November 2025
1. CHEN SC
   Reevaluating Mega-Dose Esomeprazole in Sepsis: Implications of Comparator Exposure and Comorbidity Imbalance.
   Crit Care Med. 2025;53:e2372-e2373.
   

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   June 2025
2. DEANE AM
   Proton Pump Inhibitors and the Upside Down.
   Crit Care Med. 2025 Jun 12. doi: 10.1097/CCM.0000000000006747.
   

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   May 2025
3. MONTI G, Carta S, Kotani Y, Bruni A, et al
   A Multinational Randomized Trial of Mega-Dose Esomeprazole As Anti-Inflammatory Agent in Sepsis.
   Crit Care Med. 2025 May 29. doi: 10.1097/CCM.0000000000006720.
   

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   April 2025
4. LI H, Zeng L, Xu P, Olsen K, et al
   Effectiveness of a Pharmacist-Led Intervention to Reduce Acid Suppression Therapy for Stress Ulcer Prophylaxis in ICUs in China: A Multicenter, Stepped-Wedge, Cluster-Randomized Controlled Trial.
   Crit Care Med. 2025;53:e805-e816.
   

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   November 2024
5. KRANAWETTER B, Brockmoller J, Sindern J, Hapke A, et al
   Intestinal Drug Absorption After Subarachnoid Hemorrhage and Elective Neurosurgery: Insights From Esomeprazole Pharmacokinetics.
   Crit Care Med. 2024 Nov 21. doi: 10.1097/CCM.0000000000006512.
   

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   February 2024
6. CASAL GL, Bittner EA
   Pump the Breaks on the Slide to Harm From Nonindicated Proton Pump Inhibitors After Critical Illness!
   Crit Care Med. 2024;52:334-337.
   

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7. PALMOWSKI L, von Busch A, Unterberg M, Bergmann L, et al
   Timely Cessation of Proton Pump Inhibitors in Critically Ill Patients Impacts Morbidity and Mortality: A Propensity Score-Matched Cohort Study.
   Crit Care Med. 2024;52:190-199.
   

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