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Articles published in
Proc Natl Acad Sci U S A
    June 2025
  1. TIAN L, Long G, Zhu S, Wang Y, et al
    Nanoimmunomodulation of the Abeta-STING feedback machinery in microglia for Alzheimer's disease treatment.
    Proc Natl Acad Sci U S A. 2025;122:e2427257122.
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    May 2025

  2. Correction for Masliah et al., beta-Amyloid peptides enhance alpha-synuclein accumulation and neuronal deficits in a transgenic mouse model linking Alzheimer's disease and Parkinson's disease.
    Proc Natl Acad Sci U S A. 2025;122:e2509530122.
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  3. KOH Y, Vazquez-Rosa E, Gao F, Li H, et al
    Inhibiting 15-PGDH blocks blood-brain barrier deterioration and protects mice from Alzheimer's disease and traumatic brain injury.
    Proc Natl Acad Sci U S A. 2025;122:e2417224122.
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  4. CHEN W, Liu X, Munoz VR, Kahn CR, et al
    Loss of insulin signaling in microglia impairs cellular uptake of Abeta and neuroinflammatory response exacerbating AD-like neuropathology.
    Proc Natl Acad Sci U S A. 2025;122:e2501527122.
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    April 2025
  5. PAULSON AL, Zhang L, Prichard AM, Singer AC, et al
    40 Hz sensory stimulation enhances CA3-CA1 coordination and prospective coding during navigation in a mouse model of Alzheimer's disease.
    Proc Natl Acad Sci U S A. 2025;122:e2419364122.
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    March 2025
  6. YIN C, Imms P, Chowdhury NF, Chaudhari NN, et al
    Deep learning to quantify the pace of brain aging in relation to neurocognitive changes.
    Proc Natl Acad Sci U S A. 2025;122:e2413442122.
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  7. JOHNSON EA, Nowar R, Viola KL, Huang W, et al
    Inhibition of amyloid beta oligomer accumulation by NU-9: A unifying mechanism for the treatment of neurodegenerative diseases.
    Proc Natl Acad Sci U S A. 2025;122:e2402117122.
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  8. ZHANG X, Vlkolinsky R, Wu C, Dolatabadi N, et al
    S-Nitrosylation of CRTC1 in Alzheimer's disease impairs CREB-dependent gene expression induced by neuronal activity.
    Proc Natl Acad Sci U S A. 2025;122:e2418179122.
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    February 2025
  9. NGUYEN L, Ajredini R, Guo S, Romano LEL, et al
    CASP8 intronic expansion identified by poly-glycine-arginine pathology increases Alzheimer's disease risk.
    Proc Natl Acad Sci U S A. 2025;122:e2416885122.
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  10. YANG X, Wang Y, Qiao Y, Lin J, et al
    Astrocytic EphA4 signaling is important for the elimination of excitatory synapses in Alzheimer's disease.
    Proc Natl Acad Sci U S A. 2025;122:e2420324122.
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  11. JIANG WI, Cao Y, Xue Y, Ji Y, et al
    Suppressing APOE4-induced neural pathologies by targeting the VHL-HIF axis.
    Proc Natl Acad Sci U S A. 2025;122:e2417515122.
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    January 2025
  12. SNEIDERIENE G, Gonzalez Diaz A, Adhikari SD, Wei J, et al
    Lipid-induced condensate formation from the Alzheimer's Abeta peptide triggers amyloid aggregation.
    Proc Natl Acad Sci U S A. 2025;122:e2401307122.
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    December 2024
  13. CHAKRABORTY P, Ibanez de Opakua A, Purslow JA, Fromm SA, et al
    GSK3beta phosphorylation catalyzes the aggregation of tau into Alzheimer's disease-like filaments.
    Proc Natl Acad Sci U S A. 2024;121:e2414176121.
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  14. NATALE F, Spinelli M, Rinaudo M, Gulisano W, et al
    Inhibition of zDHHC7-driven protein S-palmitoylation prevents cognitive deficits in an experimental model of Alzheimer's disease.
    Proc Natl Acad Sci U S A. 2024;121:e2402604121.
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  15. KRISTENSEN M
    Insulin-inspired peptides may open new pathways to treat Alzheimer's disease.
    Proc Natl Acad Sci U S A. 2024;121:e2419741121.
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    October 2024
  16. KAMEI N, Ikeda K, Ohmoto Y, Fujisaki S, et al
    Insulin-inspired hippocampal neuron-targeting technology for protein drug delivery.
    Proc Natl Acad Sci U S A. 2024;121:e2407936121.
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    September 2024
  17. SATO K, Takayama KI, Saito Y, Inoue S, et al
    ERRalpha and ERRgamma coordinate expression of genes associated with Alzheimer's disease, inhibiting DKK1 to suppress tau phosphorylation.
    Proc Natl Acad Sci U S A. 2024;121:e2406854121.
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  18. ZHANG N, Zhang R, Jiang L, Gao Z, et al
    Inhibition of colorectal cancer in Alzheimer's disease is mediated by gut microbiota via induction of inflammatory tolerance.
    Proc Natl Acad Sci U S A. 2024;121:e2314337121.
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  19. JENSEN AMG, Raska J, Fojtik P, Monti G, et al
    The SORL1 p.Y1816C variant causes impaired endosomal dimerization and autosomal dominant Alzheimer's disease.
    Proc Natl Acad Sci U S A. 2024;121:e2408262121.
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    August 2024

  20. Retraction for Janczura et al., Inhibition of HDAC3 reverses Alzheimer's disease-related pathologies in vitro and in the 3xTg-AD mouse model.
    Proc Natl Acad Sci U S A. 2024;121:e2415279121.
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  21. YAN K, Zhang C, Kang J, Montenegro P, et al
    Cortical neurodegeneration caused by Psen1 mutations is independent of Abeta.
    Proc Natl Acad Sci U S A. 2024;121:e2409343121.
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  22. FRANK M, Ni P, Jensen M, Gerstein MB, et al
    Leveraging a large language model to predict protein phase transition: A physical, multiscale, and interpretable approach.
    Proc Natl Acad Sci U S A. 2024;121:e2320510121.
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  23. WEI X, Campagna JJ, Jagodzinska B, Wi D, et al
    A therapeutic small molecule enhances gamma-oscillations and improves cognition/memory in Alzheimer's disease model mice.
    Proc Natl Acad Sci U S A. 2024;121:e2400420121.
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  24. PLASCENCIA-VILLA G, Castellani RJ, Perry G
    Central role of brain regulatory T cells in the inflammatory cascade in Alzheimer's disease.
    Proc Natl Acad Sci U S A. 2024;121:e2412255121.
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    July 2024
  25. PANWAR A, Rentsendorj A, Jhun M, Cohen RM, et al
    Antigen-specific age-related memory CD8 T cells induce and track Alzheimer's-like neurodegeneration.
    Proc Natl Acad Sci U S A. 2024;121:e2401420121.
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  26. MALAQUIN S, Lerchundi R, Mougel E, Valette J, et al
    Capturing alterations of intracellular-extracellular lactate distribution in the brain using diffusion-weighted MR spectroscopy in vivo.
    Proc Natl Acad Sci U S A. 2024;121:e2403635121.
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    June 2024
  27. AXELL E, Hu J, Lindberg M, Dear AJ, et al
    The role of shear forces in primary and secondary nucleation of amyloid fibrils.
    Proc Natl Acad Sci U S A. 2024;121:e2322572121.
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    May 2024
  28. TURNER GR, Hewan P, Wearn A, van Dooren R, et al
    Locus coeruleus integrity is related to an exploitation-based decision-making bias in older adulthood.
    Proc Natl Acad Sci U S A. 2024;121:e2322617121.
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    April 2024
  29. SINGH PK, Simoes-Pires EN, Chen ZL, Torrente D, et al
    Lecanemab blocks the effects of the Abeta/fibrinogen complex on blood clots and synapse toxicity in organotypic culture.
    Proc Natl Acad Sci U S A. 2024;121:e2314450121.
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    March 2024
  30. MAMMERI NE, Dregni AJ, Duan P, Hong M, et al
    Structures of AT8 and PHF1 phosphomimetic tau: Insights into the posttranslational modification code of tau aggregation.
    Proc Natl Acad Sci U S A. 2024;121:e2316175121.
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    December 2023
  31. ZHANG H, Chen Y, Yu M, Xi Y, et al
    Nasal delivery of polymeric nanoDisc mobilizes a synergy of central and peripheral amyloid-beta clearance to treat Alzheimer's disease.
    Proc Natl Acad Sci U S A. 2023;120:e2304213120.
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  32. WANG W, Ma X, Bhatta S, Shao C, et al
    Intraneuronal beta-amyloid impaired mitochondrial proteostasis through the impact on LONP1.
    Proc Natl Acad Sci U S A. 2023;120:e2316823120.
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  33. ZHANG J, Wickizer C, Ding W, Van R, et al
    In vivo three-dimensional brain imaging with chemiluminescence probes in Alzheimer's disease models.
    Proc Natl Acad Sci U S A. 2023;120:e2310131120.
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    November 2023
  34. BODILY TA, Ramanathan A, Wei S, Karkisaval A, et al
    In pursuit of degenerative brain disease diagnosis: Dementia biomarkers detected by DNA aptamer-attached portable graphene biosensor.
    Proc Natl Acad Sci U S A. 2023;120:e2311565120.
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  35. NIERE F, Uneri A, McArdle CJ, Deng Z, et al
    Aberrant DJ-1 expression underlies L-type calcium channel hypoactivity in dendrites in tuberous sclerosis complex and Alzheimer's disease.
    Proc Natl Acad Sci U S A. 2023;120:e2301534120.
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    October 2023
  36. DUAN P, Dregni AJ, Mammeri NE, Hong M, et al
    Structure of the nonhelical filament of the Alzheimer's disease tau core.
    Proc Natl Acad Sci U S A. 2023;120:e2310067120.
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  37. MONTENEGRO P, Chen P, Kang J, Lee SH, et al
    Human Presenilin-1 delivered by AAV9 rescues impaired gamma-secretase activity, memory deficits, and neurodegeneration in Psen mutant mice.
    Proc Natl Acad Sci U S A. 2023;120:e2306714120.
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  38. ABSKHARON R, Pan H, Sawaya MR, Seidler PM, et al
    Structure-based design of nanobodies that inhibit seeding of Alzheimer's patient-extracted tau fibrils.
    Proc Natl Acad Sci U S A. 2023;120:e2300258120.
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  39. LU K, Li C, Liu J, Wang J, et al
    Impairments in endogenous AMPA receptor dynamics correlates with learning deficits in Alzheimer's disease model mice.
    Proc Natl Acad Sci U S A. 2023;120:e2303878120.
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  40. LIM CM, Gonzalez Diaz A, Fuxreiter M, Pun FW, et al
    Multiomic prediction of therapeutic targets for human diseases associated with protein phase separation.
    Proc Natl Acad Sci U S A. 2023;120:e2300215120.
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    September 2023
  41. LOPES JR, Zhang X, Mayrink J, Tatematsu BK, et al
    Nasal administration of anti-CD3 monoclonal antibody ameliorates disease in a mouse model of Alzheimer's disease.
    Proc Natl Acad Sci U S A. 2023;120:e2309221120.
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  42. LE GUEN Y, Luo G, Ambati A, Damotte V, et al
    Multiancestry analysis of the HLA locus in Alzheimer's and Parkinson's diseases uncovers a shared adaptive immune response mediated by HLA-DRB1*04 subtypes.
    Proc Natl Acad Sci U S A. 2023;120:e2302720120.
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  43. CHEN ZL, Singh PK, Calvano M, Norris EH, et al
    A possible mechanism for the enhanced toxicity of beta-amyloid protofibrils in Alzheimer's disease.
    Proc Natl Acad Sci U S A. 2023;120:e2309389120.
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    August 2023
  44. SOULA M, Maslarova A, Harvey RE, Valero M, et al
    Interictal epileptiform discharges affect memory in an Alzheimer's disease mouse model.
    Proc Natl Acad Sci U S A. 2023;120:e2302676120.
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  45. NAKANO-KOBAYASHI A, Canela A, Yoshihara T, Hagiwara M, et al
    Astrocyte-targeting therapy rescues cognitive impairment caused by neuroinflammation via the Nrf2 pathway.
    Proc Natl Acad Sci U S A. 2023;120:e2303809120.
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    July 2023
  46. CAZZARO S, Woo JA, Wang X, Liu T, et al
    Slingshot homolog-1-mediated Nrf2 sequestration tips the balance from neuroprotection to neurodegeneration in Alzheimer's disease.
    Proc Natl Acad Sci U S A. 2023;120:e2217128120.
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    June 2023
  47. THACKER D, Barghouth M, Bless M, Zhang E, et al
    Direct observation of secondary nucleation along the fibril surface of the amyloid beta 42 peptide.
    Proc Natl Acad Sci U S A. 2023;120:e2220664120.
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  48. ENNERFELT H, Holliday C, Shapiro DA, Zengeler KE, et al
    CARD9 attenuates Abeta pathology and modifies microglial responses in an Alzheimer's disease mouse model.
    Proc Natl Acad Sci U S A. 2023;120:e2303760120.
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    May 2023
  49. KREUTZER AG, Guaglianone G, Yoo S, Parrocha CMT, et al
    Probing differences among Abeta oligomers with two triangular trimers derived from Abeta.
    Proc Natl Acad Sci U S A. 2023;120:e2219216120.
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  50. ZHOU GF, Tang J, Ma YL, Fu X, et al
    ARL6IP1 mediates small-molecule-induced alleviation of Alzheimer pathology through FXR1-dependent BACE1 translation initiation.
    Proc Natl Acad Sci U S A. 2023;120:e2220148120.
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  51. GHOSH S, Tugarinov V, Clore GM
    Quantitative NMR analysis of the mechanism and kinetics of chaperone Hsp104 action on amyloid-beta42 aggregation and fibril formation.
    Proc Natl Acad Sci U S A. 2023;120:e2305823120.
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  52. MILLER A, Wei J, Meehan S, Dobson CM, et al
    Formation of amyloid loops in brain tissues is controlled by the flexibility of protofibril chains.
    Proc Natl Acad Sci U S A. 2023;120:e2216234120.
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  53. CHEN W, Huang Q, Lazdon EK, Gomes A, et al
    Loss of insulin signaling in astrocytes exacerbates Alzheimer-like phenotypes in a 5xFAD mouse model.
    Proc Natl Acad Sci U S A. 2023;120:e2220684120.
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  54. YANG XK, Zhang FL, Jin XK, Jiao YT, et al
    Nanoelectrochemistry reveals how soluble Abeta(42) oligomers alter vesicular storage and release of glutamate.
    Proc Natl Acad Sci U S A. 2023;120:e2219994120.
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  55. HASSANI SA, Neumann A, Russell J, Jones CK, et al
    M(1)-selective muscarinic allosteric modulation enhances cognitive flexibility and effective salience in nonhuman primates.
    Proc Natl Acad Sci U S A. 2023;120:e2216792120.
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    March 2023
  56. CONDELLO C, Ayers JI, Dalgard CL, Garcia Garcia MM, et al
    Guam ALS-PDC is a distinct double-prion disorder featuring both tau and Abeta prions.
    Proc Natl Acad Sci U S A. 2023;120:e2220984120.
    >> Share

  57. YANG H, Yuan P, Wu Y, Shi M, et al
    EMBER multidimensional spectral microscopy enables quantitative determination of disease- and cell-specific amyloid strains.
    Proc Natl Acad Sci U S A. 2023;120:e2300769120.
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  58. LEE M, Yau WM, Louis JM, Tycko R, et al
    Structures of brain-derived 42-residue amyloid-beta fibril polymorphs with unusual molecular conformations and intermolecular interactions.
    Proc Natl Acad Sci U S A. 2023;120:e2218831120.
    >> Share


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