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Autoimmune Disorders

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Articles published in
J Immunol
    August 2026
  1. CORTEZ A, Mendyka LK, Roy A, Skydel JJ, et al
    A skin-kidney neutrophil axis links ultraviolet exposure to renal angiogenesis and tissue remodeling in healthy and lupus kidneys.
    J Immunol. 2026;215:vkag178.
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  2. SCHARMANN SD, Faber F, Hoorens van Heyningen L, Reljic M, et al
    Nanobodies specific for Vbeta11 enable detection and noninvasive imaging of antigen-specific T cells in vivo.
    J Immunol. 2026;215:vkag237.
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    July 2026
  3. KANNAN SK, Turner TJ, Heidarian M, Mix MR, et al
    Whole-body irradiation causes long-term impairments in the maintenance and function of naive CD4 T cells specific for self- and non-self-antigens.
    J Immunol. 2026;215:vkag174.
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  4. KUMAR M, Wilhelm CR, Boyden AW
    Modeling pathogenic B cell function in experimental autoimmune encephalomyelitis.
    J Immunol. 2026;215:vkag163.
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  5. PRADO DE MAIO D, Tetteh S, Ayers C, St Martin A, et al
    Lowering CD40L expression in murine lupus results in an increase in disease indicators in female but not male B6 mice.
    J Immunol. 2026;215:vkag205.
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    May 2026
  6. PATINO-MARTINEZ E, Hajihosseini M, Hanata N, Jiang K, et al
    Longitudinal multiomic and spatial transcriptomic profiling of lupus nephritis progression in a murine model.
    J Immunol. 2026;215:vkag100.
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  7. AKBAR I, Arokia Doss PMI, Patel PU, Surury B, et al
    Myelin antigen-specific effector CD8+ T cells induce chronic CNS autoimmunity in a CD4+ T cell-dependent manner.
    J Immunol. 2026;215:vkag107.
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  8. ROMO-TENA J, Sengupta S, Carmona-Rivera C, Nakabo S, et al
    Preconditioning determines engraftment and therapeutic efficacy of anti-CD19 CAR-T cells in murine lupus.
    J Immunol. 2026;215:vkag112.
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    April 2026
  9. AL-HALLAF R, Agha Z, Caturegli P, Rosenberg A, et al
    Leveraging a naturally occurring IgM autoantibody to target diabetogenic T cells: a precision medicine approach to type 1 diabetes.
    J Immunol. 2026;215:vkag056.
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  10. HORNICK EL, Oxley K, Debreceni IL, Wieting N, et al
    Syk inhibition limits autoimmunity and abnormal B cell phenotype and function in mice with B cell-specific TRAF3 deficiency.
    J Immunol. 2026;215:vkag049.
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  11. KHANDELWAL S, Chen J, Myoung SS, Lee GM, et al
    The influence of nuclear antigen form on complement activation by systemic lupus erythematosus antinuclear antibody immune complexes determined by a novel immunocapture assay.
    J Immunol. 2026;215:vkag088.
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  12. SHANG XY, Zhang R, Tan LG, Wang HY, et al
    The autoantibody beta1-AA contributes to N/OFQ-exacerbated ventricular arrhythmias following acute myocardial ischemia.
    J Immunol. 2026;215:vkag072.
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  13. ZHU Y, Choi SC, Shlomchik MJ, Morel L, et al
    GLUT1-mediated glucose flux constrains autoreactive but not foreign antigen-specific B-cell responses.
    J Immunol. 2026;215:vkag092.
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  14. GANUGULA R, Babalola KT, Arora M, Maruvada V, et al
    Combined cyclosporine A and urolithin A therapy ameliorates murine lupus nephritis.
    J Immunol. 2026;215:vkag087.
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    March 2026
  15. PREMACHANDRAN S, Groh AMR, Sinott A, Senthil S, et al
    Margins of control: ventricular brain borders as architects in central nervous system autoimmunity.
    J Immunol. 2026;215.
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  16. YIN M, Hiam-Galvez KJ, Proekt I, Chan J, et al
    Immune checkpoints in a genetically engineered mouse model of spontaneous autoimmune uveitis.
    J Immunol. 2026;215:vkaf334.
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    February 2026
  17. MIZUNO Y, Matsushita H, Fukushima Y, Kobuchi S, et al
    Endothelial semaphorin 6D controls immune responses under cold stress through regulation of sympathetic innervation.
    J Immunol. 2026;215:vkaf362.
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  18. AMDARE N, Ali R, Manganaro A, Baker JC, et al
    Islet-derived T cells from both mice and humans recognize conserved insulin A-chain peptides presented by HLA-C*03:04.
    J Immunol. 2026;215:vkaf381.
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  19. CHEN J, Fu L, Gong Y, Liao L, et al
    IFNgamma/JAK/STAT1/CD38 pathway in SH2D1Bhigh NK cells: Implications for inflammation in type 1 diabetes.
    J Immunol. 2026;215:vkaf347.
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    December 2025
  20. CONWAY H, Bernard J, Ramos R, Zahran S, et al
    Altered B cell metabolic pathways characterize type 1 diabetes progression.
    J Immunol. 2025 Dec 27:vkaf330. doi: 10.1093.
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  21. OLEINIKA K, Correia Ferreira A, Mouftakir S, Castrillon C, et al
    Dynamic control of autoreactive B cells from spontaneous germinal centers.
    J Immunol. 2025;214:3208-3217.
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  22. ROY U, Raghavan SC
    Regulation of B-cell development and differentiation by microRNAs during immune response and their implications in immunological disorders.
    J Immunol. 2025;214:3199-3207.
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  23. PANDEY JP
    Immunoglobulin GM (gamma marker) allotypes and their role in immune response and disease susceptibility.
    J Immunol. 2025;214:3181-3187.
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    November 2025
  24. DIAS DA ROCHA LIMA A, De Oliveira MG, Ferrari B, C Fonseca R, et al
    Dimethyl fumarate protects from experimental autoimmune encephalomyelitis by modulating colonic immune cells.
    J Immunol. 2025 Nov 1:vkaf289. doi: 10.1093.
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  25. YU R, Kim S, Li S, Yang W, et al
    Intronic miR-342 is a key regulator of cellular glycolysis in Foxp3+ regulatory CD4 T cells.
    J Immunol. 2025;214:2976-2986.
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    October 2025
  26. CHURCH ME, Hernandez SI, Alvarez JI
    Neuroinflammatory canine disorders: unveiling disease mechanisms from a One Health perspective.
    J Immunol. 2025;214:2535-2542.
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    September 2025
  27. ZIPFEL PF, Heidenreich K
    The 4 functional segments of Factor H: Role in physiological target recognition and contribution to disease.
    J Immunol. 2025;214:2150-2164.
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  28. LIU F, Wawersik S, Tomlinson S, Thurman JM, et al
    Tissue-targeted regulators of complement for amelioration of human disease: rationale and novel therapeutic strategies.
    J Immunol. 2025;214:2138-2149.
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    August 2025
  29. RACINE JJ, Dwyer JR, Chapman HD, Bell A, et al
    Direct-in-NOD genetic ablation of Bcl3 leads to complete type 1 diabetes protection.
    J Immunol. 2025 Aug 12:vkaf189. doi: 10.1093.
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    July 2025
  30. OO TT, Hariharasubramanian A, Pallikonda Chakravarthy S, Singh N, et al
    Age-related decline in HMGB1-neutralizing IgM autoantibody response impairs resistance to high-fat diet in mice.
    J Immunol. 2025 Jul 29:vkaf172. doi: 10.1093.
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  31. VDOVENKO D, Stefanska M, Wijnen WJ, Zarak-Crnkovic M, et al
    IL-23 promotes T cell trafficking in experimental autoimmune myocarditis.
    J Immunol. 2025 Jul 21:vkaf150. doi: 10.1093.
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    June 2025
  32. JIANG K, Xu Y, Wang Y, Yin N, et al
    Deciphering the role of IL-17D, its newly identified receptor CD93, and IL-17D-CD93 axis in health and disease.
    J Immunol. 2025;214:1113-1122.
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  33. ZHEN Y, Shao WH
    WDFY1-expressing follicular dendritic cells play a critical role in lupus development in cGVHD mouse model.
    J Immunol. 2025;214:1160-1172.
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    May 2025
  34. CHEN N, Wu J, Sun D, Kaplan HJ, et al
    Mice deficient of G-protein coupled receptor 3 (GPR3) developed severe experimental autoimmune uveitis (EAU) through increased effector T cell activities.
    J Immunol. 2025 May 17:vkaf099. doi: 10.1093.
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    April 2025
  35. TURICEK DP, Wan X
    Decoding autoimmunity: HLA-DQbeta and type 1 diabetes.
    J Immunol. 2025 Apr 28:vkaf070. doi: 10.1093.
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  36. ZHENG G, Oo TT, Janjam SSS, Ellis C, et al
    An antigen-less pro-vaccine for treating autoimmunity.
    J Immunol. 2025 Apr 24:vkaf068. doi: 10.1093.
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  37. AHN SH, Halgren K, Grzesiak G, MacRenaris KW, et al
    Autoimmune regulator deficiency causes sterile epididymitis and impacts male fertility through disruption of inorganic physiology.
    J Immunol. 2025 Apr 23:vkaf054. doi: 10.1093.
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  38. DICILLO EB, Pisetsky DS, Svenungsson E, Diaz-Gallo LM, et al
    Characterization of autoantibody profiles in clusters of systemic lupus erythematosus using a novel autoantigen discovery technology.
    J Immunol. 2025 Apr 3:vkae025. doi: 10.1093.
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    March 2025
  39. SUAN D, Moore J, Goodnow CC
    Can autoimmune disease be cured by deep CD19+ cell depletion?
    J Immunol. 2025 Mar 21:vkaf008. doi: 10.1093.
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  40. HUI CW, Wu WC, Tong TK, Shiu C, et al
    Discovery of a new anti-gammac antibody in clinical development for the treatment of autoimmune diseases.
    J Immunol. 2025 Mar 12:vkae020. doi: 10.1093.
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    January 2025
  41. HIGDON LE, Cooney LA, Serti E, Suwannasaen D, et al
    Early expansion of TIGIT+PD1+ effector memory CD4 T cells via agonistic effect of alefacept in new-onset type 1 diabetes.
    J Immunol. 2025;214:12-22.
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    October 2024
  42. PENG W, Merlo LMF, Grabler S, Montgomery JD, et al
    IDO2 Drives Autoantibody Production and Joint Inflammation in a Preclinical Model of Arthritis by Repressing Runx1 Function in B Cells.
    J Immunol. 2024 Oct 14:ji2400445. doi: 10.4049/jimmunol.2400445.
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  43. TAYLOR JP, Blum SI, Graffeo HC, Shang Q, et al
    The Type 1 Diabetes-Associated Single Nucleotide Polymorphism rs1990760 in IFIH1 Is Associated with Increased Basal Type I IFNs and IFN-stimulated Gene Expression.
    J Immunol. 2024 Oct 7:ji2400344. doi: 10.4049/jimmunol.2400344.
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  44. LEBER A, Hontecillas R, Tubau-Juni N, Fitch SN, et al
    Immunometabolic Mechanisms of LANCL2 in CD4+ T Cells and Phagocytes Provide Protection from Systemic Lupus Erythematosus.
    J Immunol. 2024 Oct 4:ji2400127. doi: 10.4049/jimmunol.2400127.
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    September 2024
  45. ZHONG B, Zhou JQ, Lyu X, Liu H, et al
    Anti-Heat Shock Protein 70 Autoantibodies from Patients with Idiopathic Pulmonary Fibrosis Epigenetically Enhance Lung Fibroblast Apoptosis Resistance and Bcl-2 Expression.
    J Immunol. 2024 Sep 9:ji2400106. doi: 10.4049/jimmunol.2400106.
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  46. LIU JQ, Jabbari A, Lin CH, Akkanapally V, et al
    IL-27 Gene Therapy Ameliorates IPEX Syndrome Caused by Germline Mutation of Foxp3 Gene: A Major Role for Induction of IL-10.
    J Immunol. 2024;213:559-566.
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    August 2024
  47. BLEVINS LK, Khan DMIO, Crawford RB, O'Neill C, et al
    CD9 and Aryl Hydrocarbon Receptor Are Markers of Human CD19+CD14+ Atypical B Cells and Are Dysregulated in Systemic Lupus Erythematous Disease.
    J Immunol. 2024 Aug 30:ji2400193. doi: 10.4049/jimmunol.2400193.
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  48. SANTANA S, Papillion A, Foote JB, Bachus H, et al
    Cutting Edge: Low-dose Recombinant IL-2 Treatment Prevents Autoantibody Responses in Systemic Lupus Erythematosus via Regulatory T Cell-independent Depletion of T Follicular Helper Cells.
    J Immunol. 2024 Aug 28:ji2400264. doi: 10.4049/jimmunol.2400264.
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  49. GREBINOSKI S, Pieklo G, Zhang Q, Visperas A, et al
    Regulatory T Cell Insufficiency in Autoimmune Diabetes Is Driven by Selective Loss of Neuropilin-1 on Intraislet Regulatory T Cells.
    J Immunol. 2024 Aug 7:ji2300216. doi: 10.4049/jimmunol.2300216.
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  50. ZHANG J, Ji H, Liu M, Zheng M, et al
    Mitochondrial DNA Programs Lactylation of cGAS to Induce IFN Responses in Patients with Systemic Lupus Erythematosus.
    J Immunol. 2024 Aug 2:ji2300758. doi: 10.4049/jimmunol.2300758.
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    July 2024
  51. CHIU H, Weinstein KN, Spath S, Hu A, et al
    SKI Regulates Medullary Thymic Epithelial Cell Differentiation to Control Peripheral T Cell Responses in Mice.
    J Immunol. 2024;213:52-62.
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  52. PATINO-MARTINEZ E, Nakabo S, Jiang K, Carmona-Rivera C, et al
    The Aconitate Decarboxylase 1/Itaconate Pathway Modulates Immune Dysregulation and Associates with Cardiovascular Disease Markers and Disease Activity in Systemic Lupus Erythematosus.
    J Immunol. 2024 Jul 1:ji2400241. doi: 10.4049/jimmunol.2400241.
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    June 2024
  53. VISWANATH V, Mistry S, Cabrera-Ghayouri S, Leang R, et al
    Sustained Alleviation of Autoimmunity by Activating alpha2B-adrenergic Receptors.
    J Immunol. 2024 Jun 28:ji2300893. doi: 10.4049/jimmunol.2300893.
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  54. CARBONE F, Colamatteo A, La Rocca C, Lepore MT, et al
    Metabolic Plasticity of Regulatory T Cells in Health and Autoimmunity.
    J Immunol. 2024;212:1859-1866.
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  55. VEMULAWADA C, Renavikar PS, Crawford MP, Steward-Tharp S, et al
    Disruption of IFNgamma, GZMB, PRF1, or LYST Results in Reduced Suppressive Function in Human CD8+ T Cells.
    J Immunol. 2024;212:1722-1732.
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    May 2024
  56. WON KD, Gil Gonzalez L, Cruz-Leal Y, Pavon Oro A, et al
    Antagonism of the Platelet-Activating Factor Pathway Mitigates Inflammatory Adverse Events Driven by Anti-erythrocyte Antibody Therapy in Mice.
    J Immunol. 2024;212:1531-1539.
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  57. DAI YD, Du W, Wang Y, Hu WY, et al
    A Targeted Deep Sequencing Method to Quantify Endogenous Retrovirus Gag Sequence Variants and Open Reading Frames Expressed in Nonobese Diabetic Mice.
    J Immunol. 2024 May 13:ji2300660. doi: 10.4049/jimmunol.2300660.
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    April 2024
  58. TAO Q, Chen Y, Liang Q, Shi J, et al
    Puerarin Alleviates Experimental Autoimmune Thyroiditis by Regulating Macrophages.
    J Immunol. 2024 Apr 26:ji2300779. doi: 10.4049/jimmunol.2300779.
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  59. LORANT AK, Yoshida AE, Gilbertson EA, Chu T, et al
    Integrin alphavbeta3 Limits Cytokine Production by Plasmacytoid Dendritic Cells and Restricts TLR-Driven Autoimmunity.
    J Immunol. 2024 Apr 12:ji2300290. doi: 10.4049/jimmunol.2300290.
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  60. DE GEORGE DJ, Jhala G, Selck C, Trivedi P, et al
    Altering beta Cell Antigen Exposure to Exhausted CD8+ T Cells Prevents Autoimmune Diabetes in Mice.
    J Immunol. 2024 Apr 8:ji2300785. doi: 10.4049/jimmunol.2300785.
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  61. FRANK C, Salapa HE, Allen KJH, Levin MC, et al
    Antibody-Mediated Depletion of Autoreactive T Lymphocytes through PD-1 Improves Disease Outcomes and Visualizes T Cell Activation in Experimental Autoimmune Encephalomyelitis.
    J Immunol. 2024 Apr 5:ji2300751. doi: 10.4049/jimmunol.2300751.
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  62. WU J, Han K, Sack MN
    Targeting NAD+ Metabolism to Modulate Autoimmunity and Inflammation.
    J Immunol. 2024;212:1043-1050.
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    March 2024
  63. COSTANZO A, Clarke D, Holt M, Sharma S, et al
    Repositioning the Early Pathology of Type 1 Diabetes to the Extraislet Vasculature.
    J Immunol. 2024 Mar 1:ji2300769. doi: 10.4049/jimmunol.2300769.
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    February 2024
  64. KAGOHASHI K, Sasaki Y, Ozawa K, Tsuchiya T, et al
    Role of Signal-Transducing Adaptor Protein-1 for T Cell Activation and Pathogenesis of Autoimmune Demyelination and Airway Inflammation.
    J Immunol. 2024 Feb 5:ji2300202. doi: 10.4049/jimmunol.2300202.
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  65. DUAN S, Li Q, Wang F, Kuang W, et al
    Single-Cell Transcriptomes and Immune Repertoires Reveal the Cell State and Molecular Changes in Pemphigus Vulgaris.
    J Immunol. 2024;212:375-388.
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    January 2024
  66. DAR AA, Ortega Y, Aktas S, Wu K, et al
    CRL4b Inhibition Ameliorates Experimental Autoimmune Encephalomyelitis Progression.
    J Immunol. 2024 Jan 24:ji2300754. doi: 10.4049/jimmunol.2300754.
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  67. YANDAMURI SS, Filipek B, Lele N, Cohen I, et al
    A Noncanonical CD56dimCD16dim/- NK Cell Subset Indicative of Prior Cytotoxic Activity Is Elevated in Patients with Autoantibody-Mediated Neurologic Diseases.
    J Immunol. 2024 Jan 22:ji2300015. doi: 10.4049/jimmunol.2300015.
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  68. TOMALA J, Cao SD, Spangler JB
    Engineering Anticytokine Antibodies for Immune Modulation.
    J Immunol. 2024;212:225-234.
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  69. HAN K, Xu J, Xie F, Crowther J, et al
    Engineering Strategies to Modulate the Gut Microbiome and Immune System.
    J Immunol. 2024;212:208-215.
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  70. KLUG N, Burke J, Scott E
    Rational Engineering of Islet Tolerance via Biomaterial-Mediated Immune Modulation.
    J Immunol. 2024;212:216-224.
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    December 2023
  71. FLYNN AL, Gans J, Escobedo J, Zhu C, et al
    RGS1 Modulates Autophagic and Metabolic Programs and Is a Critical Mediator of Human Regulatory T Cell Function.
    J Immunol. 2023;211:1656-1668.
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    November 2023
  72. SONI C, Makita S, Eichinger A, Serpas L, et al
    Cutting Edge: TLR2 Signaling in B Cells Promotes Autoreactivity to DNA via IL-6 Secretion.
    J Immunol. 2023;211:1475-1480.
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  73. LU Y, Chiang J, Zhang R, Roche PA, et al
    TRAF6 and TRAF2/3 Binding Motifs in CD40 Differentially Regulate B Cell Function in T-Dependent Antibody Responses and Dendritic Cell Function in Experimental Autoimmune Encephalomyelitis.
    J Immunol. 2023 Nov 3:ji2300607. doi: 10.4049/jimmunol.2300607.
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  74. MONSON N, Smith C, Greenberg H, Plumb P, et al
    VH2+ Antigen-Experienced B Cells in the Cerebrospinal Fluid Are Expanded and Enriched in Pediatric Anti-NMDA Receptor Encephalitis.
    J Immunol. 2023;211:1332-1339.
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  75. AKBAR I, Tang R, Baillargeon J, Roy AP, et al
    Cutting Edge: Serpine1 Negatively Regulates Th1 Cell Responses in Experimental Autoimmune Encephalomyelitis.
    J Immunol. 2023 Nov 1:ji2300526. doi: 10.4049/jimmunol.2300526.
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  76. PELLERIN A, Tan Y, Lu S, Bonegio RG, et al
    Genetic Reduction of IRF5 Expression after Disease Initiation Reduces Disease in a Mouse Lupus Model by Impacting Systemic and End-Organ Pathogenic Pathways.
    J Immunol. 2023;211:1308-1319.
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    October 2023
  77. RACINE JJ, Misherghi A, Dwyer JR, Maser R, et al
    HLA-DQ8 Supports Development of Insulitis Mediated by Insulin-Reactive Human TCR-Transgenic T Cells in Nonobese Diabetic Mice.
    J Immunol. 2023 Oct 25:ji2300303. doi: 10.4049/jimmunol.2300303.
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  78. SOUKOU-WARGALLA S, Kilian C, Velasquez LN, Machicote A, et al
    Tr1 Cells Emerge and Suppress Effector Th17 Cells in Glomerulonephritis.
    J Immunol. 2023 Oct 18:ji2300305. doi: 10.4049/jimmunol.2300305.
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  79. JORDAN TJM, Chen J, Li N, Burette S, et al
    The Eotaxin-1/CCR3 Axis and Matrix Metalloproteinase-9 Are Critical in Anti-NC16A IgE-Induced Bullous Pemphigoid.
    J Immunol. 2023;211:1216-1223.
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  80. GILLES A, Hu L, Virdis F, Sant'Angelo DB, et al
    The MHC Class II Antigen-Processing and Presentation Pathway Is Dysregulated in Type 1 Diabetes.
    J Immunol. 2023 Oct 9:ji2300213. doi: 10.4049/jimmunol.2300213.
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  81. MOK MY, Luo CY, Huang FP, Kong WY, et al
    IL-33 Orchestrated the Interaction and Immunoregulatory Functions of Alternatively Activated Macrophages and Regulatory T Cells In Vitro.
    J Immunol. 2023;211:1134-1143.
    >> Share

    September 2023
  82. NEW JS, Dizon BLP, King RG, Greenspan NS, et al
    B-1 B Cell-Derived Natural Antibodies against N-Acetyl-d-Glucosamine Suppress Autoimmune Diabetes Pathogenesis.
    J Immunol. 2023 Sep 25:ji2300264. doi: 10.4049/jimmunol.2300264.
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  83. MORIN F, Singh N, Mdzomba JB, Dumas A, et al
    Correction: Conditional Deletions of Hdc Confirm Roles of Histamine in Anaphylaxis and Circadian Activity but Not in Autoimmune Encephalomyelitis.
    J Immunol. 2023 Sep 11:ji2300549. doi: 10.4049/jimmunol.2300549.
    >> Share


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