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Alzheimer's Disease

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Articles published in
    June 2024
  1. COOMANS EM, Ossenkoppele R
    The implications of amyloid-beta pathology: only time will tell.
    Brain. 2024;147:1934-1936.
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    May 2024
  2. ALTMANN A, Aksman LM, Oxtoby NP, Young A, et al
    Towards cascading genetic risk in Alzheimer's disease.
    Brain. 2024 May 31:awae176. doi: 10.1093.
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  3. CHEN F, Zhao J, Meng F, He F, et al
    The vascular contribution of apolipoprotein E to Alzheimer's disease.
    Brain. 2024 May 15:awae156. doi: 10.1093.
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  4. SOCH J, Richter A, Kizilirmak JM, Schutze H, et al
    Single-value brain activity scores reflect both severity and risk across the Alzheimer's continuum.
    Brain. 2024 May 14:awae149. doi: 10.1093.
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  5. BLUM D, Levi S
    Targeting excitatory:inhibitory network imbalance in Alzheimer's disease.
    Brain. 2024 May 13:awae146. doi: 10.1093.
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  6. SANCHEZ-JUAN P, Valeriano-Lorenzo E, Ruiz-Gonzalez A, Pastor AB, et al
    Serum GFAP levels correlate with astrocyte reactivity, post-mortem brain atrophy and neurofibrillary tangles.
    Brain. 2024;147:1667-1679.
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  7. DING F, Sun Q, Long C, Rasmussen RN, et al
    Dysregulation of extracellular potassium distinguishes healthy ageing from neurodegeneration.
    Brain. 2024;147:1726-1739.
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    April 2024
  8. CODY KA, Langhough RE, Zammit MD, Clark L, et al
    Characterizing brain tau and cognitive decline along the amyloid timeline in Alzheimer's disease.
    Brain. 2024 Apr 26:awae116. doi: 10.1093.
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  9. BARBOUR AJ, Gourmaud S, Lancaster E, Li X, et al
    Seizures exacerbate excitatory: inhibitory imbalance in Alzheimer's disease and 5XFAD mice.
    Brain. 2024 Apr 25:awae126. doi: 10.1093.
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  10. LIMBERGER C, Zimmer ER
    Blood GFAP reflects astrocyte reactivity to Alzheimer's pathology in post-mortem brain tissue.
    Brain. 2024 Apr 18:awae104. doi: 10.1093.
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  11. Correction to: Disrupted daily activity/rest cycles in relation to daily cortisol rhythms of home-dwelling patients with early Alzheimer's dementia.
    Brain. 2024 Apr 10:awae103. doi: 10.1093.
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  12. WANG YT, Therriault J, Servaes S, Tissot C, et al
    Sex-specific modulation of amyloid-beta on tau phosphorylation underlies faster tangle accumulation in females.
    Brain. 2024;147:1497-1510.
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  13. TANAKA H, Martinez-Valbuena I, Forrest SL, Couto B, et al
    Distinct involvement of the cranial and spinal nerves in progressive supranuclear palsy.
    Brain. 2024;147:1399-1411.
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  14. CORRIVEAU-LECAVALIER N, Barnard LR, Botha H, Graff-Radford J, et al
    Uncovering the distinct macro-scale anatomy of dysexecutive and behavioural degenerative diseases.
    Brain. 2024;147:1483-1496.
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    March 2024
  15. HUNG C, Fertan E, Livesey FJ, Klenerman D, et al
    APP antisense oligonucleotides reduce Abeta aggregation and rescue endolysosomal dysfunction in Alzheimer's disease.
    Brain. 2024 Mar 25:awae092. doi: 10.1093.
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  16. RODRIGUEZ-RODRIGUEZ P, Arroyo-Garcia LE, Tsagkogianni C, Li L, et al
    A cell autonomous regulator of neuronal excitability modulates tau in Alzheimer's disease vulnerable neurons.
    Brain. 2024 Mar 11:awae051. doi: 10.1093.
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  17. RODRIGUEZ-VIEITEZ E, Vannini P, Montal V, Graff C, et al
    Cortical microstructural imaging from diffusion MRI: towards sensitive biomarkers for clinical trials.
    Brain. 2024;147:746-748.
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  18. DE MEYER S, Blujdea ER, Schaeverbeke J, Reinartz M, et al
    Longitudinal associations of serum biomarkers with early cognitive, amyloid and grey matter changes.
    Brain. 2024;147:936-948.
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    February 2024
  19. YANG HS, Yau WW, Carlyle BC, Trombetta BA, et al
    Plasma VEGFA and PGF impact longitudinal tau and cognition in preclinical Alzheimer's disease.
    Brain. 2024 Feb 5:awae034. doi: 10.1093.
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  20. AHMED H, Wang Y, Griffiths WJ, Levey AI, et al
    Brain cholesterol and Alzheimer's disease: challenges and opportunities in probe and drug development.
    Brain. 2024 Feb 1:awae028. doi: 10.1093.
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  21. ALBERT-GASCO H, Smith HL, Alvarez-Castelao B, Swinden D, et al
    Trazodone rescues dysregulated synaptic and mitochondrial nascent proteomes in prion neurodegeneration.
    Brain. 2024;147:649-664.
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    January 2024
  22. KUMAR M, Quittot N, Dujardin S, Schlaffner CN, et al
    Alzheimer proteopathic tau seeds are biochemically a forme fruste of mature paired helical filaments.
    Brain. 2024 Jan 18:awad378. doi: 10.1093.
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  23. KIIANITSA K, Lukes ME, Hayes BJ, Brutman J, et al
    TREM2 variants that cause early dementia and increase Alzheimer's disease risk affect gene splicing.
    Brain. 2024 Jan 16:awae014. doi: 10.1093.
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  24. HAN Y, Chen K, Zhang B, Yu H, et al
    Maf1 loss regulates spinogenesis and attenuates cognitive impairment in Alzheimer's disease.
    Brain. 2024 Jan 16:awae015. doi: 10.1093.
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  25. QIN C, Chen M, Dong MH, Yang S, et al
    Soluble TREM2 triggers microglial dysfunction in neuromyelitis optica spectrum disorders.
    Brain. 2024;147:163-176.
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    December 2023
  26. SAMANTA S, Akhter F, Roy A, Chen D, et al
    New cyclophilin D inhibitor rescues mitochondrial and cognitive function in Alzheimer's disease.
    Brain. 2023 Dec 26:awad432. doi: 10.1093.
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  27. SPOTORNO N, Strandberg O, Stomrud E, Janelidze S, et al
    Diffusion MRI tracks cortical microstructural changes during the early stages of Alzheimer's disease.
    Brain. 2023 Dec 21:awad428. doi: 10.1093.
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  28. STOUFFER KM, Grande X, Duezel E, Johansson M, et al
    Amidst an amygdala renaissance in Alzheimer's disease.
    Brain. 2023 Dec 18:awad411. doi: 10.1093.
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  29. YUYAMA K, Sun H, Fujii R, Hemmi I, et al
    Extracellular vesicle proteome unveils cathepsin B connection to Alzheimer's disease pathogenesis.
    Brain. 2023 Dec 10:awad361. doi: 10.1093.
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  30. TARUTANI A, Kametani F, Tahira M, Saito Y, et al
    Distinct tau folds initiate templated seeding and alter the post-translational modification profile.
    Brain. 2023;146:4988-4999.
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  31. GUBERT C, Hannan AJ
    Microbial manipulation of memories and minds.
    Brain. 2023;146:4791-4793.
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    November 2023
  32. QUESNEL MJ, Labonte A, Picard C, Zetterberg H, et al
    Insulin-like growth factor binding protein-2 in at-risk adults and autopsy-confirmed Alzheimer brains.
    Brain. 2023 Nov 22:awad398. doi: 10.1093.
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  33. SILVA-RODRIGUEZ J, Labrador-Espinosa MA, Moscoso A, Scholl M, et al
    Characteristics of amnestic patients with hypometabolism patterns suggestive of Lewy body pathology.
    Brain. 2023;146:4520-4531.
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  34. HAMPEL H, Elhage A, Cho M, Apostolova LG, et al
    Amyloid-related imaging abnormalities (ARIA): radiological, biological and clinical characteristics.
    Brain. 2023;146:4414-4424.
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  35. RAMANAN VK, Gebre RK, Graff-Radford J, Hofrenning E, et al
    Genetic risk scores enhance the diagnostic value of plasma biomarkers of brain amyloidosis.
    Brain. 2023;146:4508-4519.
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    October 2023
  36. GRABRUCKER S, Marizzoni M, Silajdzic E, Lopizzo N, et al
    Microbiota from Alzheimer's patients induce deficits in cognition and hippocampal neurogenesis.
    Brain. 2023 Oct 18:awad303. doi: 10.1093.
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  37. TUNOLD JA, Tan MMX, Koga S, Geut H, et al
    Lysosomal polygenic risk is associated with the severity of neuropathology in Lewy body disease.
    Brain. 2023;146:4077-4087.
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  38. KEPP KP, Robakis NK, Hoilund-Carlsen PF, Sensi SL, et al
    The amyloid cascade hypothesis: an updated critical review.
    Brain. 2023;146:3969-3990.
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  39. DU F, Yu Q, Swerdlow RH, Waites CL, et al
    Glucocorticoid-driven mitochondrial damage stimulates Tau pathology.
    Brain. 2023;146:4378-4394.
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    September 2023
  40. COOMANS EM, van Westen D, Pichet Binette A, Strandberg O, et al
    Interactions between vascular burden and amyloid-beta pathology on trajectories of tau accumulation.
    Brain. 2023 Sep 18:awad317. doi: 10.1093.
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  41. HARDY J, Mummery C
    Reply: Lecanemab: turning point, or status quo? An ethics perspective.
    Brain. 2023;146:e73.
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  42. BOCANCEA DI, Svenningsson AL, van Loenhoud AC, Groot C, et al
    Determinants of cognitive and brain resilience to tau pathology: a longitudinal analysis.
    Brain. 2023;146:3719-3734.
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  43. DALY T
    Lecanemab: turning point, or status quo? An ethics perspective.
    Brain. 2023;146:e71-e72.
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  44. COOMANS EM, Tomassen J, Ossenkoppele R, Tijms BM, et al
    Genetically identical twin-pair difference models support the amyloid cascade hypothesis.
    Brain. 2023;146:3735-3746.
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    August 2023
  45. KERAMIDIS I, McAllister BB, Bourbonnais J, Wang F, et al
    Restoring neuronal chloride extrusion reverses cognitive decline linked to Alzheimer's disease mutations.
    Brain. 2023 Aug 8:awad250. doi: 10.1093.
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  46. JUNG Y, Damoiseaux JS
    The potential of blood neurofilament light as a marker of neurodegeneration for Alzheimer's disease.
    Brain. 2023 Aug 4:awad267. doi: 10.1093.
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  47. WUESTEFELD A, Pichet Binette A, Berron D, Spotorno N, et al
    Age-related and amyloid-beta-independent tau deposition and its downstream effects.
    Brain. 2023;146:3192-3205.
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  48. RAHAYEL S, Tremblay C, Vo A, Misic B, et al
    Mitochondrial function-associated genes underlie cortical atrophy in prodromal synucleinopathies.
    Brain. 2023;146:3301-3318.
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  49. MCMILLAN PJ, Benbow SJ, Uhrich R, Saxton A, et al
    Tau-RNA complexes inhibit microtubule polymerization and drive disease-relevant conformation change.
    Brain. 2023;146:3206-3220.
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    July 2023
  50. GARCIA AM, de Leon J, Tee BL, Blasi DE, et al
    Speech and language markers of neurodegeneration: a call for global equity.
    Brain. 2023 Jul 27:awad253. doi: 10.1093.
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  51. AKSMAN LM, Oxtoby NP, Scelsi MA, Wijeratne PA, et al
    A data-driven study of Alzheimer's disease related amyloid and tau pathology progression.
    Brain. 2023 Jul 11:awad232. doi: 10.1093.
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  52. YOUNG AL, Vogel JW, Robinson JL, McMillan CT, et al
    Data-driven neuropathological staging and subtyping of TDP-43 proteinopathies.
    Brain. 2023;146:2975-2988.
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    June 2023

  53. Correction to: Brain-derived tau: a novel blood-based biomarker for Alzheimer's disease-type neurodegeneration.
    Brain. 2023 Jun 27:awad208. doi: 10.1093.
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  54. VAN DER ENDE EL, In 't Veld SGJG, Hanskamp I, van der Lee S, et al
    CSF proteomics in autosomal dominant Alzheimer's disease highlights parallels with sporadic disease.
    Brain. 2023 Jun 22:awad213. doi: 10.1093.
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  55. BANERJEE G, Collinge J, Fox NC, Lashley T, et al
    Clinical considerations in early-onset cerebral amyloid angiopathy.
    Brain. 2023 Jun 6:awad193. doi: 10.1093.
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  56. SCHOONHOVEN DN, Coomans EM, Millan AP, van Nifterick AM, et al
    Tau protein spreads through functionally connected neurons in Alzheimer's disease: a combined MEG/PET study.
    Brain. 2023 Jun 5:awad189. doi: 10.1093.
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  57. Correction: The most valuable player or the tombstone: is tau the correct target to treat Alzheimer's disease?
    Brain. 2023 Jun 1:awad176. doi: 10.1093.
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  58. EDWARDS HM, Wallace CE, Gardiner WD, Doherty BM, et al
    Sex-dependent effects of acute stress on amyloid-beta in male and female mice.
    Brain. 2023;146:2268-2274.
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  59. ROBINSON JL, Xie SX, Baer DR, Suh E, et al
    Pathological combinations in neurodegenerative disease are heterogeneous and disease-associated.
    Brain. 2023;146:2557-2569.
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    May 2023
  60. ZHU M, Xiao B, Xue T, Qin S, et al
    Cdc42GAP deficiency contributes to the Alzheimer's disease phenotype.
    Brain. 2023 May 31:awad184. doi: 10.1093.
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  61. DAS V, Hajduch M
    Randomizing for Alzheimer's disease drug trials should consider the cancer history of participants.
    Brain. 2023 May 27:awad177. doi: 10.1093.
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  62. HARDY J, Mummery C
    Reply: Unblinding in the lecanemab trial in Alzheimer's disease.
    Brain. 2023 May 23:awad201. doi: 10.1093.
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    Unblinding in the lecanemab trial in Alzheimer's disease.
    Brain. 2023 May 18:awad171. doi: 10.1093.
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  64. KORETSKY MJ, Alvarado C, Makarious MB, Vitale D, et al
    Genetic risk factor clustering within and across neurodegenerative diseases.
    Brain. 2023 May 16:awad161. doi: 10.1093.
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  65. JIANG J, Johnson JCS, Requena-Komuro MC, Benhamou E, et al
    Comprehension of acoustically degraded speech in Alzheimer's disease and primary progressive aphasia.
    Brain. 2023 May 15:awad163. doi: 10.1093.
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  66. YOUNES K, Sha SJ
    The MVP or the tombstone: is tau the correct target to treat Alzheimer's disease?
    Brain. 2023 May 8:awad151. doi: 10.1093.
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    April 2023
  67. GOSSYE H, Van Mossevelde S, Sieben A, Bjerke M, et al
    Patients carrying the mutation p.R406W in MAPT present with non-conforming phenotypic spectrum.
    Brain. 2023;146:1624-1636.
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  68. PONNUSAMY M, Wang S, Yuksel M, Hansen MT, et al
    Loss of forebrain BIN1 attenuates hippocampal pathology and neuroinflammation in a tauopathy model.
    Brain. 2023;146:1561-1579.
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  69. NAM MH, Ko HY, Kim D, Lee S, et al
    Visualizing reactive astrocyte-neuron interaction in Alzheimer's disease using 11C-acetate and 18F-FDG.
    Brain. 2023 Apr 17:awad037. doi: 10.1093.
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  70. MATTSSON-CARLGREN N, Palmqvist S
    The emerging era of staging Alzheimer's disease pathology using plasma biomarkers.
    Brain. 2023 Apr 6:awad112. doi: 10.1093.
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    March 2023

  71. Correction to: Blood-brain barrier opening of the default mode network in Alzheimer's disease with magnetic resonance-guided focused ultrasound.
    Brain. 2023 Mar 22:awad082. doi: 10.1093.
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  72. DONADIO V, Incensi A, Rizzo G, Westermark GT, et al
    Phosphorylated alpha-synuclein in skin Schwann cells: a new biomarker for multiple system atrophy.
    Brain. 2023;146:1065-1074.
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  73. GREVE HJ, Dunbar AL, Lombo CG, Ahmed C, et al
    The bidirectional lung brain-axis of amyloid-beta pathology: ozone dysregulates the peri-plaque microenvironment.
    Brain. 2023;146:991-1005.
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    February 2023
  74. HARDY J, Mummery C
    An anti-amyloid therapy works for Alzheimer's disease: why has it taken so long and what is next?
    Brain. 2023 Feb 17:awad049. doi: 10.1093.
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  75. JACK CR, Wiste HJ, Algeciras-Schimnich A, Figdore DJ, et al
    Predicting amyloid PET and tau PET stages with plasma biomarkers.
    Brain. 2023 Feb 15:awad042. doi: 10.1093.
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  76. HUSAIN M
    Screening for Alzheimer's disease: plasma biomarkers and what else?
    Brain. 2023;146:407-408.
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  77. FLORIAN H, Wang D, Arnold SE, Boada M, et al
    Tilavonemab in early Alzheimer's disease: results from a phase 2, randomized, double-blind study.
    Brain. 2023 Feb 2:awad024. doi: 10.1093.
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  78. KOCH G, Martorana A
    Reply: Can transcranial magnetic stimulation rescue dopaminergic signalling in Alzheimer disease?
    Brain. 2023 Feb 2:awad020. doi: 10.1093.
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  79. D'AMELIO M, Di Lazzaro V
    Can transcranial magnetic stimulation rescue dopaminergic signalling in Alzheimer disease?
    Brain. 2023 Feb 2:awad019. doi: 10.1093.
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    January 2023
  80. MARUSZAK A, Silajdzic E, Lee H, Murphy T, et al
    Predicting progression to Alzheimer's disease with human hippocampal progenitors exposed to serum.
    Brain. 2023 Jan 27:awac472. doi: 10.1093.
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  81. MENG Y, Goubran M, Rabin JS, McSweeney M, et al
    Blood-brain barrier opening of the default mode network in Alzheimer's disease with magnetic resonance-guided focused ultrasound.
    Brain. 2023 Jan 25:awac459. doi: 10.1093.
    >> Share

  82. PERNECZKY R, Jessen F, Grimmer T, Levin J, et al
    Anti-amyloid antibody therapies in Alzheimer's disease.
    Brain. 2023 Jan 19:awad005. doi: 10.1093.
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  83. JOHANSSON C, Thordardottir S, Laffita-Mesa J, Rodriguez-Vieitez E, et al
    Plasma biomarker profiles in autosomal dominant Alzheimer's disease.
    Brain. 2023 Jan 11:awac399. doi: 10.1093.
    >> Share

  84. WHEELOCK MD, Strain JF, Mansfield P, Tu JC, et al
    Brain network decoupling with increased serum neurofilament and reduced cognitive function in Alzheimer's disease.
    Brain. 2023 Jan 10:awac498. doi: 10.1093.
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  85. VAN ARENDONK J, Neitzel J, Steketee RME, van Assema DME, et al
    Diabetes and hypertension are related to amyloid-beta burden in the population-based Rotterdam Study.
    Brain. 2023;146:337-348.
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  86. KATSUMI Y, Putcha D, Eckbo R, Wong B, et al
    Anterior dorsal attention network tau drives visual attention deficits in posterior cortical atrophy.
    Brain. 2023;146:295-306.
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  87. BLOMMER J, Pitcher T, Mustapic M, Eren E, et al
    Extracellular vesicle biomarkers for cognitive impairment in Parkinson's disease.
    Brain. 2023;146:195-208.
    >> Share

    December 2022
  88. GONZALEZ-ORTIZ F, Turton M, Kac PR, Smirnov D, et al
    Brain-derived tau: a novel blood-based biomarker for Alzheimer's disease-type neurodegeneration.
    Brain. 2022 Dec 27:awac407. doi: 10.1093.
    >> Share

  89. KOOP EA, Jacobs HIL
    Untangling white matter fibre changes in Alzheimer's disease and small vessel disease.
    Brain. 2022 Dec 26:awac493. doi: 10.1093.
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  90. WISCH JK, Butt OH, Gordon BA, Schindler SE, et al
    Proteomic clusters underlie heterogeneity in preclinical Alzheimer's disease progression.
    Brain. 2022 Dec 21:awac484. doi: 10.1093.
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  91. PERANI D
    The impact of integrated brain molecular PET measures on DLB cognitive phenotype and clinical course.
    Brain. 2022;145:4157-4159.
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    November 2022
    Repetitive TMS applied to the precuneus stabilizes cognitive status in Alzheimer's disease.
    Brain. 2022;145:3730-3732.
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  93. OBERSTEIN TJ, Schmidt MA, Florvaag A, Haas AL, et al
    Amyloid-beta levels and cognitive trajectories in non-demented pTau181-positive subjects without amyloidopathy.
    Brain. 2022;145:4032-4041.
    >> Share

  94. BETTHAUSER TJ, Bilgel M, Koscik RL, Jedynak BM, et al
    Multi-method investigation of factors influencing amyloid onset and impairment in three cohorts.
    Brain. 2022;145:4065-4079.
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  95. HUGHES TM, Craft S
    Cerebral insulin receptors: a nexus for vascular and metabolic contributions to Alzheimer's disease.
    Brain. 2022 Nov 19:awac433. doi: 10.1093.
    >> Share

    October 2022
  96. SEYEDSALEHI A, Warrier V, Bethlehem RAI, Perry BI, et al
    Educational attainment, structural brain reserve and Alzheimer's disease: a Mendelian randomization analysis.
    Brain. 2022 Oct 31. pii: 6780317. doi: 10.1093.
    >> Share

  97. NEMY M, Dyrba M, Brosseron F, Buerger K, et al
    Cholinergic white matter pathways along the Alzheimer's disease continuum.
    Brain. 2022 Oct 26. pii: 6775152. doi: 10.1093.
    >> Share

  98. KOCH G, Casula EP, Bonni S, Borghi I, et al
    Precuneus magnetic stimulation for Alzheimer's disease: a randomized, sham-controlled trial.
    Brain. 2022 Oct 25. pii: 6701823. doi: 10.1093.
    >> Share

  99. LECLERC M, Bourassa P, Tremblay C, Caron V, et al
    Cerebrovascular insulin receptors are defective in Alzheimer's disease.
    Brain. 2022 Oct 25. pii: 6761474. doi: 10.1093.
    >> Share

  100. LI X, Ospitalieri S, Robberechts T, Hofmann L, et al
    Seeding, maturation and propagation of amyloid beta-peptide aggregates in Alzheimer's disease.
    Brain. 2022;145:3558-3570.
    >> Share

  101. SINGLETON EH, Fieldhouse JLP, van 't Hooft JJ, Scarioni M, et al
    Social cognition deficits and biometric signatures in the behavioural variant of Alzheimer's disease.
    Brain. 2022 Oct 21. pii: 6765142. doi: 10.1093.
    >> Share

    September 2022
  102. SPOTORNO N, Strandberg O, Vis G, Stomrud E, et al
    Measures of cortical microstructure are linked to amyloid pathology in Alzheimer's disease.
    Brain. 2022 Sep 21. pii: 6710203. doi: 10.1093.
    >> Share

  103. JANELIDZE S, Bali D, Ashton NJ, Barthelemy NR, et al
    Head-to-head comparison of 10 plasma phospho-tau assays in prodromal Alzheimer's disease.
    Brain. 2022 Sep 10. pii: 6695388. doi: 10.1093.
    >> Share

  104. GROOT C, Smith R, Stomrud E, Binette AP, et al
    Phospho-tau with subthreshold tau-PET predicts increased tau accumulation rates in amyloid-positive individuals.
    Brain. 2022 Sep 9. pii: 6695020. doi: 10.1093.
    >> Share

  105. BUCKLEY R
    Sex differences in Alzheimer's disease risk: are immune responses the key?
    Brain. 2022 Sep 2. pii: 6686583. doi: 10.1093.
    >> Share

    August 2022
  106. RABIN JS, Nichols E, La Joie R, Casaletto KB, et al
    Cerebral amyloid angiopathy interacts with neuritic amyloid plaques to promote tau and cognitive decline.
    Brain. 2022;145:2823-2833.
    >> Share

  107. SNELLMAN A, Lantero-Rodriguez J, Emersic A, Vrillon A, et al
    N-terminal and mid-region tau fragments as fluid biomarkers in neurological diseases.
    Brain. 2022;145:2834-2848.
    >> Share

  108. RIKU Y, Iwasaki Y, Ishigaki S, Akagi A, et al
    Motor neuron TDP-43 proteinopathy in progressive supranuclear palsy and corticobasal degeneration.
    Brain. 2022;145:2769-2784.
    >> Share

  109. SAPKOTA D, Florian C, Doherty BM, White KM, et al
    Aqp4 stop codon readthrough facilitates amyloid-beta clearance from the brain.
    Brain. 2022 Aug 24. pii: 6671408. doi: 10.1093.
    >> Share

  110. INSEL PS, Young CB, Aisen PS, Johnson KA, et al
    Tau positron emission tomography in preclinical Alzheimer's disease.
    Brain. 2022 Aug 13. pii: 6665667. doi: 10.1093.
    >> Share

  111. COURSE MM, Gudsnuk K, Keene CD, Bird TD, et al
    Aberrant splicing of PSEN2, but not PSEN1, in individuals with sporadic Alzheimer's disease.
    Brain. 2022 Aug 11. pii: 6660735. doi: 10.1093.
    >> Share

  112. LUO J, Agboola F, Grant E, Morris JC, et al
    Accelerated longitudinal changes and ordering of Alzheimer disease biomarkers across the adult lifespan.
    Brain. 2022 Aug 4. pii: 6655799. doi: 10.1093.
    >> Share

    July 2022
  113. HUSAIN M
    Molecular pathology and biomarker of progression in Alzheimer's disease.
    Brain. 2022;145:2229-2230.
    >> Share

  114. GROOT C, Holstege H, Ossenkoppele R
    Do genetic factors contribute to sex-specific differences in resilience to amyloid pathology?
    Brain. 2022;145:2239-2241.
    >> Share

  115. CASALETTO KB, Nichols E, Aslanyan V, Simone SM, et al
    Sex-specific effects of microglial activation on Alzheimer's disease proteinopathy in older adults.
    Brain. 2022 Jul 23. pii: 6648895. doi: 10.1093.
    >> Share

  116. LONG JM, Coble DW, Xiong C, Schindler SE, et al
    Preclinical Alzheimer's disease biomarkers accurately predict cognitive and neuropathological outcomes.
    Brain. 2022 Jul 22. pii: 6648721. doi: 10.1093.
    >> Share

  117. DEWENTER A, Jacob MA, Cai M, Gesierich B, et al
    Disentangling the effects of Alzheimer's and small vessel disease on white matter fibre tracts.
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    Alzheimer's disease, cerebrovascular disease and dementia: lump, split or integrate?
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    Activation of Wnt/beta-catenin pathway mitigates blood-brain barrier dysfunction in Alzheimer's disease.
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    June 2022
    Progress towards predicting neurodegeneration and dementia after traumatic brain injury.
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  121. JENKINS LM, Wang L, Rosen H, Weintraub S, et al
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  122. MEHRARAM R, Peraza LR, Murphy NRE, Cromarty RA, et al
    Functional and structural brain network correlates of visual hallucinations in Lewy body dementia.
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  123. LEVEY AI, Qiu D, Zhao L, Hu WT, et al
    A phase II study repurposing atomoxetine for neuroprotection in mild cognitive impairment.
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  124. TANNER JA, Iaccarino L, Edwards L, Asken BM, et al
    Amyloid, tau and metabolic PET correlates of cognition in early and late-onset Alzheimer's disease.
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  125. KAIVOLA K, Shah Z, Chia R, Scholz SW, et al
    Genetic evaluation of dementia with Lewy bodies implicates distinct disease subgroups.
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    May 2022
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    What plasma biomarkers tell us about hippocampal microstructural changes in Alzheimer's disease.
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  127. DUZEL E, Ziegler G, Berron D, Maass A, et al
    Amyloid pathology but not APOE epsilon4 status is permissive for tau-related hippocampal dysfunction.
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  128. KO H, Kim S, Kim K, Jung SH, et al
    Genome-wide association study of occupational attainment as a proxy for cognitive reserve.
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  129. MORRIS JC, Weiner M, Xiong C, Beckett L, et al
    Autosomal dominant and sporadic late onset Alzheimer disease share a common in vivo pathophysiology.
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  130. MORRISON MS, Aparicio HJ, Blennow K, Zetterberg H, et al
    Antemortem plasma phosphorylated tau (181) predicts Alzheimer's disease neuropathology and regional tau at autopsy.
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  131. Correction to: Brain amyloid-beta oligomers in ageing and Alzheimer's disease.
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  132. EISSMAN JM, Dumitrescu L, Mahoney ER, Smith AN, et al
    Sex differences in the genetic architecture of cognitive resilience to Alzheimer's disease.
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  133. ZHU WM, Neuhaus A, Beard DJ, Sutherland BA, et al
    Neurovascular coupling mechanisms in health and neurovascular uncoupling in Alzheimer's disease.
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  134. VROMEN EM, de Boer SCM, Teunissen CE, Rozemuller A, et al
    Biomarker A+T-: is this Alzheimer's disease or not? A combined CSF and pathology study.
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    April 2022
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    Proposed research criteria for prodromal behavioural variant frontotemporal dementia.
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  136. LEGAZ A, Abrevaya S, Dottori M, Gonzalez Campo C, et al
    Multimodal mechanisms of human socially reinforced learning across neurodegenerative diseases.
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  137. MESULAM MM, Coventry CA, Bigio EH, Sridhar J, et al
    Neuropathological fingerprints of survival, atrophy and language in primary progressive aphasia.
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  138. SHAHID SS, Wen Q, Risacher SL, Farlow MR, et al
    Hippocampal-subfield microstructures and their relation to plasma biomarkers in Alzheimer's disease.
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  139. OLIVEROS G, Wallace CH, Chaudry O, Liu Q, et al
    Repurposing ibudilast to mitigate Alzheimer's disease by targeting inflammation.
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  140. STEVENSON-HOARE J, Heslegrave A, Leonenko G, Fathalla D, et al
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  141. PADHI S, Sarangi S, Nayak N, Pati A, et al
    OAS1 rs1131454 genetic variant is associated with Alzheimer's disease: an epidemiological analysis.
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    March 2022
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    Broad activation of the Parkin pathway induces synaptic mitochondrial deficits in early tauopathy.
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  143. BENATAR M, Wuu J, McHutchison C, Postuma RB, et al
    Preventing amyotrophic lateral sclerosis: insights from pre-symptomatic neurodegenerative diseases.
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  144. HOSOKAWA M, Masuda-Suzukake M, Shitara H, Shimozawa A, et al
    Development of a novel tau propagation mouse model endogenously expressing 3 and 4 repeat tau isoforms.
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  145. GIACOBINI E, Cuello AC, Fisher A
    Reimagining cholinergic therapy for Alzheimer's disease.
    Brain. 2022 Mar 15. pii: 6548684. doi: 10.1093.
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  146. SHETTY AK
    Can rapamycin slow down memory decline in Alzheimer's disease with seizures?
    Brain. 2022 Mar 12. pii: 6547363. doi: 10.1093.
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  147. LAM AD, Shafi MM
    Towards a coherent view of network hyperexcitability in Alzheimer's disease.
    Brain. 2022 Mar 8. pii: 6544859. doi: 10.1093.
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  148. LIN CP, Frigerio I, Boon BDC, Zhou Z, et al
    Structural (dys)connectivity associates with cholinergic cell density in Alzheimer's disease.
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  149. GABRIELLI M, Prada I, Joshi P, Falcicchia C, et al
    Microglial large extracellular vesicles propagate early synaptic dysfunction in Alzheimer's disease.
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    February 2022
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    Blood-brain barrier permeable beta-blockers linked to lower risk of Alzheimer's disease in hypertension.
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  151. PERIS L, Parato J, Qu X, Soleilhac JM, et al
    Tubulin tyrosination regulates synaptic function and is disrupted in Alzheimer's disease.
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    January 2022
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    Cancer diagnosis is associated with a lower burden of dementia and less Alzheimer's-type neuropathology.
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  153. WIESMAN AI, Murman DL, Losh RA, Schantell M, et al
    Spatially resolved neural slowing predicts impairment and amyloid burden in Alzheimer's disease.
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  154. MARTINO ADAMI PV, Orellana A, Garcia P, Kleineidam L, et al
    Matrix metalloproteinase 10 is linked to the risk of progression to dementia of the Alzheimer's type.
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  155. STERN AM, Liu L, Jin S, Liu W, et al
    A calcium-sensitive antibody isolates soluble amyloid-beta aggregates and fibrils from Alzheimer's disease brain.
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  156. ALI M, Falkenhain K, Njiru BN, Murtaza-Ali M, et al
    VEGF signalling causes stalls in brain capillaries and reduces cerebral blood flow in Alzheimer's mice.
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  157. BRIDEL C, Somers C, Sieben A, Rozemuller A, et al
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  158. COOMANS EM, Tomassen J, Ossenkoppele R, Golla SSV, et al
    Genetically identical twins show comparable tau PET load and spatial distribution.
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    December 2021
  159. LEE Y, Miller MR, Fernandez MA, Berg EL, et al
    Early lysosome defects precede neurodegeneration with amyloid-beta and tau aggregation in NHE6-null rat brain.
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  160. RANASINGHE KG, Kudo K, Hinkley L, Beagle A, et al
    Neuronal synchrony abnormalities associated with subclinical epileptiform activity in early onset Alzheimer's disease.
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  161. XHIMA K, Markham-Coultes K, Kofoed RH, Saragovi HU, et al
    Ultrasound delivery of a TrkA agonist confers neuroprotection to Alzheimer-associated pathologies.
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  162. TSAI HH, Chen YF, Yen RF, Lo YL, et al
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  163. PASCOAL TA, Benedet AL, Tudorascu DL, Therriault J, et al
    Longitudinal 18F-MK-6240 tau tangles accumulation follows Braak stages.
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  164. ABRAHAMSON EE, Kofler JK, Becker CR, Price JC, et al
    11C-PiB PET can underestimate brain amyloid-beta burden when cotton wool plaques are numerous.
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    November 2021
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    Beyond the average patient: how neuroimaging models can address heterogeneity in dementia.
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    October 2021
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    Amyloid-beta toxicity modulates tau phosphorylation through the PAX6 signalling pathway.
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  167. LUCEY BP, Wisch J, Boerwinkle AH, Landsness EC, et al
    Sleep and longitudinal cognitive performance in preclinical and early symptomatic Alzheimer's disease.
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  168. LEVY JP, Bezgin G, Savard M, Pascoal TA, et al
    18F-MK-6240 tau-PET in genetic frontotemporal dementia.
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  169. MAGUSALI N, Graham AC, Piers TM, Panichnantakul P, et al
    A genetic link between risk for Alzheimer's disease and severe COVID-19 outcomes via the OAS1 gene.
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  170. KHAN AF, Adewale Q, Baumeister TR, Carbonell F, et al
    Personalized brain models identify neurotransmitter receptor changes in Alzheimer's disease.
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  171. SCHUMACHER J, Ray NJ, Hamilton CA, Donaghy PC, et al
    Cholinergic white matter pathways in dementia with Lewy bodies and Alzheimer's disease.
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    September 2021

  172. Erratum to: Cardiovascular brain impulses in Alzheimer's disease.
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  173. STOTHART G, Smith LJ, Milton A, Coulthard E, et al
    A passive and objective measure of recognition memory in Alzheimer's disease using Fastball memory assessment.
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    August 2021
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    Towards a comprehensive 3D mapping of tau progression in early Alzheimer's disease.
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  175. DAVILA-BOUZIGUET E, Casoliba-Melich A, Targa-Fabra G, Galera-Lopez L, et al
    Functional protection in J20/VLW mice: a model of non-demented with Alzheimer's disease neuropathology.
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  176. BOYLE PA, Wang T, Yu L, Wilson RS, et al
    To what degree is late life cognitive decline driven by age-related neuropathologies?
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  177. HOLLAND N, Malpetti M, Rittman T, Mak EE, et al
    Molecular pathology and synaptic loss in primary tauopathies: an 18F-AV-1451 and 11C-UCB-J PET study.
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  178. STROM A, Iaccarino L, Edwards L, Lesman-Segev OH, et al
    Cortical hypometabolism reflects local atrophy and tau pathology in symptomatic Alzheimer's disease.
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    July 2021
  179. PAUMIER A, Boisseau S, Jacquier-Sarlin M, Pernet-Gallay K, et al
    Astrocyte-neuron interplay is critical for Alzheimer's disease pathogenesis and is rescued by TRPA1 channel blockade.
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  180. GOURMAUD S, Stewart DA, Irwin DJ, Roberts N, et al
    The role of mTORC1 activation in seizure-induced exacerbation of Alzheimer's disease.
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  181. BERRON D, van Westen D, Ossenkoppele R, Strandberg O, et al
    Corrigendum to: Medial temporal lobe connectivity and its associations with cognition in early Alzheimer's disease.
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  182. PEREIRA JB, Janelidze S, Smith R, Mattsson-Carlgren N, et al
    Plasma GFAP is an early marker of amyloid-beta but not tau pathology in Alzheimer's disease.
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  183. BAILES SM, Lewis LD
    Distinct cardiac-locked brain pulsations in Alzheimer's disease.
    Brain. 2021 Jul 9. pii: 6318392. doi: 10.1093.
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  184. HORIE K, Barthelemy NR, Sato C, Bateman RJ, et al
    Corrigendum to: CSF tau microtubule binding region identifies tau tangle and clinical stages of Alzheimer's disease.
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    June 2021
  185. RIES M, Watts H, Mota BC, Lopez MY, et al
    Annexin A1 restores cerebrovascular integrity concomitant with reduced amyloid-beta and tau pathology.
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  186. MATTHEWS DC, Mao X, Dowd K, Tsakanikas D, et al
    Riluzole, a glutamate modulator, slows cerebral glucose metabolism decline in patients with Alzheimer's disease.
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  187. PATEL AG, Nehete PN, Krivoshik SR, Pei X, et al
    Innate immunity stimulation via CpG oligodeoxynucleotides ameliorates Alzheimer's disease pathology in aged squirrel monkeys.
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  188. SCHUMACHER J, Gunter JL, Przybelski SA, Jones DT, et al
    Dementia with Lewy bodies: association of Alzheimer pathology with functional connectivity networks.
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    May 2021

  189. Erratum to: The development and convergence of co-pathologies in Alzheimer's disease.
    Brain. 2021 May 23. pii: 6282423. doi: 10.1093.
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  190. DEHGHANI N, Bras J, Guerreiro R
    Erratum to: How understudied populations have contributed to our understanding of Alzheimer's disease genetics.
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    April 2021
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    Plasma amyloid-beta ratios in autosomal dominant Alzheimer's disease: the influence of genotype.
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  192. DEHGHANI N, Bras J, Guerreiro R
    How understudied populations have contributed to our understanding of Alzheimer's disease genetics.
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  193. YAO Y, Kang SS, Xia Y, Wang ZH, et al
    A delta-secretase-truncated APP fragment activates CEBPB, mediating Alzheimer's disease pathologies.
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  194. Erratum to: Time course of phosphorylated-tau181 in blood across the Alzheimer's disease spectrum.
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  195. OZAWA S, Hori Y, Shimizu Y, Taniguchi A, et al
    Photo-oxygenation by a biocompatible catalyst reduces amyloid-beta levels in Alzheimer's disease mice.
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  196. TOME SO, Thal DR
    Co-pathologies in Alzheimer's disease: just multiple pathologies or partners in crime?
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  197. Corrigendum to: Monitoring the progression of Alzheimer's disease with tau-PET.
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    March 2021
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    Cardiovascular brain impulses in Alzheimer's disease.
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  199. YAP SY, Frias B, Wren MC, Scholl M, et al
    Discriminatory ability of next-generation tau PET tracers for Alzheimer's disease.
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  200. EWERS M, Luan Y, Frontzkowski L, Neitzel J, et al
    Segregation of functional networks is associated with cognitive resilience in Alzheimer's disease.
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  201. ASBY D, Boche D, Allan S, Love S, et al
    Systemic infection exacerbates cerebrovascular dysfunction in Alzheimer's disease.
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  202. SPINA S, La Joie R, Petersen C, Nolan AL, et al
    Comorbid neuropathological diagnoses in early versus late-onset Alzheimer's disease.
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  203. HUSAIN M
    Blood tests to screen for Alzheimer's disease.
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  204. KIM JH, Afridi R, Han J, Jung HG, et al
    Gamma subunit of complement component 8 is a neuroinflammation inhibitor.
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    February 2021
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    Integrating events in the disintegration of Alzheimer's disease.
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  206. TIJMS BM, Teunissen CE
    Concatenating plasma p-tau to Alzheimer's disease.
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    January 2021
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    Population-based blood screening for preclinical Alzheimer's disease in a British birth cohort at age 70.
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  208. Erratum to: Alzheimer's disease brain-derived extracellular vesicles spread tau pathology in interneurons.
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    December 2020
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    Hearing and dementia: from ears to brain.
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  210. MONTERO-CRESPO M, Dominguez-Alvaro M, Alonso-Nanclares L, DeFelipe J, et al
    Three-dimensional analysis of synaptic organization in the hippocampal CA1 field in Alzheimer's disease.
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  211. HORIE K, Barthelemy NR, Sato C, Bateman RJ, et al
    CSF tau microtubule binding region identifies tau tangle and clinical stages of Alzheimer's disease.
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  212. TEUNISSEN CE, Thijssen EH, Verberk IMW
    Plasma p-tau217: from 'new kid' to most promising candidate for Alzheimer's disease blood test.
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  213. PEREIRA JB, Janelidze S, Ossenkoppele R, Kvartsberg H, et al
    Untangling the association of amyloid-beta and tau with synaptic and axonal loss in Alzheimer's disease.
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  214. TIJMS BM, Gobom J, Reus L, Jansen I, et al
    Pathophysiological subtypes of Alzheimer's disease based on cerebrospinal fluid proteomics.
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  215. SMITH R, Strandberg O, Mattsson-Carlgren N, Leuzy A, et al
    The accumulation rate of tau aggregates is higher in females and younger amyloid-positive subjects.
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  216. FLORES-AGUILAR L, Iulita MF, Kovecses O, Torres MD, et al
    Evolution of neuroinflammation across the lifespan of individuals with Down syndrome.
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    November 2020
  217. MOSCOSO A, Grothe MJ, Ashton NJ, Karikari TK, et al
    Time course of phosphorylated-tau181 in blood across the Alzheimer's disease spectrum.
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  218. BRIER MR, Day GS
    Serum neurofilament light chain uncovers neurodegeneration early in the course of Alzheimer's disease.
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  219. SUR C, Kost J, Scott D, Adamczuk K, et al
    BACE inhibition causes rapid, regional, and non-progressive volume reduction in Alzheimer's disease brain.
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  220. RUAN Z, Pathak D, Venkatesan Kalavai S, Yoshii-Kitahara A, et al
    Alzheimer's disease brain-derived extracellular vesicles spread tau pathology in interneurons.
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  221. BENEDET AL, Leuzy A, Pascoal TA, Ashton NJ, et al
    Stage-specific links between plasma neurofilament light and imaging biomarkers of Alzheimer's disease.
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  222. JIA L, Li F, Wei C, Zhu M, et al
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  223. LIU KY, Reeves S, McAleese KE, Attems J, et al
    Neuropsychiatric symptoms in limbic-predominant age-related TDP-43 encephalopathy and Alzheimer's disease.
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  224. JI X, Liu G
    rs34331204 regulates TSPAN13 expression and contributes to Alzheimer's disease with sex differences.
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  225. DUMITRESCU L, Hohman TJ
    Reply: rs34331204 regulates TSPAN13 expression and contributes to Alzheimer's disease with sex differences.
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  226. JOSEPHS KA, Martin PR, Weigand SD, Tosakulwong N, et al
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  227. SOLEIMANI-MEIGOONI DN, Iaccarino L, La Joie R, Baker S, et al
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    October 2020
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    September 2020
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    July 2020
  230. PASCOAL TA, Therriault J, Benedet AL, Savard M, et al
    18F-MK-6240 PET for early and late detection of neurofibrillary tangles.
    Brain. 2020 Jul 16. pii: 5872095. doi: 10.1093.
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    June 2020
  231. PRZYBYLA M, van Eersel J, van Hummel A, van der Hoven J, et al
    Onset of hippocampal network aberration and memory deficits in P301S tau mice are associated with an early gene signature.
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    January 2020
  232. ROBINSON JL, Richardson H, Xie SX, Suh E, et al
    The development and convergence of co-pathologies in Alzheimer's disease.
    Brain. 2020 Jan 15. pii: 6101614. doi: 10.1093.
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