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Articles published in
Proc Natl Acad Sci U S A
    May 2026
  1. GARRIDO A, Tamayo-Torres E, Abdo S, Durham E, et al
    The antimetastatic effects of calorie restriction are negated by voluntary exercise in an aggressive breast cancer mouse model.
    Proc Natl Acad Sci U S A. 2026;123:e2524488123.
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    April 2026
  2. FARIAS A, Bridgeman VL, Rodrigues FS, Puttur F, et al
    Type I interferons induced upon respiratory viral infection impair lung metastatic initiation.
    Proc Natl Acad Sci U S A. 2026;123:e2412919123.
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  3. WILLIAMS SCP
    Profile of Helen M. Piwnica-Worms.
    Proc Natl Acad Sci U S A. 2026;123:e2609807123.
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  4. ABDULKAREEM NM, Jiang Y, Qi Y, Liu X, et al
    Resistance to neoadjuvant talazoparib in triple-negative breast cancer by BRN2-induced ATR/STAT3 pathways or SHLD2 subclone expansion.
    Proc Natl Acad Sci U S A. 2026;123:e2513742123.
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  5. OLSON AW, Li J, Li XY, King L, et al
    Amoeboid-mesenchymal transition and the proteolytic control of cancer invasion plasticity.
    Proc Natl Acad Sci U S A. 2026;123:e2520717123.
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  6. LI Z, Wang Y, Chen Z, Liu R, et al
    WFDC21P is essential for G3BP1-mediated RIG-I activation and antitumor immunity in triple-negative breast cancer.
    Proc Natl Acad Sci U S A. 2026;123:e2532576123.
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    March 2026
  7. CUI W, Xiao H, Wen X, Li C, et al
    Identifying a cancer therapeutic target: Cell-SELEX identifies a membrane protein for aptamer-mediated growth suppression.
    Proc Natl Acad Sci U S A. 2026;123:e2514681123.
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  8. FASSL A, Palacios Espinoza M, Butter D, Kolodziejczyk A, et al
    Regulation of the immune CD155-CD226-TIGIT axis by cyclin D-CDK4/6.
    Proc Natl Acad Sci U S A. 2026;123:e2522872123.
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  9. DING XH, Chen F, Yang F, Di GH, et al
    Phase separation of DDHD2 remodels lipid metabolism to dictate treatment sensitivity in luminal breast cancer.
    Proc Natl Acad Sci U S A. 2026;123:e2503019123.
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  10. CHEN HC, You SL, Lin CH, Sun CW, et al
    Elevated phthalate exposure and metabolic susceptibility increased breast cancer risk: A 20-y follow-up study in Taiwan.
    Proc Natl Acad Sci U S A. 2026;123:e2507008123.
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  11. SENTHILKUMAR I, Vangheel J, Kumar V, McNamara L, et al
    Stress-dependent growth in breast cancer arises from a mechano-osmotic coupling and cell-sizing checkpoint.
    Proc Natl Acad Sci U S A. 2026;123:e2523159123.
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  12. COTTRELL O, Rowntree A, Chopra K, Mackellar E, et al
    HES1 oscillations are required for cell cycle reentry in oestrogen receptor-positive breast cancer cells.
    Proc Natl Acad Sci U S A. 2026;123:e2520724123.
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    February 2026
  13. YAN P, Bui T, Rojas Jimenez E, Kuang Y, et al
    Aging-associated differences in mammary tumor-initiating populations and immune evasion pathways in breast cancer.
    Proc Natl Acad Sci U S A. 2026;123:e2523254123.
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  14. LOU KL, Bai JW, Liu HT, Lin LL, et al
    TROP2-targeted NIR-II fluorescence imaging for visualizing surgical margins and metastatic sentinel lymph nodes in breast cancers.
    Proc Natl Acad Sci U S A. 2026;123:e2519420123.
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  15. ROJAS-JIMENEZ E, Bui TM, Yan P, Li Z, et al
    Evaluation of targeted and immune combination therapies in a rat model of hormone receptor-positive breast cancer.
    Proc Natl Acad Sci U S A. 2026;123:e2501052123.
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  16. SERRA M, Rediti M, Collet L, Lifrange F, et al
    Spatial transcriptomics reveals tumor microenvironment-driven subtypes of invasive lobular carcinoma.
    Proc Natl Acad Sci U S A. 2026;123:e2517567123.
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    January 2026
  17. MORRISSEY RL, McDaniel JM, Chau GP, Su X, et al
    Elucidating cooperative genetic events in DCIS progression in mutant p53-driven breast cancer.
    Proc Natl Acad Sci U S A. 2026;123:e2526544123.
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    December 2025
  18. WANG X, Sun J, Lan B, Wang C, et al
    Asparagine endopeptidase prompts breast cancer-related pericardial calcification by regulating IGF2 and integrin alphavbeta5.
    Proc Natl Acad Sci U S A. 2025;122:e2512936122.
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  19. REINA J, Vallmajo-Martin Q, Ning J, Michi AN, et al
    LHPP expression in triple-negative breast cancer promotes tumor growth and metastasis by modulating the tumor microenvironment.
    Proc Natl Acad Sci U S A. 2025;122:e2505653122.
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    November 2025
  20. KLOSOWSKI ML, Cronise KE, Palmer EP, McAuliffe K, et al
    Breast cancer cell coculture induces normal lung fibroblast transition to CAFs, promoting tumor cell dormancy and therapy resistance.
    Proc Natl Acad Sci U S A. 2025;122:e2423894122.
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  21. Correction for Goyette et al., Cancer-stromal cell interactions in breast cancer brain metastases induce glycocalyx-mediated resistance to HER2-targeting therapies.
    Proc Natl Acad Sci U S A. 2025;122:e2530590122.
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  22. WANG Z, Zeng Y, Tan Z, Chen Y, et al
    A unified framework for identification of cell-type-specific spatially variable genes in spatial transcriptomic studies.
    Proc Natl Acad Sci U S A. 2025;122:e2503952122.
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  23. LI Y, Qiu X, Sandusky Z, Tagliaferri K, et al
    METTL3-dependent m6A RNA methylation suppresses aberrant mammary epithelial differentiation and neoplastic transformation.
    Proc Natl Acad Sci U S A. 2025;122:e2514643122.
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  24. WU CCN, De Luna N, Hairston E, Jeffs ED, et al
    FZD7 expression marks mammary tumor-initiating cells.
    Proc Natl Acad Sci U S A. 2025;122:e2522465122.
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  25. AYLON Y, Furth N, Pirona AC, Lavie A, et al
    p53 regulates the expression of histone modifiers to restrict stemness and maintain differentiated luminal identity in breast cancer.
    Proc Natl Acad Sci U S A. 2025;122:e2522646122.
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    October 2025
  26. PIERCE SB, Kortbawi H, Gulsuner S, Mandell JB, et al
    Genetic regulation of the estrogen receptor and inherited predisposition to breast cancer.
    Proc Natl Acad Sci U S A. 2025;122:e2517736122.
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  27. ERDOGMUS S, Srinivas N, Mollaoglu G
    Guardians at the border: Peritumoral macrophages fight breast cancer.
    Proc Natl Acad Sci U S A. 2025;122:e2523640122.
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  28. BERGMAN RE, Keeton CI, Sinha IR, Ling JP, et al
    Distinct and convergent effects of SF3B1 mutations in human breast cancer.
    Proc Natl Acad Sci U S A. 2025;122:e2505374122.
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    September 2025

  29. Correction for Wang et al., Interplay of mevalonate and Hippo pathways regulates RHAMM transcription via YAP to modulate breast cancer cell motility.
    Proc Natl Acad Sci U S A. 2025;122:e2518601122.
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  30. SAGLIMBENI J, Esteva E, Canales J, Perez OA, et al
    Peritumoral macrophages recruit eosinophils to promote antitumor immune responses in breast cancer.
    Proc Natl Acad Sci U S A. 2025;122:e2504645122.
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  31. ZHANG J, Zhang J, Han L, Wu S, et al
    Inflammation awakens dormant cancer cells by modulating the epithelial-mesenchymal phenotypic state.
    Proc Natl Acad Sci U S A. 2025;122:e2515009122.
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  32. DANG CAO TL, Kawanishi K, Hashimoto S, Hengphasatporn K, et al
    Tumor-expressed GPNMB orchestrates Siglec-9(+) TAM polarization and EMT to promote metastasis in triple-negative breast cancer.
    Proc Natl Acad Sci U S A. 2025;122:e2503081122.
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    August 2025
  33. KHAN F, Liu Y, Whitfield D, Pang L, et al
    Macrophage TBK1 signaling drives the development and outgrowth of breast cancer brain metastasis.
    Proc Natl Acad Sci U S A. 2025;122:e2420793122.
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  34. KARNER ER, Wang M, Goel HL, Mercurio AM, et al
    GATA3 promotes ferroptosis resistance by repressing integrin beta1 signaling.
    Proc Natl Acad Sci U S A. 2025;122:e2427304122.
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  35. PADRAO N, Gregoricchio S, Eickhoff N, Dong J, et al
    TRIM24 as a therapeutic target in endocrine treatment-resistant breast cancer.
    Proc Natl Acad Sci U S A. 2025;122:e2507571122.
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  36. VUILLE JA, Tanriover C, Antmen E, Micalizzi DS, et al
    The E3 ligase HECTD4 regulates COX-2-dependent tumor progression and metastasis.
    Proc Natl Acad Sci U S A. 2025;122:e2425621122.
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    July 2025
  37. BOYER JA, Rosen EY, Sharma M, Dorso MA, et al
    eIF4A controls translation of estrogen receptor alpha and is a therapeutic target in advanced breast cancer.
    Proc Natl Acad Sci U S A. 2025;122:e2424286122.
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  38. Correction to Supporting Information for Yi et al., Transcriptional suppression of AMPKalpha1 promotes breast cancer metastasis upon oncogene activation.
    Proc Natl Acad Sci U S A. 2025;122:e2516641122.
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  39. HORWITZ E, Dubash TD, Szabolcs A, Wittner BS, et al
    CDKN1B (p27/kip1) enhances drug-tolerant persister CTCs by restricting polyploidy following mitotic inhibitors.
    Proc Natl Acad Sci U S A. 2025;122:e2507203122.
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  40. SUN R, Jiang P, Wang Z, Yan B, et al
    DNA2 protein destruction dictates DNA hyperexcision, cGAS-STING activation, and innate immune response in CDK12-deregulated cancers.
    Proc Natl Acad Sci U S A. 2025;122:e2413732122.
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  41. ZOU Y, Wang Z, Jiang Q, Kong X, et al
    UFMylation: A supervisor of the HIF1alpha pathway and a potential therapeutic target for anti-PD-1 combination therapy in hypoxic tumors.
    Proc Natl Acad Sci U S A. 2025;122:e2500562122.
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  42. GUO J, Li K, Ming Y, Pan Y, et al
    A circular RNA overcomes acquired resistance to BET inhibitors by antagonizing IGF2BP2-mediated c-MYC translation in TNBC.
    Proc Natl Acad Sci U S A. 2025;122:e2504320122.
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  43. LIM J, Jung HD, Park SY, Jeon M, et al
    Genome-scale knockout simulation and clustering analysis of drug-resistant breast cancer cells reveal drug sensitization targets.
    Proc Natl Acad Sci U S A. 2025;122:e2425384122.
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    June 2025
  44. ZENG W, Guo H, Liu Q, Wong WH, et al
    Improving polygenic prediction from whole-genome sequencing data by leveraging predicted epigenomic features.
    Proc Natl Acad Sci U S A. 2025;122:e2419202122.
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  45. OZAKI MK, Zhang Y, Bartlett AQ, de Wilde E, et al
    Reproductive state controls transcription in the murine liver, with implications for breast cancer liver metastasis.
    Proc Natl Acad Sci U S A. 2025;122:e2420174122.
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  46. DING Q, Liu J, Wang Y, Kim J, et al
    Dual-laser "808 and 1,064 nm" strategy that circumvents the Achilles' heel of photothermal therapy.
    Proc Natl Acad Sci U S A. 2025;122:e2503574122.
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    May 2025
  47. FERRERO G, Cardamone MD, Luca F, Bourk E, et al
    Nonproteolytic ubiquitination regulates chromatin occupancy by the NCoR/SMRT/HDAC3 corepressor complex in MCF-7 breast cancer cells.
    Proc Natl Acad Sci U S A. 2025;122:e2502805122.
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    April 2025
  48. CHEN YF, Zhang QH, Zhang ZW, Zhou YJ, et al
    SNX10 deficiency impairs sensitivity to anti-HER2 antibody-drug conjugates via altering HER2 trafficking in HER2-positive breast cancer.
    Proc Natl Acad Sci U S A. 2025;122:e2417586122.
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  49. ZHAO X, Zhao Y, Li Z, Liu H, et al
    Proximity-activated DNA scanning encoded sequencing for massive access to membrane proteins nanoscale organization.
    Proc Natl Acad Sci U S A. 2025;122:e2425000122.
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    March 2025

  50. Correction for Qin et al., A signaling molecule from intratumor bacteria promotes trastuzumab resistance in breast cancer cells.
    Proc Natl Acad Sci U S A. 2025;122:e2502214122.
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  51. STAROSTECKA M, Jeong H, Hasenfeld P, Benito-Garagorri E, et al
    Structural variant and nucleosome occupancy dynamics postchemotherapy in a HER2+ breast cancer organoid model.
    Proc Natl Acad Sci U S A. 2025;122:e2415475122.
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    February 2025
  52. YI J, Du J, Chen X, Nie RC, et al
    A circRNA-mRNA pairing mechanism regulates tumor growth and endocrine therapy resistance in ER-positive breast cancer.
    Proc Natl Acad Sci U S A. 2025;122:e2420383122.
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  53. LEI L, Song Y, Yang L, Wang Y, et al
    Triethylamine-mediated protonation-deprotonation unlocks dual-drug self assembly to suppress breast cancer progression and metastasis.
    Proc Natl Acad Sci U S A. 2025;122:e2416796122.
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    January 2025
  54. QIN G, Shao X, Liu X, Xu J, et al
    A signaling molecule from intratumor bacteria promotes trastuzumab resistance in breast cancer cells.
    Proc Natl Acad Sci U S A. 2025;122:e2421710122.
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  55. ZHENG M, Wang S, Tang K, Kong R, et al
    The CYLD-PARP1 feedback loop regulates DNA damage repair and chemosensitivity in breast cancer cells.
    Proc Natl Acad Sci U S A. 2025;122:e2413890121.
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    December 2024
  56. GONZALEZ-FERNANDEZ M, Perry C, Gerhards NM, Francica P, et al
    Docetaxel response in BRCA1,p53-deficient mammary tumor cells is affected by Huntingtin and BAP1.
    Proc Natl Acad Sci U S A. 2024;121:e2402849121.
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  57. SINHA A, Saini KK, Chandramouli A, Tripathi K, et al
    ACSL4-mediated H3K9 and H3K27 hyperacetylation upregulates SNAIL to drive TNBC metastasis.
    Proc Natl Acad Sci U S A. 2024;121:e2408049121.
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  58. MATSUZAKI T, Fujii M, Noro H, Togo S, et al
    Simultaneous visualization of membrane fluidity and morphology defines adhesion signatures of cancer cells.
    Proc Natl Acad Sci U S A. 2024;121:e2412914121.
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    November 2024
  59. DING X, Liang J, Sharko AC, Hilimire TA, et al
    Mediator kinase inhibitors suppress triple-negative breast cancer growth and extend tumor suppression by mTOR and AKT inhibitors.
    Proc Natl Acad Sci U S A. 2024;121:e2414501121.
    >> Share

  60. ARULRAJ T, Wang H, Deshpande A, Varadhan R, et al
    Virtual patient analysis identifies strategies to improve the performance of predictive biomarkers for PD-1 blockade.
    Proc Natl Acad Sci U S A. 2024;121:e2410911121.
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    October 2024
  61. LI C, Kaur A, Pavlidaki A, Spenle C, et al
    Targeting the MAtrix REgulating MOtif abolishes several hallmarks of cancer, triggering antitumor immunity.
    Proc Natl Acad Sci U S A. 2024;121:e2404485121.
    >> Share

  62. BALDASSARRI I, Tavakol DN, Graney PL, Chramiec AG, et al
    An engineered model of metastatic colonization of human bone marrow reveals breast cancer cell remodeling of the hematopoietic niche.
    Proc Natl Acad Sci U S A. 2024;121:e2405257121.
    >> Share


  63. Correction for Zhang et al., HIF-1 regulates CD47 expression in breast cancer cells to promote evasion of phagocytosis and maintenance of cancer stem cells.
    Proc Natl Acad Sci U S A. 2024;121:e2418194121.
    >> Share

  64. ASEMOTA S, Effah W, Holt J, Johnson D, et al
    A molecular switch from tumor suppressor to oncogene in ER+ve breast cancer: Role of androgen receptor, JAK-STAT, and lineage plasticity.
    Proc Natl Acad Sci U S A. 2024;121:e2406837121.
    >> Share

    September 2024
  65. FENG X, Yang C, Huang Y, Su D, et al
    In vivo CRISPR screens identify Mga as an immunotherapy target in triple-negative breast cancer.
    Proc Natl Acad Sci U S A. 2024;121:e2406325121.
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    August 2024
  66. CHIANG HC, Qi L, Mitra P, Huang Y, et al
    R-loop functions in Brca1-associated mammary tumorigenesis.
    Proc Natl Acad Sci U S A. 2024;121:e2403600121.
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    July 2024
  67. SHAH OS, Nasrazadani A, Foldi J, Atkinson JM, et al
    Spatial molecular profiling of mixed invasive ductal and lobular breast cancers reveals heterogeneity in intrinsic molecular subtypes, oncogenic signatures, and mutations.
    Proc Natl Acad Sci U S A. 2024;121:e2322068121.
    >> Share

  68. ZIN I, China A, Khan K, Nag JK, et al
    AKT-dependent nuclear localization of EPRS1 activates PARP1 in breast cancer cells.
    Proc Natl Acad Sci U S A. 2024;121:e2303642121.
    >> Share

  69. ZHOU Q, Yu H, Chen Y, Ren J, et al
    The CRL3(KCTD10) ubiquitin ligase-USP18 axis coordinately regulates cystine uptake and ferroptosis by modulating SLC7A11.
    Proc Natl Acad Sci U S A. 2024;121:e2320655121.
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    June 2024
  70. RUAN ML, Ni WX, Chu JCH, Lam TL, et al
    Iridium(III) carbene complexes as potent girdin inhibitors against metastatic cancers.
    Proc Natl Acad Sci U S A. 2024;121:e2316615121.
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    May 2024
  71. CHEN J, Liu X, Zou Y, Gong J, et al
    A high-fat diet promotes cancer progression by inducing gut microbiota-mediated leucine production and PMN-MDSC differentiation.
    Proc Natl Acad Sci U S A. 2024;121:e2306776121.
    >> Share

  72. ASHOKAN A, Sarkar S, Kamran MZ, Surnar B, et al
    Simultaneous targeting of peripheral and brain tumors with a therapeutic nanoparticle to disrupt metabolic adaptability at both sites.
    Proc Natl Acad Sci U S A. 2024;121:e2318119121.
    >> Share

  73. GOYETTE MA, Stevens LE, DePinho CR, Seehawer M, et al
    Cancer-stromal cell interactions in breast cancer brain metastases induce glycocalyx-mediated resistance to HER2-targeting therapies.
    Proc Natl Acad Sci U S A. 2024;121:e2322688121.
    >> Share

    April 2024
  74. MONDAL DK, Xie C, Pascal GJ, Buraschi S, et al
    Decorin suppresses tumor lymphangiogenesis: A mechanism to curtail cancer progression.
    Proc Natl Acad Sci U S A. 2024;121:e2317760121.
    >> Share

    March 2024
  75. WANG D, Tang M, Zhang P, Yang K, et al
    Activation of ERbeta hijacks the splicing machinery to trigger R-loop formation in triple-negative breast cancer.
    Proc Natl Acad Sci U S A. 2024;121:e2306814121.
    >> Share

  76. TAYLOR-PHILLIPS S, Jenkinson D, Stinton C, Kunar MA, et al
    Fatigue and vigilance in medical experts detecting breast cancer.
    Proc Natl Acad Sci U S A. 2024;121:e2309576121.
    >> Share

  77. LAMIA KA
    Telling time in tumor samples reveals diversity of clock disruption.
    Proc Natl Acad Sci U S A. 2024;121:e2401496121.
    >> Share


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