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J Biol Chem
    March 2024
  1. LI L, Yao Y, Wang Y, Cao J, et al
    G protein-coupled estrogen receptor 1 ameliorates nonalcoholic steatohepatitis through targeting AMPK-dependent signaling.
    J Biol Chem. 2024;300:105661.
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    February 2024
  2. XU J, Zhang D, Ma Y, Du H, et al
    ROS in diabetic atria regulate SK2 degradation by Atrogin-1 through the NF-kappaB signaling pathway.
    J Biol Chem. 2024 Feb 7:105735. doi: 10.1016/j.jbc.2024.105735.
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    January 2024
  3. CHAUDHARY S, Pahwa F, Nanda RK
    Dysregulated cysteine metabolism leads to worsened liver pathology in diabetes-tuberculosis comorbid conditions.
    J Biol Chem. 2024 Jan 8:105634. doi: 10.1016/j.jbc.2024.105634.
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    December 2023
  4. KELLY CJ, Verdegaal AA, Anderson BW, Shaw WL, et al
    Metformin inhibits digestive proteases and impairs protein digestion in mice.
    J Biol Chem. 2023;299:105363.
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  5. USMAN TO, Chhetri G, Yeh H, Dong HH, et al
    Beta-cell compensation and gestational diabetes.
    J Biol Chem. 2023;299:105405.
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    November 2023
  6. WANG CH, Surbhi S, Goraya S, Byun J, et al
    Fatty acids and inflammatory stimuli induce expression of long-chain acyl-CoA synthetase 1 to promote lipid remodeling in diabetic kidney disease.
    J Biol Chem. 2023 Nov 26:105502. doi: 10.1016/j.jbc.2023.105502.
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  7. DUANGKUMPHA K, Jariyasopit N, Wanichthanarak K, Dhakal E, et al
    Correction: GC x GC-TOFMS metabolomics analysis identifies elevated levels of plasma sugars and sugar alcohols in diabetic mellitus patients with kidney failure.
    J Biol Chem. 2023;299:105422.
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  8. CRAWFORD SA, Groegler J, Dang M, Michel C, et al
    Hybrid insulin peptide isomers spontaneously form in pancreatic beta-cells from an aspartic anhydride intermediate.
    J Biol Chem. 2023;299:105264.
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    August 2023
  9. LI L, Long J, Mise K, Poungavrin N, et al
    The Transcription Factor ChREBP Links Mitochondrial Lipidomes to Mitochondrial Morphology and Progression of Diabetic Kidney Disease.
    J Biol Chem. 2023 Aug 21:105185. doi: 10.1016/j.jbc.2023.105185.
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  10. LI L, Wang H, Pang S, Wang L, et al
    rhFGF-21 accelerates corneal epithelial wound healing through the attenuation of oxidative stress and inflammatory mediators in diabetic mice.
    J Biol Chem. 2023 Aug 4:105127. doi: 10.1016/j.jbc.2023.105127.
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  11. ZHANG IX, Herrmann A, Leon J, Jeyarajan S, et al
    ER stress increases expression of intracellular calcium channel RyR1 to modify Ca(2+) homeostasis in pancreatic beta cells.
    J Biol Chem. 2023;299:105065.
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    July 2023
  12. MYAKALA K, Wang XX, Shults NV, Krawczyk E, et al
    NAD metabolism modulates inflammation and mitochondria function in diabetic kidney disease.
    J Biol Chem. 2023 Jul 8:104975. doi: 10.1016/j.jbc.2023.104975.
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    June 2023
  13. WANG AJ, Ren J, Wang A, Hascall VC, et al
    Monocyte Adhesive Hyaluronan Matrix Induced by Hyperglycemia in Diabetic Lung Injuries.
    J Biol Chem. 2023 Jun 30:104995. doi: 10.1016/j.jbc.2023.104995.
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  14. SUNILKUMAR S, VanCleave AM, McCurry CM, Toro AL, et al
    REDD1-dependent GSK3beta dephosphorylation promotes NF-kappaB activation and macrophage infiltration in the retina of diabetic mice.
    J Biol Chem. 2023 Jun 29:104991. doi: 10.1016/j.jbc.2023.104991.
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  15. BANDET CL, Tan-Chen S, Ali-Berrada S, Campana M, et al
    Ceramide analog C2-cer induces a loss in insulin sensitivity in muscle cells through the salvage/recycling pathway.
    J Biol Chem. 2023;299:104815.
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  16. KOLLERITSCH S, Pajed L, Tilp A, Hois V, et al
    Adverse cardiac remodeling augments adipose tissue ss-adrenergic signaling and lipolysis counteracting diet-induced obesity.
    J Biol Chem. 2023;299:104788.
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    May 2023
  17. TRIEGER GW, Pessentheiner AR, Purcell SC, Green CR, et al
    Glycocalyx engineering with heparan sulfate mimetics attenuates Wnt activity during adipogenesis to promote glucose uptake and metabolism.
    J Biol Chem. 2023;299:104611.
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    April 2023
  18. WANG H, Yuan YC, Chang C, Izumi T, et al
    The signaling protein GIV/Girdin mediates the Nephrin-dependent insulin secretion of pancreatic islet beta cells in response to high glucose.
    J Biol Chem. 2023;299:103045.
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  19. LIU J, Offei SD, Yoshimoto FK, Scott EE, et al
    Pyridine-containing substrate analogs are restricted from accessing the human cytochrome P450 8B1 active site by tryptophan 281.
    J Biol Chem. 2023;299:103032.
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    March 2023
  20. LIU S, Kormos BL, Knafels JD, Sahasrabudhe PV, et al
    Structural studies identify angiotensin II receptor blocker-like compounds as branched-chain ketoacid dehydrogenase kinase inhibitors.
    J Biol Chem. 2023;299:102959.
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    February 2023
  21. YAO H, Wang Y, Zhang X, Li P, et al
    Targeting peroxisomal fatty acid oxidation improves hepatic steatosis and insulin resistance in obese mice.
    J Biol Chem. 2023;299:102845.
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    January 2023
  22. BAEK J, Sas K, He C, Nair V, et al
    The Deacylase Sirtuin 5 Reduces Malonylation in Non-mitochondrial Metabolic Pathways in Diabetic Kidney Disease.
    J Biol Chem. 2023 Jan 31:102960. doi: 10.1016/j.jbc.2023.102960.
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    December 2022
  23. PARK S, Oh S, Kim EK
    Glucagon-like peptide-1 analog liraglutide leads to multiple metabolic alterations in diet-induced obese mice.
    J Biol Chem. 2022;298:102682.
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    November 2022
  24. CHEN Y, Li M, Yang Y, Lu Y, et al
    Anti-diabetic drug metformin suppresses tumorigenesis through inhibition of mevalonate pathway enzyme HMGCS1.
    J Biol Chem. 2022 Nov 7:102678. doi: 10.1016/j.jbc.2022.102678.
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  25. WANG XX, Xie C, Libby AE, Ranjit S, et al
    The role of FXR and TGR5 in reversing and preventing progression of Western diet-induced hepatic steatosis, inflammation, and fibrosis in mice.
    J Biol Chem. 2022;298:102530.
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    October 2022
  26. SUNILKUMAR S, Toro AL, McCurry CF, VanCleave AM, et al
    Stress response protein REDD1 promotes diabetes-induced retinal inflammation by sustaining canonical NF-kappaB signaling.
    J Biol Chem. 2022 Oct 26:102638. doi: 10.1016/j.jbc.2022.102638.
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  27. ZHOU Y, Li ZL, Ding L, Zhang XJ, et al
    Long non-coding RNA SNHG5 promotes podocyte injury via the microRNA-26a-5p/TRPC6 pathway in diabetic nephropathy.
    J Biol Chem. 2022 Oct 15:102605. doi: 10.1016/j.jbc.2022.102605.
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  28. VARNEY MJ, Steyaert W, Coucke PJ, Delanghe JR, et al
    G protein-coupled receptor kinase 6 (GRK6) regulates insulin processing and secretion via effects on proinsulin conversion to insulin.
    J Biol Chem. 2022;298:102421.
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  29. YENILMEZ B, Kelly M, Zhang GF, Wetoska N, et al
    Paradoxical activation of transcription factor SREBP1c and de novo lipogenesis by hepatocyte-selective ATP-citrate lyase depletion in obese mice.
    J Biol Chem. 2022;298:102401.
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    September 2022
  30. PEDERSEN SS, Prause M, Williams K, Barres R, et al
    Butyrate inhibits IL-1beta-induced inflammatory gene expression by suppression of NF-kappaB activity in pancreatic beta cells.
    J Biol Chem. 2022;298:102312.
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  31. DAS F, Ghosh-Choudhury N, Maity S, Kasinath BS, et al
    Oncoprotein DJ-1 interacts with mTOR complexes to effect transcription factor Hif1alpha-dependent expression of collagen I (alpha2) during renal fibrosis.
    J Biol Chem. 2022;298:102246.
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    August 2022
  32. DUANGKUMPHA K, Jariyasopit N, Wanichthanarak K, Dhakal E, et al
    GCxGC-TOFMS Metabolomics Analysis Identifies Elevated Levels of Plasma Sugars and Sugar Alcohols in Diabetic Mellitus Patients with Kidney Failure.
    J Biol Chem. 2022 Aug 30:102445. doi: 10.1016/j.jbc.2022.102445.
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  33. LIU J, Carlson HA, Scott EE
    The structure and characterization of human cytochrome P450 8B1 supports future drug design for non-alcoholic fatty liver disease and diabetes.
    J Biol Chem. 2022 Aug 6:102344. doi: 10.1016/j.jbc.2022.102344.
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    May 2022
  34. GIRDHAR K, Thakur S, Gaur P, Choubey A, et al
    Design, synthesis, and biological evaluation of a small molecule oral agonist of the glucagon-like-peptide-1 receptor.
    J Biol Chem. 2022;298:101889.
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  35. SANDERS MJ, Ratinaud Y, Neopane K, Bonhoure N, et al
    Natural (dihydro)phenanthrene plant compounds are direct activators of AMPK through its allosteric drug and metabolite-binding site.
    J Biol Chem. 2022;298:101852.
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    April 2022
  36. ZHONG X, Wang T, Zhang W, Wang M, et al
    ERK/RSK-mediated phosphorylation of Y-box binding protein-1 aggravates diabetic cardiomyopathy by suppressing its interaction with deubiquitinase OTUB1.
    J Biol Chem. 2022 Apr 28:101989. doi: 10.1016/j.jbc.2022.101989.
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  37. CAI H, Wang X, Zhang Z, Chen J, et al
    Moderate l-lactate administration suppresses adipose tissue macrophage M1 polarization to alleviate obesity-associated insulin resistance.
    J Biol Chem. 2022;298:101768.
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  38. RAHIM M, Nakhe AY, Banerjee DR, Overway EM, et al
    Glucose-6-phosphatase catalytic subunit 2 negatively regulates glucose oxidation and insulin secretion in pancreatic beta-cells.
    J Biol Chem. 2022;298:101729.
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    March 2022
  39. KIND L, Raasakka A, Molnes J, Aukrust I, et al
    Structural and biophysical characterization of transcription factor HNF-1A as a tool to study MODY3 diabetes variants.
    J Biol Chem. 2022 Mar 4:101803. doi: 10.1016/j.jbc.2022.101803.
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  40. VERMA G, Bowen A, Gheibi S, Hamilton A, et al
    Ribosomal biogenesis regulator DIMT1 controls beta-cell protein synthesis, mitochondrial function, and insulin secretion.
    J Biol Chem. 2022;298:101692.
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  41. BLANDINO-ROSANO M, Romaguera Llacer P, Lin A, Reddy JK, et al
    Trimethylguanosine synthase 1 is a novel regulator of pancreatic beta-cell mass and function.
    J Biol Chem. 2022;298:101592.
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    February 2022
  42. GUAN G, Xie J, Dai Y, Han H, et al
    TFPI2 suppresses the interaction of TGF-beta2 pathway regulators to promote endothelial-mesenchymal transition in diabetic nephropathy.
    J Biol Chem. 2022 Feb 11:101725. doi: 10.1016/j.jbc.2022.101725.
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  43. WANG Y, Zhang X, Yao H, Chen X, et al
    Peroxisome-generated succinate induces lipid accumulation and oxidative stress in the kidneys of diabetic mice.
    J Biol Chem. 2022 Feb 3:101660. doi: 10.1016/j.jbc.2022.101660.
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  44. WANG X, Yang Y, Zhao D, Zhang S, et al
    Inhibition of high-fat diet-induced obesity via reduction of ER-resident protein Nogo occurs through multiple mechanisms.
    J Biol Chem. 2022;298:101561.
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  45. HODGES WT, Jarasvaraparn C, Ferguson D, Griffett K, et al
    Mitochondrial pyruvate carrier inhibitors improve metabolic parameters in diet-induced obese mice.
    J Biol Chem. 2022;298:101554.
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  46. DOU X, Zhou WY, Ding M, Ma YJ, et al
    The protease SENP2 controls hepatic gluconeogenesis by regulating the SUMOylation of the fuel sensor AMPKalpha.
    J Biol Chem. 2022;298:101544.
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  47. CABRERA O, Ficorilli J, Shaw J, Echeverri F, et al
    Intra-islet glucagon confers beta-cell glucose competence for first-phase insulin secretion and favors GLP-1R stimulation by exogenous glucagon.
    J Biol Chem. 2022;298:101484.
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    January 2022
  48. ZHANG X, Wang Y, Yao H, Deng S, et al
    Peroxisomal beta-oxidation stimulates cholesterol biosynthesis in the liver in diabetic mice.
    J Biol Chem. 2022 Jan 7:101572. doi: 10.1016/j.jbc.2022.101572.
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  49. REILLY AM, Yan S, Huang M, Abhyankar SD, et al
    A high-fat diet catalyzes progression to hyperglycemia in mice with selective impairment of insulin action in Glut4-expressing tissues.
    J Biol Chem. 2022;298:101431.
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    November 2021
  50. VAN LIEMPD S, Cabrera D, Pilzner C, Kollmus H, et al
    Impaired beta-oxidation increases vulnerability to influenza A infection.
    J Biol Chem. 2021;297:101298.
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    October 2021
    The "Levine effect" and the father of modern diabetes research.
    J Biol Chem. 2021 Oct 27:101356. doi: 10.1016/j.jbc.2021.101356.
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  52. JIN D, Wek SA, Kudlapur NT, Cantara WA, et al
    Disease-associated mutations in a bifunctional aminoacyl-tRNA synthetase gene elicit the integrated stress response.
    J Biol Chem. 2021;297:101203.
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  53. KRALOVA J, Pavliuchenko N, Fabisik M, Ilievova K, et al
    The receptor-type protein tyrosine phosphatase CD45 promotes onset and severity of IL-1beta-mediated autoinflammatory osteomyelitis.
    J Biol Chem. 2021;297:101131.
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  54. SCHMIDT CA, Fisher-Wellman KH, Neufer PD
    From OCR and ECAR to energy: Perspectives on the design and interpretation of bioenergetics studies.
    J Biol Chem. 2021;297:101140.
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