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Articles published in
Clin Cancer Res
    October 2017
  1. GROTHEY A, Strosberg JR, Renfro LA, Hurwitz HI, et al
    A Randomized, Double-blind, Placebo-controlled Phase 2 Study of Ontuxizumab (MORAb-004) in Patients with Chemorefractory Metastatic Colorectal Cancer.
    Clin Cancer Res. 2017 Oct 30. pii: clincanres.1558.2017.
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  2. LAL N, White BS, Goussous G, Pickles OJ, et al
    KRAS mutation and Consensus Molecular Subtypes 2 and 3 are independently associated with reduced immune infiltration and reactivity in colorectal cancer.
    Clin Cancer Res. 2017 Oct 23. pii: clincanres.1090.2017.
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  3. BOCCACCIO C, Luraghi P, Bigatto V, Cipriano E, et al
    A molecularly annotated model of patient-derived colon cancer stem-like cells to assess genetic and non-genetic mechanisms of resistance to anti-EGFR therapy.
    Clin Cancer Res. 2017 Oct 3. pii: clincanres.2151.2017.
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    September 2017
  4. KANG DW, Lee BH, Suh YA, Choi YS, et al
    Phospholipase D1 inhibition linked to upregulation of ICAT blocks colorectal cancer growth hyperactivated by Wnt/beta-catenin and PI3K/Akt Signaling.
    Clin Cancer Res. 2017 Sep 22. pii: clincanres.0749.2017.
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  5. JOUNG JG, Oh BY, Hong HK, AlKhalidi H, et al
    Tumor heterogeneity predicts metastatic potential in colorectal cancer.
    Clin Cancer Res. 2017 Sep 22. pii: clincanres.0306.2017.
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  6. YIN Y, Yao S, Hu Y, Feng Y, et al
    The Immune-microenvironment Confers Chemoresistance of Colorectal Cancer through Macrophage-derived IL-6.
    Clin Cancer Res. 2017 Sep 19. pii: clincanres.1283.2017.
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  7. BARTOLOME RA, Aizpurua C, Jaen M, Torres S, et al
    Monoclonal antibodies directed against cadherin RGD exhibit therapeutic activity against melanoma and colorectal cancer metastasis.
    Clin Cancer Res. 2017 Sep 15. pii: clincanres.1444.2017.
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  8. JIAO HL, Ye YP, Yang RW, Sun HY, et al
    Down-regulation of SAFB sustains the NF-kappaB pathway by targeting TAK1 during the progression of colorectal cancer.
    Clin Cancer Res. 2017 Sep 14. pii: clincanres.0747.2017.
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    August 2017
  9. SCURR MJ, Pembroke T, Bloom A, Roberts DJ, et al
    Low-dose cyclophosphamide induces anti-tumor T-cell responses which associate with survival in metastatic colorectal cancer.
    Clin Cancer Res. 2017 Aug 29. pii: clincanres.0895.2017.
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    June 2017
  10. YAO YM, Donoho GP, Iversen P, Zhang Y, et al
    Mouse PDX Trial Suggests Synergy of concurrent Inhibition of RAF and EGFR in Colorectal Cancer with BRAF or KRAS mutations.
    Clin Cancer Res. 2017 Jun 13. pii: clincanres.3250.2016.
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  11. PEKOW J, Meckel K, Dougherty U, Huang Y, et al
    miR-193a-3p is a key tumor suppressor in ulcerative colitis-associated colon cancer and promotes carcinogenesis through up-regulation of IL17RD.
    Clin Cancer Res. 2017 Jun 9. pii: clincanres.0171.2017.
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  12. SCHOLER LV, Reinert T, Orntoft MW, Kassentoft CG, et al
    Clinical implications of monitoring circulating tumor DNA in patients with colorectal cancer.
    Clin Cancer Res. 2017 Jun 9. pii: clincanres.0510.2017.
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  13. PRIEUR A, Cappellini M, Habif G, Lefranc MP, et al
    Targeting the Wnt pathway and cancer stem cells with anti-progastrin humanized antibodies: a major breakthrough for K-RAS mutated colorectal cancer treatment.
    Clin Cancer Res. 2017 Jun 9. pii: clincanres.0533.2017.
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  14. GARLAN F, Laurent-Puig P, Sefrioui D, Siauve N, et al
    Early evaluation of circulating tumor DNA as marker of therapeutic efficacy in metastatic colorectal cancer patients (PLACOL study).
    Clin Cancer Res. 2017 Jun 2. pii: clincanres.3155.2016.
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    May 2017
  15. STIEGELBAUER V, Vychytilova-Faltejskova P, Karbiener M, Pehserl AM, et al
    MicroRNA-196b-5p regulates colorectal cancer cell migration and metastases through interaction of HOXB7 and GALNT5.
    Clin Cancer Res. 2017 May 22. pii: clincanres.0023.2017.
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  16. GOLDSTEIN JB, Wu W, Borras E, Masand G, et al
    Can Microsatellite Status of Colorectal Cancer be Reliably Assessed after Neoadjuvant Therapy?
    Clin Cancer Res. 2017 May 18. pii: clincanres.2994.2016.
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    April 2017
  17. XU JM, Wang Y, Wang YL, Wang Y, et al
    PIK3CA mutations contribute to acquired cetuximab resistance in metastatic colorectal cancer patients.
    Clin Cancer Res. 2017 Apr 19. pii: clincanres.2738.2016.
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  18. THIERRY AR, Pastor B, Jiang ZQ, Katsiampoura A, et al
    Circulating DNA demonstrates convergent evolution and common resistance mechanisms during treatment of colorectal cancer.
    Clin Cancer Res. 2017 Apr 11. pii: clincanres.0232.2017.
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    March 2017
  19. CARBONE C, Piro G, Simionato F, Ligorio F, et al
    Homeobox B9 mediates resistance to anti-VEGF therapy in colorectal cancer patients.
    Clin Cancer Res. 2017 Mar 15. pii: clincanres.3153.2016.
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  20. PARSEGHIAN C, Parikh NU, Wu JY, Jiang ZQ, et al
    Dual Inhibition of EGFR and c-Src by Cetuximab and Dasatinib Combined with FOLFOX Chemotherapy in Patients with Metastatic Colorectal Cancer.
    Clin Cancer Res. 2017 Mar 9. pii: clincanres.3138.2016.
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    February 2017
  21. WENG W, Wei Q, Toden S, Yoshida K, et al
    Circular RNA ciRS-7 - A promising prognostic biomarker and a potential therapeutic target in colorectal cancer.
    Clin Cancer Res. 2017 Feb 7. pii: clincanres.2541.2016.
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    January 2017
  22. GOVERNA V, Trella E, Mele V, Tornillo L, et al
    The interplay between neutrophils and CD8+ T cells improves survival in human colorectal cancer.
    Clin Cancer Res. 2017 Jan 20. pii: clincanres.2047.2016.
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    November 2016
  23. BLAJ C, Bringmann A, Schmidt EM, Urbischek M, et al
    ADNP is a therapeutically inducible repressor of WNT signaling in colorectal cancer.
    Clin Cancer Res. 2016 Nov 30. pii: clincanres.1604.2016.
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  24. SUMMERS M, Smith CG, Maughan TS, Kaplan R, et al
    BRAF and NRAS locus specific variants have different outcomes on survival to colorectal cancer.
    Clin Cancer Res. 2016 Nov 4. pii: clincanres.1541.2016.
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    October 2016
  25. PIETRANTONIO F, Vernieri C, Siravegna G, Mennitto A, et al
    Heterogeneity of acquired resistance to anti-EGFR monoclonal antibodies in patients with metastatic colorectal cancer.
    Clin Cancer Res. 2016 Oct 25. pii: clincanres.1863.2016.
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  26. LIANG JQ, Chiu J, Chen Y, Huang Y, et al
    Fecal Bacteria Act as Novel Biomarkers for Non-Invasive Diagnosis of Colorectal Cancer.
    Clin Cancer Res. 2016 Oct 3. pii: clincanres.1599.2016.
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  27. NEGRI FV, Boggiani D, Rimanti A, Musolino A, et al
    FCGR, Cetuximab, and Colorectal Cancer Survival-Letter.
    Clin Cancer Res. 2016;22:4958.
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    September 2016
  28. MA Y, Wang L, Neitzel LR, Loganathan S, et al
    The MAPK pathway regulates intrinsic resistance to BET inhibitors in colorectal cancer.
    Clin Cancer Res. 2016 Sep 27. pii: clincanres.0453.2016.
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  29. PARK JH, Van Wyk HC, McMillan DC, Quinn JA, et al
    Signal transduction and activator of transcription-3 (STAT3) in patients with colorectal cancer: associations with the phenotypic features of the tumour and host.
    Clin Cancer Res. 2016 Sep 27. pii: clincanres.1416.2016.
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  30. SALVUCCI M, Wurstle ML, Morgan C, Curry S, et al
    A stepwise integrated approach to personalized risk predictions in stage III colorectal cancer.
    Clin Cancer Res. 2016 Sep 20. pii: clincanres.1084.2016.
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    August 2016
  31. SHIGEYASU K, Okugawa Y, Toden S, Boland CR, et al
    Exportin-5 functions as an oncogene and a potential therapeutic target in colorectal cancer.
    Clin Cancer Res. 2016 Aug 23. pii: clincanres.1023.2016.
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  32. WEI TT, Lin YT, Tseng RY, Shun CT, et al
    Prevention of Colitis and Colitis-Associated Colorectal Cancer by a Novel Polypharmacological Histone Deacetylase Inhibitor.
    Clin Cancer Res. 2016;22:4158-69.
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  33. TOFFOLI G, Sharma MR, Marangon E, Posocco B, et al
    Genotype-guided dosing study of FOLFIRI plus bevacizumab in metastatic colorectal cancer patients.
    Clin Cancer Res. 2016 Aug 9. pii: clincanres.1012.2016.
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  34. YAMAMOTO T, Kawada K, Itatani Y, Inamoto S, et al
    Loss of SMAD4 Promotes Lung Metastasis of Colorectal Cancer by Accumulation of CCR1+ Tumor-associated Neutrophils through CCL15-CCR1 Axis.
    Clin Cancer Res. 2016 Aug 4. pii: clincanres.0520.2016.
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  35. MUSTAFI R, Dougherty U, Mustafi D, Ayaloglu-Butun F, et al
    ADAM17 is a tumor promoter and therapeutic target in Western diet-associated colon cancer.
    Clin Cancer Res. 2016 Aug 3. pii: clincanres.3140.2016.
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  36. Correction: MEK plus PI3K/mTORC1/2 Therapeutic Efficacy Is Impacted by TP53 Mutation in Preclinical Models of Colorectal Cancer.
    Clin Cancer Res. 2016;22:3982.
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    July 2016
  37. TRINH A, Trumpi K, de Sousa E Melo F, Wang X, et al
    Practical and Robust Identification of Molecular Subtypes in Colorectal Cancer by Immunohistochemistry.
    Clin Cancer Res. 2016 Jul 26. pii: clincanres.0680.2016.
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  38. QIAN DC, Xiao X, Byun J, Suriawinata AA, et al
    PI3K/Akt/mTOR signaling and plasma membrane proteins are implicated in responsiveness to adjuvant dendritic cell vaccination for metastatic colorectal cancer.
    Clin Cancer Res. 2016 Jul 19. pii: clincanres.0623.2016.
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  39. DE ROBERTIS M, Loiacono L, Fusilli C, Poeta LM, et al
    Dysregulation of EGFR pathway in EphA2 cell subpopulation significantly associates with poor prognosis in colorectal cancer.
    Clin Cancer Res. 2016 Jul 11. pii: clincanres.0709.2016.
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  40. BENSON AB, Kiss I, Bridgewater J, Eskens FA, et al
    BATON-CRC: a phase II randomized trial comparing tivozanib plus mFOLFOX6 with bevacizumab plus mFOLFOX6 in stage IV metastatic colorectal cancer.
    Clin Cancer Res. 2016 Jul 11. pii: clincanres.3117.2016.
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    June 2016
  41. BARRAS D, Missiaglia E, Wirapati P, Sieber OM, et al
    BRAF V600E mutant colorectal cancer subtypes based on gene expression.
    Clin Cancer Res. 2016 Jun 27. pii: clincanres.0140.2016.
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  42. KUROIWA-TRZMIELINA J, Wang F, Rapkins RW, Ward RL, et al
    SNP rs16906252C>T is an expression and methylation quantitative trait locus associated with an increased risk of developing MGMT-methylated colorectal cancer.
    Clin Cancer Res. 2016 Jun 7. pii: clincanres.2765.2015.
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    May 2016
  43. LIU G, Tu D, Lewis M, Cheng D, et al
    Fc-gamma Receptor Polymorphisms, Cetuximab Therapy, and Survival in the NCIC CTG CO.17 Trial of Colorectal Cancer.
    Clin Cancer Res. 2016;22:2435-44.
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  44. MUNAKATA K, Uemura M, Tanaka S, Kawai K, et al
    Cancer stem-like properties in colorectal cancer cells with low proteasome activity.
    Clin Cancer Res. 2016 May 10. pii: clincanres.1945.2015.
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  45. WENG W, Okugawa Y, Toden S, Toiyama Y, et al
    FOXM1 and FOXQ1 are promising prognostic biomarkers and novel targets of tumor suppressive miR-342 in human colorectal cancer.
    Clin Cancer Res. 2016 May 9. pii: clincanres.0360.2016.
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  46. DUNNE PD, McArt DG, Bradley CA, O'Reilly PG, et al
    Challenging the cancer molecular stratification dogma: Intratumoral heterogeneity undermines consensus molecular subtypes and potential diagnostic value in colorectal cancer.
    Clin Cancer Res. 2016 May 5. pii: clincanres.0032.2016.
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    April 2016
  47. MEYN RE, Krishnan S, Skinner HD
    Everything Old Is New Again: Using Nelfinavir to Radiosensitize Rectal Cancer.
    Clin Cancer Res. 2016;22:1834-6.
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  48. HILL EJ, Roberts C, Franklin JM, Enescu M, et al
    Clinical Trial of Oral Nelfinavir before and during Radiation Therapy for Advanced Rectal Cancer.
    Clin Cancer Res. 2016;22:1922-31.
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  49. FERREIRO-NEIRA I, Torres NE, Liesenfeld LF, Chan CH, et al
    XPO1 Inhibition Enhances Radiation Response in Preclinical Models of Rectal Cancer.
    Clin Cancer Res. 2016;22:1663-73.
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    February 2016
  50. DUDLEY JC, Lin MT, Le DT, Eshleman JR, et al
    Microsatellite Instability as a Biomarker for PD-1 Blockade.
    Clin Cancer Res. 2016;22:813-20.
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  51. MEULENDIJKS D, Jacob W, Martinez-Garcia M, Taus A, et al
    First-in-Human Phase I Study of Lumretuzumab, a Glycoengineered Humanized Anti-HER3 Monoclonal Antibody, in Patients with Metastatic or Advanced HER3-Positive Solid Tumors.
    Clin Cancer Res. 2016;22:877-85.
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  52. PATNAIK A, Weiss GJ, Leonard JE, Rasco DW, et al
    Safety, Pharmacokinetics, and Pharmacodynamics of a Humanized Anti-Semaphorin 4D Antibody, in a First-In-Human Study of Patients with Advanced Solid Tumors.
    Clin Cancer Res. 2016;22:827-36.
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  53. MEULENDIJKS D, Lassen UN, Siu LL, Huitema AD, et al
    Exposure and Tumor Fn14 Expression as Determinants of Pharmacodynamics of the Anti-TWEAK Monoclonal Antibody RG7212 in Patients with Fn14-Positive Solid Tumors.
    Clin Cancer Res. 2016;22:858-67.
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  54. SCHELL MJ, Yang M, Missiaglia E, Delorenzi M, et al
    A Composite Gene Expression Signature Optimizes Prediction of Colorectal Cancer Metastasis and Outcome.
    Clin Cancer Res. 2016;22:734-45.
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  55. XU L, Ziegelbauer J, Wang R, Wu WW, et al
    Distinct Profiles for Mitochondrial t-RNAs and Small Nucleolar RNAs in Locally Invasive and Metastatic Colorectal Cancer.
    Clin Cancer Res. 2016;22:773-84.
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  56. ARQUES O, Chicote I, Puig I, Tenbaum SP, et al
    Tankyrase Inhibition Blocks Wnt/beta-Catenin Pathway and Reverts Resistance to PI3K and AKT Inhibitors in the Treatment of Colorectal Cancer.
    Clin Cancer Res. 2016;22:644-56.
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    January 2016
  57. ZIEMKE EK, Dosch JS, Maust JD, Shettigar A, et al
    Sensitivity of KRAS-Mutant Colorectal Cancers to Combination Therapy That Cotargets MEK and CDK4/6.
    Clin Cancer Res. 2016;22:405-14.
    >> Share

  58. TURKSMA AW, Coupe VM, Shamier MC, Lam KL, et al
    Extent and Location of Tumor-Infiltrating Lymphocytes in Microsatellite-Stable Colon Cancer Predict Outcome to Adjuvant Active Specific Immunotherapy.
    Clin Cancer Res. 2016;22:346-56.
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  59. INAMOTO S, Itatani Y, Yamamoto T, Minamiguchi S, et al
    Loss of SMAD4 Promotes Colorectal Cancer Progression by Accumulation of Myeloid-Derived Suppressor Cells through the CCL15-CCR1 Chemokine Axis.
    Clin Cancer Res. 2016;22:492-501.
    >> Share


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