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J Biol Chem
    July 2021
  1. HE X, Gao F, Hou J, Li T, et al
    Metformin inhibits MAPK signaling and rescues pancreatic Aquaporin 7 expression to induce insulin secretion in type 2 diabetes mellitus.
    J Biol Chem. 2021 Jul 22:101002. doi: 10.1016/j.jbc.2021.101002.
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    May 2021
  2. GE W, Zhao Y, Yang Y, Ding Z, et al
    An insulin-independent mechanism for transcriptional regulation of Foxo1 in type 2 diabetic mice.
    J Biol Chem. 2021 May 28:100846. doi: 10.1016/j.jbc.2021.100846.
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  3. AMDARE N, Purcell AW, DiLorenzo TP
    Non-contiguous T cell epitopes in autoimmune diabetes: From mice to men and back again.
    J Biol Chem. 2021 May 24:100827. doi: 10.1016/j.jbc.2021.100827.
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  4. YE J, Stefan-Lifshitz M, Tomer Y
    Genetic and environmental factors regulate the type 1 diabetes gene CTSH via differential DNA methylation.
    J Biol Chem. 2021 May 13:100774. doi: 10.1016/j.jbc.2021.100774.
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  5. KOMENO M, Pang X, Shimizu A, Molla MR, et al
    Cardio- and reno-protective effects of dipeptidyl peptidase III in diabetic mice.
    J Biol Chem. 2021 May 7:100761. doi: 10.1016/j.jbc.2021.100761.
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    April 2021
  6. CHEN Y, Hu W, Li Q, Zhao S, et al
    NGBR is required to ameliorate type 2 diabetes in mice by enhancing insulin sensitivity.
    J Biol Chem. 2021 Apr 1:100624. doi: 10.1016/j.jbc.2021.100624.
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    March 2021
  7. LOPEZ-SOLDADO I, Guinovart JJ, Duran J
    Increasing hepatic glycogen moderates the diabetic phenotype in insulin-deficient Akita mice.
    J Biol Chem. 2021 Mar 2:100498. doi: 10.1016/j.jbc.2021.100498.
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    January 2021
  8. KLYUYEVA AV, Belyaeva OV, Goggans KR, Krezel W, et al
    Changes in retinoid metabolism and signaling associated with metabolic remodeling during fasting and in type I diabetes.
    J Biol Chem. 2021 Jan 21:100323. doi: 10.1016/j.jbc.2021.100323.
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  9. JIANG Y, Luo W, Wang B, Yi Z, et al
    1alpha,25-Dihydroxyvitamin D3 ameliorates diabetes-induced bone loss by attenuating FoxO1-mediated autophagy.
    J Biol Chem. 2021 Jan 12:100287. doi: 10.1016/j.jbc.2021.100287.
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    December 2020
  10. VAN DIERENDONCK XAMH, Sancerni T, Alves-Guerra MC, Stienstra R, et al
    The role of uncoupling protein 2 in macrophages and its impact on obesity-induced adipose tissue inflammation and insulin resistance.
    J Biol Chem. 2020;295:17535-17548.
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  11. COCHRANE VA, Wu Y, Yang Z, ElSheikh A, et al
    Leptin modulates pancreatic beta-cell membrane potential through Src kinase-mediated phosphorylation of NMDA receptors.
    J Biol Chem. 2020;295:17281-17297.
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    November 2020
  12. SCHAID MD, Green CL, Peter DC, Gallagher SJ, et al
    Agonist-independent Galphaz activity negatively regulates beta-cell compensation in a diet-induced obesity model of type 2 diabetes.
    J Biol Chem. 2020 Nov 10. pii: RA120.015585. doi: 10.1074/jbc.RA120.015585.
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  13. PARANDEH F, Amisten S, Verma G, Mohammed Al-Amily I, et al
    Inhibitory effect of UDP-glucose on cAMP generation and insulin secretion.
    J Biol Chem. 2020;295:15245-15252.
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    October 2020
  14. SHAH AM, Wondisford FE
    Tracking the carbons supplying gluconeogenesis.
    J Biol Chem. 2020;295:14419-14429.
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  15. PERRY RJ, Shulman GI
    Sodium-glucose cotransporter-2 inhibitors: Understanding the mechanisms for therapeutic promise and persisting risks.
    J Biol Chem. 2020;295:14379-14390.
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  16. MAITY S, Das F, Kasinath BS, Ghosh-Choudhury N, et al
    TGFbeta acts through PDGFRbeta to activate mTORC1 via the Akt/PRAS40 axis and causes glomerular mesangial cell hypertrophy and matrix protein expression.
    J Biol Chem. 2020;295:14262-14278.
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    June 2020
  17. DUAN Y, Luo Q, Wang Y, Ma Y, et al
    Adipose mesenchymal stem cell-derived extracellular vesicles containing microRNA-26a-5p target TLR4 and protect against diabetic nephropathy.
    J Biol Chem. 2020 Jun 24. pii: RA120.012522. doi: 10.1074/jbc.RA120.012522.
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    May 2020
  18. DIERSCKE SK, Toro AL, Miller WP, Sunilkumar S, et al
    Diabetes enhances translation of Cd40 mRNA in murine retinal Muller glia via a 4E-BP1/2-dependent mechanism.
    J Biol Chem. 2020 May 31. pii: RA120.013711. doi: 10.1074/jbc.RA120.013711.
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  19. MILLER WP, Sunilkumar S, Giordano JF, Toro AL, et al
    The stress response protein REDD1 promotes diabetes-induced oxidative stress in the retina by Keap1-independent Nrf2 degradation.
    J Biol Chem. 2020;295:7350-7361.
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  20. MIYAMOTO S, Zhang G, Hall D, Oates PJ, et al
    Restoring mitochondrial superoxide levels with elamipretide (MTP-131) protects db/db mice against progression of diabetic kidney disease.
    J Biol Chem. 2020;295:7249-7260.
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    April 2020
  21. ZHANG IX, Ren J, Vadrevu S, Raghavan M, et al
    ER stress increases store-operated Ca(2+) entry (SOCE) and augments basal insulin secretion in pancreatic beta cells.
    J Biol Chem. 2020;295:5685-5700.
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  22. MILLER WP, Sunilkumar S, Giordano JF, Toro AL, et al
    The stress response protein REDD1 promotes diabetes-induced oxidative stress in the retina by Keap1-independent Nrf2 degradation.
    J Biol Chem. 2020 Apr 15. pii: RA120.013093. doi: 10.1074/jbc.RA120.013093.
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  23. MIYAMOTO S, Zhang G, Hall D, Oates PJ, et al
    Restoring mitochondrial superoxide levels with elamipretide (MTP-131) protects db/db mice against progression of diabetic kidney disease.
    J Biol Chem. 2020 Apr 10. pii: RA119.011110. doi: 10.1074/jbc.RA119.011110.
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  24. ABBADI A, Loftis J, Wang A, Yu M, et al
    Heparin inhibits proinflammatory and promotes anti-inflammatory macrophage polarization under hyperglycemic stress.
    J Biol Chem. 2020;295:4849-4857.
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  25. DIAZ-CORANGUEZ M, Lin CM, Liebner S, Antonetti DA, et al
    Norrin restores blood-retinal barrier properties after vascular endothelial growth factor-induced permeability.
    J Biol Chem. 2020;295:4647-4660.
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    March 2020
  26. PANG H, Wang X, Zhao S, Xi W, et al
    Loss of the voltage-gated proton channel Hv1 decreases insulin secretion and leads to hyperglycemia and glucose intolerance in mice.
    J Biol Chem. 2020;295:3601-3613.
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  27. REGE NK, Liu M, Dhayalan B, Chen YS, et al
    "Register-shift" insulin analogs uncover constraints of proteotoxicity in protein evolution.
    J Biol Chem. 2020;295:3080-3098.
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    December 2019
  28. SIMON MC, Reinbeck AL, Wessel C, Heindirk J, et al
    Distinct alterations of gut morphology and microbiota characterize accelerated diabetes onset in non-obese diabetic mice.
    J Biol Chem. 2019 Dec 10. pii: RA119.010816. doi: 10.1074/jbc.RA119.010816.
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    October 2019
  29. OHNO RI, Ichimaru K, Tanaka S, Sugawa H, et al
    Glucoselysine is derived from fructose and accumulates in the eye lens of diabetic rats.
    J Biol Chem. 2019 Oct 8. pii: RA119.010744. doi: 10.1074/jbc.RA119.010744.
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    September 2019
  30. NISHAD R, Mukhi D, Tahaseen SV, Mungamuri SK, et al
    Growth hormone induces Notch1 signaling in podocytes and contributes to proteinuria in diabetic nephropathy.
    J Biol Chem. 2019 Sep 11. pii: RA119.008966. doi: 10.1074/jbc.RA119.008966.
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  31. ZOU MH, Kirkpatrick SS, Davis BJ, Nelson JS, et al
    Withdrawal: Activation of the AMP-activated protein kinase by the anti-diabetic drug metformin in vivo : Role of mitochondrial reactive nitrogen species.
    J Biol Chem. 2019;294:13525.
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    August 2019
    Cutting fuel offers new clues in diabetic mystery.
    J Biol Chem. 2019;294:12328-12329.
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    July 2019
  33. JIA Y, Reddy MA, Das S, Oh HJ, et al
    Dysregulation of histone H3 lysine 27 trimethylation in transforming growth factor-beta1 induced gene expression in mesangial cells and diabetic kidney.
    J Biol Chem. 2019 Jul 2. pii: RA119.007575. doi: 10.1074/jbc.RA119.007575.
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    June 2019
  34. SUN L, Pan X, Wada J, Haas CS, et al
    Withdrawal: Isolation and functional analysis of mouse UbA52 gene and its relevance to diabetic nephropathy.
    J Biol Chem. 2019;294:10382.
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  35. SUN L, Dutta RK, Xie P, Kanwar YS, et al
    Withdrawal: myo-Inositol oxygenase overexpression accentuates generation of reactive oxygen species and exacerbates cellular injury following high glucose ambience: A new mechanism relevant to the pathogenesis of diabetic nephropathy.
    J Biol Chem. 2019;294:10380.
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  36. Expression of Concern: Activation of the AMP-activated protein kinase by the anti-diabetic drug metformin in vivo: Role of mitochondrial reactive nitrogen species.
    J Biol Chem. 2019;294:10024.
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  37. LI Y, Cooper A, Odibo IN, Ahmed A, et al
    Withdrawal: Discrepancy in insulin regulation between gestational diabetes mellitus (GDM) platelets and placenta.
    J Biol Chem. 2019;294:9656.
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    May 2019
  38. LI Y, Deng S, Peng J, Wang X, et al
    MicroRNA-223 is essential for maintaining functional beta-cell mass during diabetes through inhibiting both FOXO1 and SOX6 pathways.
    J Biol Chem. 2019 May 22. pii: RA119.007755. doi: 10.1074/jbc.RA119.007755.
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  39. CORSA CAS, Pearson GL, Renberg A, Askar MM, et al
    The E3 ubiquitin ligase parkin is dispensable for metabolic homeostasis in murine pancreatic beta cells and adipocytes.
    J Biol Chem. 2019;294:7296-7307.
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    April 2019
    The mystery of metformin.
    J Biol Chem. 2019;294:6689-6691.
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  41. DONG X, Yu S, Wang Y, Yang M, et al
    (Pro)renin receptor-mediated myocardial injury, apoptosis, and inflammatory response in rats with diabetic cardiomyopathy.
    J Biol Chem. 2019 Apr 5. pii: RA119.007648. doi: 10.1074/jbc.RA119.007648.
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  42. DIERSCHKE SK, Miller WP, Favate JS, Shah P, et al
    O-GlcNAcylation alters the selection of mRNAs for translation and promotes 4E-BP1-dependent mitochondrial dysfunction in the retina.
    J Biol Chem. 2019;294:5508-5520.
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    March 2019
  43. LI Y, Cooper A, Odibo IN, Ahmed A, et al
    Expression of Concern: Discrepancy in insulin regulation between gestational diabetes mellitus (GDM) platelets and placenta.
    J Biol Chem. 2019;294:5208.
    >> Share

  44. CLOSE AF, Dadheech N, Villela BS, Rouillard C, et al
    The orphan nuclear receptor Nor1/Nr4a3 is a negative regulator of beta-cell mass.
    J Biol Chem. 2019;294:4889-4897.
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  45. VAN KRIEKEN R, Mehta N, Wang T, Zheng M, et al
    Cell surface expression of 78 kDa glucose regulated protein (GRP78) mediates diabetic nephropathy.
    J Biol Chem. 2019 Mar 26. pii: RA118.006939. doi: 10.1074/jbc.RA118.006939.
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    February 2019
  46. HART GW
    Nutrient regulation of signaling and transcription.
    J Biol Chem. 2019;294:2211-2231.
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    January 2019
  47. MICHAEL ES, Covic L, Kuliopulos A
    TAAR1 promotes anti-diabetic signaling in insulin-secreting cells.
    J Biol Chem. 2019 Jan 22. pii: RA118.005464. doi: 10.1074/jbc.RA118.005464.
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  48. LING TY, Yi F, Lu T, Wang XL, et al
    F-box protein-32 down-regulates small-conductance calcium-activated potassium channel 2 in diabetic mouse atria.
    J Biol Chem. 2019 Jan 11. pii: RA118.003837. doi: 10.1074/jbc.RA118.003837.
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  49. YAMAMOTO WR, Bone RN, Sohn P, Syed F, et al
    Endoplasmic reticulum stress alters ryanodine receptor function in the murine pancreatic beta cell.
    J Biol Chem. 2019;294:168-181.
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    September 2018
  50. WARD MG, Li G, Hao M
    Apoptotic beta-cells induce macrophage reprogramming under diabetic conditions.
    J Biol Chem. 2018 Sep 13. pii: RA118.004565. doi: 10.1074/jbc.RA118.004565.
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    June 2018
  51. KEFALAS G, Jouvet N, Baldwin C, Estall JL, et al
    Peptide-based sequestration of the adaptor protein Nck1 in pancreatic beta cells enhances insulin biogenesis and protects against diabetogenic stresses.
    J Biol Chem. 2018 Jun 25. pii: RA118.002728. doi: 10.1074/jbc.RA118.002728.
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    April 2018
  52. SUAREZ J, Cividini F, Scott BT, Lehmann K, et al
    Restoring mitochondrial calcium uniporter expression in diabetic mouse heart improves mitochondrial calcium handling and cardiac function.
    J Biol Chem. 2018 Apr 6. pii: RA118.002066. doi: 10.1074/jbc.RA118.002066.
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    December 2017
  53. HAHN C, Tyka K, Saba JD, Lenzen S, et al
    Overexpression of sphingosine-1-phosphate lyase protects insulin-secreting cells against cytokine toxicity.
    J Biol Chem. 2017;292:20292-20304.
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    October 2017
  54. KROUT D, Schaar A, Sun Y, Sukumaran P, et al
    The TRPC1 Ca2+-permeable channel inhibits exercise-induced protection against high-fat diet-induced obesity and type II diabetes.
    J Biol Chem. 2017 Oct 26. pii: jbc.M117.809954. doi: 10.1074/jbc.M117.809954.
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  55. XIONG Y, Zhang Y, Xin N, Yuan Y, et al
    1alpha,25-Dihydroxyvitamin D3 promotes bone formation by promoting nuclear exclusion of the FoxO1 transcription factor in diabetic mice.
    J Biol Chem. 2017 Oct 17. pii: jbc.M117.796367. doi: 10.1074/jbc.M117.796367.
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    September 2017
  56. GLINIAK CM, Brown JM, Noy N
    The retinol-binding protein receptor STRA6 regulates diurnal insulin responses.
    J Biol Chem. 2017;292:15080-15093.
    >> Share

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