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Articles published in
Proc Natl Acad Sci U S A
    September 2025
  1. MA E, Schafer CM, Xie J, Rudenko Y, et al
    Targeting endothelial ERG to mitigate vascular regression in retinopathies.
    Proc Natl Acad Sci U S A. 2025;122:e2507194122.
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  2. STANHOPE SC, Singhal K, Morato NM, Feng Y, et al
    Drosophila Ahcy is a redox sensor that modulates gene expression to protect against light stress-induced retinal degeneration.
    Proc Natl Acad Sci U S A. 2025;122:e2511388122.
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  3. WANG J, Zhou C, Zhuang K, Zou J, et al
    Sorting nexin 3 promotes ischemic retinopathy through RIP1- and RIP3-mediated myeloid cell necroptosis and mitochondrial fission.
    Proc Natl Acad Sci U S A. 2025;122:e2426578122.
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  4. GOMES C, Huang KC, Lavekar SS, Harkin J, et al
    Modeling human retinal ganglion cell axonal outgrowth, development, and pathology using pluripotent stem cell-based microfluidic platforms.
    Proc Natl Acad Sci U S A. 2025;122:e2423682122.
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  5. LIAO M, Ye Z, Zhao Y, Nan J, et al
    Single-cell transcriptome combined with genetic tracing reveals a roadmap of fibrosis formation during proliferative vitreoretinopathy.
    Proc Natl Acad Sci U S A. 2025;122:e2424487122.
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    August 2025
  6. HUANG Y, Lin H, Shi J, Chen Y, et al
    Serum metabolic patterns reveal the diagnostic and prognostic role of alanine abnormality in ocular adnexal lymphoma.
    Proc Natl Acad Sci U S A. 2025;122:e2506345122.
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    July 2025
  7. WANG Z, Anderson DMG, Messinger JD, Curcio CA, et al
    Glycolipids implicated as mediators of clinically visible retinal pigment epithelial migration in age-related macular degeneration.
    Proc Natl Acad Sci U S A. 2025;122:e2503191122.
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    June 2025
  8. TOOMEY CB, Pflugmacher S, Park K, Pihl J, et al
    Bruch's membrane heparan sulfate retains lipoproteins in the early stages of age-related macular degeneration.
    Proc Natl Acad Sci U S A. 2025;122:e2500727122.
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  9. WANG Y, Zhang YC, Ding ZQ, Xu SY, et al
    Feedback regulation between histone lactylation and ALKBH3-mediated glycolysis regulates age-related macular degeneration pathology.
    Proc Natl Acad Sci U S A. 2025;122:e2416046122.
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    May 2025
  10. MURPHY DP, Kolesnikov AV, Montana CL, Khaja ZM, et al
    Mechanisms of photoreceptor protection upon targeting the Nrl-Nr2e3 pathway.
    Proc Natl Acad Sci U S A. 2025;122:e2500446122.
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  11. JUN DJ, Schumacher MM, Jo Y, Faulkner RA, et al
    Allosteric regulation of UBIAD1 trafficking from ER to Golgi revealed by chemical genetic screening.
    Proc Natl Acad Sci U S A. 2025;122:e2426532122.
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  12. ZHANG J, Yang W, Wu J, Lin B, et al
    Understanding TAK1 deficiency in microglia: Dual mechanisms for photoreceptor protection in a mouse model of retinitis pigmentosa.
    Proc Natl Acad Sci U S A. 2025;122:e2423134122.
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  13. MARTIN M, Bolognesi B
    Massive mutagenesis reveals an incomplete amyloid motif in Bri2 that turns amyloidogenic upon C-terminal extension.
    Proc Natl Acad Sci U S A. 2025;122:e2415521122.
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    April 2025
  14. TWORAK A, Smidak R, Rodrigues Menezes C, Du SW, et al
    MFRP is a molecular hub that organizes the apical membrane of RPE cells by engaging in interactions with specific proteins and lipids.
    Proc Natl Acad Sci U S A. 2025;122:e2425523122.
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  15. CHANDLER LC, Gardner A, Cepko CL
    RPE-specific MCT2 expression promotes cone survival in models of retinitis pigmentosa.
    Proc Natl Acad Sci U S A. 2025;122:e2421978122.
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    March 2025
  16. COOPER ML, Gildea HK, Selles MC, Katafygiotou E, et al
    Astrocytes in the mouse brain respond bilaterally to unilateral retinal neurodegeneration.
    Proc Natl Acad Sci U S A. 2025;122:e2418249122.
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  17. DVORIANTCHIKOVA G, Moulin C, Fleishaker M, Almeida V, et al
    Genetic ablation of the TET family in retinal progenitor cells impairs photoreceptor development and leads to blindness.
    Proc Natl Acad Sci U S A. 2025;122:e2420091122.
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    February 2025
  18. VOLZ S, Malone JR, Guseman AJ, Gronenborn AM, et al
    Cataract-prone variants of gammaD-crystallin populate a conformation with a partially unfolded N-terminal domain under native conditions.
    Proc Natl Acad Sci U S A. 2025;122:e2410860122.
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    January 2025
  19. BISWAS N, Mori T, Ragava Chetty Nagaraj NK, Xin H, et al
    Adenosine diphosphate stimulates VEGF-independent choroidal endothelial cell proliferation: A potential escape from anti-VEGF therapy.
    Proc Natl Acad Sci U S A. 2025;122:e2418752122.
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  20. BUTENKO K, Neudorfer C, Dembek TA, Hollunder B, et al
    Engaging dystonia networks with subthalamic stimulation.
    Proc Natl Acad Sci U S A. 2025;122:e2417617122.
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    December 2024
  21. HATA M, Hata M, Dejda A, Pilon F, et al
    Corticosteroids reduce pathological angiogenesis yet compromise reparative vascular remodeling in a model of retinopathy.
    Proc Natl Acad Sci U S A. 2024;121:e2411640121.
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  22. HILDEBRANDT M, Kotewitsch M, Kaupp S, Salomon S, et al
    Stabilizing selection in an identified multisensory neuron in blind cavefish.
    Proc Natl Acad Sci U S A. 2024;121:e2415854121.
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  23. PATEL A, Pauzuolyte V, Ingham NJ, Leong YC, et al
    Rescue of cochlear vascular pathology prevents sensory hair cell loss in Norrie disease.
    Proc Natl Acad Sci U S A. 2024;121:e2322124121.
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    November 2024
  24. WEI Z, Hao C, Radeen KR, Hao Z, et al
    Deficiency in glutathione peroxidase 4 (GPX4) results in abnormal lens development and newborn cataract.
    Proc Natl Acad Sci U S A. 2024;121:e2407842121.
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  25. VEREERTBRUGGHEN A, Pizzano M, Cernutto A, Sabbione F, et al
    CD4(+) T cells drive corneal nerve damage but not epitheliopathy in an acute aqueous-deficient dry eye model.
    Proc Natl Acad Sci U S A. 2024;121:e2407648121.
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  26. DU SW, Newby GA, Salom D, Gao F, et al
    In vivo photoreceptor base editing ameliorates rhodopsin-E150K autosomal-recessive retinitis pigmentosa in mice.
    Proc Natl Acad Sci U S A. 2024;121:e2416827121.
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  27. SHARMA D, Lau E, Qin Y, Jee K, et al
    VEGF inhibition increases expression of HIF-regulated angiogenic genes by the RPE limiting the response of wet AMD eyes to aflibercept.
    Proc Natl Acad Sci U S A. 2024;121:e2322759121.
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    October 2024
  28. CHANG D, Caterina MJ
    Pinning down a perpetrator in postsurgical eye pain.
    Proc Natl Acad Sci U S A. 2024;121:e2417221121.
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  29. PATHAK V, Bertelli PM, Pedrini E, Harkin K, et al
    Modulation of diabetes-related retinal pathophysiology by PTX3.
    Proc Natl Acad Sci U S A. 2024;121:e2320034121.
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    September 2024
  30. LI W, He S, Tan J, Li N, et al
    Transcription factor EGR2 alleviates autoimmune uveitis via activation of GDF15 to modulate the retinal microglial phenotype.
    Proc Natl Acad Sci U S A. 2024;121:e2316161121.
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  31. LIU Y, Wang A, Chen C, Zhang Q, et al
    Microglial cGAS-STING signaling underlies glaucoma pathogenesis.
    Proc Natl Acad Sci U S A. 2024;121:e2409493121.
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    August 2024
  32. AMARAL L, Thomas P, Amedi A, Striem-Amit E, et al
    Longitudinal stability of individual brain plasticity patterns in blindness.
    Proc Natl Acad Sci U S A. 2024;121:e2320251121.
    >> Share

    July 2024
  33. BORKAR S, Baumli P, Vance T, Sharma E, et al
    Elucidating the roles of electrolytes and hydrogen bonding in the dewetting dynamics of the tear film.
    Proc Natl Acad Sci U S A. 2024;121:e2407501121.
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    June 2024
  34. CHEN M, Wang Y, Dalal R, Du J, et al
    Alternative oxidase blunts pseudohypoxia and photoreceptor degeneration due to RPE mitochondrial dysfunction.
    Proc Natl Acad Sci U S A. 2024;121:e2402384121.
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    May 2024
  35. GOTO S, Tsutsumi A, Lee Y, Hosojima M, et al
    Cryo-EM structures elucidate the multiligand receptor nature of megalin.
    Proc Natl Acad Sci U S A. 2024;121:e2318859121.
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  36. FAIN GL
    The mechanism of genetically inherited night blindness.
    Proc Natl Acad Sci U S A. 2024;121:e2408254121.
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  37. CHAI Z, Ye Y, Silverman D, Rose K, et al
    Dark continuous noise from mutant G90D-rhodopsin predominantly underlies congenital stationary night blindness.
    Proc Natl Acad Sci U S A. 2024;121:e2404763121.
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    April 2024
  38. LIU Y, Liu X, Chen X, Yang Z, et al
    Senolytic and senomorphic agent procyanidin C1 alleviates structural and functional decline in the aged retina.
    Proc Natl Acad Sci U S A. 2024;121:e2311028121.
    >> Share

    March 2024
  39. KOLESNIKOV AV, Murphy DP, Corbo JC, Kefalov VJ, et al
    Germline knockout of Nr2e3 protects photoreceptors in three distinct mouse models of retinal degeneration.
    Proc Natl Acad Sci U S A. 2024;121:e2316118121.
    >> Share

  40. KOJIMA Y, Ito RK, Fukuyama I, Ohkubo Y, et al
    Foraging predicts the evolution of warning coloration and mimicry in snakes.
    Proc Natl Acad Sci U S A. 2024;121:e2318857121.
    >> Share


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