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Articles published in
J Clin Invest
    May 2024
  1. DING J, Nguyen AT, Lohman K, Hensley MT, et al
    LXR signaling pathways link cholesterol metabolism with risk for prediabetes and diabetes.
    J Clin Invest. 2024;134:e173278.
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    April 2024
  2. YANG J, Zhuang H, Li J, Nunez-Nescolarde AB, et al
    The secreted micropeptide C4orf48 enhances renal fibrosis via an RNA-binding mechanism.
    J Clin Invest. 2024;134:e178392.
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    March 2024
  3. DI GIUSEPPE G, Soldovieri L, Ciccarelli G, Ferraro PM, et al
    Reduced incretin effect precedes diabetes development following duodenopancreatectomy in subjects without diabetes.
    J Clin Invest. 2024 Mar 12:e175133. doi: 10.1172/JCI175133.
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  4. DEFRONZO RA
    SGLT2 inhibitors: cardiorenal metabolic drugs for the ages.
    J Clin Invest. 2024;134:e177625.
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    February 2024
  5. BERGMAN RN
    Pancreatic beta cell function versus insulin resistance: application of the hyperbolic law of glucose tolerance.
    J Clin Invest. 2024;134:e176738.
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    January 2024
  6. DRUCKER DJ
    The GLP-1 journey: from discovery science to therapeutic impact.
    J Clin Invest. 2024;134:e175634.
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  7. HAIDER N, Kahn CR
    Interactions among insulin resistance, epigenetics, and donor sex in gene expression regulation of iPSC-derived myoblasts.
    J Clin Invest. 2024;134:e172333.
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    November 2023
  8. GOVINDARAJAH V, Sakabe M, Good S, Solomon M, et al
    Gestational diabetes in mice induces hematopoietic memory that impacts the long-term health of the offspring.
    J Clin Invest. 2023 Nov 21:e169730. doi: 10.1172/JCI169730.
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  9. WELCH AA, Farahani RA, Egan AM, Laurenti MC, et al
    Glucagon-like peptide-1 receptor blockade impairs islet secretion and glucose metabolism in humans.
    J Clin Invest. 2023;133:e173495.
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    October 2023
  10. DREXLER Y, Fornoni A
    Adenine crosses the biomarker bridge: from 'omics to treatment in diabetic kidney disease.
    J Clin Invest. 2023;133:e174015.
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  11. BLOT G, Karadayi R, Przegralek L, Sartoris TM, et al
    Perilipin 2-positive mononuclear phagocytes accumulate in the diabetic retina and promote PPARgamma-dependent vasodegeneration.
    J Clin Invest. 2023;133:e161348.
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  12. ZHOU C, She X, Gu C, Hu Y, et al
    FTO fuels diabetes-induced vascular endothelial dysfunction associated with inflammation by erasing m6A methylation of TNIP1.
    J Clin Invest. 2023;133:e160517.
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  13. GOU Y, Schwartz MW
    How should we think about the unprecedented weight loss efficacy of incretin-mimetic drugs?
    J Clin Invest. 2023;133:e174597.
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    September 2023
  14. STAMATERIS RE, Landa-Galvan HV, Sharma RB, Darko C, et al
    Noncanonical CDK4 signaling rescues diabetes in a mouse model by promoting beta cell differentiation.
    J Clin Invest. 2023;133:e166490.
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    August 2023
  15. SHARMA K, Zhang G, Hansen J, Bjornstad P, et al
    Endogenous adenine mediates kidney injury in diabetic models and predicts diabetic kidney disease in patients.
    J Clin Invest. 2023 Aug 24:e170341. doi: 10.1172/JCI170341.
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  16. SPANIER JA, Fung V, Wardell CM, Alkhatib MH, et al
    Insulin B peptide-MHC class II-specific chimeric antigen receptor-Tregs prevent autoimmune diabetes in mice.
    J Clin Invest. 2023 Aug 10:e168601. doi: 10.1172/JCI168601.
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    July 2023
  17. SATO M, Neufeld EB, Playford MP, Lei Y, et al
    Cell-free high-density lipoprotein-specific phospholipid efflux assay predicts incident cardiovascular disease.
    J Clin Invest. 2023 Jul 20:e165370. doi: 10.1172/JCI165370.
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  18. BAHN YJ, Yadav H, Piaggi P, Abel BS, et al
    CDK4-E2F3 signals enhance oxidative skeletal muscle fiber numbers and function to affect myogenesis and metabolism.
    J Clin Invest. 2023;133:e162479.
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    June 2023
  19. SPINELLI R, Baboota RK, Gogg S, Beguinot F, et al
    Increased cell senescence in human metabolic disorders.
    J Clin Invest. 2023;133:e169922.
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    May 2023
  20. ZHANG J, Sharma D, Dinabandhu A, Sanchez J, et al
    Targeting hypoxia-inducible factors with 32-134D safely and effectively treats diabetic eye disease in mice.
    J Clin Invest. 2023 May 25:e163290. doi: 10.1172/JCI163290.
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  21. EADE KT, Ansell BRE, Giles S, Fallon R, et al
    iPSC-derived retinal pigmented epithelial cells from patients with macular telangiectasia show decreased mitochondrial function.
    J Clin Invest. 2023;133:e163771.
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    April 2023
  22. WORTHAM M, Liu F, Harrington AR, Fleischman JY, et al
    Nutrient regulation of the islet epigenome controls adaptive insulin secretion.
    J Clin Invest. 2023;133:e165208.
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    March 2023
  23. ALBARIQI MM, Versteeg S, Brakkee EM, Coert JH, et al
    Human IAPP is a contributor to painful diabetic peripheral neuropathy.
    J Clin Invest. 2023 Mar 14:e156993. doi: 10.1172/JCI156993.
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  24. TUTTLE KR
    Digging deep into cells to find mechanisms of kidney protection by SGLT2 inhibitors.
    J Clin Invest. 2023;133:e167700.
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    February 2023
  25. MOHANDES S, Doke T, Hu H, Mukhi D, et al
    Molecular pathways that drive diabetic kidney disease.
    J Clin Invest. 2023;133:e165654.
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  26. KIM MH, Li Y, Zheng Q, Jiang L, et al
    LepRb+ cell-specific deletion of Slug mitigates obesity and nonalcoholic fatty liver disease in mice.
    J Clin Invest. 2023;133:e156722.
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  27. BASS J, Tschop MH, Beutler LR
    Dual gut hormone receptor agonists for diabetes and obesity.
    J Clin Invest. 2023;133:e167952.
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  28. KALLAPUR A, Sallam T
    Endothelial cells LEENE on noncoding RNAs in diabetic vasculopathy.
    J Clin Invest. 2023;133:e167047.
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    January 2023
  29. BACOS K, Perfilyev A, Karagiannopoulos A, Cowan E, et al
    Type 2 diabetes candidate genes, including PAX5, cause impaired insulin secretion in human pancreatic islets.
    J Clin Invest. 2023 Jan 19:e163612. doi: 10.1172/JCI163612.
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  30. SCHAUB JA, AlAkwaa FM, McCown PJ, Naik AS, et al
    SGLT2 inhibitors mitigate kidney tubular metabolic and mTORC1 perturbations in youth onset type 2 diabetes.
    J Clin Invest. 2023 Jan 13:e164486. doi: 10.1172/JCI164486.
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  31. KHURANA I, Kaipananickal H, Maxwell S, Birkelund S, et al
    Reduced methylation corresponds with diabetic nephropathy risk in type 1 diabetes reduced methylation corresponds with diabetic nephropathy risk.
    J Clin Invest. 2023 Jan 12:e160959. doi: 10.1172/JCI160959.
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    December 2022
  32. TANG X, Luo Y, Yuan D, Calandrelli R, et al
    Long non-coding RNA LEENE promotes angiogenesis and ischemic recovery in diabetes models.
    J Clin Invest. 2022 Dec 13:e161759. doi: 10.1172/JCI161759.
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    October 2022
  33. DU W, Wang J, Kuo T, Wang L, et al
    Pharmacological conversion of gut epithelial cells into insulin-producing cells lowers glycemia in diabetic animals.
    J Clin Invest. 2022 Oct 25. pii: 162720. doi: 10.1172/JCI162720.
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  34. WARNCKE K, Weiss A, Achenbach P, von dem Berge T, et al
    Elevations in blood glucose before and after the appearance of islet autoantibodies in children.
    J Clin Invest. 2022;132.
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  35. DONATH MY
    Type 1 diabetes: what is the role of autoimmunity in beta cell death?
    J Clin Invest. 2022;132.
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  36. PORRETT PM, Locke JE
    A roadmap for human trials of xenotransplantation.
    J Clin Invest. 2022;132.
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    August 2022
  37. WANG P, Karakose E, Argmann C, Wang H, et al
    Disrupting the DREAM complex enables proliferation of adult human pancreatic beta cells.
    J Clin Invest. 2022;132.
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    June 2022
  38. DOLIBA NM, Rozo AV, Roman J, Qin W, et al
    alpha Cell dysfunction in islets from nondiabetic, glutamic acid decarboxylase autoantibody-positive individuals.
    J Clin Invest. 2022;132.
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    May 2022
  39. GUZMAN S, Dragan M, Kwon H, de Oliveira V, et al
    Targeting hepatic kisspeptin receptor ameliorates nonalcoholic fatty liver disease in a mouse model.
    J Clin Invest. 2022;132.
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  40. MILLER B, Kim SJ, Kumagai H, Yen K, et al
    Mitochondria-derived peptides in aging and healthspan.
    J Clin Invest. 2022;132.
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    March 2022
  41. BOUTAGY NE, Singh AK, Sessa WC
    Targeting the vasculature in cardiometabolic disease.
    J Clin Invest. 2022;132.
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  42. TRAVERS JG, Tharp CA, Rubino M, McKinsey TA, et al
    Therapeutic targets for cardiac fibrosis: from old school to next-gen.
    J Clin Invest. 2022;132.
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    February 2022
  43. BUTLER PC, Gale EA
    Reversing type 1 diabetes with stem cell-derived islets: a step closer to the dream?
    J Clin Invest. 2022;132.
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    January 2022
  44. ANDERSEN RC, Schmidt JH, Rombach J, Lycas MD, et al
    Coding variants identified in diabetic patients alter PICK1 BAR domain function in insulin granule biogenesis.
    J Clin Invest. 2022 Jan 25. pii: 144904. doi: 10.1172/JCI144904.
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    December 2021
  45. SON J, Ding H, Farb TB, Efanov AM, et al
    BACH2 inhibition reverses beta cell failure in type 2 diabetes models.
    J Clin Invest. 2021;131.
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  46. IMAI Y
    Deciphering regulatory protein activity in human pancreatic islets via reverse engineering of single-cell sequencing data.
    J Clin Invest. 2021;131.
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    November 2021
  47. PASTAR I, Sawaya AP, Marjanovic J, Burgess JL, et al
    Intracellular Staphylococcus aureus triggers pyroptosis and contributes to inhibition of healing due to Perforin-2 suppression.
    J Clin Invest. 2021 Nov 2. pii: 133727. doi: 10.1172/JCI133727.
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  48. TOKARZ VL, Delgado-Olguin P, Klip A
    Deprogram and reprogram to solve the riddle of insulin resistance.
    J Clin Invest. 2021;131.
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    September 2021
  49. BHARDWAJ G, Penniman CM, Jena J, Suarez Beltran PA, et al
    Insulin and IGF-1 receptors regulate complex I-dependent mitochondrial bioenergetics and supercomplexes via FoxOs in muscle.
    J Clin Invest. 2021;131.
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  50. BROWN MR, Holmes H, Rakshit K, Javeed N, et al
    Electrogenic sodium bicarbonate cotransporter NBCe1 regulates pancreatic beta cell function in type 2 diabetes.
    J Clin Invest. 2021;131.
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    June 2021
  51. SINGH AK, Netea MG, Bishai WR
    BCG turns 100: its nontraditional uses against viruses, cancer, and immunologic diseases.
    J Clin Invest. 2021;131.
    >> Share

    May 2021
  52. LEE SJ
    Targeting the myostatin signaling pathway to treat muscle loss and metabolic dysfunction.
    J Clin Invest. 2021;131.
    >> Share


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