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Diabetes

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Articles published in
J Clin Invest
    July 2021
  1. SINGH AK, Chaube B, Zhang X, Sun J, et al
    Hepatocyte-specific suppression of ANGPTL4 improves obesity-associated diabetes and mitigates atherosclerosis in mice.
    J Clin Invest. 2021 Jul 13. pii: e140989. doi: 10.1172/JCI140989.
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    June 2021
  2. WEIR GC, Bonner-Weir S
    Reduced glucose-induced first-phase insulin release is a danger signal that predicts diabetes.
    J Clin Invest. 2021;131.
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    May 2021
  3. CAO A, Li J, Asadi M, Basgen JM, et al
    DACH1 protects podocytes from experimental diabetic injury and modulates PTIP-H3K4Me3 activity.
    J Clin Invest. 2021;131.
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    April 2021
  4. MEZZA T, Ferraro PM, Di Giuseppe G, Moffa S, et al
    Duodenopancreatectomy as a model to demonstrate the fundamental role of dysfunctional beta cell in predicting diabetes.
    J Clin Invest. 2021 Apr 27. pii: 146788. doi: 10.1172/JCI146788.
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    March 2021
  5. POWERS AC
    Type 1 diabetes mellitus: much progress, many opportunities.
    J Clin Invest. 2021 Mar 24. pii: 142242. doi: 10.1172/JCI142242.
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    February 2021
  6. GUBITOSI-KLUG RA, Braffett BH, Hitt S, Arends V, et al
    Residual beta cell function in long-term type 1 diabetes associates with reduced incidence of hypoglycemia.
    J Clin Invest. 2021;131.
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  7. ZHANG H, Colclough K, Gloyn AL, Pollin TI, et al
    Monogenic diabetes: a gateway to precision medicine in diabetes.
    J Clin Invest. 2021;131.
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    January 2021
  8. TAYLOR SI, Yazdi ZS, Beitelshees AL
    Pharmacological treatment of hyperglycemia in type 2 diabetes.
    J Clin Invest. 2021;131.
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  9. LENNERZ BS, Koutnik AP, Azova S, Wolfsdorf JI, et al
    Carbohydrate restriction for diabetes: rediscovering centuries-old wisdom.
    J Clin Invest. 2021;131.
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    November 2020
  10. ODUORI OS, Murao N, Shimomura K, Takahashi H, et al
    Gs/Gq signaling switch in beta cells defines incretin effectiveness in diabetes.
    J Clin Invest. 2020 Nov 16. pii: 140046. doi: 10.1172/JCI140046.
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  11. NICHOLS CG, York NW, Remedi MS
    Preferential Gq signaling in diabetes: an electrical switch in incretin action and in diabetes progression?
    J Clin Invest. 2020 Nov 16. pii: 143199. doi: 10.1172/JCI143199.
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  12. POLLIN TI, Taylor SI
    YIPF5 mutations cause neonatal diabetes and microcephaly: progress for precision medicine and mechanistic understanding.
    J Clin Invest. 2020 Nov 9. pii: 142364. doi: 10.1172/JCI142364.
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  13. DE FRANCO E, Lytrivi M, Ibrahim H, Montaser H, et al
    YIPF5 mutations cause neonatal diabetes and microcephaly through endoplasmic reticulum stress.
    J Clin Invest. 2020 Nov 9. pii: 141455. doi: 10.1172/JCI141455.
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  14. MESUBI OO, Rokita AG, Abrol N, Wu Y, et al
    Oxidized-CaMKII and O-GlcNAcylation cause increased atrial fibrillation in diabetic mice by distinct mechanisms.
    J Clin Invest. 2020 Nov 5. pii: 95747. doi: 10.1172/JCI95747.
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    October 2020
  15. CHEN A, Feng Y, Lai H, Ju W, et al
    Soluble RARRES1 induces podocyte apoptosis to promote glomerular disease progression.
    J Clin Invest. 2020;130:5523-5535.
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  16. NEILL US
    A conversation with C. Ronald Kahn.
    J Clin Invest. 2020;130:5029-5030.
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  17. PRABHAKAR NR, Peng YJ, Nanduri J
    Hypoxia-inducible factors and obstructive sleep apnea.
    J Clin Invest. 2020;130:5042-5051.
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    August 2020
  18. LIU Y, Wang X, Zhu Y, Zhang M, et al
    Haploidentical mixed chimerism cures autoimmunity in established type 1 diabetic mice.
    J Clin Invest. 2020 Aug 20. pii: 131799. doi: 10.1172/JCI131799.
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  19. GUNTON JE
    Hypoxia inducible factors and diabetes.
    J Clin Invest. 2020 Aug 18. pii: 137556. doi: 10.1172/JCI137556.
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  20. MA Z, Li L, Livingston MJ, Zhang D, et al
    p53/microRNA-214/ULK1 axis impairs renal tubular autophagy in diabetic kidney disease.
    J Clin Invest. 2020 Aug 17. pii: 135536. doi: 10.1172/JCI135536.
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  21. SCHRIEVER SC, Kabra DG, Pfuhlmann K, Baumann P, et al
    Type 2 diabetes risk gene Dusp8 regulates hypothalamic Jnk signaling and insulin sensitivity.
    J Clin Invest. 2020 Aug 11. pii: 136363. doi: 10.1172/JCI136363.
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    July 2020
  22. DEHNAD A, Fan W, Jiang JX, Fish SR, et al
    AGER1 downregulation associates with fibrosis in nonalcoholic steatohepatitis and type 2 diabetes.
    J Clin Invest. 2020 Jul 13. pii: 133051. doi: 10.1172/JCI133051.
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  23. LU Y, Wang E, Chen Y, Zhou B, et al
    Obesity-induced excess of 17-hydroxyprogesterone promotes hyperglycemia through activation of glucocorticoid receptor.
    J Clin Invest. 2020;130:3791-3804.
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  24. SHRESTHA N, Liu T, Ji Y, Reinert RB, et al
    Sel1L-Hrd1 ER-associated degradation maintains beta cell identity via TGF-beta signaling.
    J Clin Invest. 2020;130:3499-3510.
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    June 2020
  25. OTTO M, Bucher C, Liu W, Muller M, et al
    12(S)-HETE mediates diabetes induced endothelial dysfunction by activating intracellular endothelial cell TRPV1.
    J Clin Invest. 2020 Jun 25. pii: 136621. doi: 10.1172/JCI136621.
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    May 2020
  26. MEAKIN PJ, Coull BM, Tuharska Z, McCaffery C, et al
    Elevated circulating amyloid concentrations in obesity and diabetes promote vascular dysfunction.
    J Clin Invest. 2020 May 14. pii: 122237. doi: 10.1172/JCI122237.
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  27. LIU Y, Lin H, Jiang L, Shang Q, et al
    Hepatic Slug epigenetically promotes liver lipogenesis, fatty liver disease, and type 2 diabetes.
    J Clin Invest. 2020 May 4. pii: 128073. doi: 10.1172/JCI128073.
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  28. WEEKS O, Bosse GD, Oderberg IM, Akle S, et al
    Fetal alcohol spectrum disorder predisposes to metabolic abnormalities in adulthood.
    J Clin Invest. 2020;130:2252-2269.
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    April 2020
  29. JIANG Q, Liu C, Li C, Xu S, et al
    Circular RNA-ZNF532 regulates diabetes-induced retinal pericyte degeneration and vascular dysfunction.
    J Clin Invest. 2020 Apr 28. pii: 123353. doi: 10.1172/JCI123353.
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    March 2020
  30. NEILL US
    A conversation with Barbara Kahn.
    J Clin Invest. 2020;130:1053-1054.
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    January 2020
  31. RICKELS MR, Evans-Molina C, Bahnson HT, Ylescupidez A, et al
    High residual C-peptide likely contributes to glycemic control in type 1 diabetes.
    J Clin Invest. 2020 Jan 2. pii: 134057. doi: 10.1172/JCI134057.
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    December 2019
  32. WIEDEMAN AE, Muir VS, Rosasco MG, DeBerg HA, et al
    Autoreactive CD8+ T cell exhaustion distinguishes subjects with slow type 1 diabetes progression.
    J Clin Invest. 2019 Dec 9. pii: 126595. doi: 10.1172/JCI126595.
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  33. ELLARD S, Colclough K, Patel KA, Hattersley AT, et al
    Prediction algorithms: pitfalls in interpreting genetic variants of autosomal dominant monogenic diabetes.
    J Clin Invest. 2019 Dec 9. pii: 133516. doi: 10.1172/JCI133516.
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    October 2019
  34. LAM AN, Aksit MA, Vecchio-Pagan B, Shelton CA, et al
    Increased expression of anion transporter SLC26A9 delays diabetes onset in cystic fibrosis.
    J Clin Invest. 2019 Oct 3. pii: 129833. doi: 10.1172/JCI129833.
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    September 2019
  35. MEYER MM
    Trials and tribulations of diabetes: a patient's perspective.
    J Clin Invest. 2019 Sep 23. pii: 132144. doi: 10.1172/JCI132144.
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  36. SODHI A, Ma T, Menon D, Deshpande M, et al
    Angiopoietin-like 4 binds neuropilins and cooperates with VEGF to induce diabetic macular edema.
    J Clin Invest. 2019 Sep 23. pii: 120879. doi: 10.1172/JCI120879.
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    August 2019
  37. GINSBERG HN, Reyes-Soffer G
    Is APOC3 the driver of cardiovascular disease in people with type I diabetes mellitus?
    J Clin Invest. 2019 Aug 26. pii: 131333. doi: 10.1172/JCI131333.
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  38. HUDISH LI, Reusch JE, Sussel L
    beta Cell dysfunction during progression of metabolic syndrome to type 2 diabetes.
    J Clin Invest. 2019 Aug 19. pii: 129188. doi: 10.1172/JCI129188.
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  39. HAMAD ARA, Sadasivam M, Rabb H
    Hybrid lipids, peptides, and lymphocytes: new era in type 1 diabetes research.
    J Clin Invest. 2019;130.
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  40. SYED I, Rubin de Celis MF, Mohan JF, Moraes-Vieira PM, et al
    PAHSAs attenuate immune responses and promote beta cell survival in autoimmune diabetic mice.
    J Clin Invest. 2019;129.
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  41. MOORE PC, Cortez JT, Chamberlain CE, Alba D, et al
    Elastase 3B mutation links to familial pancreatitis with diabetes and pancreatic adenocarcinoma.
    J Clin Invest. 2019;130.
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    July 2019
  42. KELLER MP, Rabaglia ME, Schueler KL, Stapleton DS, et al
    Gene loci associated with insulin secretion in islets from non-diabetic mice.
    J Clin Invest. 2019;130.
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  43. BROWN JM, Scarlett JM, Schwartz MW
    Rethinking the role of the brain in glucose homeostasis and diabetes pathogenesis.
    J Clin Invest. 2019;130.
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  44. KANTER JE, Shao B, Kramer F, Barnhart S, et al
    Increased apolipoprotein C3 drives cardiovascular risk in type 1 diabetes.
    J Clin Invest. 2019;130.
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  45. JAAFAR R, Tran S, Shah A, Sun G, et al
    mTORC1 to AMPK switching underlies beta-cell metabolic plasticity during maturation and diabetes.
    J Clin Invest. 2019;130.
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  46. YU MG, Keenan HA, Shah HS, Frodsham SG, et al
    Residual beta cell function and monogenic variants in long-duration type 1 diabetes patients.
    J Clin Invest. 2019;130.
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    June 2019
  47. SYED AU, Reddy GR, Ghosh D, Prada MP, et al
    Adenylyl cyclase 5-generated cAMP controls cerebral vascular reactivity during diabetic hyperglycemia.
    J Clin Invest. 2019;130.
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    May 2019
  48. GALVAN DL, Long J, Green N, Chang BH, et al
    Drp1S600 phosphorylation regulates mitochondrial fission and progression of nephropathy in diabetic mice.
    J Clin Invest. 2019;130.
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    April 2019
  49. COHEN TS, Takahashi V, Bonnell J, Tovchigrechko A, et al
    Staphylococcus aureus drives expansion of low-density neutrophils in diabetic mice.
    J Clin Invest. 2019;130.
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    February 2019
  50. LI Y, Hu Q, Li C, Liang K, et al
    PTEN-induced partial epithelial-mesenchymal transition drives diabetic kidney disease.
    J Clin Invest. 2019 Feb 11. pii: 121987. doi: 10.1172/JCI121987.
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    January 2019
  51. GUERRA C, Navarro P, Valverde AM, Arribas M, et al
    Brown adipose tissue-specific insulin receptor knockout shows diabetic phenotype without insulin resistance.
    J Clin Invest. 2019;129:437.
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    November 2018
  52. ZASLOFF M
    Why are diabetics prone to kidney infections?
    J Clin Invest. 2018 Nov 12. pii: 124922. doi: 10.1172/JCI124922.
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    August 2018
  53. WU H, Rahman HNA, Dong Y, Liu X, et al
    Epsin deficiency promotes lymphangiogenesis through regulation of VEGFR3 degradation in diabetes.
    J Clin Invest. 2018 Aug 13. pii: 96063. doi: 10.1172/JCI96063.
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    July 2018
  54. HSU CY, Yeh LT, Fu SH, Chien MW, et al
    SUMO-defective c-Maf preferentially transactivates Il21 to exacerbate autoimmune diabetes.
    J Clin Invest. 2018 Jul 30. pii: 98786. doi: 10.1172/JCI98786.
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    May 2018
  55. YEO L, Woodwyk A, Sood S, Lorenc A, et al
    Autoreactive T effector memory differentiation mirrors beta-cell function in type 1 diabetes.
    J Clin Invest. 2018 May 31. pii: 120555. doi: 10.1172/JCI120555.
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    March 2018
  56. JAYARAJ ND, Bhattacharyya BJ, Belmadani AA, Ren D, et al
    Reducing CXCR4-mediated nociceptor hyperexcitability reverses painful diabetic neuropathy.
    J Clin Invest. 2018 Mar 13. pii: 92117. doi: 10.1172/JCI92117.
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    February 2018
  57. OSTROV DA, Alkanani A, McDaniel KA, Case S, et al
    Methyldopa blocks MHC class II binding to disease-specific antigens in autoimmune diabetes.
    J Clin Invest. 2018 Feb 13. pii: 97739. doi: 10.1172/JCI97739.
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  58. TAYLOR SI, Leslie BR
    Cardiovascular outcome trials of diabetes drugs: lessons learned.
    J Clin Invest. 2018 Feb 12. pii: 99820. doi: 10.1172/JCI99820.
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    January 2018
  59. HWANG JJ, Parikh L, Lacadie C, Seo D, et al
    Hypoglycemia unawareness in type 1 diabetes suppresses brain responses to hypoglycemia.
    J Clin Invest. 2018 Jan 30. pii: 97696. doi: 10.1172/JCI97696.
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    December 2017
  60. DRUCKER DJ, Habener JF, Holst JJ
    Discovery, characterization, and clinical development of the glucagon-like peptides.
    J Clin Invest. 2017;127:4217-4227.
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    October 2017
  61. O'SULLIVAN JF, Morningstar JE, Yang Q, Zheng B, et al
    Dimethylguanidino valeric acid is a marker of liver fat and predicts diabetes.
    J Clin Invest. 2017 Oct 30. pii: 95995. doi: 10.1172/JCI95995.
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  62. ZHU W, Shi DS, Winter JM, Rich BE, et al
    Small GTPase ARF6 controls VEGFR2 trafficking and signaling in diabetic retinopathy.
    J Clin Invest. 2017 Oct 23. pii: 91770. doi: 10.1172/JCI91770.
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    September 2017
  63. BICHET DG, Lussier Y
    Mice deficient for ERAD machinery component Sel1L develop central diabetes insipidus.
    J Clin Invest. 2017 Sep 18. pii: 96839. doi: 10.1172/JCI96839.
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