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Articles published in
Proc Natl Acad Sci U S A
    November 2025

  1. Correction for Hao et al., Synthetical lethality of Werner helicase and mismatch repair deficiency is mediated by p53 and PUMA in colon cancer.
    Proc Natl Acad Sci U S A. 2025;122:e2529649122.
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  2. WANG X, Cramer Z, Leu NA, Monaghan K, et al
    Forward genetic screening in engineered colorectal cancer organoids identifies regulators of metastasis.
    Proc Natl Acad Sci U S A. 2025;122:e2510910122.
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    June 2025
  3. DELANNE-CUMENAL M, Defaye M, Delanne-Cumenal A, Ahmed M, et al
    Neuronal ALKAL2 and its ALK receptor contribute to the development of colitis-associated colorectal cancer.
    Proc Natl Acad Sci U S A. 2025;122:e2500632122.
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  4. IGUCHI E, Takai A, Oe N, Fujii Y, et al
    Epithelial Regnase-1 inhibits colorectal tumor growth by regulating IL-17 signaling via degradation of NFKBIZ mRNA.
    Proc Natl Acad Sci U S A. 2025;122:e2500820122.
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    May 2025
  5. ZHANG Y, Zuo A, Ba Y, Liu S, et al
    Cancer-associated fibroblast-derived SEMA3C facilitates colorectal cancer liver metastasis via NRP2-mediated MAPK activation.
    Proc Natl Acad Sci U S A. 2025;122:e2423077122.
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  6. JAUREGI-MIGUEL A, Soderholm S, Weiss T, Nordin A, et al
    The developmental factor TBX3 engages with the Wnt/beta-catenin transcriptional complex in colorectal cancer to regulate metastasis genes.
    Proc Natl Acad Sci U S A. 2025;122:e2419691122.
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    April 2025
  7. XI X, Liu L, Tuano N, Tailhades J, et al
    SRP19 and the protein secretion machinery is a targetable vulnerability in cancers with APC loss.
    Proc Natl Acad Sci U S A. 2025;122:e2409677122.
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  8. HUANG C, Wang L, Zhuo C, Chen W, et al
    ID3 enhances PD-L1 expression by restructuring MYC to promote colorectal cancer immune evasion.
    Proc Natl Acad Sci U S A. 2025;122:e2423490122.
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  9. MARONGIU GL, Fink U, Schopf F, Oder A, et al
    Structural basis for immune cell binding of Fusobacterium nucleatum via the trimeric autotransporter adhesin CbpF.
    Proc Natl Acad Sci U S A. 2025;122:e2418155122.
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    March 2025
  10. JIN J, Zhang R, Li J, Gao F, et al
    The NAE1-mediated neddylation operates as an essential post-translational modification checkpoint for effector CD8(+) T cells.
    Proc Natl Acad Sci U S A. 2025;122:e2424061122.
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    November 2024
  11. DONG X, Sun F, Secaira-Morocho H, Hui A, et al
    The dichotomous roles of microbial-modified bile acids 7-oxo-DCA and isoDCA in intestinal tumorigenesis.
    Proc Natl Acad Sci U S A. 2024;121:e2317596121.
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  12. LI M, Chen X, Qu P, Shao Z, et al
    FBXO22 inhibits colitis and colorectal carcinogenesis by regulating the degradation of the S2448-phosphorylated form of mTOR.
    Proc Natl Acad Sci U S A. 2024;121:e2402035121.
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    October 2024
  13. ZHU Q, Li J, Sun H, Fan Z, et al
    O-GlcNAcylation of enolase 1 serves as a dual regulator of aerobic glycolysis and immune evasion in colorectal cancer.
    Proc Natl Acad Sci U S A. 2024;121:e2408354121.
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  14. ABDULLAYEVA G, Liu H, Liu TC, Simmons A, et al
    Goblet cell differentiation subgroups in colorectal cancer.
    Proc Natl Acad Sci U S A. 2024;121:e2414213121.
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  15. YE WL, Huang L, Yang XQ, Wan S, et al
    TRIM21 induces selective autophagic degradation of c-Myc and sensitizes regorafenib therapy in colorectal cancer.
    Proc Natl Acad Sci U S A. 2024;121:e2406936121.
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  16. FAN L, Liu B, Wang Y, Tang B, et al
    Intestinal Lactobacillus murinus-derived small RNAs target porcine polyamine metabolism.
    Proc Natl Acad Sci U S A. 2024;121:e2413241121.
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    September 2024
  17. ZHANG N, Zhang R, Jiang L, Gao Z, et al
    Inhibition of colorectal cancer in Alzheimer's disease is mediated by gut microbiota via induction of inflammatory tolerance.
    Proc Natl Acad Sci U S A. 2024;121:e2314337121.
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    August 2024
  18. ZINK A, Obermeyer Z, Pierson E
    Race adjustments in clinical algorithms can help correct for racial disparities in data quality.
    Proc Natl Acad Sci U S A. 2024;121:e2402267121.
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    July 2024
  19. BORTEL P, Hagn G, Skos L, Bileck A, et al
    Memory effects of prior subculture may impact the quality of multiomic perturbation profiles.
    Proc Natl Acad Sci U S A. 2024;121:e2313851121.
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    June 2024
  20. HUANG KB, Wang FY, Lu Y, Yang LM, et al
    Cu(II) complex that synergistically potentiates cytotoxicity and an antitumor immune response by targeting cellular redox homeostasis.
    Proc Natl Acad Sci U S A. 2024;121:e2404668121.
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    May 2024
  21. YANG C, Dong X, Sun B, Cao T, et al
    Physical immune escape: Weakened mechanical communication leads to escape of metastatic colorectal carcinoma cells from macrophages.
    Proc Natl Acad Sci U S A. 2024;121:e2322479121.
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    March 2024
  22. MICHL J, White B, Monterisi S, Bodmer WF, et al
    Phenotypic screen of sixty-eight colorectal cancer cell lines identifies CEACAM6 and CEACAM5 as markers of acid resistance.
    Proc Natl Acad Sci U S A. 2024;121:e2319055121.
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  23. BONNET V, Maikranz E, Madec M, Vertti-Quintero N, et al
    Cancer-on-a-chip model shows that the adenomatous polyposis coli mutation impairs T cell engagement and killing of cancer spheroids.
    Proc Natl Acad Sci U S A. 2024;121:e2316500121.
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