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Eur J Pharmacol
    July 2021
  1. HUANG N, Zhu TT, Liu T, Ge XY, et al
    Aspirin ameliorates pulmonary vascular remodeling in pulmonary hypertension by dampening endothelial-to-mesenchymal transition.
    Eur J Pharmacol. 2021;908:174307.
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  2. BATISTA RIM, Nogueira RC, Ferreira GC, Oliveira-Paula GH, et al
    Antiseptic mouthwash inhibits antihypertensive and vascular protective effects of L-arginine.
    Eur J Pharmacol. 2021;907:174314.
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  3. LV Y, Ma P, Wang J, Xu Q, et al
    Betaine alleviates right ventricular failure via regulation of Rho A/ROCK signaling pathway in rats with pulmonary arterial hypertension.
    Eur J Pharmacol. 2021 Jul 7:174311. doi: 10.1016/j.ejphar.2021.174311.
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    June 2021
  4. ZHU JX, Ling W, Xue C, Zhou Z, et al
    Higenamine attenuates cardiac fibroblast abstract and fibrosis via inhibition of TGF-beta1/Smad signaling.
    Eur J Pharmacol. 2021;900:174013.
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    May 2021
  5. BUNBUPHA S, Prasarttong P, Poasakate A, Maneesai P, et al
    Imperatorin alleviates metabolic and vascular alterations in high-fat/high-fructose diet-fed rats by modulating adiponectin receptor 1, eNOS, and p47(phox) expression.
    Eur J Pharmacol. 2021;899:174010.
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  6. DOGHRI Y, Dubreil L, Lalanne V, Helissen O, et al
    Soluble guanylate cyclase chronic stimulation effects on cardiovascular reactivity in cafeteria diet-induced rat model of metabolic syndrome.
    Eur J Pharmacol. 2021;899:173978.
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    April 2021
  7. SILVA EAP, Carvalho JS, Dos Santos DM, Oliveira AMS, et al
    Cardiovascular effects of farnesol and its beta-cyclodextrin complex in normotensive and hypertensive rats.
    Eur J Pharmacol. 2021 Apr 2:174060. doi: 10.1016/j.ejphar.2021.174060.
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    March 2021
  8. SHI Y, Jiang R, Qin X, Gao A, et al
    Up-regulation of nPKC contributes to proliferation of mice pulmonary artery smooth muscle cells in hypoxia-induced pulmonary hypertension.
    Eur J Pharmacol. 2021 Mar 18:174046. doi: 10.1016/j.ejphar.2021.174046.
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  9. POORGOLIZADEH E, Homayouni Moghadam F, Dormiani K, Rezaei N, et al
    Do neprilysin inhibitors walk the line? Heart ameliorative but brain threatening!
    Eur J Pharmacol. 2021;894:173851.
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    February 2021
  10. JASINSKA-STROSCHEIN M, Orszulak-Michalak D
    Reporting experimental studies on animals - The problems with translating of outcomes to clinical benefits. Methodological and statistical considerations: The example of pulmonary hypertension.
    Eur J Pharmacol. 2021;897:173952.
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  11. GONZAGA-COSTA K, Vasconcelos-Silva AA, Rodrigues-Silva MJ, Rebouca CDSM, et al
    Soluble guanylate cyclase stimulator, trans-4-methoxy-beta-nitrostyrene, has a beneficial effect in monocrotaline-induced pulmonary arterial hypertension in rats.
    Eur J Pharmacol. 2021;897:173948.
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  12. ZHANG Y, Luo W, Li H, Yu G, et al
    Larger endothelium-dependent contractions in iliac arteries of adult SHRs are attributed to differential downregulation of TP and EP3 receptors in the vessels of WKYs and SHRs during the transition from adolescence to adulthood.
    Eur J Pharmacol. 2021;893:173828.
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    November 2020
  13. LIU T, Hong L, Yang Y, Qiao X, et al
    Metformin reduces proteinuria in spontaneously hypertensive rats by activating the HIF-2alpha-VEGF-A pathway.
    Eur J Pharmacol. 2020 Nov 18:173731. doi: 10.1016/j.ejphar.2020.173731.
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  14. ZIMMER A, Teixeira RB, Constantin RL, Campos-Carraro C, et al
    The progression of pulmonary arterial hypertension induced by monocrotaline is characterized by lung nitrosative and oxidative stress, and impaired pulmonary artery reactivity.
    Eur J Pharmacol. 2020 Nov 5:173699. doi: 10.1016/j.ejphar.2020.173699.
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  15. ESCUDERO DS, Brea MS, Caldiz CI, Amarillo ME, et al
    PDE5 inhibition improves cardiac morphology and function in SHR by reducing NHE1 activity: Repurposing sildenafil for the treatment of hypertensive cardiac hypertrophy.
    Eur J Pharmacol. 2020 Nov 2:173724. doi: 10.1016/j.ejphar.2020.173724.
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    October 2020
  16. MULVANEY EP, Reid HM, Bialesova L, Mendes-Ferreira P, et al
    Efficacy of the thromboxane receptor antagonist NTP42 alone, or in combination with sildenafil, in the sugen/hypoxia-induced model of pulmonary arterial hypertension.
    Eur J Pharmacol. 2020 Oct 26:173658. doi: 10.1016/j.ejphar.2020.173658.
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    September 2020
  17. GUIL MJ, Soria C, Seijas M, Bianciotti LG, et al
    Central endothelin ETB receptor activation reduces blood pressure and catecholaminergic activity in the olfactory bulb of deoxycorticosterone acetate-salt hypertensive rats.
    Eur J Pharmacol. 2020 Sep 4:173543. doi: 10.1016/j.ejphar.2020.173543.
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    August 2020
  18. CHEN Y, Yuan T, Chen D, Liu S, et al
    Systematic analysis of molecular mechanism of resveratrol for treating pulmonary hypertension based on network pharmacology technology.
    Eur J Pharmacol. 2020 Aug 13:173466. doi: 10.1016/j.ejphar.2020.173466.
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  19. FONSECA DA SILVA RCMVA, Boeing T, Bolda Mariano LN, Somensi LB, et al
    The pathophysiology of acute gastric ulcer development in normotensive and hypertensive rats: A comparative study.
    Eur J Pharmacol. 2020 Aug 12:173469. doi: 10.1016/j.ejphar.2020.173469.
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  20. BRAGA CL, Felix NS, Teixeira DE, Vieira JB, et al
    Niclosamide attenuates lung vascular remodeling in experimental pulmonary arterial hypertension.
    Eur J Pharmacol. 2020 Aug 11:173438. doi: 10.1016/j.ejphar.2020.173438.
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  21. HEGAZY M, El-Shafey M, Abulsoud AI, Elsadek BEM, et al
    Pioglitazone ameliorates high fat diet-induced hypertension and induces catechol o-methyl transferase expression in rats.
    Eur J Pharmacol. 2020 Aug 1:173383. doi: 10.1016/j.ejphar.2020.173383.
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    June 2020
  22. RODRIGUEZ JE, Ruiz-Hernandez A, Hernandez-DiazCouder A, Huang F, et al
    Chronic diabetes and hypertension impair the in vivo functional response to phenylephrine independent of alpha1-adrenoceptor expression.
    Eur J Pharmacol. 2020;883:173283.
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  23. SHIMIZU S, Nagao Y, Kataoka T, Kamada S, et al
    Protective effects of tadalafil on prostatic hyperplasia in spontaneously hypertensive rats.
    Eur J Pharmacol. 2020 Jun 27:173313. doi: 10.1016/j.ejphar.2020.173313.
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  24. DJOKIC V, Jankovic S, Labudovic-Borovic M, Rakocevic J, et al
    Pregnancy-induced hypertension decreases Kv1.3 potassium channel expression and function in human umbilical vein smooth muscle.
    Eur J Pharmacol. 2020 Jun 17:173281. doi: 10.1016/j.ejphar.2020.173281.
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  25. AZHAR AS, Zaher ZF, Ashour OM, Abdel-Naim AB, et al
    2-Methoxyestradiol ameliorates metabolic syndrome-induced hypertension and catechol-O-methyltransferase inhibited expression and activity in rats.
    Eur J Pharmacol. 2020 Jun 13:173278. doi: 10.1016/j.ejphar.2020.173278.
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  26. LIU Y, Shen W, Chen Q, Cao Q, et al
    Inhibition of RAGE by FPS-ZM1 alleviates renal injury in spontaneously hypertensive rats.
    Eur J Pharmacol. 2020 Jun 2:173228. doi: 10.1016/j.ejphar.2020.173228.
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    May 2020
  27. OYAGBEMI AA, Omobowaleb TO, Adejumobi OA, Owolabi AM, et al
    Antihypertensive power of Naringenin is mediated via attenuation of mineralocorticoid receptor (MCR)/ angiotensin converting enzyme (ACE)/ kidney injury molecule (Kim-1) signaling pathway.
    Eur J Pharmacol. 2020 May 15:173142. doi: 10.1016/j.ejphar.2020.173142.
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    November 2019
  28. ABOUELKHEIR M, El-Metwally TH
    Dipeptidyl peptidase-4 inhibitors can inhibit angiotensin converting enzyme.
    Eur J Pharmacol. 2019;862:172638.
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  29. NOVELLI D, Fumagalli F, Staszewsky L, Ristagno G, et al
    Monocrotaline-induced pulmonary arterial hypertension: Time-course of injury and comparative evaluation of macitentan and Y-27632, a Rho kinase inhibitor.
    Eur J Pharmacol. 2019 Nov 4:172777. doi: 10.1016/j.ejphar.2019.172777.
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    October 2019
  30. ZHU C, Tian L, Yang H, Chen P, et al
    Mitochondrial outer membrane voltage-dependent anion channel is involved in renal dysfunction in a spontaneously hypertensive rat carrying transfer RNA mutations.
    Eur J Pharmacol. 2019 Oct 13:172622. doi: 10.1016/j.ejphar.2019.172622.
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    September 2019
  31. LIU H, Ge XY, Huang N, Liu T, et al
    Up-regulation of cullin7 promotes proliferation and migration of pulmonary artery smooth muscle cells in hypoxia-induced pulmonary hypertension.
    Eur J Pharmacol. 2019 Sep 26:172698. doi: 10.1016/j.ejphar.2019.172698.
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  32. LIU T, Zou XZ, Huang N, Ge XY, et al
    Down-regulation of miR-204 attenuates endothelial-mesenchymal transition by enhancing autophagy in hypoxia-induced pulmonary hypertension.
    Eur J Pharmacol. 2019 Sep 19:172673. doi: 10.1016/j.ejphar.2019.172673.
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  33. ZHANG X, Mao A, Xiao W, Zhang P, et al
    Morin induces endothelium-dependent relaxation by activating TRPV4 channels in rat mesenteric arteries.
    Eur J Pharmacol. 2019;859:172561.
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    June 2019
  34. SINGH A, Kumar BS, Iqbal H, Alam S, et al
    Antihypertensive activity of diethyl-4,4'-dihydroxy-8,3'-neolign-7,7'-dien-9,9'-dionate: A continuation study in L-NAME treated wistar rats.
    Eur J Pharmacol. 2019;858:172482.
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  35. WANG EL, Jia MM, Luo FM, Li T, et al
    Coordination between NADPH oxidase and vascular peroxidase 1 promotes dysfunctions of endothelial progenitor cells in hypoxia-induced pulmonary hypertensive rats.
    Eur J Pharmacol. 2019 Jun 16:172459. doi: 10.1016/j.ejphar.2019.172459.
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    May 2019
  36. XING XQ, Li B, Xu SL, Zhang CF, et al
    5-Aza-2'-deoxycytidine, a DNA methylation inhibitor, attenuates hypoxic pulmonary hypertension via demethylation of the PTEN promoter.
    Eur J Pharmacol. 2019 May 11. pii: S0014-2999(19)30325.
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  37. ZHOU Y, Liu X, Zhang X, Wen J, et al
    Decreased vasodilatory effect of Tanshinone A Sodium Sulfonate on mesenteric artery in hypertension.
    Eur J Pharmacol. 2019;854:365-371.
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    April 2019
  38. MAZUR I, Belenichev I, Kucherenko L, Bukhtiyarova N, et al
    Antihypertensive and cardioprotective effects of new compound 1-(beta-phenylethyl)-4-amino-1,2,4-triazolium bromide (Hypertril).
    Eur J Pharmacol. 2019 Apr 9. pii: S0014-2999(19)30241.
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    February 2019
  39. SEN Z, Weida W, Li Y, Zhaojun L, et al
    Nicousamide attenuates renal dysfunction and glomerular injury in remnant kidneys by inhibiting TGF-beta1 internalisation and renin activity.
    Eur J Pharmacol. 2019;845:74-84.
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  40. CANTONI S, Cavalli S, Pastore F, Accetta A, et al
    Pharmacological characterization of a highly selective Rho-kinase (ROCK) inhibitor and its therapeutic effects in experimental pulmonary hypertension.
    Eur J Pharmacol. 2019 Feb 9. pii: S0014-2999(19)30102.
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  41. YU X, Zhao X, Zhang J, Li Y, et al
    Dacomitinib, a new pan-EGFR inhibitor, is effective in attenuating pulmonary vascular remodeling and pulmonary hypertension.
    Eur J Pharmacol. 2019 Feb 9. pii: S0014-2999(19)30095.
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  42. KAMADA R, Yokoshiki H, Mitsuyama H, Watanabe M, et al
    Arrhythmogenic beta-adrenergic signaling in cardiac hypertrophy: The role of small-conductance calcium-activated potassium channels via activation of CaMKII.
    Eur J Pharmacol. 2019;844:110-117.
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  43. MARCUS AJ, Iezhitsa I, Agarwal R, Vassiliev P, et al
    Intraocular pressure-lowering effects of imidazo[1,2-a]- and pyrimido[1,2-a]benzimidazole compounds in rats with dexamethasone-induced ocular hypertension.
    Eur J Pharmacol. 2019 Feb 1. pii: S0014-2999(19)30082.
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    January 2019
  44. LI T, Luo XJ, Wang EL, Li NS, et al
    Magnesium lithospermate B prevents phenotypic transformation of pulmonary arteries in rats with hypoxic pulmonary hypertension through suppression of NADPH oxidase.
    Eur J Pharmacol. 2019 Jan 16. pii: S0014-2999(19)30028.
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    November 2018
  45. DAI G, Li B, Xu Y, Zeng Z, et al
    Oxymatrine prevents the development of monocrotaline-induced pulmonary hypertension via regulation of the N(G), N(G)-dimethyl-L-arginine metabolism pathways in rats.
    Eur J Pharmacol. 2018 Nov 9. pii: S0014-2999(18)30656.
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    October 2018
  46. HONG XY, Hong X, Gu WW, Lin J, et al
    Cardioprotection and improvement in endothelial-dependent vasodilation during late-phase of whole body hypoxic preconditioning in spontaneously hypertensive rats via VEGF and endothelin-1.
    Eur J Pharmacol. 2018;842:79-88.
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  47. IGREJA B, Pires NM, Wright LC, Soares-da-Silva P, et al
    Effects of zamicastat treatment in a genetic model of salt-sensitive hypertension and heart failure.
    Eur J Pharmacol. 2018;842:125-132.
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  48. YADAV VR, Teng B, Mustafa SJ
    Enhanced A1 adenosine receptor-induced vascular contractions in mesenteric artery and aorta of in L-NAME mouse model of hypertension.
    Eur J Pharmacol. 2018 Oct 19. pii: S0014-2999(18)30607.
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  49. NASCIMENTO RA, Possomato-Vieira JS, Goncalves-Rizzi VH, Bonacio GF, et al
    Hypertension, augmented activity of matrix metalloproteinases-2 and -9 and angiogenic imbalance in hypertensive pregnancy are attenuated by doxycycline.
    Eur J Pharmacol. 2018;840:60-69.
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  50. SU J, Huang M
    Etidronate protects chronic ocular hypertension induced retinal oxidative stress and promotes retinal ganglion cells growth through IGF-1 signaling pathway.
    Eur J Pharmacol. 2018 Oct 13. pii: S0014-2999(18)30577.
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    July 2018
  51. MORRIS R, Spencer SK, Barnes A, Bowles T, et al
    Attenuation of oxidative stress and hypertension in an animal model of HELLP syndrome.
    Eur J Pharmacol. 2018 Jul 13. pii: S0014-2999(18)30380.
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  52. TAHARA A, Takasu T
    Prevention of progression of diabetic nephropathy by the SGLT2 inhibitor ipragliflozin in uninephrectomized type 2 diabetic mice.
    Eur J Pharmacol. 2018;830:68-75.
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  53. CARVALHO DS, de Almeida AA, Borges AF, Vannucci Campos D, et al
    Treatments for diabetes mellitus type II: New perspectives regarding the possible role of calcium and cAMP interaction.
    Eur J Pharmacol. 2018;830:9-16.
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    June 2018
  54. ZHANG C, Booz GW, Yu Q, He X, et al
    Conflicting roles of 20-HETE in hypertension and renal end organ damage.
    Eur J Pharmacol. 2018 Jun 7. pii: S0014-2999(18)30342.
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    May 2018
  55. ZHOU Y, Tian X, Wang X, Wang Y, et al
    Quaternary ammonium salt of U50,488H elicits protective effects against hypoxic pulmonary hypertension.
    Eur J Pharmacol. 2018 May 18. pii: S0014-2999(18)30288.
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    April 2018
  56. LAN TH, Chen XL, Wu YS, Qiu HL, et al
    3,7-Bis(2-hydroxyethyl)icaritin, a potent inhibitor of phosphodiesterase-5, prevents monocrotaline-induced pulmonary arterial hypertension via NO/cGMP activation in rats.
    Eur J Pharmacol. 2018 Apr 14. pii: S0014-2999(18)30222.
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    February 2018
  57. BHAT L, Hawkinson J, Cantillon M, Reddy DG, et al
    Evaluation of the effects of RP5063, a novel, multimodal, serotonin receptor modulator, as single-agent therapy and co-administrated with sildenafil, bosentan, and treprostinil in a monocrotaline-induced pulmonary arterial hypertension rat model.
    Eur J Pharmacol. 2018 Feb 14. pii: S0014-2999(18)30096.
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    January 2018
  58. GONCALVES-RIZZI VH, Possomato-Vieira JS, Nascimento RA, Caldeira-Dias M, et al
    Maternal hypertension and feto-placental growth restriction is reversed by sildenafil: Evidence of independent effects of circulating nitric oxide levels.
    Eur J Pharmacol. 2018 Jan 17. pii: S0014-2999(18)30017.
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  59. MARTINS-OLIVEIRA A, Guimaraes DA, Ceron CS, Rizzi E, et al
    Direct renin inhibition is not enough to prevent reactive oxygen species generation and vascular dysfunction in renovascular hypertension.
    Eur J Pharmacol. 2018;821:97-104.
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  60. BELADIYA JV, Chaudagar KK, Mehta AA
    A protective role of Galphaq-RGS2 loop activator on streptozotocin induced diabetic complications in rats: An independent on elevated serum glucose level modulation.
    Eur J Pharmacol. 2018;818:141-147.
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    December 2017
  61. ZHANG N, Dong M, Luo Y, Zhao F, et al
    Danshensu prevents hypoxic pulmonary hypertension in rats by inhibiting the proliferation of pulmonary artery smooth muscle cells via TGF-beta-smad3-associated pathway.
    Eur J Pharmacol. 2017 Dec 5. pii: S0014-2999(17)30794.
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  62. LEBLANC C, Tabrizchi R
    Role of beta2- and beta3-adrenoceptors in arterial stiffness in a state of hypertension.
    Eur J Pharmacol. 2017 Dec 2. pii: S0014-2999(17)30783.
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    November 2017
  63. WU Y, Qian Z, Fu S, Yue Y, et al
    IcarisideII improves left ventricular remodeling in spontaneously hypertensive rats by inhibiting the ASK1-JNK/p38 signaling pathway.
    Eur J Pharmacol. 2017 Nov 21. pii: S0014-2999(17)30768.
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    October 2017
  64. ZHANG W, Zhu T, Wu W, Ge X, et al
    LOX-1 mediated phenotypic switching of pulmonary arterial smooth muscle cells contributes to hypoxic pulmonary hypertension.
    Eur J Pharmacol. 2017;818:84-95.
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    September 2017
  65. SUN P, Sun H, Zhang W, Du Z, et al
    Antagonist of thromboxane A2 receptor by SQ29548 lowers DOCA-induced hypertension in diabetic rats.
    Eur J Pharmacol. 2017 Sep 20. pii: S0014-2999(17)30614.
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    August 2017
  66. SILVA BR, Pernomian L, De Paula TD, Grando MD, et al
    Endothelial nitric oxide synthase and cyclooxygenase are activated by hydrogen peroxide in renal hypertensive rat aorta.
    Eur J Pharmacol. 2017 Aug 2. pii: S0014-2999(17)30503.
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    July 2017
  67. SINGH A, Kumar BS, Alam S, Iqbal H, et al
    Corrigendum to "Diethyl-4,4'-dihydroxy-8,3'-neolign-7,7'-dien-9,9'-dionate exhibits antihypertensive activity in rats through increase in intracellular cGMP level and blockade of calcium channels" [Eur. J. Pharmacol. 799 (2017) 84-93].
    Eur J Pharmacol. 2017;806:111.
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  68. JIANG D, Kawagoe Y, Kuwasako K, Kitamura K, et al
    Inhibitory effects of losartan and azelnidipine on augmentation of blood pressure variability induced by angiotensin II in rats.
    Eur J Pharmacol. 2017;806:91-95.
    >> Share

    June 2017
  69. YAMAMURA A, Fujitomi E, Ohara N, Tsukamoto K, et al
    Tadalafil induces antiproliferation, apoptosis, and phosphodiesterase type 5 downregulation in idiopathic pulmonary arterial hypertension in vitro.
    Eur J Pharmacol. 2017 Jun 8. pii: S0014-2999(17)30400.
    >> Share

    May 2017
  70. BHAT L, Hawkinson J, Cantillon M, Reddy DG, et al
    RP5063, a novel, multimodal, serotonin receptor modulator, prevents monocrotaline-induced pulmonary arterial hypertension in rats.
    Eur J Pharmacol. 2017 May 31. pii: S0014-2999(17)30380.
    >> Share

  71. BHAT L, Hawkinson J, Cantillon M, Reddy DG, et al
    RP5063, a novel, multimodal, serotonin receptor modulator, prevents Sugen 5416-hypoxia-induced pulmonary arterial hypertension in rats.
    Eur J Pharmacol. 2017 May 30. pii: S0014-2999(17)30381.
    >> Share

  72. SAVIGNANO FA, Crajoinas RO, Pacheco BPM, Campos LCG, et al
    Attenuated diuresis and natriuresis in response to glucagon-like peptide-1 in hypertensive rats are associated with lower expression of the glucagon-like peptide-1 receptor in the renal vasculature.
    Eur J Pharmacol. 2017 May 30. pii: S0014-2999(17)30386.
    >> Share

    March 2017
  73. BOMFIM GH, Mendez-Lopez I, Fernandez-Morales JC, Padin JF, et al
    Electrophysiological properties and augmented catecholamine release from chromaffin cells of WKY and SHR rats contributing to the hypertension development elicited by chronic EtOH consumption.
    Eur J Pharmacol. 2017 Mar 16. pii: S0014-2999(17)30179.
    >> Share

    February 2017
  74. YOON JJ, Lee YJ, Han BH, Choi ES, et al
    Protective effect of betulinic acid on early atherosclerosis in diabetic apolipoprotein-E gene knockout mice.
    Eur J Pharmacol. 2017;796:224-232.
    >> Share

    January 2017
  75. AL SULEIMANI YM, Al Mahruqi AS
    The endogenous lipid N-arachidonoyl glycine is hypotensive and nitric oxide-cGMP-dependent vasorelaxant.
    Eur J Pharmacol. 2017;794:209-215.
    >> Share

    December 2016
  76. MOSTAFA DK, Nasra RA, Zahran N, Ghoneim MT, et al
    Pleiotropic protective effects of Vitamin D against high fat diet-induced metabolic syndrome in rats: One for all.
    Eur J Pharmacol. 2016;792:38-47.
    >> Share

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