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Depression
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Articles published in
Pharmacol Biochem Behav
    December 2024
  1. ZHOU L, Wu Z, Li Y, Xiao L, et al
    Perinatal running training reversed postnatal anxiety and depressive-like behavior and cognitive impairment in mice following prenatal subchronic variable stress.
    Pharmacol Biochem Behav. 2024;245:173898.
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  2. SCOTTON E, Ziani PR, Wilges RLB, da Rosa Correa PH, et al
    Molecular signature underlying (R)-ketamine rapid antidepressant response on anhedonic-like behavior induced by sustained exposure to stress.
    Pharmacol Biochem Behav. 2024;245:173882.
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    November 2024
  3. LIU G, Ma L, Sakamoto A, Fujimura L, et al
    Splenic gammadelta T cells mediate antidepressant and prophylactic actions of arketamine in lipopolysaccharide-induced depression in mice.
    Pharmacol Biochem Behav. 2024;245:173906.
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    September 2024
  4. GUO D, Yao Y, Liu X, Han Y, et al
    Clemastine improves emotional and social deficits in adolescent social isolation mice by reversing demyelination.
    Pharmacol Biochem Behav. 2024;242:173824.
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  5. CHEN WJ, Zhu BL, Qian JJ, Zhao J, et al
    Hippocampal SorCS2 overexpression represses chronic stress-induced depressive-like behaviors by promoting the BDNF-TrkB system.
    Pharmacol Biochem Behav. 2024;242:173820.
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  6. CHENG J, Wu C, Wang Y, Wang Z, et al
    The antidepressant-like effect and proposed mechanism of action of TPN672MA, a novel serotonin-dopamine receptor modulator for the treatment of schizophrenia.
    Pharmacol Biochem Behav. 2024;242:173809.
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    August 2024
  7. LIU Y, Zhang L, Fu S, Wei S, et al
    Gender differences in the relationship between nicotine exposure and symptoms of depression.
    Pharmacol Biochem Behav. 2024;244:173857.
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    July 2024
  8. DA SILVA DMA, Sales ISL, Oliveira JVS, Dos Santos Junior MA, et al
    Cyclooxygenase-2 inhibitors alleviated depressive and anxious-like behaviors in mice exposed to lipopolysaccharide: Involvement of oxidative stress and neuroinflammation.
    Pharmacol Biochem Behav. 2024;240:173778.
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    June 2024
  9. SABARATHINAM S
    Deciphering the gut microbiota's (Coprococcus and Subdoligranulum) impact on depression: Network pharmacology and molecular dynamics simulation.
    Pharmacol Biochem Behav. 2024;241:173805.
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  10. YANG Y, Zhou D, Min S, Liu D, et al
    Ciprofol ameliorates ECS-induced learning and memory impairment by modulating aerobic glycolysis in the hippocampus of depressive-like rats.
    Pharmacol Biochem Behav. 2024;239:173775.
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  11. JIANG H, Zhang M, Wang HQ, Zhang NN, et al
    Inflammation and Connexin 43 profiles in the prefrontal cortex are relevant to stress susceptibility and resilience in mice.
    Pharmacol Biochem Behav. 2024;239:173757.
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    May 2024
  12. WEN W, Wenjing Z, Xia X, Duan X, et al
    Efficacy of ketamine versus esketamine in the treatment of perioperative depression: A review.
    Pharmacol Biochem Behav. 2024 May 26:173773. doi: 10.1016/j.pbb.2024.173773.
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  13. MA L, Eguchi A, Liu G, Qu Y, et al
    A role of gut-brain axis on prophylactic actions of arketamine in male mice exposed to chronic restrain stress.
    Pharmacol Biochem Behav. 2024;238:173736.
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    April 2024
  14. ZHENG JY, Li XX, Liu X, Zhang CC, et al
    Fluoxetine reverses early-life stress-induced depressive-like behaviors and region-specific alterations of monoamine transporters in female mice.
    Pharmacol Biochem Behav. 2024;237:173722.
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    March 2024
  15. LI Y, Luo Y, Zhu P, Liang X, et al
    Running exercise improves astrocyte loss, morphological complexity and astrocyte-contacted synapses in the hippocampus of CUS-induced depression model mice.
    Pharmacol Biochem Behav. 2024 Mar 15:173750. doi: 10.1016/j.pbb.2024.173750.
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  16. BEGEGA A, Lopez M, Cuesta-Lopez I, Jove CI, et al
    Physical activity as a promoter of stress resilience: An analysis of behavioral effects and brain connectivity with cytochrome c-oxidase activity in adult male Wistar rats.
    Pharmacol Biochem Behav. 2024;236:173709.
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    February 2024
  17. SHARMA R, Bansal P, Saini L, Sharma N, et al
    Zuranolone, a neuroactive drug, used in the treatment of postpartum depression by modulation of GABA(A) receptors.
    Pharmacol Biochem Behav. 2024 Feb 20:173734. doi: 10.1016/j.pbb.2024.173734.
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    December 2023
  18. BRANDAO AAC, Deus DLS, Duarte-Filho LAMS, Menezes PMN, et al
    Nebulized and intraperitoneal ketamine have equivalent antidepressant-like effect in the forced swim and tail suspension tests in mice.
    Pharmacol Biochem Behav. 2023;233:173674.
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  19. LIU G, Ma L, Qu Y, Wan X, et al
    Prophylactic effects of arketamine, but not hallucinogenic psychedelic DOI nor non-hallucinogenic psychedelic analog lisuride, in lipopolysaccharide-treated mice and mice exposed to chronic restrain stress.
    Pharmacol Biochem Behav. 2023;233:173659.
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    November 2023
  20. HIROSE Y, Oda Y, Yoshino K, Yano F, et al
    Reduction of claudin-5 and aquaporin-4 in the rat hippocampal CA-1 and CA-3 regions of a learned helplessness model of depression.
    Pharmacol Biochem Behav. 2023 Nov 20:173676. doi: 10.1016/j.pbb.2023.173676.
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  21. LIU F, Tian Q, Tang HL, Cheng X, et al
    Hydrogen sulfide attenuates depression-like behaviours in Parkinson's disease model rats by improving synaptic plasticity in a hippocampal Warburg effect-dependent manner.
    Pharmacol Biochem Behav. 2023 Nov 13:173677. doi: 10.1016/j.pbb.2023.173677.
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  22. MAHDIREJEI HA, Peeri M, Azarbayjani MA, Fattahi Masrour F, et al
    Fluoxetine combined with swimming exercise synergistically reduces lipopolysaccharide-induced depressive-like behavior by normalizing the HPA axis and brain inflammation in mice.
    Pharmacol Biochem Behav. 2023;232:173640.
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    September 2023
  23. IBI D, Nakasai G, Sawahata M, Takaba R, et al
    Emotional behaviors as well as the hippocampal reelin expression in C57BL/6N male mice chronically treated with corticosterone.
    Pharmacol Biochem Behav. 2023;230:173617.
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  24. QIN Y, Li H, Zhang Y, Cao JL, et al
    Retigabine promotes ketamine's antidepressant effect in the forced swim test in male and female C57BL/6J mice.
    Pharmacol Biochem Behav. 2023;230:173590.
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    July 2023
  25. ELDER HJ, Walentiny DM, Beardsley PM
    Theophylline reverses oxycodone's but not fentanyl's respiratory depression in mice while caffeine is ineffective against both opioids.
    Pharmacol Biochem Behav. 2023;229:173601.
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    June 2023
  26. WHITE SW, Squires GD, Smith SJ, Wright GM, et al
    Anxiolytic-like effects of an mGluR 5 antagonist and a mGluR 2/3 agonist, and antidepressant-like effects of an mGluR 7 agonist in the chick social separation stress test, a dual-drug screening model of treatment-resistant depression.
    Pharmacol Biochem Behav. 2023 Jun 20:173588. doi: 10.1016/j.pbb.2023.173588.
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    May 2023
  27. VARSHNEYA NB, Hassanien SH, Holt MC, Stevens DL, et al
    Fentanyl analog structure-activity relationships demonstrate determinants of diverging potencies for antinociception and respiratory depression.
    Pharmacol Biochem Behav. 2023;226:173572.
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  28. MEDINA-RODRIGUEZ EM, Cruz AA, De Abreu JC, Beurel E, et al
    Stress, inflammation, microbiome and depression.
    Pharmacol Biochem Behav. 2023 May 4:173561. doi: 10.1016/j.pbb.2023.173561.
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    February 2023
  29. ONISIFOROU A, Georgiou P, Zanos P
    Role of group II metabotropic glutamate receptors in ketamine's antidepressant actions.
    Pharmacol Biochem Behav. 2023;223:173531.
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  30. HERNANDEZ-HERNANDEZ E, Ledesma-Corvi S, Yanez-Gomez F, Garau C, et al
    Sex differences in the antidepressant-like response and molecular events induced by the imidazoline-2 receptor agonist CR4056 in rats.
    Pharmacol Biochem Behav. 2023;223:173527.
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  31. SCOTTON E, Casa PL, de Abreu FP, de Avila E Silva S, et al
    Differentially regulated targets in the fast-acting antidepressant effect of (R)-ketamine: A systems biology approach.
    Pharmacol Biochem Behav. 2023;223:173523.
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    December 2022
  32. QU Y, Chang L, Ma L, Wan X, et al
    Rapid antidepressant-like effect of non-hallucinogenic psychedelic analog lisuride, but not hallucinogenic psychedelic DOI, in lipopolysaccharide-treated mice.
    Pharmacol Biochem Behav. 2022;222:173500.
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    October 2022
  33. CARLESSI AS, Botelho MEM, Manosso LM, Borba LA, et al
    Sex differences on the response to antidepressants and psychobiotics following early life stress in rats.
    Pharmacol Biochem Behav. 2022;220:173468.
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  34. PALUCHA-PONIEWIERA A
    The role of mGlu2/3 receptor antagonists in the enhancement of the antidepressant-like effect of ketamine.
    Pharmacol Biochem Behav. 2022;220:173454.
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    September 2022
  35. DE MELO MARTINS GM, Pettersen B, Rubensam G, da Silva JMK, et al
    Physical exercise prevents behavioral alterations in a reserpine-treated zebrafish: A putative depression model.
    Pharmacol Biochem Behav. 2022 Sep 2:173455. doi: 10.1016/j.pbb.2022.173455.
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  36. SAADATI N, Bananej M, Khakpai F, Zarrindast MR, et al
    Synergistic antidepressant effects of citalopram and SB-334867 in the REM sleep-deprived mice: Possible role of BDNF.
    Pharmacol Biochem Behav. 2022;219:173449.
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    August 2022
  37. PU Y, He Y, Zhao X, Zhang Q, et al
    Depression-like behaviors in mouse model of Sjogren's syndrome: A role of gut-microbiota-brain axis.
    Pharmacol Biochem Behav. 2022;219:173448.
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    July 2022
  38. DE ARRUDA CM, Doneda DL, de Oliveira VV, da Silva RAL, et al
    Involvement of kynurenine pathway and N-methyl-d-aspartate receptors in the antidepressant-like effect of vilazodone in the tail suspension test in mice.
    Pharmacol Biochem Behav. 2022;218:173433.
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  39. CAMARGO A, Rodrigues ALS
    Guanosine as a promising target for fast-acting antidepressant responses.
    Pharmacol Biochem Behav. 2022;218:173422.
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    February 2022
  40. D'SOUZA MS, Seeley SL, Emerson N, Rose-Malkamaki MJ, et al
    Attenuation of nicotine-induced rewarding and antidepressant-like effects in male and female mice lacking regulator of G-protein signaling 2.
    Pharmacol Biochem Behav. 2022;213:173338.
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  41. CHEN YM, Lin CH, Lane HY
    Distinctively lower DISC1 mRNA levels in patients with schizophrenia, especially in those with higher positive, negative, and depressive symptoms.
    Pharmacol Biochem Behav. 2022;213:173335.
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    January 2022
  42. DONG C, Tian Z, Fujita Y, Fujita A, et al
    Antidepressant-like actions of the mGlu2/3 receptor antagonist TP0178894 in the chronic social defeat stress model: Comparison with escitalopram.
    Pharmacol Biochem Behav. 2022;212:173316.
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    December 2021
  43. FUREIX C, Trevarthen AC, Finnegan EM, Buckova K, et al
    Do greater levels of in-cage waking inactivity in laboratory mice reflect a spontaneous depression-like symptom? A pharmacological investigation.
    Pharmacol Biochem Behav. 2021;212:173311.
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  44. LEUSSIS MP, Thanos JM, Powers A, Peterson E, et al
    Sex differences in long-term behavioral alterations, especially anxiety, following prenatal fluoxetine exposure in C57BL/6 mice.
    Pharmacol Biochem Behav. 2021;211:173293.
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  45. HARA H, Suzuki A, Kunugi A, Tajima Y, et al
    TAK-653, an AMPA receptor potentiator with minimal agonistic activity, produces an antidepressant-like effect with a favorable safety profile in rats.
    Pharmacol Biochem Behav. 2021;211:173289.
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  46. SUN L, Wang G, Wu Z, Xie Y, et al
    Swimming exercise reduces the vulnerability to stress and contributes to the AKT/GSK3beta/CRMP2 pathway and microtubule dynamics mediated protective effects on neuroplasticity in male C57BL/6 mice.
    Pharmacol Biochem Behav. 2021;211:173285.
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    September 2021
  47. FENG C, Ren Y, Zhou J, Dong Y, et al
    Cross-fostering alleviates depression-like behavior mediated by EAAT2 and SNARE complex in prenatal stress offspring rat.
    Pharmacol Biochem Behav. 2021 Sep 3:173269. doi: 10.1016/j.pbb.2021.173269.
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  48. ZHANG F, Hillhouse TM, Anderson PM, Koppenhaver PO, et al
    Opioid receptor system contributes to the acute and sustained antidepressant-like effects, but not the hyperactivity motor effects of ketamine in mice.
    Pharmacol Biochem Behav. 2021;208:173228.
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    July 2021
  49. WANG Y, Jiang R, Wu Z, Zhou L, et al
    Gut microbiota is involved in the antidepressant-like effect of (S)-norketamine in an inflammation model of depression.
    Pharmacol Biochem Behav. 2021;207:173226.
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    June 2021
  50. ZOLFAGHARI FS, Pirri F, Gauvin E, Peeri M, et al
    Exercise and fluoxetine treatment during adolescence protect against early life stress-induced behavioral abnormalities in adult rats.
    Pharmacol Biochem Behav. 2021;205:173190.
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    May 2021
  51. REDDY BR, Babu NS, Das T, Bhattacharya D, et al
    Proteome profile of telencephalon associates attenuated neurogenesis with chronic stress induced mood disorder phenotypes in zebrafish model.
    Pharmacol Biochem Behav. 2021;204:173170.
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    April 2021
  52. HORMAN T, Ayoub S, Leri F
    Evidence of hypoglycemic anhedonia and modulation by bupropion in rats.
    Pharmacol Biochem Behav. 2021;203:173120.
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    March 2021
  53. WANG XL, Wang DQ, Jiao FC, Ding KM, et al
    Diurnal rhythm disruptions induced by chronic unpredictable stress relate to depression-like behaviors in rats.
    Pharmacol Biochem Behav. 2021 Mar 3:173156. doi: 10.1016/j.pbb.2021.173156.
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  54. GAO TH, Ni RJ, Liu S, Tian Y, et al
    Chronic lithium exposure attenuates ketamine-induced mania-like behavior and c-Fos expression in the forebrain of mice.
    Pharmacol Biochem Behav. 2021;202:173108.
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    February 2021
  55. WANG XL, Wang DQ, Jiao FC, Ding KM, et al
    Retraction notice to "Diurnal rhythm disruptions induced by chronic unpredictable stress relate to depression-like behaviors in rats" [Pharmacol. Biochem. Behav. 194 (2020) 172939].
    Pharmacol Biochem Behav. 2021;203:173130.
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    January 2021
  56. TAFSEER S, Gupta R, Ahmad R, Jain S, et al
    Bupropion monotherapy alters neurotrophic and inflammatory markers in patients of major depressive disorder.
    Pharmacol Biochem Behav. 2021;200:173073.
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    November 2020
  57. LIU R, Wu XM, He X, Wang RZ, et al
    Contribution of DNA methyltransferases to spared nerve injury induced depression partially through epigenetically repressing Bdnf in hippocampus: Reversal by ketamine.
    Pharmacol Biochem Behav. 2020 Nov 24:173079. doi: 10.1016/j.pbb.2020.173079.
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  58. NEIS VB, Moretti M, Rosa PB, Dalsenter YO, et al
    The involvement of PI3K/Akt/mTOR/GSK3beta signaling pathways in the antidepressant-like effect of AZD6765.
    Pharmacol Biochem Behav. 2020;198:173020.
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    October 2020
  59. CHRISSOBOLIS S, Luu A, Waldschmidt R, Yoakum M, et al
    Targeting the renin angiotensin system for the treatment of anxiety and depression.
    Pharmacol Biochem Behav. 2020 Oct 25:173063. doi: 10.1016/j.pbb.2020.173063.
    >> Share

  60. SAAVEDRA JS, Garrett PI, Honeycutt SC, Peterson AM, et al
    Assessment of the rapid and sustained antidepressant-like effects of dextromethorphan in mice.
    Pharmacol Biochem Behav. 2020;197:173003.
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  61. SMAIL MA, Smith BL, Nawreen N, Herman JP, et al
    Differential impact of stress and environmental enrichment on corticolimbic circuits.
    Pharmacol Biochem Behav. 2020;197:172993.
    >> Share

    May 2020
  62. PHAM TH, Defaix C, Nguyen TML, Mendez-David I, et al
    Cortical and raphe GABAA, AMPA receptors and glial GLT-1 glutamate transporter contribute to the sustained antidepressant activity of ketamine.
    Pharmacol Biochem Behav. 2020;192:172913.
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  63. AN Q, Li C, Chen Y, Yang Y, et al
    Scaffold hopping of agomelatine leads to enhanced antidepressant effects by modulation of gut microbiota and host immune responses.
    Pharmacol Biochem Behav. 2020;192:172910.
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    March 2020
  64. WEI Y, Chang L, Hashimoto K
    A historical review of antidepressant effects of ketamine and its enantiomers.
    Pharmacol Biochem Behav. 2020;190:172870.
    >> Share

  65. WITKIN JM
    mGlu2/3 receptor antagonism: A mechanism to induce rapid antidepressant effects without ketamine-associated side-effects.
    Pharmacol Biochem Behav. 2020;190:172854.
    >> Share

  66. LAINIOLA M, Linden AM, Aitta-Aho T
    Behavioral responses of mGluR3-KO mice to the lipopolysaccharide-induced innate inflammatory reaction.
    Pharmacol Biochem Behav. 2020;190:172852.
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    January 2020
  67. DEYAMA S, Duman RS
    Neurotrophic mechanisms underlying the rapid and sustained antidepressant actions of ketamine.
    Pharmacol Biochem Behav. 2020;188:172837.
    >> Share

  68. POLESZAK E, Wosko S, Slawinska K, Wyska E, et al
    Influence of the CB1 and CB2 cannabinoid receptor ligands on the activity of atypical antidepressant drugs in the behavioural tests in mice.
    Pharmacol Biochem Behav. 2020;188:172833.
    >> Share

  69. KATO T, Duman RS
    Rapastinel, a novel glutamatergic agent with ketamine-like antidepressant actions: Convergent mechanisms.
    Pharmacol Biochem Behav. 2020;188:172827.
    >> Share


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