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Articles published in
J Clin Invest
    April 2024
  1. JOHNSON N
    Surviving without BRCA2: MLH1 gets R-looped in to curtail genomic instability.
    J Clin Invest. 2024;134:e179325.
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    February 2024
  2. LI Z, Metzger Filho O, Viale G, dell'Orto P, et al
    HER2 heterogeneity and treatment response-associated profiles in HER2-positive breast cancer in the NCT02326974 clinical trial.
    J Clin Invest. 2024 Feb 1:e176454. doi: 10.1172/JCI176454.
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    January 2024
  3. LUO M, Bao L, Xue Y, Zhu M, et al
    ZMYND8 protects breast cancer stem cells against oxidative stress and ferroptosis through activation of NRF2.
    J Clin Invest. 2024;134:e171166.
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  4. PEYVANDI S, Bulliard M, Yilmaz A, Kauzlaric A, et al
    Tumor-educated Gr1+CD11b+ cells drive breast cancer metastasis via OSM/IL6-JAK-induced cancer cell plasticity.
    J Clin Invest. 2024 Jan 18:e166847. doi: 10.1172/JCI166847.
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    December 2023
  5. FARES J, Petrosyan E, Kanojia D, Dmello C, et al
    Metixene is an incomplete autophagy inducer in preclinical models of metastatic cancer and brain metastases.
    J Clin Invest. 2023;133:e161142.
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    November 2023
  6. LI M, Nishimura T, Takeuchi Y, Hongu T, et al
    FXYD3 functionally demarcates an ancestral breast cancer stem cell subpopulation with features of drug-tolerant persisters.
    J Clin Invest. 2023;133:e166666.
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    October 2023
  7. KINA E, Laverdure JP, Durette C, Lanoix J, et al
    Breast cancer immunopeptidomes contain numerous shared tumor antigens.
    J Clin Invest. 2023 Oct 31:e166740. doi: 10.1172/JCI166740.
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  8. IRANI S, Tan W, Li Q, Toy W, et al
    Somatic estrogen receptor alpha mutations that induce dimerization promote receptor activity and breast cancer proliferation.
    J Clin Invest. 2023 Oct 26:e163242. doi: 10.1172/JCI163242.
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  9. ZHAO N, Kabotyanski EB, Saltzman AB, Malovannaya A, et al
    Targeting EIF4A triggers an interferon response to synergize with chemotherapy and suppress triple-negative breast cancer.
    J Clin Invest. 2023 Oct 24:e172503. doi: 10.1172/JCI172503.
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  10. XIONG SY, Wen HZ, Dai LM, Lou YX, et al
    A brain-tumor neural circuit controls breast cancer progression in mice.
    J Clin Invest. 2023 Oct 17:e167725. doi: 10.1172/JCI167725.
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    September 2023
  11. CHANG HL, Schwettmann B, McArthur HL, Chan IS, et al
    Antibody-drug conjugates in breast cancer: overcoming resistance and boosting immune response.
    J Clin Invest. 2023;133:e172156.
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  12. BAO L, Kumar A, Zhu M, Peng Y, et al
    SAP30 promotes breast tumor progression by bridging the transcriptional corepressor SIN3 complex and MLL1.
    J Clin Invest. 2023;133:e168362.
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    July 2023
  13. DEVARAJAN R, Izzi V, Peltoketo H, Rask G, et al
    Targeting collagen XVIII improves the efficiency of ErbB inhibitors in breast cancer models.
    J Clin Invest. 2023 Jul 27:e159181. doi: 10.1172/JCI159181.
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  14. YANG M, Li Y, Kong L, Huang S, et al
    Inhibition of DPAGT1 suppresses HER2 shedding and trastuzumab resistance in human breast cancer.
    J Clin Invest. 2023;133:e164428.
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    June 2023
  15. LIN Q, Liu T, Wang X, Hou G, et al
    Long noncoding RNA HITT coordinates with RGS2 to inhibit PD-L1 translation in T cell immunity.
    J Clin Invest. 2023;133:e162951.
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    April 2023
  16. BERTOLINI I, Perego M, Nefedova Y, Lin C, et al
    Intercellular hif1alpha reprograms mammary progenitors and myeloid immune evasion to drive high-risk breast lesions.
    J Clin Invest. 2023;133:e164348.
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    March 2023
  17. ZHENG C, Wei Y, Zhang P, Xu L, et al
    CRISPR/Cas9 screen uncovers functional translation of cryptic lncRNA-encoded open reading frames in human cancer.
    J Clin Invest. 2023;133:e159940.
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    February 2023
  18. NANDI I, Smith HW, Sanguin-Gendreau V, Ji L, et al
    Coordinated activation of c-Src and FOXM1 drives tumor cell proliferation and breast cancer progression.
    J Clin Invest. 2023 Feb 16:e162324. doi: 10.1172/JCI162324.
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    December 2022
  19. COLLIGAN SH, Amitrano AM, Zollo RA, Peresie J, et al
    Inhibiting the biogenesis of myeloid-derived suppressor cells enhances immunotherapy efficacy against mammary tumor progression.
    J Clin Invest. 2022;132:e158661.
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  20. HORVAT NK, Lesinski GB
    Bring on the brequinar: an approach to enforce the differentiation of myeloid-derived suppressor cells.
    J Clin Invest. 2022;132:e165506.
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    October 2022
  21. ARAUJO AM, Abaurrea A, Azcoaga P, Lopez-Velazco JI, et al
    Stromal oncostatin M cytokine promotes breast cancer progression by reprogramming the tumor microenvironment.
    J Clin Invest. 2022;132.
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  22. SHARMA S, Opyrchal M, Lu X
    Harnessing tumorous flaws for immune supremacy: is miRNA-155 the weak link in breast cancer progression?
    J Clin Invest. 2022;132.
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    August 2022
  23. WANG J, Wang Q, Guan Y, Sun Y, et al
    Breast cancer cell-derived microRNA-155 suppresses tumor progression via enhancing immune cell recruitment and anti-tumor function.
    J Clin Invest. 2022 Aug 4. pii: 157248. doi: 10.1172/JCI157248.
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    June 2022
  24. LU Z, Mao W, Yang H, Santiago-O'Farrill JM, et al
    SIK2 inhibition enhances PARP inhibitor activity synergistically in ovarian and triple-negative breast cancers.
    J Clin Invest. 2022;132.
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    May 2022
  25. SZCZEPANIAK P, Siedlinski M, Hodorowicz-Zaniewska D, Nosalski R, et al
    Breast cancer chemotherapy induces vascular dysfunction and hypertension through NOX4 dependent mechanism.
    J Clin Invest. 2022 May 26. pii: 149117. doi: 10.1172/JCI149117.
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    April 2022
  26. WAARTS MR, Stonestrom AJ, Park YC, Levine RL, et al
    Targeting mutations in cancer.
    J Clin Invest. 2022;132.
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    March 2022
  27. HUANG C, Hu F, Song D, Sun X, et al
    EZH2-triggered methylation of SMAD3 promotes its activation and tumor metastasis.
    J Clin Invest. 2022;132.
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  28. ABU-LIBDEH B, Jhujh SS, Dhar S, Sommers JA, et al
    RECON syndrome is a genome instability disorder caused by mutations in the DNA helicase RECQL1.
    J Clin Invest. 2022;132.
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  29. SUN S, Brazhnik K, Lee M, Maslov AY, et al
    Single-cell analysis of somatic mutation burden in mammary epithelial cells of pathogenic BRCA1/2 mutation carriers.
    J Clin Invest. 2022;132.
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    February 2022
  30. ARAUJO AM, Abaurrea A, Azcoaga P, Lopez-Velazco JI, et al
    Stromal Oncostatin M cytokine promotes breast cancer progression by reprogramming the tumour microenvironment.
    J Clin Invest. 2022 Feb 22. pii: 148667. doi: 10.1172/JCI148667.
    >> Share

    January 2022
  31. YUE Z, Niu X, Yuan Z, Qin Q, et al
    RSPO2 and RANKL signal through LGR4 to regulate osteoclastic premetastatic niche formation and bone metastasis.
    J Clin Invest. 2022;132.
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  32. XU J, Su SM, Zhang X, Chan UI, et al
    ATP11B inhibits breast cancer metastasis in a mouse model by suppressing externalization of non-apoptotic phosphatidylserine.
    J Clin Invest. 2022 Jan 13. pii: 149473. doi: 10.1172/JCI149473.
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    December 2021
  33. RAE JM, Lippman ME
    The role of estrogen receptor signaling in suppressing the immune response to cancer.
    J Clin Invest. 2021;131.
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  34. KISHIKAWA T, Higuchi H, Wang L, Panch N, et al
    WWP1 inactivation enhances efficacy of PI3K inhibitors while suppressing their toxicities in breast cancer models.
    J Clin Invest. 2021;131.
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    November 2021
  35. EL-HOUJEIRI L, Biondini M, Paquette M, Kuasne H, et al
    Folliculin impairs breast tumor growth by repressing TFE3-dependent induction of the Warburg effect and angiogenesis.
    J Clin Invest. 2021;131.
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    March 2021
  36. MUSCARELLA AM, Aguirre S, Hao X, Waldvogel SM, et al
    Exploiting bone niches: progression of disseminated tumor cells to metastasis.
    J Clin Invest. 2021;131.
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  37. KARTHIKEYAN S, Waters IG, Dennison L, Chu D, et al
    Hierarchical tumor heterogeneity mediated by cell contact between distinct genetic subclones.
    J Clin Invest. 2021;131.
    >> Share


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