Amedeo Smart

Free Medical Literature Service

 

Amedeo

Bacterial Infections and Mycoses
  Free Subscription

Articles published in
J Med Chem
    June 2025
  1. LIN J, Yang W, Xin J, Cao H, et al
    Lead Optimization and Target Identification of Carboline Antifungal Agents.
    J Med Chem. 2025;68:11502-11515.
    >> Share

  2. NEGI A, Perveen S, Kour H, Singh PP, et al
    Keeping Up with the Q's: Mechanistic Insights and Validation of Quinoline and Quinazoline Scaffolds as Potent Drugs against Tuberculosis.
    J Med Chem. 2025 Jun 10. doi: 10.1021/acs.jmedchem.4c02568.
    >> Share

    May 2025
  3. SONKER H, Chaudhary K, Agrahari B, Dewan S, et al
    De Novo 3-(Phenylcarbamoyl) Benzoate Analogues: Efficacy against Multidrug-Resistant S. aureus and Elucidation of the Biodistribution Profile.
    J Med Chem. 2025;68:10329-10345.
    >> Share

  4. PUJARI AK, Kirar S, Gogde K, Rawat K, et al
    Designing Lignin-Based Nanophotocomposites as Reactive Oxygen Species Generators for Inactivating Candida Strains.
    J Med Chem. 2025 May 12. doi: 10.1021/acs.jmedchem.5c00482.
    >> Share

  5. ANTONINI G, Fares M, Hauck D, Mala P, et al
    Toward Dual-Target Glycomimetics against Two Bacterial Lectins to Fight Pseudomonas aeruginosa-Burkholderia cenocepacia Infections: A Biophysical Study.
    J Med Chem. 2025;68:9681-9693.
    >> Share

  6. TIAN L, Wang T, Luan L, Meng Z, et al
    Terminally Symmetric beta-Turn Peptides for Multidrug-Resistant Bacterial Infections.
    J Med Chem. 2025;68:9341-9356.
    >> Share

  7. HEIDTMANN CV, Fisker CD, Logstrup S, Eriksen PG, et al
    Linker and Head-Group Exploration of Anti-MRSA Triaromatic Pleuromutilins.
    J Med Chem. 2025;68:9479-9500.
    >> Share

    April 2025
  8. XIE Y, Wang X, Chang T, Chen Z, et al
    Novel Aryl Sulfonium Modification on Vancomycin to Tackle MRSA and VRE In Vitro and In Vivo through Dual Enhanced Cell-Wall and Membrane Inhibition.
    J Med Chem. 2025;68:8310-8329.
    >> Share

  9. LIANG T, Tu J, He Q, Zou P, et al
    Discovery of New Pyrazolone Carbothioamide Derivatives as Potent Antifungal Agents for the Treatment of Candidiasis and Cryptococcosis.
    J Med Chem. 2025;68:8439-8454.
    >> Share

  10. XU T, Xue Z, Li X, Zhang M, et al
    Development of Membrane-Targeting Osthole Derivatives Containing Pyridinium Quaternary Ammonium Moieties with Potent Anti-Methicillin-Resistant Staphylococcus aureus Properties.
    J Med Chem. 2025;68:7459-7475.
    >> Share

  11. LIU K, Liu Y, Wang Q, Nazare M, et al
    PaAP-Activatable NIR Probe for Diagnosing, Imaging, and Discovering Small-Molecule Therapeutics against Implant-Associated Biofilm Infections.
    J Med Chem. 2025;68:7827-7838.
    >> Share

    March 2025
  12. ZHANG ZM, Zhao SY, Liu WQ, Wu X, et al
    Hybrid Molecules of Benzothiazole and Hydroxamic Acid as Dual-Acting Biofilm Inhibitors with Antibacterial Synergistic Effect against Pseudomonas aeruginosa Infections.
    J Med Chem. 2025;68:6210-6232.
    >> Share

  13. HE Y, Su J, Li M, Fareed MS, et al
    Discovery of Cationic Lugdunin Derivatives with Membrane-Disrupting Activity against Resistant Bacteria via Radical Reactions and Amino Acid Mutations.
    J Med Chem. 2025;68:5699-5718.
    >> Share

  14. CARDOSO J, Pinto E, Sousa E, Resende DISP, et al
    Redefining Antifungal Treatment: The Innovation of Metal-Based Compounds.
    J Med Chem. 2025;68:5006-5023.
    >> Share

  15. SHARMA P, Jiang Q, Li SG, Ocke E, et al
    Evolution of Small Molecule Inhibitors of Mycobacterium tuberculosis Menaquinone Biosynthesis.
    J Med Chem. 2025 Mar 4. doi: 10.1021/acs.jmedchem.4c03156.
    >> Share

  16. CAZZANIGA G, Mori M, Griego A, Scarpa E, et al
    Nanoenabling MbtI Inhibitors for Next-Generation Tuberculosis Therapy.
    J Med Chem. 2025 Mar 3. doi: 10.1021/acs.jmedchem.4c02386.
    >> Share

    February 2025
  17. ZIMMERMANN T, Feng J, Fischer S, de Campos LJ, et al
    Structural Optimization of Covalent Inhibitors for Deubiquitinase ChlaDUB1 of Chlamydia trachomatis as Antibiotic Agents.
    J Med Chem. 2025 Feb 28. doi: 10.1021/acs.jmedchem.4c02464.
    >> Share

  18. XU L, Wang Y, Hu S, Pei Y, et al
    Discovery of Metabolic Reprogramming 2-Quinolones as Effective Antimicrobials for MRSA-Infected Wound Therapy.
    J Med Chem. 2025;68:3004-3019.
    >> Share

    January 2025
  19. LI G, Chen W, Guan H, Lai Z, et al
    Dendritic Antifungal Peptides as Potent Agents against Drug-Resistant Candida albicans and Biofilm.
    J Med Chem. 2025 Jan 27. doi: 10.1021/acs.jmedchem.4c02598.
    >> Share

  20. ZHANG M, Yang W, Liu N, Tu J, et al
    Lanosterol 14alpha-Demethylase (CYP51)/Heat Shock Protein 90 (Hsp90) Dual Inhibitors for the Treatment of Invasive Candidiasis.
    J Med Chem. 2025;68:1668-1681.
    >> Share

  21. YAN X, Yang C, Li B, Bian Y, et al
    Positive Charge-Concentrated Dimeric Lipopeptides with Enhanced Protease Resistance: A Potential Solution for Systemic Bacterial Infections.
    J Med Chem. 2025;68:1397-1416.
    >> Share

  22. ZHANG T, Wu W, Zhao Y, Ding Z, et al
    Structure-Guided Development of ClpP Agonists with Potent Therapeutic Activities against Staphylococcus aureus Infection.
    J Med Chem. 2025 Jan 6. doi: 10.1021/acs.jmedchem.4c02562.
    >> Share

    December 2024
  23. LIU X, Wang D, Wei X, Yang D, et al
    Selectively Antagonizing the NOD1-Mediated Inflammatory Signaling Pathway Mitigates the Gastric Inflammation Induced by Helicobacter pylori Infection.
    J Med Chem. 2024;67:22145-22167.
    >> Share

  24. DA SILVA FF, Paz JD, Rambo RS, Goncalves GA, et al
    Unveiling the Antimycobacterial Potential of Novel 4-Alkoxyquinolines: Insights into Selectivity, Mechanism of Action, and In Vivo Exposure.
    J Med Chem. 2024;67:21781-21794.
    >> Share

  25. RANI N, Rajmani RS, Surolia A
    Identification of an Isoxazole Derivative as an Antitubercular Compound for Targeting the FadD Enzymes of Mycobacterium tuberculosis.
    J Med Chem. 2024 Dec 18. doi: 10.1021/acs.jmedchem.4c01844.
    >> Share

  26. LIU K, Xia J, Li Y, Li BB, et al
    Discovery of Novel Coumarin Pleuromutilin Derivatives as Potent Anti-MRSA Agents.
    J Med Chem. 2024;67:21030-21048.
    >> Share

  27. BERIDA T, Lindsley CW
    Move over COVID, Tuberculosis Is Once again the Leading Cause of Death from a Single Infectious Disease.
    J Med Chem. 2024 Dec 9. doi: 10.1021/acs.jmedchem.4c02876.
    >> Share

    November 2024
  28. LIU JJ, Liu J, Huang YS, Chen WM, et al
    Cyclic Diguanylate G-Quadruplex Inducer-Quorum Sensing Inhibitor Hybrids as Bifunctional Anti-biofilm and Anti-virulence Agents Against Pseudomonas aeruginosa.
    J Med Chem. 2024;67:18911-18929.
    >> Share

    October 2024
  29. YAN D, Kong H, Qu Y, Li R, et al
    Development of Phloroglucinol-Linked Tris-Quaternary Ammonium Salt Antimicrobial Peptide Mimics with Low Cytotoxicity and Broad-Spectrum Antibacterial Activity.
    J Med Chem. 2024;67:18576-18592.
    >> Share

    September 2024
  30. MIAO ZY, Zhang XY, Long HZ, Lin J, et al
    Hybrids of 3-Hydroxypyridin-4(1H)-ones and Long-Chain 4-Aminoquinolines as Potent Biofilm Inhibitors of Pseudomonas aeruginosa Potentiate Tobramycin and Polymyxin B Activity.
    J Med Chem. 2024;67:16835-16857.
    >> Share

  31. MAJI S, Akhtar S, Halder S, Chatterjee I, et al
    Corannulene Amino Acid-Derived Water-Soluble Amphiphilic Buckybowls as Broad-Spectrum Membrane Targeting Antibacterial Agents.
    J Med Chem. 2024;67:15041-15060.
    >> Share

  32. SKUDLAREK JW, Cooke AJ, Mitchell HJ, Babaoglu K, et al
    Cerastecin Inhibition of the Lipooligosaccharide Transporter MsbA to Combat Acinetobacter baumannii: From Screening Impurity to In Vivo Efficacy.
    J Med Chem. 2024;67:15620-15675.
    >> Share

  33. YOUSE MS, Abutaleb NS, Nocentini A, S Abdelsattar A, et al
    Optimization of Ethoxzolamide Analogs with Improved Pharmacokinetic Properties for In Vivo Efficacy against Neisseria gonorrhoeae.
    J Med Chem. 2024;67:15537-15556.
    >> Share

  34. YANG R, Cui L, Xu S, Zhong Y, et al
    Membrane-Targeting Amphiphilic Honokiol Derivatives Containing an Oxazole Moiety as Potential Antibacterials against Methicillin-Resistant Staphylococcus aureus.
    J Med Chem. 2024 Sep 11. doi: 10.1021/acs.jmedchem.4c01860.
    >> Share

    August 2024
  35. LI K, Tolentino Collado J, Marden JA, Pollard AC, et al
    Biological Evaluation of d-[(18)F]Fluoroalanine and d-[(18)F]Fluoroalanine-d(3) as Positron Emission Tomography Imaging Tracers for Bacterial Infection.
    J Med Chem. 2024;67:13975-13984.
    >> Share

  36. CHARRIA-GIRON E, Zeng H, Gorelik TE, Pahl A, et al
    Arcopilins: A New Family of Staphylococcus aureus Biofilm Disruptors from the Soil Fungus Arcopilus navicularis.
    J Med Chem. 2024 Aug 14. doi: 10.1021/acs.jmedchem.4c00585.
    >> Share

  37. PELLICCIA S, Russomanno P, Barone S, Mateu B, et al
    A First-in-Class Pyrazole-isoxazole Enhanced Antifungal Activity of Voriconazole: Synergy Studies in an Azole-Resistant Candida albicans Strain, Computational Investigation and in Vivo Validation in a Galleria mellonella Fungal Infection Model.
    J Med Chem. 2024 Aug 8. doi: 10.1021/acs.jmedchem.4c01109.
    >> Share

  38. YAN Z, Li Q, Li X, Wang H, et al
    Discovery of Novel alpha,beta-Unsaturated Amide Derivatives as Candidate Antifungals to Overcome Fungal Resistance.
    J Med Chem. 2024;67:12601-12617.
    >> Share

    July 2024
  39. YU Z, Liang YC, Berton S, Liu L, et al
    Small Molecule Targeting PPM1A Activates Autophagy for Mycobacterium tuberculosis Host-Directed Therapy.
    J Med Chem. 2024 Jul 3. doi: 10.1021/acs.jmedchem.4c00513.
    >> Share

    June 2024
  40. ZHANG L, Yang J, Xu X, Zhang J, et al
    Discovery and Optimization of Novel SaFabI Inhibitors as Specific Therapeutic Agents for MRSA Infection.
    J Med Chem. 2024;67:10096-10134.
    >> Share

  41. MULAR A, Hubmann I, Petrik M, Bendova K, et al
    Biomimetic Analogues of the Desferrioxamine E Siderophore for PET Imaging of Invasive Aspergillosis: Targeting Properties and Species Specificity.
    J Med Chem. 2024 Jun 22. doi: 10.1021/acs.jmedchem.4c00887.
    >> Share

  42. ZIMMERMANN T, Feng J, de Campos LJ, Knight LA, et al
    Structure-Based Design and Synthesis of Covalent Inhibitors for Deubiquitinase and Acetyltransferase ChlaDUB1 of Chlamydia trachomatis.
    J Med Chem. 2024 Jun 19. doi: 10.1021/acs.jmedchem.4c00230.
    >> Share

  43. RUEEDI G, Panchaud P, Friedli A, Specklin JL, et al
    Discovery and Structure-Activity Relationship of Cadazolid: A First-In-Class Quinoxolidinone Antibiotic for the Treatment of Clostridioides difficile Infection.
    J Med Chem. 2024;67:9465-9484.
    >> Share

    May 2024
  44. YU S, He YQ, Liu Y, Ji S, et al
    Construction and Activity Evaluation of Novel Bifunctional Inhibitors and a COF Carrier Based on a Fungal Infection Microenvironment.
    J Med Chem. 2024;67:8420-8444.
    >> Share

  45. WANG X, Jin X, Zhao F, Xu Z, et al
    Structure-Based Optimization of Novel Sterol 24-C-Methyltransferase Inhibitors for the Treatment of Candida albicans Infections.
    J Med Chem. 2024 May 19. doi: 10.1021/acs.jmedchem.4c00470.
    >> Share

  46. HE Y, Ruan S, Liang G, Hao J, et al
    A Nonbactericidal Anionic Antimicrobial Peptide Provides Prophylactic and Therapeutic Efficacies against Bacterial Infections in Mice by Immunomodulatory-Antithrombotic Duality.
    J Med Chem. 2024;67:7487-7503.
    >> Share

    April 2024
  47. NI T, Hao Y, Ding Z, Chi X, et al
    Discovery of a Novel Potent Tetrazole Antifungal Candidate with High Selectivity and Broad Spectrum.
    J Med Chem. 2024;67:6238-6252.
    >> Share

    March 2024
  48. YANG W, Liu R, Li Z, Tu J, et al
    Discovery of New Tricyclic Oxime Sampangine Derivatives as Potent Antifungal Agents for the Treatment of Cryptococcosis and Candidiasis.
    J Med Chem. 2024;67:4726-4738.
    >> Share

  49. MUSZALSKA-KOLOS I, Dwiecki PM
    Searching for Conjugates as New Structures for Antifungal Therapies.
    J Med Chem. 2024;67:4298-4321.
    >> Share

  50. FRANCO AR, Sadones O, Romerio A, Artusa V, et al
    Novel TLR4-Activating Vaccine Adjuvant Enhances the Production of Enterococcus faecium-binding Antibodies.
    J Med Chem. 2024 Mar 21. doi: 10.1021/acs.jmedchem.3c02215.
    >> Share

  51. XU T, Yan X, Kang A, Yang L, et al
    Development of Membrane-Targeting Fluorescent 2-Phenyl-1H-phenanthro[9,10-d]imidazole-Antimicrobial Peptide Mimic Conjugates against Methicillin-Resistant Staphylococcus aureus.
    J Med Chem. 2024 Mar 16. doi: 10.1021/acs.jmedchem.4c00436.
    >> Share

  52. HEIDTMANN CV, Fejer AR, Staerk K, Pedersen M, et al
    Hit-to-Lead Identification and Validation of a Triaromatic Pleuromutilin Antibiotic Candidate.
    J Med Chem. 2024;67:3692-3710.
    >> Share

  53. XIE F, Hao Y, Liu Y, Bao J, et al
    From Synergy to Monotherapy: Discovery of Novel 2,4,6-Trisubstituted Triazine Hydrazone Derivatives with Potent Antifungal Potency In Vitro and In Vivo.
    J Med Chem. 2024;67:4007-4025.
    >> Share

  54. HUANG Z, Gou X, Hang X, Shi T, et al
    Design, Synthesis, and Biological Evaluation of 5-(5-Iodo-2-isopropyl-4-methoxyphenoxy)pyrimidine-2,4-diamine (AF-353) Derivatives as Novel DHFR Inhibitors against Staphylococcus aureus.
    J Med Chem. 2024 Mar 11. doi: 10.1021/acs.jmedchem.3c02355.
    >> Share

    February 2024
  55. MADDIRALA AR, Pinkner JS, Tamadonfar K, Sanick D, et al
    Discovery of Orally Bioavailable FmlH Lectin Antagonists as Treatment for Urinary Tract Infections.
    J Med Chem. 2024 Feb 3. doi: 10.1021/acs.jmedchem.3c02128.
    >> Share


Free Medical Abstracts
Privacy Policy
Sponsors
Share

© Amedeo 1997-2016