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Articles published in
Proc Natl Acad Sci U S A
    May 2026
  1. XIAO Z, Xu H, Ma N, Lei L, et al
    A BCG hydrogel enables localized NOD2/STING activation to overcome resistance to immune checkpoint blockade.
    Proc Natl Acad Sci U S A. 2026;123:e2531588123.
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  2. YANG WD, Lu MR, Shen Q, Zhou PH, et al
    Lactylated NAT10 contributes to elesclomol-triggered cuproptosis via the NAT10/ac4C-DLAT-mRNA/DLAT positive feedback loop in CRC.
    Proc Natl Acad Sci U S A. 2026;123:e2501185123.
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    April 2026
  3. HARIPRAKASH JM, Zole E, Feng W, Hao D, et al
    Functional role of small extrachromosomal circular DNA in colorectal cancer.
    Proc Natl Acad Sci U S A. 2026;123:e2523047123.
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    March 2026
  4. LEVINE MS, Li J, Ehrlich LIR, DePinho RA, et al
    Viral mimicry may help explain immunogenic cell death.
    Proc Natl Acad Sci U S A. 2026;123:e2537547123.
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  5. WEBER LI, Timpen LE, Egger-Horschinger AS, Schopf P, et al
    Reactivation of the silenced BASP1 gene suppresses oncogenic WNT signaling in human colorectal cancer cells.
    Proc Natl Acad Sci U S A. 2026;123:e2524159123.
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    February 2026
  6. KUMARI N, Chen X, Baldwin AM, Clemons KI, et al
    Metabolic stress conditions dictate MAPKAPK2-dependent efficiency of MEK1/2 inhibition in colorectal carcinoma.
    Proc Natl Acad Sci U S A. 2026;123:e2505331123.
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    January 2026
  7. GLYKOFRIDIS IE, Dekker M, Stoepker C, van Ravesteyn TW, et al
    An accurate cellular assay to determine pathogenicity of coding and noncoding variants in Lynch syndrome genes.
    Proc Natl Acad Sci U S A. 2026;123:e2517801123.
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    December 2025
  8. WANG Y, Huang ZJ, Yu NN, Liang JZ, et al
    MLKL/retromer axis controls PD-L1 recycling to compromise antitumor immunity during VCP inhibition-induced necroptosis.
    Proc Natl Acad Sci U S A. 2025;122:e2518675122.
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    November 2025

  9. Correction for Hao et al., Synthetical lethality of Werner helicase and mismatch repair deficiency is mediated by p53 and PUMA in colon cancer.
    Proc Natl Acad Sci U S A. 2025;122:e2529649122.
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  10. WANG X, Cramer Z, Leu NA, Monaghan K, et al
    Forward genetic screening in engineered colorectal cancer organoids identifies regulators of metastasis.
    Proc Natl Acad Sci U S A. 2025;122:e2510910122.
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    June 2025
  11. DELANNE-CUMENAL M, Defaye M, Delanne-Cumenal A, Ahmed M, et al
    Neuronal ALKAL2 and its ALK receptor contribute to the development of colitis-associated colorectal cancer.
    Proc Natl Acad Sci U S A. 2025;122:e2500632122.
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  12. IGUCHI E, Takai A, Oe N, Fujii Y, et al
    Epithelial Regnase-1 inhibits colorectal tumor growth by regulating IL-17 signaling via degradation of NFKBIZ mRNA.
    Proc Natl Acad Sci U S A. 2025;122:e2500820122.
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    May 2025
  13. ZHANG Y, Zuo A, Ba Y, Liu S, et al
    Cancer-associated fibroblast-derived SEMA3C facilitates colorectal cancer liver metastasis via NRP2-mediated MAPK activation.
    Proc Natl Acad Sci U S A. 2025;122:e2423077122.
    >> Share

  14. JAUREGI-MIGUEL A, Soderholm S, Weiss T, Nordin A, et al
    The developmental factor TBX3 engages with the Wnt/beta-catenin transcriptional complex in colorectal cancer to regulate metastasis genes.
    Proc Natl Acad Sci U S A. 2025;122:e2419691122.
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    April 2025
  15. XI X, Liu L, Tuano N, Tailhades J, et al
    SRP19 and the protein secretion machinery is a targetable vulnerability in cancers with APC loss.
    Proc Natl Acad Sci U S A. 2025;122:e2409677122.
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  16. HUANG C, Wang L, Zhuo C, Chen W, et al
    ID3 enhances PD-L1 expression by restructuring MYC to promote colorectal cancer immune evasion.
    Proc Natl Acad Sci U S A. 2025;122:e2423490122.
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  17. MARONGIU GL, Fink U, Schopf F, Oder A, et al
    Structural basis for immune cell binding of Fusobacterium nucleatum via the trimeric autotransporter adhesin CbpF.
    Proc Natl Acad Sci U S A. 2025;122:e2418155122.
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    March 2025
  18. JIN J, Zhang R, Li J, Gao F, et al
    The NAE1-mediated neddylation operates as an essential post-translational modification checkpoint for effector CD8(+) T cells.
    Proc Natl Acad Sci U S A. 2025;122:e2424061122.
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    November 2024
  19. DONG X, Sun F, Secaira-Morocho H, Hui A, et al
    The dichotomous roles of microbial-modified bile acids 7-oxo-DCA and isoDCA in intestinal tumorigenesis.
    Proc Natl Acad Sci U S A. 2024;121:e2317596121.
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  20. LI M, Chen X, Qu P, Shao Z, et al
    FBXO22 inhibits colitis and colorectal carcinogenesis by regulating the degradation of the S2448-phosphorylated form of mTOR.
    Proc Natl Acad Sci U S A. 2024;121:e2402035121.
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    October 2024
  21. ZHU Q, Li J, Sun H, Fan Z, et al
    O-GlcNAcylation of enolase 1 serves as a dual regulator of aerobic glycolysis and immune evasion in colorectal cancer.
    Proc Natl Acad Sci U S A. 2024;121:e2408354121.
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  22. ABDULLAYEVA G, Liu H, Liu TC, Simmons A, et al
    Goblet cell differentiation subgroups in colorectal cancer.
    Proc Natl Acad Sci U S A. 2024;121:e2414213121.
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  23. YE WL, Huang L, Yang XQ, Wan S, et al
    TRIM21 induces selective autophagic degradation of c-Myc and sensitizes regorafenib therapy in colorectal cancer.
    Proc Natl Acad Sci U S A. 2024;121:e2406936121.
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  24. FAN L, Liu B, Wang Y, Tang B, et al
    Intestinal Lactobacillus murinus-derived small RNAs target porcine polyamine metabolism.
    Proc Natl Acad Sci U S A. 2024;121:e2413241121.
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    September 2024
  25. ZHANG N, Zhang R, Jiang L, Gao Z, et al
    Inhibition of colorectal cancer in Alzheimer's disease is mediated by gut microbiota via induction of inflammatory tolerance.
    Proc Natl Acad Sci U S A. 2024;121:e2314337121.
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    August 2024
  26. ZINK A, Obermeyer Z, Pierson E
    Race adjustments in clinical algorithms can help correct for racial disparities in data quality.
    Proc Natl Acad Sci U S A. 2024;121:e2402267121.
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    July 2024
  27. BORTEL P, Hagn G, Skos L, Bileck A, et al
    Memory effects of prior subculture may impact the quality of multiomic perturbation profiles.
    Proc Natl Acad Sci U S A. 2024;121:e2313851121.
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    June 2024
  28. HUANG KB, Wang FY, Lu Y, Yang LM, et al
    Cu(II) complex that synergistically potentiates cytotoxicity and an antitumor immune response by targeting cellular redox homeostasis.
    Proc Natl Acad Sci U S A. 2024;121:e2404668121.
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    May 2024
  29. YANG C, Dong X, Sun B, Cao T, et al
    Physical immune escape: Weakened mechanical communication leads to escape of metastatic colorectal carcinoma cells from macrophages.
    Proc Natl Acad Sci U S A. 2024;121:e2322479121.
    >> Share

    March 2024
  30. MICHL J, White B, Monterisi S, Bodmer WF, et al
    Phenotypic screen of sixty-eight colorectal cancer cell lines identifies CEACAM6 and CEACAM5 as markers of acid resistance.
    Proc Natl Acad Sci U S A. 2024;121:e2319055121.
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  31. BONNET V, Maikranz E, Madec M, Vertti-Quintero N, et al
    Cancer-on-a-chip model shows that the adenomatous polyposis coli mutation impairs T cell engagement and killing of cancer spheroids.
    Proc Natl Acad Sci U S A. 2024;121:e2316500121.
    >> Share


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