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Parkinson's Disease
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Articles published in
Proc Natl Acad Sci U S A
    September 2025
  1. RODRIGUEZ JA, Minis A, Aref R, Nguyen HHM, et al
    PI31 expression is neuroprotective in a mouse model of early-onset parkinsonism.
    Proc Natl Acad Sci U S A. 2025;122:e2511899122.
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    August 2025
  2. FERGUSON SM
    Derailed degradation: LRRK2-dependent exocytosis in Parkinson's disease.
    Proc Natl Acad Sci U S A. 2025;122:e2515758122.
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  3. NAIR SV, Jaimon E, Adhikari A, Nikoloff J, et al
    Lysosomal glucocerebrosidase is needed for ciliary Hedgehog signaling: A convergent pathway contributing to Parkinson's disease.
    Proc Natl Acad Sci U S A. 2025;122:e2504774122.
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    July 2025
  4. RONTGEN A, Toprakcioglu Z, Morris OM, Vendruscolo M, et al
    Amyloid-beta modulates the phase separation and aggregation of alpha-synuclein.
    Proc Natl Acad Sci U S A. 2025;122:e2501987122.
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  5. PALUMBOS SD, Popolow J, Goldsmith J, Holzbaur ELF, et al
    Autophagic stress activates distinct compensatory secretory pathways in neurons.
    Proc Natl Acad Sci U S A. 2025;122:e2421886122.
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    May 2025

  6. Correction for Masliah et al., beta-Amyloid peptides enhance alpha-synuclein accumulation and neuronal deficits in a transgenic mouse model linking Alzheimer's disease and Parkinson's disease.
    Proc Natl Acad Sci U S A. 2025;122:e2509530122.
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    April 2025
  7. SONDERMANN P, Diercks CS, Rong C, Schultz PG, et al
    Targeted degradation of alpha-Synuclein using an evolved botulinum toxin protease.
    Proc Natl Acad Sci U S A. 2025;122:e2426745122.
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    February 2025
  8. BAGNOLI E, Lin YE, Burel S, Jaimon E, et al
    Endogenous LRRK2 and PINK1 function in a convergent neuroprotective ciliogenesis pathway in the brain.
    Proc Natl Acad Sci U S A. 2025;122:e2412029122.
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    November 2024
  9. GILBOA T, Ter-Ovanesyan D, Wang SC, Whiteman S, et al
    Measurement of alpha-synuclein as protein cargo in plasma extracellular vesicles.
    Proc Natl Acad Sci U S A. 2024;121:e2408949121.
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    October 2024
  10. WILLIAMS D, Glasstetter LM, Jong TT, Chen T, et al
    High-throughput screening for small-molecule stabilizers of misfolded glucocerebrosidase in Gaucher disease and Parkinson's disease.
    Proc Natl Acad Sci U S A. 2024;121:e2406009121.
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  11. COLEMAN CR, Pallos J, Arreola-Bustos A, Wang L, et al
    Natural variation in age-related dopamine neuron degeneration is glutathione dependent and linked to life span.
    Proc Natl Acad Sci U S A. 2024;121:e2403450121.
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    September 2024
  12. WANG X, Geng J, Rimal S, Sui Y, et al
    The p53 target DRAM1 modulates calcium homeostasis and ER stress by promoting contact between lysosomes and the ER through STIM1.
    Proc Natl Acad Sci U S A. 2024;121:e2400531121.
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  13. Correction to Supporting Information for Woerman et al., Familial Parkinson's point mutation abolishes multiple system atrophy prion replication.
    Proc Natl Acad Sci U S A. 2024;121:e2417229121.
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  14. URIBE-CANO S, Kottmann AH
    The primary cilium of cholinergic neurons may be a linchpin in the progression of Parkinson's Disease.
    Proc Natl Acad Sci U S A. 2024;121:e2414226121.
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  15. KIM Y, McInnes J, Kim J, Liang YHW, et al
    Olfactory deficit and gastrointestinal dysfunction precede motor abnormalities in alpha-Synuclein G51D knock-in mice.
    Proc Natl Acad Sci U S A. 2024;121:e2406479121.
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  16. Correction to Supporting Information for Chen et al., Parkinson's disease-linked D620N VPS35 knockin mice manifest tau neuropathology and dopaminergic neurodegeneration.
    Proc Natl Acad Sci U S A. 2024;121:e2416001121.
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    August 2024
  17. LIU K, Tao Y, Zhao Q, Xia W, et al
    Binding adaptability of chemical ligands to polymorphic alpha-synuclein amyloid fibrils.
    Proc Natl Acad Sci U S A. 2024;121:e2321633121.
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  18. DEWISON KM, Rowlinson B, Machin JM, Crossley JA, et al
    Residues 2 to 7 of alpha-synuclein regulate amyloid formation via lipid-dependent and lipid-independent pathways.
    Proc Natl Acad Sci U S A. 2024;121:e2315006121.
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  19. ROSENKRANTZ JL, Brandorff JE, Raghib S, Kapadia A, et al
    ZNF91 is an endogenous repressor of the molecular phenotype associated with X-linked dystonia-parkinsonism (XDP).
    Proc Natl Acad Sci U S A. 2024;121:e2401217121.
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  20. KHAN SS, Jaimon E, Lin YE, Nikoloff J, et al
    Loss of primary cilia and dopaminergic neuroprotection in pathogenic LRRK2-driven and idiopathic Parkinson's disease.
    Proc Natl Acad Sci U S A. 2024;121:e2402206121.
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  21. CONNELLY EM, Rintala-Dempsey AC, Gundogdu M, Freeman EA, et al
    Capturing the catalytic intermediates of parkin ubiquitination.
    Proc Natl Acad Sci U S A. 2024;121:e2403114121.
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    July 2024
  22. HOY CW, de Hemptinne C, Wang SS, Harmer CJ, et al
    Beta and theta oscillations track effort and previous reward in the human basal ganglia and prefrontal cortex during decision making.
    Proc Natl Acad Sci U S A. 2024;121:e2322869121.
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  23. GUPTA S, Tielemans A, Guevara CA, Huntley GW, et al
    Parkinson's-linked LRRK2-G2019S derails AMPAR trafficking, mobility, and composition in striatum with cell-type and subunit specificity.
    Proc Natl Acad Sci U S A. 2024;121:e2317833121.
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  24. Correction for Ahuja et al., Bach1 derepression is neuroprotective in a mouse model of Parkinson's disease.
    Proc Natl Acad Sci U S A. 2024;121:e2411303121.
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    June 2024

  25. Correction for Prusiner et al., Evidence for alpha-synuclein prions causing multiple system atrophy in humans with parkinsonism.
    Proc Natl Acad Sci U S A. 2024;121:e2408899121.
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    May 2024
  26. CAI W, Young CB, Yuan R, Lee B, et al
    Subthalamic nucleus-language network connectivity predicts dopaminergic modulation of speech function in Parkinson's disease.
    Proc Natl Acad Sci U S A. 2024;121:e2316149121.
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    April 2024
  27. MOHD RAFIQ N, Fujise K, Rosenfeld MS, Xu P, et al
    Parkinsonism Sac domain mutation in Synaptojanin-1 affects ciliary properties in iPSC-derived dopaminergic neurons.
    Proc Natl Acad Sci U S A. 2024;121:e2318943121.
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    February 2024
  28. RILEY MJ, Mitchell CC, Ernst SE, Taylor EB, et al
    A model for stimulation of enzyme activity by a competitive inhibitor based on the interaction of terazosin and phosphoglycerate kinase 1.
    Proc Natl Acad Sci U S A. 2024;121:e2318956121.
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  29. RONTGEN A, Toprakcioglu Z, Tomkins JE, Vendruscolo M, et al
    Modulation of alpha-synuclein in vitro aggregation kinetics by its alternative splice isoforms.
    Proc Natl Acad Sci U S A. 2024;121:e2313465121.
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    January 2024
  30. GILBOA T, Swank Z, Thakur R, Gould RA, et al
    Toward the quantification of alpha-synuclein aggregates with digital seed amplification assays.
    Proc Natl Acad Sci U S A. 2024;121:e2312031121.
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  31. AUBREY LD, Ninkina N, Ulamec SM, Abramycheva NY, et al
    Substitution of Met-38 to Ile in gamma-synuclein found in two patients with amyotrophic lateral sclerosis induces aggregation into amyloid.
    Proc Natl Acad Sci U S A. 2024;121:e2309700120.
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  32. TONG Y, Zhang P, Yang X, Liu X, et al
    Decreasing the intrinsically disordered protein alpha-synuclein levels by targeting its structured mRNA with a ribonuclease-targeting chimera.
    Proc Natl Acad Sci U S A. 2024;121:e2306682120.
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  33. KAKUDA K, Ikenaka K, Kuma A, Doi J, et al
    Lysophagy protects against propagation of alpha-synuclein aggregation through ruptured lysosomal vesicles.
    Proc Natl Acad Sci U S A. 2024;121:e2312306120.
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    December 2023
  34. QI C, Verheijen BM, Kokubo Y, Shi Y, et al
    Tau filaments from amyotrophic lateral sclerosis/parkinsonism-dementia complex adopt the CTE fold.
    Proc Natl Acad Sci U S A. 2023;120:e2306767120.
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    November 2023
  35. BODILY TA, Ramanathan A, Wei S, Karkisaval A, et al
    In pursuit of degenerative brain disease diagnosis: Dementia biomarkers detected by DNA aptamer-attached portable graphene biosensor.
    Proc Natl Acad Sci U S A. 2023;120:e2311565120.
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    October 2023
  36. YESHAW WM, Adhikari A, Chiang CY, Dhekne HS, et al
    Localization of PPM1H phosphatase tunes Parkinson's disease-linked LRRK2 kinase-mediated Rab GTPase phosphorylation and ciliogenesis.
    Proc Natl Acad Sci U S A. 2023;120:e2315171120.
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  37. LAI Y, Zhao C, Tian Z, Wang C, et al
    Neutral lysophosphatidylcholine mediates alpha-synuclein-induced synaptic vesicle clustering.
    Proc Natl Acad Sci U S A. 2023;120:e2310174120.
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  38. WANG X, Espadas J, Wu Y, Cai S, et al
    Membrane remodeling properties of the Parkinson's disease protein LRRK2.
    Proc Natl Acad Sci U S A. 2023;120:e2309698120.
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    September 2023
  39. KIM DY, Shin JY, Lee JE, Kim HN, et al
    A selective ER-phagy exerts neuroprotective effects via modulation of alpha-synuclein clearance in parkinsonian models.
    Proc Natl Acad Sci U S A. 2023;120:e2221929120.
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  40. LE GUEN Y, Luo G, Ambati A, Damotte V, et al
    Multiancestry analysis of the HLA locus in Alzheimer's and Parkinson's diseases uncovers a shared adaptive immune response mediated by HLA-DRB1*04 subtypes.
    Proc Natl Acad Sci U S A. 2023;120:e2302720120.
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    August 2023
  41. YADAVALLI N, Ferguson SM
    LRRK2 suppresses lysosome degradative activity in macrophages and microglia through MiT-TFE transcription factor inhibition.
    Proc Natl Acad Sci U S A. 2023;120:e2303789120.
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    July 2023
  42. ZHANG S, Yi S, Wang L, Li S, et al
    Cyclin-G-associated kinase GAK/dAux regulates autophagy initiation via ULK1/Atg1 in glia.
    Proc Natl Acad Sci U S A. 2023;120:e2301002120.
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    June 2023
  43. MATSUI H, Ito S, Matsui H, Ito J, et al
    Phosphorylation of alpha-synuclein at T64 results in distinct oligomers and exerts toxicity in models of Parkinson's disease.
    Proc Natl Acad Sci U S A. 2023;120:e2214652120.
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    April 2023
  44. PENG JY, Qi ZX, Yan Q, Fan XJ, et al
    Ameliorating parkinsonian motor dysfunction by targeting histamine receptors in entopeduncular nucleus-thalamus circuitry.
    Proc Natl Acad Sci U S A. 2023;120:e2216247120.
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  45. SCHWARZ TC, Beier A, Ledolter K, Gossenreiter T, et al
    High-resolution structural information of membrane-bound alpha-synuclein provides insight into the MoA of the anti-Parkinson drug UCB0599.
    Proc Natl Acad Sci U S A. 2023;120:e2201910120.
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    March 2023
  46. CHEUNG THC, Ding Y, Zhuang X, Kang UJ, et al
    Learning critically drives parkinsonian motor deficits through imbalanced striatal pathway recruitment.
    Proc Natl Acad Sci U S A. 2023;120:e2213093120.
    >> Share


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