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Depression
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Articles published in
Pharmacol Biochem Behav
    August 2025
  1. FABIO MC, Mujica MV, Fogliatti E, Aguilar MV, et al
    Prenatal serotonin depletion persistently disrupts social behavior and modulates DeltaFosB and SERT expression in mice.
    Pharmacol Biochem Behav. 2025;253:174043.
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    May 2025
  2. AKKAYA A, Aykan D, Gencturk S, Unal G, et al
    Intermittent environmental enrichment induces behavioral despair, while intermittent social isolation impairs spatial learning in rats.
    Pharmacol Biochem Behav. 2025;250:174001.
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  3. DRAGON J, Golyszny M, Obuchowicz E
    Co-treatment with cannabidiol and escitalopram in ineffective doses induces antidepressant effect in maternally separated male adolescent rats.
    Pharmacol Biochem Behav. 2025;250:174000.
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  4. SHI L, He Y, Lian Y, Luo J, et al
    Melanin-concentrating hormone: A promising target for antidepressant treatment.
    Pharmacol Biochem Behav. 2025;250:173999.
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    April 2025
  5. ZHANG W, Ai Z, Zhu G, Yang M, et al
    Drosophila model of depression-like behavior: systematic investigation of external stress parameters and intrinsic susceptibility.
    Pharmacol Biochem Behav. 2025;252:174014.
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    March 2025
  6. BABII Y, Palucha-Poniewiera A, Golembiowska K, Bysiek A, et al
    Coadministration of scopolamine and mGlu2 receptor negative allosteric modulator VU6001966 as a potential therapeutic approach for depression: Rat frontal cortex neurochemistry and behavior.
    Pharmacol Biochem Behav. 2025 Mar 6:173996. doi: 10.1016/j.pbb.2025.173996.
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  7. YANG XY, Wang HQ, Meng-Zhang, Chen AP, et al
    Astrocyte gap junction dysfunction activates JAK2-STAT3 pathway to mediate inflammation in depression.
    Pharmacol Biochem Behav. 2025 Mar 5:173987. doi: 10.1016/j.pbb.2025.173987.
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  8. SHEN Y, Ran W, Liu D, Lv F, et al
    Esketamine-mediated alleviation of electroconvulsive shock-induced memory impairment is associated with the regulation of mGluR5 in depressive-like rats.
    Pharmacol Biochem Behav. 2025;248:173955.
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    February 2025
  9. CHALME RL, Rubin E, Evans SM, Haney M, et al
    Venlafaxine treatment is associated with improved mood, but not decreased cocaine self-administration, in depressed people who use cocaine.
    Pharmacol Biochem Behav. 2025;247:173918.
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  10. CLARK EA, Wang L, Hanania T, Kretschmannova K, et al
    5-HT(1B) receptor activation produces rapid antidepressant-like effects in rodents.
    Pharmacol Biochem Behav. 2025;247:173917.
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    January 2025
  11. ZHU BL, Tang JY, Chen WJ, Qian JJ, et al
    Fluoxetine treatment reverses chronic stress-induced promotion on Fk506-binding protein 5 expression and multiple effects on glucocorticoid receptor phosphorylation in the paraventricular nucleus of mice.
    Pharmacol Biochem Behav. 2025;246:173916.
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  12. BAHI A, Dreyer JL
    Myelin Transcription Factor 1 (MyT1) overexpression mitigates social isolation-induced behavioral deficits: Insights into cortical synaptotagmin 1 regulation and antidepressant-like effects.
    Pharmacol Biochem Behav. 2025;246:173912.
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    December 2024
  13. HARIOM, Kumari P, Chaturvedi S, Shrivastav S, et al
    Caffeic acid differentially modulates behavior and neurochemicals in chronic unpredictable mild stress and dexamethasone induced models of depression.
    Pharmacol Biochem Behav. 2024;247:173930.
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  14. ZHOU L, Wu Z, Li Y, Xiao L, et al
    Perinatal running training reversed postnatal anxiety and depressive-like behavior and cognitive impairment in mice following prenatal subchronic variable stress.
    Pharmacol Biochem Behav. 2024;245:173898.
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  15. SCOTTON E, Ziani PR, Wilges RLB, da Rosa Correa PH, et al
    Molecular signature underlying (R)-ketamine rapid antidepressant response on anhedonic-like behavior induced by sustained exposure to stress.
    Pharmacol Biochem Behav. 2024;245:173882.
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    November 2024
  16. LIU G, Ma L, Sakamoto A, Fujimura L, et al
    Splenic gammadelta T cells mediate antidepressant and prophylactic actions of arketamine in lipopolysaccharide-induced depression in mice.
    Pharmacol Biochem Behav. 2024;245:173906.
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    September 2024
  17. GUO D, Yao Y, Liu X, Han Y, et al
    Clemastine improves emotional and social deficits in adolescent social isolation mice by reversing demyelination.
    Pharmacol Biochem Behav. 2024;242:173824.
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  18. CHEN WJ, Zhu BL, Qian JJ, Zhao J, et al
    Hippocampal SorCS2 overexpression represses chronic stress-induced depressive-like behaviors by promoting the BDNF-TrkB system.
    Pharmacol Biochem Behav. 2024;242:173820.
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  19. CHENG J, Wu C, Wang Y, Wang Z, et al
    The antidepressant-like effect and proposed mechanism of action of TPN672MA, a novel serotonin-dopamine receptor modulator for the treatment of schizophrenia.
    Pharmacol Biochem Behav. 2024;242:173809.
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    August 2024
  20. LIU Y, Zhang L, Fu S, Wei S, et al
    Gender differences in the relationship between nicotine exposure and symptoms of depression.
    Pharmacol Biochem Behav. 2024;244:173857.
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    July 2024
  21. DA SILVA DMA, Sales ISL, Oliveira JVS, Dos Santos Junior MA, et al
    Cyclooxygenase-2 inhibitors alleviated depressive and anxious-like behaviors in mice exposed to lipopolysaccharide: Involvement of oxidative stress and neuroinflammation.
    Pharmacol Biochem Behav. 2024;240:173778.
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    June 2024
  22. SABARATHINAM S
    Deciphering the gut microbiota's (Coprococcus and Subdoligranulum) impact on depression: Network pharmacology and molecular dynamics simulation.
    Pharmacol Biochem Behav. 2024;241:173805.
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  23. YANG Y, Zhou D, Min S, Liu D, et al
    Ciprofol ameliorates ECS-induced learning and memory impairment by modulating aerobic glycolysis in the hippocampus of depressive-like rats.
    Pharmacol Biochem Behav. 2024;239:173775.
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  24. JIANG H, Zhang M, Wang HQ, Zhang NN, et al
    Inflammation and Connexin 43 profiles in the prefrontal cortex are relevant to stress susceptibility and resilience in mice.
    Pharmacol Biochem Behav. 2024;239:173757.
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    May 2024
  25. WEN W, Wenjing Z, Xia X, Duan X, et al
    Efficacy of ketamine versus esketamine in the treatment of perioperative depression: A review.
    Pharmacol Biochem Behav. 2024 May 26:173773. doi: 10.1016/j.pbb.2024.173773.
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  26. MA L, Eguchi A, Liu G, Qu Y, et al
    A role of gut-brain axis on prophylactic actions of arketamine in male mice exposed to chronic restrain stress.
    Pharmacol Biochem Behav. 2024;238:173736.
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    April 2024
  27. ZHENG JY, Li XX, Liu X, Zhang CC, et al
    Fluoxetine reverses early-life stress-induced depressive-like behaviors and region-specific alterations of monoamine transporters in female mice.
    Pharmacol Biochem Behav. 2024;237:173722.
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    March 2024
  28. LI Y, Luo Y, Zhu P, Liang X, et al
    Running exercise improves astrocyte loss, morphological complexity and astrocyte-contacted synapses in the hippocampus of CUS-induced depression model mice.
    Pharmacol Biochem Behav. 2024 Mar 15:173750. doi: 10.1016/j.pbb.2024.173750.
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  29. BEGEGA A, Lopez M, Cuesta-Lopez I, Jove CI, et al
    Physical activity as a promoter of stress resilience: An analysis of behavioral effects and brain connectivity with cytochrome c-oxidase activity in adult male Wistar rats.
    Pharmacol Biochem Behav. 2024;236:173709.
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    February 2024
  30. SHARMA R, Bansal P, Saini L, Sharma N, et al
    Zuranolone, a neuroactive drug, used in the treatment of postpartum depression by modulation of GABA(A) receptors.
    Pharmacol Biochem Behav. 2024 Feb 20:173734. doi: 10.1016/j.pbb.2024.173734.
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    December 2023
  31. BRANDAO AAC, Deus DLS, Duarte-Filho LAMS, Menezes PMN, et al
    Nebulized and intraperitoneal ketamine have equivalent antidepressant-like effect in the forced swim and tail suspension tests in mice.
    Pharmacol Biochem Behav. 2023;233:173674.
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  32. LIU G, Ma L, Qu Y, Wan X, et al
    Prophylactic effects of arketamine, but not hallucinogenic psychedelic DOI nor non-hallucinogenic psychedelic analog lisuride, in lipopolysaccharide-treated mice and mice exposed to chronic restrain stress.
    Pharmacol Biochem Behav. 2023;233:173659.
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    November 2023
  33. HIROSE Y, Oda Y, Yoshino K, Yano F, et al
    Reduction of claudin-5 and aquaporin-4 in the rat hippocampal CA-1 and CA-3 regions of a learned helplessness model of depression.
    Pharmacol Biochem Behav. 2023 Nov 20:173676. doi: 10.1016/j.pbb.2023.173676.
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  34. LIU F, Tian Q, Tang HL, Cheng X, et al
    Hydrogen sulfide attenuates depression-like behaviours in Parkinson's disease model rats by improving synaptic plasticity in a hippocampal Warburg effect-dependent manner.
    Pharmacol Biochem Behav. 2023 Nov 13:173677. doi: 10.1016/j.pbb.2023.173677.
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  35. MAHDIREJEI HA, Peeri M, Azarbayjani MA, Fattahi Masrour F, et al
    Fluoxetine combined with swimming exercise synergistically reduces lipopolysaccharide-induced depressive-like behavior by normalizing the HPA axis and brain inflammation in mice.
    Pharmacol Biochem Behav. 2023;232:173640.
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    September 2023
  36. IBI D, Nakasai G, Sawahata M, Takaba R, et al
    Emotional behaviors as well as the hippocampal reelin expression in C57BL/6N male mice chronically treated with corticosterone.
    Pharmacol Biochem Behav. 2023;230:173617.
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  37. QIN Y, Li H, Zhang Y, Cao JL, et al
    Retigabine promotes ketamine's antidepressant effect in the forced swim test in male and female C57BL/6J mice.
    Pharmacol Biochem Behav. 2023;230:173590.
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    July 2023
  38. ELDER HJ, Walentiny DM, Beardsley PM
    Theophylline reverses oxycodone's but not fentanyl's respiratory depression in mice while caffeine is ineffective against both opioids.
    Pharmacol Biochem Behav. 2023;229:173601.
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    June 2023
  39. WHITE SW, Squires GD, Smith SJ, Wright GM, et al
    Anxiolytic-like effects of an mGluR 5 antagonist and a mGluR 2/3 agonist, and antidepressant-like effects of an mGluR 7 agonist in the chick social separation stress test, a dual-drug screening model of treatment-resistant depression.
    Pharmacol Biochem Behav. 2023 Jun 20:173588. doi: 10.1016/j.pbb.2023.173588.
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    May 2023
  40. VARSHNEYA NB, Hassanien SH, Holt MC, Stevens DL, et al
    Fentanyl analog structure-activity relationships demonstrate determinants of diverging potencies for antinociception and respiratory depression.
    Pharmacol Biochem Behav. 2023;226:173572.
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  41. MEDINA-RODRIGUEZ EM, Cruz AA, De Abreu JC, Beurel E, et al
    Stress, inflammation, microbiome and depression.
    Pharmacol Biochem Behav. 2023 May 4:173561. doi: 10.1016/j.pbb.2023.173561.
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    February 2023
  42. ONISIFOROU A, Georgiou P, Zanos P
    Role of group II metabotropic glutamate receptors in ketamine's antidepressant actions.
    Pharmacol Biochem Behav. 2023;223:173531.
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  43. HERNANDEZ-HERNANDEZ E, Ledesma-Corvi S, Yanez-Gomez F, Garau C, et al
    Sex differences in the antidepressant-like response and molecular events induced by the imidazoline-2 receptor agonist CR4056 in rats.
    Pharmacol Biochem Behav. 2023;223:173527.
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  44. SCOTTON E, Casa PL, de Abreu FP, de Avila E Silva S, et al
    Differentially regulated targets in the fast-acting antidepressant effect of (R)-ketamine: A systems biology approach.
    Pharmacol Biochem Behav. 2023;223:173523.
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