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HIV Infection

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Articles published in
PLoS Pathog
    November 2021
  1. TAYLOR RA, McRaven MD, Carias AM, Anderson MR, et al
    Localization of infection in neonatal rhesus macaques after oral viral challenge.
    PLoS Pathog. 2021;17:e1009855.
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  2. ADRIANO VIEIRA V, Adland E, Malone DFG, Martin MP, et al
    An HLA-I signature favouring KIR-educated Natural Killer cells mediates immune control of HIV in children and contrasts with the HLA-B-restricted CD8+ T-cell-mediated immune control in adults.
    PLoS Pathog. 2021;17:e1010090.
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  3. ZHAO Z, Fagerlund R, Tossavainen H, Hopfensperger K, et al
    Evolutionary plasticity of SH3 domain binding by Nef proteins of the HIV-1/SIVcpz lentiviral lineage.
    PLoS Pathog. 2021;17:e1009728.
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  4. MIELKE D, Bandawe G, Zheng J, Jones J, et al
    ADCC-mediating non-neutralizing antibodies can exert immune pressure in early HIV-1 infection.
    PLoS Pathog. 2021;17:e1010046.
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  5. ADENIJI OS, Kuri-Cervantes L, Yu C, Xu Z, et al
    Siglec-9 defines and restrains a natural killer subpopulation highly cytotoxic to HIV-infected cells.
    PLoS Pathog. 2021;17:e1010034.
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    October 2021
  6. MARTIN MM, Matkovic R, Larrous P, Morel M, et al
    Binding to DCAF1 distinguishes TASOR and SAMHD1 degradation by HIV-2 Vpx.
    PLoS Pathog. 2021;17:e1009609.
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  7. KMIEC D, Lista MJ, Ficarelli M, Swanson CM, et al
    S-farnesylation is essential for antiviral activity of the long ZAP isoform against RNA viruses with diverse replication strategies.
    PLoS Pathog. 2021;17:e1009726.
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  8. CROOKS ET, Almanza F, D'Addabbo A, Duggan E, et al
    Engineering well-expressed, V2-immunofocusing HIV-1 envelope glycoprotein membrane trimers for use in heterologous prime-boost vaccine regimens.
    PLoS Pathog. 2021;17:e1009807.
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  9. NGUYEN K, Dobrowolski C, Shukla M, Cho WK, et al
    Inhibition of the H3K27 demethylase UTX enhances the epigenetic silencing of HIV proviruses and induces HIV-1 DNA hypermethylation but fails to permanently block HIV reactivation.
    PLoS Pathog. 2021;17:e1010014.
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    September 2021
  10. MISHRA N, Kumar S, Singh S, Bansal T, et al
    Cross-neutralization of SARS-CoV-2 by HIV-1 specific broadly neutralizing antibodies and polyclonal plasma.
    PLoS Pathog. 2021;17:e1009958.
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  11. ALJEDANI SS, Liban TJ, Tran K, Phad G, et al
    Structurally related but genetically unrelated antibody lineages converge on an immunodominant HIV-1 Env neutralizing determinant following trimer immunization.
    PLoS Pathog. 2021;17:e1009543.
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  12. LUSTIG G, Cele S, Karim F, Derache A, et al
    T cell derived HIV-1 is present in the CSF in the face of suppressive antiretroviral therapy.
    PLoS Pathog. 2021;17:e1009871.
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  13. GUEDAN A, Donaldson CD, Caroe ER, Cosnefroy O, et al
    HIV-1 requires capsid remodelling at the nuclear pore for nuclear entry and integration.
    PLoS Pathog. 2021;17:e1009484.
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  14. MBONYE U, Leskov K, Shukla M, Valadkhan S, et al
    Biogenesis of P-TEFb in CD4+ T cells to reverse HIV latency is mediated by protein kinase C (PKC)-independent signaling pathways.
    PLoS Pathog. 2021;17:e1009581.
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    August 2021
  15. VAN SCHOOTEN J, van Haaren MM, Li H, McCoy LE, et al
    Antibody responses induced by SHIV infection are more focused than those induced by soluble native HIV-1 envelope trimers in non-human primates.
    PLoS Pathog. 2021;17:e1009736.
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  16. JOHNSON EL, Swieboda D, Olivier A, Enninga EAL, et al
    Robust innate immune responses at the placenta during early gestation may limit in utero HIV transmission.
    PLoS Pathog. 2021;17:e1009860.
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  17. KOYUNCU D, Niazi MKK, Tavolara T, Abeijon C, et al
    CXCL1: A new diagnostic biomarker for human tuberculosis discovered using Diversity Outbred mice.
    PLoS Pathog. 2021;17:e1009773.
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  18. CORLEY MJ, Sacdalan C, Pang AP, Chomchey N, et al
    Abrupt and altered cell-type specific DNA methylation profiles in blood during acute HIV infection persists despite prompt initiation of ART.
    PLoS Pathog. 2021;17:e1009785.
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  19. ZHUKOVA A, Voznica J, Davila Felipe M, To TH, et al
    Cuban history of CRF19 recombinant subtype of HIV-1.
    PLoS Pathog. 2021;17:e1009786.
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  20. YU L, Majerciak V, Xue XY, Uberoi A, et al
    Mouse papillomavirus type 1 (MmuPV1) DNA is frequently integrated in benign tumors by microhomology-mediated end-joining.
    PLoS Pathog. 2021;17:e1009812.
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  21. PINO M, Pereira Ribeiro S, Pagliuzza A, Ghneim K, et al
    Increased homeostatic cytokines and stability of HIV-infected memory CD4 T-cells identify individuals with suboptimal CD4 T-cell recovery on-ART.
    PLoS Pathog. 2021;17:e1009825.
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    July 2021
  22. KERVEVAN J, Bouteau A, Lanza JS, Hammoudi A, et al
    Targeting human langerin promotes HIV-1 specific humoral immune responses.
    PLoS Pathog. 2021;17:e1009749.
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  23. BISWAS A, Zhou D, Fiches GN, Wu Z, et al
    Inhibition of polo-like kinase 1 (PLK1) facilitates reactivation of gamma-herpesviruses and their elimination.
    PLoS Pathog. 2021;17:e1009764.
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  24. WEN J, Cheever T, Wang L, Wu D, et al
    Improved delivery of broadly neutralizing antibodies by nanocapsules suppresses SHIV infection in the CNS of infant rhesus macaques.
    PLoS Pathog. 2021;17:e1009738.
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  25. BARRENAS F, Hansen SG, Law L, Driscoll C, et al
    Interleukin-15 response signature predicts RhCMV/SIV vaccine efficacy.
    PLoS Pathog. 2021;17:e1009278.
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  26. MAEHIGASHI T, Ahn S, Kim UI, Lindenberger J, et al
    A highly potent and safe pyrrolopyridine-based allosteric HIV-1 integrase inhibitor targeting host LEDGF/p75-integrase interaction site.
    PLoS Pathog. 2021;17:e1009671.
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  27. CHAKHTOURA M, Fang M, Cubas R, O'Connor MH, et al
    Germinal Center T follicular helper (GC-Tfh) cell impairment in chronic HIV infection involves c-Maf signaling.
    PLoS Pathog. 2021;17:e1009732.
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    June 2021
  28. LEE MY, Upadhyay AA, Walum H, Chan CN, et al
    Tissue-specific transcriptional profiling of plasmacytoid dendritic cells reveals a hyperactivated state in chronic SIV infection.
    PLoS Pathog. 2021;17:e1009674.
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  29. MCDONNELL MM, Karvonen SC, Gaba A, Flath B, et al
    Highly-potent, synthetic APOBEC3s restrict HIV-1 through deamination-independent mechanisms.
    PLoS Pathog. 2021;17:e1009523.
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  30. IMMONEN TT, Fennessey CM, Lipkey L, Thorpe A, et al
    Transient viral replication during analytical treatment interruptions in SIV infected macaques can alter the rebound-competent viral reservoir.
    PLoS Pathog. 2021;17:e1009686.
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  31. CAI F, Chen WH, Wu W, Jones JA, et al
    Structural and genetic convergence of HIV-1 neutralizing antibodies in vaccinated non-human primates.
    PLoS Pathog. 2021;17:e1009624.
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  32. TAYLOR RA, Xiao S, Carias AM, McRaven MD, et al
    PET/CT targeted tissue sampling reveals virus specific dIgA can alter the distribution and localization of HIV after rectal exposure.
    PLoS Pathog. 2021;17:e1009632.
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  33. WONG YC, Liu W, Yim LY, Li X, et al
    Sustained viremia suppression by SHIVSF162P3CN-recalled effector-memory CD8+ T cells after PD1-based vaccination.
    PLoS Pathog. 2021;17:e1009647.
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    May 2021
  34. BULLINGTON BW, Klemperer K, Mages K, Chalem A, et al
    Effects of schistosomes on host anti-viral immune response and the acquisition, virulence, and prevention of viral infections: A systematic review.
    PLoS Pathog. 2021;17:e1009555.
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  35. WOOD MP, Jones CI, Lippy A, Oliver BG, et al
    Rapid progression is associated with lymphoid follicle dysfunction in SIV-infected infant rhesus macaques.
    PLoS Pathog. 2021;17:e1009575.
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  36. COOMER CA, Carlon-Andres I, Iliopoulou M, Dustin ML, et al
    Correction: Single-cell glycolytic activity regulates membrane tension and HIV-1 fusion.
    PLoS Pathog. 2021;17:e1009584.
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  37. BOCHART RM, Busman-Sahay K, Bondoc S, Morrow DW, et al
    Mitigation of endemic GI-tract pathogen-mediated inflammation through development of multimodal treatment regimen and its impact on SIV acquisition in rhesus macaques.
    PLoS Pathog. 2021;17:e1009565.
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    April 2021
  38. SHAPIRO M, Krug LT, MacCarthy T
    Mutational pressure by host APOBEC3s more strongly affects genes expressed early in the lytic phase of herpes simplex virus-1 (HSV-1) and human polyomavirus (HPyV) infection.
    PLoS Pathog. 2021;17:e1009560.
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  39. BERTRAM KM, Truong NR, Smith JB, Kim M, et al
    Herpes Simplex Virus type 1 infects Langerhans cells and the novel epidermal dendritic cell, Epi-cDC2s, via different entry pathways.
    PLoS Pathog. 2021;17:e1009536.
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  40. RINALDI S, de Armas L, Dominguez-Rodriguez S, Pallikkuth S, et al
    T cell immune discriminants of HIV reservoir size in a pediatric cohort of perinatally infected individuals.
    PLoS Pathog. 2021;17:e1009533.
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  41. GONCALVES-CARNEIRO D, Takata MA, Ong H, Shilton A, et al
    Origin and evolution of the zinc finger antiviral protein.
    PLoS Pathog. 2021;17:e1009545.
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  42. TONG O, Duette G, O'Neil TR, Royle CM, et al
    Plasmacytoid dendritic cells have divergent effects on HIV infection of initial target cells and induce a pro-retention phenotype.
    PLoS Pathog. 2021;17:e1009522.
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  43. ARMANI-TOURRET M, Zhou Z, Gasser R, Staropoli I, et al
    Mechanisms of HIV-1 evasion to the antiviral activity of chemokine CXCL12 indicate potential links with pathogenesis.
    PLoS Pathog. 2021;17:e1009526.
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  44. TRIANTAFILOU K, Ward CJK, Czubala M, Ferris RG, et al
    Differential recognition of HIV-stimulated IL-1beta and IL-18 secretion through NLR and NAIP signalling in monocyte-derived macrophages.
    PLoS Pathog. 2021;17:e1009417.
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  45. KUMAR R, Deshpande S, Sewall LM, Ozorowski G, et al
    Elicitation of potent serum neutralizing antibody responses in rabbits by immunization with an HIV-1 clade C trimeric Env derived from an Indian elite neutralizer.
    PLoS Pathog. 2021;17:e1008977.
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  46. COFFIN JM, Bale MJ, Wells D, Guo S, et al
    Integration in oncogenes plays only a minor role in determining the in vivo distribution of HIV integration sites before or during suppressive antiretroviral therapy.
    PLoS Pathog. 2021;17:e1009141.
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  47. KUMAR A, Giorgi EE, Tu JJ, Martinez DR, et al
    Mutations that confer resistance to broadly-neutralizing antibodies define HIV-1 variants of transmitting mothers from that of non-transmitting mothers.
    PLoS Pathog. 2021;17:e1009478.
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  48. ZHEN A, Carrillo MA, Mu W, Rezek V, et al
    Robust CAR-T memory formation and function via hematopoietic stem cell delivery.
    PLoS Pathog. 2021;17:e1009404.
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    March 2021
  49. LUCENA LAGE S, Wong CS, Pinheiro Amaral E, Sturdevant D, et al
    Classical complement and inflammasome activation converge in CD14highCD16- monocytes in HIV associated TB-immune reconstitution inflammatory syndrome.
    PLoS Pathog. 2021;17:e1009435.
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  50. LEE CD, Watanabe Y, Wu NC, Han J, et al
    A cross-neutralizing antibody between HIV-1 and influenza virus.
    PLoS Pathog. 2021;17:e1009407.
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  51. CHEN S, Kumar S, Espada CE, Tirumuru N, et al
    N6-methyladenosine modification of HIV-1 RNA suppresses type-I interferon induction in differentiated monocytic cells and primary macrophages.
    PLoS Pathog. 2021;17:e1009421.
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  52. SOWD GA, Aiken C
    Correction: Inositol phosphates promote HIV-1 assembly and maturation to facilitate viral spread in human CD4+ T cells.
    PLoS Pathog. 2021;17:e1009389.
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  53. MDLULI T, Jian N, Slike B, Paquin-Proulx D, et al
    Correction: RV144 HIV-1 vaccination impacts post-infection antibody responses.
    PLoS Pathog. 2021;17:e1009386.
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  54. ANDERSEN-NISSEN E, Fiore-Gartland A, Ballweber Fleming L, Carpp LN, et al
    Innate immune signatures to a partially-efficacious HIV vaccine predict correlates of HIV-1 infection risk.
    PLoS Pathog. 2021;17:e1009363.
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  55. ROLLAND M, Gilbert PB
    Sieve analysis to understand how SARS-CoV-2 diversity can impact vaccine protection.
    PLoS Pathog. 2021;17:e1009406.
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    February 2021
  56. JEFFERYS SR, Burgos SD, Peterson JJ, Selitsky SR, et al
    Epigenomic characterization of latent HIV infection identifies latency regulating transcription factors.
    PLoS Pathog. 2021;17:e1009346.
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  57. BRUCE JW, Bracken M, Evans E, Sherer N, et al
    ZBTB2 represses HIV-1 transcription and is regulated by HIV-1 Vpr and cellular DNA damage responses.
    PLoS Pathog. 2021;17:e1009364.
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  58. HSU DC, Schuetz A, Imerbsin R, Silsorn D, et al
    TLR7 agonist, N6-LS and PGT121 delayed viral rebound in SHIV-infected macaques after antiretroviral therapy interruption.
    PLoS Pathog. 2021;17:e1009339.
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  59. GAO Y, He S, Tian W, Li D, et al
    First complete-genome documentation of HIV-1 intersubtype superinfection with transmissions of diverse recombinants over time to five recipients.
    PLoS Pathog. 2021;17:e1009258.
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  60. CHARLES TP, Burton SL, Arunachalam PS, Cottrell CA, et al
    The C3/465 glycan hole cluster in BG505 HIV-1 envelope is the major neutralizing target involved in preventing mucosal SHIV infection.
    PLoS Pathog. 2021;17:e1009257.
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  61. RENNER N, Mallery DL, Faysal KMR, Peng W, et al
    A lysine ring in HIV capsid pores coordinates IP6 to drive mature capsid assembly.
    PLoS Pathog. 2021;17:e1009164.
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  62. DINKELE R, Gessner S, McKerry A, Leonard B, et al
    Capture and visualization of live Mycobacterium tuberculosis bacilli from tuberculosis patient bioaerosols.
    PLoS Pathog. 2021;17:e1009262.
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    January 2021
  63. SOWD GA, Aiken C
    Inositol phosphates promote HIV-1 assembly and maturation to facilitate viral spread in human CD4+ T cells.
    PLoS Pathog. 2021;17:e1009190.
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  64. BACCHUS-SOUFFAN C, Fitch M, Symons J, Abdel-Mohsen M, et al
    Relationship between CD4 T cell turnover, cellular differentiation and HIV persistence during ART.
    PLoS Pathog. 2021;17:e1009214.
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  65. CARLIN E, Greer B, Lowman K, Duverger A, et al
    Extensive proteomic and transcriptomic changes quench the TCR/CD3 activation signal of latently HIV-1 infected T cells.
    PLoS Pathog. 2021;17:e1008748.
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  66. SANTIAGO JC, Goldman JD, Zhao H, Pankow AP, et al
    Intra-host changes in Kaposi sarcoma-associated herpesvirus genomes in Ugandan adults with Kaposi sarcoma.
    PLoS Pathog. 2021;17:e1008594.
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  67. SHRESTHA P, Davis DA, Jaeger HK, Stream A, et al
    Pomalidomide restores immune recognition of primary effusion lymphoma through upregulation of ICAM-1 and B7-2.
    PLoS Pathog. 2021;17:e1009091.
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    December 2020
  68. AKAHOSHI T, Gatanaga H, Kuse N, Chikata T, et al
    T-cell responses to sequentially emerging viral escape mutants shape long-term HIV-1 population dynamics.
    PLoS Pathog. 2020;16:e1009177.
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  69. UPADHYAY C, Feyznezhad R, Cao L, Chan KW, et al
    Signal peptide of HIV-1 envelope modulates glycosylation impacting exposure of V1V2 and other epitopes.
    PLoS Pathog. 2020;16:e1009185.
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  70. NOEL-ROMAS L, Perner M, Molatlhegi R, Farr Zuend C, et al
    Vaginal microbiome-hormonal contraceptive interactions associate with the mucosal proteome and HIV acquisition.
    PLoS Pathog. 2020;16:e1009097.
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  71. WINANS S, Goff SP
    Mutations altering acetylated residues in the CTD of HIV-1 integrase cause defects in proviral transcription at early times after integration of viral DNA.
    PLoS Pathog. 2020;16:e1009147.
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  72. KHAMASSI M, Xu L, Rey J, Duchemin M, et al
    The CH1alpha domain of mucosal gp41 IgA contributes to antibody specificity and antiviral functions in HIV-1 highly exposed Sero-Negative individuals.
    PLoS Pathog. 2020;16:e1009103.
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  73. MDLULI T, Jian N, Slike B, Paquin-Proulx D, et al
    RV144 HIV-1 vaccination impacts post-infection antibody responses.
    PLoS Pathog. 2020;16:e1009101.
    >> Share

  74. WU NC, Yuan M, Bangaru S, Huang D, et al
    A natural mutation between SARS-CoV-2 and SARS-CoV determines neutralization by a cross-reactive antibody.
    PLoS Pathog. 2020;16:e1009089.
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  75. LI Z, Hajian C, Greene WC
    Identification of unrecognized host factors promoting HIV-1 latency.
    PLoS Pathog. 2020;16:e1009055.
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  76. CHEU RK, Gustin AT, Lee C, Schifanella L, et al
    Impact of vaginal microbiome communities on HIV antiretroviral-based pre-exposure prophylaxis (PrEP) drug metabolism.
    PLoS Pathog. 2020;16:e1009024.
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    November 2020
  77. MORON-LOPEZ S, Telwatte S, Sarabia I, Battivelli E, et al
    Human splice factors contribute to latent HIV infection in primary cell models and blood CD4+ T cells from ART-treated individuals.
    PLoS Pathog. 2020;16:e1009060.
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  78. GODOT V, Tcherakian C, Gil L, Cervera-Marzal I, et al
    TLR-9 agonist and CD40-targeting vaccination induces HIV-1 envelope-specific B cells with a diversified immunoglobulin repertoire in humanized mice.
    PLoS Pathog. 2020;16:e1009025.
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  79. TAHER H, Mahyari E, Kreklywich C, Uebelhoer LS, et al
    In vitro and in vivo characterization of a recombinant rhesus cytomegalovirus containing a complete genome.
    PLoS Pathog. 2020;16:e1008666.
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  80. GELBART M, Harari S, Ben-Ari Y, Kustin T, et al
    Drivers of within-host genetic diversity in acute infections of viruses.
    PLoS Pathog. 2020;16:e1009029.
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  81. GOSWAMI R, Berendam SJ, Li SH, Nelson AN, et al
    Harnessing early life immunity to develop a pediatric HIV vaccine that can protect through adolescence.
    PLoS Pathog. 2020;16:e1008983.
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  82. CARTER JJ, Gardner JM, Poling BP, Welch MM, et al
    Transcriptional analysis of immune response genes during pathogenesis of cytomegalovirus retinitis in mice with murine acquired immunodeficiency syndrome.
    PLoS Pathog. 2020;16:e1009032.
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    October 2020
  83. TRYPSTEEN W, Van Cleemput J, Snippenberg WV, Gerlo S, et al
    On the whereabouts of SARS-CoV-2 in the human body: A systematic review.
    PLoS Pathog. 2020;16:e1009037.
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  84. BRICKER KM, Obregon-Perko V, Uddin F, Williams B, et al
    Therapeutic vaccination of SIV-infected, ART-treated infant rhesus macaques using Ad48/MVA in combination with TLR-7 stimulation.
    PLoS Pathog. 2020;16:e1008954.
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  85. FRENCH AJ, Natesampillai S, Krogman A, Correia C, et al
    Reactivating latent HIV with PKC agonists induces resistance to apoptosis and is associated with phosphorylation and activation of BCL2.
    PLoS Pathog. 2020;16:e1008906.
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  86. GUO K, Shen G, Kibbie J, Gonzalez T, et al
    Qualitative Differences Between the IFNalpha subtypes and IFNbeta Influence Chronic Mucosal HIV-1 Pathogenesis.
    PLoS Pathog. 2020;16:e1008986.
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  87. SAHA B, Chisholm D, Kell AM, Mandell MA, et al
    A non-canonical role for the autophagy machinery in anti-retroviral signaling mediated by TRIM5alpha.
    PLoS Pathog. 2020;16:e1009017.
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  88. BOWMAN ER, Cameron CM, Richardson B, Kulkarni M, et al
    Macrophage maturation from blood monocytes is altered in people with HIV, and is linked to serum lipid profiles and activation indices: A model for studying atherogenic mechanisms.
    PLoS Pathog. 2020;16:e1008869.
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  89. GENOULA M, Marin Franco JL, Maio M, Dolotowicz B, et al
    Fatty acid oxidation of alternatively activated macrophages prevents foam cell formation, but Mycobacterium tuberculosis counteracts this process via HIF-1alpha activation.
    PLoS Pathog. 2020;16:e1008929.
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  90. DAS J, Devadhasan A, Linde C, Broge T, et al
    Mining for humoral correlates of HIV control and latent reservoir size.
    PLoS Pathog. 2020;16:e1008868.
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    September 2020
  91. PANIGRAHI S, Chen B, Fang M, Potashnikova D, et al
    CX3CL1 and IL-15 Promote CD8 T cell chemoattraction in HIV and in atherosclerosis.
    PLoS Pathog. 2020;16:e1008885.
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  92. KRASNOPOLSKY S, Kuzmina A, Taube R
    Genome-wide CRISPR knockout screen identifies ZNF304 as a silencer of HIV transcription that promotes viral latency.
    PLoS Pathog. 2020;16:e1008834.
    >> Share

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