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Articles published in
Metabolism
    September 2026
  1. FAN Y, Chen X, Cai X, Dong Y, et al
    SGLT2 inhibitors and GLP-1 receptor agonists in atrial fibrillation treatment: Clinical evidence and mechanistic insights.
    Metabolism. 2026;182:156678.
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  2. AI W, Pan Q, Shen Z, Yang W, et al
    Hepatic TGFbeta1 signaling impairs insulin sensitivity via inducing insulin receptor substrate 1 degradation.
    Metabolism. 2026;182:156654.
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    July 2026
  3. YANG L, Wang Y, Wang D, Zhang L, et al
    Reduction of PDZK1 promotes diabetic kidney disease by modulating fatty acid uptake in proximal tubular epithelial cells.
    Metabolism. 2026 Jul 31:156720. doi: 10.1016/j.metabol.2026.156720.
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  4. CHEN Y, Zhang Y, Yu F, Ni Y, et al
    From metabolic subtypes to preventive decisions in high-risk type 2 diabetes.
    Metabolism. 2026 Jul 30:156718. doi: 10.1016/j.metabol.2026.156718.
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  5. DENG K, Li-Gao R
    Reply to letter to the editor: From metabolic subtypes to preventive decisions in high-risk type 2 diabetes.
    Metabolism. 2026 Jul 29:156719. doi: 10.1016/j.metabol.2026.156719.
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  6. WU SD, Wang X, Zhou YM, Hu B, et al
    Setmelanotide alleviates diabetes-associated cognitive impairment by interrupting the binding of ICAM-1 and JIP1 in endothelial cells of the blood-brain barrier.
    Metabolism. 2026 Jul 24:156712. doi: 10.1016/j.metabol.2026.156712.
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  7. DI GIUSEPPE G, Gliozzo G, Carciero L, Puzzangara MC, et al
    Differential mirroring between in vivo insulin secretion and ex vivo islet function in individuals with and without diabetes.
    Metabolism. 2026 Jul 24:156715. doi: 10.1016/j.metabol.2026.156715.
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  8. DENG K, Hameete A, Schrauwen P, Wagner R, et al
    Pathophysiology-based subtypes of individuals at high-risk of type 2 diabetes: multi-omics profiles and lifestyle differences across subtypes.
    Metabolism. 2026 Jul 1:156687. doi: 10.1016/j.metabol.2026.156687.
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    June 2026
  9. FERRARI D, Bonaventura I, Tenuta M, Pofi R, et al
    Rethinking hypercortisolism screening in obesity and diabetes: A systematic review and meta-analysis.
    Metabolism. 2026 Jun 14:156675. doi: 10.1016/j.metabol.2026.156675.
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  10. TRYBULSKI R, Zebrowska A, Fostiak K, Olaniszyn G, et al
    Resistance training and diabetes mellitus type 2: An umbrella review of systematic reviews and meta-analyses on glycemic and cardiometabolic outcomes.
    Metabolism. 2026;182:156671.
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  11. BAILEY CJ, Gwilt M, Brand KMG
    Metformin: Antidiabetic actions from cells to tissues.
    Metabolism. 2026;179:156589.
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  12. ZHANG H, Chen QF, Lip GYH, Tilg H, et al
    Burden of metabolic diseases, 1990-2023, with forecasts to 2030 for the Asia-Pacific region.
    Metabolism. 2026;179:156575.
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    May 2026
  13. ZHANG H, Yue T, Wang S, Shi J, et al
    A multi-omics atlas of multisystem complications in type 2 diabetes reveals molecular signatures and improves risk prediction.
    Metabolism. 2026 May 20:156650. doi: 10.1016/j.metabol.2026.156650.
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  14. GARCIA-GAVILAN JF, Paz-Graniel I, Salas-Salvado J
    Reply to letter to the editor: Metabolomic signatures of type 2 diabetes and mortality: Methodological considerations and unresolved questions.
    Metabolism. 2026 May 18:156649. doi: 10.1016/j.metabol.2026.156649.
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  15. LIU J, Xu W, Yan W, Qin Y, et al
    Islet inflammatory macrophages drive MSC loss and multiple interactions involved in beta-cell adaptation during diabetes.
    Metabolism. 2026;181:156636.
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  16. YAMAZAKI H, Tokgoz S, Tauchi S, Nakamura F, et al
    Structural determinants of beta-cell failure in type 2 diabetes: a multimodality imaging study.
    Metabolism. 2026 May 13:156631. doi: 10.1016/j.metabol.2026.156631.
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  17. HAN J
    Metabolomic signatures of type 2 diabetes and mortality: Methodological considerations and unresolved questions.
    Metabolism. 2026 May 7:156627. doi: 10.1016/j.metabol.2026.156627.
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  18. GIOSUE A, Skantze V, Testa R, D'Abbronzo G, et al
    Postprandial glucose profiles may reflect heterogeneity in insulin secretion and sensitivity in type 2 diabetes.
    Metabolism. 2026;181:156626.
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  19. ATABAKI NN, Coral DE, Pomares-Millan H, Smith K, et al
    A biological-systems-based analysis using proteomic and metabolic network inference reveals mechanistic insights into hepatic steatosis.
    Metabolism. 2026;178:156552.
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    April 2026
  20. JIANG M, An X
    6-Phosphofructokinase-2/fructose-2,6-bisphosphatase 3: A potential target in the development of diabetes and its complications.
    Metabolism. 2026 Apr 14:156621. doi: 10.1016/j.metabol.2026.156621.
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  21. MUZUROVIC E, Katsiki N, Volcansek S, Plescia F, et al
    Emerging incretin- and multi-agonist-based treatments - the continued refinement and continuous expansion of a potent therapeutic armamentarium for cardio-kidney-liver-metabolic diseases and beyond.
    Metabolism. 2026;177:156494.
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  22. PANUNZI S, Russo S, Pompa M, De Gaetano A, et al
    Personalizing bariatric metabolic surgery: Predictors of weight-loss success and risk of weight recurrence.
    Metabolism. 2026;177:156495.
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    March 2026
  23. SONG W, Nie X, Zhu Z, Wang Q, et al
    Proteomics and metabolomics biomarkers for predicting the onset and progression of diabetic complications: A systematic review and bioinformatics integration.
    Metabolism. 2026 Mar 25:156601. doi: 10.1016/j.metabol.2026.156601.
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  24. GARCIA-GAVILAN JF, Paz-Graniel I, Perez-Acosta JA, Ruiz-Canela M, et al
    Metabolomics profiles of type 2 diabetes and insulin resistance and their associations with total mortality. T2D metabolites linked to mortality.
    Metabolism. 2026 Mar 23:156599. doi: 10.1016/j.metabol.2026.156599.
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  25. CHEN L, Dong X, Zhang Q, Wang H, et al
    Once-weekly insulin GZR4 versus once-daily insulin degludec in Chinese people with type 2 diabetes: A multicenter, open-label, randomized, phase 2 trial.
    Metabolism. 2026;179:156592.
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  26. KHADIVI Y, Tavallaeinejad P, Hashemipour M, Khachikian A, et al
    Mapping circulating microRNA signatures in type 1 diabetic microvascular disease: A systematic review and Bayesian multilevel meta-analysis with bioinformatic integration of molecular dysregulation.
    Metabolism. 2026 Mar 13:156591. doi: 10.1016/j.metabol.2026.156591.
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  27. GIUSTINA A, di Filippo L, Aleksova A, Bollerslev J, et al
    Consensus statement on vitamin D role in metabolic health.
    Metabolism. 2026;176:156484.
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    February 2026
  28. LEE DY, Lee JB, Jung I, Park SY, et al
    Association of daytime circadian-aligned activity with glycemic control in type 2 diabetes: Insights from continuous glucose monitoring and wearable data.
    Metabolism. 2026;179:156570.
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  29. AMREIN K, Kim SH, Brath H, Fasching P, et al
    Mini-review. Vitamin D for the prevention of type 2 diabetes: Evidence and implications.
    Metabolism. 2026 Feb 16:156566. doi: 10.1016/j.metabol.2026.156566.
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  30. LIU P, Shen N, Zhou Y, Wu J, et al
    PFKFB3 nuclear translocation improves diabetic retinopathy by attenuating endothelial cell senescence through inhibition of USP7-p53 axis.
    Metabolism. 2026;178:156553.
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  31. ZHU R, Guo J, Huttunen-Lenz M, Stratton G, et al
    Enduring improvements in hepatic insulin sensitivity predict sustained remission of prediabetes during a 3-year lifestyle intervention: results from the PREVIEW multinational diabetes prevention trial.
    Metabolism. 2026;178:156546.
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  32. ZHANG J, Guan X, Kong M, Xia M, et al
    GLP-1RAs and tirzepatide may reduce heart failure risk in obese but not in non-obese patients with cardiovascular or renal disease: A systematic review and meta-analysis.
    Metabolism. 2026;175:156433.
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    January 2026
  33. LIN Z, Lv D, Zha H, Liu H, et al
    HMGCS2 desuccinylation modulates acetoacetate to drive tubule-macrophage inflammatory crosstalk in diabetic kidney disease.
    Metabolism. 2026;177:156510.
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  34. LEANZA G, Faraj M, Cannata F, Viola V, et al
    Bone inflammation in postmenopausal women with type 2 diabetes or obesity in relation to Wnt signaling and bone strength.
    Metabolism. 2026 Jan 8:156492. doi: 10.1016/j.metabol.2026.156492.
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  35. GERLACH PA, Gadgaard S, Madsen JS, Lindquist P, et al
    Global glucagon-like peptide-2 receptor activation linked to increased obesity risk in the UK Biobank.
    Metabolism. 2026 Jan 8:156489. doi: 10.1016/j.metabol.2025.156489.
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  36. MUNOZ F, Gao Q, Mattanovich M, Trost K, et al
    Lysine potentiates insulin secretion via AASS-dependent catabolism and regulation of GABA content and signaling.
    Metabolism. 2026;174:156423.
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    December 2025
  37. D'ADDIO F, Bucciarelli L, Lunati ME, Fiorina P, et al
    Metabolic and immune dysfunction at the crossroads between type 1 diabetes and neurodegeneration.
    Metabolism. 2025 Dec 17:156471. doi: 10.1016/j.metabol.2025.156471.
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  38. YANG J, Yang X, Zheng Y, Wang A, et al
    27-Hydroxycholesterol exacerbates hepatic insulin resistance via plasma membrane cholesterol remodeling.
    Metabolism. 2025;173:156392.
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    November 2025
  39. JINYI L, Xianguang D, Yuhan D, Haoyue H, et al
    Metabolic reprogramming in diabetic foot ulcers: mechanisms, therapeutic implications and future perspectives.
    Metabolism. 2025;175:156455.
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  40. WANG Y, Sandforth A, von Schwartzenberg RJ, Ganslmeier M, et al
    Lifestyle intervention is more effective in high 1-hour post-load glucose than in prediabetes for restoring beta-cell function, reducing ectopic fat, and preventing type 2 diabetes.
    Metabolism. 2025 Nov 3:156430. doi: 10.1016/j.metabol.2025.156430.
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  41. STUBBENDORFF A, Janzi S, Jukkola J, Morency M, et al
    Mini-review of the EAT-Lancet planetary health diet and its role in cardiometabolic disease prevention.
    Metabolism. 2025;172:156373.
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    October 2025
  42. PAN L, He Y, Xiang Y, Mao B, et al
    Angiopoietin-like protein 8 mediates inflammation and fibrosis of tubular cells in diabetic kidney disease progression by interacting with Akt2.
    Metabolism. 2025 Oct 17:156418. doi: 10.1016/j.metabol.2025.156418.
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  43. ASHLAW EF, Elfers CT, Chichura KS, Miranda IC, et al
    A melanocortin 4- and glucagon-like peptide 1 receptor multiple agonist for the treatment of diabetes and obesity.
    Metabolism. 2025 Oct 13:156414. doi: 10.1016/j.metabol.2025.156414.
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  44. MISHRA RC, Mallat RK, John CM, Belke D, et al
    Administration of the K(Ca) channel activator SKA-31 improves long-term endothelial function, blood pressure regulation and cardiac performance in rats with type 2 diabetes.
    Metabolism. 2025 Oct 1:156410. doi: 10.1016/j.metabol.2025.156410.
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    August 2025
  45. HENDLINGER M, Mastrototaro L, Exterkate M, Apostolopoulou M, et al
    Exercise training increases skeletal muscle sphingomyelinases and affects mitochondrial quality control in men with type 2 diabetes.
    Metabolism. 2025 Aug 2:156361. doi: 10.1016/j.metabol.2025.156361.
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  46. HAKIM JP, Handelsman Y, Banerjee T
    Use of finerenone in patients with chronic kidney disease at high risk of heart failure.
    Metabolism. 2025;169:156297.
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  47. HUANG H, Ruan H, Lu X, Chen S, et al
    Comprehensive assessment of the causal effects and metabolite mediators of glucose-lowering drug targets on cardio-renal-liver-metabolic health.
    Metabolism. 2025;169:156276.
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    July 2025
  48. LIANG T, Jiang T, Liang Z, Chen Y, et al
    Lactiplantibacillus plantarum strain 84-3-derived l-glutamine ameliorates glucose homeostasis via AMPK/PPARgamma signaling pathway activation in type 2 diabetes.
    Metabolism. 2025;172:156357.
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  49. ZHANG H, Wang W, Liu P, Zhang T, et al
    Flot2 protects against podocyte injury by maintaining the stability of synaptopodin in diabetic nephropathy.
    Metabolism. 2025;171:156354.
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  50. GUO C, Li J, Yang X, Xie W, et al
    AEBP1 as a promising therapeutic target for skeletal muscle insulin resistance in type 2 diabetes mellitus: Convergent evidence from Mendelian randomization and functional validation.
    Metabolism. 2025 Jul 4:156339. doi: 10.1016/j.metabol.2025.156339.
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    June 2025
  51. SU JB, Chen G, Sun QY, Fu X, et al
    USP48 protects against myocardial ischemia-reperfusion injury by stabilizing and upregulating CNN1 in type 1 diabetes mice.
    Metabolism. 2025;170:156326.
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    May 2025
  52. GALAN A, Garcia-Garcia F
    Revisiting gender differences in obesity and type 2 diabetes: Response letter.
    Metabolism. 2025 May 29:156307. doi: 10.1016/j.metabol.2025.156307.
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  53. WANG P, Zhang Y, Giovannucci EL
    Dietary context in the association between red meat consumption and risk of type 2 diabetes.
    Metabolism. 2025;169:156277.
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    April 2025
  54. WU H, Yang Z, Zhou T, Wang J, et al
    UBC9 ameliorates diabetic cardiomyopathy by modulating cardiomyocyte mitophagy through NEDD4/RUNX2/PSEN2 axis.
    Metabolism. 2025 Apr 8:156264. doi: 10.1016/j.metabol.2025.156264.
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  55. ZHONG Y, Wei J, Jiang R
    Revisiting gender differences in obesity and type 2 diabetes: Letter to the editor.
    Metabolism. 2025 Apr 3:156260. doi: 10.1016/j.metabol.2025.156260.
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    March 2025
  56. MOLDOVAN RA, Hidalgo MR, Castane H, Jimenez-Franco A, et al
    Landscape of sex differences in obesity and type 2 diabetes in subcutaneous adipose tissue: a systematic review and meta-analysis of transcriptomics studies.
    Metabolism. 2025 Mar 27:156241. doi: 10.1016/j.metabol.2025.156241.
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  57. BHOWMICK DC, Ahn M, Bhattacharya S, Aslamy A, et al
    DOC2b enrichment mitigates proinflammatory cytokine-induced CXCL10 expression by attenuating IKKbeta and STAT-1 signaling in human islets.
    Metabolism. 2025;164:156132.
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  58. KARAKASIS P, Patoulias D, Fragakis N, Mantzoros CS, et al
    Effect of glucagon-like peptide-1 receptor agonists and co-agonists on body composition: Systematic review and network meta-analysis.
    Metabolism. 2025;164:156113.
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    February 2025
  59. SCHORK A, Fritsche A, Schleicher ED, Peter A, et al
    Differential risk assessment in persons at risk of type 2 diabetes using urinary peptidomics.
    Metabolism. 2025;167:156174.
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  60. HUANG J
    A systematic review & updated meta-analysis on the association between higher consumption of ultra processed foods and risk of diabetes and its complications: Letter to the editor.
    Metabolism. 2025 Feb 11:156156. doi: 10.1016/j.metabol.2025.156156.
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  61. SOUZA M, Moura FS, Lima LCV, Amaral MJM, et al
    A systematic review & updated meta-analysis on the association between higher consumption of ultra processed foods and risk of diabetes and its complications: Response letter.
    Metabolism. 2025 Feb 11:156155. doi: 10.1016/j.metabol.2025.156155.
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  62. CHEN J, Luo M, Xing Z, Chen Y, et al
    Start small, think big: MicroRNAs in diabetes mellitus and relevant cardiorenal-liver metabolic health spectrum.
    Metabolism. 2025 Feb 4:156153. doi: 10.1016/j.metabol.2025.156153.
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  63. MEZZA T, Wewer Albrechtsen NJ, Di Giuseppe G, Ferraro PM, et al
    Human subjects with impaired beta-cell function and glucose tolerance have higher levels of intra-islet intact GLP-1.
    Metabolism. 2025;163:156087.
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  64. KOKKORAKIS M, Folkertsma P, Forte JC, Wolffenbuttel BHR, et al
    GDF-15 improves the predictive capacity of steatotic liver disease non-invasive tests for incident morbidity and mortality risk for cardio-renal-metabolic diseases and malignancies.
    Metabolism. 2025;163:156047.
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    January 2025
  65. SOUZA M, Moura FS, Lima LCV, Amaral MJM, et al
    Association between higher consumption of ultra-processed foods and risk of diabetes and its complications: A systematic review & updated meta-analysis.
    Metabolism. 2025 Jan 21:156134. doi: 10.1016/j.metabol.2025.156134.
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  66. LUO YY, Ruan CS, Zhao FZ, Yang M, et al
    ZBED3 exacerbates hyperglycemia by promoting hepatic gluconeogenesis through CREB signaling.
    Metabolism. 2025;162:156049.
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  67. DENG X, Tang C, Fang T, Li T, et al
    Disruption of branched-chain amino acid homeostasis promotes the progression of DKD via enhancing inflammation and fibrosis-associated epithelial-mesenchymal transition.
    Metabolism. 2025;162:156037.
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    December 2024
  68. DOU C, Liu D, Kong L, Chen M, et al
    Shared genetic architecture of type 2 diabetes with muscle mass and function and frailty reveals comorbidity etiology and pleiotropic druggable targets.
    Metabolism. 2024 Dec 20:156112. doi: 10.1016/j.metabol.2024.156112.
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  69. KIM JS, Jun JH, Lee J, Park S, et al
    HDAC6 mediates NLRP3 inflammasome activation in the pathogenesis of diabetic retinopathy.
    Metabolism. 2024 Dec 15:156108. doi: 10.1016/j.metabol.2024.156108.
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    November 2024
  70. WU Q, Zeng Y, Geng K, Guo M, et al
    The role of IL-1 family cytokines in diabetic cardiomyopathy.
    Metabolism. 2024 Nov 25:156083. doi: 10.1016/j.metabol.2024.156083.
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  71. CONGUR I, Mingrone G, Guan K
    Targeting endoplasmic reticulum stress as a potential therapeutic strategy for diabetic cardiomyopathy.
    Metabolism. 2024 Nov 6:156062. doi: 10.1016/j.metabol.2024.156062.
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  72. ZHANG H, Zhou XD, Shapiro MD, Lip GYH, et al
    Global burden of metabolic diseases, 1990-2021.
    Metabolism. 2024;160:155999.
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    August 2024
  73. MISHRA RC, Belke DD, Singh L, Wulff H, et al
    Targeting endothelial K(Ca) channels in vivo restores arterial and endothelial function in type 2 diabetic rats.
    Metabolism. 2024 Aug 18:156001. doi: 10.1016/j.metabol.2024.156001.
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  74. ROSELL-DIAZ M, Petit-Gay A, Molas-Prat C, Gallardo-Nuell L, et al
    Metformin-induced changes in the gut microbiome and plasma metabolome are associated with cognition in men.
    Metabolism. 2024;157:155941.
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  75. CAI Z, Yang Y, Zhong J, Ji Y, et al
    cGAS suppresses beta-cell proliferation by a STING-independent but CEBPbeta-dependent mechanism.
    Metabolism. 2024;157:155933.
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    July 2024
  76. KANG JS, Cho NJ, Lee SW, Lee JG, et al
    RIPK3 causes mitochondrial dysfunction and albuminuria in diabetic podocytopathy through PGAM5-Drp1 signaling.
    Metabolism. 2024 Jul 30:155982. doi: 10.1016/j.metabol.2024.155982.
    >> Share

  77. SHU S, Cui H, Liu Z, Zhang H, et al
    Suppression of RCAN1 alleviated lipid accumulation and mitochondrial fission in diabetic cardiomyopathy.
    Metabolism. 2024 Jul 23:155977. doi: 10.1016/j.metabol.2024.155977.
    >> Share

  78. ZHAO M, Shen Z, Zheng Z, Xu Y, et al
    Cardiomyocyte LGR6 alleviates ferroptosis in diabetic cardiomyopathy via regulating mitochondrial biogenesis.
    Metabolism. 2024 Jul 20:155979. doi: 10.1016/j.metabol.2024.155979.
    >> Share

  79. RICHTER MM, Kemp IM, Heeboll S, Winther-Sorensen M, et al
    Glucagon augments the secretion of FGF21 and GDF15 in MASLD by indirect mechanisms.
    Metabolism. 2024;156:155915.
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    June 2024
  80. HANDELSMAN Y, Anderson JE, Bakris GL, Ballantyne CM, et al
    DCRM 2.0: Multispecialty practice recommendations for the management of diabetes, cardiorenal, and metabolic diseases.
    Metabolism. 2024 Jun 4:155931. doi: 10.1016/j.metabol.2024.155931.
    >> Share

  81. SABATINI S, Nolan JJ, O'Donoghue G, Kennedy A, et al
    Baseline phenotypes with preserved beta-cell function and high insulin concentrations have the best improvements in glucose tolerance after weight loss: results from the prospective DEXLIFE and EGIR-RISC studies.
    Metabolism. 2024;155:155910.
    >> Share

    May 2024
  82. HUTTASCH M, Roden M, Kahl S
    Obesity and MASLD: Is weight loss the (only) key to treat metabolic liver disease?
    Metabolism. 2024 May 21:155937. doi: 10.1016/j.metabol.2024.155937.
    >> Share

  83. LIAN LY, Targher G, Byrne CD, Liu WY, et al
    Resmetirom for MASH patients with diabetes: challenges and opportunities in the real world.
    Metabolism. 2024 May 15:155935. doi: 10.1016/j.metabol.2024.155935.
    >> Share

    April 2024
  84. JEREMIAH SS, Moin ASM, Butler AE
    Virus-induced diabetes mellitus, revisiting infection etiology in light of SARS-CoV-2.
    Metabolism. 2024 Apr 18:155917. doi: 10.1016/j.metabol.2024.155917.
    >> Share

  85. ROSENDO-SILVA D, Gomes PB, Rodrigues T, Viana S, et al
    Clinical and molecular profiling of human visceral adipose tissue reveals impairment of vascular architecture and remodeling as an early hallmark of dysfunction.
    Metabolism. 2024;153:155788.
    >> Share

    March 2024
  86. HE Y, Qu L
    The role and mechanisms of non-coding RNAs in diabetic peripheral neuropathy.
    Metabolism. 2024 Mar 8:155833. doi: 10.1016/j.metabol.2024.155833.
    >> Share

    November 2023
  87. ALABDULJABBAR K, le Roux CW
    Pharmacotherapy before and after bariatric surgery.
    Metabolism. 2023;148:155692.
    >> Share

  88. SONG E, Hwang SY, Park MJ, Jang A, et al
    Additive impact of diabetes and sarcopenia on all-cause and cardiovascular mortality: A longitudinal nationwide population-based study.
    Metabolism. 2023;148:155678.
    >> Share


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