-Lactamase Inhibitors: Initial Leads toward Clinical Candidates.
    J Med Chem. 2022;65:16234-16251.
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  15. YANG R, Hou E, Cheng W, Yan X, et al
    Membrane-Targeting Neolignan-Antimicrobial Peptide Mimic Conjugates to Combat Methicillin-Resistant Staphylococcus aureus (MRSA) Infections.
    J Med Chem. 2022 Dec 13. doi: 10.1021/acs.jmedchem.2c01674.
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    November 2022
  16. GUO X, Yan T, Rao J, An Y, et al
    Novel Feleucin-K3-Derived Peptides Modified with Sulfono-gamma-AA Building Blocks Targeting Pseudomonas aeruginosa and Methicillin-Resistant Staphylococcus aureus Infections.
    J Med Chem. 2022 Nov 9. doi: 10.1021/acs.jmedchem.2c01396.
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  17. SAINI V, Mehta D, Gupta S, Kumar S, et al
    Targeting Vancomycin-Resistant Enterococci (VRE) Infections and Van Operon-Mediated Drug Resistance Using Dimeric Cholic Acid-Peptide Conjugates.
    J Med Chem. 2022 Nov 4. doi: 10.1021/acs.jmedchem.2c01293.
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    October 2022
  18. MEIERS J, Rox K, Titz A
    Lectin-Targeted Prodrugs Activated by Pseudomonas aeruginosa for Self-Destructive Antibiotic Release.
    J Med Chem. 2022;65:13988-14014.
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  19. KUBINSKI K, Maslyk M, Janeczko M, Goldeman W, et al
    Metallacarborane Derivatives as Innovative Anti-Candida albicans Agents.
    J Med Chem. 2022 Oct 11. doi: 10.1021/acs.jmedchem.2c01167.
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    September 2022
  20. ZHANG W, Lun S, Wang SS, Cai YP, et al
    Structure-Based Optimization of Coumestan Derivatives as Polyketide Synthase 13-Thioesterase(Pks13-TE) Inhibitors with Improved hERG Profiles for Mycobacterium tuberculosis Treatment.
    J Med Chem. 2022 Sep 29. doi: 10.1021/acs.jmedchem.2c01064.
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  21. ANG CW, Lee BM, Jackson CJ, Wang Y, et al
    Nitroimidazopyrazinones with Oral Activity against Tuberculosis and Chagas Disease in Mouse Models of Infection.
    J Med Chem. 2022 Sep 16. doi: 10.1021/acs.jmedchem.2c00972.
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    August 2022
  22. LI L, Wu H, Zhu S, Ji Z, et al
    Discovery of Novel 7-Hydroxy-5-oxo-4,5-dihydrothieno[3,2-b]pyridine-6-carboxamide Derivatives with Potent and Selective Antifungal Activity against Cryptococcus Species.
    J Med Chem. 2022;65:11257-11269.
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  23. HE T, Xu L, Hu Y, Tang X, et al
    Lysine-Tethered Stable Bicyclic Cationic Antimicrobial Peptide Combats Bacterial Infection in Vivo.
    J Med Chem. 2022;65:10523-10533.
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  24. LI C, Liu S, Dong B, Li C, et al
    Discovery and Mechanistic Study of Mycobacterium tuberculosis PafA Inhibitors.
    J Med Chem. 2022 Aug 4. doi: 10.1021/acs.jmedchem.2c00289.
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  25. ZHAO H, Gao Y, Li W, Sheng L, et al
    Design, Synthesis, and Biological Evaluation of Pyrrole-2-carboxamide Derivatives as Mycobacterial Membrane Protein Large 3 Inhibitors for Treating Drug-Resistant Tuberculosis.
    J Med Chem. 2022 Aug 1. doi: 10.1021/acs.jmedchem.2c00718.
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    July 2022
  26. BEN HUR D, Kapach G, Wani NA, Kiper E, et al
    Antimicrobial Peptides against Multidrug-Resistant Pseudomonas aeruginosa Biofilm from Cystic Fibrosis Patients.
    J Med Chem. 2022;65:9050-9062.
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    June 2022
  27. BURASTERO O, Defelipe LA, Gola G, Tateosian NL, et al
    Cosolvent Sites-Based Discovery of Mycobacterium Tuberculosis Protein Kinase G Inhibitors.
    J Med Chem. 2022 Jun 23. doi: 10.1021/acs.jmedchem.1c02012.
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  28. ZHANG X, Wang M, Zhu X, Peng Y, et al
    Development of Lipo-gamma-AA Peptides as Potent Antifungal Agents.
    J Med Chem. 2022;65:8029-8039.
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    May 2022
  29. WU Y, Jiang W, Cong Z, Chen K, et al
    An Effective Strategy to Develop Potent and Selective Antifungal Agents from Cell Penetrating Peptides in Tackling Drug-Resistant Invasive Fungal Infections.
    J Med Chem. 2022;65:7296-7311.
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  30. FERNANDES GFS, Thompson AM, Castagnolo D, Denny WA, et al
    Tuberculosis Drug Discovery: Challenges and New Horizons.
    J Med Chem. 2022 May 25. doi: 10.1021/acs.jmedchem.2c00227.
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  31. KOKOT M, Anderluh M, Hrast M, Minovski N, et al
    The Structural Features of Novel Bacterial Topoisomerase Inhibitors That Define Their Activity on Topoisomerase IV.
    J Med Chem. 2022;65:6431-6440.
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  32. NACLERIO GA, Abutaleb NS, Onyedibe KI, Karanja C, et al
    Mechanistic Studies and In Vivo Efficacy of an Oxadiazole-Containing Antibiotic.
    J Med Chem. 2022;65:6612-6630.
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  33. LI W, Yun Z, Ji C, Tu J, et al
    Discovery of Novel Sertraline Derivatives as Potent Anti-Cryptococcus Agents.
    J Med Chem. 2022;65:6541-6554.
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    April 2022
  34. GURVIC D, Leach AG, Zachariae U
    Data-Driven Derivation of Molecular Substructures That Enhance Drug Activity in Gram-Negative Bacteria.
    J Med Chem. 2022;65:6088-6099.
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  35. LELLA M, Oh MW, Kuo SH, Lau GW, et al
    Attenuating the Streptococcus pneumoniae Competence Regulon Using Urea-Bridged Cyclic Dominant-Negative Competence-Stimulating Peptide Analogs.
    J Med Chem. 2022 Apr 22. doi: 10.1021/acs.jmedchem.2c00148.
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  36. YIN W, Wu T, Liu L, Jiang H, et al
    Species-Selective Targeting of Fungal Hsp90: Design, Synthesis, and Evaluation of Novel 4,5-Diarylisoxazole Derivatives for the Combination Treatment of Azole-Resistant Candidiasis.
    J Med Chem. 2022;65:5539-5564.
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    March 2022
  37. MA Z, He S, Yuan Y, Zhuang Z, et al
    Design, Synthesis, and Characterization of TNP-2198, a Dual-Targeted Rifamycin-Nitroimidazole Conjugate with Potent Activity against Microaerophilic and Anaerobic Bacterial Pathogens.
    J Med Chem. 2022;65:4481-4495.
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  38. KOBAURI P, Galenkamp NS, Schulte AM, de Vries J, et al
    Hypothesis-Driven, Structure-Based Design in Photopharmacology: The Case of eDHFR Inhibitors.
    J Med Chem. 2022;65:4798-4817.
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    February 2022
  39. ACEBRON-GARCIA-DE-EULATE M, Mayol-Llinas J, Holland MTO, Kim SY, et al
    Discovery of Novel Inhibitors of Uridine Diphosphate-N-Acetylenolpyruvylglucosamine Reductase (MurB) from Pseudomonas aeruginosa, an Opportunistic Infectious Agent Causing Death in Cystic Fibrosis Patients.
    J Med Chem. 2022;65:2149-2173.
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  40. MODAK B, Girkar S, Narayan R, Kapoor S, et al
    Mycobacterial Membranes as Actionable Targets for Lipid-Centric Therapy in Tuberculosis.
    J Med Chem. 2022 Feb 8. doi: 10.1021/acs.jmedchem.1c01870.
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    January 2022
  41. OTTAVI S, Scarry SM, Mosior J, Ling Y, et al
    In Vitro and In Vivo Inhibition of the Mycobacterium tuberculosis Phosphopantetheinyl Transferase PptT by Amidinoureas.
    J Med Chem. 2022 Jan 19. doi: 10.1021/acs.jmedchem.1c01565.
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  42. SHYAM M, Verma H, Bhattacharje G, Mukherjee P, et al
    Mycobactin Analogues with Excellent Pharmacokinetic Profile Demonstrate Potent Antitubercular Specific Activity and Exceptional Efflux Pump Inhibition.
    J Med Chem. 2022;65:234-256.
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  43. HU Y, Li H, Qu R, He T, et al
    Lysine Stapling Screening Provides Stable and Low Toxic Cationic Antimicrobial Peptides Combating Multidrug-Resistant Bacteria In Vitro and In Vivo.
    J Med Chem. 2022;65:579-591.
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  44. LIU J, Hou JS, Chang YQ, Peng LJ, et al
    New Pqs Quorum Sensing System Inhibitor as an Antibacterial Synergist against Multidrug-Resistant Pseudomonas aeruginosa.
    J Med Chem. 2022;65:688-709.
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  45. LEE D, Lee E, Jang S, Kim K, et al
    Discovery of Mycobacterium tuberculosis Rv3364c-Derived Small Molecules as Potential Therapeutic Agents to Target SNX9 for Sepsis.
    J Med Chem. 2022 Jan 4. doi: 10.1021/acs.jmedchem.1c01551.
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    November 2021
  46. TRAN W, Kusay AS, Hawkins PME, Cheung CY, et al
    Synthetic Sansanmycin Analogues as Potent Mycobacterium tuberculosis Translocase I Inhibitors.
    J Med Chem. 2021 Nov 30. doi: 10.1021/acs.jmedchem.1c01407.
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  47. CHOI JW, Lee KT, Kim S, Lee YR, et al
    Optimization and Evaluation of Novel Antifungal Agents for the Treatment of Fungal Infection.
    J Med Chem. 2021;64:15912-15935.
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    October 2021
  48. PRATAP VERMA D, Ansari MM, Verma NK, Saroj J, et al
    Tandem Repeat of a Short Human Chemerin-Derived Peptide and Its Nontoxic d-Lysine-Containing Enantiomer Display Broad-Spectrum Antimicrobial and Antitubercular Activities.
    J Med Chem. 2021;64:15349-15366.
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  49. FRIDIANTO KT, Li M, Hards K, Negatu DA, et al
    Functionalized Dioxonaphthoimidazoliums: A Redox Cycling Chemotype with Potent Bactericidal Activities against Mycobacterium tuberculosis.
    J Med Chem. 2021 Oct 27. doi: 10.1021/acs.jmedchem.1c01383.
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  50. CHEN Z, Song K, Shang Y, Xiong Y, et al
    Selection and Identification of Novel Antibacterial Agents against Planktonic Growth and Biofilm Formation of Enterococcus faecalis.
    J Med Chem. 2021 Oct 16. doi: 10.1021/acs.jmedchem.1c00939.
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    August 2021
  51. PEUKERT C, Langer LNB, Wegener SM, Tutov A, et al
    Optimization of Artificial Siderophores as (68)Ga-Complexed PET Tracers for In Vivo Imaging of Bacterial Infections.
    J Med Chem. 2021;64:12359-12378.
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  52. GOU S, Li B, Ouyang X, Ba Z, et al
    Novel Broad-Spectrum Antimicrobial Peptide Derived from Anoplin and Its Activity on Bacterial Pneumonia in Mice.
    J Med Chem. 2021;64:11247-11266.
    >> Share

    July 2021
  53. KATO I, Ukai Y, Kondo N, Nozu K, et al
    Identification of Thiazoyl Guanidine Derivatives as Novel Antifungal Agents Inhibiting Ergosterol Biosynthesis for Treatment of Invasive Fungal Infections.
    J Med Chem. 2021;64:10482-10496.
    >> Share


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