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Epilepsy
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Articles published in
Brain
    September 2025
  1. SUNDMAN AK, Jin S, Vadlamudi L, King GF, et al
    The molecular basis of KCNH1-related epileptic encephalopathy and the challenge of developing targeted therapeutics.
    Brain. 2025 Sep 23:awaf353. doi: 10.1093.
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  2. AITKEN F, Winston JS, O'Muircheartaigh J, Carmichael DW, et al
    The potential of laminar functional MRI in refining the understanding of epilepsy in humans.
    Brain. 2025 Sep 3:awaf320. doi: 10.1093.
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  3. COCKLE E, Malpas CB, Coleman H, McIlroy A, et al
    Cortical stimulation predicts language decline following SEEG radiofrequency thermocoagulation.
    Brain. 2025;148:3314-3324.
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    August 2025
  4. QUIROZ V, Alecu JE, Zubair U, Bernardi K, et al
    Molecular and clinical spectrum of epilepsy-dyskinesia syndromes: a cross-sectional study of 609 patients.
    Brain. 2025 Aug 14:awaf297. doi: 10.1093.
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  5. NGO A, Liu L, Lariviere S, Kebets V, et al
    Associations between epilepsy-related polygenic risk and brain morphology in childhood.
    Brain. 2025 Aug 14:awaf259. doi: 10.1093.
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  6. Correction to: Heterozygous variants in USP25 cause genetic generalized epilepsy.
    Brain. 2025 Aug 6:awaf287. doi: 10.1093.
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  7. MELI N, Sheran K, Pitsch J, Krabbe S, et al
    Alterations in dopaminergic innervation and receptors in focal cortical dysplasia.
    Brain. 2025;148:2899-2911.
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    July 2025
  8. ENGLOT DJ, Jehi L
    ILAE position on early surgery for drug sensitive lesional focal epilepsy.
    Brain. 2025 Jul 18:awaf266. doi: 10.1093.
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  9. BENNINGER F, Goldberg I
    Beyond resistance: early surgery for focal epilepsy.
    Brain. 2025 Jul 3:awaf250. doi: 10.1093.
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    June 2025
  10. DANG YL, Esnault K, Fitt G, O'Brien TJ, et al
    Twins with temporal lobe epilepsy: genetic contributions to hippocampal sclerosis and other subtypes.
    Brain. 2025 Jun 18:awaf209. doi: 10.1093.
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  11. SEN A
    Disentangling epilepsy and dementia: more to do, together.
    Brain. 2025 Jun 10:awaf225. doi: 10.1093.
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  12. HIRANO Y, Miyazaki Y, Ishikawa D, Inahashi H, et al
    Biallelic LGI1 and ADAM23 variants cause hippocampal epileptic encephalopathy via the LGI1-ADAM22/23 pathway.
    Brain. 2025 Jun 2:awaf202. doi: 10.1093.
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    May 2025
  13. DIMAKOPOULOS V, Gotman J, Klimes P, von Ellenrieder N, et al
    Multicentre analysis of seizure outcome predicted by removal of high-frequency oscillations.
    Brain. 2025;148:1769-1777.
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    April 2025
  14. YAM M, Nassir J, Galber D, Quinn S, et al
    A mouse model of GRIN2D developmental and epileptic encephalopathy recapitulates the human disease.
    Brain. 2025 Apr 25:awaf149. doi: 10.1093.
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  15. TEOH J, Simko J, Camp CR, Liu CJ, et al
    Synaptic dysregulation in a mouse model of GRIN2D developmental and epileptic encephalopathy.
    Brain. 2025 Apr 9:awaf125. doi: 10.1093.
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    March 2025
  16. CHENG Y, Wang D, Zhang X, Jin G, et al
    Structural network-specific effect of extreme capsule stimulation for drug-resistant focal epilepsy.
    Brain. 2025 Mar 21:awaf097. doi: 10.1093.
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  17. THIO BJ, Sinha N, Davis KA, Sinha SR, et al
    Stereo-EEG propagating source reconstruction identifies new surgical targets for epilepsy patients.
    Brain. 2025;148:764-775.
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  18. MITO R, Cole J, Genc S, Jackson G, et al
    Towards precision MRI biomarkers in epilepsy with normative modelling.
    Brain. 2025 Mar 5:awaf090. doi: 10.1093.
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    February 2025

  19. Correction to: Threshold of somatic mosaicism leading to brain dysfunction with focal epilepsy.
    Brain. 2025 Feb 11:awaf041. doi: 10.1093.
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  20. CHIANG S, Khambhati AN, Tcheng TK, Loftman AP, et al
    State-dependent effects of responsive neurostimulation depend on seizure localization.
    Brain. 2025;148:521-532.
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    January 2025
  21. SAINBURG LE, Englot DJ, Morgan VL
    The impact of resective epilepsy surgery on the brain network: evidence from post-surgical imaging.
    Brain. 2025 Jan 24:awaf026. doi: 10.1093.
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  22. GLEICHGERRCHT E, Kaestner E, Hassanzadeh R, Roth RW, et al
    Redefining diagnostic lesional status in temporal lobe epilepsy with artificial intelligence.
    Brain. 2025 Jan 22:awaf020. doi: 10.1093.
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  23. TAI XY, Galovic M
    Late-onset epilepsy and neurodegeneration: intersecting mechanisms or separate entities?
    Brain. 2025;148:6-8.
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  24. OERLEMANS J, Alejandro RJ, Van Roost D, Boon P, et al
    Unravelling the origin of reward positivity: a human intracranial event-related brain potential study.
    Brain. 2025;148:199-211.
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  25. BERECKI G, Tao E, Howell KB, Coorg RK, et al
    Nav1.2 channel mutations preventing fast inactivation lead to SCN2A encephalopathy.
    Brain. 2025;148:212-226.
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  26. TREVELYAN AJ, Marks VS, Graham RT, Denison T, et al
    On brain stimulation in epilepsy.
    Brain. 2025 Jan 2:awae385. doi: 10.1093.
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    December 2024
  27. JACKSON HD, Cotler MJ, Saunders GW, Cornelssen CA, et al
    Intracerebral delivery of antiseizure medications by microinvasive neural implants.
    Brain. 2024;147:4147-4156.
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  28. WILSON W, Tehrani N, Pittman DJ, Dykens P, et al
    Mapping interictal discharges using intracranial EEG-fMRI to predict postsurgical outcomes.
    Brain. 2024;147:4157-4168.
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    October 2024
  29. MHANNA A, Bruss J, Griffis JC, Sullivan AW, et al
    Lesion and lesion network localization of dysnomia after epilepsy surgery.
    Brain. 2024 Oct 18:awae322. doi: 10.1093.
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  30. MAGIELSKI JH, Ruggiero SM, Xian J, Parthasarathy S, et al
    The clinical and genetic spectrum of paediatric speech and language disorders.
    Brain. 2024 Oct 16:awae264. doi: 10.1093.
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  31. AZEEM A, Abdallah C, von Ellenrieder N, El Kosseifi C, et al
    Explaining slow seizure propagation with white matter tractography.
    Brain. 2024;147:3458-3470.
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    September 2024
  32. BOLLING-LADEGAARD E, Dreier JW, Christensen J
    An algorithm for drug-resistant epilepsy in Danish national registers.
    Brain. 2024 Sep 10:awae286. doi: 10.1093.
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    August 2024
  33. BERG AT, Thompson CH, Myers LS, Anderson E, et al
    Expanded clinical phenotype spectrum correlates with variant function in SCN2A-related disorders.
    Brain. 2024;147:2761-2774.
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    July 2024
  34. LAGARDE S, Bartolomei F
    Sink into the epileptogenic zone: findings from directed SEEG functional connectivity decomposition.
    Brain. 2024 Jul 29:awae256. doi: 10.1093.
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  35. CABALO DG, DeKraker J, Royer J, Xie K, et al
    Differential reorganization of episodic and semantic memory systems in epilepsy-related mesiotemporal pathology.
    Brain. 2024 Jul 26:awae197. doi: 10.1093.
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  36. MINERE M, Mortensen M, Dorovykh V, Warnes G, et al
    Presynaptic hyperexcitability reversed by positive allosteric modulation of a GABABR epilepsy variant.
    Brain. 2024 Jul 19:awae232. doi: 10.1093.
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  37. DEVULDER A, Vanderlinden G, Van Langenhoven L, Testelmans D, et al
    Epileptic activity on foramen ovale electrodes is associated with sleep and tau pathology in Alzheimer's disease.
    Brain. 2024 Jul 11:awae231. doi: 10.1093.
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  38. LARIVIERE S, Park BY, Royer J, DeKraker J, et al
    Connectome reorganization associated with temporal lobe pathology and its surgical resection.
    Brain. 2024;147:2483-2495.
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    June 2024
  39. KIM J, Park SM, Koh HY, Ko A, et al
    Threshold of somatic mosaicism leading to brain dysfunction with focal epilepsy.
    Brain. 2024 Jun 25:awae190. doi: 10.1093.
    >> Share

  40. BALLERINI A, Biagioli N, Carbone C, Chiari A, et al
    Late-onset temporal lobe epilepsy: insights from brain atrophy and Alzheimer's disease biomarkers.
    Brain. 2024 Jun 25:awae207. doi: 10.1093.
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  41. FAN CX, Liu XR, Mei DQ, Li BM, et al
    Heterozygous variants in USP25 cause genetic generalized epilepsy.
    Brain. 2024 Jun 14:awae191. doi: 10.1093.
    >> Share

  42. DOSS DJ, Shless JS, Bick SK, Makhoul GS, et al
    The interictal suppression hypothesis is the dominant differentiator of seizure onset zones in focal epilepsy.
    Brain. 2024 Jun 14:awae189. doi: 10.1093.
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    May 2024
  43. SAINBURG LE, Morgan VL
    Investigation of network reorganization after epilepsy surgery is worth the effort.
    Brain. 2024 May 30:awae172. doi: 10.1093.
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  44. WEISS SA, Sperling MR, Engel J Jr, Staba R, et al
    To plan efficacious epilepsy surgery.
    Brain. 2024 May 17:awae162. doi: 10.1093.
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  45. ROEHRI N, Vulliemoz S, Lagarde S
    The challenge of assessing invasive biomarkers for epilepsy surgery.
    Brain. 2024 May 16:awae164. doi: 10.1093.
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  46. SHI W, Eden U, Kramer MA, Chu CJ, et al
    Reply: The challenge of assessing invasive biomarkers for epilepsy surgery and To plan efficacious epilepsy surgery.
    Brain. 2024 May 16:awae165. doi: 10.1093.
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    April 2024
  47. UPADHYA M, Kirmann T, Wilson MA, Simon CM, et al
    Peripherally-derived LGI1-reactive monoclonal antibodies cause epileptic seizures in vivo.
    Brain. 2024 Apr 25:awae129. doi: 10.1093.
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  48. MBIZVO GK, Bucci T, Lip GYH, Marson AG, et al
    Morbidity and mortality risks associated with valproate withdrawal in young men and women with epilepsy.
    Brain. 2024 Apr 24:awae128. doi: 10.1093.
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  49. WODEYAR A, Chinappen D, Mylonas D, Baxter B, et al
    Thalamic epileptic spikes disrupt sleep spindles in patients with epileptic encephalopathy.
    Brain. 2024 Apr 23:awae119. doi: 10.1093.
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  50. ERIKSSON MH, Prentice F, Piper RJ, Wagstyl K, et al
    Long-term neuropsychological trajectories in children with epilepsy: does surgery halt decline?
    Brain. 2024 Apr 20:awae121. doi: 10.1093.
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  51. DI BERARDINO C, Mainardi M, Brusco S, Benvenuto E, et al
    Reply: Spatial and temporal manipulation of the Scn1a gene affect adult brain function.
    Brain. 2024;147:e31-e33.
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  52. JANSEN NA, van den Maagdenberg AMJM
    Spatial and temporal manipulation of the Scn1a gene affect adult brain function.
    Brain. 2024;147:e29-e30.
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  53. SPARBER P, Sharova M, Davydenko K, Pyankov D, et al
    Deciphering the impact of coding and non-coding SCN1A gene variants on RNA splicing.
    Brain. 2024;147:1278-1293.
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  54. MACDONALD-LAURS E, Warren AEL, Francis P, Mandelstam SA, et al
    The clinical, imaging, pathological and genetic landscape of bottom-of-sulcus dysplasia.
    Brain. 2024;147:1264-1277.
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  55. DI BERARDINO C, Mainardi M, Brusco S, Benvenuto E, et al
    Temporal manipulation of the Scn1a gene reveals its essential role in adult brain function.
    Brain. 2024;147:1216-1230.
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  56. YUAN Y, Lopez-Santiago L, Denomme N, Chen C, et al
    Antisense oligonucleotides restore excitability, GABA signalling and sodium current density in a Dravet syndrome model.
    Brain. 2024;147:1231-1246.
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    March 2024
  57. SHIMODA Y, Leite M, Graham RT, Marvin JS, et al
    Extracellular glutamate and GABA transients at the transition from interictal spiking to seizures.
    Brain. 2024;147:1011-1024.
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  58. VERMOYAL JC, Hardy D, Goirand-Lopez L, Vinck A, et al
    Grey matter heterotopia subtypes show specific morpho-electric signatures and network dynamics.
    Brain. 2024;147:996-1010.
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    February 2024
  59. SHI W, Shaw D, Walsh KG, Han X, et al
    Spike ripples localize the epileptogenic zone best: an international intracranial study.
    Brain. 2024 Feb 7:awae037. doi: 10.1093.
    >> Share

  60. ALMACELLAS BARBANOJ A, Graham RT, Maffei B, Carpenter JC, et al
    Anti-seizure gene therapy for focal cortical dysplasia.
    Brain. 2024;147:542-553.
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  61. PASCHEN E, Kleis P, Vieira DM, Heining K, et al
    On-demand low-frequency stimulation for seizure control: efficacy and behavioural implications.
    Brain. 2024;147:505-520.
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    January 2024
  62. ALMOUSA H, Lewis SA, Bakhtiari S, Nordlie SH, et al
    TRAPPC6B biallelic variants cause a neurodevelopmental disorder with TRAPP II and trafficking disruptions.
    Brain. 2024;147:311-324.
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  63. LIN SXN, Ahring PK, Keramidas A, Liao VWY, et al
    Correlations of receptor desensitization of gain-of-function GABRB3 variants with clinical severity.
    Brain. 2024;147:224-239.
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    December 2023
  64. DREIER JW, Trabjerg BB, Plana-Ripoll O, Skipper N, et al
    Epilepsy in childhood and school performance: a nation-wide cohort study.
    Brain. 2023 Dec 16:awad382. doi: 10.1093.
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  65. XIAN J, Thalwitzer KM, McKee J, Sullivan KR, et al
    Delineating clinical and developmental outcomes in STXBP1-related disorders.
    Brain. 2023;146:5182-5197.
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  66. AGOPYAN-MIU AH, Merricks EM, Smith EH, McKhann GM 2nd, et al
    Cell-type specific and multiscale dynamics of human focal seizures in limbic structures.
    Brain. 2023;146:5209-5223.
    >> Share

  67. WITHERS CP, Diamond JM, Yang B, Snyder K, et al
    Identifying sources of human interictal discharges with travelling wave and white matter propagation.
    Brain. 2023;146:5168-5181.
    >> Share

  68. VAN HUGTE EJH, Lewerissa EI, Wu KM, Scheefhals N, et al
    SCN1A-deficient excitatory neuronal networks display mutation-specific phenotypes.
    Brain. 2023;146:5153-5167.
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    October 2023
  69. SURYAVANSHI P, Sawant-Pokam P, Clair S, Brennan KC, et al
    Increased presynaptic excitability in a migraine with aura mutation.
    Brain. 2023 Oct 13:awad326. doi: 10.1093.
    >> Share

  70. KAESTNER E, Reyes A
    Out of one, how many? Subtyping in epilepsy.
    Brain. 2023 Oct 12:awad354. doi: 10.1093.
    >> Share

  71. XIAO F, Caciagli L, Wandschneider B, Sone D, et al
    Identification of different MRI atrophy progression trajectories in epilepsy by subtype and stage inference.
    Brain. 2023 Oct 9:awad284. doi: 10.1093.
    >> Share

  72. ANDERSON DN, Charlebois CM, Smith EH, Davis TS, et al
    Closed-loop stimulation in periods with less epileptiform activity drives improved epilepsy outcomes.
    Brain. 2023 Oct 5:awad343. doi: 10.1093.
    >> Share

  73. CAMPOS-RODRIGUEZ C, Palmer D, Forcelli PA
    Optogenetic stimulation of the superior colliculus suppresses genetic absence seizures.
    Brain. 2023;146:4320-4335.
    >> Share

    September 2023
  74. MARTINS CUSTODIO H, Clayton LM, Bellampalli R, Pagni S, et al
    Widespread genomic influences on phenotype in Dravet syndrome, a 'monogenic' condition.
    Brain. 2023;146:3885-3897.
    >> Share

    July 2023
  75. MAROOFIAN R, Kaiyrzhanov R, Cali E, Zamani M, et al
    Biallelic MED27 variants lead to variable ponto-cerebello-lental degeneration with movement disorders.
    Brain. 2023 Jul 30:awad257. doi: 10.1093.
    >> Share


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