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Ischemic Heart Disease

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Articles published in
J Clin Invest
    February 2024
  1. JAFFE IZ, Karumanchi SA
    Lipid droplets in the endothelium: The missing link between metabolic syndrome and cardiovascular disease?
    J Clin Invest. 2024;134:e176347.
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    September 2023
  2. THORP EB
    Cardiac macrophages and emerging roles for their metabolism after myocardial infarction.
    J Clin Invest. 2023;133:e171953.
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    July 2023
  3. YU Z, Filder TP, Ruan Y, Vlasschaert C, et al
    Genetic modification of inflammation and clonal hematopoiesis-associated cardiovascular risk.
    J Clin Invest. 2023 Jul 27:e168597. doi: 10.1172/JCI168597.
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  4. SATO M, Neufeld EB, Playford MP, Lei Y, et al
    Cell-free high-density lipoprotein-specific phospholipid efflux assay predicts incident cardiovascular disease.
    J Clin Invest. 2023 Jul 20:e165370. doi: 10.1172/JCI165370.
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    June 2023
  5. NAKAO T, Libby P
    IL-6 helps weave the inflammatory web during acute coronary syndromes.
    J Clin Invest. 2023;133:e167670.
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  6. ALTER C, Henseler AS, Owenier C, Hesse J, et al
    IL-6 in the infarcted heart is preferentially formed by fibroblasts and modulated by purinergic signaling.
    J Clin Invest. 2023;133:e163799.
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    May 2023
  7. QUIJADA P, Park S, Zhao P, Kolluri KS, et al
    Cardiac pericytes mediate the remodeling response to myocardial infarction.
    J Clin Invest. 2023;133:e162188.
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    March 2023
  8. LEYBAERT L, De Smet MA, Lissoni A, Allewaert R, et al
    Connexin hemichannels as candidate targets for cardioprotective and anti-arrhythmic treatments.
    J Clin Invest. 2023;133:e168117.
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    February 2023
  9. WEISSMAN D, Maack C
    Mitochondrial function in macrophages controls cardiac repair after myocardial infarction.
    J Clin Invest. 2023;133:e167079.
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  10. GARLAPATI V, Molitor M, Michna T, Harms GS, et al
    Targeting myeloid cell coagulation signaling blocks MAP kinase/TGF-beta1-driven fibrotic remodeling in ischemic heart failure.
    J Clin Invest. 2023;133:e156436.
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    December 2022
  11. GOODCHILD TT, Li Z, Lefer DJ
    Soluble urokinase plasminogen activator receptor: from biomarker to active participant in atherosclerosis and cardiovascular disease.
    J Clin Invest. 2022;132:e165868.
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  12. CAI S, Zhao M, Zhou B, Yoshii A, et al
    Mitochondrial dysfunction in macrophages promotes inflammation and suppresses repair after myocardial infarction.
    J Clin Invest. 2022 Dec 8:e159498. doi: 10.1172/JCI159498.
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  13. NAGARAJAN N, Oka SI, Nah J, Wu C, et al
    Thioredoxin 1 promotes autophagy through transnitrosylation of Atg7 during myocardial ischemia.
    J Clin Invest. 2022 Dec 8:e162326. doi: 10.1172/JCI162326.
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    October 2022
  14. GARRY DJ, Yannopoulos D, Alexy T
    Revolutionizing cardiovascular medicine: targeted therapies for the cardiac conduction system.
    J Clin Invest. 2022;132.
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    September 2022
  15. BLANCO-DOMINGUEZ R, de la Fuente H, Rodriguez C, Martin-Aguado L, et al
    CD69 expression on regulatory T cells protects from immune damage after myocardial infarction.
    J Clin Invest. 2022 Sep 6. pii: 152418. doi: 10.1172/JCI152418.
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    June 2022
  16. LAGGERBAUER B, Engelhardt S
    MicroRNAs as therapeutic targets in cardiovascular disease.
    J Clin Invest. 2022;132.
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    May 2022
  17. GLINTON KE, Ma W, Lantz C, Grigoryeva LS, et al
    Macrophage-produced VEGFC is induced by efferocytosis to ameliorate cardiac injury and inflammation.
    J Clin Invest. 2022;132.
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    March 2022
  18. HENRION D
    Modulating the immune response to reduce hypertension-associated cardiovascular damage.
    J Clin Invest. 2022;132.
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    February 2022
  19. FAILER T, Amponsah-Offeh M, Neuwirth A, Kourtzelis I, et al
    Developmental endothelial locus-1 protects from hypertension-induced cardiovascular remodeling via immunomodulation.
    J Clin Invest. 2022 Feb 8. pii: 126155. doi: 10.1172/JCI126155.
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  20. HUMERES C, Shinde AV, Hanna A, Alex L, et al
    Smad7 effects on TGF-beta and ErbB2 restrain myofibroblast activation and protect from postinfarction heart failure.
    J Clin Invest. 2022;132.
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    January 2022
  21. BAILEY LR, Davis J
    If these myocytes could talk, they would speak the language of metabolites.
    J Clin Invest. 2022;132.
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  22. MUSUNURU K
    Moving toward genome-editing therapies for cardiovascular diseases.
    J Clin Invest. 2022;132.
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    November 2021
  23. JIANG K, Tu Z, Chen K, Xu Y, et al
    Gasdermin D inhibition confers antineutrophil mediated cardioprotection in acute myocardial infarction.
    J Clin Invest. 2021 Nov 9. pii: 151268. doi: 10.1172/JCI151268.
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    October 2021
  24. BRAKENHIELM E, Chen Y, Cao Y
    Lymphatics in the broken heart.
    J Clin Invest. 2021;131.
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    September 2021
  25. KNUTSON AK, Williams AL, Boisvert WA, Shohet RV, et al
    HIF in the heart: development, metabolism, ischemia, and atherosclerosis.
    J Clin Invest. 2021;131.
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    April 2021
  26. KASIKARA C, Schilperoort M, Gerlach B, Xue C, et al
    Deficiency of macrophage PHACTR1 impairs efferocytosis and promotes atherosclerotic plaque necrosis.
    J Clin Invest. 2021;131.
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