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Head and Neck Cancer

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Articles published in
Proc Natl Acad Sci U S A
    August 2026
  1. WANG X, Zhou Y, Tan J, Zhang D, et al
    USP14 competitively binds to FBXW7 to stabilize MTDH and promotes metastasis and drug resistance of head and neck squamous cell carcinoma.
    Proc Natl Acad Sci U S A. 2026;123:e2504068123.
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  2. SHINN CK, Saddawi-Konefka R, Salanga CL, Schokrpur S, et al
    Exploiting the CXCR3/CXCL10 axis overrides tumor immune suppression by enhancing immune trafficking and effector cell priming in HNSCC.
    Proc Natl Acad Sci U S A. 2026;123:e2522360123.
    >> Share

  3. WOLFE CA, Mendes TV, Jackobs F, Bench S, et al
    Adapting the MasSpec Pen for noninvasive detection of oral cavity squamous cell carcinoma.
    Proc Natl Acad Sci U S A. 2026;123:e2603602123.
    >> Share

    March 2026
  4. ASIEDU EB, Kumar A, Choi A, Luciano DO, et al
    Targeting the ANGPTL4/NRP1/ABL1/RAD51 axis reverses cisplatin resistance by impairing DNA damage repair in head and neck cancer.
    Proc Natl Acad Sci U S A. 2026;123:e2510265123.
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  5. KHALIL MI, Wang J, Vu L, Yang C, et al
    The membrane-associated ubiquitin ligase MARCHF8 degrades MHC-I in HPV-positive head and neck cancer for immune evasion.
    Proc Natl Acad Sci U S A. 2026;123:e2525730123.
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    January 2026
  6. TAN L, Zhou H, Zhang B, Kwong DLW, et al
    Multiomics identifies a cholesterol-TFEB-PLD3-TLR9 axis driving immunosuppressive tumor-associated macrophage polarization in esophageal squamous cell carcinoma.
    Proc Natl Acad Sci U S A. 2026;123:e2520427123.
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  7. SU ZF, Wu CZ, Ding HR, Zhan Q, et al
    Spatially resolved multiomics reveals the self-enforcing property of the leading-edge multicellular ecosystem of head and neck cancer.
    Proc Natl Acad Sci U S A. 2026;123:e2519474123.
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    December 2025
  8. WANG F, Wong IYH, Liu H, Wu Z, et al
    Guiding esophagectomy with intraoperative NIR-II fluorescence video imaging and rapid computation.
    Proc Natl Acad Sci U S A. 2025;122:e2517785122.
    >> Share

  9. JANG J, Ko KP, Zhang J, Jun S, et al
    Deciphering precursor cell dynamics in esophageal preneoplasia via genetic barcoding and single-cell transcriptomics.
    Proc Natl Acad Sci U S A. 2025;122:e2509534122.
    >> Share

    July 2025
  10. PECORARI R, Mancini M, Smirnov A, Corleone G, et al
    p63 and ZNF148 cooperate to regulate head and neck squamous cell carcinoma.
    Proc Natl Acad Sci U S A. 2025;122:e2500579122.
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    April 2025
  11. LI SS, Zhang B, Huang C, Fu Y, et al
    FAO-fueled OXPHOS and NRF2-mediated stress resilience in MICs drive lymph node metastasis.
    Proc Natl Acad Sci U S A. 2025;122:e2411241122.
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    February 2025
  12. WANG T, Wang X, Wang K, Yu M, et al
    Chronic stress-induced cholesterol metabolism abnormalities promote ESCC tumorigenesis and predict neoadjuvant therapy response.
    Proc Natl Acad Sci U S A. 2025;122:e2415042122.
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    December 2024
  13. BERNABE-RUBIO M, Watt FM
    Caspase-8-dependent autophagy regulates neutrophil infiltration in oral squamous cell carcinoma.
    Proc Natl Acad Sci U S A. 2024;121:e2406944121.
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    October 2024
  14. WEI JR, Zhang B, Zhang Y, Chen WM, et al
    QSOX1 facilitates dormant esophageal cancer stem cells to evade immune elimination via PD-L1 upregulation and CD8 T cell exclusion.
    Proc Natl Acad Sci U S A. 2024;121:e2407506121.
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    June 2024
  15. NAM C, Li LY, Yang Q, Ziman B, et al
    A druggable cascade links methionine metabolism to epigenomic reprogramming in squamous cell carcinoma.
    Proc Natl Acad Sci U S A. 2024;121:e2320835121.
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    March 2024
  16. GALLINSON DG, Kozakiewicz CP, Rautsaw RM, Beer MA, et al
    Intergenomic signatures of coevolution between Tasmanian devils and an infectious cancer.
    Proc Natl Acad Sci U S A. 2024;121:e2307780121.
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    February 2024
  17. SHIN E, Kwon Y, Jung E, Kim YJ, et al
    TM4SF19 controls GABP-dependent YAP transcription in head and neck cancer under oxidative stress conditions.
    Proc Natl Acad Sci U S A. 2024;121:e2314346121.
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    October 2023
  18. LIU B, Zhang B, Qi J, Zhou H, et al
    Targeting MFGE8 secreted by cancer-associated fibroblasts blocks angiogenesis and metastasis in esophageal squamous cell carcinoma.
    Proc Natl Acad Sci U S A. 2023;120:e2307914120.
    >> Share


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