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Depression
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Articles published in
Proc Natl Acad Sci U S A
    March 2026
  1. PANG C, Sun X, Zhao J, Liang X, et al
    Personalized functional topography-based multisite brain age prediction modeling reveals divergent neurodevelopment in major depression.
    Proc Natl Acad Sci U S A. 2026;123:e2519586123.
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    February 2026
  2. MAHMOOD N, Dang CL, Wu PY, Huang Z, et al
    The ISR downstream effector ATF4 promotes mGluR-dependent long-term depression and associated behavior.
    Proc Natl Acad Sci U S A. 2026;123:e2532796123.
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  3. HU Y, Gruen JR, Zhang H
    Identifying genome-by-childhood trauma interactions for depression using a forest-based approach in the UK Biobank and Adolescent Brain Cognitive Development Study.
    Proc Natl Acad Sci U S A. 2026;123:e2527955123.
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    January 2026
  4. TENGSTEDT ANB, Hoye TT, Kristensen TN, Hansen MM, et al
    Evaluating inbreeding and assessing the risk of outbreeding depression in genetic rescue using whole-genome sequence data.
    Proc Natl Acad Sci U S A. 2026;123:e2526216122.
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    November 2025
  5. HESTEHAVE S, Florea R, Singleton S, Fedorec AJH, et al
    Analgesia through FKBP51 inhibition at disease onset confers lasting relief from sensory and emotional chronic pain symptoms.
    Proc Natl Acad Sci U S A. 2025;122:e2517405122.
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    September 2025
  6. MCCARTHY CI, Zack Ma Z, Monteggia LM, Kavalali ET, et al
    Spontaneous glutamate release activates mGluR signaling to drive rapid antidepressant responses.
    Proc Natl Acad Sci U S A. 2025;122:e2510642122.
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  7. WANG YH, Fu CL, Chen LB, Zhang CY, et al
    Microglia contribute to bipolar depression through Serinc2-dependent phospholipid synthesis.
    Proc Natl Acad Sci U S A. 2025;122:e2500116122.
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  8. LI W, Feng Y, Xu Z, Xu X, et al
    Precise antibody delivery to the brain via nanobubble-actuated focused ultrasound alleviates depression.
    Proc Natl Acad Sci U S A. 2025;122:e2421800122.
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    August 2025

  9. Correction for Mellya et al., Natural dispersal is better than translocation for reducing risks of inbreeding depression in eastern black rhinoceros (Diceros bicornis michaeli).
    Proc Natl Acad Sci U S A. 2025;122:e2519110122.
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    June 2025
  10. MELLYA RVK, Hopcraft JGC, Mwakilema W, Eblate EM, et al
    Natural dispersal is better than translocation for reducing risks of inbreeding depression in eastern black rhinoceros (Diceros bicornis michaeli).
    Proc Natl Acad Sci U S A. 2025;122:e2414412122.
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    May 2025
  11. XIA J, Zou Y, Cui Y, Zhang S, et al
    Physical exercise activates a PVN-NAc oxytocin circuit to relieve stress-induced depressive-like behaviors.
    Proc Natl Acad Sci U S A. 2025;122:e2503675122.
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    April 2025
  12. MILLER BR, Gonzaga-Jauregui C, Brigatti KW, de Jong J, et al
    A rare variant in GPR156 associated with depression in a Mennonite pedigree causes habenula hyperactivity and stress sensitivity in mice.
    Proc Natl Acad Sci U S A. 2025;122:e2404754122.
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    November 2024
  13. DUARTE Y, Quintana-Donoso D, Moraga-Amaro R, Dinamarca I, et al
    The role of astrocytes in depression, its prevention, and treatment by targeting astroglial gliotransmitter release.
    Proc Natl Acad Sci U S A. 2024;121:e2307953121.
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    September 2024
  14. HUR JK, Heffner J, Feng GW, Joormann J, et al
    Language sentiment predicts changes in depressive symptoms.
    Proc Natl Acad Sci U S A. 2024;121:e2321321121.
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  15. MARTINEZ M, Cai T, Yang B, Zhou Z, et al
    Depressive symptoms during the transition to adolescence: Left hippocampal volume as a marker of social context sensitivity.
    Proc Natl Acad Sci U S A. 2024;121:e2321965121.
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    July 2024
  16. PANDEY S, Han W, Li J, Shepard R, et al
    Reversing anxiety by targeting a stress-responsive signaling pathway.
    Proc Natl Acad Sci U S A. 2024;121:e2400078121.
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  17. RAI S, Stade EC, Giorgi S, Francisco A, et al
    Reply to Wang: Clarifying model performance and language markers of depression across races.
    Proc Natl Acad Sci U S A. 2024;121:e2410449121.
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  18. WANG Y
    Large language models for depression prediction.
    Proc Natl Acad Sci U S A. 2024;121:e2409757121.
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  19. PECHEVA D, Smith DM, Casey BJ, Woodward LJ, et al
    Sex and mental health are related to subcortical brain microstructure.
    Proc Natl Acad Sci U S A. 2024;121:e2403212121.
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  20. DE FREITAS J
    Do "Black individuals" really display no linguistic markers of depression?
    Proc Natl Acad Sci U S A. 2024;121:e2410997121.
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  21. RAI S, Stade EC, Giorgi S, Francisco A, et al
    Reply to De Freitas: Social media language explains less of the variance in depression of Black individuals than of White individuals.
    Proc Natl Acad Sci U S A. 2024;121:e2411458121.
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    May 2024
  22. JI S, Guo Y, Yan W, Wei F, et al
    PM(2.5) exposure contributes to anxiety and depression-like behaviors via phenyl-containing compounds interfering with dopamine receptor.
    Proc Natl Acad Sci U S A. 2024;121:e2319595121.
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  23. KNIGHT DJ, Zhang B
    Residential mobility and persistently depressed voting among disadvantaged adults in a large housing experiment.
    Proc Natl Acad Sci U S A. 2024;121:e2306287121.
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  24. LAVANCHY E, Weir BS, Goudet J
    Detecting inbreeding depression in structured populations.
    Proc Natl Acad Sci U S A. 2024;121:e2315780121.
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    April 2024
  25. KUNG CSJ, Steptoe A
    Changes in well-being among socially isolated older people during the COVID-19 pandemic: An outcome-wide analysis.
    Proc Natl Acad Sci U S A. 2024;121:e2308697121.
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  26. RAI S, Stade EC, Giorgi S, Francisco A, et al
    Key language markers of depression on social media depend on race.
    Proc Natl Acad Sci U S A. 2024;121:e2319837121.
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    December 2023
  27. AKIL H, Nestler EJ
    The neurobiology of stress: Vulnerability, resilience, and major depression.
    Proc Natl Acad Sci U S A. 2023;120:e2312662120.
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  28. SHIMO Y, Cathomas F, Lin HY, Chan KL, et al
    Social stress induces autoimmune responses against the brain.
    Proc Natl Acad Sci U S A. 2023;120:e2305778120.
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  29. PAREL ST, Bennett SN, Cheng CJ, Timmermans OC, et al
    Transcriptional signatures of early-life stress and antidepressant treatment efficacy.
    Proc Natl Acad Sci U S A. 2023;120:e2305776120.
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  30. KRYSTAL JH, Kaye AP, Jefferson S, Girgenti MJ, et al
    Ketamine and the neurobiology of depression: Toward next-generation rapid-acting antidepressant treatments.
    Proc Natl Acad Sci U S A. 2023;120:e2305772120.
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  31. TURNER CA, Khalil H, Murphy-Weinberg V, Hagenauer MH, et al
    The impact of COVID-19 on a college freshman sample reveals genetic and nongenetic forms of susceptibility and resilience to stress.
    Proc Natl Acad Sci U S A. 2023;120:e2305779120.
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    November 2023
  32. KELLEY SW, Fisher AJ, Lee CT, Gallagher E, et al
    Elevated emotion network connectivity is associated with fluctuations in depression.
    Proc Natl Acad Sci U S A. 2023;120:e2216499120.
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    October 2023
  33. SEPAHVAND T, Nazari N, Qin T, Rajani V, et al
    Olfactory threat extinction in the piriform cortex: An age-dependent employment of NMDA receptor-dependent long-term depression.
    Proc Natl Acad Sci U S A. 2023;120:e2309986120.
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    June 2023
  34. CHAI Y, Gehrman P, Yu M, Mao T, et al
    Enhanced amygdala-cingulate connectivity associates with better mood in both healthy and depressive individuals after sleep deprivation.
    Proc Natl Acad Sci U S A. 2023;120:e2214505120.
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    May 2023
  35. MITRA A, Raichle ME, Geoly AD, Kratter IH, et al
    Targeted neurostimulation reverses a spatiotemporal biomarker of treatment-resistant depression.
    Proc Natl Acad Sci U S A. 2023;120:e2218958120.
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  36. WANG A, Wan X, Zhuang P, Jia W, et al
    High fried food consumption impacts anxiety and depression due to lipid metabolism disturbance and neuroinflammation.
    Proc Natl Acad Sci U S A. 2023;120:e2221097120.
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    April 2023
  37. HAO Y, Farah MJ
    Heterogeneity of depression across the socioeconomic spectrum.
    Proc Natl Acad Sci U S A. 2023;120:e2222069120.
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