January 2026
1. HADA M, Collet C, Storozhenko T, Munhoz D, et al
   Rationale and design of European microcirculatory resistance and absolute flow team: The Euro-CRAFT registry.
   Am Heart J. 2026;291:136-143.
   

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2. EGBE AC, Abozied O, Abdelhalim AT, Jain CC, et al
   Relationship between left atrial stiffness, pulmonary congestion, and impaired aerobic capacity in adults with repaired coarctation of aorta.
   Am Heart J. 2026;291:89-100.
   

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3. TSIGKAS G, Trigka-Vasilakopoulou A, Apostolos A, Papafaklis M, et al
   Distal versus conventional transradial artery access for coronary catheterization in patients with STEMI (DR-STEMI): Rationale and design of an international, multicenter, randomized trial.
   Am Heart J. 2026;291:73-80.
   

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   December 2025
4. MCCARTHY CP, Ballantyne CM, Blankstein R, Budoff MJ, et al
   Rationale and design of the REMBRANDT trial: A phase 3 study to evaluate the effect of obicetrapib/ezetimibe on coronary plaque characteristics.
   Am Heart J. 2025;290:325-338.
   

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5. ALSAIED T, Li R, Grant H, Schiff MD, et al
   Defining diastolic dysfunction post-Fontan: Threshold, risk factors, and associations with outcomes.
   Am Heart J. 2025;290:288-296.
   

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6. LI Y, Schiff M, Olivieri LJ, Christopher AB, et al
   The long-term effect of the Fontan fenestration on clinical outcomes: A FORCE registry study.
   Am Heart J. 2025;290:105-114.
   

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7. GALLEGOS FN, Bernstein D, Punn R, Long J, et al
   Systolic performance of the single ventricle, exercise capacity, and endothelial function in pediatric Fontan patients.
   Am Heart J. 2025;290:58-68.
   

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   November 2025
8. GURVITZ M, Roseman A, Sahakian L, Calderon J, et al
   Design and rationale of "Antecedents and correlates of well-being in young adults with congenital heart disease in the Boston Circulatory Arrest Study (BCAS-adult)".
   Am Heart J. 2025;289:127-137.
   

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9. RAVI SN, O'Shea M, Baqal O, Fatunde OA, et al
   The incremental role of late gadolinium enhancement in risk stratifying high risk patients with hypertrophic cardiomyopathy.
   Am Heart J. 2025;289:28-37.
   

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10. BRUNS B, Elsous N, Burghaus I, Steyrer K, et al
    Rationale and design of the cyclosporine in Takotsubo syndrome (CIT) trial.
    Am Heart J. 2025;289:147-157.
    

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    September 2025
11. GIOIA GD, Ferrera A, Mestrini V, Monosilio S, et al
    Myocardial Work Indexes in elite athletes: An Emerging Echocardiographic Tool to confirm physiologic cardiac remodeling in elite athletes with mildly reduced systolic function.
    Am Heart J. 2025 Sep 8:S0002-8703(25)00324-2. doi: 10.1016/j.ahj.2025.
    

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12. FEISTRITZER HJ, Jobs A, Zeymer U, Schneider S, et al
    Complete revascularization versus culprit-lesion only PCI in patients with NSTEMI and multivessel disease - Design and rationale of the randomized COMPLETE-NSTEMI trial.
    Am Heart J. 2025;287:94-106.
    

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    August 2025
13. PARK HS, Suh CH, Ahn JM, Kang DY, et al
    Effect of Cerebral Embolic Protection Device on New Cerebral Embolism During Transcatheter Aortic Valve Replacement: A Prospective Sentinel Registry.
    Am Heart J. 2025 Aug 13:S0002-8703(25)00296-0. doi: 10.1016/j.ahj.2025.
    

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14. BOERHOUT CKM, Namba HF, Liu T, Beijk MAM, et al
    Rationale and design of the ILIAS ANOCA clinical trial: A blinded-arm controlled trial for routine ad-hoc coronary function testing.
    Am Heart J. 2025;286:1-13.
    

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    July 2025
15. VAKILPOUR A, Levin MG, Anyanwu EC, Denduluri S, et al
    Referral patterns and clinical outcomes in patients with severe aortic stenosis: A multicenter cohort study.
    Am Heart J. 2025 Jul 22:S0002-8703(25)00223-6. doi: 10.1016/j.ahj.2025.
    

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16. COSTA IBSDS, Furtado RHM, Drager LF, de Barros E Silva PGM, et al
    Effects of carvedilol on the prevention of cardiotoxicity induced by anthracyclines: Design and rationale of the CARDIOTOX trial.
    Am Heart J. 2025;285:1-11.
    

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    June 2025
17. HOPPER I, Marwick TH, Wolfe R, Amerena J, et al
    STAREE-HEART: a randomized placebo-controlled trial of atorvastatin effects on a marker of cardiac aging in older individuals without prior cardiovascular disease events: Protocol and baseline description of participants.
    Am Heart J. 2025 Jun 12:S0002-8703(25)00193-0. doi: 10.1016/j.ahj.2025.
    

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18. CUTLIP DE, Mehran R, Doros G, Kaplinskiy V, et al
    Prospective randomized single-blind multicenter study to assess the safety and effectiveness of the SELUTION SLR 014 drug eluting balloon in the treatment of subjects with in-stent restenosis: Rationale and design.
    Am Heart J. 2025;284:11-19.
    

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    May 2025
19. GENG Q, Ying Z, Zhenyan M, Renqiang Y, et al
    Long-term Prognostic Role of Persistent Microvascular Obstruction Determined by Cardiac Magnetic Resonance for ST-segment Elevation Myocardial Infarction.
    Am Heart J. 2025 May 29:S0002-8703(25)00187-5. doi: 10.1016/j.ahj.2025.
    

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20. KITTIPIBUL V, Cyr DD, Harrington J, Lala A, et al
    Structural Abnormalities and Effects of Sacubitril/Valsartan in Patients with Mildly Reduced or Preserved Ejection Fraction and Worsening Heart Failure: The PARAGLIDE-HF Trial.
    Am Heart J. 2025 May 22:S0002-8703(25)00161-9. doi: 10.1016/j.ahj.2025.
    

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21. MAINI AS, Abu-Much A, Redfors B, Wollmuth JR, et al
    Outcomes Among Patients with Coronary Bifurcation Lesions Undergoing Impella-Supported High-Risk Percutaneous Coronary Intervention.
    Am Heart J. 2025 May 22:S0002-8703(25)00176-0. doi: 10.1016/j.ahj.2025.
    

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22. WHITE HD, O'Brien SM, Boden WE, Fremes SE, et al
    Use of Coronary Artery Bypass Graft Surgery and Percutaneous Coronary Intervention and Associated Outcomes in the ISCHEMIA Trial.
    Am Heart J. 2025 May 20:S0002-8703(25)00165-6. doi: 10.1016/j.ahj.2025.
    

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23. RAI B, Yildiz M, Bergstedt S, Bandari A, et al
    Diversity of Electrocardiographic Patterns in Left Main Culprit Acute ST-Elevation Myocardial Infarction.
    Am Heart J. 2025 May 14:S0002-8703(25)00164-4. doi: 10.1016/j.ahj.2025.
    

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24. JAMES S, Christoffersen AD, David JP, Hacker M, et al
    Effect of Once-Weekly Subcutaneous Semaglutide on Arterial Inflammation in People with Type 2 Diabetes and Cardiovascular Disease Using PET-MRI: Primary Results of a Randomized, Double-Blind, Placebo-Controlled Trial.
    Am Heart J. 2025 May 7:S0002-8703(25)00156-5. doi: 10.1016/j.ahj.2025.
    

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25. BALTER S, Moses J, Hyasat K, Collins M, et al
    Evolving operator practices reduced patient radiation dose in interventional cardiology: Trends in a single center.
    Am Heart J. 2025;283:5-16.
    

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    April 2025
26. BOCKUS L, Kassar A, Chahine Y, Chamoun N, et al
    Atrial fibrillation is associated with higher oxygen extraction in the human heart.
    Am Heart J. 2025 Apr 15:S0002-8703(25)00129-2. doi: 10.1016/j.ahj.2025.
    

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27. SOMSEN YBO, de Winter RW, Wu J, Hoek R, et al
    Design and rationale of the drug-coated balloon coronary angioplasty versus stenting for treatment of disease adjacent to a chronic total occlusion (Co-CTO) trial.
    Am Heart J. 2025 Apr 7:S0002-8703(25)00105-X. doi: 10.1016/j.ahj.2025.
    

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28. ANAND SC, Narowska G, Gangireddy C, Enevoldsen J, et al
    Novel automated electronic medical record-based VEST (virtual echocardiography screening tool) algorithm for pulmonary arterial hypertension.
    Am Heart J. 2025 Apr 5:S0002-8703(25)00102-4. doi: 10.1016/j.ahj.2025.
    

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29. COSSETTE F, Trifan A, Prevost-Marcotte G, Doolub G, et al
    Tailored hydration for the prevention of contrast-induced acute kidney injury after coronary angiogram or PCI: A systematic review and meta-analysis.
    Am Heart J. 2025;282:93-102.
    

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    March 2025
30. NOORY N, Westin O, Borgersen EH, Kragelund C, et al
    Absence of Coronary Artery Disease in Patients Undergoing Coronary Imaging and Association with Amyloidosis - A Danish Nationwide Study.
    Am Heart J. 2025 Mar 26:S0002-8703(25)00093-6. doi: 10.1016/j.ahj.2025.
    

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31. ONUMA Y, Ninomiya K, Sjauw K, Damman P, et al
    Accuracy of Instantaneous Wave-free Ratio and Fractional Flow Reserve Derived From Single Coronary Angiographic Projections.
    Am Heart J. 2025 Mar 11:S0002-8703(25)00071-7. doi: 10.1016/j.ahj.2025.
    

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32. DONAZZAN L, Bulian F, Maines M, Erckert M, et al
    Effect of rate-adaptive atrial support compared to VDD pacing in cardiac resynchronization therapy recipients: A randomized cross-over study.
    Am Heart J. 2025;281:149-156.
    

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33. TRUONG DT, Harty BJ, Bainton J, Baker A, et al
    Design and rationale of the COVID vaccine-associated myocarditis/pericarditis (CAMP) study.
    Am Heart J. 2025;281:32-42.
    

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    February 2025
34. TAKAHASHI T, Wei J, Iribarren AC, Gulati M, et al
    Rationale and design of the Women's Ischemia Syndrome Evaluation Mechanisms of Coronary Microvascular Dysfunction Leading to Pre-Heart Failure With Preserved Ejection Fraction (WISE Pre-HFpEF).
    Am Heart J. 2025 Feb 24:S0002-8703(25)00056-0. doi: 10.1016/j.ahj.2025.
    

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35. CHATUR S, Seth M, Casey M, Thompson M, et al
    Reminders EMbedded IN PCI Reports to Optimize Discharge Diabetes Mellitus Care (REMIND-DM): Rationale, Design, and Baseline Characteristics.
    Am Heart J. 2025 Feb 21:S0002-8703(25)00019-5. doi: 10.1016/j.ahj.2025.
    

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36. ERRIQUEZ A, Colaiori I, Hakeem A, Guiducci V, et al
    Functional Coronary Angiography to Indicate and Guide Revascularization in STEMI Patients with Multivessel Disease: Rationale and Design of the AIR-STEMI trial: Functional coronary angiography in STEMI patients.
    Am Heart J. 2025 Feb 19:S0002-8703(25)00042-0. doi: 10.1016/j.ahj.2025.
    

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37. PASQUALIN G, Misra A, Gauvreau K, Sanders SP, et al
    Ventricular-Arterial Coupling is associated with Clinical Outcomes in Patients with Systemic Right Ventricle.
    Am Heart J. 2025 Feb 19:S0002-8703(25)00043-2. doi: 10.1016/j.ahj.2025.
    

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38. BAINEY KR, Welsh RC, Zheng Y, Arias-Mendoza A, et al
    Pharmaco-invasive Strategy and Dosing of Tenecteplase in STEMI Patients 60 to <75 Years: An Inter-trial Comparison of the STREAM-1 and STREAM-2 Trials: Comparison of Patients 60 to <75 Years in STREAM-1 and -2.
    Am Heart J. 2025 Feb 12:S0002-8703(25)00032-8. doi: 10.1016/j.ahj.2025.
    

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39. GAO XF, Kan J, Wu HY, Chen J, et al
    Intravascular Imaging-guided versus Angiography-guided Percutaneous Coronary Intervention in Patients with Diabetes Mellitus: Rationale and design of an International, Multicenter, Randomized IVI-DIABETES Trial.
    Am Heart J. 2025 Feb 4:S0002-8703(25)00017-1. doi: 10.1016/j.ahj.2025.
    

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40. WANG G, Zhang R, Chen SL, Wang J, et al
    Targeted Therapy with a Localized abluminal Groove Low-Dose Sirolimus-Eluting Bioabsorbable Polymer Coronary Stent in Chronic Total Occlusions: The TARGET CTO Non-Inferiority Randomized Trial.
    Am Heart J. 2025 Feb 3:S0002-8703(25)00018-3. doi: 10.1016/j.ahj.2025.
    

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    January 2025
41. STEG PG, Nicolas J, Baber U, Sartori S, et al
    Characterizing High-Risk Enrollment Criteria and Impact on Clinical Outcomes in a Large Randomized Clinical Trial: Insights From the TWILIGHT Trial.
    Am Heart J. 2025 Jan 29:S0002-8703(25)00016-X. doi: 10.1016/j.ahj.2025.
    

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42. POLOMSKI EAS, Heemelaar JC, de Ronde MES, Al Jaff AAM, et al
    Increased Prevalence of Coronary Atherosclerosis in Cancer Survivors: A Retrospective Matched Cross-sectional Study with Coronary CT Angiography.
    Am Heart J. 2025 Jan 8:S0002-8703(25)00004-3. doi: 10.1016/j.ahj.2025.
    

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43. SHECHTER A, Gupta A, Kaewkes D, Taheri H, et al
    Implications of an Off-Hours Setting in Patients Undergoing Transcatheter Edge-to-Edge Repair for Mitral Regurgitation.
    Am Heart J. 2025 Jan 2:S0002-8703(24)00341-7. doi: 10.1016/j.ahj.2024.
    

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    December 2024
44. TRISTAO-PEREIRA C, Fuster V, Lopez-Jimenez A, Fernandez-Pena A, et al
    Subclinical atherosclerosis and brain health in midlife: Rationale and design of the PESA-Brain study.
    Am Heart J. 2024;278:195-207.
    

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    November 2024
45. ABRAMOWITZ SD, Marko X, D'Souza D, Noor S, et al
    Rationale and Design of the DEFIANCE Study: A Randomized Controlled Trial of Mechanical Thrombectomy Versus Anticoagulation Alone for Iliofemoral Deep Vein Thrombosis.
    Am Heart J. 2024 Nov 2:S0002-8703(24)00278-3. doi: 10.1016/j.ahj.2024.
    

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    October 2024
46. BARONE-ROCHETTE G, Vanzetto G, Danchin N, Steg PG, et al
    Rationale and design of the multicentric randomized EVAOLD trial: evaluation of a strategy guided by imaging versus routine invasive strategy in elderly patients with ischemia.
    Am Heart J. 2024 Oct 22:S0002-8703(24)00274-6. doi: 10.1016/j.ahj.2024.
    

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47. THURAIAIYAH J, Jorgensen TH, Jensen JM, Fuchs A, et al
    Prospective study on the impact of different anti-thrombotic therapies on subclinical leaflet thickening and its temporal dynamics in transcatheter aortic valves - The NOTION-4 trial: Anti-thrombotic therapy and TAV-HALT.
    Am Heart J. 2024 Oct 5:S0002-8703(24)00264-3. doi: 10.1016/j.ahj.2024.
    

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    September 2024
48. NELSON MD, Gomez-Arnold JM, Wei J, Lauzon M, et al
    Contributors to high left ventricular ejection fraction in women with ischemia and no obstructive coronary artery disease: Results from the Women's Ischemia Syndrome Evaluation - Coronary Vascular Dysfunction (WISE-CVD) Study.
    Am Heart J. 2024 Sep 2:S0002-8703(24)00224-2. doi: 10.1016/j.ahj.2024.
    

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49. LINDLEY KJ, Barker C, Mahmoud Z, Raghuraman N, et al
    Decreased postpartum exercise capacity after a diagnosis of pre-eclampsia: Implications for CVD risk prediction.
    Am Heart J. 2024;275:192-199.
    

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50. RWEBEMBERA J, Ndagire E, Carvalho N, Webel AR, et al
    Intramuscular versus enteral penicillin prophylaxis to prevent progression of rheumatic heart disease: Study protocol for a noninferiority randomized trial (the GOALIE trial).
    Am Heart J. 2024;275:74-85.
    

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    August 2024
51. SOH CH, Wright L, Baumann A, Seidel B, et al
    Use of artificial intelligence-guided echocardiography to detect cardiac dysfunction and heart valve disease in rural and remote areas: Rationale and design of the AGILE-echo trial.
    Am Heart J. 2024;277:11-19.
    

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52. STAHLI BE, Linke A, Westermann D, Van Mieghem NM, et al
    A Randomized Comparison of the Treatment Sequence of Percutaneous Coronary Intervention and Transcatheter Aortic Valve Implantation: Rationale and Design of the TAVI PCI Trial.
    Am Heart J. 2024 Aug 7:S0002-8703(24)00184-4. doi: 10.1016/j.ahj.2024.
    

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53. DUARTE VE, Yamamura K, Economy KE, Graf JA, et al
    The effects of pregnancy in subjects with repaired tetralogy of Fallot.
    Am Heart J. 2024;274:95-101.
    

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    July 2024
54. BURGOS LM, Vila RCB, Ballari FN, Goyeneche A, et al
    Inferior vena CAVA and Lung UltraSound-guided therapy in Acute Heart Failure: a randomized pilot study (CAVAL US-AHF study).
    Am Heart J. 2024 Jul 31:S0002-8703(24)00181-9. doi: 10.1016/j.ahj.2024.
    

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55. ERBAY A, Penzel L, Abdelwahed YS, Heuberger A, et al
    Prognostic impact of quantitative flow ratio (QFR)-consistent complete revascularization in patients with myocardial infarction and multivessel coronary artery disease.
    Am Heart J. 2024 Jul 19:S0002-8703(24)00177-7. doi: 10.1016/j.ahj.2024.
    

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56. POLSINELLI VB, Koczo A, Johnson AE, Elkayam U, et al
    Race, Hypertensive Disorders of Pregnancy and Outcomes in Peripartum Cardiomyopathy.
    Am Heart J. 2024 Jul 10:S0002-8703(24)00168-6. doi: 10.1016/j.ahj.2024.
    

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    June 2024
57. ABOU-KARAM R, Tanguturi V, Cheng F, Elmariah S, et al
    Trial Designs A44002PZS Electronic Physician Notification to Facilitate the Recognition and Management of Severe Aortic Stenosis: Rationale, design, and methods of the randomized controlled DETECT AS Trial.
    Am Heart J. 2024 Jun 29:S0002-8703(24)00163-7. doi: 10.1016/j.ahj.2024.
    

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58. JEYAPRAKASH P, Pathan F, Ozawa K, Robledo KP, et al
    Restoring microvascular circulation with diagnostic ultrasound and contrast agent: Rationale and Design of the REDUCE trial.
    Am Heart J. 2024 Jun 27:S0002-8703(24)00162-5. doi: 10.1016/j.ahj.2024.
    

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59. BRUNO F, Rampone JM, Islas F, Gorla R, et al
    Echocardiographic and clinical features of patients developing prosthesis-patient mismatch after TAVR: insights from the Recovery TAVR registry.
    Am Heart J. 2024 Jun 3:S0002-8703(24)00137-6. doi: 10.1016/j.ahj.2024.
    

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60. SONG L, Guan C, Yu M, Sun Z, et al
    Sirolimus-eluting iron bioresorbable scaffold versus cobalt-chromium everolimus-eluting stents in patients with coronary artery disease: rationale and design of the IRONMAN-II trial.
    Am Heart J. 2024 Jun 3:S0002-8703(24)00140-6. doi: 10.1016/j.ahj.2024.
    

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    May 2024
61. KIM Y, Park H, Yoon HJ, Suh J, et al
    Fully Automated Quantitative Coronary Angiography Versus Optical Coherence Tomography Guidance for Coronary Stent Implantation (FLASH): Study Protocol for a Randomized Controlled Non-Inferiority Trial.
    Am Heart J. 2024 May 7:S0002-8703(24)00119-4. doi: 10.1016/j.ahj.2024.
    

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    April 2024
62. KIM MC, Ahn JH, Hyun DY, Lim Y, et al
    Timing of fractional flow reserve-guided complete revascularization in patients with ST-segment elevation myocardial infarction with multivessel disease: Rationale and design of the OPTION-STEMI trial.
    Am Heart J. 2024 Apr 17:S0002-8703(24)00078-4. doi: 10.1016/j.ahj.2024.
    

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63. ETIWY M, Flannery LD, Li SX, Morrison FJ, et al
    Examining Lack of Referrals to Heart Valve Specialists as Mechanisms of Potential Underutilization of Aortic Valve Replacement.
    Am Heart J. 2024 Apr 13:S0002-8703(24)00093-0. doi: 10.1016/j.ahj.2024.
    

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    March 2024
64. MILLER HE, Tierney S, Stefanick ML, Mayo JA, et al
    Vascular health years after a hypertensive disorder of pregnancy: The EPOCH Study.
    Am Heart J. 2024 Mar 12:S0002-8703(24)00055-3. doi: 10.1016/j.ahj.2024.
    

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    February 2024
65. MEHDIPOOR G, Redfors B, Chen S, Gkargkoulas F, et al
    Hypertension, Microvascular Obstruction and Infarct Size in Patients with STEMI Undergoing PCI: Pooled Analysis from 7 Cardiac Magnetic Resonance Imaging Studies.
    Am Heart J. 2024 Feb 29:S0002-8703(24)00050-4. doi: 10.1016/j.ahj.2024.
    

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66. DEHGHANI P, Singh J, Mancini GBJ, Stanberry L, et al
    Angiographic characteristics of Patients with STEMI and COVID-19 - Insights from NACMI Registry.
    Am Heart J. 2024 Feb 21:S0002-8703(24)00039-5. doi: 10.1016/j.ahj.2024.
    

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    January 2024
67. CEVIK E, Tas A, Demirtakan ZG, Damman P, et al
    Intracoronary Electrocardiogram Detects Coronary Microvascular Dysfunction and Ischemia in Patients with No Obstructive Coronary Arteries Disease.
    Am Heart J. 2024 Jan 24:S0002-8703(24)00010-3. doi: 10.1016/j.ahj.2024.
    

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    November 2023
68. MUNHOZ D, Collet C, Mizukami T, Yong A, et al
    Rationale and design of the pullback pressure gradient (PPG) global registry.
    Am Heart J. 2023;265:170-179.
    

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