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Drug Resistance
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Articles published in
Proc Natl Acad Sci U S A
    July 2026
  1. SARKIS AW, Sorensen JL, Sondergaard TE, Nielsen KL, et al
    An activity-resistance trade-off constrains enzyme evolution.
    Proc Natl Acad Sci U S A. 2026;123:e2602068123.
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  2. KELLY ETR, Myziuk I, Hemmings MZ, Mulla Z, et al
    Hydration and hydrolysis define antibiotic resistance conferred by macrolide esterases.
    Proc Natl Acad Sci U S A. 2026;123:e2611077123.
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    June 2026
  3. CHEN F, Peng Y, Zhu Y, Xie H, et al
    Counterselection against beta-lactamase-expressing bacteria via an activatable photosensitizer that accumulates in resistant pathogens.
    Proc Natl Acad Sci U S A. 2026;123:e2536405123.
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  4. BOTTACIN G, Raach B, Frohlich L, Kunnecke J, et al
    Opposing range-dependent interactions create complex spatial patterns of antibiotic tolerance in multispecies biofilms.
    Proc Natl Acad Sci U S A. 2026;123:e2604163123.
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  5. SHANNON A, Fattorini V, Sartre C, Chazot A, et al
    Consecutive catalytic steps of viral RNA polymerase and exonuclease suggest a way to overcome intrinsic nucleotide analogue resistance.
    Proc Natl Acad Sci U S A. 2026;123:e2605725123.
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  6. WU X, Jin L, Wang Q, Wang R, et al
    TadA-mediated A-to-I mRNA editing rewires redox metabolism to promote dominance of epidemic Klebsiella pneumoniae clones.
    Proc Natl Acad Sci U S A. 2026;123:e2536397123.
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  7. MONNAPPA S, Al-Mayyah Z, Sakar MS, Persat A, et al
    Growth in confinement promotes Pseudomonas aeruginosa tolerance to antibiotics.
    Proc Natl Acad Sci U S A. 2026;123:e2605176123.
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    April 2026
  8. COLOMER-WINTER C, Nair ZJ, Chua JYJ, Jabli S, et al
    A two-component system signaling hub controls enterococcal membrane remodeling in response to daptomycin.
    Proc Natl Acad Sci U S A. 2026;123:e2532437123.
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    March 2026
  9. SHEN LQ, Wang L, Yao Z, Lin D, et al
    Phages drive the dissemination of antibiotic resistance genes by facilitating host adaptation to heavy metal stress.
    Proc Natl Acad Sci U S A. 2026;123:e2535653123.
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    January 2026
  10. MCDONOUGH LD, Li S, Munsamy-Govender V, Gwin CM, et al
    An activator of a two-component system controls cell separation and intrinsic drug resistance in Mycobacterium tuberculosis.
    Proc Natl Acad Sci U S A. 2026;123:e2519608123.
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  11. HERNANDEZ-BIRD J, He B, VanOtterloo LM, Billings EB, et al
    Resistance, heteroresistance, and fitness costs drive colistin treatment failure during Acinetobacter baumannii pneumonia.
    Proc Natl Acad Sci U S A. 2026;123:e2515303123.
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    December 2025
  12. MILLER ST, Henzler-Wildman KA, Raman S
    Energetic and structural control of polyspecificity in a multidrug transporter.
    Proc Natl Acad Sci U S A. 2025;122:e2511892122.
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  13. TRAN PM, Anaya-Sanchez A, Ji DX, Schwarz MCR, et al
    Cell envelope maintenance by PhoP is essential for Mycobacterium tuberculosis methylglyoxal resistance.
    Proc Natl Acad Sci U S A. 2025;122:e2523024122.
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  14. ANGELES-SOLANO M, Tabashsum Z, Liu JD, Lifschin ZJ, et al
    Antibiotics accumulate in Klebsiella pneumoniae liver abscesses but fail to eliminate antibiotic-tolerant populations.
    Proc Natl Acad Sci U S A. 2025;122:e2524436122.
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  15. SCHINDL A, Jones ME, Ghimire L, Kalverda AP, et al
    Inhibition of fusidic acid resistance through restricting conformational flexibility in domain III of EF-G.
    Proc Natl Acad Sci U S A. 2025;122:e2508779122.
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    November 2025
  16. HU L, Zhang A, Warshel A
    Exploring evolutionary trajectories of drug resistance.
    Proc Natl Acad Sci U S A. 2025;122:e2517715122.
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  17. XU JY, Yu YT, Du S, Shen LQ, et al
    Discarded cigarette butts as overlooked reservoirs and amplifiers of antibiotic resistance genes and pathogens in urban green spaces.
    Proc Natl Acad Sci U S A. 2025;122:e2525377122.
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    October 2025
  18. SHEN LQ, Lin D, Ye YQ, Liu Y, et al
    Combined pesticide pollution enhances the dissemination of the phage-encoded antibiotic resistome in the soil under nitrogen deposition.
    Proc Natl Acad Sci U S A. 2025;122:e2516722122.
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  19. YANG Y, Li Y, Becker ST, Khan A, et al
    Molecular basis of SARS-CoV-2 proofreading enzyme-mediated resistance to remdesivir.
    Proc Natl Acad Sci U S A. 2025;122:e2519755122.
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    September 2025
  20. FOUNTAIN AJ, Bohning J, McLaughlin SH, Morgan TE, et al
    Structural and functional analysis of the Mycobacterium tuberculosis MmpS5L5 efflux pump presages increased bedaquiline resistance.
    Proc Natl Acad Sci U S A. 2025;122:e2516660122.
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  21. CARD KJ, Crozier D, Durmaz A, Gray J, et al
    Evolution under vancomycin selection drives divergent collateral sensitivity patterns in Staphylococcus aureus.
    Proc Natl Acad Sci U S A. 2025;122:e2507962122.
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  22. WANG ER, Cho K, Harrison GA, Smelyansky SR, et al
    Metabolic rewiring of isoniazid sensitivity in Mycobacterium tuberculosis.
    Proc Natl Acad Sci U S A. 2025;122:e2421336122.
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    August 2025
  23. XIE T, Lin D, Cai XD, Ma LJ, et al
    Nano-biochar regulates phage-host interactions, reducing antibiotic resistance genes in vermicomposting systems.
    Proc Natl Acad Sci U S A. 2025;122:e2511986122.
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  24. LAHIRI H, Israeli E, Krugliak M, Basu K, et al
    A bacteria-based search for drugs against avian and swine flu yields a potent and resistance-resilient channel blocker.
    Proc Natl Acad Sci U S A. 2025;122:e2502240122.
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  25. BOLOURCHI N, Brown CRP, Letten AD, Engelstadter J, et al
    Evolution and evolvability of rifampicin resistance across the bacterial tree of life.
    Proc Natl Acad Sci U S A. 2025;122:e2424307122.
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    July 2025
  26. JONES BS, Pareek V, Hu DD, Weaver SD, et al
    N-acetyltransferases required for iron uptake and aminoglycoside resistance promote virulence lipid production in Mycobacterium marinum.
    Proc Natl Acad Sci U S A. 2025;122:e2502577122.
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    June 2025
  27. COLQUHOUN JM, Brzezinski CU, Ji A, Marotta J, et al
    Repurposing a drug to punish carbapenem-resistant Acinetobacter baumannii.
    Proc Natl Acad Sci U S A. 2025;122:e2423650122.
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    May 2025
  28. PEEK J, Bhattacharjee A, Burian J, Hsieh DC, et al
    Environmental resistome-guided development of resistance-tolerant antibiotics.
    Proc Natl Acad Sci U S A. 2025;122:e2504781122.
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  29. SUN W, Wang J, Wang G, Jiang L, et al
    Exposure and health risks of livestock air resistomes.
    Proc Natl Acad Sci U S A. 2025;122:e2403866122.
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    April 2025
  30. PHARKJAKSU S, Cai H, Walter PJ, Chang YC, et al
    Elevated UDP-glucuronic acid levels mend drug resistance and stress responses via a protease and a transporter in Cryptococcus gattii.
    Proc Natl Acad Sci U S A. 2025;122:e2503960122.
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  31. FOUNTAIN AJ, Waller NJE, Cheung CY, Jowsey W, et al
    Verapamil and its metabolite norverapamil inhibit the Mycobacterium tuberculosis MmpS5L5 efflux pump to increase bedaquiline activity.
    Proc Natl Acad Sci U S A. 2025;122:e2426827122.
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  32. WANG Y, Sun L, Fernandes L, Wang YH, et al
    Mechanistic insights into dengue virus inhibition by a clinical trial compound NITD-688.
    Proc Natl Acad Sci U S A. 2025;122:e2426922122.
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  33. TSE MW, Zhu M, Peters B, Hamami E, et al
    Large-scale combination screens reveal small-molecule sensitization of antibiotic-resistant gram-negative ESKAPE pathogens.
    Proc Natl Acad Sci U S A. 2025;122:e2402017122.
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    February 2025
  34. DENK-LOBNIG MK, Wood KB
    Spatial population dynamics of bacterial colonies with social antibiotic resistance.
    Proc Natl Acad Sci U S A. 2025;122:e2417065122.
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  35. MAJUMDAR S, Kashyap A, Koripella RK, Sharma MR, et al
    HflX-mediated drug resistance through ribosome splitting and rRNA disordering in mycobacteria.
    Proc Natl Acad Sci U S A. 2025;122:e2419826122.
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  36. ZHANG M, Zhao Y, Cui H, Huang W, et al
    CO(2) potentiates echinocandin efficacy during invasive candidiasis therapy via dephosphorylation of Hsp90 by Ptc2 in condensates.
    Proc Natl Acad Sci U S A. 2025;122:e2417721122.
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    December 2024
  37. MUETTER M, Angst DC, Regoes RR, Bonhoeffer S, et al
    The impact of treatment strategies on the epidemiological dynamics of plasmid-conferred antibiotic resistance.
    Proc Natl Acad Sci U S A. 2024;121:e2406818121.
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  38. DAI L, Wu Z, Sahin O, Zhao S, et al
    Mutation-based mechanism and evolution of the potent multidrug efflux pump RE-CmeABC in Campylobacter.
    Proc Natl Acad Sci U S A. 2024;121:e2415823121.
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  39. KLEIN EY, Impalli I, Poleon S, Denoel P, et al
    Global trends in antibiotic consumption during 2016-2023 and future projections through 2030.
    Proc Natl Acad Sci U S A. 2024;121:e2411919121.
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    November 2024
  40. HUANG J, Larmore CJ, Priest SJ, Xu Z, et al
    Distinct evolutionary trajectories following loss of RNA interference in Cryptococcus neoformans.
    Proc Natl Acad Sci U S A. 2024;121:e2416656121.
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  41. HORAK RD, Ciemniecki JA, Newman DK
    Bioenergetic suppression by redox-active metabolites promotes antibiotic tolerance in Pseudomonas aeruginosa.
    Proc Natl Acad Sci U S A. 2024;121:e2406555121.
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  42. BAUSSIER C, Oriol C, Durand S, Py B, et al
    Small RNA OxyS induces resistance to aminoglycosides during oxidative stress by controlling Fe-S cluster biogenesis in Escherichia coli.
    Proc Natl Acad Sci U S A. 2024;121:e2317858121.
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    October 2024
  43. RYCROFT JA, Giorgio RT, Sargen M, Helaine S, et al
    Tracking the progeny of bacterial persisters using a CRISPR-based genomic recorder.
    Proc Natl Acad Sci U S A. 2024;121:e2405983121.
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    September 2024
  44. TUFFET R, Carvalho G, Godeux AS, Mazzamurro F, et al
    Manipulation of natural transformation by AbaR-type islands promotes fixation of antibiotic resistance in Acinetobacter baumannii.
    Proc Natl Acad Sci U S A. 2024;121:e2409843121.
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  45. HATTORI SI, Bulut H, Hayashi H, Kishimoto N, et al
    Structural and virologic mechanism of the emergence of resistance to M(pro) inhibitors in SARS-CoV-2.
    Proc Natl Acad Sci U S A. 2024;121:e2404175121.
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  46. WANG Y, Gao S, Wu F, Gong Y, et al
    Cryo-EM structures of a mycobacterial ABC transporter that mediates rifampicin resistance.
    Proc Natl Acad Sci U S A. 2024;121:e2403421121.
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    July 2024
  47. BUIJS NP, Vlaming HC, Kotsogianni I, Arts M, et al
    A classic antibiotic reimagined: Rationally designed bacitracin variants exhibit potent activity against vancomycin-resistant pathogens.
    Proc Natl Acad Sci U S A. 2024;121:e2315310121.
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    June 2024
  48. BURATA OE, O'Donnell E, Hyun J, Lucero RM, et al
    Peripheral positions encode transport specificity in the small multidrug resistance exporters.
    Proc Natl Acad Sci U S A. 2024;121:e2403273121.
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  49. OGUNLADE B, Tadesse LF, Li H, Vu N, et al
    Rapid, antibiotic incubation-free determination of tuberculosis drug resistance using machine learning and Raman spectroscopy.
    Proc Natl Acad Sci U S A. 2024;121:e2315670121.
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    April 2024
  50. XU Q, Zhang H, Vandenkoornhuyse P, Guo S, et al
    Carbon starvation raises capacities in bacterial antibiotic resistance and viral auxiliary carbon metabolism in soils.
    Proc Natl Acad Sci U S A. 2024;121:e2318160121.
    >> Share

  51. WEAVER DT, King ES, Maltas J, Scott JG, et al
    Reinforcement learning informs optimal treatment strategies to limit antibiotic resistance.
    Proc Natl Acad Sci U S A. 2024;121:e2303165121.
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  52. BISWAS A, Choudhuri I, Arnold E, Lyumkis D, et al
    Kinetic coevolutionary models predict the temporal emergence of HIV-1 resistance mutations under drug selection pressure.
    Proc Natl Acad Sci U S A. 2024;121:e2316662121.
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    March 2024
  53. SCHWARTZMAN JA, Lebreton F, Salamzade R, Shea T, et al
    Global diversity of enterococci and description of 18 previously unknown species.
    Proc Natl Acad Sci U S A. 2024;121:e2310852121.
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    December 2023
  54. ALONSO-DEL VALLE A, Toribio-Celestino L, Quirant A, Pi CT, et al
    Antimicrobial resistance level and conjugation permissiveness shape plasmid distribution in clinical enterobacteria.
    Proc Natl Acad Sci U S A. 2023;120:e2314135120.
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    October 2023
  55. KOBRAS CM, Monteith W, Somerville S, Delaney JM, et al
    Loss of Pde1 function acts as an evolutionary gateway to penicillin resistance in Streptococcus pneumoniae.
    Proc Natl Acad Sci U S A. 2023;120:e2308029120.
    >> Share


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