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Articles published in
Eur J Pharmacol
    September 2025
  1. QIN Y, Sha Z, Qiao Y, Yan G, et al
    Phospholysine phosphohistidine inorganic pyrophosphate phosphatase Suppresses Glycolysis and Proliferation of Pulmonary Artery Smooth Muscle Cells in Hypoxic Pulmonary Hypertension via Inhibition of lactate dehydrogenase A.
    Eur J Pharmacol. 2025 Sep 20:178172. doi: 10.1016/j.ejphar.2025.178172.
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  2. YU X, Li Q, Zhang D, Guo K, et al
    KN060-a humanized dual-domain antibody simultaneously targeting FXI-A2/A3 epitopes: Pioneering the anti-coagulation factor XI strategy for Aterial hypertension - Evidence from preclinical models.
    Eur J Pharmacol. 2025;1006:178171.
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  3. CHANDHRU M, Ramamurthy K, Sudhakaran G, Choi KC, et al
    Aging-related epigenetic instability in lncRNAs and miRNAs mediates the development of hypertension.
    Eur J Pharmacol. 2025 Sep 12:178150. doi: 10.1016/j.ejphar.2025.178150.
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    July 2025
  4. LU GQ, Sun HY, Xu MY, Sun ZY, et al
    Salidroside ameliorates monocrotaline-induced pulmonary arterial hypertension in rats by modulating BKCa channels.
    Eur J Pharmacol. 2025;1004:177950.
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  5. LI Y, Zhang Y, Chen Y, Qiao Z, et al
    SIRT3 mediates Tubeimoside I's inhibition on pulmonary artery smooth muscle cell proliferation and oxidative stress in pulmonary arterial hypertension.
    Eur J Pharmacol. 2025 Jul 18:177938. doi: 10.1016/j.ejphar.2025.177938.
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  6. LI WH, Ma WJ, Zhang W, Zhao SN, et al
    Programmed Cell Death: A Pivotal Player in Pulmonary Arterial Hypertension.
    Eur J Pharmacol. 2025 Jul 8:177934. doi: 10.1016/j.ejphar.2025.177934.
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  7. MA WJ, Li WH, Zhao XM, Zhang W, et al
    Significance of ALDH3A2, a mitochondrial metabolism and glycolysis related gene, in pulmonary arterial hypertension.
    Eur J Pharmacol. 2025;1003:177923.
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  8. HOU B, Su S, Ji L, Huayu M, et al
    Luteolin alleviates right ventricular hypertrophy in high altitude pulmonary hypertension rats by regulating PI3K/AKT/mTOR signalling pathway.
    Eur J Pharmacol. 2025 Jul 1:177898. doi: 10.1016/j.ejphar.2025.177898.
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  9. GAO C, Li J, Feng F, Fu J, et al
    EDIL3 regulates pulmonary artery smooth muscle cell proliferation and migration via integrin alphaVbeta3/ERK1/2 axis in pulmonary hypertension.
    Eur J Pharmacol. 2025 Jul 1:177901. doi: 10.1016/j.ejphar.2025.177901.
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    May 2025
  10. LUO M, Du Y, Liu X, Zhang S, et al
    Fecal Microbiota Transplantation Alleviates Cirrhotic Portal Hypertension in Rats via Butyrate-Mediated HDAC3 Inhibition and PI3K/Akt/eNOS Signaling Regulation.
    Eur J Pharmacol. 2025 May 27:177781. doi: 10.1016/j.ejphar.2025.177781.
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  11. WU M, Zhou Y, Guo Z, Lian D, et al
    Isoliensinine promotes vasorelaxation and inhibits constriction by regulating the calcium channel in hypertension: In vitro and in vivo approaches.
    Eur J Pharmacol. 2025 May 23:177765. doi: 10.1016/j.ejphar.2025.177765.
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  12. WANG Y, Zhang Y, An X, Jiang Y, et al
    New LFA-1 inhibitor Orientin reduces angiotensin II-induced vascular remodeling.
    Eur J Pharmacol. 2025;995:177426.
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  13. MINARI TP, Pisani LP
    Exploring Sodium Nitrate Supplementation in Enhancing Nitric Oxide Bioavailability and Reducing Oxidative Stress: Implications for Blood Pressure and Endothelial Dysfunction in Hypertension.
    Eur J Pharmacol. 2025 May 3:177702. doi: 10.1016/j.ejphar.2025.177702.
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    April 2025
  14. WANG H, Peng LJ, Lu W, Li GR, et al
    Acacetin reverses hypoxic pulmonary hypertension by inhibiting hypoxia-induced proliferation of pulmonary artery smooth muscle cells via SIRT1-HMGB1 pathway.
    Eur J Pharmacol. 2025 Apr 19:177650. doi: 10.1016/j.ejphar.2025.177650.
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    March 2025
  15. BISWAS AM, Emran T, Khan SI, Shabnam S, et al
    Transforming Growth Factor-beta-mediated attenuation of cardio-renal oxidative stress, inflammation and fibrosis by L-arginine in fludrocortisone acetate induced-hypertensive rats.
    Eur J Pharmacol. 2025 Mar 26:177559. doi: 10.1016/j.ejphar.2025.177559.
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  16. CARVALHO KFS, de Lima JF, Silva JLM, de Almeida CR, et al
    Toll-like receptor 9 contributes to perivascular adipose tissue dysfunction in spontaneously hypertensive rats.
    Eur J Pharmacol. 2025;998:177524.
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    February 2025
  17. HAMDY A, El-Bassossy HM, Elshazly SM, El-Sayed SS, et al
    Statins boost beneficial pleiotropic cardiovascular effects of cilostazol in angiotensin-II hypertensive rats.
    Eur J Pharmacol. 2025 Feb 27:177442. doi: 10.1016/j.ejphar.2025.177442.
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  18. SHANAHATI D, Yang T, Fang L, Nijiati Y, et al
    18beta-Glycyrrhetinic acid improves pulmonary hypertension by regulating the vascukar non-inflammatory molecule-1/L-arginine/nitric oxide signaling pathway.
    Eur J Pharmacol. 2025 Feb 21:177382. doi: 10.1016/j.ejphar.2025.177382.
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  19. GUO Z, Wu M, Chen L, Chen H, et al
    Neferine attenuates hypertensive cardiomyocyte apoptosis and modulates key signaling pathways: An in vivo and in vitro study.
    Eur J Pharmacol. 2025;994:177393.
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  20. BAI J, Gao D, Mei J, Yuan H, et al
    Exonic CircGUCY1A2 Inhibits Pulmonary Artery Smooth Muscle Cells Phenotypic Switching Via Regulating O-glycosylation of COL3A1 in Pulmonary Hypertension.
    Eur J Pharmacol. 2025 Feb 4:177328. doi: 10.1016/j.ejphar.2025.177328.
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    January 2025
  21. JOVANOVIC A
    Editorial: Research and development of new treatments for hypertension.
    Eur J Pharmacol. 2025 Jan 31:177321. doi: 10.1016/j.ejphar.2025.177321.
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  22. JOVANOVIC A
    Editorial: Research and development of new treatments for hypertension.
    Eur J Pharmacol. 2025 Jan 28:177318. doi: 10.1016/j.ejphar.2025.177318.
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    December 2024
  23. SHARMA A, Kapur S, Kancharla P, Yang T, et al
    Sex differences in gut microbiota, hypertension, and cardiovascular risk.
    Eur J Pharmacol. 2024;987:177183.
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  24. GAWRYS O, Kala P, Sadowski J, Melenovsky V, et al
    Soluble guanylyl cyclase stimulators and activators: Promising drugs for the treatment of hypertension?
    Eur J Pharmacol. 2024;987:177175.
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    November 2024
  25. LU G, Du R, Lu L, Wang Q, et al
    Macrophage-specific kappa-OR knockout exacerbates inflammation in hypoxic pulmonary hypertension.
    Eur J Pharmacol. 2024 Nov 23:177152. doi: 10.1016/j.ejphar.2024.177152.
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  26. PARVAN R, Aboumsallem JP, Meijers WC, De Boer RA, et al
    Innovative hypertension treatments: Transitioning from conventional therapies to siRNA-based solutions.
    Eur J Pharmacol. 2024;985:177110.
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  27. ZHANG F, Guo Z, Wu M, Lin G, et al
    Trifolin Attenuates Hypertension-Mediated Cardiac Injury by Inhibiting Cardiomyocyte Apoptosis: Mechanistic Insights and Therapeutic Potential.
    Eur J Pharmacol. 2024 Nov 9:177125. doi: 10.1016/j.ejphar.2024.177125.
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  28. BROSOLO G, Da Porto A, Marcante S, Capilupi F, et al
    The role for omega-3 polyunsaturated and short chain fatty acids in hypertension: An updated view on the interaction with gut microbiota.
    Eur J Pharmacol. 2024;985:177107.
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  29. LIU A, Wang Y, Zheng S, Bao Z, et al
    Endonuclear Circ-calm4 regulates ferroptosis via a circR-Loop of the COMP gene in pulmonary artery smooth muscle cells.
    Eur J Pharmacol. 2024;982:176944.
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    October 2024
  30. LIU DD, Liu XL, Zheng TF, Li X, et al
    Dapagliflozin alleviates right heart failure by promoting collagen degradation by reducing ROS levels.
    Eur J Pharmacol. 2024;981:176875.
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  31. WINNER G J, Jain S, Gupta D
    Unveiling Novel Molecules and Therapeutic Targets in Hypertension - A Narrative Review.
    Eur J Pharmacol. 2024 Oct 9:177053. doi: 10.1016/j.ejphar.2024.177053.
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  32. WANG H, Gao Y, Bai J, Liu H, et al
    CircLMBR1 inhibits phenotypic transformation of hypoxia-induced pulmonary artery smooth muscle via the splicing factor PUF60.
    Eur J Pharmacol. 2024;980:176855.
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    September 2024
  33. R MURALITHARAN R, Marques FZ, O'Donnell JA
    Recent advancements in targeting the immune system to treat hypertension.
    Eur J Pharmacol. 2024 Sep 18:177008. doi: 10.1016/j.ejphar.2024.177008.
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  34. CASTIGLIONI L, Gelosa P, Muluhie M, Mercuriali B, et al
    Fenofibrate reduces cardiac remodeling by mitochondrial dynamics preservation in a renovascular model of cardiac hypertrophy.
    Eur J Pharmacol. 2024;978:176767.
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  35. BLASCKE DE MELLO MM, Neves VGO, Parente JM, Pernomian L, et al
    Sarcoplasmic reticulum calcium ATPase (SERCA) proteolysis by matrix metalloproteinase-2 contributes to vascular dysfunction in early hypertension.
    Eur J Pharmacol. 2024;983:176981.
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    July 2024
  36. WANG Y, Han D, Chai L, Qiu Y, et al
    MFN2-dependent mitochondrial dysfunction contributes to Relm-beta-induced pulmonary arterial hypertension via USP18/Twist1/miR-214 pathway.
    Eur J Pharmacol. 2024 Jul 31:176828. doi: 10.1016/j.ejphar.2024.176828.
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  37. ZHAO Z, Fan Q, Zhang C, Zheng L, et al
    Imperatorin attenuates CCl(4)-induced cirrhosis and portal hypertension by improving vascular remodeling and profibrogenic pathways.
    Eur J Pharmacol. 2024 Jul 30:176833. doi: 10.1016/j.ejphar.2024.176833.
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  38. BLAZEK O, Bakris GL
    A review of Novel Endothelin antagonists and overview of non-steroidal mineralocorticoid antagonists for treating resistant hypertension: An Update.
    Eur J Pharmacol. 2024 Jul 22:176752. doi: 10.1016/j.ejphar.2024.176752.
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    June 2024
  39. WANG X, Cui L, Wang Y, Zeng Z, et al
    Mechanistic investigation of wogonin in delaying the progression of endothelial mesenchymal transition by targeting the TGF-beta1 pathway in pulmonary hypertension.
    Eur J Pharmacol. 2024;978:176786.
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  40. DAI X, Liu Y, Wu Y, Wang S, et al
    DYZY01 alleviates pulmonary hypertension via inhibiting endothelial cell pyroptosis and rescuing endothelial dysfunction.
    Eur J Pharmacol. 2024;978:176785.
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    May 2024
  41. SHELKE V, Dagar N, Puri B, Gaikwad AB, et al
    Natriuretic peptide system in hypertension: Current understandings of its regulation, targeted therapies and future challenges.
    Eur J Pharmacol. 2024;976:176664.
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    April 2024
  42. YAMAMURA A, Fujiwara M, Kawade A, Amano T, et al
    Corosolic acid attenuates platelet-derived growth factor signaling in macrophages and smooth muscle cells of pulmonary arterial hypertension.
    Eur J Pharmacol. 2024;973:176564.
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  43. LAXMI, Golmei P, Srivastava S, Kumar S, et al
    Single nucleotide polymorphism-based biomarker in primary hypertension.
    Eur J Pharmacol. 2024;972:176584.
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  44. LI Q, Cao H, Xu X, Chen Y, et al
    Resveratrol attenuates cyclosporin A-induced upregulation of the thromboxane A(2) receptor and hypertension via the AMPK/SIRT1 and MAPK/NF-kappaB pathways in the rat mesenteric artery.
    Eur J Pharmacol. 2024;972:176543.
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    March 2024
  45. BENCZE M, Boros A, Behuliak M, Vavrinova A, et al
    Changes in cardiovascular autonomic control induced by chronic inhibition of acetylcholinesterase during pyridostigmine or donepezil treatment of spontaneously hypertensive rats.
    Eur J Pharmacol. 2024 Mar 25:176526. doi: 10.1016/j.ejphar.2024.176526.
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  46. WANG J, Liu C, Huang SS, Wang HF, et al
    Functions and novel regulatory mechanisms of key glycolytic enzymes in pulmonary arterial hypertension.
    Eur J Pharmacol. 2024;970:176492.
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  47. CHEN Y, Liu J, Zhang Q, Chai L, et al
    Activation of CaMKII/HDAC4 by SDF1 contributes to pulmonary arterial hypertension via stabilization Runx2.
    Eur J Pharmacol. 2024;970:176483.
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  48. TANNA S, Doshi G, Godad A
    siRNA as potential therapeutic strategy for hypertension.
    Eur J Pharmacol. 2024;969:176467.
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    February 2024
  49. FU LY, Yang Y, Tian H, Jia XY, et al
    Central administration of AICAR attenuates hypertension via AMPK/Nrf2 pathway in the hypothalamic paraventricular nucleus of hypertensive rats.
    Eur J Pharmacol. 2024 Feb 8:176373. doi: 10.1016/j.ejphar.2024.176373.
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    January 2024
  50. LIU Q, Luo Q, Zhong B, Tang K, et al
    Salidroside attenuates myocardial remodeling in DOCA-salt-induced mice by inhibiting the endothelin 1 and PI3K/AKT/NFkappaB signaling pathways.
    Eur J Pharmacol. 2024;962:176236.
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  51. LI MH, Liu X, Xie YL, Tang XG, et al
    Sodium butyrate alleviates right ventricular hypertrophy in pulmonary arterial hypertension by inhibiting H19 and affecting the activation of let-7g-5p/IGF1 receptor/ERK.
    Eur J Pharmacol. 2024 Jan 2:176315. doi: 10.1016/j.ejphar.2024.176315.
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    December 2023
  52. FAN Q, Wu G, Chen M, Luo G, et al
    Cediranib ameliorates portal hypertensive syndrome via inhibition of VEGFR-2 signaling in cirrhotic rats.
    Eur J Pharmacol. 2023 Dec 27:176278. doi: 10.1016/j.ejphar.2023.176278.
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  53. QAYYUM MI, Ullah S, Rashid U, Sadiq A, et al
    N-phenyl and N-benzyl substituted succinimides: Preclinical evaluation for their antihypertensive effect and underlying mechanism.
    Eur J Pharmacol. 2023 Dec 22:176195. doi: 10.1016/j.ejphar.2023.176195.
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  54. HUANG J, Xie Y, Chen B, Xia Y, et al
    GPR146 regulates pulmonary vascular remodeling by promoting pulmonary artery smooth muscle cell proliferation through 5-lipoxygenase.
    Eur J Pharmacol. 2023;961:176123.
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  55. LI D, Chen Y, Wang Y, Liu J, et al
    NAMPT mediates PDGF-induced pulmonary arterial smooth muscle cell proliferation by TLR4/NF-kappaB/PLK4 signaling pathway.
    Eur J Pharmacol. 2023;961:176151.
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  56. SILVA-VELASCO DL, Hong E, Beltran-Ornelas JH, Sanchez-Lopez A, et al
    Hydrogen sulfide ameliorates hypertension and vascular dysfunction induced by insulin resistance in rats by reducing oxidative stress and activating eNOS.
    Eur J Pharmacol. 2023 Dec 12:176266. doi: 10.1016/j.ejphar.2023.176266.
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  57. MANEESAI P, Potue P, Khamseekaew J, Sangartit W, et al
    Kaempferol protects against cardiovascular abnormalities induced by nitric oxide deficiency in rats by suppressing the TNF-alpha pathway.
    Eur J Pharmacol. 2023;960:176112.
    >> Share

  58. XU Q, Zhuo K, Zhang X, Zhen Y, et al
    The role of angiotensin II activation of yes-associated protein/PDZ-binding motif signaling in hypertensive cardiac and vascular remodeling.
    Eur J Pharmacol. 2023 Dec 5:176252. doi: 10.1016/j.ejphar.2023.176252.
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    November 2023
  59. VAN DORST DCH, Mirabito Colafella KM, van Veghel R, Garrelds IM, et al
    Cyclooxygenase-2 inhibition prevents renal toxicity but not hypertension during sunitinib treatment.
    Eur J Pharmacol. 2023 Nov 27:176199. doi: 10.1016/j.ejphar.2023.176199.
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  60. HO CY, Sun GC, Lin YT, Wong TY, et al
    Microglial activation and toll-like receptor 4-Dependent regulation of angiotensin II type I receptor-mu-opioid receptor 1 heterodimerization and hypertension in fructose-fed rats.
    Eur J Pharmacol. 2023 Nov 21:176171. doi: 10.1016/j.ejphar.2023.176171.
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  61. MATSUMOTO T, Taguchi K, Kobayashi T
    Role of TRPV4 on vascular tone regulation in pathophysiological states.
    Eur J Pharmacol. 2023;959:176104.
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  62. EDOSUYI O, Igbe I, Oyekan A
    Fumarate and its downstream signalling pathways in the cardiorenal system: Recent insights and novel expositions in the etiology of hypertension.
    Eur J Pharmacol. 2023 Nov 7:176186. doi: 10.1016/j.ejphar.2023.176186.
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  63. YI Y, Tianxin Y, Zhangchi L, Cui Z, et al
    Pinocembrin attenuates susceptibility to atrial fibrillation in rats with pulmonary arterial hypertension.
    Eur J Pharmacol. 2023;960:176169.
    >> Share

    October 2023
  64. KONG S, Yu J, Li HF, Xie YL, et al
    A ring N(CH(3))(2)-based derivative of resveratrol inhibits pulmonary vascular remodeling in hypoxia pulmonary hypertension.
    Eur J Pharmacol. 2023 Oct 9:176077. doi: 10.1016/j.ejphar.2023.176077.
    >> Share

    September 2023
  65. NOAH AA, El-Mezayen NS, El-Ganainy SO, Darwish IE, et al
    Reversal of fibrosis and portal hypertension by Empagliflozin treatment of CCl(4)-induced liver fibrosis: Emphasis on gal-1/NRP-1/TGF-beta and gal-1/NRP-1/VEGFR2 pathways.
    Eur J Pharmacol. 2023 Sep 26:176066. doi: 10.1016/j.ejphar.2023.176066.
    >> Share

  66. VALOVIC P, Behuliak M, Vaneckova I, Zicha J, et al
    Impaired vascular beta-adrenergic relaxation in spontaneously hypertensive rats: The differences between conduit and resistance arteries.
    Eur J Pharmacol. 2023 Sep 12:176045. doi: 10.1016/j.ejphar.2023.176045.
    >> Share


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