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Chronic Heart Failure
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Articles published in
N Engl J Med
    August 2026
  1. ZHANG H, Wang Q, Liang M, Chen X, et al
    Pulmonary Denervation for Heart Failure-Related Pulmonary Hypertension.
    N Engl J Med. 2026 Aug 30. doi: 10.1056/NEJMoa2609056.
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  2. HAUSLEITER J, Stocker TJ, Geisler T, Lurz P, et al
    Tricuspid-Valve Intervention in Heart Failure.
    N Engl J Med. 2026 Aug 30. doi: 10.1056/NEJMoa2606934.
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  3. ZIMMERMANN WH, Ensminger S, Kutschka I
    Biologic Ventricular Assist Tissue in Heart Failure. Reply.
    N Engl J Med. 2026;395:828-829.
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  4. EMMERT MY, Schoenrath F, Falk V
    Biologic Ventricular Assist Tissue in Heart Failure.
    N Engl J Med. 2026;395:827-828.
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  5. LAL S
    Biologic Ventricular Assist Tissue in Heart Failure.
    N Engl J Med. 2026;395:827.
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    June 2026
  6. HEERSPINK HJL, Neuen BL, Agarwal R, Cherney DZI, et al
    Finerenone in Persons with Chronic Kidney Disease without Diabetes.
    N Engl J Med. 2026 Jun 4. doi: 10.1056/NEJMoa2604625.
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    May 2026
  7. ZIMMERMANN WH, Ensminger S, Kutschka I, Paitazoglou C, et al
    Stem-Cell-Derived Biologic Ventricular Assist Tissue in Heart Failure.
    N Engl J Med. 2026;394:1991-2001.
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    April 2026
  8. CHELU MG, Poole JE, Ellenbogen KA
    Physiologic Pacing in Heart Failure. Reply.
    N Engl J Med. 2026;394:1766-1767.
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  9. XIONG B, Wu Q, Qu G
    Physiologic Pacing in Heart Failure.
    N Engl J Med. 2026;394:1766.
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  10. CHOI KH, Kang D, Kim W, Doh JH, et al
    Discontinuation of Beta-Blocker Therapy after Myocardial Infarction.
    N Engl J Med. 2026;394:1302-1312.
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    January 2026
  11. CHELU MG, Poole JE, Ellenbogen KA
    Physiologic Pacing in Heart Failure.
    N Engl J Med. 2026;394:367-381.
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  12. BAVENDIEK U, Grosshennig A, Bauersachs J
    Digitoxin in Patients with Heart Failure and Reduced Ejection Fraction. Reply.
    N Engl J Med. 2026;394:98.
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  13. SHAMSULDDIN AB
    Digitoxin in Patients with Heart Failure and Reduced Ejection Fraction.
    N Engl J Med. 2026;394:97.
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  14. CURTAIN JP
    Digitoxin in Patients with Heart Failure and Reduced Ejection Fraction.
    N Engl J Med. 2026;394:97.
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  15. BOULIN M, Cransac-Miet A, Tannenbaum C
    Digitoxin in Patients with Heart Failure and Reduced Ejection Fraction.
    N Engl J Med. 2026;394:96-97.
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  16. HOTHI SS, Lau C, Tan LB
    Digitoxin in Patients with Heart Failure and Reduced Ejection Fraction.
    N Engl J Med. 2026;394:96.
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    November 2025
  17. KRISTENSEN AMD, Rossello X, Atar D, Yndigegn T, et al
    Beta-Blockers after Myocardial Infarction with Normal Ejection Fraction.
    N Engl J Med. 2025 Nov 9. doi: 10.1056/NEJMoa2512686.
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    October 2025
  18. NIJVELDT R, Maeng M, Beijnink CWH, Piek JJ, et al
    Immediate or Deferred Nonculprit-Lesion PCI in Myocardial Infarction.
    N Engl J Med. 2025 Oct 28. doi: 10.1056/NEJMoa2512918.
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  19. LEON MB, Mack MJ, Pibarot P, Hahn RT, et al
    Transcatheter or Surgical Aortic-Valve Replacement in Low-Risk Patients at 7 Years.
    N Engl J Med. 2025 Oct 27. doi: 10.1056/NEJMoa2509766.
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    August 2025
  20. MUNKHAUGEN J, Kristensen AMD, Halvorsen S, Holmager T, et al
    Beta-Blockers after Myocardial Infarction in Patients without Heart Failure.
    N Engl J Med. 2025 Aug 30. doi: 10.1056/NEJMoa2505985.
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  21. IBANEZ B, Latini R, Rossello X, Dominguez-Rodriguez A, et al
    Beta-Blockers after Myocardial Infarction without Reduced Ejection Fraction.
    N Engl J Med. 2025 Aug 30. doi: 10.1056/NEJMoa2504735.
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  22. BAVENDIEK U, Grosshennig A, Schwab J, Berliner D, et al
    Digitoxin in Patients with Heart Failure and Reduced Ejection Fraction.
    N Engl J Med. 2025 Aug 29. doi: 10.1056/NEJMoa2415471.
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  23. JONS C, Zheng C, Winslow UCG, Danielsen EM, et al
    Increasing the Potassium Level in Patients at High Risk for Ventricular Arrhythmias.
    N Engl J Med. 2025 Aug 29. doi: 10.1056/NEJMoa2509542.
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    July 2025
  24. KUCERA JA, Overbey DM, Turek JW
    On-Table Reanimation of a Pediatric Heart from Donation after Circulatory Death.
    N Engl J Med. 2025;393:275-280.
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    April 2025
  25. PACKER M, Kramer CM, Borlaug BA
    Tirzepatide for Heart Failure and Obesity. Reply.
    N Engl J Med. 2025;392:1661-1662.
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  26. ALI MK
    Tirzepatide for Heart Failure and Obesity.
    N Engl J Med. 2025;392:1661.
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  27. MARINE JE, Mandrola J, Prasad V
    Tirzepatide for Heart Failure and Obesity.
    N Engl J Med. 2025;392:1660.
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  28. KRAKAUER JC, Krakauer NY
    Tirzepatide for Heart Failure and Obesity.
    N Engl J Med. 2025;392:1660.
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  29. WAGNER J
    Tirzepatide for Heart Failure and Obesity.
    N Engl J Med. 2025;392:1659-1660.
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    March 2025
  30. RAPOSEIRAS-ROUBIN S, Amat-Santos IJ, Rossello X, Gonzalez Ferreiro R, et al
    Dapagliflozin in Patients Undergoing Transcatheter Aortic-Valve Implantation.
    N Engl J Med. 2025 Mar 29. doi: 10.1056/NEJMoa2500366.
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  31. GREENBERG B, Taylor M, Adler E, Colan S, et al
    Phase 1 Study of AAV9.LAMP2B Gene Therapy in Danon Disease.
    N Engl J Med. 2025;392:972-983.
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    February 2025
  32. ANKER SD, Friede T, Khan MS
    Transcatheter Valve Repair in Heart Failure with Moderate to Severe Mitral Regurgitation. Reply.
    N Engl J Med. 2025;392:725-726.
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  33. MEWTON N, Angoulvant D, Bouleti C
    Transcatheter Valve Repair in Heart Failure with Moderate to Severe Mitral Regurgitation.
    N Engl J Med. 2025;392:723-725.
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  34. KOMAMURA K, Murohara T, Iwase M
    Transcatheter Valve Repair in Heart Failure with Moderate to Severe Mitral Regurgitation.
    N Engl J Med. 2025;392:724.
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  35. ANSELMI A, Garcia-Villareal OA, Redberg R
    Transcatheter Valve Repair in Heart Failure with Moderate to Severe Mitral Regurgitation.
    N Engl J Med. 2025;392:723-724.
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    January 2025
  36. FELKER GM
    Toward a New SUMMIT in Heart Failure with Preserved Ejection Fraction.
    N Engl J Med. 2025;392:505-506.
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  37. SOLOMON SD, Claggett B, McMurray JJV
    Finerenone in Heart Failure with Preserved Ejection Fraction. Reply.
    N Engl J Med. 2025;392:309-310.
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  38. ZHANG J, Zhu B, Liu Y
    Finerenone in Heart Failure with Preserved Ejection Fraction.
    N Engl J Med. 2025;392:309.
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  39. PEDREIRA-BOUZAS J, Pousada-Fonseca A, Sierra-Sanchez JF
    Finerenone in Heart Failure with Preserved Ejection Fraction.
    N Engl J Med. 2025;392:308-309.
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  40. CANNATA A, McDonagh TA
    Heart Failure with Preserved Ejection Fraction.
    N Engl J Med. 2025;392:173-184.
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    November 2024
  41. JOLLY SS, d'Entremont MA, Pitt B, Lee SF, et al
    Routine Spironolactone in Acute Myocardial Infarction.
    N Engl J Med. 2024 Nov 17. doi: 10.1056/NEJMoa2405923.
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  42. PACKER M, Zile MR, Kramer CM, Baum SJ, et al
    Tirzepatide for Heart Failure with Preserved Ejection Fraction and Obesity.
    N Engl J Med. 2024 Nov 16. doi: 10.1056/NEJMoa2410027.
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  43. RUBIN EJ, Leopold J, Morrissey S
    NEJM at AHA - Tirzepatide for Heart Failure with Preserved Ejection Fraction and Obesity.
    N Engl J Med. 2024 Nov 16. doi: 10.1056/NEJMe2414470.
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    October 2024
  44. HAHN RT, Makkar R, Thourani VH, Makar M, et al
    Transcatheter Valve Replacement in Severe Tricuspid Regurgitation.
    N Engl J Med. 2024 Oct 30. doi: 10.1056/NEJMoa2401918.
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  45. MCDONAGH TA
    FINEARTS-HF - The Latest Masterpiece for MRAs in Heart Failure.
    N Engl J Med. 2024;391:1540-1541.
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    September 2024
  46. AGARONNIK ND, Iezzoni LI
    Accessible Weight Scales and Exam Tables - New Federal Regulations.
    N Engl J Med. 2024;391:1077-1079.
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  47. RUBIN EJ, Leopold J, Morrissey S
    NEJM at ESC - Finerenone in Heart Failure for Mildly Reduced or Preserved Ejection Fraction.
    N Engl J Med. 2024 Sep 1. doi: 10.1056/NEJMe2410904.
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  48. SOLOMON SD, McMurray JJV, Vaduganathan M, Claggett B, et al
    Finerenone in Heart Failure with Mildly Reduced or Preserved Ejection Fraction.
    N Engl J Med. 2024 Sep 1. doi: 10.1056/NEJMoa2407107.
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    August 2024
  49. RUBIN EJ, Leopold J, Morrissey S
    NEJM at ESC - Transcatheter Valve Repair in Heart Failure with Moderate to Severe Mitral Regurgitation.
    N Engl J Med. 2024 Aug 31. doi: 10.1056/NEJMe2410896.
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  50. ANKER SD, Friede T, von Bardeleben RS, Butler J, et al
    Transcatheter Valve Repair in Heart Failure with Moderate to Severe Mitral Regurgitation.
    N Engl J Med. 2024 Aug 31. doi: 10.1056/NEJMoa2314328.
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  51. BALDUS S, Doenst T, Pfister R, Gummert J, et al
    Transcatheter Repair versus Mitral-Valve Surgery for Secondary Mitral Regurgitation.
    N Engl J Med. 2024 Aug 31. doi: 10.1056/NEJMoa2408739.
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    July 2024
  52. KOSIBOROD MN, Petrie MC, Borlaug BA
    Semaglutide, Obesity-Related Heart Failure, and Type 2 Diabetes. Reply.
    N Engl J Med. 2024;391:381-382.
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  53. AMMON JP, Jackson CD
    Semaglutide, Obesity-Related Heart Failure, and Type 2 Diabetes.
    N Engl J Med. 2024;391:381.
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  54. WAGNER J
    Semaglutide, Obesity-Related Heart Failure, and Type 2 Diabetes.
    N Engl J Med. 2024;391:380-381.
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  55. COHEN C, Cohen R, Sabouret P
    Semaglutide, Obesity-Related Heart Failure, and Type 2 Diabetes.
    N Engl J Med. 2024;391:380.
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    April 2024
  56. SAPP JL, Sivakumaran S, Tang ASL
    Long-Term Outcomes of Resynchronization-Defibrillation for Heart Failure. Reply.
    N Engl J Med. 2024;390:1343-1345.
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  57. PINTEA BENTEA G, Castro Rodriguez J
    Long-Term Outcomes of Resynchronization-Defibrillation for Heart Failure.
    N Engl J Med. 2024;390:1344.
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  58. BYUN JH, Nguyen S
    Long-Term Outcomes of Resynchronization-Defibrillation for Heart Failure.
    N Engl J Med. 2024;390:1343-1344.
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  59. YNDIGEGN T, Lindahl B, Mars K, Alfredsson J, et al
    Beta-Blockers after Myocardial Infarction and Preserved Ejection Fraction.
    N Engl J Med. 2024 Apr 7. doi: 10.1056/NEJMoa2401479.
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  60. HERRMANN HC, Mehran R, Blackman DJ, Bailey S, et al
    Self-Expanding or Balloon-Expandable TAVR in Patients with a Small Aortic Annulus.
    N Engl J Med. 2024 Apr 7. doi: 10.1056/NEJMoa2312573.
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  61. ROULEAU J
    Decreasing the Risk of Heart Failure in a Changing Post-Myocardial Infarction Environment.
    N Engl J Med. 2024 Apr 6. doi: 10.1056/NEJMe2402719.
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  62. KOSIBOROD MN, Petrie MC, Borlaug BA, Butler J, et al
    Semaglutide in Patients with Obesity-Related Heart Failure and Type 2 Diabetes.
    N Engl J Med. 2024 Apr 6. doi: 10.1056/NEJMoa2313917.
    >> Share

  63. BUTLER J, Jones WS, Udell JA, Anker SD, et al
    Empagliflozin after Acute Myocardial Infarction.
    N Engl J Med. 2024 Apr 6. doi: 10.1056/NEJMoa2314051.
    >> Share

    January 2024
  64. SAPP JL, Sivakumaran S, Redpath CJ, Khan H, et al
    Long-Term Outcomes of Resynchronization-Defibrillation for Heart Failure.
    N Engl J Med. 2024;390:212-220.
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    December 2023
  65. SOHNS C, Tijssen JGP, Sommer P
    Catheter Ablation in End-Stage Heart Failure with Atrial Fibrillation. Reply.
    N Engl J Med. 2023;389:2496-2497.
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  66. KERLEY RN, Joyce E
    Catheter Ablation in End-Stage Heart Failure with Atrial Fibrillation.
    N Engl J Med. 2023;389:2495-2496.
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  67. BLACKWELL JN, Olshansky B, Estes NAM 3rd
    Catheter Ablation in End-Stage Heart Failure with Atrial Fibrillation.
    N Engl J Med. 2023;389:2495.
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  68. KOSIBOROD MN, Borlaug BA, Petrie MC
    Semaglutide and Heart Failure with Preserved Ejection Fraction and Obesity. Reply.
    N Engl J Med. 2023;389:2398-2399.
    >> Share

  69. O'DOWLING R
    Semaglutide and Heart Failure with Preserved Ejection Fraction and Obesity.
    N Engl J Med. 2023;389:2398.
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  70. WAGNER J
    Semaglutide and Heart Failure with Preserved Ejection Fraction and Obesity.
    N Engl J Med. 2023;389:2398.
    >> Share

  71. GAO Y, Gao Y, Qiu H
    Semaglutide and Heart Failure with Preserved Ejection Fraction and Obesity.
    N Engl J Med. 2023;389:2397-2398.
    >> Share

    November 2023
  72. MENTZ RJ, Hernandez AF
    Ferric Carboxymaltose in Heart Failure with Iron Deficiency. Reply.
    N Engl J Med. 2023;389:10.
    >> Share

  73. ANKER SD, Filippatos G, Anker MS
    Ferric Carboxymaltose in Heart Failure with Iron Deficiency.
    N Engl J Med. 2023;389:10.
    >> Share

  74. EISENGA MF
    Ferric Carboxymaltose in Heart Failure with Iron Deficiency.
    N Engl J Med. 2023;389:10.
    >> Share

  75. PAYAN-PERNIA S, Perez-Simon JA, Garcia-Erce JA
    Ferric Carboxymaltose in Heart Failure with Iron Deficiency.
    N Engl J Med. 2023;389:10.
    >> Share

    October 2023
  76. MACK MJ, Leon MB, Thourani VH, Pibarot P, et al
    Transcatheter Aortic-Valve Replacement in Low-Risk Patients at Five Years.
    N Engl J Med. 2023 Oct 24. doi: 10.1056/NEJMoa2307447.
    >> Share

  77. LEWIS EF
    Catheter Ablation for Atrial Fibrillation in Heart Failure - An Option to Defer Transplantation?
    N Engl J Med. 2023;389:1429-1430.
    >> Share

    August 2023

  78. Obesity and Heart Failure.
    N Engl J Med. 2023;389:e15.
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  79. SOHNS C, Fox H, Marrouche NF, Crijns HJGM, et al
    Catheter Ablation in End-Stage Heart Failure with Atrial Fibrillation.
    N Engl J Med. 2023 Aug 27. doi: 10.1056/NEJMoa2306037.
    >> Share

  80. STAHLI BE, Varbella F, Linke A, Schwarz B, et al
    Timing of Complete Revascularization with Multivessel PCI for Myocardial Infarction.
    N Engl J Med. 2023 Aug 27. doi: 10.1056/NEJMoa2307823.
    >> Share

  81. MARTENS P, Mullens W
    Treating Iron Deficiency in Heart Failure.
    N Engl J Med. 2023 Aug 26. doi: 10.1056/NEJMe2308305.
    >> Share

  82. MENTZ RJ, Garg J, Rockhold FW, Butler J, et al
    Ferric Carboxymaltose in Heart Failure with Iron Deficiency.
    N Engl J Med. 2023 Aug 26. doi: 10.1056/NEJMoa2304968.
    >> Share

  83. KOSIBOROD MN, Abildstrom SZ, Borlaug BA, Butler J, et al
    Semaglutide in Patients with Heart Failure with Preserved Ejection Fraction and Obesity.
    N Engl J Med. 2023 Aug 25. doi: 10.1056/NEJMoa2306963.
    >> Share

  84. PINTO YM
    Heart Failure with Preserved Ejection Fraction - A Metabolic Disease?
    N Engl J Med. 2023 Aug 25. doi: 10.1056/NEJMe2309294.
    >> Share

    July 2023
  85. GARCIA-PAVIA P, Aus dem Siepen F, Donal E, Lairez O, et al
    Phase 1 Trial of Antibody NI006 for Depletion of Cardiac Transthyretin Amyloid.
    N Engl J Med. 2023;389:239-250.
    >> Share

    April 2023
  86. CHANG LL, DesJardin JT, Albert MA, Ezekowitz J, et al
    Dietary Sodium Restriction in Patients with Heart Failure.
    N Engl J Med. 2023;388:1621-1623.
    >> Share

    March 2023
  87. LEE DS, Ross HJ
    Trial of an Intervention to Improve Acute Heart Failure Outcomes. Reply.
    N Engl J Med. 2023;388:e46.
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  88. PELED H, Dau NQ
    Trial of an Intervention to Improve Acute Heart Failure Outcomes.
    N Engl J Med. 2023;388:e46.
    >> Share

  89. FAN SC, Hsu NC
    Trial of an Intervention to Improve Acute Heart Failure Outcomes.
    N Engl J Med. 2023;388:e46.
    >> Share

  90. HOUSTON BA, Brittain EL, Tedford RJ
    Right Ventricular Failure.
    N Engl J Med. 2023;388:1111-1125.
    >> Share

  91. STONE GW, Abraham WT, Lindenfeld J, Kar S, et al
    Five-Year Follow-up after Transcatheter Repair of Secondary Mitral Regurgitation.
    N Engl J Med. 2023 Mar 5. doi: 10.1056/NEJMoa2300213.
    >> Share

  92. SORAJJA P, Whisenant B, Hamid N, Naik H, et al
    Transcatheter Repair for Patients with Tricuspid Regurgitation.
    N Engl J Med. 2023 Mar 4. doi: 10.1056/NEJMoa2300525.
    >> Share


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