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Herpes simplex Infection

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Articles published in
J Virol
    September 2025
  1. VILLANI VP, Espinoza JA, Drayman N
    HSV-1 progeny production by individual human keratinocytes spans three orders of magnitude.
    J Virol. 2025;99:e0113825.
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  2. DUNN G, Domanico LF, Taylor MP
    The producer cell type of HSV-1 alters the proteomic contents and infectious capacity of virions.
    J Virol. 2025;99:e0082925.
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    August 2025
  3. HEATH JR, Lloyd AE, Kulinski RM, Fromuth DP, et al
    Camptothecin, a topoisomerase I inhibitor, impedes productive herpes simplex virus type 1 infection.
    J Virol. 2025 Aug 28:e0127625. doi: 10.1128/jvi.01276.
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    June 2025
  4. SHIO S, Kato A, Kawasaki J, Takeshima K, et al
    Impact of the changes in substrate specificity of herpes simplex virus 1 protein kinase Us3 on viral infection in vitro and in vivo.
    J Virol. 2025 Jun 30:e0040025. doi: 10.1128/jvi.00400.
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  5. WANG S, Jaggi U, Oh JJ, Ghiasi H, et al
    IFNbeta absence compensates for LAT functions in latency reactivation and T cell exhaustion.
    J Virol. 2025;99:e0037425.
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    April 2025
  6. JONES C
    Human alpha-herpesvirus 1 (HSV-1) viral replication and reactivation from latency are expedited by the glucocorticoid receptor.
    J Virol. 2025;99:e0030325.
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  7. HARRISON KS, Cowan SR, Jones C
    Murine nasal-associated lymphoid tissue (NALT) harbors human alphaherpesvirus 1 (HSV-1) DNA during latency, and dexamethasone triggers viral replication.
    J Virol. 2025;99:e0225124.
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  8. WEISS E, Whisnant AW, Hennig T, Djakovic L, et al
    HSV-1 infection induces a downstream shift of the +1 nucleosome.
    J Virol. 2025;99:e0208624.
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  9. QIU L, Gao X, Shao X, Xi J, et al
    HSV-1 UL56 protein recruits cellular NEDD4-family ubiquitin ligases to suppress CD1d expression and NKT cell function.
    J Virol. 2025;99:e0214024.
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  10. CHENTOUFI AA, Prakash S, Vahed H, Karan S, et al
    A tissue-targeted prime/pull/keep therapeutic herpes simplex virus vaccine protects against recurrent ocular herpes infection and disease in HLA-A*0201 transgenic rabbits.
    J Virol. 2025 Apr 10:e0013525. doi: 10.1128/jvi.00135.
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    March 2025
  11. HULL MA, Pritchard SM, Nicola AV
    Herpes simplex virus 1 envelope glycoprotein C shields glycoprotein D to protect virions from entry-blocking antibodies.
    J Virol. 2025 Mar 26:e0009025. doi: 10.1128/jvi.00090.
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  12. KALAMVOKI M
    HSV-1 virions and related particles: biogenesis and implications in the infection.
    J Virol. 2025;99:e0107624.
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    February 2025
  13. RICHARDO T, Liu X, Dohner K, Chao T-Y, et al
    Herpes simplex virus assembly and spread in murine skin after infection from the outside.
    J Virol. 2025 Feb 13:e0163824. doi: 10.1128/jvi.01638.
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    November 2024
  14. NIEMEYER CS, Merle L, Bubak AN, Baxter BD, et al
    Olfactory and trigeminal routes of HSV-1 CNS infection with regional microglial heterogeneity.
    J Virol. 2024;98:e0096824.
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  15. MULLON PJ, Maldonado-Luevano E, Mehta KPM, Mohni KN, et al
    The herpes simplex virus alkaline nuclease is required to maintain replication fork progression.
    J Virol. 2024 Nov 7:e0183624. doi: 10.1128/jvi.01836.
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    October 2024
  16. SINGH N, Zachariah S, Phillips AT, Tscharke D, et al
    Lytic promoter activity during herpes simplex virus latency is dependent on genome location.
    J Virol. 2024 Oct 21:e0125824. doi: 10.1128/jvi.01258.
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    September 2024
  17. WHISNANT AW, Dyck Dionisi O, Salazar Sanchez V, Rappold JM, et al
    Herpes simplex virus 1 inhibits phosphorylation of RNA polymerase II CTD serine-7.
    J Virol. 2024 Sep 24:e0117824. doi: 10.1128/jvi.01178.
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    August 2024
  18. FINNEN RL, Muradov JH, Le Sage V, Banfield BW, et al
    Disruption of herpes simplex virus type 2 pUL21 phosphorylation impairs secondary envelopment of cytoplasmic nucleocapsids.
    J Virol. 2024 Aug 13:e0065624. doi: 10.1128/jvi.00656.
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  19. BERGEMAN MH, Velarde K, Hargis HL, Glenn HL, et al
    The Rab6 post-Golgi secretory pathway contributes to herpes simplex virus 1 (HSV-1) egress.
    J Virol. 2024 Aug 13:e0059924. doi: 10.1128/jvi.00599.
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    July 2024
  20. LIU S, Maruzuru Y, Takeshima K, Koyanagi N, et al
    Impact of the interaction between herpes simplex virus 1 ICP22 and FACT on viral gene expression and pathogenesis.
    J Virol. 2024 Jul 17:e0073724. doi: 10.1128/jvi.00737.
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    June 2024
  21. WHITE S, Roller R
    Herpes simplex virus type-1 cVAC formation in neuronal cells is mediated by dynein motor function and glycoprotein retrieval from the plasma membrane.
    J Virol. 2024 Jun 20:e0071324. doi: 10.1128/jvi.00713.
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  22. HSU Z-S, Engel EA, Enquist LW, Koyuncu OO, et al
    Neuronal expression of herpes simplex virus-1 VP16 protein induces pseudorabies virus escape from silencing and reactivation.
    J Virol. 2024 Jun 13:e0056124. doi: 10.1128/jvi.00561.
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  23. WANG S, Song X, Rajewski A, Santiskulvong C, et al
    Ample evidence for the presence of HSV-1 LAT in non-neuronal ganglionic cells of mice and humans.
    J Virol. 2024;98:e0044124.
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  24. OUWENDIJK WJD, Roychoudhury P, Cunningham AL, Jerome KR, et al
    Reply to Wang et al., "Ample evidence for the presence of HSV-1 LAT in non-neuronal ganglionic cells of mice and humans".
    J Virol. 2024;98:e0052024.
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    May 2024
  25. KATO A, Iwasaki R, Takeshima K, Maruzuru Y, et al
    Identification of a novel neurovirulence factor encoded by the cryptic orphan gene UL31.6 of herpes simplex virus 1.
    J Virol. 2024 May 31:e0074724. doi: 10.1128/jvi.00747.
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  26. BIRKENHEUER CH, Baines JD
    Aberrant RNA polymerase initiation and processivity on the genome of a herpes simplex virus 1 mutant lacking ICP27.
    J Virol. 2024 May 23:e0071224. doi: 10.1128/jvi.00712.
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    April 2024
  27. DOMANICO LF, Dunn GP, Kobiler O, Taylor MP, et al
    A dual fluorescent herpes simplex virus type 1 recombinant reveals divergent outcomes of neuronal infection.
    J Virol. 2024 Apr 23:e0003224. doi: 10.1128/jvi.00032.
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  28. QUADIRI A, Prakash S, Dhanushkodi NR, Singer M, et al
    Therapeutic prime/pull vaccination of HSV-2-infected guinea pigs with the ribonucleotide reductase 2 (RR2) protein and CXCL11 chemokine boosts antiviral local tissue-resident and effector memory CD4(+) and CD8(+) T cells and protects against recurrent
    J Virol. 2024 Apr 8:e0159623. doi: 10.1128/jvi.01596.
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    March 2024
  29. JAGGI U, Matundan HH, Oh JJ, Ghiasi H, et al
    Absence of CD80 reduces HSV-1 replication in the eye and delays reactivation but not latency levels.
    J Virol. 2024;98:e0201023.
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  30. OUWENDIJK WJD, Roychoudhury P, Cunningham AL, Jerome KR, et al
    Reanalysis of single-cell RNA sequencing data does not support herpes simplex virus 1 latency in non-neuronal ganglionic cells in mice.
    J Virol. 2024 Mar 6:e0185823. doi: 10.1128/jvi.01858.
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    February 2024
  31. DOCHNAL SA, Whitford AL, Francois AK, Krakowiak PA, et al
    c-Jun signaling during initial HSV-1 infection modulates latency to enhance later reactivation in addition to directly promoting the progression to full reactivation.
    J Virol. 2024;98:e0176423.
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    January 2024
  32. BERGEMAN MH, Hernandez MQ, Diefenderfer J, Drewes JA, et al
    Individual herpes simplex virus 1 (HSV-1) particles exit by exocytosis and accumulate at preferential egress sites.
    J Virol. 2024 Jan 9:e0178523. doi: 10.1128/jvi.01785.
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    December 2023
  33. GRAMS TR, Edwards TG, Bloom DC
    A viral lncRNA tethers HSV-1 genomes at the nuclear periphery to establish viral latency.
    J Virol. 2023;97:e0143823.
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    November 2023
  34. VELUSAMY T, Singh N, Croft S, Smith S, et al
    The expression and function of HSV ICP47 and its promoter in mice.
    J Virol. 2023;97:e0110723.
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    October 2023
  35. WAISNER H, Lasnier S, Suma SM, Kalamvoki M, et al
    Effects on exocytosis by two HSV-1 mutants unable to block autophagy.
    J Virol. 2023;97:e0075723.
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  36. ZUBKOVIC A, Gomes C, Parchure A, Cesarec M, et al
    HSV-1 miRNAs are post-transcriptionally edited in latently infected human ganglia.
    J Virol. 2023;97:e0073023.
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  37. YOU H, Lin Y, Lin F, Yang M, et al
    Correction for You et al., "beta-Catenin Is Required for the cGAS/STING Signaling Pathway but Antagonized by the Herpes Simplex Virus 1 US3 Protein".
    J Virol. 2023 Oct 16:e0098423. doi: 10.1128/jvi.00984.
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  38. YUAN H, You J, You H, Zheng C, et al
    Correction for Yuan et al., "Herpes Simplex Virus 1 UL36USP Antagonizes Type I Interferon-Mediated Antiviral Innate Immunity".
    J Virol. 2023 Oct 16:e0098323. doi: 10.1128/jvi.00983.
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  39. HUANG J, You H, Su C, Li Y, et al
    Correction for Huang et al., "Herpes Simplex Virus 1 Tegument Protein VP22 Abrogates cGAS/STING-Mediated Antiviral Innate Immunity".
    J Virol. 2023 Oct 16:e0098223. doi: 10.1128/jvi.00982.
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  40. ZHENG C
    Correction for Zheng, "Evasion of Cytosolic DNA-Stimulated Innate Immune Responses by Herpes Simplex Virus 1".
    J Virol. 2023 Oct 16:e0098123. doi: 10.1128/jvi.00981.
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  41. HARRISON KS, Wijesekera N, Robinson AGJ, Santos VC, et al
    Impaired glucocorticoid receptor function attenuates herpes simplex virus 1 production during explant-induced reactivation from latency in female mice.
    J Virol. 2023 Oct 12:e0130523. doi: 10.1128/jvi.01305.
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    September 2023
  42. BOURNE N, Keith CA, Miller AL, Pyles RB, et al
    Boosting of vaginal HSV-2-specific B and T cell responses by intravaginal therapeutic immunization results in diminished recurrent HSV-2 disease.
    J Virol. 2023;97:e0066923.
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  43. DUNN LEM, Baines JD
    Herpes simplex virus 1 immediate early transcription initiation, pause-release, elongation, and termination in the presence and absence of ICP4.
    J Virol. 2023 Sep 27:e0096023. doi: 10.1128/jvi.00960.
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    June 2023
  44. SANDERS LS 3RD, Comar CE, Srinivas KP, Lalli J, et al
    Herpes Simplex Virus-1 ICP27 Nuclear Export Signal Mutants Exhibit Cell Type-Dependent Deficits in Replication and ICP4 Expression.
    J Virol. 2023 Jun 13:e0195722. doi: 10.1128/jvi.01957.
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  45. DE LA CRUZ NC, Mockel M, Niehues H, Rubsam M, et al
    Ex Vivo Infection of Human Skin Models with Herpes Simplex Virus 1: Accessibility of the Receptor Nectin-1 during Formation or Impairment of Epidermal Barriers Is Restricted by Tight Junctions.
    J Virol. 2023 Jun 8:e0026223. doi: 10.1128/jvi.00262.
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    May 2023
  46. WEISS E, Hennig T, Grassl P, Djakovic L, et al
    HSV-1 Infection Induces a Downstream Shift of Promoter-Proximal Pausing for Host Genes.
    J Virol. 2023;97:e0038123.
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    April 2023
  47. CUDDY SR, Cliffe AR
    The Intersection of Innate Immune Pathways with the Latent Herpes Simplex Virus Genome.
    J Virol. 2023 Apr 27:e0135222. doi: 10.1128/jvi.01352.
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  48. SANTOS VC, Ostler JB, Harrison KS, Jones C, et al
    Slug, a Stress-Induced Transcription Factor, Stimulates Herpes Simplex Virus 1 Replication and Transactivates a cis-Regulatory Module within the VP16 Promoter.
    J Virol. 2023 Apr 6:e0007323. doi: 10.1128/jvi.00073.
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    February 2023
  49. WANG J, Qin X, Huang Y, Zhang G, et al
    Sirt1 Negatively Regulates Cellular Antiviral Responses by Preventing the Cytoplasmic Translocation of Interferon-Inducible Protein 16 in Human Cells.
    J Virol. 2023;97:e0197522.
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  50. GRAMS TR, Edwards TG, Bloom DC
    HSV-1 LAT Promoter Deletion Viruses Exhibit Strain-Specific and LAT-Dependent Epigenetic Regulation of Latent Viral Genomes in Human Neurons.
    J Virol. 2023;97:e0193522.
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