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Alzheimer's Disease
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Articles published in
Nature
    April 2024

  1. A test for Alzheimer's-disease stage predicts dementia risk.
    Nature. 2024;628:11.
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  2. WEN X, Luo Z, Zhao W, Calandrelli R, et al
    Single-cell multiplex chromatin and RNA interactions in ageing human brain.
    Nature. 2024;628:648-656.
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    March 2024
  3. HANEY MS, Palovics R, Munson CN, Long C, et al
    APOE4/4 is linked to damaging lipid droplets in Alzheimer's disease microglia.
    Nature. 2024 Mar 13. doi: 10.1038/s41586-024-07185.
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  4. MURDOCK MH, Yang CY, Sun N, Pao PC, et al
    Multisensory gamma stimulation promotes glymphatic clearance of amyloid.
    Nature. 2024;627:149-156.
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  5. LANDHUIS E
    Researchers call for a major rethink of how Alzheimer's treatments are evaluated.
    Nature. 2024;627:S18-S20.
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    February 2024
  6. LENHARO M
    Obesity drugs have another superpower: taming inflammation.
    Nature. 2024;626:246.
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    January 2024
  7. KRAMER K
    Daily briefing: New evidence supports controversial hypothesis of 'transmissible' Alzheimer's.
    Nature. 2024 Jan 30. doi: 10.1038/d41586-024-00282.
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  8. GRAHAM F
    Daily briefing: Drugs such as Ozempic could help with Alzheimer's and Parkinson's.
    Nature. 2024 Jan 29. doi: 10.1038/d41586-024-00272.
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  9. WONG C
    Signs of 'transmissible' Alzheimer's seen in people who received growth hormone.
    Nature. 2024 Jan 29. doi: 10.1038/d41586-024-00268.
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  10. LOVESTAM S, Li D, Wagstaff JL, Kotecha A, et al
    Disease-specific tau filaments assemble via polymorphic intermediates.
    Nature. 2024;625:119-125.
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  11. IRVING-PEASE EK, Refoyo-Martinez A, Barrie W, Ingason A, et al
    The selection landscape and genetic legacy of ancient Eurasians.
    Nature. 2024;625:312-320.
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    December 2023
  12. THOMPSON T
    How CRISPR gene editing could help treat Alzheimer's.
    Nature. 2023 Dec 11. doi: 10.1038/d41586-023-03931.
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  13. OH HS, Rutledge J, Nachun D, Palovics R, et al
    Organ aging signatures in the plasma proteome track health and disease.
    Nature. 2023;624:164-172.
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    November 2023
  14. KOZLOV M
    AI that reads brain scans shows promise for finding Alzheimer's genes.
    Nature. 2023 Nov 10. doi: 10.1038/d41586-023-03482.
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    October 2023
  15. REARDON S
    The brain cells linked to protection against dementia.
    Nature. 2023;622:229-230.
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    September 2023
  16. KRAMER K
    Daily briefing: Alzheimer's makes brain cells undergo 'cellular suicide'.
    Nature. 2023 Sep 19. doi: 10.1038/d41586-023-02965.
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    August 2023
  17. REARDON S
    Alzheimer's drug trials plagued by lack of racial diversity.
    Nature. 2023 Aug 2. doi: 10.1038/d41586-023-02464.
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    July 2023
  18. GRAHAM F
    Daily briefing: Abnormal protein levels could be an early hallmark of Alzheimer's disease.
    Nature. 2023 Jul 24. doi: 10.1038/d41586-023-02418.
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  19. REARDON S
    Alzheimer's drug donanemab helps most when taken at earliest disease stage, study finds.
    Nature. 2023 Jul 17. doi: 10.1038/d41586-023-02321.
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    May 2023
  20. DEPP C, Sun T, Sasmita AO, Spieth L, et al
    Myelin dysfunction drives amyloid-beta deposition in models of Alzheimer's disease.
    Nature. 2023 May 31. doi: 10.1038/s41586-023-06120.
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  21. REARDON S
    How one man's rare Alzheimer's mutation delayed the onset of disease.
    Nature. 2023 May 15. doi: 10.1038/d41586-023-01610.
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  22. REARDON S
    Alzheimer's drug donanemab: what promising trial means for treatments.
    Nature. 2023 May 4. doi: 10.1038/d41586-023-01537.
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    April 2023
  23. ABBOTT A, Thompson B
    Audio long read: Conquering Alzheimer's - a look at the therapies of the future.
    Nature. 2023 Apr 28. doi: 10.1038/d41586-023-01351.
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  24. ABBOTT A
    Conquering Alzheimer's: a look at the therapies of the future.
    Nature. 2023;616:26-28.
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    March 2023
  25. GULDNER IH, Wyss-Coray T
    Activated immune cells drive neurodegeneration in an Alzheimer's model.
    Nature. 2023 Mar 8. doi: 10.1038/d41586-023-00600.
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  26. CHEN X, Firulyova M, Manis M, Herz J, et al
    Microglia-mediated T cell infiltration drives neurodegeneration in tauopathy.
    Nature. 2023;615:668-677.
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    February 2023
  27. REIMAN EM
    Drug trial for Alzheimer's disease is a game changer.
    Nature. 2023 Feb 13. doi: 10.1038/d41586-023-00393.
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  28. MARTIN-PENA A, Tansey MG
    The Alzheimer's risk gene APOE modulates the gut-brain axis.
    Nature. 2023 Feb 6. doi: 10.1038/d41586-023-00261.
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    January 2023
  29. ELSE H
    Alzheimer's drug saga prompts journal to scrutinize whistle-blowers.
    Nature. 2023 Jan 12. doi: 10.1038/d41586-023-00050.
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  30. REARDON S
    FDA approves Alzheimer's drug lecanemab amid safety concerns.
    Nature. 2023;613:227-228.
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    November 2022
  31. PRILLAMAN M
    Heralded Alzheimer's drug works - but safety concerns loom.
    Nature. 2022 Nov 30. doi: 10.1038/d41586-022-04240.
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  32. YUAN P, Zhang M, Tong L, Morse TM, et al
    PLD3 affects axonal spheroids and network defects in Alzheimer's disease.
    Nature. 2022 Nov 30. doi: 10.1038/s41586-022-05491.
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  33. COBOS I, Palop JJ
    Swollen axons impair neuronal circuits in Alzheimer's disease.
    Nature. 2022 Nov 30. doi: 10.1038/d41586-022-03800.
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  34. GRAHAM F
    Daily briefing: How an Alzheimer's gene ravages the brain.
    Nature. 2022 Nov 17. doi: 10.1038/d41586-022-03780.
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  35. WAGNER J, Degenhardt K, Veit M, Louros N, et al
    Medin co-aggregates with vascular amyloid-beta in Alzheimer's disease.
    Nature. 2022 Nov 16. pii: 10.1038/s41586-022-05440.
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  36. DOLGIN E
    This is how an Alzheimer's gene ravages the brain.
    Nature. 2022 Nov 16. pii: 10.1038/d41586-022-03724.
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  37. PETRIC HOWE N, Thompson B
    How a key Alzheimer's gene wreaks havoc in the brain.
    Nature. 2022 Nov 16. pii: 10.1038/d41586-022-03746.
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  38. CARLSTROM K, Castelo-Branco G
    Alzheimer's risk variant APOE4 linked to myelin-assembly malfunction.
    Nature. 2022 Nov 16. pii: 10.1038/d41586-022-03371.
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  39. BLANCHARD JW, Akay LA, Davila-Velderrain J, von Maydell D, et al
    APOE4 impairs myelination via cholesterol dysregulation in oligodendrocytes.
    Nature. 2022;611:769-779.
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  40. DRIEU A, Du S, Storck SE, Rustenhoven J, et al
    Parenchymal border macrophages regulate the flow dynamics of the cerebrospinal fluid.
    Nature. 2022;611:585-593.
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    October 2022
  41. YANG Y, Shi Y, Schweighauser M, Zhang X, et al
    Structures of alpha-synuclein filaments from human brains with Lewy pathology.
    Nature. 2022;610:791-795.
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    September 2022
  42. PRILLAMAN M
    Alzheimer's drug slows mental decline in trial - but is it a breakthrough?
    Nature. 2022 Sep 29. pii: 10.1038/d41586-022-03081.
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    July 2022
  43. NAIK S, Fuchs E
    Inflammatory memory and tissue adaptation in sickness and in health.
    Nature. 2022;607:249-255.
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  44. ZHOU Y, Su Y, Li S, Kennedy BC, et al
    Molecular landscapes of human hippocampal immature neurons across lifespan.
    Nature. 2022;607:527-533.
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    June 2022
  45. KARLAWISH J
    Fix the process that led to Alzheimer's drug fiasco.
    Nature. 2022;606:9.
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    May 2022
  46. KOZLOV M
    Will the FDA change how it vets drugs following the Alzheimer's debacle?
    Nature. 2022 May 13. pii: 10.1038/d41586-022-01316.
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    April 2022
  47. MILLER MB, Huang AY, Kim J, Zhou Z, et al
    Somatic genomic changes in single Alzheimer's disease neurons.
    Nature. 2022 Apr 20. pii: 10.1038/s41586-022-04640.
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    March 2022
  48. STEWART L
    The coin toss of Alzheimer's inheritance.
    Nature. 2022 Mar 17. pii: 10.1038/d41586-022-00659.
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  49. XIONG J, Kang SS, Wang Z, Liu X, et al
    FSH blockade improves cognition in mice with Alzheimer's disease.
    Nature. 2022 Mar 2. pii: 10.1038/s41586-022-04463.
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  50. A pituitary hormone has a key role in Alzheimer's disease.
    Nature. 2022 Mar 2. pii: 10.1038/d41586-022-00530.
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  51. ABBOTT A
    Could drugs prevent Alzheimer's? These trials aim to find out.
    Nature. 2022;603:216-219.
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    February 2022
  52. YANG AC, Vest RT, Kern F, Lee DP, et al
    A human brain vascular atlas reveals diverse mediators of Alzheimer's risk.
    Nature. 2022 Feb 14. pii: 10.1038/s41586-021-04369.
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  53. Molecular map of the human blood-brain barrier reveals links to Alzheimer's disease.
    Nature. 2022 Feb 14. pii: 10.1038/d41586-022-00350.
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    December 2021
  54. DE MIGUEL Z, Khoury N, Betley MJ, Lehallier B, et al
    Exercise plasma boosts memory and dampens brain inflammation via clusterin.
    Nature. 2021;600:494-499.
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    November 2021
  55. ROBINSON A
    Defining Alzheimer's, and the climate costs of AI: Books in brief.
    Nature. 2021 Nov 19. pii: 10.1038/d41586-021-03484.
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  56. MULLARD A
    More Alzheimer's drugs head for FDA review: what scientists are watching.
    Nature. 2021 Nov 15. pii: 10.1038/d41586-021-03410.
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    October 2021
  57. STAHLBERG H, Riek R
    Structural strains of misfolded tau protein define different diseases.
    Nature. 2021;598:264-265.
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  58. BERG J, Sorensen SA, Ting JT, Miller JA, et al
    Human neocortical expansion involves glutamatergic neuron diversification.
    Nature. 2021;598:151-158.
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    July 2021
  59. BARRON JJ, Molofsky AV
    A protective signal between the brain's supporting cells in Alzheimer's disease.
    Nature. 2021 Jul 14. pii: 10.1038/d41586-021-01870.
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  60. MCALPINE CS, Park J, Griciuc A, Kim E, et al
    Astrocytic interleukin-3 programs microglia and limits Alzheimer's disease.
    Nature. 2021 Jul 14. pii: 10.1038/s41586-021-03734.
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    June 2021
  61. MULLARD A
    Controversial Alzheimer's drug approval could affect other diseases.
    Nature. 2021 Jun 29. pii: 10.1038/d41586-021-01763.
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  62. GRAHAM F
    Daily briefing: Alzheimer's drug controversially approved by FDA.
    Nature. 2021 Jun 8. pii: 10.1038/d41586-021-01553.
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  63. MULLARD A
    Landmark Alzheimer's drug approval confounds research community.
    Nature. 2021 Jun 8. pii: 10.1038/d41586-021-01546.
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    May 2021
  64. ABASCAL F, Harvey LMR, Mitchell E, Lawson ARJ, et al
    Somatic mutation landscapes at single-molecule resolution.
    Nature. 2021;593:405-410.
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  65. DA MESQUITA S, Papadopoulos Z, Dykstra T, Brase L, et al
    Meningeal lymphatics affect microglia responses and anti-Abeta immunotherapy.
    Nature. 2021;593:255-260.
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    February 2021
  66. WILLYARD C
    How gut microbes could drive brain disorders.
    Nature. 2021;590:22-25.
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    January 2021
  67. ELSE H
    The science events to watch for in 2021.
    Nature. 2021;589:14-15.
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    November 2020
  68. ABBOTT A
    Are infections seeding some cases of Alzheimer's disease?
    Nature. 2020;587:22-25.
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