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Articles published in
Toxicol Sci
    September 2025
  1. REINA-GONZALEZ P, Ay M, Langley M, Plunk E, et al
    Neurotoxicants driving glial aging: role of astrocytic aging in non-cell autonomous neurodegeneration.
    Toxicol Sci. 2025;207:20-28.
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    June 2025
  2. POOLE LG, Wei Z, Schulte A, Cline HM, et al
    Kupffer cell expression of macrophage receptor with collagenous structure modulates macrophage gene induction and limits acute liver injury.
    Toxicol Sci. 2025;205:417-427.
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  3. LIU X, Wang K, Zhang X, Qi J, et al
    Gallic acid relieved bortezomib-induced peripheral neurotoxicity by restoring Schwann cell lysosomal activity.
    Toxicol Sci. 2025;205:297-309.
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  4. ALI NA, Kennon-McGill S, Parker LD, James LP, et al
    NAPQI is absent in the mouse brain after sub-hepatotoxic and hepatotoxic doses of acetaminophen.
    Toxicol Sci. 2025;205:274-278.
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  5. NEWELL AJ, Patisaul HB
    Modeling the developing nervous system: a neuroscience perspective on the use of new approach methodologies in developmental neurotoxicity testing.
    Toxicol Sci. 2025;205:245-273.
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    May 2025
  6. SANCHEZ-GUERRERO G, Umbaugh DS, Smith SH, Akakpo JY, et al
    Mixed lineage kinase domain-like protein deficiency exacerbates early injury in a mouse model of acetaminophen hepatotoxicity.
    Toxicol Sci. 2025;205:220-232.
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  7. BEAMISH CR, Becker J, Tam LM, Love T, et al
    Transcriptomic analysis identifies muscle-specific mitochondrial and vesicular transport genes as methylmercury toxicity targets in a Drosophila model of congenital Minamata disease.
    Toxicol Sci. 2025;205:106-123.
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    April 2025
  8. BAJAJ P, Brennan RJ, Laurent S, Sauzeat S, et al
    Transcriptomic analysis in liver spheroids identifies a dog-specific mechanism of hepatotoxicity for amcenestrant.
    Toxicol Sci. 2025;204:228-241.
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  9. PANNALA VR, Hari A, AbdulHameed MDM, Balik-Meisner MR, et al
    Quantifying liver-toxic responses from dose-dependent chemical exposures using a rat genome-scale metabolic model.
    Toxicol Sci. 2025;204:154-168.
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  10. SHINOZAWA T, Miyamoto K, Baker KS, Faber SC, et al
    TAK-994 mechanistic investigation into drug-induced liver injury.
    Toxicol Sci. 2025;204:143-153.
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    January 2025
  11. LIVOTI LA, Sison-Young R, Reddyhoff D, Fisher CP, et al
    Limitations of acetaminophen as a reference hepatotoxin for the evaluation of in vitro liver models.
    Toxicol Sci. 2025;203:35-40.
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  12. HAMMOND S, Meng X, Barber J, Mosedale M, et al
    Tolvaptan safety in autosomal-dominant polycystic kidney disease; a focus on idiosyncratic drug-induced liver injury liabilities.
    Toxicol Sci. 2025;203:11-27.
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  13. FAS L, Chen M, Tong W, Wenz F, et al
    Physiological liver microtissue 384-well microplate system for preclinical hepatotoxicity assessment of therapeutic small molecule drugs.
    Toxicol Sci. 2025;203:79-87.
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    October 2024
  14. KRAMER NE, Fillmore CE, Slane EG, Barnett LMA, et al
    Insights into brominated flame retardant neurotoxicity: mechanisms of hippocampal neural cell death and brain region-specific transcriptomic shifts in mice.
    Toxicol Sci. 2024;201:282-299.
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    September 2024
  15. ZHAO Y, Park JY, Yang D, Zhang M, et al
    A computational framework to in silico screen for drug-induced hepatocellular toxicity.
    Toxicol Sci. 2024;201:14-25.
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    August 2024
  16. CHO T, Hayes A, Henderson JT, Uetrecht J, et al
    The use of PD-1 functional knockout rats to study idiosyncratic adverse reactions to nevirapine.
    Toxicol Sci. 2024;200:382-393.
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  17. BURON N, Porceddu M, Loyant R, Martel C, et al
    Drug-induced impairment of mitochondrial fatty acid oxidation and steatosis: assessment of causal relationship with 45 pharmaceuticals.
    Toxicol Sci. 2024;200:369-381.
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  18. MEZENCEV R, Feshuk M, Kolaczkowski L, Peterson GC, et al
    The association between histopathologic effects and liver weight changes induced in mice and rats by chemical exposures: an analysis of the data from Toxicity Reference Database (ToxRefDB).
    Toxicol Sci. 2024;200:404-413.
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    June 2024
  19. JEE A, Sernoskie SC, Uetrecht J
    The role of corticosterone in nevirapine-induced idiosyncratic drug-induced liver injury.
    Toxicol Sci. 2024;200:146-164.
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    May 2024
  20. SCULLION KM, MacIntyre IM, Sloan-Dennison S, Clark B, et al
    Cytokeratin-18 is a sensitive biomarker of alanine transaminase increase in a placebo-controlled, randomized, crossover trial of therapeutic paracetamol dosing (PATH-BP biomarker substudy).
    Toxicol Sci. 2024;199:203-209.
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    March 2024
  21. AKAKPO JY, Olivos H, Shrestha B, Midey A, et al
    Spatial analysis of renal acetaminophen metabolism and its modulation by 4-methylpyrazole with DESI mass spectrometry imaging.
    Toxicol Sci. 2024;198:328-346.
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    February 2024
  22. TAKIMOTO N, Ishii Y, Mitsumoto T, Takasu S, et al
    Formation of hepatocyte cytoplasmic inclusions and their contribution to methylcarbamate-induced hepatocarcinogenesis in F344 rats.
    Toxicol Sci. 2024;198:40-49.
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  23. XU C, Yan F, Zhao Y, Jaeschke H, et al
    Hepatocyte miR-21-5p-deficiency alleviates APAP-induced liver injury by inducing PPARgamma and autophagy.
    Toxicol Sci. 2024;198:50-60.
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  24. O'SHAUGHNESSY KL, Sasser AL, Bell KS, Riutta C, et al
    Bypassing the brain barriers: upregulation of serum miR-495 and miR-543-3p reflects thyroid-mediated developmental neurotoxicity in the rat.
    Toxicol Sci. 2024;198:128-140.
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  25. WIJAYA LS, Gabor A, Pot IE, van de Have L, et al
    A network-based transcriptomic landscape of HepG2 cells uncovering causal gene-cytotoxicity interactions underlying drug-induced liver injury.
    Toxicol Sci. 2024;198:14-30.
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    December 2023
  26. GHOSH P, Magee N, Akakpo JY, Ahamed F, et al
    Hepatocyte-specific deletion of small heterodimer partner protects mice against acetaminophen-induced hepatotoxicity via activation of Nrf2.
    Toxicol Sci. 2023;197:53-68.
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  27. OGESE MO, Lister A, Farrell L, Gardner J, et al
    A blinded in vitro analysis of the intrinsic immunogenicity of hepatotoxic drugs: implications for preclinical risk assessment.
    Toxicol Sci. 2023;197:38-52.
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    October 2023
  28. RUSSOMANNO G, Sison-Young R, Livoti LA, Coghlan H, et al
    A systems approach reveals species differences in hepatic stress response capacity.
    Toxicol Sci. 2023;196:112-125.
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    September 2023
  29. FERGANY A, Zong C, Ekuban FA, Suzuki A, et al
    Deletion of IL-1beta exacerbates acrylamide-induced neurotoxicity in mice.
    Toxicol Sci. 2023;195:246-256.
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    July 2023
  30. ZHUO X, Howell BA, Shen H, Woodhead JL, et al
    Mechanistic investigation of liver injury induced by BMS-932481, an experimental ɣ-secretase modulator.
    Toxicol Sci. 2023;194:235-245.
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    March 2023
  31. ALI SE, Waddington JC, Lister A, Sison-Young R, et al
    Identification of flucloxacillin-modified hepatocellular proteins: implications in flucloxacillin-induced liver injury.
    Toxicol Sci. 2023;192:106-116.
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  32. MAASS C, Schaller S, Dallmann A, Bothe K, et al
    Considering developmental neurotoxicity in vitro data for human health risk assessment using physiologically-based kinetic modeling: deltamethrin case study.
    Toxicol Sci. 2023;192:59-70.
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