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Articles published in
Proc Natl Acad Sci U S A
    September 2023
  1. LOPES JR, Zhang X, Mayrink J, Tatematsu BK, et al
    Nasal administration of anti-CD3 monoclonal antibody ameliorates disease in a mouse model of Alzheimer's disease.
    Proc Natl Acad Sci U S A. 2023;120:e2309221120.
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  2. LE GUEN Y, Luo G, Ambati A, Damotte V, et al
    Multiancestry analysis of the HLA locus in Alzheimer's and Parkinson's diseases uncovers a shared adaptive immune response mediated by HLA-DRB1*04 subtypes.
    Proc Natl Acad Sci U S A. 2023;120:e2302720120.
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  3. CHEN ZL, Singh PK, Calvano M, Norris EH, et al
    A possible mechanism for the enhanced toxicity of beta-amyloid protofibrils in Alzheimer's disease.
    Proc Natl Acad Sci U S A. 2023;120:e2309389120.
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    August 2023
  4. SOULA M, Maslarova A, Harvey RE, Valero M, et al
    Interictal epileptiform discharges affect memory in an Alzheimer's disease mouse model.
    Proc Natl Acad Sci U S A. 2023;120:e2302676120.
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  5. NAKANO-KOBAYASHI A, Canela A, Yoshihara T, Hagiwara M, et al
    Astrocyte-targeting therapy rescues cognitive impairment caused by neuroinflammation via the Nrf2 pathway.
    Proc Natl Acad Sci U S A. 2023;120:e2303809120.
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    July 2023
  6. CAZZARO S, Woo JA, Wang X, Liu T, et al
    Slingshot homolog-1-mediated Nrf2 sequestration tips the balance from neuroprotection to neurodegeneration in Alzheimer's disease.
    Proc Natl Acad Sci U S A. 2023;120:e2217128120.
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    June 2023
  7. THACKER D, Barghouth M, Bless M, Zhang E, et al
    Direct observation of secondary nucleation along the fibril surface of the amyloid beta 42 peptide.
    Proc Natl Acad Sci U S A. 2023;120:e2220664120.
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  8. ENNERFELT H, Holliday C, Shapiro DA, Zengeler KE, et al
    CARD9 attenuates Abeta pathology and modifies microglial responses in an Alzheimer's disease mouse model.
    Proc Natl Acad Sci U S A. 2023;120:e2303760120.
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    May 2023
  9. KREUTZER AG, Guaglianone G, Yoo S, Parrocha CMT, et al
    Probing differences among Abeta oligomers with two triangular trimers derived from Abeta.
    Proc Natl Acad Sci U S A. 2023;120:e2219216120.
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  10. ZHOU GF, Tang J, Ma YL, Fu X, et al
    ARL6IP1 mediates small-molecule-induced alleviation of Alzheimer pathology through FXR1-dependent BACE1 translation initiation.
    Proc Natl Acad Sci U S A. 2023;120:e2220148120.
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  11. GHOSH S, Tugarinov V, Clore GM
    Quantitative NMR analysis of the mechanism and kinetics of chaperone Hsp104 action on amyloid-beta42 aggregation and fibril formation.
    Proc Natl Acad Sci U S A. 2023;120:e2305823120.
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  12. MILLER A, Wei J, Meehan S, Dobson CM, et al
    Formation of amyloid loops in brain tissues is controlled by the flexibility of protofibril chains.
    Proc Natl Acad Sci U S A. 2023;120:e2216234120.
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  13. CHEN W, Huang Q, Lazdon EK, Gomes A, et al
    Loss of insulin signaling in astrocytes exacerbates Alzheimer-like phenotypes in a 5xFAD mouse model.
    Proc Natl Acad Sci U S A. 2023;120:e2220684120.
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  14. YANG XK, Zhang FL, Jin XK, Jiao YT, et al
    Nanoelectrochemistry reveals how soluble Abeta(42) oligomers alter vesicular storage and release of glutamate.
    Proc Natl Acad Sci U S A. 2023;120:e2219994120.
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  15. HASSANI SA, Neumann A, Russell J, Jones CK, et al
    M(1)-selective muscarinic allosteric modulation enhances cognitive flexibility and effective salience in nonhuman primates.
    Proc Natl Acad Sci U S A. 2023;120:e2216792120.
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    March 2023
  16. CONDELLO C, Ayers JI, Dalgard CL, Garcia Garcia MM, et al
    Guam ALS-PDC is a distinct double-prion disorder featuring both tau and Abeta prions.
    Proc Natl Acad Sci U S A. 2023;120:e2220984120.
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  17. YANG H, Yuan P, Wu Y, Shi M, et al
    EMBER multidimensional spectral microscopy enables quantitative determination of disease- and cell-specific amyloid strains.
    Proc Natl Acad Sci U S A. 2023;120:e2300769120.
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  18. LEE M, Yau WM, Louis JM, Tycko R, et al
    Structures of brain-derived 42-residue amyloid-beta fibril polymorphs with unusual molecular conformations and intermolecular interactions.
    Proc Natl Acad Sci U S A. 2023;120:e2218831120.
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    February 2023
  19. CASTRO-HERNANDEZ R, Berulava T, Metelova M, Epple R, et al
    Conserved reduction of m(6)A RNA modifications during aging and neurodegeneration is linked to changes in synaptic transcripts.
    Proc Natl Acad Sci U S A. 2023;120:e2204933120.
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  20. FAIRLEY LH, Lai KO, Wong JH, Chong WJ, et al
    Mitochondrial control of microglial phagocytosis by the translocator protein and hexokinase 2 in Alzheimer's disease.
    Proc Natl Acad Sci U S A. 2023;120:e2209177120.
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  21. LIU YJ, Ding Y, Yin YQ, Xiao H, et al
    Cspg4(high) microglia contribute to microgliosis during neurodegeneration.
    Proc Natl Acad Sci U S A. 2023;120:e2210643120.
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  22. GOYAL MS, Blazey T, Metcalf NV, McAvoy MP, et al
    Brain aerobic glycolysis and resilience in Alzheimer disease.
    Proc Natl Acad Sci U S A. 2023;120:e2212256120.
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  23. QIU Y, Shen X, Ravid O, Atrakchi D, et al
    Definition of the contribution of an Osteopontin-producing CD11c(+) microglial subset to Alzheimer's disease.
    Proc Natl Acad Sci U S A. 2023;120:e2218915120.
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  24. STEINMAN L
    An intrinsically disordered protein, osteopontin, driving neuropathology in Alzheimer's dementia.
    Proc Natl Acad Sci U S A. 2023;120:e2221816120.
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  25. WANG R, Chaudhari P, Davatzikos C
    Bias in machine learning models can be significantly mitigated by careful training: Evidence from neuroimaging studies.
    Proc Natl Acad Sci U S A. 2023;120:e2211613120.
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    January 2023
  26. JENSEN AMG, Kitago Y, Fazeli E, Vaegter CB, et al
    Dimerization of the Alzheimer's disease pathogenic receptor SORLA regulates its association with retromer.
    Proc Natl Acad Sci U S A. 2023;120:e2212180120.
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  27. LESTER E, Van Alstyne M, McCann KL, Reddy S, et al
    Cytosolic condensates rich in polyserine define subcellular sites of tau aggregation.
    Proc Natl Acad Sci U S A. 2023;120:e2217759120.
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  28. PETERS A
    Ambient air pollution and Alzheimer's disease: the role of the composition of fine particles.
    Proc Natl Acad Sci U S A. 2023;120:e2220028120.
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  29. YIN C, Imms P, Cheng M, Amgalan A, et al
    Anatomically interpretable deep learning of brain age captures domain-specific cognitive impairment.
    Proc Natl Acad Sci U S A. 2023;120:e2214634120.
    >> Share

  30. ECK RJ, Kow RL, Black AH, Liachko NF, et al
    SPOP loss of function protects against tauopathy.
    Proc Natl Acad Sci U S A. 2023;120:e2207250120.
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    December 2022
  31. SHEA D, Colasurdo E, Smith A, Paschall C, et al
    SOBA: Development and testing of a soluble oligomer binding assay for detection of amyloidogenic toxic oligomers.
    Proc Natl Acad Sci U S A. 2022;119:e2213157119.
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  32. MUSTALY-KALIMI S, Gallegos W, Marr RA, Gilman-Sachs A, et al
    Protein mishandling and impaired lysosomal proteolysis generated through calcium dysregulation in Alzheimer's disease.
    Proc Natl Acad Sci U S A. 2022;119:e2211999119.
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  33. HABASHI M, Vutla S, Tripathi K, Senapati S, et al
    Early diagnosis and treatment of Alzheimer's disease by targeting toxic soluble Abeta oligomers.
    Proc Natl Acad Sci U S A. 2022;119:e2210766119.
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    November 2022
  34. CONDELLO C, Maxwell AM, Castillo E, Aoyagi A, et al
    Abeta and tau prions feature in the neuropathogenesis of Down syndrome.
    Proc Natl Acad Sci U S A. 2022;119:e2212954119.
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  35. DENG J, Ji Y, Zhu F, Liu L, et al
    Mapping secretome-mediated interaction between paired neuron-macrophage single cells.
    Proc Natl Acad Sci U S A. 2022;119:e2200944119.
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    October 2022
  36. DEHGHAN A, Pinto RC, Karaman I, Huang J, et al
    Metabolome-wide association study on ABCA7 indicates a role of ceramide metabolism in Alzheimer's disease.
    Proc Natl Acad Sci U S A. 2022;119:e2206083119.
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  37. WANG X, Rimal S, Tantray I, Geng J, et al
    Prevention of ribosome collision-induced neuromuscular degeneration by SARS CoV-2-encoded Nsp1.
    Proc Natl Acad Sci U S A. 2022;119:e2202322119.
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  38. HUANG Y, Lemke G
    Early death in a mouse model of Alzheimer's disease exacerbated by microglial loss of TAM receptor signaling.
    Proc Natl Acad Sci U S A. 2022;119:e2204306119.
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  39. HUANG Y, Rafael Guimaraes T, Todd N, Ferguson C, et al
    G protein-biased GPR3 signaling ameliorates amyloid pathology in a preclinical Alzheimer's disease mouse model.
    Proc Natl Acad Sci U S A. 2022;119:e2204828119.
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  40. TIAN J, Ren M, Zhao P, Luo S, et al
    Dissection of the long-range projections of specific neurons at the synaptic level in the whole mouse brain.
    Proc Natl Acad Sci U S A. 2022;119:e2202536119.
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    September 2022
  41. ORTI-CASAN N, Zuhorn IS, Naude PJW, De Deyn PP, et al
    A TNF receptor 2 agonist ameliorates neuropathology and improves cognition in an Alzheimer's disease mouse model.
    Proc Natl Acad Sci U S A. 2022;119:e2201137119.
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  42. NGIAN ZK, Tan YY, Choo CT, Lin WQ, et al
    Truncated Tau caused by intron retention is enriched in Alzheimer's disease cortex and exhibits altered biochemical properties.
    Proc Natl Acad Sci U S A. 2022;119:e2204179119.
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    August 2022
  43. SAROJA SR, Gorbachev K, Julia T, Goate AM, et al
    Astrocyte-secreted glypican-4 drives APOE4-dependent tau hyperphosphorylation.
    Proc Natl Acad Sci U S A. 2022;119:e2108870119.
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  44. MURRAY KA, Hu CJ, Griner SL, Pan H, et al
    De novo designed protein inhibitors of amyloid aggregation and seeding.
    Proc Natl Acad Sci U S A. 2022;119:e2206240119.
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    June 2022
  45. TAYLOR JL, Pritchard HAT, Walsh KR, Strangward P, et al
    Functionally linked potassium channel activity in cerebral endothelial and smooth muscle cells is compromised in Alzheimer's disease.
    Proc Natl Acad Sci U S A. 2022;119:e2204581119.
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  46. ENINGER T, Muller SA, Bacioglu M, Schweighauser M, et al
    Signatures of glial activity can be detected in the CSF proteome.
    Proc Natl Acad Sci U S A. 2022;119:e2119804119.
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    May 2022
  47. LINSE S, Sormanni P, O'Connell DJ
    An aggregation inhibitor specific to oligomeric intermediates of Abeta42 derived from phage display libraries of stable, small proteins.
    Proc Natl Acad Sci U S A. 2022;119:e2121966119.
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  48. ROGERS MA, Chang CCY, Maue RA, Melton EM, et al
    Acat1/Soat1 knockout extends the mutant Npc1 mouse lifespan and ameliorates functional deficiencies in multiple organelles of mutant cells.
    Proc Natl Acad Sci U S A. 2022;119:e2201646119.
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    April 2022
  49. GUZMAN-VELEZ E, Diez I, Schoemaker D, Pardilla-Delgado E, et al
    Amyloid-beta and tau pathologies relate to distinctive brain dysconnectomics in preclinical autosomal-dominant Alzheimer's disease.
    Proc Natl Acad Sci U S A. 2022;119:e2113641119.
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    March 2022
  50. JIN C, Wang J, Wang Y, Jia B, et al
    Modulation of amyloid precursor protein cleavage by gamma-secretase activating protein through phase separation.
    Proc Natl Acad Sci U S A. 2022;119:e2122292119.
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  51. SHIGEMORI K, Nomura S, Umeda T, Takeda S, et al
    Peripheral Abeta acts as a negative modulator of insulin secretion.
    Proc Natl Acad Sci U S A. 2022;119:e2117723119.
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    February 2022
  52. BELSARE KD, Wu H, Mondal D, Bond A, et al
    Soluble TREM2 inhibits secondary nucleation of Abeta fibrillization and enhances cellular uptake of fibrillar Abeta.
    Proc Natl Acad Sci U S A. 2022;119.
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    January 2022
  53. PARK MH, Park KH, Choi BJ, Han WH, et al
    Discovery of a dual-action small molecule that improves neuropathological features of Alzheimer's disease mice.
    Proc Natl Acad Sci U S A. 2022;119.
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    December 2021
  54. MOULTON MJ, Barish S, Ralhan I, Chang J, et al
    Neuronal ROS-induced glial lipid droplet formation is altered by loss of Alzheimer's disease-associated genes.
    Proc Natl Acad Sci U S A. 2021;118.
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    November 2021
  55. LATTANZI V, Andre I, Gasser U, Dubackic M, et al
    Amyloid beta 42 fibril structure based on small-angle scattering.
    Proc Natl Acad Sci U S A. 2021;118.
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  56. PALMER CR, Liu CS, Romanow WJ, Lee MH, et al
    Altered cell and RNA isoform diversity in aging Down syndrome brains.
    Proc Natl Acad Sci U S A. 2021;118.
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  57. GHOSH U, Yau WM, Collinge J, Tycko R, et al
    Structural differences in amyloid-beta fibrils from brains of nondemented elderly individuals and Alzheimer's disease patients.
    Proc Natl Acad Sci U S A. 2021;118.
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    October 2021

  58. Correction for Sen et al., Sulfhydration of AKT triggers Tau-phosphorylation by activating glycogen synthase kinase 3beta in Alzheimer's disease.
    Proc Natl Acad Sci U S A. 2021;118.
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  59. PARKHITKO AA, Wang L, Filine E, Jouandin P, et al
    A genetic model of methionine restriction extends Drosophila health- and lifespan.
    Proc Natl Acad Sci U S A. 2021;118.
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    September 2021
  60. HOU Y, Wei Y, Lautrup S, Yang B, et al
    NAD(+) supplementation reduces neuroinflammation and cell senescence in a transgenic mouse model of Alzheimer's disease via cGAS-STING.
    Proc Natl Acad Sci U S A. 2021;118.
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    August 2021

  61. Correction for Sun et al., Selective filtering defect at the axon initial segment in Alzheimer's disease mouse models.
    Proc Natl Acad Sci U S A. 2021;118.
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    July 2021
  62. WANG H, Robinson JL, Kocabas P, Gustafsson J, et al
    Genome-scale metabolic network reconstruction of model animals as a platform for translational research.
    Proc Natl Acad Sci U S A. 2021;118.
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    June 2021
  63. WU Z, Chen C, Kang SS, Liu X, et al
    Neurotrophic signaling deficiency exacerbates environmental risks for Alzheimer's disease pathogenesis.
    Proc Natl Acad Sci U S A. 2021;118.
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  64. SADE YAZDI D, Laor Bar-Yosef D, Adsi H, Kreiser T, et al
    Homocysteine fibrillar assemblies display cross-talk with Alzheimer's disease beta-amyloid polypeptide.
    Proc Natl Acad Sci U S A. 2021;118.
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    April 2021
  65. LORD J, Jermy B, Green R, Wong A, et al
    Mendelian randomization identifies blood metabolites previously linked to midlife cognition as causal candidates in Alzheimer's disease.
    Proc Natl Acad Sci U S A. 2021;118.
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    March 2021
  66. IPPATI S, Deng Y, van der Hoven J, Heu C, et al
    Rapid initiation of cell cycle reentry processes protects neurons from amyloid-beta toxicity.
    Proc Natl Acad Sci U S A. 2021;118.
    >> Share

  67. RAMESHA S, Rayaprolu S, Bowen CA, Giver CR, et al
    Unique molecular characteristics and microglial origin of Kv1.3 channel-positive brain myeloid cells in Alzheimer's disease.
    Proc Natl Acad Sci U S A. 2021;118.
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  68. Correction for Kim et al., Prediction of Alzheimer's disease-specific phospholipase c gamma-1 SNV by deep learning-based approach for high-throughput screening.
    Proc Natl Acad Sci U S A. 2021;118.
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    January 2021
  69. GHOSH U, Thurber KR, Yau WM, Tycko R, et al
    Molecular structure of a prevalent amyloid-beta fibril polymorph from Alzheimer's disease brain tissue.
    Proc Natl Acad Sci U S A. 2021;118.
    >> Share

  70. GIOVINAZZO D, Bursac B, Sbodio JI, Nalluru S, et al
    Hydrogen sulfide is neuroprotective in Alzheimer's disease by sulfhydrating GSK3beta and inhibiting Tau hyperphosphorylation.
    Proc Natl Acad Sci U S A. 2021;118.
    >> Share

  71. AHMED F
    QnAs with Robert Tycko.
    Proc Natl Acad Sci U S A. 2021;118.
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  72. KIM SH, Yang S, Lim KH, Ko E, et al
    Prediction of Alzheimer's disease-specific phospholipase c gamma-1 SNV by deep learning-based approach for high-throughput screening.
    Proc Natl Acad Sci U S A. 2021;118.
    >> Share

  73. ELLWANGER DC, Wang S, Brioschi S, Shao Z, et al
    Prior activation state shapes the microglia response to antihuman TREM2 in a mouse model of Alzheimer's disease.
    Proc Natl Acad Sci U S A. 2021;118.
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    December 2020
  74. LOHR KM, Frost B, Scherzer C, Feany MB, et al
    Biotin rescues mitochondrial dysfunction and neurotoxicity in a tauopathy model.
    Proc Natl Acad Sci U S A. 2020;117:33608-33618.
    >> Share

  75. BOYKO S, Surewicz K, Surewicz WK
    Regulatory mechanisms of tau protein fibrillation under the conditions of liquid-liquid phase separation.
    Proc Natl Acad Sci U S A. 2020;117:31882-31890.
    >> Share

  76. SWANSON LW, Hahn JD, Sporns O
    Structure-function subsystem models of female and male forebrain networks integrating cognition, affect, behavior, and bodily functions.
    Proc Natl Acad Sci U S A. 2020;117:31470-31481.
    >> Share

  77. DUBEY S, Heinen S, Krantic S, McLaurin J, et al
    Clinically approved IVIg delivered to the hippocampus with focused ultrasound promotes neurogenesis in a model of Alzheimer's disease.
    Proc Natl Acad Sci U S A. 2020 Dec 7. pii: 1908658117.
    >> Share

    November 2020
  78. LONNEMANN N, Hosseini S, Marchetti C, Skouras DB, et al
    The NLRP3 inflammasome inhibitor OLT1177 rescues cognitive impairment in a mouse model of Alzheimer's disease.
    Proc Natl Acad Sci U S A. 2020 Nov 30. pii: 2009680117.
    >> Share

  79. CHO HJ, Huynh TT, Rogers BE, Mirica LM, et al
    Design of a multivalent bifunctional chelator for diagnostic (64)Cu PET imaging in Alzheimer's disease.
    Proc Natl Acad Sci U S A. 2020 Nov 24. pii: 2014058117.
    >> Share

  80. ENGSTROM AK, Walker AC, Moudgal RA, Myrick DA, et al
    The inhibition of LSD1 via sequestration contributes to tau-mediated neurodegeneration.
    Proc Natl Acad Sci U S A. 2020;117:29133-29143.
    >> Share

    October 2020

  81. Correction for Bao et al., BACE1 SUMOylation increases its stability and escalates the protease activity in Alzheimer's disease.
    Proc Natl Acad Sci U S A. 2020 Oct 26. pii: 2019837117.
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    September 2020
  82. LAU SF, Cao H, Fu AKY, Ip NY, et al
    Single-nucleus transcriptome analysis reveals dysregulation of angiogenic endothelial cells and neuroprotective glia in Alzheimer's disease.
    Proc Natl Acad Sci U S A. 2020 Sep 28. pii: 2008762117.
    >> Share

    August 2020
  83. O'CONNELL GC, Alder ML, Smothers CG, Chang JHC, et al
    Large-scale informatic analysis to algorithmically identify blood biomarkers of neurological damage.
    Proc Natl Acad Sci U S A. 2020;117:20764-20775.
    >> Share

  84. CHAKRABORTY D, Straub JE, Thirumalai D
    Differences in the free energies between the excited states of Abeta40 and Abeta42 monomers encode their aggregation propensities.
    Proc Natl Acad Sci U S A. 2020;117:19926-19937.
    >> Share


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