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Articles published in
J Clin Invest
    March 2026
  1. GUO C, Sodhi A
    Molecular stress and neurovascular injury in the diabetic retina.
    J Clin Invest. 2026;136:e200945.
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    February 2026
  2. FILIP P, Canna A, Grohn H, Moheet AA, et al
    Disrupted Neurovascular-Endocrine Coupling in Type 1 Diabetes with impaired awareness of hypoglycaemia.
    J Clin Invest. 2026 Feb 19:e199725. doi: 10.1172/JCI199725.
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  3. HEROLD KC, Perdigoto AL
    Predicting checkpoint inhibitor-associated autoimmune diabetes: prospects and limitations.
    J Clin Invest. 2026;136:e202477.
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  4. KAHLES F, Birkenfeld AL, Marx N
    GLP-1 and the cardiovascular system.
    J Clin Invest. 2026;136:e194748.
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  5. JALLEH RJ, Talley NJ, Horowitz M, Nauck MA, et al
    The science of safety: adverse effects of GLP-1 receptor agonists as glucose-lowering and obesity medications.
    J Clin Invest. 2026;136:e194740.
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  6. AHMED A, Yadav P, Jensen M, Geasland K, et al
    Mitochondrial oxidants promote platelet activation and thrombotic susceptibility in prediabetes.
    J Clin Invest. 2025;136:e195662.
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  7. NAIK AS, Alakwaa FM, Nair V, McCown PJ, et al
    Metabolic surgery mitigates early kidney injury in obese youth with diabetes by suppressing mTORC1/JAK-STAT signaling.
    J Clin Invest. 2026 Feb 3:e198545. doi: 10.1172/JCI198545.
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    January 2026
  8. AUSTIN G, Tomas A
    Signaling architecture of the glucagon-like peptide-1 receptor.
    J Clin Invest. 2026;136:e194752.
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  9. CARDOSO P, Dennis JM, Pearson ER
    GLP-1RA precision medicine in people with type 2 diabetes: current insights and future prospects.
    J Clin Invest. 2026;136:e194742.
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  10. PERSAUD SP, DiPersio JF
    Preventing graft re-JAK-tion: safer transplant conditioning enables murine islet allograft tolerance and diabetes reversal.
    J Clin Invest. 2026;136:e201105.
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  11. REISER J, Hayek SS, Sever S
    The role of suPAR and related proteins in kidney, heart diseases, and diabetes.
    J Clin Invest. 2026;136:e197141.
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  12. GILANI A, Stein BD, Hoffmann A, Pereira de Lima R, et al
    Secretory kinase FAM20C triggers adipocyte dysfunction, inciting insulin resistance and inflammation in obesity.
    J Clin Invest. 2025;136:e191075.
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    December 2025
  13. CHEN HC, Bang MF, Wang HH, Shpargel KB, et al
    UTX coordinates TCF1 and STAT3 to control progenitor CD8+ T cell fate in autoimmune diabetes.
    J Clin Invest. 2025 Dec 16:e196325. doi: 10.1172/JCI196325.
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  14. HUANG X, Liu M, Gonzalez MV, Debnath R, et al
    Diabetes exacerbates destructive inflammation by activating theCD137L-CD137 axis in dendritic and gammadelta T-cells.
    J Clin Invest. 2025 Dec 11:e193289. doi: 10.1172/JCI193289.
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  15. BLACK PN, DiRusso CC
    FATP2 at the crossroads of fatty acid transport, lipotoxicity, and complex disease.
    J Clin Invest. 2025;135:e199873.
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  16. EIZIRIK DL, Zimath PL
    Diabetes research enters the biobank era: searching for the truth in a deep well.
    J Clin Invest. 2025;135:e199728.
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  17. KHAN S, Gaivin RJ, Liu Z, Li V, et al
    Fatty acid transport protein 2 inhibition enhances glucose tolerance through alpha cell-mediated GLP-1 secretion.
    J Clin Invest. 2025;135:e192011.
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    November 2025
  18. WU L, Wentworth JM, Liddle C, Fewings N, et al
    Pancreatic volume and immune biomarkers predict checkpoint inhibitor-associated autoimmune diabetes in humans.
    J Clin Invest. 2025 Nov 20:e192938. doi: 10.1172/JCI192938.
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  19. BHAGCHANDANI P, Ramos SA, Rodriguez B, Gu X, et al
    Curing autoimmune diabetes in mice with islet and hematopoietic cell transplantation after CD117 antibody-based conditioning.
    J Clin Invest. 2025 Nov 18:e190034. doi: 10.1172/JCI190034.
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  20. VALENCIA-RINCON E, Rai R, Chandra V, Wellberg EA, et al
    GLP-1 receptor agonists and cancer: current clinical evidence and translational opportunities for preclinical research.
    J Clin Invest. 2025;135:e194743.
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  21. COOPER ME, van Raalte DH
    GLP-1 agonists in the treatment of chronic kidney disease in type 2 diabetes and obesity.
    J Clin Invest. 2025;135:e194749.
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  22. WONG CK, Drucker DJ
    Antiinflammatory actions of glucagon-like peptide-1-based therapies beyond metabolic benefits.
    J Clin Invest. 2025;135:e194751.
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  23. TAMBRALLI A, Knight JS
    Neutrophils take center stage in VEXAS syndrome pathogenesis.
    J Clin Invest. 2025;135:e199299.
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    October 2025
  24. KATZ LS, Scott DK, Stewart AF
    SIRT2 puts the brakes on human beta cell proliferation: therapeutic opportunities and next challenges.
    J Clin Invest. 2025;135:e197142.
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    September 2025
  25. SASSI G, Lemaitre P, Fernandez Calvo L, Lodi F, et al
    Neutrophil-enriched gene signature correlates with teplizumab therapy resistance in different stages of type 1 diabetes.
    J Clin Invest. 2025 Sep 30:e176403. doi: 10.1172/JCI176403.
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  26. DOS SANTOS T, Dai XQ, Jones RC, Spigelman AF, et al
    Altered immune and metabolic molecular pathways drive islet cell dysfunction in human type 1 diabetes.
    J Clin Invest. 2025 Sep 30:e195267. doi: 10.1172/JCI195267.
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  27. VIRGILIO E, Tielens S, Bonfield G, Nian FS, et al
    Recessive TMEM167A variants cause neonatal diabetes, microcephaly and epilepsy syndrome.
    J Clin Invest. 2025 Sep 9:e195756. doi: 10.1172/JCI195756.
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  28. MEAKIN PJ, Coull BM, Tuharska Z, McCaffery C, et al
    Expression of Concern for Elevated circulating amyloid concentrations in obesity and diabetes promote vascular dysfunction.
    J Clin Invest. 2025;135:e199125.
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    August 2025
  29. TAVARES-FERREIRA D, Shen BQ, Mwirigi JM, Shiers S, et al
    Cell and molecular profiles in peripheral nerves shift toward inflammatory phenotypes in diabetic peripheral neuropathy.
    J Clin Invest. 2025 Aug 19:e184075. doi: 10.1172/JCI184075.
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  30. KONG YX, Rehan R, Moreno CL, Madsen S, et al
    SEC61B regulates calcium flux and platelet hyperreactivity in diabetes.
    J Clin Invest. 2025;135:e184597.
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  31. MIRZADEH Z, Morton GJ, Hirsch IB, Schwartz MW, et al
    An unexpected role for the brain in the pathogenesis of diabetic ketoacidosis.
    J Clin Invest. 2025;135:e196357.
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  32. CHOE J, Belmonte P, Crotts S, Nguyen T, et al
    ST8Sia6 overexpression protects pancreatic beta cells from spontaneous autoimmune diabetes in nonobese diabetic mice.
    J Clin Invest. 2025;135:e181207.
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    July 2025
  33. SINGH AK, Bernabucci M, Dvorak NM, Haghighijoo Z, et al
    Sensory neuron-expressed FGF13 controls nociceptive signaling in diabetic neuropathy models.
    J Clin Invest. 2025;135:e183749.
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  34. LI X, Hu J, Huang Y, Zhang H, et al
    Trapalpha deficiency impairs the early events of insulin biosynthesis and glucose homeostasis.
    J Clin Invest. 2025;135:e179845.
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  35. NEWSOME PN, Loomba R
    Therapeutic horizons in metabolic dysfunction-associated steatohepatitis.
    J Clin Invest. 2025;135:e186425.
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    June 2025
  36. TOMLINSON JW
    Should GLP-1 receptor agonist therapy be used to treat obesity in Bardet-Biedl syndrome?
    J Clin Invest. 2025;135:e191822.
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    May 2025
  37. COSTANTINO S, Mohammed SA, Paneni F
    Endothelial dysfunction in patients with type 2 diabetes: the truth is in the blood.
    J Clin Invest. 2025;135:e193128.
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  38. SARKAR M, Kushner T
    Metabolic dysfunction-associated steatotic liver disease and pregnancy.
    J Clin Invest. 2025;135:e186426.
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  39. GOU Y, Glat M, Damian V, Bryan CL, et al
    AgRP neuron hyperactivity drives hyperglycemia in a mouse model of type 2 diabetes.
    J Clin Invest. 2025;135:e189842.
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  40. PETRIE GN, Mayo LM
    GLP-1 receptor agonists for the treatment of alcohol use disorder.
    J Clin Invest. 2025;135:e192414.
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    April 2025
  41. GATTU AK, Tanzer M, Yaron-Barir TM, Johnson JL, et al
    Cell-intrinsic insulin signaling defects in human iPS cell-derived hepatocytes in type 2 diabetes.
    J Clin Invest. 2025;135:e183513.
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    March 2025
  42. COLLADO A, Humoud R, Kontidou E, Eldh M, et al
    Erythrocyte-derived extracellular vesicles induce endothelial dysfunction through arginase-1 and oxidative stress in type 2 diabetes.
    J Clin Invest. 2025 Mar 20:e180900. doi: 10.1172/JCI180900.
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    December 2024
  43. CATTIN-ROY AN, Laffey KG, Le LB, Schrum AG, et al
    Reduced thymic IL-4 impairs negative T cell selection in nonobese diabetic mice.
    J Clin Invest. 2024;134:e163417.
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    October 2024
  44. CHOI YJ, Richard G, Zhang G, Hodgin JB, et al
    Attenuated kidney oxidative metabolism in young adults with type 1 diabetes.
    J Clin Invest. 2024 Oct 22:e183984. doi: 10.1172/JCI183984.
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  45. OTENG AB, Liu L, Cui Y, Gavrilova O, et al
    Activation of Gs signaling in mouse enteroendocrine K-cells greatly improves obesity- and diabetes-related metabolic deficits.
    J Clin Invest. 2024 Oct 22:e182325. doi: 10.1172/JCI182325.
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    September 2024
  46. DOLTON G, Bulek A, Wall A, Thomas H, et al
    HLA A*24:02-restricted T cell receptors cross-recognize bacterial and preproinsulin peptides in type 1 diabetes.
    J Clin Invest. 2024;134:e164535.
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  47. CAPERA J, Dustin ML
    Microbial mimics supersize the pathogenic self-response.
    J Clin Invest. 2024;134:e184046.
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    August 2024
  48. STERLING JK, Rajesh A, Droho S, Gong J, et al
    Retinal perivascular macrophages regulate immune cell infiltration during neuroinflammation in mouse models of ocular disease.
    J Clin Invest. 2024;134:e180904.
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  49. DING J, Nguyen AT, Lohman K, Hensley MT, et al
    LXR signaling pathways link cholesterol metabolism with risk for prediabetes and diabetes.
    J Clin Invest. 2024;134:e185290.
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  50. LLEDO-DELGADO A, Preston-Hurlburt P, Currie S, Clark P, et al
    Teplizumab induces persistent changes in the antigen-speci fi c repertoire in individuals at-risk for type 1 diabetes.
    J Clin Invest. 2024 Aug 13:e177492. doi: 10.1172/JCI177492.
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    July 2024
  51. SCHRADER LA, Ronnekleiv-Kelly SM, Hogenesch JB, Bradfield CA, et al
    Circadian disruption, clock genes, and metabolic health.
    J Clin Invest. 2024;134:e170998.
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    June 2024
  52. MURALIDHARAN C, Huang F, Enriquez JR, Wang JE, et al
    Inhibition of the eukaryotic initiation factor-2-alpha kinase PERK decreases risk of autoimmune diabetes in mice.
    J Clin Invest. 2024 Jun 18:e176136. doi: 10.1172/JCI176136.
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  53. HAEMMERLE MW, Scota AV, Khosravifar M, Varney MJ, et al
    RNA-binding protein PCBP2 regulates pancreatic beta cell function and adaptation to glucose.
    J Clin Invest. 2024;134:e172436.
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    May 2024
  54. DING J, Nguyen AT, Lohman K, Hensley MT, et al
    LXR signaling pathways link cholesterol metabolism with risk for prediabetes and diabetes.
    J Clin Invest. 2024;134:e173278.
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  55. SABADELL-BASALLOTE J, Astiarraga B, Castano C, Ejarque M, et al
    SUCNR1 regulates insulin secretion and glucose elevates the succinate response in people with prediabetes.
    J Clin Invest. 2024;134:e173214.
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    April 2024
  56. YANG J, Zhuang H, Li J, Nunez-Nescolarde AB, et al
    The secreted micropeptide C4orf48 enhances renal fibrosis via an RNA-binding mechanism.
    J Clin Invest. 2024;134:e178392.
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    March 2024
  57. DI GIUSEPPE G, Soldovieri L, Ciccarelli G, Ferraro PM, et al
    Reduced incretin effect precedes diabetes development following duodenopancreatectomy in subjects without diabetes.
    J Clin Invest. 2024 Mar 12:e175133. doi: 10.1172/JCI175133.
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  58. DEFRONZO RA
    SGLT2 inhibitors: cardiorenal metabolic drugs for the ages.
    J Clin Invest. 2024;134:e177625.
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