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J Clin Invest
    February 2021
    Research gaps in medical treatment of transgender/nonbinary people.
    J Clin Invest. 2021;131.
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  2. TEBAS P, Jadlowsky JK, Shaw PA, Tian L, et al
    CCR5-edited CD4 T cells augment HIV-specific immunity to enable post rebound control of HIV replication.
    J Clin Invest. 2021 Feb 11. pii: 144486. doi: 10.1172/JCI144486.
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  3. MATSUDA K, Migueles SA, Huang J, Bolkhovitinov L, et al
    A replication competent adenovirus-vectored influenza vaccine induces durable systemic and mucosal immunity.
    J Clin Invest. 2021 Feb 2. pii: 140794. doi: 10.1172/JCI140794.
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    January 2021
  4. SWANSTROM AE, Immonen TT, Oswald K, Pyle C, et al
    Antibody-mediated depletion of viral reservoirs is limited in SIV-infected macaques treated early with antiretroviral therapy.
    J Clin Invest. 2021 Jan 19. pii: 142421. doi: 10.1172/JCI142421.
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    December 2020
  5. SIMONETTI FR, Zhang H, Soroosh GP, Duan J, et al
    Antigen-driven clonal selection shapes the persistence of HIV-1 infected CD4+ T cells in vivo.
    J Clin Invest. 2020 Dec 10. pii: 145254. doi: 10.1172/JCI145254.
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  6. PILLAY BA, Fusaro M, Gray PE, Statham AL, et al
    Somatic reversion of pathogenic DOCK8 variants alters lymphocyte differentiation and function to effectively cure DOCK8 deficiency.
    J Clin Invest. 2020 Dec 8. pii: 142434. doi: 10.1172/JCI142434.
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    October 2020
  7. HALVAS EK, Joseph KW, Brandt LD, Guo S, et al
    HIV-1 viremia not suppressible by antiretroviral therapy can originate from large T cell clones producing infectious virus.
    J Clin Invest. 2020 Oct 5. pii: 138099. doi: 10.1172/JCI138099.
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  8. SILICIANO JD, Siliciano RF
    Nonsuppressible HIV-1 viremia: a reflection of how the reservoir persists.
    J Clin Invest. 2020 Oct 5. pii: 141497. doi: 10.1172/JCI141497.
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  9. PEREZ-DIEZ A, Wong CS, Liu X, Mystakelis H, et al
    Prevalence and pathogenicity of autoantibodies in patients with idiopathic CD4 lymphopenia.
    J Clin Invest. 2020;130:5326-5337.
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    September 2020
  10. IGNATIUS EH, Cohen KA, Bishai WR
    Getting to the point in point-of-care diagnostics for tuberculosis.
    J Clin Invest. 2020 Sep 28. pii: 142497. doi: 10.1172/JCI142497.
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  11. DUKE ER, Williamson BD, Borate B, Golob JL, et al
    Cytomegalovirus viral load kinetics as surrogate endpoints after allogeneic transplantation.
    J Clin Invest. 2020 Sep 24. pii: 133960. doi: 10.1172/JCI133960.
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    August 2020
  12. LI H, Omange RW, Liang B, Toledo N, et al
    Vaccine targeting SIVmac251 protease cleavage sites protects macaques against vaginal infection.
    J Clin Invest. 2020 Aug 27. pii: 138728. doi: 10.1172/JCI138728.
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    Treatment of latent M. tuberculosis infection and use of antiretroviral therapy to prevent tuberculosis.
    J Clin Invest. 2020 Aug 24. pii: 137294. doi: 10.1172/JCI137294.
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    July 2020
  14. BROGER T, Nicol M, Sigal G, Gotuzzo E, et al
    Diagnostic accuracy of three urine lipoarabinomannan tuberculosis assays in HIV-negative outpatients.
    J Clin Invest. 2020 Jul 21. pii: 140461. doi: 10.1172/JCI140461.
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  15. WU F, Ourmanov I, Kirmaier A, Leviyang S, et al
    SIV infection duration largely determines broadening of neutralizing antibody response in macaques.
    J Clin Invest. 2020 Jul 14. pii: 139123. doi: 10.1172/JCI139123.
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  16. DUFOUR C, Gantner P, Fromentin R, Chomont N, et al
    The multifaceted nature of HIV latency.
    J Clin Invest. 2020;130:3381-3390.
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    June 2020
  17. TUYISHIME M, Garrido C, Jha S, Moeser M, et al
    Improved Killing of HIV-infected Cells Using Three Neutralizing and Non-neutralizing Antibodies.
    J Clin Invest. 2020 Jun 25. pii: 135557. doi: 10.1172/JCI135557.
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  18. YEH YJ, Jenike KM, Calvi RM, Chiarella J, et al
    Filgotinib suppresses HIV-1-driven gene transcription by inhibiting HIV-1 splicing and T cell activation.
    J Clin Invest. 2020 Jun 23. pii: 137371. doi: 10.1172/JCI137371.
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  19. GANATRA SR, Bucsan AN, Alvarez X, Kumar S, et al
    Anti-retroviral therapy does not reduce tuberculosis reactivation in a tuberculosis-HIV co-infection model.
    J Clin Invest. 2020 Jun 16. pii: 136502. doi: 10.1172/JCI136502.
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  20. POTHLICHET J, Rose T, Bugault F, Jeammet L, et al
    PLA2G1B is involved in CD4 anergy and CD4 lymphopenia in HIV-infected patients.
    J Clin Invest. 2020;130:2872-2887.
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    May 2020
  21. DORHOI A, Kotze LA, Berzofsky JA, Sui Y, et al
    Therapies for tuberculosis and AIDS: myeloid-derived suppressor cells in focus.
    J Clin Invest. 2020 May 18. pii: 136288. doi: 10.1172/JCI136288.
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    April 2020
  22. COHN LB, Deeks SG
    The immune response fails to control HIV early in initial virus spread.
    J Clin Invest. 2020 Apr 27. pii: 136886. doi: 10.1172/JCI136886.
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    March 2020
  23. ANTAR AAR, Jenike KM, Jang S, Rigau DN, et al
    Longitudinal study reveals HIV-1-infected CD4+ T cell dynamics during long-term antiretroviral therapy.
    J Clin Invest. 2020 Mar 19. pii: 135953. doi: 10.1172/JCI135953.
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  24. CALE EM, Bai H, Bose M, Messina MA, et al
    Neutralizing antibody VRC01 failed to select for HIV-1 mutations upon viral rebound.
    J Clin Invest. 2020 Mar 17. pii: 134395. doi: 10.1172/JCI134395.
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  25. DINARDO A, Rajapakshe K, Nishiguchi T, Mtetwa G, et al
    DNA hyper-methylation during Tuberculosis dampens host immune responsiveness.
    J Clin Invest. 2020 Mar 3. pii: 134622. doi: 10.1172/JCI134622.
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    February 2020
    The gift of a lifetime: analysis of HIV at autopsy.
    J Clin Invest. 2020 Feb 24. pii: 135905. doi: 10.1172/JCI135905.
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  27. RENIA L, Grau GE, Wassmer SC
    CD8+ T cells and human cerebral malaria: a shifting episteme.
    J Clin Invest. 2020 Feb 17. pii: 135510. doi: 10.1172/JCI135510.
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  28. REN Y, Huang SH, Patel S, Conce Alberto WD, et al
    BCL-2 antagonism sensitizes cytotoxic t cell-resistant hiv reservoirs to elimination ex vivo.
    J Clin Invest. 2020 Feb 6. pii: 132374. doi: 10.1172/JCI132374.
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  29. MITCHELL JL, Takata H, Muir R, Colby DJ, et al
    Plasmacytoid dendritic cells sense HIV replication before detectable viremia following treatment interruption.
    J Clin Invest. 2020 Feb 4. pii: 130597. doi: 10.1172/JCI130597.
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    January 2020
  30. CHAILLON A, Gianella S, Dellicour S, Rawlings SA, et al
    HIV persists throughout deep tissues with repopulation from multiple anatomical sources.
    J Clin Invest. 2020 Jan 7. pii: 134815. doi: 10.1172/JCI134815.
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    December 2019
  31. RIGGLE BA, Manglani M, Maric D, Johnson KR, et al
    CD8+ T cells target cerebrovasculature in children with cerebral malaria.
    J Clin Invest. 2019 Dec 10. pii: 133474. doi: 10.1172/JCI133474.
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    November 2019
  32. OGONGO P, Steyn AJ, Karim F, Dullabh KJ, et al
    Differential skewing of donor-unrestricted and gammadelta T cell repertoires in tuberculosis-infected human lungs.
    J Clin Invest. 2019 Nov 25. pii: 130711. doi: 10.1172/JCI130711.
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  33. KULICKE CA, Lewinsohn DA, Lewinsohn DM
    Clonal enrichments of Vdelta2- gammadelta T cells in Mycobacterium tuberculosis-infected human lungs.
    J Clin Invest. 2019 Nov 25. pii: 133119. doi: 10.1172/JCI133119.
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  34. SCULLY EP, Weld ED, Blankson JN
    Challenges in optimizing preexposure prophylaxis development, engagement, and access for HIV prevention.
    J Clin Invest. 2019 Nov 11. pii: 134389. doi: 10.1172/JCI134389.
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  35. HE T, Xu C, Krampe N, Dillon SM, et al
    High-fat diet exacerbates SIV pathogenesis and accelerates disease progression.
    J Clin Invest. 2019 Nov 11. pii: 121208. doi: 10.1172/JCI121208.
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  36. WISE MC, Xu Z, Tello-Ruiz E, Beck C, et al
    In vivo delivery of synthetic DNA-encoded antibodies induces broad HIV-1-neutralizing activity.
    J Clin Invest. 2019 Nov 7. pii: 132779. doi: 10.1172/JCI132779.
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    October 2019
  37. STARKE CE, Vinton CL, Ladell K, McLaren JE, et al
    SIV-specific CD8+ T cells are clonotypically distinct across lymphoid and mucosal tissues.
    J Clin Invest. 2019 Oct 29. pii: 129161. doi: 10.1172/JCI129161.
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  38. BLAZKOVA J, Refsland EW, Clarridge KE, Shi V, et al
    Glycan-dependent HIV-specific neutralizing antibodies bind to cells of uninfected individuals.
    J Clin Invest. 2019 Oct 7. pii: 125955. doi: 10.1172/JCI125955.
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  39. CHARLES TP, Derdeyn CA
    Striking a balance in an antibody network: A roadmap for HIV-1 vaccines.
    J Clin Invest. 2019 Oct 7. pii: 132535. doi: 10.1172/JCI132535.
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  40. NEIDICH SD, Fong Y, Li SS, Geraghty DE, et al
    Antibody Fc effector functions and IgG3 associate with decreased HIV-1 risk.
    J Clin Invest. 2019 Oct 7. pii: 126391. doi: 10.1172/JCI126391.
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    September 2019
    Simplified steps to heterologous prime-boost HIV vaccine development?
    J Clin Invest. 2019 Sep 30. pii: 132440. doi: 10.1172/JCI132440.
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  42. ROUPHAEL NG, Morgan C, Li SS, Jensen R, et al
    DNA priming and gp120 boosting induces HIV-specific antibodies in a randomized clinical trial.
    J Clin Invest. 2019 Sep 30. pii: 128699. doi: 10.1172/JCI128699.
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  43. BUCSAN AN, Chatterjee A, Singh DK, Foreman TW, et al
    Mechanisms of reactivation of latent tuberculosis infection due to SIV co-infection.
    J Clin Invest. 2019 Sep 3. pii: 125810. doi: 10.1172/JCI125810.
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    July 2019
  44. MCMANUS WR, Bale MJ, Spindler J, Wiegand A, et al
    HIV-1 in lymph nodes is maintained by cellular proliferation during antiretroviral therapy.
    J Clin Invest. 2019;130.
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  45. NIU Q, Liu Z, Alamer E, Fan X, et al
    Structure-guided drug design identifies a BRD4-selective small molecule that suppresses HIV.
    J Clin Invest. 2019;130.
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  46. LI T, Ju E, Gao SJ
    Kaposi sarcoma-associated herpesvirus miRNAs suppress CASTOR1-mediated mTORC1 inhibition to promote tumorigenesis.
    J Clin Invest. 2019;130.
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  47. SPUDICH S, Robertson KR, Bosch RJ, Gandhi RT, et al
    Persistent HIV-infected cells in cerebrospinal fluid are associated with poorer neurocognitive performance.
    J Clin Invest. 2019;130.
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    Is successful HIV therapy a Pyrrhic victory for the brain?
    J Clin Invest. 2019;130.
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    June 2019
  49. MARTIN MD, Jensen IJ, Ishizuka AS, Lefebvre M, et al
    Bystander responses impact accurate detection of murine and human antigen-specific CD8 T cells.
    J Clin Invest. 2019;130.
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    April 2019
  50. SHEHU AI, Lu J, Wang P, Zhu J, et al
    Pregnane X receptor activation potentiates ritonavir hepatotoxicity.
    J Clin Invest. 2019;130.
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    February 2019
  51. SUI Y, Lewis GK, Wang Y, Berckmueller K, et al
    Mucosal vaccine efficacy against intrarectal SHIV is independent of anti-Env antibody response.
    J Clin Invest. 2019 Feb 18. pii: 122110. doi: 10.1172/JCI122110.
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    January 2019
  52. EINKAUF KB, Lee GQ, Gao C, Sharaf R, et al
    Intact HIV-1 proviruses accumulate at distinct chromosomal positions during prolonged antiretroviral therapy.
    J Clin Invest. 2019 Jan 28. pii: 124291. doi: 10.1172/JCI124291.
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  53. STONE NR, Rhodes J, Fisher MC, Mfinanga S, et al
    Dynamic ploidy changes drive fluconazole resistance in human cryptococcal meningitis.
    J Clin Invest. 2019 Jan 28. pii: 124516. doi: 10.1172/JCI124516.
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    December 2018
  54. PERCIANI CT, Farah B, Kaul R, Ostrowski MA, et al
    Live-attenuated varicella zoster virus vaccine does not induce HIV target cell activation.
    J Clin Invest. 2018 Dec 4. pii: 124473. doi: 10.1172/JCI124473.
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    November 2018
  55. FORTHAL D, Finzi A
    Blocking HIV-1 replication: are Fc-Fcgamma receptor interactions required?
    J Clin Invest. 2018 Nov 26. pii: 125264. doi: 10.1172/JCI125264.
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  56. PARSONS MS, Lee WS, Kristensen AB, Amarasena T, et al
    Fc-dependent functions are redundant to efficacy of anti-HIV antibody PGT121 in macaques.
    J Clin Invest. 2018 Nov 26. pii: 122466. doi: 10.1172/JCI122466.
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    October 2018
  57. YOUNES SA, Talla A, Pereira Ribeiro S, Saidakova EV, et al
    Cycling CD4+ T cells in HIV-infected immune nonresponders have mitochondrial dysfunction.
    J Clin Invest. 2018 Oct 15. pii: 120245. doi: 10.1172/JCI120245.
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  58. CHAND HS, Vazquez-Guillamet R, Royer CM, Rudolph K, et al
    Cigarette smoke and HIV synergistically affect lung pathology in cynomolgus macaques.
    J Clin Invest. 2018 Oct 2. pii: 121935. doi: 10.1172/JCI121935.
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    September 2018
  59. ZALENSKAYA IA, Chandra N, Yousefieh N, Fang X, et al
    Use of contraceptive depot medroxyprogesterone acetate is associated with impaired cervicovaginal mucosal integrity.
    J Clin Invest. 2018 Sep 17. pii: 120583. doi: 10.1172/JCI120583.
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  60. SIVANANDHAM R, Brocca-Cofano E, Krampe N, Falwell E, et al
    Neutrophil extracellular trap production contributes to pathogenesis in SIV-infected nonhuman primates.
    J Clin Invest. 2018 Sep 11. pii: 99420. doi: 10.1172/JCI99420.
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  61. KANDATHIL AJ, Sugawara S, Goyal A, Durand CM, et al
    No recovery of replication-competent HIV-1 from human liver macrophages.
    J Clin Invest. 2018 Sep 10. pii: 121678. doi: 10.1172/JCI121678.
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    August 2018
  62. CHENG L, Wang Q, Li G, Banga R, et al
    TLR3 agonist and CD40-targeting vaccination induces immune responses and reduces HIV-1 reservoirs.
    J Clin Invest. 2018 Aug 27. pii: 99005. doi: 10.1172/JCI99005.
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    July 2018
  63. SHARAF R, Lee GQ, Sun X, Etemad B, et al
    HIV-1 proviral landscapes distinguish posttreatment controllers from noncontrollers.
    J Clin Invest. 2018 Jul 19. pii: 120549. doi: 10.1172/JCI120549.
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  64. CAUCHETEUX S, Piguet V
    Vaginal epidermal dendritic cells: defense against HIV-1 or a safe haven?
    J Clin Invest. 2018 Jul 9. pii: 121744. doi: 10.1172/JCI121744.
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    June 2018
  65. SALANTES DB, Zheng Y, Mampe F, Srivastava T, et al
    HIV-1 latent reservoir size and diversity are stable following brief treatment interruption.
    J Clin Invest. 2018 Jun 18. pii: 120194. doi: 10.1172/JCI120194.
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  66. MOYSI E, Pallikkuth S, De Armas LR, Gonzalez LE, et al
    Altered immune cell follicular dynamics in HIV infection following influenza vaccination.
    J Clin Invest. 2018 Jun 18. pii: 99884. doi: 10.1172/JCI99884.
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  67. HONEYCUTT JB, Liao B, Nixon CC, Cleary RA, et al
    T cells establish and maintain CNS viral infection in HIV-infected humanized mice.
    J Clin Invest. 2018 Jun 4. pii: 98968. doi: 10.1172/JCI98968.
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    May 2018
  68. CARDONE M, Garcia K, Tilahun ME, Boyd LF, et al
    A transgenic mouse model for HLA-B*57:01-linked abacavir drug tolerance and reactivity.
    J Clin Invest. 2018 May 21. pii: 99321. doi: 10.1172/JCI99321.
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  69. KITYO C, Makamdop KN, Rothenberger M, Chipman JG, et al
    Lymphoid tissue fibrosis is associated with impaired vaccine responses.
    J Clin Invest. 2018 May 21. pii: 97377. doi: 10.1172/JCI97377.
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  70. PENA-CRUZ V, Agosto LM, Akiyama H, Olson A, et al
    HIV-1 replicates and persists in vaginal epithelial dendritic cells.
    J Clin Invest. 2018 May 3. pii: 98943. doi: 10.1172/JCI98943.
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    April 2018
    Tandem bispecific broadly neutralizing antibody - a novel approach to HIV-1 treatment.
    J Clin Invest. 2018 Apr 23. pii: 121078. doi: 10.1172/JCI121078.
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  72. FERRANDO-MARTINEZ S, Moysi E, Pegu A, Andrews S, et al
    Accumulation of follicular CD8+ T cells in pathogenic SIV infection.
    J Clin Invest. 2018 Apr 16. pii: 96207. doi: 10.1172/JCI96207.
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    March 2018
  73. LAFORGE M, Silvestre R, Rodrigues V, Garibal J, et al
    The anti-caspase inhibitor Q-VD-OPH prevents AIDS disease progression in SIV-infected rhesus macaques.
    J Clin Invest. 2018 Mar 19. pii: 95127. doi: 10.1172/JCI95127.
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    February 2018
  74. MARTIN MP, Naranbhai V, Shea PR, Qi Y, et al
    Killer cell immunoglobulin-like receptor 3DL1 variation modifies HLA-B*57 protection against HIV-1.
    J Clin Invest. 2018 Feb 20. pii: 98463. doi: 10.1172/JCI98463.
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  75. WU X, Guo J, Niu M, An M, et al
    Tandem bispecific neutralizing antibody eliminates HIV-1 infection in humanized mice.
    J Clin Invest. 2018 Feb 20. pii: 96764. doi: 10.1172/JCI96764.
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  76. JIANG G, Nguyen D, Archin NM, Yukl SA, et al
    HIV latency is reversed by ACSS2-driven histone crotonylation.
    J Clin Invest. 2018 Feb 19. pii: 98071. doi: 10.1172/JCI98071.
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    January 2018
  77. HUANG SH, Ren Y, Thomas AS, Chan D, et al
    Latent HIV reservoirs exhibit inherent resistance to elimination by CD8+ T cells.
    J Clin Invest. 2018 Jan 22. pii: 97555. doi: 10.1172/JCI97555.
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    October 2017
  78. VEENHUIS RT, Freeman ZT, Korleski J, Cohen LK, et al
    HIV-antibody complexes enhance production of type I interferon by plasmacytoid dendritic cells.
    J Clin Invest. 2017 Oct 30. pii: 95375. doi: 10.1172/JCI95375.
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    September 2017
  79. VAN ZYL GU, Katusiime MG, Wiegand A, McManus WR, et al
    No evidence of HIV replication in children on antiretroviral therapy.
    J Clin Invest. 2017 Sep 11. pii: 94582. doi: 10.1172/JCI94582.
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