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Articles published in
J Biol Chem
    June 2024
  1. ZHANG B, Bu C, Wang Q, Chen Q, et al
    Low molecular weight heparin promotes the PPAR pathway by protecting the glycocalyx of cells to delay the progression of diabetic nephropathy.
    J Biol Chem. 2024 Jun 24:107493. doi: 10.1016/j.jbc.2024.107493.
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  2. YAMAGUCHI H, Matsumura T, Sugawa H, Niimi N, et al
    Glucoselysine, a unique advanced glycation end-product of the polyol pathway and its association with vascular complications in type 2 diabetes.
    J Biol Chem. 2024 Jun 13:107479. doi: 10.1016/j.jbc.2024.107479.
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  3. BREUNIG SL, Chapman AM, LeBon J, Quijano JC, et al
    4S-fluorination of ProB29 in insulin lispro slows fibril formation.
    J Biol Chem. 2024;300:107332.
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    March 2024
  4. LI L, Yao Y, Wang Y, Cao J, et al
    G protein-coupled estrogen receptor 1 ameliorates nonalcoholic steatohepatitis through targeting AMPK-dependent signaling.
    J Biol Chem. 2024;300:105661.
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    February 2024
  5. XU J, Zhang D, Ma Y, Du H, et al
    ROS in diabetic atria regulate SK2 degradation by Atrogin-1 through the NF-kappaB signaling pathway.
    J Biol Chem. 2024 Feb 7:105735. doi: 10.1016/j.jbc.2024.105735.
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    January 2024
  6. CHAUDHARY S, Pahwa F, Nanda RK
    Dysregulated cysteine metabolism leads to worsened liver pathology in diabetes-tuberculosis comorbid conditions.
    J Biol Chem. 2024 Jan 8:105634. doi: 10.1016/j.jbc.2024.105634.
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    December 2023
  7. KELLY CJ, Verdegaal AA, Anderson BW, Shaw WL, et al
    Metformin inhibits digestive proteases and impairs protein digestion in mice.
    J Biol Chem. 2023;299:105363.
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  8. USMAN TO, Chhetri G, Yeh H, Dong HH, et al
    Beta-cell compensation and gestational diabetes.
    J Biol Chem. 2023;299:105405.
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    November 2023
  9. WANG CH, Surbhi S, Goraya S, Byun J, et al
    Fatty acids and inflammatory stimuli induce expression of long-chain acyl-CoA synthetase 1 to promote lipid remodeling in diabetic kidney disease.
    J Biol Chem. 2023 Nov 26:105502. doi: 10.1016/j.jbc.2023.105502.
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  10. DUANGKUMPHA K, Jariyasopit N, Wanichthanarak K, Dhakal E, et al
    Correction: GC x GC-TOFMS metabolomics analysis identifies elevated levels of plasma sugars and sugar alcohols in diabetic mellitus patients with kidney failure.
    J Biol Chem. 2023;299:105422.
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  11. CRAWFORD SA, Groegler J, Dang M, Michel C, et al
    Hybrid insulin peptide isomers spontaneously form in pancreatic beta-cells from an aspartic anhydride intermediate.
    J Biol Chem. 2023;299:105264.
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    August 2023
  12. LI L, Long J, Mise K, Poungavrin N, et al
    The Transcription Factor ChREBP Links Mitochondrial Lipidomes to Mitochondrial Morphology and Progression of Diabetic Kidney Disease.
    J Biol Chem. 2023 Aug 21:105185. doi: 10.1016/j.jbc.2023.105185.
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  13. LI L, Wang H, Pang S, Wang L, et al
    rhFGF-21 accelerates corneal epithelial wound healing through the attenuation of oxidative stress and inflammatory mediators in diabetic mice.
    J Biol Chem. 2023 Aug 4:105127. doi: 10.1016/j.jbc.2023.105127.
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  14. ZHANG IX, Herrmann A, Leon J, Jeyarajan S, et al
    ER stress increases expression of intracellular calcium channel RyR1 to modify Ca(2+) homeostasis in pancreatic beta cells.
    J Biol Chem. 2023;299:105065.
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    July 2023
  15. MYAKALA K, Wang XX, Shults NV, Krawczyk E, et al
    NAD metabolism modulates inflammation and mitochondria function in diabetic kidney disease.
    J Biol Chem. 2023 Jul 8:104975. doi: 10.1016/j.jbc.2023.104975.
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    June 2023
  16. WANG AJ, Ren J, Wang A, Hascall VC, et al
    Monocyte Adhesive Hyaluronan Matrix Induced by Hyperglycemia in Diabetic Lung Injuries.
    J Biol Chem. 2023 Jun 30:104995. doi: 10.1016/j.jbc.2023.104995.
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  17. SUNILKUMAR S, VanCleave AM, McCurry CM, Toro AL, et al
    REDD1-dependent GSK3beta dephosphorylation promotes NF-kappaB activation and macrophage infiltration in the retina of diabetic mice.
    J Biol Chem. 2023 Jun 29:104991. doi: 10.1016/j.jbc.2023.104991.
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  18. BANDET CL, Tan-Chen S, Ali-Berrada S, Campana M, et al
    Ceramide analog C2-cer induces a loss in insulin sensitivity in muscle cells through the salvage/recycling pathway.
    J Biol Chem. 2023;299:104815.
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  19. KOLLERITSCH S, Pajed L, Tilp A, Hois V, et al
    Adverse cardiac remodeling augments adipose tissue ss-adrenergic signaling and lipolysis counteracting diet-induced obesity.
    J Biol Chem. 2023;299:104788.
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    May 2023
  20. TRIEGER GW, Pessentheiner AR, Purcell SC, Green CR, et al
    Glycocalyx engineering with heparan sulfate mimetics attenuates Wnt activity during adipogenesis to promote glucose uptake and metabolism.
    J Biol Chem. 2023;299:104611.
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    April 2023
  21. WANG H, Yuan YC, Chang C, Izumi T, et al
    The signaling protein GIV/Girdin mediates the Nephrin-dependent insulin secretion of pancreatic islet beta cells in response to high glucose.
    J Biol Chem. 2023;299:103045.
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  22. LIU J, Offei SD, Yoshimoto FK, Scott EE, et al
    Pyridine-containing substrate analogs are restricted from accessing the human cytochrome P450 8B1 active site by tryptophan 281.
    J Biol Chem. 2023;299:103032.
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    March 2023
  23. LIU S, Kormos BL, Knafels JD, Sahasrabudhe PV, et al
    Structural studies identify angiotensin II receptor blocker-like compounds as branched-chain ketoacid dehydrogenase kinase inhibitors.
    J Biol Chem. 2023;299:102959.
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    February 2023
  24. YAO H, Wang Y, Zhang X, Li P, et al
    Targeting peroxisomal fatty acid oxidation improves hepatic steatosis and insulin resistance in obese mice.
    J Biol Chem. 2023;299:102845.
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    January 2023
  25. BAEK J, Sas K, He C, Nair V, et al
    The Deacylase Sirtuin 5 Reduces Malonylation in Non-mitochondrial Metabolic Pathways in Diabetic Kidney Disease.
    J Biol Chem. 2023 Jan 31:102960. doi: 10.1016/j.jbc.2023.102960.
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    December 2022
  26. PARK S, Oh S, Kim EK
    Glucagon-like peptide-1 analog liraglutide leads to multiple metabolic alterations in diet-induced obese mice.
    J Biol Chem. 2022;298:102682.
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    November 2022
  27. CHEN Y, Li M, Yang Y, Lu Y, et al
    Anti-diabetic drug metformin suppresses tumorigenesis through inhibition of mevalonate pathway enzyme HMGCS1.
    J Biol Chem. 2022 Nov 7:102678. doi: 10.1016/j.jbc.2022.102678.
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  28. WANG XX, Xie C, Libby AE, Ranjit S, et al
    The role of FXR and TGR5 in reversing and preventing progression of Western diet-induced hepatic steatosis, inflammation, and fibrosis in mice.
    J Biol Chem. 2022;298:102530.
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    October 2022
  29. SUNILKUMAR S, Toro AL, McCurry CF, VanCleave AM, et al
    Stress response protein REDD1 promotes diabetes-induced retinal inflammation by sustaining canonical NF-kappaB signaling.
    J Biol Chem. 2022 Oct 26:102638. doi: 10.1016/j.jbc.2022.102638.
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  30. ZHOU Y, Li ZL, Ding L, Zhang XJ, et al
    Long non-coding RNA SNHG5 promotes podocyte injury via the microRNA-26a-5p/TRPC6 pathway in diabetic nephropathy.
    J Biol Chem. 2022 Oct 15:102605. doi: 10.1016/j.jbc.2022.102605.
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  31. VARNEY MJ, Steyaert W, Coucke PJ, Delanghe JR, et al
    G protein-coupled receptor kinase 6 (GRK6) regulates insulin processing and secretion via effects on proinsulin conversion to insulin.
    J Biol Chem. 2022;298:102421.
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  32. YENILMEZ B, Kelly M, Zhang GF, Wetoska N, et al
    Paradoxical activation of transcription factor SREBP1c and de novo lipogenesis by hepatocyte-selective ATP-citrate lyase depletion in obese mice.
    J Biol Chem. 2022;298:102401.
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    September 2022
  33. PEDERSEN SS, Prause M, Williams K, Barres R, et al
    Butyrate inhibits IL-1beta-induced inflammatory gene expression by suppression of NF-kappaB activity in pancreatic beta cells.
    J Biol Chem. 2022;298:102312.
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  34. DAS F, Ghosh-Choudhury N, Maity S, Kasinath BS, et al
    Oncoprotein DJ-1 interacts with mTOR complexes to effect transcription factor Hif1alpha-dependent expression of collagen I (alpha2) during renal fibrosis.
    J Biol Chem. 2022;298:102246.
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    August 2022
  35. DUANGKUMPHA K, Jariyasopit N, Wanichthanarak K, Dhakal E, et al
    GCxGC-TOFMS Metabolomics Analysis Identifies Elevated Levels of Plasma Sugars and Sugar Alcohols in Diabetic Mellitus Patients with Kidney Failure.
    J Biol Chem. 2022 Aug 30:102445. doi: 10.1016/j.jbc.2022.102445.
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  36. LIU J, Carlson HA, Scott EE
    The structure and characterization of human cytochrome P450 8B1 supports future drug design for non-alcoholic fatty liver disease and diabetes.
    J Biol Chem. 2022 Aug 6:102344. doi: 10.1016/j.jbc.2022.102344.
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    May 2022
  37. GIRDHAR K, Thakur S, Gaur P, Choubey A, et al
    Design, synthesis, and biological evaluation of a small molecule oral agonist of the glucagon-like-peptide-1 receptor.
    J Biol Chem. 2022;298:101889.
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  38. SANDERS MJ, Ratinaud Y, Neopane K, Bonhoure N, et al
    Natural (dihydro)phenanthrene plant compounds are direct activators of AMPK through its allosteric drug and metabolite-binding site.
    J Biol Chem. 2022;298:101852.
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    April 2022
  39. ZHONG X, Wang T, Zhang W, Wang M, et al
    ERK/RSK-mediated phosphorylation of Y-box binding protein-1 aggravates diabetic cardiomyopathy by suppressing its interaction with deubiquitinase OTUB1.
    J Biol Chem. 2022 Apr 28:101989. doi: 10.1016/j.jbc.2022.101989.
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  40. CAI H, Wang X, Zhang Z, Chen J, et al
    Moderate l-lactate administration suppresses adipose tissue macrophage M1 polarization to alleviate obesity-associated insulin resistance.
    J Biol Chem. 2022;298:101768.
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  41. RAHIM M, Nakhe AY, Banerjee DR, Overway EM, et al
    Glucose-6-phosphatase catalytic subunit 2 negatively regulates glucose oxidation and insulin secretion in pancreatic beta-cells.
    J Biol Chem. 2022;298:101729.
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    March 2022
  42. KIND L, Raasakka A, Molnes J, Aukrust I, et al
    Structural and biophysical characterization of transcription factor HNF-1A as a tool to study MODY3 diabetes variants.
    J Biol Chem. 2022 Mar 4:101803. doi: 10.1016/j.jbc.2022.101803.
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  43. VERMA G, Bowen A, Gheibi S, Hamilton A, et al
    Ribosomal biogenesis regulator DIMT1 controls beta-cell protein synthesis, mitochondrial function, and insulin secretion.
    J Biol Chem. 2022;298:101692.
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  44. BLANDINO-ROSANO M, Romaguera Llacer P, Lin A, Reddy JK, et al
    Trimethylguanosine synthase 1 is a novel regulator of pancreatic beta-cell mass and function.
    J Biol Chem. 2022;298:101592.
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    February 2022
  45. GUAN G, Xie J, Dai Y, Han H, et al
    TFPI2 suppresses the interaction of TGF-beta2 pathway regulators to promote endothelial-mesenchymal transition in diabetic nephropathy.
    J Biol Chem. 2022 Feb 11:101725. doi: 10.1016/j.jbc.2022.101725.
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  46. WANG Y, Zhang X, Yao H, Chen X, et al
    Peroxisome-generated succinate induces lipid accumulation and oxidative stress in the kidneys of diabetic mice.
    J Biol Chem. 2022 Feb 3:101660. doi: 10.1016/j.jbc.2022.101660.
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  47. WANG X, Yang Y, Zhao D, Zhang S, et al
    Inhibition of high-fat diet-induced obesity via reduction of ER-resident protein Nogo occurs through multiple mechanisms.
    J Biol Chem. 2022;298:101561.
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  48. HODGES WT, Jarasvaraparn C, Ferguson D, Griffett K, et al
    Mitochondrial pyruvate carrier inhibitors improve metabolic parameters in diet-induced obese mice.
    J Biol Chem. 2022;298:101554.
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  49. DOU X, Zhou WY, Ding M, Ma YJ, et al
    The protease SENP2 controls hepatic gluconeogenesis by regulating the SUMOylation of the fuel sensor AMPKalpha.
    J Biol Chem. 2022;298:101544.
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  50. CABRERA O, Ficorilli J, Shaw J, Echeverri F, et al
    Intra-islet glucagon confers beta-cell glucose competence for first-phase insulin secretion and favors GLP-1R stimulation by exogenous glucagon.
    J Biol Chem. 2022;298:101484.
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    January 2022
  51. ZHANG X, Wang Y, Yao H, Deng S, et al
    Peroxisomal beta-oxidation stimulates cholesterol biosynthesis in the liver in diabetic mice.
    J Biol Chem. 2022 Jan 7:101572. doi: 10.1016/j.jbc.2022.101572.
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  52. REILLY AM, Yan S, Huang M, Abhyankar SD, et al
    A high-fat diet catalyzes progression to hyperglycemia in mice with selective impairment of insulin action in Glut4-expressing tissues.
    J Biol Chem. 2022;298:101431.
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    November 2021
  53. VAN LIEMPD S, Cabrera D, Pilzner C, Kollmus H, et al
    Impaired beta-oxidation increases vulnerability to influenza A infection.
    J Biol Chem. 2021;297:101298.
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    October 2021
  54. FARABAUGH KT
    The "Levine effect" and the father of modern diabetes research.
    J Biol Chem. 2021 Oct 27:101356. doi: 10.1016/j.jbc.2021.101356.
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  55. JIN D, Wek SA, Kudlapur NT, Cantara WA, et al
    Disease-associated mutations in a bifunctional aminoacyl-tRNA synthetase gene elicit the integrated stress response.
    J Biol Chem. 2021;297:101203.
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  56. KRALOVA J, Pavliuchenko N, Fabisik M, Ilievova K, et al
    The receptor-type protein tyrosine phosphatase CD45 promotes onset and severity of IL-1beta-mediated autoinflammatory osteomyelitis.
    J Biol Chem. 2021;297:101131.
    >> Share

  57. SCHMIDT CA, Fisher-Wellman KH, Neufer PD
    From OCR and ECAR to energy: Perspectives on the design and interpretation of bioenergetics studies.
    J Biol Chem. 2021;297:101140.
    >> Share


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