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Articles published in
Proc Natl Acad Sci U S A
    November 2021
  1. GHOSH U, Yau WM, Collinge J, Tycko R, et al
    Structural differences in amyloid-beta fibrils from brains of nondemented elderly individuals and Alzheimer's disease patients.
    Proc Natl Acad Sci U S A. 2021;118.
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    October 2021

  2. Correction for Sen et al., Sulfhydration of AKT triggers Tau-phosphorylation by activating glycogen synthase kinase 3beta in Alzheimer's disease.
    Proc Natl Acad Sci U S A. 2021;118.
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    September 2021
  3. HOU Y, Wei Y, Lautrup S, Yang B, et al
    NAD(+) supplementation reduces neuroinflammation and cell senescence in a transgenic mouse model of Alzheimer's disease via cGAS-STING.
    Proc Natl Acad Sci U S A. 2021;118.
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    August 2021

  4. Correction for Sun et al., Selective filtering defect at the axon initial segment in Alzheimer's disease mouse models.
    Proc Natl Acad Sci U S A. 2021;118.
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    June 2021
  5. WU Z, Chen C, Kang SS, Liu X, et al
    Neurotrophic signaling deficiency exacerbates environmental risks for Alzheimer's disease pathogenesis.
    Proc Natl Acad Sci U S A. 2021;118.
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  6. SADE YAZDI D, Laor Bar-Yosef D, Adsi H, Kreiser T, et al
    Homocysteine fibrillar assemblies display cross-talk with Alzheimer's disease beta-amyloid polypeptide.
    Proc Natl Acad Sci U S A. 2021;118.
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    April 2021
  7. LORD J, Jermy B, Green R, Wong A, et al
    Mendelian randomization identifies blood metabolites previously linked to midlife cognition as causal candidates in Alzheimer's disease.
    Proc Natl Acad Sci U S A. 2021;118.
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    March 2021
  8. IPPATI S, Deng Y, van der Hoven J, Heu C, et al
    Rapid initiation of cell cycle reentry processes protects neurons from amyloid-beta toxicity.
    Proc Natl Acad Sci U S A. 2021;118.
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  9. RAMESHA S, Rayaprolu S, Bowen CA, Giver CR, et al
    Unique molecular characteristics and microglial origin of Kv1.3 channel-positive brain myeloid cells in Alzheimer's disease.
    Proc Natl Acad Sci U S A. 2021;118.
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  10. Correction for Kim et al., Prediction of Alzheimer's disease-specific phospholipase c gamma-1 SNV by deep learning-based approach for high-throughput screening.
    Proc Natl Acad Sci U S A. 2021;118.
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    January 2021
  11. GHOSH U, Thurber KR, Yau WM, Tycko R, et al
    Molecular structure of a prevalent amyloid-beta fibril polymorph from Alzheimer's disease brain tissue.
    Proc Natl Acad Sci U S A. 2021;118.
    >> Share

  12. GIOVINAZZO D, Bursac B, Sbodio JI, Nalluru S, et al
    Hydrogen sulfide is neuroprotective in Alzheimer's disease by sulfhydrating GSK3beta and inhibiting Tau hyperphosphorylation.
    Proc Natl Acad Sci U S A. 2021;118.
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  13. AHMED F
    QnAs with Robert Tycko.
    Proc Natl Acad Sci U S A. 2021;118.
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  14. KIM SH, Yang S, Lim KH, Ko E, et al
    Prediction of Alzheimer's disease-specific phospholipase c gamma-1 SNV by deep learning-based approach for high-throughput screening.
    Proc Natl Acad Sci U S A. 2021;118.
    >> Share

  15. ELLWANGER DC, Wang S, Brioschi S, Shao Z, et al
    Prior activation state shapes the microglia response to antihuman TREM2 in a mouse model of Alzheimer's disease.
    Proc Natl Acad Sci U S A. 2021;118.
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    December 2020
  16. LOHR KM, Frost B, Scherzer C, Feany MB, et al
    Biotin rescues mitochondrial dysfunction and neurotoxicity in a tauopathy model.
    Proc Natl Acad Sci U S A. 2020;117:33608-33618.
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  17. BOYKO S, Surewicz K, Surewicz WK
    Regulatory mechanisms of tau protein fibrillation under the conditions of liquid-liquid phase separation.
    Proc Natl Acad Sci U S A. 2020;117:31882-31890.
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  18. SWANSON LW, Hahn JD, Sporns O
    Structure-function subsystem models of female and male forebrain networks integrating cognition, affect, behavior, and bodily functions.
    Proc Natl Acad Sci U S A. 2020;117:31470-31481.
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  19. DUBEY S, Heinen S, Krantic S, McLaurin J, et al
    Clinically approved IVIg delivered to the hippocampus with focused ultrasound promotes neurogenesis in a model of Alzheimer's disease.
    Proc Natl Acad Sci U S A. 2020 Dec 7. pii: 1908658117.
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    November 2020
  20. LONNEMANN N, Hosseini S, Marchetti C, Skouras DB, et al
    The NLRP3 inflammasome inhibitor OLT1177 rescues cognitive impairment in a mouse model of Alzheimer's disease.
    Proc Natl Acad Sci U S A. 2020 Nov 30. pii: 2009680117.
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  21. CHO HJ, Huynh TT, Rogers BE, Mirica LM, et al
    Design of a multivalent bifunctional chelator for diagnostic (64)Cu PET imaging in Alzheimer's disease.
    Proc Natl Acad Sci U S A. 2020 Nov 24. pii: 2014058117.
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  22. ENGSTROM AK, Walker AC, Moudgal RA, Myrick DA, et al
    The inhibition of LSD1 via sequestration contributes to tau-mediated neurodegeneration.
    Proc Natl Acad Sci U S A. 2020;117:29133-29143.
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    October 2020

  23. Correction for Bao et al., BACE1 SUMOylation increases its stability and escalates the protease activity in Alzheimer's disease.
    Proc Natl Acad Sci U S A. 2020 Oct 26. pii: 2019837117.
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    September 2020
  24. LAU SF, Cao H, Fu AKY, Ip NY, et al
    Single-nucleus transcriptome analysis reveals dysregulation of angiogenic endothelial cells and neuroprotective glia in Alzheimer's disease.
    Proc Natl Acad Sci U S A. 2020 Sep 28. pii: 2008762117.
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    August 2020
  25. O'CONNELL GC, Alder ML, Smothers CG, Chang JHC, et al
    Large-scale informatic analysis to algorithmically identify blood biomarkers of neurological damage.
    Proc Natl Acad Sci U S A. 2020;117:20764-20775.
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  26. CHAKRABORTY D, Straub JE, Thirumalai D
    Differences in the free energies between the excited states of Abeta40 and Abeta42 monomers encode their aggregation propensities.
    Proc Natl Acad Sci U S A. 2020;117:19926-19937.
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    July 2020
  27. PEEPLES L
    Inner Workings: A pulse of hope in the fight against Alzheimer's.
    Proc Natl Acad Sci U S A. 2020 Jul 15. pii: 2013084117.
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    June 2020
  28. APRILE FA, Sormanni P, Podpolny M, Chhangur S, et al
    Rational design of a conformation-specific antibody for the quantification of Abeta oligomers.
    Proc Natl Acad Sci U S A. 2020;117:13509-13518.
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  29. DEAR AJ, Michaels TCT, Meisl G, Klenerman D, et al
    Kinetic diversity of amyloid oligomers.
    Proc Natl Acad Sci U S A. 2020;117:12087-12094.
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    May 2020
  30. TORNQUIST M, Cukalevski R, Weininger U, Meisl G, et al
    Ultrastructural evidence for self-replication of Alzheimer-associated Abeta42 amyloid along the sides of fibrils.
    Proc Natl Acad Sci U S A. 2020;117:11265-11273.
    >> Share

    April 2020
  31. REZAI AR, Ranjan M, D'Haese PF, Haut MW, et al
    Noninvasive hippocampal blood-brain barrier opening in Alzheimer's disease with focused ultrasound.
    Proc Natl Acad Sci U S A. 2020 Apr 13. pii: 2002571117.
    >> Share

  32. WERNER ER, Keller MA, Sailer S, Lackner K, et al
    The TMEM189 gene encodes plasmanylethanolamine desaturase which introduces the characteristic vinyl ether double bond into plasmalogens.
    Proc Natl Acad Sci U S A. 2020;117:7792-7798.
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    March 2020
  33. CENDROWSKA U, Silva PJ, Ait-Bouziad N, Muller M, et al
    Unraveling the complexity of amyloid polymorphism using gold nanoparticles and cryo-EM.
    Proc Natl Acad Sci U S A. 2020;117:6866-6874.
    >> Share

  34. WELIKOVITCH LA, Do Carmo S, Magloczky Z, Malcolm JC, et al
    Early intraneuronal amyloid triggers neuron-derived inflammatory signaling in APP transgenic rats and human brain.
    Proc Natl Acad Sci U S A. 2020;117:6844-6854.
    >> Share

  35. WOO JA, Liu T, Fang CC, Castano MA, et al
    beta-Arrestin2 oligomers impair the clearance of pathological tau and increase tau aggregates.
    Proc Natl Acad Sci U S A. 2020;117:5006-5015.
    >> Share

  36. CHOI JH, Han J, Theodoropoulos PC, Zhong X, et al
    Essential requirement for nicastrin in marginal zone and B-1 B cell development.
    Proc Natl Acad Sci U S A. 2020;117:4894-4901.
    >> Share

    February 2020
  37. SEN T, Saha P, Jiang T, Sen N, et al
    Sulfhydration of AKT triggers Tau-phosphorylation by activating glycogen synthase kinase 3beta in Alzheimer's disease.
    Proc Natl Acad Sci U S A. 2020 Feb 12. pii: 1916895117.
    >> Share

  38. PENG J, Zhao T
    Reduction in TOM1 expression exacerbates Alzheimer's disease.
    Proc Natl Acad Sci U S A. 2020 Feb 11. pii: 1917589117.
    >> Share

  39. MARTINI AC, Baglietto-Vargas D, Medeiros R, LaFerla FM, et al
    Reply to Peng and Zhao: Loss of endocytic protein TOM1 in Alzheimer's disease.
    Proc Natl Acad Sci U S A. 2020 Feb 11. pii: 1917743117.
    >> Share

    December 2019
  40. HAQUE RU, Levey AI
    Alzheimer's disease: A clinical perspective and future nonhuman primate research opportunities.
    Proc Natl Acad Sci U S A. 2019 Dec 23. pii: 1912954116.
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  41. ARNSTEN AFT, Datta D, Leslie S, Yang ST, et al
    Alzheimer's-like pathology in aging rhesus macaques: Unique opportunity to study the etiology and treatment of Alzheimer's disease.
    Proc Natl Acad Sci U S A. 2019 Dec 23. pii: 1903671116.
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  42. Correction for Wang et al., Spatiotemporal activation of the C/EBPbeta/delta-secretase axis regulates the pathogenesis of Alzheimer's disease.
    Proc Natl Acad Sci U S A. 2019 Dec 9. pii: 1920626117.
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    November 2019
  43. AIKAWA T, Ren Y, Yamazaki Y, Tachibana M, et al
    ABCA7 haplodeficiency disturbs microglial immune responses in the mouse brain.
    Proc Natl Acad Sci U S A. 2019;116:23790-23796.
    >> Share

  44. PARK MH, Lee M, Nam G, Kim M, et al
    N,N'-Diacetyl-p-phenylenediamine restores microglial phagocytosis and improves cognitive defects in Alzheimer's disease transgenic mice.
    Proc Natl Acad Sci U S A. 2019 Nov 4. pii: 1916318116.
    >> Share

    October 2019
  45. CHEN ZL, Singh P, Wong J, Horn K, et al
    An antibody against HK blocks Alzheimer's disease peptide beta-amyloid-induced bradykinin release in human plasma.
    Proc Natl Acad Sci U S A. 2019 Oct 28. pii: 1914831116.
    >> Share

  46. SHARMA A, Kazim SF, Larson CS, Ramakrishnan A, et al
    Divergent roles of astrocytic versus neuronal EAAT2 deficiency on cognition and overlap with aging and Alzheimer's molecular signatures.
    Proc Natl Acad Sci U S A. 2019 Oct 7. pii: 1903566116.
    >> Share

    August 2019
  47. LOPEZ T, Mustafa Z, Chen C, Lee KB, et al
    Functional selection of protease inhibitory antibodies.
    Proc Natl Acad Sci U S A. 2019;116:16314-16319.
    >> Share

  48. DREGNI AJ, Mandala VS, Wu H, Elkins MR, et al
    In vitro 0N4R tau fibrils contain a monomorphic beta-sheet core enclosed by dynamically heterogeneous fuzzy coat segments.
    Proc Natl Acad Sci U S A. 2019;116:16357-16366.
    >> Share

    July 2019
  49. MICHAELS TCT, Weber CA, Mahadevan L
    Optimal control strategies for inhibition of protein aggregation.
    Proc Natl Acad Sci U S A. 2019;116:14593-14598.
    >> Share

    June 2019
  50. HU ZW, Vugmeyster L, Au DF, Ostrovsky D, et al
    Molecular structure of an N-terminal phosphorylated beta-amyloid fibril.
    Proc Natl Acad Sci U S A. 2019;116:11253-11258.
    >> Share


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