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Alzheimer's Disease
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Articles published in
Proc Natl Acad Sci U S A
    October 2022
  1. HUANG Y, Rafael Guimaraes T, Todd N, Ferguson C, et al
    G protein-biased GPR3 signaling ameliorates amyloid pathology in a preclinical Alzheimer's disease mouse model.
    Proc Natl Acad Sci U S A. 2022;119:e2204828119.
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  2. TIAN J, Ren M, Zhao P, Luo S, et al
    Dissection of the long-range projections of specific neurons at the synaptic level in the whole mouse brain.
    Proc Natl Acad Sci U S A. 2022;119:e2202536119.
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    September 2022
  3. ORTI-CASAN N, Zuhorn IS, Naude PJW, De Deyn PP, et al
    A TNF receptor 2 agonist ameliorates neuropathology and improves cognition in an Alzheimer's disease mouse model.
    Proc Natl Acad Sci U S A. 2022;119:e2201137119.
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  4. NGIAN ZK, Tan YY, Choo CT, Lin WQ, et al
    Truncated Tau caused by intron retention is enriched in Alzheimer's disease cortex and exhibits altered biochemical properties.
    Proc Natl Acad Sci U S A. 2022;119:e2204179119.
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    August 2022
  5. SAROJA SR, Gorbachev K, Julia T, Goate AM, et al
    Astrocyte-secreted glypican-4 drives APOE4-dependent tau hyperphosphorylation.
    Proc Natl Acad Sci U S A. 2022;119:e2108870119.
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  6. MURRAY KA, Hu CJ, Griner SL, Pan H, et al
    De novo designed protein inhibitors of amyloid aggregation and seeding.
    Proc Natl Acad Sci U S A. 2022;119:e2206240119.
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    June 2022
  7. TAYLOR JL, Pritchard HAT, Walsh KR, Strangward P, et al
    Functionally linked potassium channel activity in cerebral endothelial and smooth muscle cells is compromised in Alzheimer's disease.
    Proc Natl Acad Sci U S A. 2022;119:e2204581119.
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  8. ENINGER T, Muller SA, Bacioglu M, Schweighauser M, et al
    Signatures of glial activity can be detected in the CSF proteome.
    Proc Natl Acad Sci U S A. 2022;119:e2119804119.
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    May 2022
  9. LINSE S, Sormanni P, O'Connell DJ
    An aggregation inhibitor specific to oligomeric intermediates of Abeta42 derived from phage display libraries of stable, small proteins.
    Proc Natl Acad Sci U S A. 2022;119:e2121966119.
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  10. ROGERS MA, Chang CCY, Maue RA, Melton EM, et al
    Acat1/Soat1 knockout extends the mutant Npc1 mouse lifespan and ameliorates functional deficiencies in multiple organelles of mutant cells.
    Proc Natl Acad Sci U S A. 2022;119:e2201646119.
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    April 2022
  11. GUZMAN-VELEZ E, Diez I, Schoemaker D, Pardilla-Delgado E, et al
    Amyloid-beta and tau pathologies relate to distinctive brain dysconnectomics in preclinical autosomal-dominant Alzheimer's disease.
    Proc Natl Acad Sci U S A. 2022;119:e2113641119.
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    March 2022
  12. JIN C, Wang J, Wang Y, Jia B, et al
    Modulation of amyloid precursor protein cleavage by gamma-secretase activating protein through phase separation.
    Proc Natl Acad Sci U S A. 2022;119:e2122292119.
    >> Share

  13. SHIGEMORI K, Nomura S, Umeda T, Takeda S, et al
    Peripheral Abeta acts as a negative modulator of insulin secretion.
    Proc Natl Acad Sci U S A. 2022;119:e2117723119.
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    February 2022
  14. BELSARE KD, Wu H, Mondal D, Bond A, et al
    Soluble TREM2 inhibits secondary nucleation of Abeta fibrillization and enhances cellular uptake of fibrillar Abeta.
    Proc Natl Acad Sci U S A. 2022;119.
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    January 2022
  15. PARK MH, Park KH, Choi BJ, Han WH, et al
    Discovery of a dual-action small molecule that improves neuropathological features of Alzheimer's disease mice.
    Proc Natl Acad Sci U S A. 2022;119.
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    December 2021
  16. MOULTON MJ, Barish S, Ralhan I, Chang J, et al
    Neuronal ROS-induced glial lipid droplet formation is altered by loss of Alzheimer's disease-associated genes.
    Proc Natl Acad Sci U S A. 2021;118.
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    November 2021
  17. LATTANZI V, Andre I, Gasser U, Dubackic M, et al
    Amyloid beta 42 fibril structure based on small-angle scattering.
    Proc Natl Acad Sci U S A. 2021;118.
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  18. PALMER CR, Liu CS, Romanow WJ, Lee MH, et al
    Altered cell and RNA isoform diversity in aging Down syndrome brains.
    Proc Natl Acad Sci U S A. 2021;118.
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  19. GHOSH U, Yau WM, Collinge J, Tycko R, et al
    Structural differences in amyloid-beta fibrils from brains of nondemented elderly individuals and Alzheimer's disease patients.
    Proc Natl Acad Sci U S A. 2021;118.
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    October 2021

  20. Correction for Sen et al., Sulfhydration of AKT triggers Tau-phosphorylation by activating glycogen synthase kinase 3beta in Alzheimer's disease.
    Proc Natl Acad Sci U S A. 2021;118.
    >> Share

  21. PARKHITKO AA, Wang L, Filine E, Jouandin P, et al
    A genetic model of methionine restriction extends Drosophila health- and lifespan.
    Proc Natl Acad Sci U S A. 2021;118.
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    September 2021
  22. HOU Y, Wei Y, Lautrup S, Yang B, et al
    NAD(+) supplementation reduces neuroinflammation and cell senescence in a transgenic mouse model of Alzheimer's disease via cGAS-STING.
    Proc Natl Acad Sci U S A. 2021;118.
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    August 2021

  23. Correction for Sun et al., Selective filtering defect at the axon initial segment in Alzheimer's disease mouse models.
    Proc Natl Acad Sci U S A. 2021;118.
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    July 2021
  24. WANG H, Robinson JL, Kocabas P, Gustafsson J, et al
    Genome-scale metabolic network reconstruction of model animals as a platform for translational research.
    Proc Natl Acad Sci U S A. 2021;118.
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    June 2021
  25. WU Z, Chen C, Kang SS, Liu X, et al
    Neurotrophic signaling deficiency exacerbates environmental risks for Alzheimer's disease pathogenesis.
    Proc Natl Acad Sci U S A. 2021;118.
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  26. SADE YAZDI D, Laor Bar-Yosef D, Adsi H, Kreiser T, et al
    Homocysteine fibrillar assemblies display cross-talk with Alzheimer's disease beta-amyloid polypeptide.
    Proc Natl Acad Sci U S A. 2021;118.
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    April 2021
  27. LORD J, Jermy B, Green R, Wong A, et al
    Mendelian randomization identifies blood metabolites previously linked to midlife cognition as causal candidates in Alzheimer's disease.
    Proc Natl Acad Sci U S A. 2021;118.
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    March 2021
  28. IPPATI S, Deng Y, van der Hoven J, Heu C, et al
    Rapid initiation of cell cycle reentry processes protects neurons from amyloid-beta toxicity.
    Proc Natl Acad Sci U S A. 2021;118.
    >> Share

  29. RAMESHA S, Rayaprolu S, Bowen CA, Giver CR, et al
    Unique molecular characteristics and microglial origin of Kv1.3 channel-positive brain myeloid cells in Alzheimer's disease.
    Proc Natl Acad Sci U S A. 2021;118.
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  30. Correction for Kim et al., Prediction of Alzheimer's disease-specific phospholipase c gamma-1 SNV by deep learning-based approach for high-throughput screening.
    Proc Natl Acad Sci U S A. 2021;118.
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    January 2021
  31. GHOSH U, Thurber KR, Yau WM, Tycko R, et al
    Molecular structure of a prevalent amyloid-beta fibril polymorph from Alzheimer's disease brain tissue.
    Proc Natl Acad Sci U S A. 2021;118.
    >> Share

  32. GIOVINAZZO D, Bursac B, Sbodio JI, Nalluru S, et al
    Hydrogen sulfide is neuroprotective in Alzheimer's disease by sulfhydrating GSK3beta and inhibiting Tau hyperphosphorylation.
    Proc Natl Acad Sci U S A. 2021;118.
    >> Share

  33. AHMED F
    QnAs with Robert Tycko.
    Proc Natl Acad Sci U S A. 2021;118.
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  34. KIM SH, Yang S, Lim KH, Ko E, et al
    Prediction of Alzheimer's disease-specific phospholipase c gamma-1 SNV by deep learning-based approach for high-throughput screening.
    Proc Natl Acad Sci U S A. 2021;118.
    >> Share

  35. ELLWANGER DC, Wang S, Brioschi S, Shao Z, et al
    Prior activation state shapes the microglia response to antihuman TREM2 in a mouse model of Alzheimer's disease.
    Proc Natl Acad Sci U S A. 2021;118.
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    December 2020
  36. LOHR KM, Frost B, Scherzer C, Feany MB, et al
    Biotin rescues mitochondrial dysfunction and neurotoxicity in a tauopathy model.
    Proc Natl Acad Sci U S A. 2020;117:33608-33618.
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  37. BOYKO S, Surewicz K, Surewicz WK
    Regulatory mechanisms of tau protein fibrillation under the conditions of liquid-liquid phase separation.
    Proc Natl Acad Sci U S A. 2020;117:31882-31890.
    >> Share

  38. SWANSON LW, Hahn JD, Sporns O
    Structure-function subsystem models of female and male forebrain networks integrating cognition, affect, behavior, and bodily functions.
    Proc Natl Acad Sci U S A. 2020;117:31470-31481.
    >> Share

  39. DUBEY S, Heinen S, Krantic S, McLaurin J, et al
    Clinically approved IVIg delivered to the hippocampus with focused ultrasound promotes neurogenesis in a model of Alzheimer's disease.
    Proc Natl Acad Sci U S A. 2020 Dec 7. pii: 1908658117.
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    November 2020
  40. LONNEMANN N, Hosseini S, Marchetti C, Skouras DB, et al
    The NLRP3 inflammasome inhibitor OLT1177 rescues cognitive impairment in a mouse model of Alzheimer's disease.
    Proc Natl Acad Sci U S A. 2020 Nov 30. pii: 2009680117.
    >> Share

  41. CHO HJ, Huynh TT, Rogers BE, Mirica LM, et al
    Design of a multivalent bifunctional chelator for diagnostic (64)Cu PET imaging in Alzheimer's disease.
    Proc Natl Acad Sci U S A. 2020 Nov 24. pii: 2014058117.
    >> Share

  42. ENGSTROM AK, Walker AC, Moudgal RA, Myrick DA, et al
    The inhibition of LSD1 via sequestration contributes to tau-mediated neurodegeneration.
    Proc Natl Acad Sci U S A. 2020;117:29133-29143.
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    October 2020

  43. Correction for Bao et al., BACE1 SUMOylation increases its stability and escalates the protease activity in Alzheimer's disease.
    Proc Natl Acad Sci U S A. 2020 Oct 26. pii: 2019837117.
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    September 2020
  44. LAU SF, Cao H, Fu AKY, Ip NY, et al
    Single-nucleus transcriptome analysis reveals dysregulation of angiogenic endothelial cells and neuroprotective glia in Alzheimer's disease.
    Proc Natl Acad Sci U S A. 2020 Sep 28. pii: 2008762117.
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    August 2020
  45. O'CONNELL GC, Alder ML, Smothers CG, Chang JHC, et al
    Large-scale informatic analysis to algorithmically identify blood biomarkers of neurological damage.
    Proc Natl Acad Sci U S A. 2020;117:20764-20775.
    >> Share

  46. CHAKRABORTY D, Straub JE, Thirumalai D
    Differences in the free energies between the excited states of Abeta40 and Abeta42 monomers encode their aggregation propensities.
    Proc Natl Acad Sci U S A. 2020;117:19926-19937.
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    July 2020
  47. PEEPLES L
    Inner Workings: A pulse of hope in the fight against Alzheimer's.
    Proc Natl Acad Sci U S A. 2020 Jul 15. pii: 2013084117.
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    June 2020
  48. APRILE FA, Sormanni P, Podpolny M, Chhangur S, et al
    Rational design of a conformation-specific antibody for the quantification of Abeta oligomers.
    Proc Natl Acad Sci U S A. 2020;117:13509-13518.
    >> Share

  49. DEAR AJ, Michaels TCT, Meisl G, Klenerman D, et al
    Kinetic diversity of amyloid oligomers.
    Proc Natl Acad Sci U S A. 2020;117:12087-12094.
    >> Share

    May 2020
  50. TORNQUIST M, Cukalevski R, Weininger U, Meisl G, et al
    Ultrastructural evidence for self-replication of Alzheimer-associated Abeta42 amyloid along the sides of fibrils.
    Proc Natl Acad Sci U S A. 2020;117:11265-11273.
    >> Share

    April 2020
  51. REZAI AR, Ranjan M, D'Haese PF, Haut MW, et al
    Noninvasive hippocampal blood-brain barrier opening in Alzheimer's disease with focused ultrasound.
    Proc Natl Acad Sci U S A. 2020 Apr 13. pii: 2002571117.
    >> Share

  52. WERNER ER, Keller MA, Sailer S, Lackner K, et al
    The TMEM189 gene encodes plasmanylethanolamine desaturase which introduces the characteristic vinyl ether double bond into plasmalogens.
    Proc Natl Acad Sci U S A. 2020;117:7792-7798.
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    March 2020
  53. CENDROWSKA U, Silva PJ, Ait-Bouziad N, Muller M, et al
    Unraveling the complexity of amyloid polymorphism using gold nanoparticles and cryo-EM.
    Proc Natl Acad Sci U S A. 2020;117:6866-6874.
    >> Share

  54. WELIKOVITCH LA, Do Carmo S, Magloczky Z, Malcolm JC, et al
    Early intraneuronal amyloid triggers neuron-derived inflammatory signaling in APP transgenic rats and human brain.
    Proc Natl Acad Sci U S A. 2020;117:6844-6854.
    >> Share

  55. WOO JA, Liu T, Fang CC, Castano MA, et al
    beta-Arrestin2 oligomers impair the clearance of pathological tau and increase tau aggregates.
    Proc Natl Acad Sci U S A. 2020;117:5006-5015.
    >> Share

  56. CHOI JH, Han J, Theodoropoulos PC, Zhong X, et al
    Essential requirement for nicastrin in marginal zone and B-1 B cell development.
    Proc Natl Acad Sci U S A. 2020;117:4894-4901.
    >> Share

    February 2020
  57. SEN T, Saha P, Jiang T, Sen N, et al
    Sulfhydration of AKT triggers Tau-phosphorylation by activating glycogen synthase kinase 3beta in Alzheimer's disease.
    Proc Natl Acad Sci U S A. 2020 Feb 12. pii: 1916895117.
    >> Share

  58. PENG J, Zhao T
    Reduction in TOM1 expression exacerbates Alzheimer's disease.
    Proc Natl Acad Sci U S A. 2020 Feb 11. pii: 1917589117.
    >> Share

  59. MARTINI AC, Baglietto-Vargas D, Medeiros R, LaFerla FM, et al
    Reply to Peng and Zhao: Loss of endocytic protein TOM1 in Alzheimer's disease.
    Proc Natl Acad Sci U S A. 2020 Feb 11. pii: 1917743117.
    >> Share

    December 2019
  60. HAQUE RU, Levey AI
    Alzheimer's disease: A clinical perspective and future nonhuman primate research opportunities.
    Proc Natl Acad Sci U S A. 2019 Dec 23. pii: 1912954116.
    >> Share

  61. ARNSTEN AFT, Datta D, Leslie S, Yang ST, et al
    Alzheimer's-like pathology in aging rhesus macaques: Unique opportunity to study the etiology and treatment of Alzheimer's disease.
    Proc Natl Acad Sci U S A. 2019 Dec 23. pii: 1903671116.
    >> Share


  62. Correction for Wang et al., Spatiotemporal activation of the C/EBPbeta/delta-secretase axis regulates the pathogenesis of Alzheimer's disease.
    Proc Natl Acad Sci U S A. 2019 Dec 9. pii: 1920626117.
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    November 2019
  63. AIKAWA T, Ren Y, Yamazaki Y, Tachibana M, et al
    ABCA7 haplodeficiency disturbs microglial immune responses in the mouse brain.
    Proc Natl Acad Sci U S A. 2019;116:23790-23796.
    >> Share

  64. PARK MH, Lee M, Nam G, Kim M, et al
    N,N'-Diacetyl-p-phenylenediamine restores microglial phagocytosis and improves cognitive defects in Alzheimer's disease transgenic mice.
    Proc Natl Acad Sci U S A. 2019 Nov 4. pii: 1916318116.
    >> Share

    October 2019
  65. CHEN ZL, Singh P, Wong J, Horn K, et al
    An antibody against HK blocks Alzheimer's disease peptide beta-amyloid-induced bradykinin release in human plasma.
    Proc Natl Acad Sci U S A. 2019 Oct 28. pii: 1914831116.
    >> Share

  66. SHARMA A, Kazim SF, Larson CS, Ramakrishnan A, et al
    Divergent roles of astrocytic versus neuronal EAAT2 deficiency on cognition and overlap with aging and Alzheimer's molecular signatures.
    Proc Natl Acad Sci U S A. 2019 Oct 7. pii: 1903566116.
    >> Share

    August 2019
  67. LOPEZ T, Mustafa Z, Chen C, Lee KB, et al
    Functional selection of protease inhibitory antibodies.
    Proc Natl Acad Sci U S A. 2019;116:16314-16319.
    >> Share

  68. DREGNI AJ, Mandala VS, Wu H, Elkins MR, et al
    In vitro 0N4R tau fibrils contain a monomorphic beta-sheet core enclosed by dynamically heterogeneous fuzzy coat segments.
    Proc Natl Acad Sci U S A. 2019;116:16357-16366.
    >> Share

    July 2019
  69. MICHAELS TCT, Weber CA, Mahadevan L
    Optimal control strategies for inhibition of protein aggregation.
    Proc Natl Acad Sci U S A. 2019;116:14593-14598.
    >> Share

    June 2019
  70. HU ZW, Vugmeyster L, Au DF, Ostrovsky D, et al
    Molecular structure of an N-terminal phosphorylated beta-amyloid fibril.
    Proc Natl Acad Sci U S A. 2019;116:11253-11258.
    >> Share


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