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Parkinson's Disease
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Articles published in
J Biol Chem
    March 2024
  1. LIU HN, Wang T, Hu JJ, Chen L, et al
    The disordered protein SERF promotes alpha-Synuclein aggregation through liquid-liquid phase separation.
    J Biol Chem. 2024;300:105667.
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    December 2023
  2. PRATT MR, Vocadlo DJ
    Understanding and exploiting the roles of O-GlcNAc in neurodegenerative diseases.
    J Biol Chem. 2023;299:105411.
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  3. ALI A, Zhaliazka K, Dou T, Holman AP, et al
    The toxicities of A30P and A53T alpha-synuclein fibrils can be uniquely altered by the length and saturation of fatty acids in phosphatidylserine.
    J Biol Chem. 2023;299:105383.
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    October 2023
  4. UNAPANTA A, Shavarebi F, Porath J, Shen Y, et al
    Endogenous Rab38 regulates LRRK2's membrane recruitment and substrate Rab phosphorylation in melanocytes.
    J Biol Chem. 2023;299:105192.
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    April 2023
  5. SUN C, Zhou K, DePaola P 4th, Shin WS, et al
    Cryo-EM structure of amyloid fibril formed by alpha-synuclein hereditary A53E mutation reveals a distinct protofilament interface.
    J Biol Chem. 2023;299:104566.
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    March 2023
  6. LEE SH, Lee YJ, Jung S, Chung KC, et al
    E3 ligase adaptor FBXO7 contributes to ubiquitination and proteasomal degradation of SIRT7 and promotes cell death in response to hydrogen peroxide.
    J Biol Chem. 2023;299:102909.
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    December 2022
  7. PIRHAGHI M, Frank SA, Alam P, Nielsen J, et al
    A penetratin-derived peptide reduces the membrane permeabilization and cell toxicity of alpha-synuclein oligomers.
    J Biol Chem. 2022;298:102688.
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  8. WATT KJC, Meade RM, Williams RJ, Mason JM, et al
    Anionic lipid vesicles have differential effects on the aggregation of early onset-associated alpha-synuclein missense mutants.
    J Biol Chem. 2022;298:102565.
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    September 2022
  9. NAGAI-ITO Y, Xu L, Ito K, Kajihara Y, et al
    The atypical Rab GTPase associated with Parkinson's disease, Rab29, is localized to membranes.
    J Biol Chem. 2022 Sep 15:102499. doi: 10.1016/j.jbc.2022.102499.
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  10. LV G, Ko MS, Das T, Eliezer D, et al
    Molecular and functional interactions of alpha-synuclein with Rab3a.
    J Biol Chem. 2022;298:102239.
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    August 2022
  11. CHEDID J, Labrador-Garrido A, Zhong S, Gao J, et al
    A small molecule toll-like receptor antagonist rescues alpha-synuclein fibril pathology.
    J Biol Chem. 2022;298:102260.
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  12. SANDERSON JM
    The association of lipids with amyloid fibrils.
    J Biol Chem. 2022;298:102108.
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    July 2022
  13. FAKIH R, Sauve V, Gehring K
    Structure of the second phosphoubiquitin-binding site in parkin.
    J Biol Chem. 2022;298:102114.
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  14. BHOITE SS, Han Y, Ruotolo BT, Chapman MR, et al
    Mechanistic insights into accelerated alpha-synuclein aggregation mediated by human microbiome-associated functional amyloids.
    J Biol Chem. 2022;298:102088.
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    May 2022
  15. PENA-DIAZ S, Pujols J, Vasili E, Pinheiro F, et al
    The small aromatic compound SynuClean-D inhibits the aggregation and seeded polymerization of multiple alpha-synuclein strains.
    J Biol Chem. 2022;298:101902.
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    January 2022
  16. XU B, Huang S, Liu Y, Wan C, et al
    Manganese promotes alpha-synuclein amyloid aggregation through the induction of protein phase transition.
    J Biol Chem. 2022;298:101469.
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  17. SANGO J, Kakihana T, Takahashi M, Katsuragi Y, et al
    USP10 inhibits the dopamine-induced reactive oxygen species-dependent apoptosis of neuronal cells by stimulating the antioxidant Nrf2 activity.
    J Biol Chem. 2022;298:101448.
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    December 2021
  18. LEE SH, Jung S, Lee YJ, Hyun M, et al
    FBXO7 triggers caspase 8-mediated proteolysis of the transcription factor FOXO4 and exacerbates neuronal cytotoxicity.
    J Biol Chem. 2021;297:101426.
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    October 2021
  19. GANDELMAN M, Dansithong W, Kales SC, Paul S, et al
    The AKT modulator A-443654 reduces alpha-synuclein expression and normalizes ER stress and autophagy.
    J Biol Chem. 2021;297:101191.
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    July 2021
  20. PAN PY, Zhu J, Rizvi A, Zhu X, et al
    Synaptojanin1 deficiency upregulates basal autophagosome formation in astrocytes.
    J Biol Chem. 2021;297:100873.
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    June 2021
  21. AMIREDDY N, Puttapaka SN, Vinnakota RL, Ravuri HG, et al
    Correction: The unintended mitochondrial uncoupling effects of the FDA-approved anti-helminth drug nitazoxanide mitigates experimental parkinsonism in mice.
    J Biol Chem. 2021;297:100864.
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    January 2021
  22. WESTON LJ, Stackhouse TL, Spinelli KJ, Boutros SW, et al
    Genetic deletion of Polo-like kinase 2 reduces alpha-synuclein serine-129 phosphorylation in presynaptic terminals but not Lewy bodies.
    J Biol Chem. 2021;296:100273.
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  23. RAMALINGAM N, Dettmer U
    Temperature is a key determinant of alpha- and beta-synuclein membrane interactions in neurons.
    J Biol Chem. 2021;296:100271.
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    December 2020
  24. CLARK EH, Vazquez de la Torre A, Hoshikawa T, Briston T, et al
    Targeting mitophagy in Parkinson's disease.
    J Biol Chem. 2020 Dec 23:100209. doi: 10.1074/jbc.REV120.014294.
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  25. CLARK EH, Vazquez de la Torre A, Hoshikawa T, Briston T, et al
    Targeting mitophagy in Parkinson's disease.
    J Biol Chem. 2020 Dec 18. pii: REV120.014294. doi: 10.1074/jbc.REV120.014294.
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  26. GUINEY SJ, Adlard PA, Lei P, Mawal CH, et al
    Fibrillar alpha-synuclein toxicity depends on functional lysosomes.
    J Biol Chem. 2020;295:17497-17513.
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    July 2020
  27. LAUTENSCHLAGER J, Wagner-Valladolid S, Stephens AD, Fernandez-Villegas A, et al
    Intramitochondrial proteostasis is directly coupled to alpha-synuclein and amyloid beta1-42 pathologies.
    J Biol Chem. 2020;295:10138-10152.
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    May 2020
  28. LU J, Zhang S, Ma X, Jia C, et al
    Structural basis of the interplay between alpha-synuclein and Tau in regulating pathological amyloid aggregation.
    J Biol Chem. 2020;295:7470-7480.
    >> Share


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