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Articles published in
J Med Chem
    October 2017
  1. GOOD JAD, Kulen M, Silver J, Krishnan KS, et al
    Thiazolino 2-pyridone amide isosteres as inhibitors of Chlamydia trachomatis infectivity.
    J Med Chem. 2017 Oct 20. doi: 10.1021/acs.jmedchem.7b00716.
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    September 2017
  2. LI X, Hernandez V, Rock FL, Choi W, et al
    Discovery of a Potent and Specific M. tuberculosis Leucyl-tRNA Synthetase Inhibitor: (S)-3-(Aminomethyl)-4-chloro-7-(2-hydroxyethoxy)benzo[c][1,2]oxaborol-1(3H)-ol (GSK656).
    J Med Chem. 2017 Sep 27. doi: 10.1021/acs.jmedchem.7b00631.
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  3. BUCHIERI MV, Cimino M, Rebollo-Ramirez S, Beauvineau C, et al
    Nitazoxanide Analogs Require Nitroreduction for Antimicrobial Activity in Mycobacterium smegmatis.
    J Med Chem. 2017;60:7425-7433.
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  4. CHEN AY, Thomas PW, Stewart AC, Bergstrom A, et al
    Dipicolinic Acid Derivatives as Inhibitors of New Delhi Metallo-beta-lactamase-1.
    J Med Chem. 2017;60:7267-7283.
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  5. ABDEL MONAIM SAH, Ramchuran EJ, El-Faham A, Albericio F, et al
    Converting Teixobactin into a Cationic Antimicrobial Peptide (AMP).
    J Med Chem. 2017;60:7476-7482.
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  6. NI S, Wei H, Li B, Chen F, et al
    Novel Inhibitors of Staphyloxanthin Virulence Factor in Comparison with Linezolid and Vancomycin versus Methicillin-Resistant, Linezolid-Resistant and Vancomycin-Intermediate Staphylococcus aureus Infections in vivo.
    J Med Chem. 2017 Sep 7. doi: 10.1021/acs.jmedchem.7b00949.
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    July 2017
  7. KOZIKOWSKI AP, Onajole OK, Stec J, Dupont C, et al
    Targeting Mycolic Acid Transport by Indole-2-carboxamides for the Treatment of Mycobacterium abscessus Infections.
    J Med Chem. 2017;60:5876-5888.
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    June 2017
  8. PIIZZI G, Parker DT, Peng Y, Dobler M, et al
    Design, Synthesis, and Properties of a Potent Inhibitor of Pseudomonas aeruginosa Deacetylase LpxC.
    J Med Chem. 2017;60:5002-5014.
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  9. LIN S, Koh JJ, Aung TT, Sin WLW, et al
    Semisynthetic Flavone-Derived Antimicrobials with Therapeutic Potential against Methicillin-Resistant Staphylococcus aureus (MRSA).
    J Med Chem. 2017 Jun 21. doi: 10.1021/acs.jmedchem.7b00380.
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  10. LIU F, Dawadi S, Maize KM, Dai R, et al
    Structure-Based Optimization of Pyridoxal 5'-Phosphate (PLP)-Dependent Transaminase Enzyme (BioA) Inhibitors that Target Biotin Biosynthesis in Mycobacterium tuberculosis.
    J Med Chem. 2017 Jun 8. doi: 10.1021/acs.jmedchem.7b00189.
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    May 2017
  11. PANCHAUD P, Bruyere T, Blumstein AC, Bur D, et al
    Discovery and Optimization of Isoquinoline Ethyl Ureas as Antibacterial Agents.
    J Med Chem. 2017;60:3755-3775.
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  12. BHOWMICK M, Tokmina-Roszyk D, Onwuha-Ekpete L, Harmon K, et al
    Second Generation Triple-Helical Peptide Inhibitors of Matrix Metalloproteinases.
    J Med Chem. 2017;60:3814-3827.
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  13. MAYER K, Eris D, Schwardt O, Sager CP, et al
    Urinary Tract Infection - Which Conformation of the Bacterial Lectin FimH Is Therapeutically Relevant?
    J Med Chem. 2017 May 4. doi: 10.1021/acs.jmedchem.7b00342.
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    April 2017
  14. HAGRAS M, Mohammad H, Mandour MS, Hegazy YA, et al
    Investigating the Antibacterial Activity of Biphenylthiazoles against Methicillin- and Vancomycin-Resistant Staphylococcus aureus (MRSA and VRSA).
    J Med Chem. 2017 Apr 24. doi: 10.1021/acs.jmedchem.7b00392.
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  15. SIRICILLA S, Mitachi K, Yang J, Eslamimehr S, et al
    A New Combination of a Pleuromutilin Derivative and Doxycycline for Treatment of Multidrug-Resistant Acinetobacter baumannii.
    J Med Chem. 2017;60:2869-2878.
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  16. YANG T, Moreira W, Nyantakyi SA, Chen H, et al
    Amphiphilic Indole Derivatives as Antimycobacterial Agents: Structure-Activity Relationships and Membrane Targeting Properties.
    J Med Chem. 2017;60:2745-2763.
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  17. TAN L, Tao Y, Wang T, Zou F, et al
    Discovery of Novel Pyridone-Conjugated Monosulfactams as Potent and Broad-Spectrum Antibiotics for Multidrug-Resistant Gram-Negative Infections.
    J Med Chem. 2017;60:2669-2684.
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    March 2017
  18. DENG Y, Sun C, Hunt DK, Fyfe C, et al
    Heterocyclyl Tetracyclines. 1. 7-Trifluoromethyl-8-Pyrrolidinyltetracyclines: Potent, Broad Spectrum Antibacterial Agents with Enhanced Activity against Pseudomonas aeruginosa.
    J Med Chem. 2017;60:2498-2512.
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  19. DOU X, Zhu X, Wang J, Dong N, et al
    Novel Design of Heptad Amphiphiles To Enhance Cell Selectivity, Salt Resistance, Antibiofilm Properties and Their Membrane-Disruptive Mechanism.
    J Med Chem. 2017;60:2257-2270.
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  20. HONG WD, Gibbons PD, Leung SC, Amewu R, et al
    Rational Design, Synthesis and Biological Evaluation of Heterocyclic Quinolones Targeting the respiratory chain of Mycobacterium tuberculosis.
    J Med Chem. 2017 Mar 17. doi: 10.1021/acs.jmedchem.6b01718.
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  21. MOHAMMAD H, Younis W, Chen L, Peters CE, et al
    Phenylthiazole Antibacterial Agents Targeting Cell Wall Synthesis Exhibit Potent Activity In Vitro and In Vivo against Vancomycin-resistant Enterococci.
    J Med Chem. 2017 Mar 1. doi: 10.1021/acs.jmedchem.6b01780.
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    February 2017
  22. TOLEDANO-MAGANA Y, Garcia-Ramos JC, Torres-Gutierrez C, Vazquez-Gasser C, et al
    Water-Soluble Ruthenium (II) Chiral Heteroleptic Complexes with Amoebicidal in Vitro and in Vivo Activity.
    J Med Chem. 2017;60:899-912.
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  23. ASTOLFI A, Felicetti T, Iraci N, Manfroni G, et al
    Pharmacophore-Based Repositioning of Approved Drugs as Novel Staphylococcus aureus NorA Efflux Pump Inhibitors.
    J Med Chem. 2017 Feb 8. doi: 10.1021/acs.jmedchem.6b01439.
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    December 2016
  24. STULAR T, Lesnik S, Rozman K, Schink J, et al
    Discovery of Mycobacterium tuberculosis InhA Inhibitors by Binding Sites Comparison and Ligands Prediction.
    J Med Chem. 2016.
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  25. GARZAN A, Willby MJ, Green KD, Gajadeera CS, et al
    Sulfonamide-Based Inhibitors of Aminoglycoside Acetyltransferase Eis Abolish Resistance to Kanamycin in Mycobacterium tuberculosis.
    J Med Chem. 2016;59:10619-10628.
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    September 2016
  26. GORDON CP, Olson SD, Lister JL, Kavanaugh JS, et al
    Truncated auto-inducing peptides as antagonists of Staphylococcus lugdunensis quorum sensing.
    J Med Chem. 2016.
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    July 2016
  27. BRUNNER K, Maric S, Reshma RS, Almqvist H, et al
    Inhibitors of the cysteine synthase CysM with antibacterial potency against dormant Mycobacterium tuberculosis.
    J Med Chem. 2016.
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    June 2016
  28. PITTA E, Rogacki MK, Balabon O, Huss S, et al
    Searching for new leads for Tuberculosis: Design, synthesis and biological evaluation of novel 2-quinolin-4-yloxyacetamides.
    J Med Chem. 2016.
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  29. BARANOWSKI C, Rubin EJ
    Could Killing Bacterial Subpopulations Hit Tuberculosis out of the Park?
    J Med Chem. 2016.
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  30. STEC J, Onajole OK, Lun S, Guo H, et al
    Indole-2-carboxamide-Based MmpL3 Inhibitors Show Exceptional Antitubercular Activity in an Animal Model of Tuberculosis Infection.
    J Med Chem. 2016.
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    May 2016
  31. YU M, Nagalingam G, Ellis S, Martinez E, et al
    Non-toxic metal-cyclam complexes, a new class of compounds with potency against drug-resistant Mycobacterium tuberculosis.
    J Med Chem. 2016.
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