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Articles published in
Proc Natl Acad Sci U S A
    December 2025
  1. PARASKEVAIDI M, Raglan O, McKenzie J, Xiang Y, et al
    Lipidomic profiling of endometrial cancer using desorption electrospray ionization mass spectrometry imaging.
    Proc Natl Acad Sci U S A. 2025;122:e2522839122.
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  2. JIA Q, Zhang J, Song H, Chen J, et al
    Neuroplastin-55 is a receptor of Manf and protects against diet-induced obesity by promoting adipose browning.
    Proc Natl Acad Sci U S A. 2025;122:e2515526122.
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    October 2025
  3. GU L, Du Y, Nazmul Hasan M, Clayton YD, et al
    Adipose cullin 3 mediates the antiobesity effect of pan neddylation inhibitors.
    Proc Natl Acad Sci U S A. 2025;122:e2515947122.
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    September 2025
  4. WEED L, Zeitzer JM
    Circadian-informed modeling predicts regional variation in obesity and stroke outcomes under different permanent US time policies.
    Proc Natl Acad Sci U S A. 2025;122:e2508293122.
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    July 2025
  5. MCGROSKY A, Luke A, Arab L, Bedu-Addo K, et al
    Energy expenditure and obesity across the economic spectrum.
    Proc Natl Acad Sci U S A. 2025;122:e2420902122.
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    May 2025
  6. GUNTER CC, Treadwell DD, Resende MFR Jr, Whitaker VM, et al
    Food Rx: Integrating horticulture research to improve nutrition and health.
    Proc Natl Acad Sci U S A. 2025;122:e2501723122.
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    April 2025
  7. NISHIO M, Yamaguchi K, Otani J, Yuguchi K, et al
    MOB1 deletion in murine mature adipocytes ameliorates obesity and diabetes.
    Proc Natl Acad Sci U S A. 2025;122:e2424741122.
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  8. ARIYANI W, Yoshikawa C, Tsuneoka H, Amano I, et al
    Dopaminergic neurons in the paraventricular hypothalamus extend the food consumption phase.
    Proc Natl Acad Sci U S A. 2025;122:e2411069122.
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  9. CHAIKIN CA, Thakkar AV, Steffeck AWT, Pfrender EM, et al
    Control of circadian muscle glucose metabolism through the BMAL1-HIF axis in obesity.
    Proc Natl Acad Sci U S A. 2025;122:e2424046122.
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    February 2025
  10. BARKER DH, Carskadon MA, Gredvig-Ardito C, Hart CN, et al
    Independent effects of the human circadian system and sleep/eating cycles on caloric intake in adolescents vary by weight status.
    Proc Natl Acad Sci U S A. 2025;122:e2407907122.
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    December 2024
  11. WOODIE LN, Alberto AJ, Krusen BM, Melink LC, et al
    Genetic synchronization of the brain and liver molecular clocks defend against chrono-metabolic disease.
    Proc Natl Acad Sci U S A. 2024;121:e2417678121.
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    November 2024
  12. SCHNEIDER EL, Hangasky JA, Fernandez RDV, Ashley GW, et al
    The limitation of lipidation: Conversion of semaglutide from once-weekly to once-monthly dosing.
    Proc Natl Acad Sci U S A. 2024;121:e2415815121.
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    October 2024
  13. PANDEY A, Ye Y, Wells CR, Singer BH, et al
    Estimating the lives that could be saved by expanded access to weight-loss drugs.
    Proc Natl Acad Sci U S A. 2024;121:e2412872121.
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  14. TANG R, Harasymowicz NS, Wu CL, Choi YR, et al
    Gene therapy for fat-1 prevents obesity-induced metabolic dysfunction, cellular senescence, and osteoarthritis.
    Proc Natl Acad Sci U S A. 2024;121:e2402954121.
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    September 2024
  15. FRIEDMAN JM
    The discovery and development of GLP-1 based drugs that have revolutionized the treatment of obesity.
    Proc Natl Acad Sci U S A. 2024;121:e2415550121.
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    August 2024
  16. DU W, Jiang S, Yin S, Wang R, et al
    The microbiota-dependent tryptophan metabolite alleviates high-fat diet-induced insulin resistance through the hepatic AhR/TSC2/mTORC1 axis.
    Proc Natl Acad Sci U S A. 2024;121:e2400385121.
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    July 2024
  17. LEE J, Wellenstein K, Rahnavard A, Nelson AT, et al
    Beneficial metabolic effects of PAHSAs depend on the gut microbiota in diet-induced obese mice but not in chow-fed mice.
    Proc Natl Acad Sci U S A. 2024;121:e2318691121.
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    May 2024
  18. CHEN J, Liu X, Zou Y, Gong J, et al
    A high-fat diet promotes cancer progression by inducing gut microbiota-mediated leucine production and PMN-MDSC differentiation.
    Proc Natl Acad Sci U S A. 2024;121:e2306776121.
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    April 2024
  19. ORELLANA SC, Bethlehem RAI, Simpson-Kent IL, van Harmelen AL, et al
    Childhood maltreatment influences adult brain structure through its effects on immune, metabolic, and psychosocial factors.
    Proc Natl Acad Sci U S A. 2024;121:e2304704121.
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  20. CUI A, Xue Y, Su W, Lin J, et al
    Glucose regulation of adipose tissue browning by CBP/p300- and HDAC3-mediated reversible acetylation of CREBZF.
    Proc Natl Acad Sci U S A. 2024;121:e2318935121.
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    February 2024
  21. VUJICIC M, Broderick I, Salmantabar P, Perian C, et al
    A macrophage-collagen fragment axis mediates subcutaneous adipose tissue remodeling in mice.
    Proc Natl Acad Sci U S A. 2024;121:e2313185121.
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    January 2024
  22. MUNOZ-ROJAS AR, Wang G, Benoist C, Mathis D, et al
    Adipose-tissue regulatory T cells are a consortium of subtypes that evolves with age and diet.
    Proc Natl Acad Sci U S A. 2024;121:e2320602121.
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  23. GARCIA-LOPEZ MA, Mora A, Corrales P, Pons T, et al
    DIDO is necessary for the adipogenesis that promotes diet-induced obesity.
    Proc Natl Acad Sci U S A. 2024;121:e2300096121.
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  24. YUAN Y, Li K, Ye X, Wen S, et al
    CLCF1 inhibits energy expenditure via suppressing brown fat thermogenesis.
    Proc Natl Acad Sci U S A. 2024;121:e2310711121.
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    December 2023
  25. WU Y, Wu C, Shi T, Cai Q, et al
    FAP expression in adipose tissue macrophages promotes obesity and metabolic inflammation.
    Proc Natl Acad Sci U S A. 2023;120:e2303075120.
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  26. LI M, Macro J, Meadows K, Mishra D, et al
    Late-life shift in caloric intake affects fly metabolism and longevity.
    Proc Natl Acad Sci U S A. 2023;120:e2311019120.
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    September 2023
  27. RAGHANTI MA, Miller EN, Jones DN, Smith HN, et al
    Hedonic eating, obesity, and addiction result from increased neuropeptide Y in the nucleus accumbens during human brain evolution.
    Proc Natl Acad Sci U S A. 2023;120:e2311118120.
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    August 2023
  28. DING M, Xu HY, Zhou WY, Xia YF, et al
    CLCF1 signaling restrains thermogenesis and disrupts metabolic homeostasis by inhibiting mitochondrial biogenesis in brown adipocytes.
    Proc Natl Acad Sci U S A. 2023;120:e2305717120.
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  29. ADAM RC, Pryce DS, Lee JS, Zhao Y, et al
    Activin E-ACVR1C cross talk controls energy storage via suppression of adipose lipolysis in mice.
    Proc Natl Acad Sci U S A. 2023;120:e2309967120.
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  30. FANG LZ, Linehan V, Licursi M, Alberto CO, et al
    Prostaglandin E(2) activates melanin-concentrating hormone neurons to drive diet-induced obesity.
    Proc Natl Acad Sci U S A. 2023;120:e2302809120.
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    May 2023
  31. HOSOYA T, Oba S, Komiya Y, Kawata D, et al
    Apple-shaped obesity: A risky soil for cytokine-accelerated severity in COVID-19.
    Proc Natl Acad Sci U S A. 2023;120:e2300155120.
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    April 2023
  32. BASSE AL, Nielsen KN, Karavaeva I, Ingerslev LR, et al
    NAMPT-dependent NAD(+) biosynthesis controls circadian metabolism in a tissue-specific manner.
    Proc Natl Acad Sci U S A. 2023;120:e2220102120.
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