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Articles published in
J Neurosci
    November 2025
  1. BHATTACHARYYA A, de la Torre-Ubieta L, Zhu Y, Head E, et al
    Development of Molecular Neuropathology in Down Syndrome across the Lifespan.
    J Neurosci. 2025;45:e1365252025.
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  2. YASSINE HN, Hugo C, O'Donovan B, Stephens IO, et al
    APOE-Targeted Therapeutics for Alzheimer's Disease.
    J Neurosci. 2025;45:e1388252025.
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    October 2025
  3. FU CH, Park J, Tosi U, Blanco FA, et al
    Restoration of sFRP3 preserves the neural stem cell pool and spatial discrimination ability in a mouse model of Alzheimer's disease.
    J Neurosci. 2025 Oct 24:e0049252025. doi: 10.1523/JNEUROSCI.0049-25.2025.
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  4. Erratum: Barron et al., "Ligand for Translocator Protein Reverses Pathology in a Mouse Model of Alzheimer's Disease".
    J Neurosci. 2025;45:e1634252025.
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    September 2025
  5. QU Y, Wu Y, Xu X, Cheng W, et al
    MiR-153 Prevents NRF2 Nuclear Translocation to Drive Hypoperfusion-Related Cognitive Deficits by Targeting KPNA5.
    J Neurosci. 2025;45:e2148242025.
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    August 2025
  6. WEISS BE, Gant JC, Lin RL, Gollihue JL, et al
    Disrupted calcium dynamics in reactive astrocytes occur with endfeet-arteriole decoupling in an amyloid mouse model of Alzheimer's disease.
    J Neurosci. 2025 Aug 15:e0349252025. doi: 10.1523/JNEUROSCI.0349-25.2025.
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    June 2025
  7. GERASIMOV E, Rakovskaya A, Pchitskaya E, Vlasova O, et al
    A positive allosteric modulator of the SERCA pump rescues hippocampal neuronal circuits dysfunction and cognitive defects in a mouse model of Alzheimer's disease.
    J Neurosci. 2025 Jun 24:e2337242025. doi: 10.1523/JNEUROSCI.2337-24.2025.
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  8. JIANG Y, Sachdeva K, Goulbourne CN, Berg MJ, et al
    Increased neuronal expression of the early endosomal adaptor APPL1 replicates Alzheimer's Disease-related endosomal and synaptic dysfunction with cholinergic neurodegeneration.
    J Neurosci. 2025 Jun 13:e2331242025. doi: 10.1523/JNEUROSCI.2331-24.2025.
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    May 2025
  9. NICODEMUS J, Liu CS, Ransom L, Tan V, et al
    Sequence diversity and encoded enzymatic differences of monocistronic L1 ORF2 mRNA variants in the aged normal and Alzheimer's disease brain.
    J Neurosci. 2025 May 14:e2298242025. doi: 10.1523/JNEUROSCI.2298-24.2025.
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    April 2025
  10. MORITO T, Hashimoto S, Takamura R, Watamura N, et al
    The Role of Neprilysin and Insulin-Degrading Enzyme in the Etiology of Sporadic Alzheimer's Disease.
    J Neurosci. 2025 Apr 29:e2152242025. doi: 10.1523/JNEUROSCI.2152-24.2025.
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  11. BATTOCCHIO E
    A New Molecular Mechanism for the Late-Onset Alzheimer's Disease Risk Gene CD2AP.
    J Neurosci. 2025;45:e0046252025.
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    March 2025

  12. Retraction: Larson et al., "The Complex PrP(c)-Fyn Couples Human Oligomeric Abeta with Pathological Tau Changes in Alzheimer's Disease".
    J Neurosci. 2025 Mar 6:e0301252025. doi: 10.1523/JNEUROSCI.0301-25.2025.
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  13. Retraction: Larson et al., "Soluble alpha-Synuclein is a Novel Modulator of Alzheimer's Disease Pathophysiology".
    J Neurosci. 2025 Mar 6:e0300252025. doi: 10.1523/JNEUROSCI.0300-25.2025.
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    February 2025
  14. JAVED E, Suarez-Mendez I, Susi G, Roman JV, et al
    A Shift Toward Supercritical Brain Dynamics Predicts Alzheimer's Disease Progression.
    J Neurosci. 2025;45:e0688242024.
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    January 2025
  15. FOLEY KE, Weekman EM, Krick KE, Johnson SN, et al
    Acute Communication Between Microglia and Nonparenchymal Immune Cells in the Anti-Abeta Antibody-Injected Cortex.
    J Neurosci. 2025;45:e1456242024.
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  16. SUN X, Pan S, Li D, Su M, et al
    Cell adhesion molecule protocadherin-gammaC5 ameliorates Abeta plaque pathogenesis by modulating astrocyte function in Alzheimer's disease.
    J Neurosci. 2025 Jan 22:e0967242025. doi: 10.1523/JNEUROSCI.0967-24.2025.
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    December 2024

  17. Erratum: Tosi et al., "The Network Structure of Cognitive Impairment: From Subjective Cognitive Decline to Alzheimer's Disease".
    J Neurosci. 2024 Dec 23:e2082242024. doi: 10.1523/JNEUROSCI.2082-24.2024.
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  18. HOUCHOIS JR, Attwood JE
    The Challenges of Modulating Neuroinflammation in Alzheimer's Disease and Multiple Sclerosis with TREM2 Agonistic Antibodies.
    J Neurosci. 2024;44:e1869242024.
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  19. DUNN J, Moore C, Kim NS, Gao T, et al
    Transcription Factor-Wide Association Studies (TF-WAS) to Identify Functional SNPs in Alzheimer's Disease.
    J Neurosci. 2024 Dec 2:e1800242024. doi: 10.1523/JNEUROSCI.1800-24.2024.
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    November 2024
  20. JANG E, Hoxha K, Mozier D, Insana A, et al
    Targeting Endogenous Tau in Seeded Tauopathy Models Inhibits Tau Spread.
    J Neurosci. 2024;44:e0877242024.
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  21. SHIMOHAMA S, Fujioka R, Mihira N, Sekiguchi M, et al
    The Icelandic Mutation (APP-A673T) Is Protective against Amyloid Pathology In Vivo.
    J Neurosci. 2024;44:e0223242024.
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    October 2024
  22. MIRFAKHAR FS, Castanheira J, Domingues R, Ramalho JS, et al
    The Alzheimer's disease risk gene CD2AP functions in dendritic spines by remodeling F-actin.
    J Neurosci. 2024 Oct 15:e1734232024. doi: 10.1523/JNEUROSCI.1734-23.2024.
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  23. CAPOCCHI JK, Figueroa-Romero C, Dunham SJB, Faraci G, et al
    Symposium: What Does the Microbiome Tell Us about Prevention and Treatment of AD/ADRD?
    J Neurosci. 2024;44:e1295242024.
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    September 2024
  24. ZHANG D, Penwell T, Chen YH, Koehler A, et al
    G-Protein Signaling in Alzheimer's Disease: Spatial Expression Validation of Semi-Supervised Deep Learning Based Computational Framework.
    J Neurosci. 2024 Sep 26:e0587242024. doi: 10.1523/JNEUROSCI.0587-24.2024.
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  25. DUGAN BJ, Dockery M
    Sex-Dependent Synaptic Alterations in a Mouse Model of Alzheimer's Disease.
    J Neurosci. 2024;44:e0961242024.
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    July 2024
  26. LIN D, Gold A, Kaye S, Atkinson JR, et al
    Arachidonic Acid Mobilization and Peroxidation Promote Microglial Dysfunction in Abeta Pathology.
    J Neurosci. 2024;44:e0202242024.
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  27. STELZER GT, Lima-Filho RAS
    Amyloid-beta as a Key Player in Cerebrovascular Dysfunction in Alzheimer's Disease.
    J Neurosci. 2024;44:e0663242024.
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    June 2024
  28. ETXEBERRIA A, Shen YA, Vito S, Silverman S, et al
    Neutral or detrimental effects of TREM2 agonist antibodies in preclinical models of Alzheimer's Disease and Multiple Sclerosis.
    J Neurosci. 2024 Jun 3:e2347232024. doi: 10.1523/JNEUROSCI.2347-23.2024.
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  29. TOSI G, Nigro S, Urso D, Spinosa V, et al
    The network structure of cognitive impairment: from Subjective Cognitive Decline to Alzheimer's Disease.
    J Neurosci. 2024 Jun 3:e1344232023. doi: 10.1523/JNEUROSCI.1344-23.2023.
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    May 2024
  30. JACOBSON KR, Song H
    Changes in the Extracellular Matrix with Aging: A Larger Role in Alzheimer's Disease.
    J Neurosci. 2024;44:e0081242024.
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  31. Erratum: Iba et al., "Synthetic Tau Fibrils Mediate Transmission of Neurofibrillary Tangles in a Transgenic Mouse Model of Alzheimer's-Like Tauopathy".
    J Neurosci. 2024 May 28:e0865242024. doi: 10.1523/JNEUROSCI.0865-24.2024.
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  32. LIU Y, Kwok W, Yoon H, Ryu JC, et al
    Imbalance in Glucose Metabolism Regulates the Transition of Microglia from Homeostasis to Disease-Associated Microglia Stage 1.
    J Neurosci. 2024;44:e1563232024.
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    April 2024
  33. ZHANG A, Wengler K, Zhu X, Horga G, et al
    Altered hierarchical gradients of intrinsic neural timescales in mild cognitive impairment and Alzheimer's disease.
    J Neurosci. 2024 Apr 24:e2024232024. doi: 10.1523/JNEUROSCI.2024-23.2024.
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  34. MURAKAMI R, Watanabe H, Hashimoto H, Kashiwagi-Hakozaki M, et al
    Inhibitory roles of Apolipoprotein E Christchurch astrocytes in curbing tau propagation using human pluripotent stem cell-derived models.
    J Neurosci. 2024 Apr 22:e1709232024. doi: 10.1523/JNEUROSCI.1709-23.2024.
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  35. AHMADI K, Pereira JB, Westen DV, Pasternak O, et al
    Fixel-based analysis reveals tau-related white matter changes in early stages of Alzheimer's disease.
    J Neurosci. 2024 Apr 2:e0538232024. doi: 10.1523/JNEUROSCI.0538-23.2024.
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    March 2024
  36. YE Q, Gast G, Wilfley EG, Huynh H, et al
    Monosynaptic rabies tracing reveals sex- and age-dependent dorsal subiculum connectivity alterations in an Alzheimer's disease mouse model.
    J Neurosci. 2024 Mar 19:e1796232024. doi: 10.1523/JNEUROSCI.1796-23.2024.
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    February 2024
  37. REN Q, Wang S, Li J, Cao K, et al
    Novel social stimulation ameliorates memory deficit in Alzheimer's disease model through activating alpha-secretase.
    J Neurosci. 2024 Feb 28:e1689232024. doi: 10.1523/JNEUROSCI.1689-23.2024.
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  38. ZHOU J, Wearn A, Huck J, Hughes C, et al
    Iron deposition and distribution across the hippocampus is associated with pattern separation and pattern completion in older adults at risk for Alzheimer's disease.
    J Neurosci. 2024 Feb 22:e1973232024. doi: 10.1523/JNEUROSCI.1973-23.2024.
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  39. MABOUDIAN SA, Willbrand EH, Jagust WJ, Weiner KS, et al
    Defining overlooked structures reveals new associations between cortex and cognition in aging and Alzheimer's disease.
    J Neurosci. 2024 Feb 21:e1714232024. doi: 10.1523/JNEUROSCI.1714-23.2024.
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  40. KIM CM, Diez I, Bueicheku E, Ahn S, et al
    Spatiotemporal Correlation between Amyloid and Tau Accumulations Underlies Cognitive Changes in Aging.
    J Neurosci. 2024;44:e0488232023.
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  41. PHILLIPS JS, Robinson JL, Cousins KAQ, Wolk DA, et al
    Polypathologic Associations with Gray Matter Atrophy in Neurodegenerative Disease.
    J Neurosci. 2024;44:e0808232023.
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    January 2024
  42. NIRAULA S, Yan SS, Subramanian J
    Amyloid Pathology Impairs Experience-Dependent Inhibitory Synaptic Plasticity.
    J Neurosci. 2024;44:e0702232023.
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  43. LOWERISON MR, Sekaran NVC, Dong Z, Chen X, et al
    Super-resolution ultrasound reveals cerebrovascular impairment in a mouse model of Alzheimer's Disease.
    J Neurosci. 2024 Jan 22:e1251232024. doi: 10.1523/JNEUROSCI.1251-23.2024.
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    November 2023
  44. LUKE R, Alymova I
    Unraveling the Mechanisms Underlying Disordered Sleep in Alzheimer's Disease.
    J Neurosci. 2023;43:7899-7901.
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  45. BARTOSCH AMW, Youth EHH, Hansen S, Wu Y, et al
    ZCCHC17 modulates neuronal RNA splicing and supports cognitive resilience in Alzheimer's disease.
    J Neurosci. 2023 Nov 22:JN-RM-2324-22. doi: 10.1523/JNEUROSCI.2324-22.2023.
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  46. IWATSUBO T, Irizarry MC, Lewcock JW, Carrillo MC, et al
    Alzheimer's targeted treatments: focus on amyloid and inflammation.
    J Neurosci. 2023 Nov 14:JN-DP-1576-23. doi: 10.1523/JNEUROSCI.1576-23.2023.
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    October 2023
  47. ECKMAN EA, Clausen DM, Sole-Domenech S, Lee CW, et al
    Nascent Abeta42 fibrillization in synaptic endosomes precedes plaque formation in a mouse model of Alzheimer's like beta-amyloidosis.
    J Neurosci. 2023 Oct 26:JN-RM-1318-23. doi: 10.1523/JNEUROSCI.1318-23.2023.
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  48. SANO T, Ochiai T, Nagayama T, Nakamura A, et al
    Genetic Reduction of Insulin Signaling Mitigates Amyloid-beta Deposition by Promoting Expression of Extracellular Matrix Proteins in the Brain.
    J Neurosci. 2023;43:7226-7241.
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  49. ALLARD S, Hussain Shuler MG
    Cholinergic Reinforcement Signaling Is Impaired by Amyloidosis Prior to Its Synaptic Loss.
    J Neurosci. 2023;43:6988-7005.
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  50. BHEMBRE N, Bonthron C, Opazo P
    Synaptic Compensatory Plasticity in Alzheimer's Disease.
    J Neurosci. 2023;43:6833-6840.
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    September 2023
  51. ZHANG Z, Chan MY, Han L, Carreno CA, et al
    Dissociable effects of Alzheimer's Disease-related cognitive dysfunction and aging on functional brain network segregation.
    J Neurosci. 2023 Sep 15:JN-RM-0579-23. doi: 10.1523/JNEUROSCI.0579-23.2023.
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  52. CHEN L, Christenson Wick Z, Vetere LM, Vaughan N, et al
    Progressive excitability changes in the medial entorhinal cortex in the 3xTg mouse model of Alzheimer's disease pathology.
    J Neurosci. 2023 Sep 15:JN-RM-1204-23. doi: 10.1523/JNEUROSCI.1204-23.2023.
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  53. YIN P, Cai Y, Cui T, Berg AJ, et al
    Glial Sphingosine-mediated Epigenetic Regulation Stabilizes Synaptic Function in Drosophila Models of Alzheimer's Disease.
    J Neurosci. 2023 Sep 5:JN-RM-0515-23. doi: 10.1523/JNEUROSCI.0515-23.2023.
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    August 2023
  54. CASSADY KE, Chen X, Adams JN, Harrison TM, et al
    Effect of Alzheimer's pathology on task-related brain network reconfiguration in aging.
    J Neurosci. 2023 Aug 18:JN-RM-0023-23. doi: 10.1523/JNEUROSCI.0023-23.2023.
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  55. ZHOU Y, Xie L, der JS, Schuster IS, et al
    Dietary fiber and microbiota metabolite receptors enhance cognition and alleviate disease in the 5xFAD mouse model of Alzheimer's disease.
    J Neurosci. 2023 Aug 17:JN-RM-0724-23. doi: 10.1523/JNEUROSCI.0724-23.2023.
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  56. ONDREJCAK T, Klyubin I, Hu NW, O'Malley TT, et al
    Tau and Amyloid beta Protein in Patient-Derived Aqueous Brain Extracts Act Concomitantly to Disrupt Long-Term Potentiation in Vivo.
    J Neurosci. 2023;43:5870-5879.
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  57. YAO AY, Halloran PJ, Ge Y, Singh N, et al
    Bace1 deletion in the adult reverses epileptiform activity and sleep-wake disturbances in AD mice.
    J Neurosci. 2023 Aug 3:JN-RM-2124-22. doi: 10.1523/JNEUROSCI.2124-22.2023.
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    July 2023
  58. LENZ M, Eichler A, Kruse P, Galanis C, et al
    The Amyloid Precursor Protein Regulates Synaptic Transmission at Medial Perforant Path Synapses.
    J Neurosci. 2023;43:5290-5304.
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    June 2023
  59. KELLY P, Sanchez-Mico MV, Hou SS, Whiteman S, et al
    Neuronally Derived Soluble Abeta Evokes Cell-Wide Astrocytic Calcium Dysregulation in Absence of Amyloid Plaques in Vivo.
    J Neurosci. 2023;43:4926-4940.
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  60. MEDINA-SAMAME A, Paller E, Bril MR, Archvadze A, et al
    Role of Neurexins in Alzheimer's Disease.
    J Neurosci. 2023;43:4194-4196.
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    May 2023
  61. LANDRY O, Francois A, Oye Mintsa Mi-Mba MF, Traversy MT, et al
    Postsynaptic protein Shank3a deficiency synergizes with Alzheimer's disease neuropathology to impair cognitive performance in the 3xTg-AD murine model.
    J Neurosci. 2023 May 30:JN-RM-1945-22. doi: 10.1523/JNEUROSCI.1945-22.2023.
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  62. BRYANT A, Li Z, Jayakumar R, Serrano-Pozo A, et al
    Endothelial Cells are Heterogeneous in Different Brain Regions and are Dramatically Altered in Alzheimer's Disease.
    J Neurosci. 2023 May 17:JN-RM-0237-23. doi: 10.1523/JNEUROSCI.0237-23.2023.
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  63. WALKER CK, Greathouse KM, Tuscher JJ, Dammer EB, et al
    Cross-Platform Synaptic Network Analysis of Human Entorhinal Cortex Identifies TWF2 as a Modulator of Dendritic Spine Length.
    J Neurosci. 2023;43:3764-3785.
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    April 2023
  64. ZHANG K, Chen L, Li Y, Paez AG, et al
    Differential Laminar Activation Dissociates Encoding and Retrieval in the Human Medial and Lateral Entorhinal Cortex.
    J Neurosci. 2023;43:2874-2884.
    >> Share

    March 2023
  65. SOMPOL P, Gollihue JL, Weiss BE, Lin RL, et al
    Targeting Astrocyte Signaling Alleviates Cerebrovascular and Synaptic Function Deficits in a Diet-Based Mouse Model of Small Cerebral Vessel Disease.
    J Neurosci. 2023;43:1797-1813.
    >> Share

  66. MA F, Akolkar H, Xu J, Liu Y, et al
    The Amyloid Precursor Protein Modulates the Position and Length of the Axon Initial Segment.
    J Neurosci. 2023;43:1830-1844.
    >> Share

    February 2023
  67. BHATNAGAR A, Krick K, Karisetty BC, Armour EM, et al
    Tip60's novel RNA-binding function modulates alternative splicing of pre-mRNA targets implicated in Alzheimer's Disease.
    J Neurosci. 2023 Feb 24:JN-RM-2331-22. doi: 10.1523/JNEUROSCI.2331-22.2023.
    >> Share


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