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Herpes simplex Infection
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Articles published in
PLoS Pathog
    October 2026
  1. FRIETZE S, Lunn C, Oldham D, Boyd JR, et al
    Intranasal HSV?1 infection drives region?specific interferon?dominant microglial remodeling.
    PLoS Pathog. 2026;22:e1014684.
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    September 2026
  2. ZIMENKO A, Hayman I, Fong Y, Monroe LD, et al
    Epithelial interferon-gamma responsiveness shapes chemokine induction and clinical outcomes in herpes simplex virus infection.
    PLoS Pathog. 2026;22:e1014612.
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  3. BIRKENHEUER CH, Edwards TG, Bloom DC, Baines JD, et al
    Analysis of host and viral nascent and steady-state RNA levels in a human neuronal model of herpes simplex virus 1 infection.
    PLoS Pathog. 2026;22:e1014603.
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  4. ARYA D, Tormanen K, Oh JJ, Wang S, et al
    Complete disruption of gD binding to HVEM alters virus replication and host receptor homeostasis.
    PLoS Pathog. 2026;22:e1014566.
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  5. JAGGI U, Wang S, Ghiasi H
    Epigenetic profiling reveals M1 macrophages as the primary drivers of trained immunity in HSV-1 latently infected mice.
    PLoS Pathog. 2026;22:e1014598.
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    July 2026
  6. KONIGHOFER E, Gustafsson C, Gudmundsdotter L, Mirgorodskaya E, et al
    Glycoprotein G enables HSV-2 neuroinvasion and provides protection as a glycosylated vaccine antigen.
    PLoS Pathog. 2026;22:e1014339.
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  7. ZHAO Y, Probert S, Birkel J, Liu X, et al
    Independent proviral and antiviral host factors recognize the same capsid protein in divergent human herpesviruses.
    PLoS Pathog. 2026;22:e1014376.
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    June 2026
  8. TIAN X, Wang X, Wang S, Zhong Y, et al
    SUMOylation and ubiquitination reciprocally regulate SMCHD1 antiviral activity against herpes simplex virus 1.
    PLoS Pathog. 2026;22:e1014371.
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  9. JAKI L, Full F, Gieraths U, Falcone V, et al
    Low frequency variants can predetermine antiviral drug resistance development in herpes simplex virus type 1.
    PLoS Pathog. 2026;22:e1014296.
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  10. HOOK LM, Cairns TM, Awasthi S, Egan KP, et al
    HSV-2 gC2 mRNA immunization in mice protects by producing antibodies that bind immune evasion epitopes.
    PLoS Pathog. 2026;22:e1014337.
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    May 2026
  11. ARYA D, Jaggi U, Oh JJ, Wang S, et al
    Partial or complete blocking of gD binding to HVEM affects primary and latent HSV-1 infection as well as eye disease in HSV-1 infected mice.
    PLoS Pathog. 2026;22:e1014258.
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    January 2026
  12. TERVONEN A, Ruokolainen V, Leclerc S, Tieu K, et al
    Nucleus softens during herpesvirus infection.
    PLoS Pathog. 2026;22:e1013873.
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    November 2025
  13. JAGGI U, Hirose S, Wang S, Ghiasi H, et al
    Divergent roles of macrophage subsets, FoxP3, and IL-17A in HSV-1-induced CNS pathology.
    PLoS Pathog. 2025;21:e1013696.
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    August 2025
  14. ROBERTS APE, Orr A, Iliev V, Orr L, et al
    Daxx mediated histone H3.3 deposition on HSV-1 DNA restricts genome decompaction and the progression of immediate-early transcription.
    PLoS Pathog. 2025;21:e1012501.
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    May 2025
  15. ARSHAD S, Rana H, Truong NR, Pattamatta U, et al
    Herpes simplex virus type-1 infection and spread in a novel porcine corneal explant model is restricted to the epithelium.
    PLoS Pathog. 2025;21:e1013162.
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  16. ALBANO C, Trifiro L, Hewelt-Belka W, Cairns DM, et al
    The impact of fatty acid synthase on HSV-1 infection dynamics.
    PLoS Pathog. 2025;21:e1013068.
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    April 2025
  17. PARCHURE A, Cesarec M, Braut A, Kolman R, et al
    ADAR1 p150 prevents HSV-1 from triggering PKR/eIF2alpha-mediated translational arrest and is required for efficient viral replication.
    PLoS Pathog. 2025;21:e1012452.
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    February 2025
  18. DUTTON AJ, Turnbaugh EM, Patel CD, Garland CR, et al
    Asymptomatic neonatal herpes simplex virus infection in mice leads to persistent CNS infection and long-term cognitive impairment.
    PLoS Pathog. 2025;21:e1012935.
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    October 2024
  19. WANG S, Jaggi U, Katsumata M, Ghiasi H, et al
    The importance of IFNalpha2A (Roferon-A) in HSV-1 latency and T cell exhaustion in ocularly infected mice.
    PLoS Pathog. 2024;20:e1012612.
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  20. SINGH P, Zhu L, Shipley MA, Ye ZA, et al
    The HSV-1 encoded CCCTC-binding factor, CTRL2, impacts the nature of viral chromatin during HSV-1 lytic infection.
    PLoS Pathog. 2024;20:e1012621.
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    September 2024
  21. WANG K, Jordan T, Dowdell K, Herbert R, et al
    A nonhuman primate model for genital herpes simplex virus 2 infection that results in vaginal vesicular lesions, virus shedding, and seroconversion.
    PLoS Pathog. 2024;20:e1012477.
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    June 2024
  22. RANA H, Truong NR, Johnson B, Baharlou H, et al
    Herpes simplex virus spreads rapidly in human foreskin, partly driven by chemokine-induced redistribution of Nectin-1 on keratinocytes.
    PLoS Pathog. 2024;20:e1012267.
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  23. YANG C, Wang CY, Long QY, Cao Z, et al
    The roles of nuclear orphan receptor NR2F6 in anti-viral innate immunity.
    PLoS Pathog. 2024;20:e1012271.
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    April 2024
  24. LECLERC S, Gupta A, Ruokolainen V, Chen JH, et al
    Progression of herpesvirus infection remodels mitochondrial organization and metabolism.
    PLoS Pathog. 2024;20:e1011829.
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    December 2023
  25. THOMAS ECM, Finnen RL, Mewburn JD, Archer SL, et al
    The Herpes Simplex Virus pUL16 and pUL21 Proteins Prevent Capsids from Docking at Nuclear Pore Complexes.
    PLoS Pathog. 2023;19:e1011832.
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  26. PASQUERO S, Gugliesi F, Biolatti M, Dell'Oste V, et al
    Citrullination profile analysis reveals peptidylarginine deaminase 3 as an HSV-1 target to dampen the activity of candidate antiviral restriction factors.
    PLoS Pathog. 2023;19:e1011849.
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    July 2023
  27. PACKARD JE, Williams MR, Fromuth DP, Dembowski JA, et al
    Proliferating cell nuclear antigen inhibitors block distinct stages of herpes simplex virus infection.
    PLoS Pathog. 2023;19:e1011539.
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  28. FU Y, Zhan X, You X, Nie D, et al
    USP12 promotes antiviral responses by deubiquitinating and stabilizing IFI16.
    PLoS Pathog. 2023;19:e1011480.
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  29. XUE Q, Zhu Z, Xue Z, Yang F, et al
    NOG1 downregulates type I interferon production by targeting phosphorylated interferon regulatory factor 3.
    PLoS Pathog. 2023;19:e1011511.
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    June 2023
  30. PHEASANT K, Perry D, Wise EL, Cheng V, et al
    Dysregulated metabolism of the late herpes simplex virus 1 transcriptome through the vhs-VP22 axis uncouples virus cytopathic effect and virus production.
    PLoS Pathog. 2023;19:e1010966.
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