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Articles published in
J Med Chem
    December 2025
  1. YE J, Kan CH, Liu J, Tsang TF, et al
    Dithioether Inhibitors of Bacterial RNA Polymerase-Sigma Factor Interactions Exhibit In Vivo Efficacy against MRSA.
    J Med Chem. 2025;68:25352-25374.
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  2. KUMAR TA, Birua S, Mallojjala SC, Mukherjee P, et al
    A Mycobacteria-Specific Prodrug to Overcome Phenotypic AMR in Mycobacterium tuberculosis.
    J Med Chem. 2025 Dec 1. doi: 10.1021/acs.jmedchem.5c01848.
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    November 2025
  3. TAN YM, Wei YJ, Ahmad N, Zhang SL, et al
    Identification of Novel Benzopyridonyl Cyanovinylpyrimidines as Potential Broad-Spectrum Antibacterial Members.
    J Med Chem. 2025;68:24232-24259.
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  4. JIANG S, Zhang W, Tian L, Zeng C, et al
    Rational Leucine-Centric Design Confers Enhanced Proteolytic Stability and Reduced Toxicity of Antimicrobial Peptides against Multidrug-Resistant Bacterial Infections.
    J Med Chem. 2025;68:23006-23023.
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  5. CHAUDHARY K, Agrahari B, Sonker H, Dewan S, et al
    Discovery of Ruthenium(Arene) Metalloantibiotics: Advancing Selective and Potent Therapeutics against Gram-Negative Acinetobacter baumannii.
    J Med Chem. 2025;68:22264-22287.
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  6. DOMINGUEZ-CISNEROS H, Konai MM, Kim C, Rana N, et al
    Antibacterial Benzimidazole-2-Methanamines as Allosteric Modulators of Streptococcus pneumoniae Penicillin-Binding Protein 2x.
    J Med Chem. 2025 Nov 10. doi: 10.1021/acs.jmedchem.5c02273.
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    October 2025
  7. PODDAR SK, Dey K, Zheng G
    Harnessing Chimeric Degrader Technologies for Antimicrobial Innovation.
    J Med Chem. 2025;68:20930-20963.
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  8. KOVAR O, Kufa M, Finger V, Soukup O, et al
    Scaffold Hopping in Tuberculosis Drug Discovery: Principles, Applications, and Case Studies.
    J Med Chem. 2025 Oct 7. doi: 10.1021/acs.jmedchem.5c01100.
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    September 2025
  9. LEE JK, Lee CY, Son M, Kim B, et al
    A Novel Peptide Antibiotic Targeting Gram-Negative Infections Designed from Mycobacterium tuberculosis Adenylate Kinase.
    J Med Chem. 2025 Sep 4. doi: 10.1021/acs.jmedchem.5c01412.
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    August 2025
  10. HOLLY KJ, Tharra PR, Abutaleb NS, Nocentini A, et al
    Hit-to-Lead Optimization of Acetazolamide-Based Bacterial Carbonic Anhydrase Inhibitors with Efficacy In Vivo for Treatment of Vancomycin-Resistant Enterococci Septicemia.
    J Med Chem. 2025 Aug 29. doi: 10.1021/acs.jmedchem.5c01584.
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  11. SONKER H, Dewan S, Chaudhary K, Agrahari B, et al
    Water-Soluble Ruthenium(II) p-Cymene Complexes Mitigating Intracellular S. aureus Infection: Bridging Antibacterial Defense and Anticancer Therapy.
    J Med Chem. 2025;68:17897-17916.
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  12. DUAN M, Huang X, Qiu C, Sun L, et al
    Multiparameter Optimization of Broad-Spectrum Antibacterial Activity, ADMET Properties, and MAO-A/B Inhibition of Novel Biaryloxazolidinone-Hydrazone Derivatives: Identification of a Lead with In Vivo Efficacy against Linezolid-Resistant Staphylococcu
    J Med Chem. 2025 Aug 15. doi: 10.1021/acs.jmedchem.5c00037.
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  13. NI D, Liu G
    Iron Uptake Systems: Chemical Tools for Advancing Infectious Disease Treatment and Diagnosis.
    J Med Chem. 2025;68:15285-15338.
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  14. DAVIS SH, Mathieson M, Buchanan KI, Dawson A, et al
    Design and Development of Lysyl tRNA Synthetase Inhibitors, for the Treatment of Tuberculosis.
    J Med Chem. 2025 Aug 1. doi: 10.1021/acs.jmedchem.5c01331.
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    July 2025
  15. AMBROSIO FA, Marchese E, Listro R, Linciano P, et al
    In Silico-Guided Discovery and In Vitro Evaluation of Natural Sortase A Inhibitors to Fight Multidrug-Resistant Staphylococcus aureus.
    J Med Chem. 2025 Jul 30. doi: 10.1021/acs.jmedchem.5c01009.
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  16. LONG HZ, Tang W, Huang MY, Yang GB, et al
    Discovery of Dual-Acting Biofilm Inhibitors against Pseudomonas aeruginosa by the Coupling of 3-Hydroxypyridin-4(1H)-ones with N-Phenylamide QS Inhibitors.
    J Med Chem. 2025;68:14756-14781.
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  17. LUO J, Yin J, Xie G, Li Z, et al
    Discovery of SaClpP-Selective Imipridone Derivatives as Novel Antistaphylococcal Agents.
    J Med Chem. 2025;68:14555-14568.
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  18. KAVANAGH ME, McLean KJ, Gilbert SH, Amadi CN, et al
    Fragment-Based Development of Small Molecule Inhibitors Targeting Mycobacterium tuberculosis Cholesterol Metabolism.
    J Med Chem. 2025 Jul 13. doi: 10.1021/acs.jmedchem.5c00478.
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  19. SINGH M, Boomgaren M, Bakht P, Ihle P, et al
    Design and SAR Analysis of Phenylboronic Acid-Based Inhibitors for Sensitizing KPC-2-Producing Klebsiella pneumoniae to beta-Lactam Antibiotics.
    J Med Chem. 2025;68:13421-13435.
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    June 2025
  20. CHEN Y, Li Y, Nahar KS, Hasan MM, et al
    New Generation Modified Azole Antifungals against Multidrug-Resistant Candida auris.
    J Med Chem. 2025 Jun 23. doi: 10.1021/acs.jmedchem.5c01253.
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  21. LIN J, Yang W, Xin J, Cao H, et al
    Lead Optimization and Target Identification of Carboline Antifungal Agents.
    J Med Chem. 2025;68:11502-11515.
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  22. NEGI A, Perveen S, Kour H, Singh PP, et al
    Keeping Up with the Q's: Mechanistic Insights and Validation of Quinoline and Quinazoline Scaffolds as Potent Drugs against Tuberculosis.
    J Med Chem. 2025 Jun 10. doi: 10.1021/acs.jmedchem.4c02568.
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    May 2025
  23. SONKER H, Chaudhary K, Agrahari B, Dewan S, et al
    De Novo 3-(Phenylcarbamoyl) Benzoate Analogues: Efficacy against Multidrug-Resistant S. aureus and Elucidation of the Biodistribution Profile.
    J Med Chem. 2025;68:10329-10345.
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  24. PUJARI AK, Kirar S, Gogde K, Rawat K, et al
    Designing Lignin-Based Nanophotocomposites as Reactive Oxygen Species Generators for Inactivating Candida Strains.
    J Med Chem. 2025 May 12. doi: 10.1021/acs.jmedchem.5c00482.
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  25. ANTONINI G, Fares M, Hauck D, Mala P, et al
    Toward Dual-Target Glycomimetics against Two Bacterial Lectins to Fight Pseudomonas aeruginosa-Burkholderia cenocepacia Infections: A Biophysical Study.
    J Med Chem. 2025;68:9681-9693.
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  26. TIAN L, Wang T, Luan L, Meng Z, et al
    Terminally Symmetric beta-Turn Peptides for Multidrug-Resistant Bacterial Infections.
    J Med Chem. 2025;68:9341-9356.
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  27. HEIDTMANN CV, Fisker CD, Logstrup S, Eriksen PG, et al
    Linker and Head-Group Exploration of Anti-MRSA Triaromatic Pleuromutilins.
    J Med Chem. 2025;68:9479-9500.
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    April 2025
  28. XIE Y, Wang X, Chang T, Chen Z, et al
    Novel Aryl Sulfonium Modification on Vancomycin to Tackle MRSA and VRE In Vitro and In Vivo through Dual Enhanced Cell-Wall and Membrane Inhibition.
    J Med Chem. 2025;68:8310-8329.
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  29. LIANG T, Tu J, He Q, Zou P, et al
    Discovery of New Pyrazolone Carbothioamide Derivatives as Potent Antifungal Agents for the Treatment of Candidiasis and Cryptococcosis.
    J Med Chem. 2025;68:8439-8454.
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  30. XU T, Xue Z, Li X, Zhang M, et al
    Development of Membrane-Targeting Osthole Derivatives Containing Pyridinium Quaternary Ammonium Moieties with Potent Anti-Methicillin-Resistant Staphylococcus aureus Properties.
    J Med Chem. 2025;68:7459-7475.
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  31. LIU K, Liu Y, Wang Q, Nazare M, et al
    PaAP-Activatable NIR Probe for Diagnosing, Imaging, and Discovering Small-Molecule Therapeutics against Implant-Associated Biofilm Infections.
    J Med Chem. 2025;68:7827-7838.
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    March 2025
  32. ZHANG ZM, Zhao SY, Liu WQ, Wu X, et al
    Hybrid Molecules of Benzothiazole and Hydroxamic Acid as Dual-Acting Biofilm Inhibitors with Antibacterial Synergistic Effect against Pseudomonas aeruginosa Infections.
    J Med Chem. 2025;68:6210-6232.
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  33. HE Y, Su J, Li M, Fareed MS, et al
    Discovery of Cationic Lugdunin Derivatives with Membrane-Disrupting Activity against Resistant Bacteria via Radical Reactions and Amino Acid Mutations.
    J Med Chem. 2025;68:5699-5718.
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  34. CARDOSO J, Pinto E, Sousa E, Resende DISP, et al
    Redefining Antifungal Treatment: The Innovation of Metal-Based Compounds.
    J Med Chem. 2025;68:5006-5023.
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  35. SHARMA P, Jiang Q, Li SG, Ocke E, et al
    Evolution of Small Molecule Inhibitors of Mycobacterium tuberculosis Menaquinone Biosynthesis.
    J Med Chem. 2025 Mar 4. doi: 10.1021/acs.jmedchem.4c03156.
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  36. CAZZANIGA G, Mori M, Griego A, Scarpa E, et al
    Nanoenabling MbtI Inhibitors for Next-Generation Tuberculosis Therapy.
    J Med Chem. 2025 Mar 3. doi: 10.1021/acs.jmedchem.4c02386.
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    February 2025
  37. ZIMMERMANN T, Feng J, Fischer S, de Campos LJ, et al
    Structural Optimization of Covalent Inhibitors for Deubiquitinase ChlaDUB1 of Chlamydia trachomatis as Antibiotic Agents.
    J Med Chem. 2025 Feb 28. doi: 10.1021/acs.jmedchem.4c02464.
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  38. XU L, Wang Y, Hu S, Pei Y, et al
    Discovery of Metabolic Reprogramming 2-Quinolones as Effective Antimicrobials for MRSA-Infected Wound Therapy.
    J Med Chem. 2025;68:3004-3019.
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    January 2025
  39. LI G, Chen W, Guan H, Lai Z, et al
    Dendritic Antifungal Peptides as Potent Agents against Drug-Resistant Candida albicans and Biofilm.
    J Med Chem. 2025 Jan 27. doi: 10.1021/acs.jmedchem.4c02598.
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  40. ZHANG M, Yang W, Liu N, Tu J, et al
    Lanosterol 14alpha-Demethylase (CYP51)/Heat Shock Protein 90 (Hsp90) Dual Inhibitors for the Treatment of Invasive Candidiasis.
    J Med Chem. 2025;68:1668-1681.
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  41. YAN X, Yang C, Li B, Bian Y, et al
    Positive Charge-Concentrated Dimeric Lipopeptides with Enhanced Protease Resistance: A Potential Solution for Systemic Bacterial Infections.
    J Med Chem. 2025;68:1397-1416.
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  42. ZHANG T, Wu W, Zhao Y, Ding Z, et al
    Structure-Guided Development of ClpP Agonists with Potent Therapeutic Activities against Staphylococcus aureus Infection.
    J Med Chem. 2025 Jan 6. doi: 10.1021/acs.jmedchem.4c02562.
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    December 2024
  43. LIU X, Wang D, Wei X, Yang D, et al
    Selectively Antagonizing the NOD1-Mediated Inflammatory Signaling Pathway Mitigates the Gastric Inflammation Induced by Helicobacter pylori Infection.
    J Med Chem. 2024;67:22145-22167.
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  44. DA SILVA FF, Paz JD, Rambo RS, Goncalves GA, et al
    Unveiling the Antimycobacterial Potential of Novel 4-Alkoxyquinolines: Insights into Selectivity, Mechanism of Action, and In Vivo Exposure.
    J Med Chem. 2024;67:21781-21794.
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  45. RANI N, Rajmani RS, Surolia A
    Identification of an Isoxazole Derivative as an Antitubercular Compound for Targeting the FadD Enzymes of Mycobacterium tuberculosis.
    J Med Chem. 2024 Dec 18. doi: 10.1021/acs.jmedchem.4c01844.
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  46. LIU K, Xia J, Li Y, Li BB, et al
    Discovery of Novel Coumarin Pleuromutilin Derivatives as Potent Anti-MRSA Agents.
    J Med Chem. 2024;67:21030-21048.
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  47. BERIDA T, Lindsley CW
    Move over COVID, Tuberculosis Is Once again the Leading Cause of Death from a Single Infectious Disease.
    J Med Chem. 2024 Dec 9. doi: 10.1021/acs.jmedchem.4c02876.
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    November 2024
  48. LIU JJ, Liu J, Huang YS, Chen WM, et al
    Cyclic Diguanylate G-Quadruplex Inducer-Quorum Sensing Inhibitor Hybrids as Bifunctional Anti-biofilm and Anti-virulence Agents Against Pseudomonas aeruginosa.
    J Med Chem. 2024;67:18911-18929.
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    October 2024
  49. YAN D, Kong H, Qu Y, Li R, et al
    Development of Phloroglucinol-Linked Tris-Quaternary Ammonium Salt Antimicrobial Peptide Mimics with Low Cytotoxicity and Broad-Spectrum Antibacterial Activity.
    J Med Chem. 2024;67:18576-18592.
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    September 2024
  50. MIAO ZY, Zhang XY, Long HZ, Lin J, et al
    Hybrids of 3-Hydroxypyridin-4(1H)-ones and Long-Chain 4-Aminoquinolines as Potent Biofilm Inhibitors of Pseudomonas aeruginosa Potentiate Tobramycin and Polymyxin B Activity.
    J Med Chem. 2024;67:16835-16857.
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  51. MAJI S, Akhtar S, Halder S, Chatterjee I, et al
    Corannulene Amino Acid-Derived Water-Soluble Amphiphilic Buckybowls as Broad-Spectrum Membrane Targeting Antibacterial Agents.
    J Med Chem. 2024;67:15041-15060.
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  52. SKUDLAREK JW, Cooke AJ, Mitchell HJ, Babaoglu K, et al
    Cerastecin Inhibition of the Lipooligosaccharide Transporter MsbA to Combat Acinetobacter baumannii: From Screening Impurity to In Vivo Efficacy.
    J Med Chem. 2024;67:15620-15675.
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  53. YOUSE MS, Abutaleb NS, Nocentini A, S Abdelsattar A, et al
    Optimization of Ethoxzolamide Analogs with Improved Pharmacokinetic Properties for In Vivo Efficacy against Neisseria gonorrhoeae.
    J Med Chem. 2024;67:15537-15556.
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  54. YANG R, Cui L, Xu S, Zhong Y, et al
    Membrane-Targeting Amphiphilic Honokiol Derivatives Containing an Oxazole Moiety as Potential Antibacterials against Methicillin-Resistant Staphylococcus aureus.
    J Med Chem. 2024 Sep 11. doi: 10.1021/acs.jmedchem.4c01860.
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    August 2024
  55. LI K, Tolentino Collado J, Marden JA, Pollard AC, et al
    Biological Evaluation of d-[(18)F]Fluoroalanine and d-[(18)F]Fluoroalanine-d(3) as Positron Emission Tomography Imaging Tracers for Bacterial Infection.
    J Med Chem. 2024;67:13975-13984.
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  56. CHARRIA-GIRON E, Zeng H, Gorelik TE, Pahl A, et al
    Arcopilins: A New Family of Staphylococcus aureus Biofilm Disruptors from the Soil Fungus Arcopilus navicularis.
    J Med Chem. 2024 Aug 14. doi: 10.1021/acs.jmedchem.4c00585.
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  57. PELLICCIA S, Russomanno P, Barone S, Mateu B, et al
    A First-in-Class Pyrazole-isoxazole Enhanced Antifungal Activity of Voriconazole: Synergy Studies in an Azole-Resistant Candida albicans Strain, Computational Investigation and in Vivo Validation in a Galleria mellonella Fungal Infection Model.
    J Med Chem. 2024 Aug 8. doi: 10.1021/acs.jmedchem.4c01109.
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  58. YAN Z, Li Q, Li X, Wang H, et al
    Discovery of Novel alpha,beta-Unsaturated Amide Derivatives as Candidate Antifungals to Overcome Fungal Resistance.
    J Med Chem. 2024;67:12601-12617.
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    July 2024
  59. YU Z, Liang YC, Berton S, Liu L, et al
    Small Molecule Targeting PPM1A Activates Autophagy for Mycobacterium tuberculosis Host-Directed Therapy.
    J Med Chem. 2024 Jul 3. doi: 10.1021/acs.jmedchem.4c00513.
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    June 2024
  60. ZHANG L, Yang J, Xu X, Zhang J, et al
    Discovery and Optimization of Novel SaFabI Inhibitors as Specific Therapeutic Agents for MRSA Infection.
    J Med Chem. 2024;67:10096-10134.
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  61. MULAR A, Hubmann I, Petrik M, Bendova K, et al
    Biomimetic Analogues of the Desferrioxamine E Siderophore for PET Imaging of Invasive Aspergillosis: Targeting Properties and Species Specificity.
    J Med Chem. 2024 Jun 22. doi: 10.1021/acs.jmedchem.4c00887.
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  62. ZIMMERMANN T, Feng J, de Campos LJ, Knight LA, et al
    Structure-Based Design and Synthesis of Covalent Inhibitors for Deubiquitinase and Acetyltransferase ChlaDUB1 of Chlamydia trachomatis.
    J Med Chem. 2024 Jun 19. doi: 10.1021/acs.jmedchem.4c00230.
    >> Share

  63. RUEEDI G, Panchaud P, Friedli A, Specklin JL, et al
    Discovery and Structure-Activity Relationship of Cadazolid: A First-In-Class Quinoxolidinone Antibiotic for the Treatment of Clostridioides difficile Infection.
    J Med Chem. 2024;67:9465-9484.
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    May 2024
  64. YU S, He YQ, Liu Y, Ji S, et al
    Construction and Activity Evaluation of Novel Bifunctional Inhibitors and a COF Carrier Based on a Fungal Infection Microenvironment.
    J Med Chem. 2024;67:8420-8444.
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  65. WANG X, Jin X, Zhao F, Xu Z, et al
    Structure-Based Optimization of Novel Sterol 24-C-Methyltransferase Inhibitors for the Treatment of Candida albicans Infections.
    J Med Chem. 2024 May 19. doi: 10.1021/acs.jmedchem.4c00470.
    >> Share

  66. HE Y, Ruan S, Liang G, Hao J, et al
    A Nonbactericidal Anionic Antimicrobial Peptide Provides Prophylactic and Therapeutic Efficacies against Bacterial Infections in Mice by Immunomodulatory-Antithrombotic Duality.
    J Med Chem. 2024;67:7487-7503.
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    April 2024
  67. NI T, Hao Y, Ding Z, Chi X, et al
    Discovery of a Novel Potent Tetrazole Antifungal Candidate with High Selectivity and Broad Spectrum.
    J Med Chem. 2024;67:6238-6252.
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    March 2024
  68. YANG W, Liu R, Li Z, Tu J, et al
    Discovery of New Tricyclic Oxime Sampangine Derivatives as Potent Antifungal Agents for the Treatment of Cryptococcosis and Candidiasis.
    J Med Chem. 2024;67:4726-4738.
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  69. MUSZALSKA-KOLOS I, Dwiecki PM
    Searching for Conjugates as New Structures for Antifungal Therapies.
    J Med Chem. 2024;67:4298-4321.
    >> Share

  70. FRANCO AR, Sadones O, Romerio A, Artusa V, et al
    Novel TLR4-Activating Vaccine Adjuvant Enhances the Production of Enterococcus faecium-binding Antibodies.
    J Med Chem. 2024 Mar 21. doi: 10.1021/acs.jmedchem.3c02215.
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  71. XU T, Yan X, Kang A, Yang L, et al
    Development of Membrane-Targeting Fluorescent 2-Phenyl-1H-phenanthro[9,10-d]imidazole-Antimicrobial Peptide Mimic Conjugates against Methicillin-Resistant Staphylococcus aureus.
    J Med Chem. 2024 Mar 16. doi: 10.1021/acs.jmedchem.4c00436.
    >> Share

  72. HEIDTMANN CV, Fejer AR, Staerk K, Pedersen M, et al
    Hit-to-Lead Identification and Validation of a Triaromatic Pleuromutilin Antibiotic Candidate.
    J Med Chem. 2024;67:3692-3710.
    >> Share

  73. XIE F, Hao Y, Liu Y, Bao J, et al
    From Synergy to Monotherapy: Discovery of Novel 2,4,6-Trisubstituted Triazine Hydrazone Derivatives with Potent Antifungal Potency In Vitro and In Vivo.
    J Med Chem. 2024;67:4007-4025.
    >> Share

  74. HUANG Z, Gou X, Hang X, Shi T, et al
    Design, Synthesis, and Biological Evaluation of 5-(5-Iodo-2-isopropyl-4-methoxyphenoxy)pyrimidine-2,4-diamine (AF-353) Derivatives as Novel DHFR Inhibitors against Staphylococcus aureus.
    J Med Chem. 2024 Mar 11. doi: 10.1021/acs.jmedchem.3c02355.
    >> Share

    February 2024
  75. MADDIRALA AR, Pinkner JS, Tamadonfar K, Sanick D, et al
    Discovery of Orally Bioavailable FmlH Lectin Antagonists as Treatment for Urinary Tract Infections.
    J Med Chem. 2024 Feb 3. doi: 10.1021/acs.jmedchem.3c02128.
    >> Share


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