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Articles published in
Gut
    June 2026
  1. WANG J, Zhou M, Tan B, Shi H, et al
    SPP1(+) macrophages facilitate the differentiation and maturation of regulatory T cells in tumour-draining lymph nodes of colorectal cancer.
    Gut. 2026 Jun 12:gutjnl-2025-337038. doi: 10.1136/gutjnl-2025-337038.
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  2. PALLES C, Freeman-Mills L, Arbe-Barnes E, Feeley N, et al
    Comparison between germline and somatic loss-of-function RNF43 mutations reveals different genotype-phenotype associations and provides insights into the genetic mechanisms of colorectal tumourigenesis.
    Gut. 2026;75:1353-1366.
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  3. HOU Y, Wu H, Zhang Z, Wang J, et al
    Bacteroides intestinalis mediates the sensitivity to irinotecan toxicity via tryptophan catabolites.
    Gut. 2026;75:1322-1337.
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    May 2026
  4. CAI R, Zhan W, Lyu X, Yang X, et al
    PTEN deficiency impairs MHC-I-mediated tumour immunity via NRF2-dependent autophagy in microsatellite stable colorectal cancer.
    Gut. 2026 May 22:gutjnl-2026-338195. doi: 10.1136/gutjnl-2026-338195.
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  5. YANG H, Dungan M, Madhu B, Beyries K, et al
    MAIT cell enrichment in Lynch syndrome is associated with immune surveillance and colorectal cancer risk.
    Gut. 2026 May 19:gutjnl-2025-337343. doi: 10.1136/gutjnl-2025-337343.
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    April 2026
  6. LI X, Xie M, Kang JX, Chen Y, et al
    Bifidobacterium catenulatum boosts anti-PD-1 efficacy in microsatellite stable colorectal cancer via activating CD8(+) T cells.
    Gut. 2026 Apr 9:gutjnl-2025-336025. doi: 10.1136/gutjnl-2025-336025.
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  7. LIU C, Gong J, Luo Z, Lai P, et al
    Gut microbe alleviates stress-related cancer metastasis by oleic acid degradation.
    Gut. 2026;75:968-983.
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    March 2026
  8. AWONIYI M, El Hag M, Hernandez J, Yang Q, et al
    Dysbiotic microbiota trigger colitis-associated colorectal cancer and imprint a distinctive bile acid profile in a PSC-IBD model.
    Gut. 2026 Mar 23:gutjnl-2025-336675. doi: 10.1136/gutjnl-2025-336675.
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  9. JANSSEN KP, Basic M, Bolsega S, Metwaly A, et al
    Extrinsic lipids are absorbed and accumulate in colorectal cancer.
    Gut. 2026 Mar 19:gutjnl-2025-336377. doi: 10.1136/gutjnl-2025-336377.
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    January 2026
  10. LADABAUM U, Font Marimon R, Castells Olivera X, Balaguer F, et al
    Effect of long-term adherence on faecal immunochemical test positivity rate, positive predictive value and detection rate in organised population-based colorectal cancer screening.
    Gut. 2026 Jan 30:gutjnl-2025-336994. doi: 10.1136/gutjnl-2025-336994.
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  11. VIJAY-KUMAR M, Yeoh BS, Gewirtz AT
    Hydroxylation matters! Microbial bile acid metabolism and colorectal cancer.
    Gut. 2026 Jan 28:gutjnl-2025-337583. doi: 10.1136/gutjnl-2025-337583.
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  12. WU CT, Targher G, Byrne CD, Younossi ZM, et al
    Colorectal cancer in metabolic dysfunction-associated steatotic liver disease: an international Delphi consensus statement.
    Gut. 2026 Jan 21:gutjnl-2025-337374. doi: 10.1136/gutjnl-2025-337374.
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    December 2025

  13. Correction: RNA-binding protein RALY reprogrammes mitochondrial metabolism via mediating miRNA processing in colorectal cancer.
    Gut. 2025 Dec 25:gutjnl-2020-320652corr1. doi: 10.1136/gutjnl-2020-320652.
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  14. TAN H, Huang L, Wang J, Huang H, et al
    Parasutterella excrementihominis exacerbates experimental colitis and colitis-associated colorectal cancer via pathogenic NETosis activation.
    Gut. 2025 Dec 25:gutjnl-2025-335887. doi: 10.1136/gutjnl-2025-335887.
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  15. DU M, Wang X, Hang D, Wang F, et al
    Metabolomic pattern of ultraprocessed food intake and its association with colorectal cancer risk.
    Gut. 2025 Dec 24:gutjnl-2025-335618. doi: 10.1136/gutjnl-2025-335618.
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  16. OSSWALD A, Wortmann E, Wylensek D, Kuhls S, et al
    Secondary bile acid production by gut bacteria promotes Western diet-associated colorectal cancer.
    Gut. 2025 Dec 18:gutjnl-2024-332243. doi: 10.1136/gutjnl-2024-332243.
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  17. CHEN Y, Padilla Aponte J, Wang K, Du M, et al
    Comparative risk of high-risk neoplasia after polypectomy among individuals aged below 50 years versus 50 years and older.
    Gut. 2025;75:72-80.
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    November 2025
  18. GRANCHER A, Denis B, Plaine J, Vidal-Sengchanh S, et al
    Does a long time to colonoscopy after a positive faecal immunochemical test result have a deleterious impact on colorectal cancer outcomes? A nationwide cohort study.
    Gut. 2025 Nov 27:gutjnl-2025-336036. doi: 10.1136/gutjnl-2025-336036.
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  19. VAN DER SCHEE L, Albers SC, Didden P, Lacle MM, et al
    Results of endoscopic intermuscular dissection for deep submucosal invasive rectal cancer: a three-year follow-up study.
    Gut. 2025;74:1995-2003.
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    October 2025
  20. STEUP C, Kennel K, Neurath MF, Fichtner-Feigl S, et al
    Current and emerging concepts for systemic treatment of metastatic colorectal cancer.
    Gut. 2025 Oct 5:gutjnl-2025-335412. doi: 10.1136/gutjnl-2025-335412.
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    September 2025
  21. CUI Y, Liu H, Zhang L, Zhang H, et al
    Fructose drives colorectal cancer progression by regulating crosstalk between cancer-associated fibroblasts and tumour cells.
    Gut. 2025 Sep 11:gutjnl-2025-335014. doi: 10.1136/gutjnl-2025-335014.
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  22. RUTTER MD, Ranjan R, Westwood C, Barbour J, et al
    BSG/ACPGBI guidance on the management of colorectal polyps in patients with limited life expectancy.
    Gut. 2025;74:1551-1560.
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  23. BAATRUP G, Bjorsum-Meyer T, Kaalby L, Schelde-Olesen B, et al
    Choice of colon capsule or colonoscopy versus default colonoscopy in FIT positive patients in the Danish screening programme: a parallel group randomised controlled trial.
    Gut. 2025;74:1616-1623.
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    August 2025
  24. FIORI ME
    Gut feeling: extracellular vesicles dictate liver's susceptibility to colorectal cancer metastasis.
    Gut. 2025 Aug 25:gutjnl-2025-336108. doi: 10.1136/gutjnl-2025-336108.
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    July 2025
  25. WANG S, Ye G, Xu X, Lin Y, et al
    Pericyte drives the formation of circulating tumour cell-neutrophil clusters to promote colorectal cancer metastasis.
    Gut. 2025 Jul 23:gutjnl-2024-334618. doi: 10.1136/gutjnl-2024-334618.
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    June 2025
  26. FRAZZONI L, Antonelli G, Pilonis ND, Wisse PHA, et al
    Adenoma detection and subsequent colorectal cancer risk: is the race really over?
    Gut. 2025 Jun 27:gutjnl-2025-335225. doi: 10.1136/gutjnl-2025-335225.
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  27. CAO J, Qin S, Li B, Zhang Z, et al
    Extracellular vesicle-induced lipid dysregulation drives liver premetastatic niche formation in colorectal cancer.
    Gut. 2025 Jun 25:gutjnl-2025-334851. doi: 10.1136/gutjnl-2025-334851.
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  28. DREWS J, Zachaus M, Kleemann T, Schirra J, et al
    Multicentre randomised controlled trial of a self-assembling haemostatic gel to prevent delayed bleeding following endoscopic mucosal resection (PURPLE Trial).
    Gut. 2025;74:1103-1111.
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  29. SOUNDARARAJAN R, Halade G, Yeatman TJ
    Response to the letter to the editor 'revisiting lipid dysregulation in colorectal cancer: critical appraisal of pro-inflammatory bias and therapeutic implications'.
    Gut. 2025 Jun 4:gutjnl-2025-335452. doi: 10.1136/gutjnl-2025-335452.
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  30. ZHANG Y, Song W, Zhou L, Wei S, et al
    Bacteria-metabolite butyrate boosts anti-PD1 efficacy in colorectal cancer patient-derived organoids through activating autologous tumour-infiltrating GNLY (+)CD8(+) T cells.
    Gut. 2025 Jun 1:gutjnl-2025-335306. doi: 10.1136/gutjnl-2025-335306.
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    April 2025
  31. GAUCI JL, Mandarino FV, Kerrison C, Whitfield AM, et al
    Margin thermal ablation eliminates size as a risk factor for recurrence after piecemeal endoscopic mucosal resection of large non-pedunculated colorectal polyps.
    Gut. 2025;74:752-760.
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  32. ROBBINS EC, Wooldrage K, Rutter MD, Veitch AM, et al
    Colorectal cancer incidence after the first surveillance colonoscopy and the need for ongoing surveillance: a retrospective, cohort analysis.
    Gut. 2025 Apr 5:gutjnl-2024-334242. doi: 10.1136/gutjnl-2024-334242.
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  33. ZHU X
    Revisiting lipid dysregulation in colorectal cancer: critical appraisal of pro-inflammatory bias and therapeutic implications.
    Gut. 2025 Apr 2:gutjnl-2025-335153. doi: 10.1136/gutjnl-2025-335153.
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    March 2025
  34. DIGBY J, Nobes J, Strachan JA, McCann R, et al
    Combining faecal haemoglobin, iron deficiency anaemia status and age can improve colorectal cancer risk prediction in patients attending primary care with bowel symptoms: a retrospective observational study.
    Gut. 2025 Mar 26:gutjnl-2024-334248. doi: 10.1136/gutjnl-2024-334248.
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    February 2025
  35. HU M, Xu Y, Wang Y, Huang Z, et al
    Gut microbial-derived N-acetylmuramic acid alleviates colorectal cancer via the AKT1 pathway.
    Gut. 2025 Feb 27:gutjnl-2024-332891. doi: 10.1136/gutjnl-2024-332891.
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    January 2025
  36. AL BAKIR I, Curtius K, Cresswell GD, Grant HE, et al
    Low-coverage whole genome sequencing of low-grade dysplasia strongly predicts advanced neoplasia risk in ulcerative colitis.
    Gut. 2025 Jan 29:gutjnl-2024-333353. doi: 10.1136/gutjnl-2024-333353.
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  37. NAN K, Zhong Z, Yue Y, Shen Y, et al
    Fasting-mimicking diet-enriched Bifidobacterium pseudolongum suppresses colorectal cancer by inducing memory CD8(+) T cells.
    Gut. 2025 Jan 27:gutjnl-2024-333020. doi: 10.1136/gutjnl-2024-333020.
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  38. ZHOU Q, Lei L, Cheng J, Chen J, et al
    Microbiota-induced S100A11-RAGE axis underlies immune evasion in right-sided colon adenomas and is a therapeutic target to boost anti-PD1 efficacy.
    Gut. 2025;74:214-228.
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  39. TE GROEN M, Wijnands AM, den Broeder N, de Jong DJ, et al
    Surveillance in inflammatory bowel disease: white light endoscopy with segmental re-inspection versus dye-based chromoendoscopy - a multi-arm randomised controlled trial (HELIOS).
    Gut. 2025 Jan 16:gutjnl-2024-333446. doi: 10.1136/gutjnl-2024-333446.
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    December 2024
  40. WANG S, Peng F, Dang M, Jiao H, et al
    Early detection of colorectal cancer using aberrant circulating cell-free mitochondrial DNA fragmentomics.
    Gut. 2024 Dec 18:gutjnl-2024-333533. doi: 10.1136/gutjnl-2024-333533.
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  41. SOUNDARARAJAN R, Maurin MM, Rodriguez-Silva J, Upadhyay G, et al
    Integration of lipidomics with targeted, single cell, and spatial transcriptomics defines an unresolved pro-inflammatory state in colon cancer.
    Gut. 2024 Dec 10:gutjnl-2024-332535. doi: 10.1136/gutjnl-2024-332535.
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    November 2024
  42. RAJASEKARAN V, Harris BT, Osborn RT, Smillie C, et al
    Genetic variation at 11q23.1 confers colorectal cancer risk by dysregulation of colonic tuft cell transcriptional activator POU2AF2.
    Gut. 2024 Nov 28:gutjnl-2024-332121. doi: 10.1136/gutjnl-2024-332121.
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  43. SCHWARZMUELLER LJ, Adam RS, Moreno LF, Nijman LE, et al
    Identifying colorectal cancer-specific vulnerabilities in the Wnt-driven long non-coding transcriptome.
    Gut. 2024 Nov 19:gutjnl-2024-332752. doi: 10.1136/gutjnl-2024-332752.
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  44. SINONQUEL P, Eelbode T, Pech O, De Wulf D, et al
    Clinical consequences of computer-aided colorectal polyp detection.
    Gut. 2024;73:1974-1983.
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  45. QU R, Zhang Z, Fu W
    Potential microbial effects on microsatellite instability possibly drive divergence in colorectal cancer immunotherapy responses among different anatomical subsites.
    Gut. 2024 Nov 5:gutjnl-2024-334008. doi: 10.1136/gutjnl-2024-334008.
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    September 2024
  46. POLYCHRONIDIS G, He MM, Vithayathil M, Knudsen MD, et al
    Risk of colorectal neoplasia after removal of conventional adenomas and serrated polyps: a comprehensive evaluation of risk factors and surveillance use.
    Gut. 2024;73:1675-1683.
    >> Share

  47. MANDARINO FV, Medas R, Gauci JL, Kerrison C, et al
    Endoscopic mucosal resection for large non-pedunculated colorectal polyps: staying on track with a safe, effective and cost-efficient technique.
    Gut. 2024;73:e13.
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    August 2024
  48. SU ACY, Ding X, Lau HCH, Kang X, et al
    Lactococcus lactis HkyuLL 10 suppresses colorectal tumourigenesis and restores gut microbiota through its generated alpha-mannosidase.
    Gut. 2024;73:1478-1488.
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  49. CHEN J, Hai Y, Li Y, Wang C, et al
    Colonic multiple polypoidal protrusions: not familial adenomatous polyposis.
    Gut. 2024;73:1430-1463.
    >> Share

  50. DJORDJEVIC J, Cisneros Romero NS, Cascione L, Mele V, et al
    Direct toll-like receptor triggering in colorectal cancer-associated stromal cells elicits immunostimulatory properties leading to enhanced immune cell recruitment.
    Gut. 2024 Aug 8:gutjnl-2023-331759. doi: 10.1136/gutjnl-2023-331759.
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    July 2024
  51. MAO X, Cheung KS, Tan JT, Mak LY, et al
    Optimal glycaemic control and the reduced risk of colorectal adenoma and cancer in patients with diabetes: a population-based cohort study.
    Gut. 2024;73:1313-1320.
    >> Share

    June 2024
  52. IACUCCI M, Santacroce G, Majumder S, Morael J, et al
    Opening the doors of precision medicine: novel tools to assess intestinal barrier in inflammatory bowel disease and colitis-associated neoplasia.
    Gut. 2024 Jun 8:gutjnl-2023-331579. doi: 10.1136/gutjnl-2023-331579.
    >> Share

    May 2024
  53. OULADAN S, Orouji E
    Beyond traditional subtyping: a multilayered genomic perspective on colorectal cancer.
    Gut. 2024 May 15:gutjnl-2024-332325. doi: 10.1136/gutjnl-2024-332325.
    >> Share

    April 2024
  54. MEULEN LWT, Bogie RMM, Siersema PD, Winkens B, et al
    Standardised training for endoscopic mucosal resection of large non-pedunculated colorectal polyps to reduce recurrence (*STAR-LNPCP study): a multicentre cluster randomised trial.
    Gut. 2024;73:741-750.
    >> Share

    March 2024
  55. CHEN S, Xin J, Gu D, Li H, et al
    Smoking-related Lactobacillus and immune cell infiltration in colorectal cancer: evidence from a population-based study.
    Gut. 2024 Mar 18:gutjnl-2023-331865. doi: 10.1136/gutjnl-2023-331865.
    >> Share

    February 2024
  56. ABDELRAHIM M, Siggens K, Iwadate Y, Maeda N, et al
    New AI model for neoplasia detection and characterisation in inflammatory bowel disease.
    Gut. 2024 Feb 23:gutjnl-2023-330718. doi: 10.1136/gutjnl-2023-330718.
    >> Share


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