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Chronic Heart Failure
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Articles published in
Circ Res
    September 2026
  1. HONG J, Gillman S, Pellegrino PR, Zhao G, et al
    Neural Mechanisms of Heart-Lung Crosstalk in Chronic Heart Failure.
    Circ Res. 2026 Sep 24. doi: 10.1161/CIRCRESAHA.126.328216.
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  2. ZHOU C, Fu L, Yuan T, Li F, et al
    Mast Cell St8sia1 Is a Glyco-Epigenetic Checkpoint Driving Cardiac Remodeling.
    Circ Res. 2026;139:e328171.
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  3. LINKE WA, Kumper L, Fomin A, Martin I, et al
    Nx3 Is a Z-Disk Structural and Signaling Hub That Is Reduced in Heart Failure.
    Circ Res. 2026 Sep 10. doi: 10.1161/CIRCRESAHA.125.327786.
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    August 2026
  4. MEN L, Wang Q, Ren B, Cao Y, et al
    Small Extracellular Vesicles From Cardiomyocytes Activate Microglia Aggravating HFpEF.
    Circ Res. 2026;139:e327765.
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    July 2026
  5. DAOU D, Das Gupta S, Anand A, May HI, et al
    TFEB Antagonizes Cardiac Hypertrophy and Failure by Enhancing Lysosomal Capacity and Mitochondrial Function.
    Circ Res. 2026;139:e328083.
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  6. LI J, Ding S, Yang Z, Wang M, et al
    Metabolomic Profiles and Changes During the 20 Years Preceding Heart Failure.
    Circ Res. 2026 Jul 24. doi: 10.1161/CIRCRESAHA.126.328542.
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  7. PATEL TA, Rose J, Katsurada K, Yada T, et al
    GLP-1 Receptor Agonists: From Clinical Success to Mechanistic Insight.
    Circ Res. 2026;139:e327683.
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    June 2026
  8. GOLDBERG IJ, Young ME, Schulze PC, Drosatos K, et al
    Cardiac Lipid Metabolism: Cells, Metabolites, and Rhythms.
    Circ Res. 2026;138:e327471.
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    May 2026
  9. HEGYI B, Angsutararux P, Chakouri N, Mahling RW, et al
    Targeting Arrhythmogenic Late Sodium Current by FHF1(A)-Derivative FixR in Heart Failure Cardiomyocytes.
    Circ Res. 2026 May 26:10.1161/CIRCRESAHA.126.328204.
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  10. MERAL D, Mamazhakypov A, Koca D, Mukherjee D, et al
    Reversible Fibroblast Trajectories Regulated by MR Underlie Diastolic Dysfunction.
    Circ Res. 2026;138:e327301.
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  11. HAHN VS, Chaffin M, Simonson B, Jenkin SC, et al
    Single Cell Analysis of Human Heart Failure With Preserved Ejection Fraction.
    Circ Res. 2026 May 15. doi: 10.1161/CIRCRESAHA.125.327433.
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  12. NGUYEN VB, Kapiloff MS
    AH001: A New Drug Targeting RhoA in Heart Failure.
    Circ Res. 2026;138:e328631.
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    April 2026
  13. SCHANBACHER C, Lorenz K
    Phosphoinositides in Chronic Ang II Signaling: PTEN-A Target in Heart Failure?
    Circ Res. 2026;138:e328513.
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  14. WESTHOFF M, Voelker TL, Del Villar SG, Thai PN, et al
    Phosphoinositide Depletion and Compensatory Phospho-Signaling in Angiotensin II-Induced Heart Disease.
    Circ Res. 2026;138:e327896.
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  15. WANG X, Han S, Zhang G, Huang X, et al
    ESCRT-Mediated Machinery Directly Drives Cardiac T-tubule Formation.
    Circ Res. 2026;138:e327453.
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    March 2026
  16. RATNAVADIVEL S, Zhang J, Sheikh F
    Signal Override: Precision Editing of Protein Kinase Calpha in Heart Failure.
    Circ Res. 2026;138:e328024.
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  17. XUE M, Liang Y, Yuan Z, Liu X, et al
    Inhibiting RhoA Activation Via GDP-State Stabilization to Relieve Heart Failure.
    Circ Res. 2026 Mar 20. doi: 10.1161/CIRCRESAHA.125.327107.
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  18. HORNER KB, Mutchler AL
    Indole Loss: Hypertensive Link Between Dysbiosis and Diastolic Heart Failure.
    Circ Res. 2026;138:e328284.
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  19. ZAKARAUSKAS-SETH BI, Forcari G, Anandakumar H, Kotlar-Goldaper I, et al
    Indole-3 Acetate Limits Dysbiosis-Driven Diastolic Failure via Hcrt Neurons.
    Circ Res. 2026;138:e326990.
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    February 2026
  20. TADOKORO T, Li H, Gan P, Xu Z, et al
    Ablation of PKCalpha Phosphorylation by CRISPR-Cas9 Base Editing Rescues Heart Failure.
    Circ Res. 2026 Feb 20. doi: 10.1161/CIRCRESAHA.125.326738.
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    January 2026
  21. CARLEY AN, Maurya SK, Maurya CK, Wang Y, et al
    CPT1a Expression Is a Critical Cardioprotective Response to Pathological Stress That Enables Rescue by Gene Transfer.
    Circ Res. 2026;138:e327403.
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  22. HAYES JB, Choudhary D, Ritter D, Neininger-Castro AC, et al
    Nonmuscle alpha-Actinin-4 Couples Sarcomere Function to Cardiac Remodeling.
    Circ Res. 2026;138:e326412.
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    December 2025
  23. CHEN M, Wang Z, Li J, Teng P, et al
    Histone Lactylation Promotes Pressure Overload-Induced Cardiac Hypertrophy and Heart Failure by Regulating TGFB2 Expression.
    Circ Res. 2025 Dec 11. doi: 10.1161/CIRCRESAHA.125.326185.
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    October 2025
  24. PARTHIBAN P, Barrow F, Wang H, Chalise U, et al
    Macrophage-Derived CCL24 Promotes Cardiac Fibrosis Via Fibroblast CCR3.
    Circ Res. 2025;137:1140-1156.
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    September 2025
  25. ELBATREEK MH, Lefer DJ
    Unlocking Mitochondrial Potential: DWORF to the Rescue in Heart Failure.
    Circ Res. 2025;137:1089-1091.
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  26. YUCEL D, Ferreira de Araujo N, Souza-Neto F, Smith C, et al
    Septin4 Regulates Cardiac Fibrosis After Pressure Overload.
    Circ Res. 2025;137:1117-1132.
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  27. BRITO-ESTRADA O, Kuwabara Y, Gibson AM, Hassel KR, et al
    DWORF Gene Therapy Improves Cardiac Calcium Handling and Mitochondrial Function.
    Circ Res. 2025;137:1072-1088.
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  28. LI Z, LaPenna KB, Gehred ND, Yu X, et al
    Dysregulated Protein s-Nitrosylation Promotes Nitrosative Stress and Disease Progression in Heart Failure With Preserved Ejection Fraction.
    Circ Res. 2025 Sep 17. doi: 10.1161/CIRCRESAHA.124.326042.
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  29. WU H, Zhuang Y, Yue Y, Liu J, et al
    SPOP Is a Key Trigger of Pathological Cardiac Hypertrophy and Heart Failure.
    Circ Res. 2025 Sep 15. doi: 10.1161/CIRCRESAHA.125.326129.
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    August 2025
  30. PALACIOS-MERINO J, Lara-Pezzi E
    Cutting Loose to Hold on: A Feedback Loop Between GPLD1 and uPAR in Heart Failure.
    Circ Res. 2025;137:584-586.
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  31. KNEUER JM, Muller M, Erbe S, Kokot KE, et al
    Circulating Immune Cell Signature Analysis in HFpEF Across Species.
    Circ Res. 2025;137:682-698.
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  32. VENKATESAN T, Toumpourleka M, Niewiadomska M, Farhat K, et al
    Vagal Stimulation Rescues HFpEF by Altering Cardiac Resident Macrophage Function.
    Circ Res. 2025;137:664-681.
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  33. PERALTA TM, Zelarayan LC
    Dot1L-H3K79me2-Tbx6 Axis: A Novel Therapeutic Target for Preventing Cardiac Failure.
    Circ Res. 2025;137:513-515.
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    July 2025
  34. YU W, Guo Z, Liang H, Ma D, et al
    GPLD1 Attenuates Heart Failure via Dual Membrane Localization to Inhibit uPAR.
    Circ Res. 2025 Jul 9. doi: 10.1161/CIRCRESAHA.124.325623.
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  35. SUBRAMANIAN V, Tucker WJ, Peters AE, Upadhya B, et al
    Cardiovascular Aging and Exercise: Implications for Heart Failure Prevention and Management.
    Circ Res. 2025;137:205-230.
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  36. LEWIS GD, Tada A, Landsteiner I, Borlaug BA, et al
    Physiologic Phenotyping of Responses to Exercise and Activity in Heart Failure.
    Circ Res. 2025;137:290-315.
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  37. MOUNSEY LA, Guo M, Lau ES, Ho JE, et al
    Exercise Training in Heart Failure: Clinical Benefits and Mechanisms.
    Circ Res. 2025;137:273-289.
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    June 2025
  38. PEPIN ME, Konrad PJM, Nazir S, Bazgir F, et al
    Mitochondrial NNT Promotes Diastolic Dysfunction in Cardiometabolic HFpEF.
    Circ Res. 2025;136:1564-1578.
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    May 2025
  39. CALLER T, Moore KJ, Lehmann LH, Wu SM, et al
    Insights Into Heart-Tumor Interactions in Heart Failure.
    Circ Res. 2025;136:1262-1285.
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  40. JUGUILON C, Khosravi R, Radisic M, Wu JC, et al
    In Vitro Modeling of Interorgan Crosstalk: Multi-Organ-on-a-Chip for Studying Cardiovascular-Kidney-Metabolic Syndrome.
    Circ Res. 2025;136:1476-1493.
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  41. SALYER LG, Wang Y, Ma X, Foryst-Ludwig A, et al
    Modulating the Secretome of Fat to Treat Heart Failure.
    Circ Res. 2025;136:1363-1381.
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  42. SNELSON M, R Muralitharan R, Liu CF, Marko L, et al
    Gut-Heart Axis: The Role of Gut Microbiota and Metabolites in Heart Failure.
    Circ Res. 2025;136:1382-1406.
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  43. LEE CJM, Kosyakovsky LB, Khan MS, Wu F, et al
    Cardiovascular, Kidney, Liver, and Metabolic Interactions in Heart Failure: Breaking Down Silos.
    Circ Res. 2025;136:1170-1207.
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  44. KALLIKOURDIS M, Cochran JD, Walsh K, Condorelli G, et al
    Contributions of Noncardiac Organ-Heart Immune Crosstalk and Somatic Mosaicism to Heart Failure: Current Knowledge and Perspectives.
    Circ Res. 2025;136:1208-1232.
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  45. SCHIATTARELLA GG, Kontaridis MI
    Interorgan Crosstalk in Heart Failure and Cardiometabolic Diseases: A Compendium.
    Circ Res. 2025;136:1167-1169.
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  46. NOELS H, van der Vorst EPC, Rubin S, Emmett A, et al
    Renal-Cardiac Crosstalk in the Pathogenesis and Progression of Heart Failure.
    Circ Res. 2025;136:1306-1334.
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  47. KOAY YC, McIntosh B, Ng YH, Cao Y, et al
    The Heart Has Intrinsic Ketogenic Capacity that Mediates NAD(+) Therapy in HFpEF.
    Circ Res. 2025;136:1113-1130.
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  48. COSTANTINO S, Mohammed SA, Ambrosini S, Telesca M, et al
    Chromatin Rewiring by SETD2 Drives Lipotoxic Injury in Cardiometabolic HFpEF.
    Circ Res. 2025;136:1079-1095.
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    March 2025
  49. GHAZAL R, Wang M, Liu D, Tschumperlin DJ, et al
    Cardiac Fibrosis in the Multi-Omics Era: Implications for Heart Failure.
    Circ Res. 2025;136:773-802.
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  50. HAN X, Shi Q, Tu Y, Zhang J, et al
    Cardiomyocyte PRL2 Promotes Cardiac Hypertrophy via Directly Dephosphorylating AMPKalpha2.
    Circ Res. 2025;136:645-663.
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    December 2024
  51. MARTINI E, Cremonesi M, Felicetta A, Serio S, et al
    Autoimmune-Like Mechanism in Heart Failure Enables Preventive Vaccine Therapy.
    Circ Res. 2024 Dec 4. doi: 10.1161/CIRCRESAHA.124.324999.
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    October 2024
  52. YOSHII A, McMillen TS, Wang Y, Zhou B, et al
    Blunted Cardiac Mitophagy in Response to Metabolic Stress Contributes to HFpEF.
    Circ Res. 2024;135:1004-1017.
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    September 2024
  53. STROCCHI S, Liu L, Wang R, Haseli SP, et al
    Systems Biology Approach Uncovers Candidates for Liver-Heart Interorgan Crosstalk in HFpEF.
    Circ Res. 2024;135:873-876.
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  54. DELAUNAY M, Jebessa ZH, McKinsey TA
    Cyclophilin(g) a Knowledge Gap in Heart Failure Pathogenesis.
    Circ Res. 2024;135:774-776.
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  55. MUNRO ML, Gonano LA
    On the Mend: Atrial Tubulogenesis After Tachypacing-Induced Heart Failure.
    Circ Res. 2024;135:755-757.
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  56. SIGLE M, Rohlfing AK, Cruz Santos M, Kopp T, et al
    Targeting Cyclophilin A in the Cardiac Microenvironment Preserves Heart Function and Structure in Failing Hearts.
    Circ Res. 2024;135:758-773.
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    August 2024
  57. SANTIAGO PADILLA L, Schiattarella GG
    Targeting HFpEF: Unlocking the Potential of Glucagon Receptor Blockade.
    Circ Res. 2024;135:629-631.
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  58. BERGER JH, Matsuura TR, Bowman CE, Taing R, et al
    SGLT2 Inhibitors Act Independently of SGLT2 to Confer Benefit for HFrEF in Mice.
    Circ Res. 2024;135:632-634.
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  59. CALDWELL JL, Clarke JD, Smith CER, Pinali C, et al
    Restoring Atrial T-Tubules Augments Systolic Ca Upon Recovery From Heart Failure.
    Circ Res. 2024 Aug 14. doi: 10.1161/CIRCRESAHA.124.324601.
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  60. PAVELEC CM, Young AP, Luviano HL, Orrell EE, et al
    Cardiomyocyte PANX1 Controls Glycolysis and Neutrophil Recruitment in Hypertrophy.
    Circ Res. 2024;135:503-517.
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    July 2024
  61. GAO C, Xiong Z, Liu Y, Wang M, et al
    Glucagon Receptor Antagonist for Heart Failure With Preserved Ejection Fraction.
    Circ Res. 2024 Jul 16. doi: 10.1161/CIRCRESAHA.124.324706.
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  62. LEE CJM, Foo RS
    TRIM35: A Proposed Gateway to p53-Induced Heart Failure Pathogenesis.
    Circ Res. 2024;135:314-316.
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  63. HINTON A JR, Claypool SM, Neikirk K, Senoo N, et al
    Mitochondrial Structure and Function in Human Heart Failure.
    Circ Res. 2024;135:372-396.
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    June 2024
  64. ROMAN B, Mastoor Y, Sun J, Chapoy Villanueva H, et al
    MICU3 Regulates Mitochondrial Calcium and Cardiac Hypertrophy.
    Circ Res. 2024;135:26-40.
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  65. LORENZANA-CARRILLO MA, Tejay S, Nanoa J, Huang G, et al
    TRIM35 Monoubiquitinates H2B in Cardiac Cells, Implications for Heart Failure.
    Circ Res. 2024 Jun 11. doi: 10.1161/CIRCRESAHA.123.324202.
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  66. MALLAREDY V, Roy R, Cheng Z, Gurrala CT, et al
    Tipifarnib Reduces Extracellular Vesicles and Protects From Heart Failure.
    Circ Res. 2024 Jun 7. doi: 10.1161/CIRCRESAHA.123.324110.
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  67. ALCAIDE P, Kallikourdis M, Emig R, Prabhu SD, et al
    Myocardial Inflammation in Heart Failure With Reduced and Preserved Ejection Fraction.
    Circ Res. 2024;134:1752-1766.
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    May 2024
  68. LIEM DA, Olivera da Silva H, Romero E, Rocha P, et al
    Association of Neighborhood and Environmental Factors with Clinical Phenotypes and Outcomes in Heart Failure with Preserved Ejection Fraction.
    Circ Res. 2024 May 17. doi: 10.1161/CIRCRESAHA.124.324429.
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    April 2024
  69. QASIM H, Rajaei M, Xu Y, Reyes-Alcaraz A, et al
    AKAP12 Upregulation Associates With PDE8A to Accelerate Cardiac Dysfunction.
    Circ Res. 2024;134:1006-1022.
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    March 2024
  70. ECKLE T, Bertazzo J, Khatua TN, Fatemi Tabatabaei SR, et al
    Circadian Influences on Myocardial Ischemia-Reperfusion Injury and Heart Failure.
    Circ Res. 2024;134:675-694.
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  71. CURAJ A, Vanholder R, Loscalzo J, Quach K, et al
    Cardiovascular Consequences of Uremic Metabolites: an Overview of the Involved Signaling Pathways.
    Circ Res. 2024;134:592-613.
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    February 2024
  72. KAMRADT ML, Makarewich CA
    CHKB-DT: A Long Noncoding RNA Critical for Cardiovascular Health.
    Circ Res. 2024;134:442-444.
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  73. VACCA A, Schiattarella GG
    From Gut to Heart: Role of Indole-3-Propionic Acid in HFpEF.
    Circ Res. 2024;134:390-392.
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    January 2024
  74. WANG YC, Koay YC, Pan C, Zhou Z, et al
    Indole-3-Propionic Acid Protects Against Heart Failure With Preserved Ejection Fraction.
    Circ Res. 2024 Jan 24. doi: 10.1161/CIRCRESAHA.123.322381.
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    December 2023
  75. STEGE NM, Eijgenraam TR, Oliveira Nunes Teixeira V, Feringa AM, et al
    DWORF Extends Life Span in a PLN-R14del Cardiomyopathy Mouse Model by Reducing Abnormal Sarcoplasmic Reticulum Clusters.
    Circ Res. 2023;133:1006-1021.
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    November 2023
  76. DAI Z, Thorp EB
    New Way to Study Pulmonary Hypertension in HFpEF.
    Circ Res. 2023;133:899-901.
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  77. AGRAWAL V, Kropski JA, Gokey JJ, Kobeck E, et al
    Myeloid Cell Derived IL1beta Contributes to Pulmonary Hypertension in HFpEF.
    Circ Res. 2023;133:885-898.
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  78. KWAN Z, Paulose Nadappuram B, Leung MM, Mohagaonkar S, et al
    Microtubule-Mediated Regulation of beta(2)AR Translation and Function in Failing Hearts.
    Circ Res. 2023;133:944-958.
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    October 2023
  79. LIU D, Wang M, Murthy V, McNamara DM, et al
    Myocardial Recovery in Recent Onset Dilated Cardiomyopathy: Role of CDCP1 and Cardiac Fibrosis.
    Circ Res. 2023;133:810-825.
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    September 2023
  80. SERIO S, Pagiatakis C, Musolino E, Felicetta A, et al
    Cardiac Aging Is Promoted by Pseudohypoxia Increasing p300-Induced Glycolysis.
    Circ Res. 2023;133:687-703.
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    July 2023

  81. Correction to: SIRT6 Mitigates Heart Failure With Preserved Ejection Fraction in Diabetes.
    Circ Res. 2023;133:e48.
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  82. TANG X, Zhao S, Liu J, Liu X, et al
    Mitochondrial GSNOR Alleviates Cardiac Dysfunction via ANT1 Denitrosylation.
    Circ Res. 2023;133:220-236.
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  83. DAI Y, Ignatyeva N, Xu H, Wali R, et al
    An Alternative Mechanism of Subcellular Iron Uptake Deficiency in Cardiomyocytes.
    Circ Res. 2023;133:e19-e46.
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    June 2023
  84. FATKIN D, Ohanian M, Brown KJ
    A Novel Role for FKBP5 in Atrial Cardiomyopathy.
    Circ Res. 2023;133:45-47.
    >> Share

  85. SANCHEZ-ALONSO JL, Fedele L, Copier JS, Lucarelli C, et al
    Functional LTCC-beta(2)AR Complex Needs Caveolin-3 and Is Disrupted in Heart Failure.
    Circ Res. 2023 Jun 14. doi: 10.1161/CIRCRESAHA.123.322508.
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    May 2023
  86. NAYAKANTI SR, Friedrich A, Sarode P, Jafari L, et al
    Targeting Wnt-ss-Catenin-FOSL Signaling Ameliorates Right Ventricular Remodeling.
    Circ Res. 2023;132:1468-1485.
    >> Share

  87. BOULOS PK, Freeman SV, Henry TD, Mahmud E, et al
    Interaction of COVID-19 With Common Cardiovascular Disorders.
    Circ Res. 2023;132:1259-1271.
    >> Share

    April 2023
  88. NGUYEN TD, Schulze PC
    Cardiac Metabolism in Heart Failure and Implications for Uremic Cardiomyopathy.
    Circ Res. 2023;132:1034-1049.
    >> Share

  89. WU Z, Lohmoller J, Kuhl C, Wehrle K, et al
    Use of Computation Ecosystems to Analyze the Kidney-Heart Crosstalk.
    Circ Res. 2023;132:1084-1100.
    >> Share

    March 2023
  90. MATSUURA TR, Puchalska P, Crawford PA, Kelly DP, et al
    Ketones and the Heart: Metabolic Principles and Therapeutic Implications.
    Circ Res. 2023;132:882-898.
    >> Share

  91. YE S, Huang H, Han X, Luo W, et al
    Dectin-1 Acts as a Non-Classical Receptor of Ang II to Induce Cardiac Remodeling.
    Circ Res. 2023;132:707-722.
    >> Share

  92. CANNAVO A, Jun S, Rengo G, Marzano F, et al
    beta3AR-Dependent BDNF (Brain-Derived Neurotrophic Factor) Generation Limits Chronic Postischemic Heart Failure.
    Circ Res. 2023 Mar 8. doi: 10.1161/CIRCRESAHA.122.321583.
    >> Share

  93. HUGHES A, Shandhi MMH, Master H, Dunn J, et al
    Wearable Devices in Cardiovascular Medicine.
    Circ Res. 2023;132:652-670.
    >> Share


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