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Articles published in
Life Sci
    November 2025
  1. SHARMA O, Grewal AK, Kumar A, Singh V, et al
    CREB-dependent neurobehavioral alterations via TAAR1 receptor modulation in a chronic unpredictable stress model.
    Life Sci. 2025;381:123978.
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  2. HAMDY A, Sayed RH, El-Yamany MF, Helal GK, et al
    Repurposing of rebamipide as a neuroprotective agent to alleviate letrozole-induced depressive-like behaviors in female rats: Targeting SIRT1/FoxO1/wnt/ beta-catenin, and related ferroptosis pathways.
    Life Sci. 2025;380:123941.
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    October 2025
  3. WANG YC, Chen NH, Wang ZZ
    Connexin 43 hemichannel-mediated ATP release in depression: recent advances and mechanistic insights.
    Life Sci. 2025 Oct 27:124047. doi: 10.1016/j.lfs.2025.124047.
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  4. WANG J, Luo Y, Wang S, Zhou Y, et al
    Gut microbiota and late-life depression: from mechanistic insights to clinical rehabilitation.
    Life Sci. 2025 Oct 21:124041. doi: 10.1016/j.lfs.2025.124041.
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    April 2025
  5. COSTA-FERRO ZSM, Cunha RS, Rossi EA, Loiola EC, et al
    Extracellular vesicles derived from mesenchymal stem cells alleviate depressive-like behavior in a rat model of chronic stress.
    Life Sci. 2025;366-367:123479.
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    March 2025
  6. YU Q, Ye S, Chen M, Sun P, et al
    A novel function for exosomes in depression.
    Life Sci. 2025 Mar 13:123558. doi: 10.1016/j.lfs.2025.123558.
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    February 2025
  7. WANG YF, Chen CY, Lei L, Zhang Y, et al
    Regulation of the microglial polarization for alleviating neuroinflammation in the pathogenesis and therapeutics of major depressive disorder.
    Life Sci. 2025;362:123373.
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    December 2024
  8. LYU Q, Shi LQ, Chen HY, Lu M, et al
    Electroacupuncture combined with NSCs-Exo alters the response of hippocampal neurons in a chronic unpredictable mild stress paradigm in ovx rats.
    Life Sci. 2024;359:123235.
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  9. CORREIA AS, Torrado M, Costa-Coelho T, Carvalho ED, et al
    Brain-derived neurotrophic factor modulation in response to oxidative stress and corticosterone: role of scopolamine and mirtazapine.
    Life Sci. 2024;358:123133.
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    October 2024
  10. PENG YY, Tang C, Wang HY, Ding Y, et al
    p75NTR mediated chronic restraint stress-induced depression-like behaviors in mice via hippocampal mTOR pathway.
    Life Sci. 2024 Oct 28:123175. doi: 10.1016/j.lfs.2024.123175.
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  11. LEI L, Wang YF, Chen CY, Wang YT, et al
    Novel insight into astrocyte-mediated gliotransmission modulates the synaptic plasticity in major depressive disorder.
    Life Sci. 2024;355:122988.
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    August 2024
  12. CHEN CY, Wang YF, Lei L, Zhang Y, et al
    Impacts of microbiota and its metabolites through gut-brain axis on pathophysiology of major depressive disorder.
    Life Sci. 2024;351:122815.
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  13. CHEN CW, Chen HC, She SC, Lai CT, et al
    Levilactobacillus brevis SG031 modulates mood-related behaviors and attenuates stress-related sleep disturbance and autonomic dysfunction via gut microbiota modulation in Wistar-Kyoto rats.
    Life Sci. 2024;351:122804.
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    March 2024
  14. LIU H, Li J, Takahashi S, Toyoda A, et al
    Alpha-glycosyl isoquercitrin alleviates subchronic social defeat stress-induced depression symptoms by modulating the microbiota-gut-brain axis in mice.
    Life Sci. 2024 Mar 13:122561. doi: 10.1016/j.lfs.2024.122561.
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    February 2024
  15. JIN X, Guan W
    Progress in the relationship between GDF11 and depression.
    Life Sci. 2024 Feb 18:122507. doi: 10.1016/j.lfs.2024.122507.
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    January 2024
  16. MA Y, Li SX, Zhou RY, Deng LJ, et al
    Geniposide improves depression-like behavior in prenatal stress male offspring through restoring HPA axis- and glucocorticoid receptor-associated dysfunction.
    Life Sci. 2024 Jan 15:122434. doi: 10.1016/j.lfs.2024.122434.
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    December 2023
  17. LIU F, Huang S, Guo D, Li X, et al
    Deep brain stimulation of ventromedial prefrontal cortex reverses depressive-like behaviors via BDNF/TrkB signaling pathway in rats.
    Life Sci. 2023;334:122222.
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    November 2023
  18. XU HS, Chen Y, Patel A, Wang Z, et al
    Chronic exposure to nanocellulose altered depression-related behaviors in mice on a western diet: The role of immune modulation and the gut microbiome.
    Life Sci. 2023 Nov 8:122259. doi: 10.1016/j.lfs.2023.122259.
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    September 2023
  19. LUO Y, Ali T, Liu Z, Gao R, et al
    EPO prevents neuroinflammation and relieves depression via JAK/STAT signaling.
    Life Sci. 2023 Sep 26:122102. doi: 10.1016/j.lfs.2023.122102.
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    August 2023
  20. ZAKI ES, Sayed RH, Saad MA, El-Yamany MF, et al
    Roflumilast ameliorates ovariectomy-induced depressive-like behavior in rats via activation of AMPK/mTOR/ULK1-dependent autophagy pathway.
    Life Sci. 2023;327:121806.
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  21. SANADGOL N, Feriz AM, Lisboa SF, Joca SRL, et al
    Putative role of glial cells in treatment resistance depression: An updated critical literation review and evaluation of single-nuclei transcriptomics data.
    Life Sci. 2023 Aug 11:122025. doi: 10.1016/j.lfs.2023.122025.
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    June 2023
  22. KUO YY, Tsai HY, Kuo YM, Tzeng SF, et al
    Glibenclamide promotes FGF21 secretion in interscapular BAT and attenuates depression-like behaviors in male mice with HFD-induced obesity.
    Life Sci. 2023;328:121900.
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    May 2023
  23. ADZIC M, Lukic I, Mitic M, Glavonic E, et al
    Contribution of the opioid system to depression and to the therapeutic effects of classical antidepressants and ketamine.
    Life Sci. 2023;326:121803.
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