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Articles published in
J Clin Invest
    November 2025
  1. CASADEVALL A
    Fungal vaccines: so needed, so feasible, and yet so far off.
    J Clin Invest. 2025;135:e199451.
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  2. OKAA UJ, Ledesma Taira C, Dos Santos Dias L, Dobson H, et al
    Endoglucanase 2 (Eng2), a shared immunodominant antigen in dimorphic fungi that elicits immunity during infection.
    J Clin Invest. 2025;135:e191103.
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    October 2025
  3. BAGOOD MD, Marjanovic J, Jiang N, Chan H, et al
    Staphylococcus aureus accessory gene regulator quorum-sensing system inhibits keratinocyte lipid enzymes and delays wound repair.
    J Clin Invest. 2025;135:e190411.
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  4. WANG M, Chu X, Fan Z, Chen L, et al
    Macrophage transition to a myofibroblast state drives fibrotic disease in uropathogenic E. coli-induced epididymo-orchitis.
    J Clin Invest. 2025;135:e193793.
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    September 2025
  5. CHO JS, Pietras EM, Garcia NC, Ramos RI, et al
    Corrigendum to IL-17 is essential for host defense against cutaneous Staphylococcus aureus infection in mice.
    J Clin Invest. 2025;135:e198106.
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  6. PAN Y, Shen L, Wu Z, Wang X, et al
    Hepcidin sustains Kupffer cell immune defense against bloodstream bacterial infection via gut-derived metabolites in mice.
    J Clin Invest. 2025;135:e189607.
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  7. ANDRADE PR, Ma F, Lu J, de Anda J, et al
    Dynamics of Th1/Th17 responses and antimicrobial pathways in leprosy skin lesions.
    J Clin Invest. 2025;135:e190736.
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    August 2025
  8. MILLER LM, Duray AM, Cipolla EM, Rago F, et al
    B cell deficiency induces cytotoxic memory CD8+ T cells during influenza-associated bacterial pneumonia.
    J Clin Invest. 2025;135:e188342.
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  9. GUO Y, Aufiero MA, Mills KA, Grassmann SA, et al
    An IFN/STAT1/CYBB Axis Defines Protective Plasmacytoid DC to Neutrophil Crosstalk in Aspergillus fumigatus - Infected mice.
    J Clin Invest. 2025 Aug 5:e190107. doi: 10.1172/JCI190107.
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    July 2025
  10. ULRICH RJ, Podkowik M, Tierce R, Irnov I, et al
    Prophage-encoded methyltransferase drives adaptation of community-acquired methicillin-resistant Staphylococcus aureus.
    J Clin Invest. 2025 Jul 22:e177872. doi: 10.1172/JCI177872.
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  11. LI J, Xie S, Chen M, Hong C, et al
    Panose prevents acute-on-chronic liver failure by reducing bacterial infection in mice.
    J Clin Invest. 2025;135:e184653.
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    June 2025
  12. KUMARASWAMY M, Riestra AM, Flores A, Dahesh S, et al
    Colistin exerts potent activity against mcr+ Enterobacteriaceae via synergistic interactions with the host defense.
    J Clin Invest. 2025;135:e170690.
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  13. GILBERT NM, Ramirez Hernandez LA, Berman D, Morrill S, et al
    Social, microbial, and immune factors linking bacterial vaginosis and infectious diseases.
    J Clin Invest. 2025;135:e184322.
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    May 2025
  14. IVIE JJ, Dill-McFarland KA, Simmons JD, Peterson GJ, et al
    Myeloid cell genome-wide screen identifies variants associated with Mycobacterium tuberculosis-induced cytokine transcriptional responses.
    J Clin Invest. 2025 May 22:e179822. doi: 10.1172/JCI179822.
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  15. HUY TXN, Hop HT
    Mycobacterium tuberculosis hijacks the UBE2O pathway to regulate host iron homeostasis.
    J Clin Invest. 2025;135:e184095.
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  16. NAZ F, Uddin MJ, Hagspiel N, Young MK, et al
    IL-33 protects from recurrent C. difficile infection by restoration of humoral immunity.
    J Clin Invest. 2025;135:e184659.
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    April 2025
  17. MISHRA B, Basu A, Shehadeh F, Felix L, et al
    Antimicrobial Peptide Developed with Machine Learning Sequence Optimization Targets Drug Resistant Staphylococcus aureus in Mice.
    J Clin Invest. 2025 Apr 22:e185430. doi: 10.1172/JCI185430.
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  18. PELLEGRINI JM, Keriel A, Gorvel L, Hanniffy S, et al
    SLAMF7 and SLAMF8 receptors shape human plasmacytoid dendritic cell responses to intracellular bacteria.
    J Clin Invest. 2025;135:e182467.
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  19. YOUNGQUIST BM, Mnguni AT, Pungan D, Lai RP, et al
    CRISPR-mediated detection of Pneumocystis transcripts in bronchoalveolar, oropharyngeal, and serum specimens for Pneumocystis pneumonia diagnosis.
    J Clin Invest. 2025;135:e177241.
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  20. SETIABUDIAWAN TP, Hill PC, DiNardo AR, van Crevel R, et al
    Insights into protection against Mycobacterium tuberculosis infection: time to officially confirm another phenotype?
    J Clin Invest. 2025;135:e191423.
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    March 2025
  21. MACLEAN F, Tsegaye AT, Graham JB, Swarts JL, et al
    Bacterial vaginosis associates with dysfunctional T cells and altered soluble immune factors in the cervicovaginal tract.
    J Clin Invest. 2025 Mar 25:e184609. doi: 10.1172/JCI184609.
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  22. ALMEIDA CF, Juno JA
    Sensing mycobacteria through unconventional pathways.
    J Clin Invest. 2025;135:e190230.
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  23. KIM MK, Suh GA, Cullen GD, Perez Rodriguez S, et al
    Bacteriophage therapy for multidrug-resistant infections: current technologies and therapeutic approaches.
    J Clin Invest. 2025;135:e187996.
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    January 2025
  24. DALLMANN-SAUER M, Fava VM, Malherbe ST, MacDonald CE, et al
    Mycobacterium tuberculosis resisters despite HIV exhibit activated T cells and macrophages in their pulmonary alveoli.
    J Clin Invest. 2025 Jan 21:e188016. doi: 10.1172/JCI188016.
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    December 2024
  25. SAKAI Y, Asa M, Hirose M, Kusuhara W, et al
    A conserved human CD4+ T cell subset recognizing the mycobacterial adjuvant trehalose monomycolate.
    J Clin Invest. 2024;135:e185443.
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  26. TORRES VJ
    Interleukin 10 drives Staphylococcus aureus imprinting and vaccine failure in murine models via antibody glycosylation.
    J Clin Invest. 2024;134:e187055.
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  27. TSAI CM, Hajam IA, Caldera JR, Chiang AW, et al
    Pathobiont-driven antibody sialylation through IL-10 undermines vaccination.
    J Clin Invest. 2024;134:e179563.
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  28. WANG Q, Hu T, Zhang Q, Zhang Y, et al
    Fusobacterium nucleatum promotes colorectal cancer through neogenesis of tumor stem cells.
    J Clin Invest. 2024 Dec 10:e181595. doi: 10.1172/JCI181595.
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    November 2024
  29. DAI Y, Edwards VL, Yu Q, Tettelin H, et al
    Neisseria gonorrhoeae induces local secretion of IL-10 at the human cervix to promote colonization.
    J Clin Invest. 2024;135:e183331.
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    October 2024
  30. CHAMBERS HF, Fowler VG Jr
    Intertwining clonality and resistance: Staphylococcus aureus in the antibiotic era.
    J Clin Invest. 2024;134:e185824.
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    September 2024
  31. SANCHES SANTOS RIZZO ZUTTION M, Parimon T, Bora SA, Yao C, et al
    Antibiotic use during influenza infection augments lung eosinophils that impair immunity against secondary bacterial pneumonia.
    J Clin Invest. 2024;134:e180986.
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  32. MORGAN SJ, Coulter E, Betts HL, Solomon GM, et al
    Elexacaftor/tezacaftor/ivacaftor's effects on cystic fibrosis infections are maintained, but not increased, after 3.5 years of treatment.
    J Clin Invest. 2024;134:e184171.
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  33. STEERE AC, Lemieux JE
    Wider recognition and greater understanding of postinfectious, antibiotic-refractory Lyme arthritis.
    J Clin Invest. 2024;134:e184109.
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    August 2024
  34. BATH J, Bjanes E, Goekeri C, Hsiao J, et al
    Mucins protect against Streptococcus pneumoniae virulence by suppressing pneumolysin expression.
    J Clin Invest. 2024 Aug 22:e182769. doi: 10.1172/JCI182769.
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  35. AL-AWQATI Q
    The forgotten pandemic: how understanding cholera illuminated mechanisms of chloride channels in multiple diseases.
    J Clin Invest. 2024;134:e184297.
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    July 2024
  36. DIRKS J, Fischer J, Klaussner J, Hofmann C, et al
    Disease-specific T cell receptors maintain pathogenic T helper cell responses in postinfectious Lyme arthritis.
    J Clin Invest. 2024;134:e179391.
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    June 2024
  37. BOU GHANEM EN
    CHIPing away at immunity: the role of clonal hematopoiesis of indeterminate potential in bacterial pneumonia.
    J Clin Invest. 2024;134:e181064.
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    May 2024
  38. DESAI JV, Zarakas MA, Wishart AL, Roschewski M, et al
    BTK drives neutrophil activation for sterilizing antifungal immunity.
    J Clin Invest. 2024;134:e176142.
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  39. BISHU S, Kao JY
    A step closer to understanding how a diet high in simple carbohydrates may cause dysbiosis.
    J Clin Invest. 2024;134:e180001.
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    April 2024
  40. QUIN C, DeJong EN, Cook EK, Luo YZ, et al
    Neutrophil-mediated innate immune resistance to bacterial pneumonia is dependent on Tet2 function.
    J Clin Invest. 2024;134:e171002.
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    March 2024
  41. HECHT AL, Harling LC, Friedman ES, Tanes C, et al
    Dietary carbohydrates regulate intestinal colonization and dissemination of Klebsiella pneumoniae.
    J Clin Invest. 2024;134:e174726.
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  42. PEEL JN, Yang R, Le Voyer T, Gervais A, et al
    Neutralizing IFN-gamma autoantibodies are rare and pathogenic in HLA-DRB1*15:02 or 16:02 individuals.
    J Clin Invest. 2024;134:e178263.
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